CN104434545A - Cosmetic expansion bolt as well as preparation method and detection method thereof - Google Patents
Cosmetic expansion bolt as well as preparation method and detection method thereof Download PDFInfo
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- CN104434545A CN104434545A CN201410620994.7A CN201410620994A CN104434545A CN 104434545 A CN104434545 A CN 104434545A CN 201410620994 A CN201410620994 A CN 201410620994A CN 104434545 A CN104434545 A CN 104434545A
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Abstract
The invention relates to a cosmetic expansion bolt as well as a preparation method and a detection method thereof. The expansion bolt comprises cosmetics, a matrix and an expandable expansion carrier, wherein a coating layer is formed by the cosmetics and the matrix and is coated on the surface of the expansion carrier, and an expansion value of the expansion carrier is more than 1.1 after the expansion carrier is subjected to saturated water absorption. According to the cosmetic expansion bolt disclosed by the invention, a structure that the cosmetics and the matrix are coated on the expansion carrier is adopted to ensure that the cosmetic expansion bolt can be applied to a vagina and can play good roles in cleaning and moisture preserving; the expansion carrier in the expansion bolt can be used for increasing the contact area between the cosmetic expansion bolt and the vagina after the expansion carrier is expanded, and more uniform coating and more complete cleaning effects can be achieved; and moreover, the cosmetics in the expansion bolt adopt special components to ensure that the expansion bolt has very good moisture retention performance, water locking performance, vaginal mucous membrane permeability and stability.
Description
Technical field
The invention belongs to cosmetic field, particularly a kind of cosmetics expansible plug and preparation method thereof and detection method.
Background technology
As everyone knows, cosmetics smear, spray or mode that other are similar, and impose on any position of human body surface, common is skin, lip etc., to reach clean, eliminates the product of the objects such as bad smell, skin protection, moisturizing, beauty treatment.At present, modal is all carry out cosmetics that are clean and moisturizing to face, but does not also occur anyly aly can be used in vagina, plays cosmetics that are clean and moisture-keeping function to vagina.
And the cosmetics of at present listing can not play the effect of well clean and moisturizing to vagina, because existing cosmetics majority adds wetting agent in cosmetics, this cosmetics moistening effect is poor, and apt to deteriorate, and being easy to produce vaginal mucosa stimulates.
In addition, existing cosmetics have the forms such as liquid, frost, solid, although the cosmetics of these forms can meet different Man's Demands, and these forms used for cosmetic inconvenient in vagina place, and complex operation.
The cosmetics majority of prior art is the effect adding wetting agent wherein thus play moisturizing, but its moistening effect is unsatisfactory, is not suitable for applying in vagina; In order to improve the moisture retention of cosmetics expansible plug, make it have long moisturizing and the effect of lock water to vaginal mucosa, cosmetics provided by the invention comprise each composition of following parts by weight:
Methyl acrylate copolymer 2.5-4
Polyvinyl alcohol-chitosan crosslinked thing 10-15
Glycerol 1-3.
The present invention, using the composition of polyvinyl alcohol-chitosan crosslinked thing as cosmetics, serves permanent moisture-keeping function and the effect of lock water, and can not produce glutinous soapy feeling; Be applicable to applying in vagina.
Further improvement, cosmetics also comprise each composition of following parts by weight:
Isopropyl cetylate 6-12
Propylene glycol diacetate 0.5-1
Microspherical carrier material 5-9.
Preferably, microspherical carrier material is ratio of weight and number is the chitin of 3:1 and the mixture of arabic gum.
The present invention by adding the microsphere of isopropyl cetylate and propylene glycol diacetate in cosmetics expansible plug, improve the osmosis of this cosmetics expansible plug, enable this cosmetics expansible plug be deep into horny layer in vaginal mucosa, play the moisture-keeping function of cosmetics expansible plug to a deeper level.In addition, adopt the mixture of chitin and arabic gum best as the effect of microspherical carrier material.
In order to improve the stability of cosmetics expansible plug, cosmetics provided by the invention also comprise the methyl hydroxybenzoate of sodium citrate that parts by weight are 0.2-1 part and 0.1-0.3 part.
In order to improve the disintegration of expansible plug, reduce substrate to the zest of vagina, substrate of the present invention also comprises and accounts for the erythritol that substrate gross weight is 5%.
The swell value of expandable carrier of the present invention after saturated water suction is greater than 1.5, and described swell value is radial swell value; Described expandable carrier includes but not limited to cotton sliver, also can comprise other sterilizable materials that can expand, as non-woven fabrics, elastic fiber etc.
Coat of the present invention is the 1/5-4/5 place, front end that Semi surrounding type is coated in described expandable carrier, according to " human engineering suppository " shape, is designed to the shape such as duckbill, spherical, avette, bullet shaped, torpedo, cylindrical, conical or clavate.
