CN104434138B

CN104434138B - Blood collection tube

Info

Publication number: CN104434138B
Application number: CN201410054665.0A
Authority: CN
Inventors: 刘祥华; 彭勋德
Original assignee: Hunan China Sun Pharmaceutical Machinery Co Ltd
Current assignee: Hunan China Sun Pharmaceutical Machinery Co Ltd
Priority date: 2014-02-18
Filing date: 2014-02-18
Publication date: 2017-04-12
Anticipated expiration: 2034-02-18
Also published as: CN104434138A

Abstract

The blood collection tube is composed of a sealing cover and a test tube. The sealing cover is composed of a tube cap and a rubber plug. The tube cap and the rubber plug are formed through the double-shot molding technology. Firstly, the tube cap is integrally formed through injection molding, and then the tube cap is filled with the rubber plug through injection molding. The tube cap (1) is composed of a lower chamber (11) matched with the test tube, an upper chamber (14) containing the crown of the rubber plug, a step (12) and a tubular opening (13) which extends downwards from the top end of the upper chamber. The opening (13) and the top of the rubber plug jointly form a groove, consumption of rubber is reduced, and the cost is reduced remarkably.

Description

A kind of heparin tube

Technical field

Present invention relates particularly to a kind of heparin tube of new construction, relates more specifically to reduce consumption and the raising of plug rubber The heparin tube of performance.

Background technology

Existing heparin tube, is mainly made up of closure and test tube, and closure is made up of lid and plug, its lid top Upper chamber is provided with, the plug for accommodating plug is preced with, and lid lower chambers coordinate with test tube, and step is provided between upper and lower chamber, are used for The plug of sealing test tube is transferred to from test tube simultaneously when lid is taken out from test tube.

Plug is made up of the plug neck, plug hat for sealing in test tube, in order to blood flows out pollution when preventing blood taking needle from transfering to plug, Groove is provided with the top of plug, for accommodating the blood of blood taking needle outflow.

Lid just seals in test tube with plug, in order to be beneficial to blood sampling, general vacuum state in test tube.

The plug for sealing test tube simultaneously makes respectively with lid, and first lid can be buckled on test tube during assembling, then by plug Test tube is sealed in press-in test tube.

Due to be provided with the groove for accommodating the blood that blood taking needle drips on plug, therefore the plug crown moieties of chamber plug must have Certain height（Typically in more than 5mm, such as 5-10mm, such as 6,7,8,9mm）, while to ensure that plug is conveniently filled in test tube And transfer to from test tube, plug hat is typically designed bigger than filling in neck（The big 2mm of general diameter）, because the material cost of plug (rubber) is 5 times or so of the cost of lid (plastics), therefore plug is relatively costly, and heparin tube is not high due to technology content, price factor into For product prime competing factor, therefore reduces cost of employing new technology seems relatively important.

Simultaneously using front, the groove of the plug of heparin tube is constantly exposed in air, because blood-collecting environment is not clean Room, therefore be exposed to air further groove and be vulnerable to pollution, so as to be easily caused the generation of blood sampling accident.

Sealing the plug of test tube and lid simultaneously needs Jing two procedures just can be assembled to test tube up, increased and produces into This.

In addition, be often only that tens heparin tubes are consumed in China, and due to being all single use, the process of medical waste Cause huge fund input.And for used heparin tube, the independent recycling cost of wherein rubber stopper compares lid The recycling cost of plastics is higher.In the production link of heparin tube, the usage amount of rubber how is reduced, while not affecting to adopt The sealing property and performance of blood vessel, or even strengthen these performances, remain the aspect having much room for improvement in heparin tube production.

The content of the invention

The technical problem to be solved is the defect for overcoming prior art, there is provided one kind is used for heparin tube, blood sampling The lid of pipe is integrally formed with plug, using special construction, reduces plug cost so as to reduce production cost, user Just, safety.

According to the first embodiment of the present invention, the heparin tube that the present invention is provided is made up of closure and test tube, is sealed Lid is made up of lid, plug.Preferably, lid is shaped with plug using two-shot molding process, first by lid integrated injection molding Shaping, then by plug mould filling in lid." double-colored " described here refers to plug rubber with lid plastics in color Difference.Co-injection or double-shot moulding are the technologies commonly used in rubber and plastic applications, but, have no in the manufacture of heparin tube Report adopts this technology.