The expandable carrier rear end of cosmetics expansible plug of the present invention is connected with bracing wire.Suppository after expansion, by the rear end bracing wire of tractive expandable carrier, be adsorbed on the virus on expandable carrier, toxin, the dead bark that comes off also pull out external in the lump, each this cosmetics expansible plug on probation just equals to do to vagina once thoroughly to clean, prevent the generation of inflammation, play clean effect.
In order to reach cosmetics expansible plug of the present invention meet water can the effect of undergoes rapid expansion, after described expandable carrier water suction, the maximum water absorption of every is not less than 1.5 milliliters.Suitable water absorption, can ensure the swell value be suitable for, too low or too high water absorption, all can cause bad impact.When water absorption is too low, can not ensure that cosmetics expansible plug of the present invention is met feature that namely water expand and makes expansion insufficient; When water absorption is too high, the absorption cosmetics that expandable carrier can be too much and limit its diffusion.Therefore, water absorption is too low or too high, is not the expandable carrier desired by the present invention.
The present invention provides the preparation method of cosmetics expansible plug on the other hand, and described method comprises the steps:
1) preparation of coat:
A. substrate is placed in water-bath heating and melting, mix homogeneously, obtained fused mass;
B. the preparation of microsphere:
I, by isopropyl cetylate and propylene glycol diacetate, is dispersed in dehydrated alcohol, obtained dispersion liquid;
II by dispersion liquid magnetic stirring apparatus at 1000rmin
-1, stir at 5 DEG C, obtained suspension;
Microspherical carrier material adds in dehydrated alcohol by III, stirs, obtained oil phase;
The suspension that step II obtains adds in the obtained oil phase of step III by IV, at 1000rmin
-1, stir at 5 DEG C, spraying dry, then use petroleum ether three times, drying at room temperature, obtained particle size range is the microsphere of 15-25 μm;
C. by methyl acrylate copolymer, polyvinyl alcohol-chitosan crosslinked thing and glycerol mix homogeneously, obtained mixture;
D. the mixture that step c is obtained is mixed homogeneously with microsphere, sodium citrate and methyl hydroxybenzoate, obtained cosmetics;
E. the cosmetics that steps d obtains are added in the obtained fused mass of step a, mix homogeneously, obtained coat;
2) poured into by coat in bolt mould, insert expandable carrier, cooling and shaping, makes expansible plug.
The preparation method of cosmetics expansible plug of the present invention have employed the integrally formed technology of disposable fill; This preparation method is simple, easy to operate, and ensure that the cosmetics expansible plug of preparation has good moisture retention and lock aqueous.
The present invention additionally provides the detection method of cosmetics expansible plug on the other hand, and described detection method comprises swell value assay method, weight differential detection method etc.
Wherein said swell value assay method comprises:
A. the radial direction along described cosmetics expansible plug end face is chosen a bit or some points, measures the initial length H of described expandable carrier;
B., after the saturated water suction of described cosmetics expansible plug, expandable carrier expansion rear length h in selected location place in a step is determined at;
When c. calculating described swell value, calculate according to I formula;
Wherein, p represent axial swell value, h represent expand after length, H represent initial length; Or described swell value assay method is as follows:
A. the axis along described cosmetics expansible plug chooses a place or some positions, measures the initial diameter R of described expandable carrier;
B., after the saturated water suction of described cosmetics expansible plug, selected location place expandable carrier expanded diameter r in a step is determined at;
When c. calculating described swell value, calculate by II formula;
Wherein, P represents the swell value of radial direction, r represents expanded diameter, R represents initial diameter; Described weight differential assay method comprises:
A. get described cosmetics expansible plug, take weight M;
B. the expandable carrier scraped in the described cosmetics expansible plug of coat is got, dry, take weight m, the weight X according to coat as described in formula III calculating:
X＝M-m
(Ⅲ)。
Further, in the detection method of cosmetics expansible plug of the present invention, described detection method comprises following at least one method:
1) swell value assay method is as follows:
A. first choose a bit or some points along the radial direction of described cosmetics expansible plug end face, after measuring the initial length H of described expandable carrier, then different angles of rolling measure several times, and average Hi;
B., after described cosmetics expansible plug carries out melting the detection of change time limit, expandable carrier expansion rear length h in selected location place in a step is determined at; Different angles of rolling again measure several times, ask average length hi after expanding;
When c. calculating described swell value, calculate according to I formula;
Wherein, pi represent axial swell value, hi represent expand after average length, Hi represent average initial length;
Or described swell value assay method is as follows:
A. first choose a place or some positions an angle along the axis of described cosmetics expansible plug, after measuring the initial diameter R of described expandable carrier, then different angles of rolling measure several times, and average Ri;
B., after described cosmetics expansible plug carries out melting the detection of change time limit, selected location place expandable carrier expanded diameter r in a step is determined at; Different angles of rolling again measure several times, ask average diameter ri after expanding;
When c. calculating described swell value, calculate by II formula;
Wherein, Pi represents the swell value of radial direction, ri represents the rear average diameter that expands, Ri represents average initial diameter.