Lid 1 from test tube with lower chambers 11, the upper chamber 14, the step 12 and from epicoele ceiling that accommodate plug plug hat The perforate 13 of tube-shaped that end is downwardly extending is constituted, and perforate 13 is collectively forming a groove with plug top, its effect with it is existing There is the groove 13 (referring to accompanying drawing 1) on technology plug identical.

Preferably, the lower end of tube-shaped perforate 13 be bumped in plug 2 cause spool lower end inner and outer wall all with glue Plug rubber contact, wherein plug are provided with corresponding groove 211 and ensure that both are closely joined together.It is further preferred that bobbin The lower end of shape perforate 13 is closely stretched in groove 211, is further adjacent to power between increase plug and inboard wall of test tube, improves sealing Performance.

Preferably, the end portion being bumped in plug of tube-shaped perforate 13 has raised or/and bending, or the lower end Part has the multiple perhaps multiple small barb structures on being distributed in bobbin inwall and/or outer wall or micro serrations structure. Such design improves the easiness that plug is extracted from test tube, there is provided using upper convenience, that is, be beneficial to lid with Plug transfers to together test tube.

Plug is made up of the plug neck 22 and plug hat 23 for sealing test tube, and plug neck coordinates with test tube sealing, and plug neck is filled in lid Upper chamber in.This structure reduces the materials of plug plug crown moieties, so as to reduce plug cost.

According to the second embodiment of the present invention, on the basis of first embodiment, lid 1 cancels upper chamber, The bobbin of perforate 13 extends downwards upwards simultaneously from from step 12 (now the position of step 12 becomes the top of lid), plug 2 also cancel 23 parts of plug hat, only retain plug neck 22, and the materials of such plug are less, and cost is lower.

In the same manner as first embodiment, in second embodiment preferably, the lower end of tube-shaped perforate 13 Be bumped in plug 2 cause the inwall or outer wall of spool lower end all with rubber contact, wherein plug is provided with corresponding groove 211 and protects Both cards are closely joined together.It is further preferred that the lower end of tube-shaped perforate 13 is closely stretched in groove 211, further increase Power is adjacent between large rubber plug and inboard wall of test tube, sealing property is improved.Preferably, tube-shaped perforate 13 is bumped in plug End portion has a raised or/and bending, or the end portion have be distributed on bobbin inwall and/or outer wall it is multiple perhaps Multiple small barb structure or micro serrations structure.Such design improves the easiness that plug extracts from test tube and can By property, there is provided using upper convenience.

Further, perforate 13 is sealed by diaphragm seal 3 on closure 10, and diaphragm seal 3 can be by welding or being bonded in lid 1 On, and the perforate 13 at the top of lid is fully sealed.Diaphragm seal is easily tore film, when in use, can be by it from heparin tube with hand Tear in lid.Also sealing 15 can be designed in lid and carrys out seal and opening 13, be provided with easily in sealing 15 and perforate junction In folding or the/weak point 151 that twists off, it is ensured that in heparin tube using front, staff's hand can remove sealing folding, expose Perforate 13 and plug, conveniently carry out blood sampling work.The face shaping of sealing (or upper part of sealing) can be to be easy to use hand Grip variously-shaped is easy to the obform body that is variously-shaped or being easy to finger grip pinched with finger.Such as：Sealing The outline of cross section is presented circular, oval, square or similar circular, similar oval, similar square shape.Together Sample, sealing (or upper part of sealing) can be solid or hollow.Using the heparin tube of this structure, it is ensured that open Hole 13 and plug exposed portion using it is front will not by environment in unclean air polluted.

In the present invention, for the raw material of plug has no particular limits, the plug of heparin tube is usually used in prior art In rubber raw materials (such as butyl rubber or natural rubber, preferred butyl rubber) can be used in the present invention.In addition, for pipe The raw material of lid is not particularly limited, and the raw material being usually used in prior art in the lid of heparin tube can be used in the present invention.

" optional " expression in this application is with or without, or expression is carried out or do not carried out.

Various embodiments of the present invention are summarized as follows：

1st, a kind of heparin tube, including lid（1）, plug（2）And test tube（3）, it is characterised in that plug（2）Including lower end Plug neck (22), the plug hat of upper end（23）Optionally in plug neck (22) and plug hat（23）The changeover portion (24) for existing between the two, pipe Lid（1）Including with test tube（3）The lower chambers of cooperation（11）, positioned at lid（1）Inwall on step（12）(can be continuous Annular or discrete annular, preferably continuous annular), above step (12) for accommodating plug plug hat（23）'s Upper chamber（14）With from lid（1）Top (or upper chamber（14）Top) extend downward the cylinder that plug neck (22) top is formed Tubular perforate（13）, and perforate（13）A groove is collectively forming with plug neck (22) top；Wherein, neck (22) and optional is filled in Changeover portion (24) coordinates with test tube (3) sealing, and plug hat（23）In being filled in the upper chamber of lid.

Upper chamber is by lid（1）Upper end, lid（1）Top and tube-shaped perforate（13）Upper end constitute.Under Together.

2nd, the heparin tube according to 1 above, it is characterised in that tube-shaped perforate（13）Lower end inlay further downward Enter plug（2）Plug neck (22) groove（211）Among.

3rd, according to the heparin tube of 2 above, the lower end of wherein tube-shaped perforate (13) is closely bumped in groove (211), enters One step to increase and be adjacent to power between plug and inboard wall of test tube.

4th, according to the heparin tube of the above 2 or 3, wherein tube-shaped perforate（13）Lower end be bumped into plug neck (22) groove （211）Among that part be that there is the first inner edge (32) and/or Basolateral to have for bottom inner side of " being bumped into part " One outer rim (accompanying drawing is not drawn into)；

And/or

In tube-shaped perforate（13）Lower end be bumped into plug neck (22) groove（211）Among that part " be bumped into portion Point " inner side and/or outside on distributed multiple perhaps multiple (such as 2-20, more preferably 4-15, preferred 6-10) It is raised.

In this application, any inner edge (such as inner edge 32) or any outer rim can be continuous annular or discrete rings Shape, preferably continuous annular.Similarly hereinafter.

5th, according to the heparin tube of any one in 4 above, wherein the bottom inner side for being bumped into part has in the first inner edge (32) the second inner edge on and/or this be bumped into the Basolateral of part and there is the second outer rim on the first outer rim.

6th, the heparin tube of 4 or 5 according to more than, its protrusions are miniature acclivitous barb structure or miniature saw Toothing or miniature mound point.

7th, according to the heparin tube of any one in above 1-6 item, wherein the external diameter of tube-shaped perforate (13) is equivalent to test tube The 60-92% of internal diameter, more preferably preferred 70-88%, 75-85%, such as 80%.

8th, according to the heparin tube of any one in above 1-7 item, wherein the plug plug hat on step (12)（23） Height equivalent to plug neck (22) height 5-40%, more preferably preferred 6-30%, more preferably 8-20%, 10-18%.

9th, according to the heparin tube of any one in above 1-8 item, wherein tube-shaped perforate（13）Lower end be further bumped into Plug（2）Plug neck (22) among depth equivalent to plug neck (22) height 40-90%, more preferably preferred 50-85%, 55- 80%, more preferably 60-75%.

10th, a kind of heparin tube, it includes lid（1）, plug（2）And test tube（3）, it is characterised in that lid（1）Including with Test tube（3）The lower chambers of cooperation（11）With the perforate of the tube-shaped extended up and down from the top of lid (1) simultaneously（13） (or the upper and lower tube-shaped perforate through lid (1) top（13）), the wherein perforate of tube-shaped（13）The lower end edge for extending downwardly Enter plug（2）Groove (211) among, and the perforate of tube-shaped（13）Upwardly extending upper end is total to the top of plug (2) With one groove of formation；Wherein, plug (2) coordinates with test tube (3) sealing.

11st, according to the heparin tube of 10 above, the lower end of wherein tube-shaped perforate (13) is closely bumped into plug（2）Groove (211) among, further it is adjacent to power between increase plug and inboard wall of test tube.

12nd, according to the heparin tube of 10 or 11 above, wherein tube-shaped perforate（13）Lower end be bumped into plug neck (22) ditch Groove（211）Among that part be that there is the first inner edge (32) and/or Basolateral to have for bottom inner side of " being bumped into part " First outer rim (not shown)；

And/or

13rd, according to the heparin tube of any one in above 10-12 item, wherein the bottom inner side for being bumped into part has first The second inner edge on inner edge (32) and/or this be bumped into the Basolateral of part and there is the second outer rim on the first outer rim.