The wherein said change time limit assay method that melts comprises: get described cosmetics expansible plug 3, after room temperature places 1 hour, be placed on respectively on lower floor's plectane of 3 metal rack, load in respective sleeve pipe, and fixing with hook.Unless otherwise specified, be dipped vertically into respectively by said apparatus in the container filling 37.0 ± 0.5 DEG C of water being no less than 4L, its upper end position at 90mm place, underwater, should fill a rot, overturn this device in the solution once every 10 minutes in container.Above numerical range should not be construed as limitation of the present invention, and the technical scheme not in above-mentioned numerical range is also in protection scope of the present invention.
2) weight differential assay method:
A. get described cosmetics expansible plug, take weight M;
B. scrape coat, expandable carrier is placed in 20-90 DEG C of organic solvent, take out, in 50-150 DEG C of dry 1-10h, take weight m, according to the weight X of coat as described in III formula calculating
X＝M-m (Ⅲ)
Wherein, described organic solvent is selected from one or more in ethanol, methanol or isopropyl alcohol.
Further, in the detection method of cosmetics expansible plug of the present invention, described expandable carrier is cotton sliver, and described detection method comprises following at least one method:
1) swell value assay method:
Get described cosmetics expansible plug 3, survey its afterbody cotton sliver diameter with slide gauge, roll 90 ° and survey again once, survey twice for every, obtain every 2 meansigma methods Ri measured; Above-mentioned 3 bolts are used for melt and become after the time limit measures and terminate, take out residue cotton sliver immediately, treat that water is disconnected to drip, all gently be placed on glass plate, the two ends of each cotton sliver and middle three positions are measured with slide gauge, roll after 90 ° and measure three positions again, each cotton sliver obtains six data altogether, obtains 6 meansigma methods r of mensuration
i, calculate the swell value P of every
i, the swell value of three bolts all should be greater than 1.5.
2) weight differential assay method:
Get described cosmetics expansible plug 10, accurately weighed weight respectively, gently scrape coat, cotton sliver must not be lost, cotton sliver is placed in the 200-400ml ethanol of 50-80 DEG C, preferably, cotton sliver is placed in the 300ml ethanol of 60-70 DEG C, and clean 5 minutes at 80khz frequency ultrasound, the stromatolysis of cotton sliver surface residual is removed, take out cotton sliver firmly to extract, 3 times are inhaled again with filter paper, in 105 DEG C of dryings 2 hours, take out, after room temperature places 1 hour, accurately weighed cotton sliver weight respectively, obtain every coat weight and average coat weight, every coat weight and average coat weight ratio are comparatively, what exceed average coat weight ± 10% must not more than 2, and 1 overrun 1 times must not be had.
The assay method of the swell value of cosmetics expansible plug provided by the present invention adopts multi-angle repetitive measurement method, improves the accuracy of measurement, adds the operability of mensuration, and method is easier to judge.
Cosmetics expansible plug provided by the present invention have employed the structure on expandable carrier by cosmetics and substrate application, makes this cosmetics expansible plug can be applicable to vagina, and plays the effect of well clean and moisturizing; Expandable carrier in expansible plug can improve the contact area of cosmetics expansible plug and vagina after expanding, and coating is more even, and cleaning effect is more thorough; And the cosmetics in expansible plug have employed special composition, make it have good moisture retention, lock aqueous, vaginal mucosa osmosis and stability.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of cosmetics of new model, i.e. cosmetics expansible plug, this cosmetics expansible plug can be used for vagina, vaginal mucosa is had to the effect of good moisturizing and lock water, and not glutinous soapy feeling, good cleaning action is played to vagina simultaneously.
The concrete technical scheme of the present invention is as follows:
The invention provides a kind of cosmetics expansible plug, this expansible plug comprises cosmetics, substrate and expandable expandable carrier; Cosmetics and substrate form coat, and are coated in expandable carrier surface, and the swell value of expandable carrier after saturated water suction is greater than 1.1, and the parts by weight of each composition of expansible plug are:
Cosmetics 80-200
Substrate 80-200
Expandable carrier 50-400
Wherein, substrate is selected from fat-soluble substrate and/or water-soluble base;
Fat-soluble substrate be selected from mixed fatty glycerides, propylene glycol stearate, fixed oil, semi-synthetic fatty acid glyceride, semi-synthetic cocos nucifera oil ester, Witepsol, semi-synthetic Petiolus Trachycarpi grease, semi-synthetic Fructus Litseae ester, oleum sapii, Oleum Linderae, Fructus Foeniculi fat, Ke Kemu fat, cocoa butter or lanoline one or more;
Water-soluble base be selected from PEG400, polyethylene glycol 1500, Macrogol 4000, polyethylene glycol 6000, glycerin gelatine, polysorbate60, polysorbate65, polyoxyethylene monostearate or poloxamer one or more.
Cosmetics expansible plug provided by the invention is specifically applied to vagina, plays clean and moisture-keeping function to vagina; Which employs " the intravaginal sticking type technology " of original creation, this technology by adding expandable carrier to realize in suppository.Ordinary suppository is due to the relation of gravity, no matter user is standing, under sitting posture or formula position of lying, always there is vagina or lessly can not to touch coat, after described expandable carrier expands, coat can contact with vaginal walls in 360 °, plays and acts on fully, enlarged areas 6 times on probation, coat directly attaches to vaginal mucosa, makes originally to contact plicated layer and also can effectively be attached.In addition, the introducing of expandable carrier applies " lateral leakage protection key " design concept, because the expansion of expandable carrier tail end, can be close to vaginal wall, and then prevent the outflow of coat, reduces the pollution of medicated clothing and keeps the valid density of coat.And by " inner core coefficient of expansion control technology ", the swell value of expandable carrier after saturated water suction can be made to be greater than 1..
In addition, in cosmetics expansible plug provided by the invention, the composition that some play sterilization, antiinflammatory action can be added, make this cosmetics expansible plug play the effects such as antiinflammatory further.
Accompanying drawing explanation
Fig. 1 use test sample after vaginal mucosa transepidermal water content results;
The schematic diagram of Fig. 2 and Fig. 3 swell value assay method.
Detailed description of the invention
Embodiment 1
Preparation method:
1) preparation of coat:
A. semi-synthetic fatty acid glyceride is placed in water-bath heating and melting, mix homogeneously, obtained fused mass;
B. by methyl acrylate copolymer, polyvinyl alcohol-chitosan crosslinked thing and glycerol mix homogeneously, obtained cosmetics;
C. the cosmetics that step c obtains are added in the obtained fused mass of step a, mix homogeneously, obtained coat;
2) poured into by coat in bolt mould, insert cotton sliver, cooling and shaping, makes 100 pieces of bullet shaped expansible plugs, every piece of heavily about 2.3g.
Embodiment 2
Preparation method: make 100 pieces of spherical expansible plugs according to the method for embodiment 1, every piece of heavily about 5.0g.
Embodiment 3
Preparation method:
1) preparation of coat:
A. polyoxyethylene monostearate is placed in water-bath heating and melting, mix homogeneously, obtained fused mass;
B. the preparation of microsphere:
I, by isopropyl cetylate and propylene glycol diacetate, is dispersed in dehydrated alcohol, obtained dispersion liquid;
II by dispersion liquid magnetic stirring apparatus at 1000rmin
-1, stir at 5 DEG C, obtained suspension;
Microspherical carrier material adds in dehydrated alcohol by III, stirs, obtained oil phase;
The suspension that step II obtains adds in the obtained oil phase of step III by IV, at 1000rmin
-1, stir at 5 DEG C, spraying dry, then use petroleum ether three times, drying at room temperature, obtained particle size range is the microsphere of 15-25 μm;
C. by methyl acrylate copolymer, polyvinyl alcohol-chitosan crosslinked thing and glycerol mix homogeneously, obtained mixture;
D. the mixture that step c is obtained is mixed homogeneously with microsphere, obtained cosmetics;
E. the cosmetics that steps d obtains are added in the obtained fused mass of step a, mix homogeneously, obtained coat;
2) poured into by coat in bolt mould, insert cotton sliver, cooling and shaping, makes 100 pieces of clavate expansible plugs, every piece of heavily about 4.2g.
Embodiment 4
Preparation method: make 100 pieces of avette expansible plugs according to the method for embodiment 3, every piece of heavily about 4.8g.
Embodiment 5
Preparation method:
1) preparation of coat:
A. poloxamer and polysorbate60 are placed in water-bath heating and melting, mix homogeneously, obtained fused mass;
B. the preparation of microsphere:
I, by isopropyl cetylate and propylene glycol diacetate, is dispersed in dehydrated alcohol, obtained dispersion liquid;
II by dispersion liquid magnetic stirring apparatus at 1000rmin
-1, stir at 5 DEG C, obtained suspension;
Microspherical carrier material adds in dehydrated alcohol by III, stirs, obtained oil phase;
The suspension that step II obtains adds in the obtained oil phase of step III by IV, at 1000rmin
-1, stir at 5 DEG C, spraying dry, then use petroleum ether three times, drying at room temperature, obtained particle size range is the microsphere of 15-25 μm;
C. by methyl acrylate copolymer, polyvinyl alcohol-chitosan crosslinked thing and glycerol mix homogeneously, obtained mixture;
D. the mixture that step c is obtained is mixed homogeneously with microsphere, sodium citrate and methyl hydroxybenzoate, obtained cosmetics;
E. the cosmetics that steps d obtains are added in the obtained fused mass of step a, mix homogeneously, obtained coat;
2) poured into by coat in bolt mould, insert expandable carrier, cooling and shaping, makes 100 pieces of cylindrical expansible plugs, every piece of heavily about 6.3g.
Embodiment 6
Preparation method: make 100 pieces of torpedo expansible plugs according to the method for embodiment 5, every piece of heavily about 4.8g.
Embodiment 7
Preparation method: make 100 pieces of duckbill expansible plugs according to embodiment 5 method, every piece of heavily about 3.2g.
Embodiment 8
Preparation method: make 100 pieces of bullet shaped expansible plugs according to embodiment 5 method, every piece of heavily about 4.8g.
Comparative examples 1
Preparation method: prepare according to the method for embodiment 1.
Comparative examples 2
Preparation method: preparation method:
1) preparation of coat:
A. polyoxyethylene monostearate is placed in water-bath heating and melting, mix homogeneously, obtained fused mass;
B. by methyl acrylate copolymer, polyvinyl alcohol-chitosan crosslinked thing and glycerol mix homogeneously, obtained mixture;
C. the mixture that step b is obtained is mixed homogeneously with isopropyl cetylate and propylene glycol diacetate, obtained cosmetics;
D. the cosmetics that step c obtains are added in the obtained fused mass of step a, mix homogeneously, obtained coat;
2) poured into by coat in bolt mould, insert cotton sliver, cooling and shaping, makes 100 pieces of clavate expansible plugs, every piece of heavily about 4.2g.
Comparative examples 3
Preparation method: prepare according to the method for embodiment 5.
Test example 1 moisture retention is tested
1.1 test apparatus
Corneometer CM 825 (CK Electronic GmbH, Germany) moisture tester, computer, thermometer and drimeter;
1.2 test samples
Embodiment 1, embodiment 3, comparative examples 1 and comparative examples 2 cosmetics expansible plug, and the expansible plug that ordinary cosmetics is made;
1.3 test method
1. tested crowd: 25 people, age 20-40 year, sex female;
2. testing experiment
Test environment temperature is 25 DEG C, and relative humidity (RH) is 65%, and tested crowd is divided into 5 groups at random, often organizes 5 people, and be numbered test 1 group, test 2 groups and contrast 1 group, contrast 2 groups and contrast 3 groups; Test the cosmetics expansible plug that 1 group and test 2 groups use the embodiment of the present invention 1 and embodiment 3 respectively, contrast 1 group, contrast 2 groups and contrast 3 groups of expansible plugs using the cosmetics expansible plug of comparative examples 1, comparative examples 2 and ordinary cosmetics to make respectively; Before use, measure by intravaginal horny layer moisture with Corneometer CM 825 tester; Get 1 piece of above-mentioned test sample, insert intravaginal, use Corneometer CM 825 tester to measure respectively when 0.5h, 1h, 2h, 3h, 6h, 12h, test out vaginal mucosa keratodermatitis moisture content value, unit is a.u.; Test result is shown in Fig. 1.
As can be seen from Figure 1, add polyvinyl alcohol-chitosan crosslinked thing in cosmetics expansible plug and can significantly improve moisture in vaginal mucosa horny layer, have good moisture retention, when polyvinyl alcohol and chitosan are not exist in expansible plug with the form of cross-linking agent, its moisture retention significantly declines; And after lacking one of them composition, moisture retention is also along with decline; The microsphere simultaneously added can improve the moisture retention of expansible plug further, more in depth can penetrate into the horny layer of vaginal mucosa.
Test example 2 stability test
1. accelerated test
Cosmetics expansible plug described in Example 1,3,5 and the cosmetics expansible plug described in comparative examples 3, all at constant temperature 30 DEG C ± 2 DEG C, relative humidity is place 6 months under the constant humidity condition of 65% ± 5%, sample respectively once 1 month, 2 months, 3 months, 6 the end of month at duration of test, detect the character of expansible plug, found that, the stability of the expansible plug of embodiment 5 is best, and speckle appears in the expansible plug surface batch of embodiment 1 and embodiment 3 and comparative example 3, and there is slight crack in demi-inflation bolt.
2. long term test
Cosmetics expansible plug described in Example 1,3,5 and the cosmetics expansible plug described in comparative examples 3, all temperature 25 DEG C ± 2 DEG C, humidity is place 24 months under the condition of 60% ± 10%, sample respectively once 0 month, 3 months, 6 months, 9 months, 12 months, 18 months, 24 the end of month at duration of test, detect the character of expansible plug, found that, the stability of the expansible plug of embodiment 5 is best, and speckle appears in the expansible plug surface batch of embodiment 1 and embodiment 3 and comparative example 3, and there is slight crack in demi-inflation bolt.
By accelerated test and long term test known, the mixture of sodium citrate and methyl hydroxybenzoate can significantly improve the stability of cosmetics expansible plug, lacks wherein a kind of composition, stability decline.
Test example 3 swell value measures
Method one
Get described cosmetics expansible plug 3, survey its afterbody cotton sliver diameter with slide gauge, roll about 90 ° and survey once again, survey twice for every, obtain every 2 meansigma methods Ri measured; Above-mentioned 3 bolts are used for melt and become after the time limit measures and terminate, take out residue cotton sliver immediately, treat that water is disconnected to drip, all gently be placed on glass plate, the two ends of each cotton sliver and middle three positions are measured with slide gauge, roll after about 90 ° and measure three positions again, each cotton sliver obtains six data altogether, obtains 6 meansigma methods r of mensuration
i, calculate the swell value P of every
i, the swell value of three bolts is all greater than 1.5.
Swell value such as the table 1 measuring cosmetics expansible plug described in embodiment 1-8 according to above-mentioned swell value assay method shows;
The swell value of table 1 embodiment 1-8 cosmetics expansible plug
| Embodiment | Average diameter (mm) before expanding | Average diameter (mm) after expanding | Swell value (doubly) | Result |
| Embodiment 1 | 11.84 | 20.74 | 1.75 | Qualified |
| Embodiment 2 | 12.13 | 22.77 | 1.88 | Qualified |
| Embodiment 3 | 12.08 | 21.58 | 1.79 | Qualified |
| Embodiment 4 | 12.21 | 23.09 | 1.89 | Qualified |
| Embodiment 5 | 11.78 | 21.32 | 1.81 | Qualified |
| Embodiment 6 | 11.96 | 20.95 | 1.75 | Qualified |
| Embodiment 7 | 12.26 | 23.31 | 1.90 | Qualified |
| Embodiment 8 | 12.11 | 22.45 | 1.85 | Qualified |
Method two
As shown in Figures 2 and 3:
1) swell value assay method:
A. first C 1, C2, C3 tri-points are chosen along the radial direction of described cosmetics expansible plug end face, measure initial length H1, H2, H3 of described expandable carrier with slide gauge after, roll again 90 ° and measure, choose after C1, C4, C5 tri-some slide gaugies measure initial length H4, H5, H6 of described expandable carrier along the radial direction of described cosmetics expansible plug end face, ask the meansigma methods Hi of H1, H2, H3, H4, H5 and H6;
B., after described cosmetics expansible plug carries out melting the detection of change time limit, C1, C2, C3 selected in a step tri-rear length h1 of position expandable carrier expansion, h2, h3 is determined at slide gauge; Roll 90 ° again, be determined at C1, C4, C5 selected in a step tri-rear length h4 of position expandable carrier expansion, h5, h6 with slide gauge, ask the average length of h1, h2, h3, h4, h5 and h6, be average length hi after expanding;
When c. calculating described swell value, calculate according to I formula;
Wherein, pi represent axial swell value, hi represent expand after average length, Hi represent average initial length;
Or, swell value assay method:
D. first A1, A2 and A3 tri-points are chosen an angle along the axis of described cosmetics expansible plug, measure initial diameter R1, R2 and R3 of described expandable carrier with slide gauge after, roll 90 ° again, axis along described cosmetics expansible plug chooses B1, B2 and B3 tri-points, measure initial diameter R4, R5 and R6 of described expandable carrier with slide gauge after, ask the meansigma methods Ri of R1, R2, R3, R4, R5 and R6 six initial diameters;
E., after described cosmetics expansible plug carries out melting the detection of change time limit, be determined at selected A1, A2 and A3 position expandable carrier expanded diameter in d step and be respectively r1, r2 and r3; B1, B2 and B3 position expandable carrier expanded diameter measured selected by d step that rolls again 90 ° is respectively r4, r5 and r6, asks the meansigma methods of r1, r2, r3, r4, r5 and r6, average diameter ri after must expanding;
When f. calculating described swell value, calculate by II formula;
Wherein, Pi represents the swell value of radial direction, ri represents the rear average diameter that expands, Ri represents average initial diameter.
Test example 4 weight differential determination test
Get described cosmetics expansible plug 10, accurately weighed weight respectively, gently scrape coat, cotton sliver must not be lost, cotton sliver is placed in the 300ml ethanol of 60-70 DEG C, and clean 5 minutes at 80kHz frequency ultrasound, the stromatolysis of cotton sliver surface residual is removed, take out cotton sliver firmly to extract, 3 times are inhaled again with filter paper, in 105 DEG C of dryings 2 hours, take out, after room temperature places 1 hour, accurately weighed cotton sliver weight respectively, obtain every coat weight and average coat weight, every coat weight and average coat weight ratio are comparatively, what exceed average coat weight ± 10% must not more than 2, and 1 overrun 1 times must not be had.
Repeat aforesaid operations, detect the cosmetics expansible plug described in embodiment 1-8, the equal conformance with standard of its weight differential.
Test example 5 cosmetics expansible plug is to the irritation test of rabbit vagina mucosa
Get rabbit 12, be divided into 3 groups at random, often organize 4, be divided into tested group 1, tested group 2 and matched group; Described tested group 1 and tested group 2 cosmetics expansible plug giving embodiment 1 and embodiment 7 respectively, every day 1 time, successive administration 7 days, matched group gives the suppository that common cosmetics are made, every day 1 time, successive administration 7 days; The daily general signs of fore-and-aft observing rabbit, comprise appetite, hair color, with or without abnormal secretion thing etc.; During administration, each group is showed no obvious abnormalities phenomenon; Last administration 24h takes out vagina tissue, for tested group 1 and tested group 2, and perusal smooth mucosal, without phenomenons such as hyperemia, edema, hemorrhage, ulcer and erosions, pathological examination mucosa structural integrity, without ulcer, inflammation and erosion formation; For matched group, perusal mucosa is more coarse, has hyperemia, edema, phenomenon, pathological examination mucosa structural integrity, but has ulcer and rotten to the corn formation; Show that cosmetics expansible plug of the present invention is to mucosa nonirritant.
Claims (11)
1. a cosmetics expansible plug, is characterized in that, described expansible plug comprises cosmetics, substrate and expandable expandable carrier; Described cosmetics and substrate form coat, and are coated in expandable carrier surface, and the swell value of described expandable carrier after saturated water suction is greater than 1.1, and the parts by weight of each composition of described expansible plug are:
Cosmetics 80-200
Substrate 80-200
Expandable carrier 50-400
Described substrate is selected from fat-soluble substrate and/or water-soluble base;
Described fat-soluble substrate be selected from mixed fatty glycerides, propylene glycol stearate, semi-synthetic fatty acid glyceride, semi-synthetic cocos nucifera oil ester, semi-synthetic Petiolus Trachycarpi grease, semi-synthetic Fructus Litseae ester, oleum sapii, Oleum Linderae, Fructus Foeniculi fat, Ke Kemu fat, cocoa butter or lanoline one or more;
Described water-soluble base be selected from PEG400, polyethylene glycol 1500, Macrogol 4000, polyethylene glycol 6000, glycerin gelatine, polysorbate60, polysorbate65, polyoxyethylene monostearate or poloxamer one or more.
2. cosmetics expansible plug as claimed in claim 1, it is characterized in that, described cosmetics comprise each composition of following parts by weight:
Methyl acrylate copolymer 2.5-4
Polyvinyl alcohol-chitosan crosslinked thing 10-15
Glycerol 1-3.
3. cosmetics expansible plug as claimed in claim 2, it is characterized in that, described cosmetics also comprise each composition of following parts by weight:
Isopropyl cetylate 6-12
Propylene glycol diacetate 0.5-1
Microspherical carrier material 5-9
Described isopropyl cetylate and propylene glycol diacetate and microspherical carrier material form microsphere.
4. cosmetics expansible plug as claimed in claim 3, it is characterized in that, described microspherical carrier material is ratio of weight and number is the chitin of 3:1 and the mixture of arabic gum.
5. cosmetics expansible plug as claimed in claim 3, is characterized in that, described cosmetics also comprise the methyl hydroxybenzoate of sodium citrate that parts by weight are 0.2-1 part and 0.1-0.3 part.
6. the cosmetics expansible plug as described in as arbitrary in claim 1-5, is characterized in that, described substrate also comprises and accounts for the erythritol that substrate gross weight is 5%.
7. the cosmetics expansible plug as described in as arbitrary in claim 1-5, it is characterized in that, the swell value of described expandable carrier after saturated water suction is greater than 1.5, and described swell value is radial swell value; Described expandable carrier is cotton sliver; Described coat is the 1/5-4/5 place, front end that Semi surrounding type is coated in described expandable carrier, and the rear end of described expandable carrier is connected with bracing wire; After described expandable carrier water suction, the maximum water absorption of every is not less than 1.5 milliliters.
8. the preparation method of cosmetics expansible plug as claimed in claim 5, it is characterized in that, described method comprises the steps:
1) preparation of coat:
A. substrate is placed in water-bath heating and melting, mix homogeneously, obtained fused mass;
B. the preparation of microsphere:
I, by isopropyl cetylate and propylene glycol diacetate, is dispersed in dehydrated alcohol, obtained dispersion liquid;
II by dispersion liquid magnetic stirring apparatus at 1000rmin
-1, stir at 5 DEG C, obtained suspension;
Microspherical carrier material adds in dehydrated alcohol by III, stirs, obtained oil phase;
The suspension that step II obtains adds in the obtained oil phase of step III by IV, at 1000rmin
-1, stir at 5 DEG C, spraying dry, then use petroleum ether three times, drying at room temperature, obtained particle size range is the microsphere of 15-25 μm;
C. by methyl acrylate copolymer, polyvinyl alcohol-chitosan crosslinked thing and glycerol mix homogeneously, obtained mixture;
D. the mixture that step c is obtained is mixed homogeneously with microsphere, sodium citrate and methyl hydroxybenzoate, obtained cosmetics;
E. the cosmetics that steps d obtains are added in the obtained fused mass of step a, mix homogeneously, obtained coat;
2) poured into by coat in bolt mould, insert expandable carrier, cooling and shaping, makes expansible plug.
9. the detection method of the cosmetics expansible plug as described in as arbitrary in claim 1-5, it is characterized in that, described detection method comprises following at least one method:
1) swell value assay method is as follows:
A. the radial direction along described cosmetics expansible plug end face is chosen a bit or some points, measures the initial length H of described expandable carrier;
B., after the saturated water suction of described cosmetics expansible plug, expandable carrier expansion rear length h in selected location place in a step is determined at;
When c. calculating described swell value, calculate according to I formula;
(I)
Wherein, p represent axial swell value, h represent expand after length, H represent initial length;
Or swell value assay method is as follows:
A. the axis along described cosmetics expansible plug chooses a place or some positions, measures the initial diameter R of described expandable carrier;
B., after the saturated water suction of described cosmetics expansible plug, selected location place expandable carrier expanded diameter r in a step is determined at;
When c. calculating described swell value, calculate by II formula;
(II)
Wherein, P represents the swell value of radial direction, r represents expanded diameter, R represents initial diameter;
2) weight differential assay method:
A. get described cosmetics expansible plug, take weight M;
B. the expandable carrier scraped in the described cosmetics expansible plug of coat is got, dry, take weight m, the weight X according to coat as described in formula III calculating:
X＝M-m
(Ⅲ)。
10. the detection method of cosmetics expansible plug as claimed in claim 9, it is characterized in that, described detection method comprises following at least one method:
1) swell value assay method is as follows:
A. first choose a bit or some points along the radial direction of described cosmetics expansible plug end face, after measuring the initial length H of described expandable carrier, then different angles of rolling measure several times, and average Hi;
B., after described cosmetics expansible plug carries out melting the detection of change time limit, expandable carrier expansion rear length h in selected location place in a step is determined at; Different angles of rolling again measure several times, ask average length hi after expanding;
When c. calculating described swell value, calculate according to I formula;
(I)
Wherein, pi represent axial swell value, hi represent expand after average length, Hi represent average initial length;
Or swell value assay method is as follows:
A. first choose a place or some positions an angle along the axis of described cosmetics expansible plug, after measuring the initial diameter R of described expandable carrier, then different angles of rolling measure several times, and average Ri;
B., after described cosmetics expansible plug carries out melting the detection of change time limit, selected location place expandable carrier expanded diameter r in a step is determined at; Different angles of rolling again measure several times, ask average diameter ri after expanding;
When c. calculating described swell value, calculate by II formula;
(II)
Wherein, Pi represents the swell value of radial direction, ri represents the rear average diameter that expands, Ri represents flat
Equal initial diameter;
2) weight differential assay method:
A. get described cosmetics expansible plug, take weight M;
B. scrape coat, expandable carrier is placed in 20-90 DEG C of organic solvent, take out, in 50-150 DEG C of dry 1-10h, take weight m, according to the weight X of coat as described in III formula calculating
X＝M-m(Ⅲ)
Wherein, described organic solvent comprises one or more in ethanol, methanol or isopropyl alcohol.
The detection method of 11. cosmetics expansible plugs as claimed in claim 10, it is characterized in that, described expandable carrier is cotton sliver, and described detection method comprises following at least one method:
1) swell value assay method:
Get described cosmetics expansible plug 3, survey its afterbody cotton sliver diameter with slide gauge, roll 90 ° and survey again once, survey twice for every, obtain every 2 meansigma methods Ri measured; Above-mentioned 3 bolts are used for melt and become after the time limit measures and terminate, take out residue cotton sliver immediately, treat that water is disconnected to drip, all gently be placed on glass plate, the two ends of each cotton sliver and middle three positions are measured with slide gauge, roll after 90 ° and measure three positions again, each cotton sliver obtains six data altogether, obtains 6 meansigma methods r of mensuration
i, calculate the swell value P of every
i, the swell value of three bolts all should be greater than 1.5;
2) weight differential assay method:
Get described cosmetics expansible plug 10, accurately weighed weight respectively, gently scrape coat, cotton sliver must not be lost, cotton sliver is placed in the 200-400ml ethanol of 50-80 DEG C, and clean 5 minutes at 80kHz frequency ultrasound, the stromatolysis of cotton sliver surface residual is removed, take out cotton sliver firmly to extract, 3 times are inhaled again with filter paper, in 105 DEG C of dryings 2 hours, take out, after room temperature places 1 hour, accurately weighed cotton sliver weight respectively, obtain every coat weight and average coat weight, every coat weight and average coat weight ratio are comparatively, what exceed average coat weight ± 10% must not more than 2, and 1 overrun 1 times must not be had.
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Effective date of registration: 20211118 Address after: 150040 office building 7, Bohai Third Road, haping road concentration area, Harbin Economic Development Zone, Harbin, Heilongjiang Province Patentee after: Harbin Tianmei Pharmaceutical Co.,Ltd. Address before: 150069, No. three, No. 7, Bohai, Harbin, Heilongjiang, China Patentee before: HARBIN OT PHARMACEUTICALS Co.,Ltd. Patentee before: Qiu Mingshi |