14th, according to the heparin tube of 12 or 13 above, its protrusions is miniature acclivitous barb structure or miniature Broached-tooth design or miniature mound point.

15th, according to the heparin tube of any one in above 10-14 item, wherein the external diameter of tube-shaped perforate (13) is equivalent to examination The 60-92% of bore, more preferably preferred 70-88%, 75-85%, such as 80%.

16th, according to the heparin tube of any one in above 10-15 item, wherein tube-shaped perforate（13）Lower end further inlay Enter plug（2）Plug neck (22) among depth equivalent to plug neck (22) height 40-90%, preferred 50-85%, more preferably 55-80%, more preferably 60-75%.

17th, a kind of heparin tube, including lid（1）, plug（2）And test tube（3）, it is characterised in that plug（2）Including lower end Plug neck (22) and upper end plug hat（23）The changeover portion (24) for optionally existing therebetween, lid（1）Including with test tube （3）The lower chambers of cooperation（11）, accommodate plug plug hat（23）Upper chamber（14）With top (or the upper chamber from lid (1) （14）Top) extend downwardly and be bumped into plug（2）Plug neck (22) groove (211) among tube-shaped perforate（13）, and Perforate（13）A groove is collectively forming with plug neck (22) top；Wherein, fill in neck (22) and the changeover portion (24) that is optionally present and try Pipe (3) sealing coordinates, plug hat（23）It is filled in the upper chamber of lid and fills in hat（23）Outer radius it is outer with plug neck (22) The difference of radius equivalent to the middle upper end pipe thickness of test tube 30-70%, preferred 40-60%, such as about 50%.

18th, according to the heparin tube of 17 above, the lower end of wherein tube-shaped perforate (13) is closely bumped into plug（2）Plug neck (22) among groove (211), further it is adjacent to power between increase plug and inboard wall of test tube.

19th, according to the heparin tube of 17 or 18 above, wherein tube-shaped perforate（13）Lower end be bumped into plug neck (22) ditch Groove（211）Among that part be that there is the first inner edge (32) and/or Basolateral to have for bottom inner side of " being bumped into part " First outer rim (not shown)；

And/or

20th, according to the heparin tube of any one in above 17-19 item, wherein the bottom inner side for being bumped into part has first The second inner edge on inner edge (32) and/or this be bumped into the Basolateral of part and there is the second outer rim on the first outer rim.

21st, according to the heparin tube of 19 or 20 above, its protrusions is miniature acclivitous barb structure or miniature Broached-tooth design or miniature mound point.

22nd, according to the heparin tube of any one in above 17-21 item, wherein the external diameter of tube-shaped perforate (13) is equivalent to examination The 60-92% of bore, more preferably preferred 70-88%, 75-85%, such as 80%.

23rd, according to the heparin tube of any one in above 17-22 item, wherein plug plug is preced with（23）Height equivalent to plug neck (22) 40-90% of height, more preferably preferred 45-85%, more preferably 50-80%, more preferably 55-75%, 60-70%.

24th, according to the heparin tube of any one in above 17-23 item, wherein tube-shaped perforate（13）Lower end further inlay Enter plug（2）Plug neck (22) groove (211) among depth equivalent to plug neck (22) height 40-90%, preferred 50- 85%, more preferably 55-80%, more preferably 60-75%.

25th, according to the heparin tube of any one in above 1-24 item, it is characterised in that lid（1）Upper perforate（13）Upper end Mouth is by diaphragm seal（4）Sealing.

26th, according to the heparin tube of 25 above, wherein diaphragm seal（4）By welding or lid can be bonded in（1）Top Or perforate（13）Upper end, wherein diaphragm seal（4）By the perforate at the top of lid（13）Fully seal；Preferably, diaphragm seal is Easily tore film.When in use, will can be torn in its lid from heparin tube with hand.

27th, according to the heparin tube of any one in above 1-24 item, wherein designing sealing 15 in lid to seal out Hole 13, is provided with sealing 15 and perforate junction and is easy to roll over or/the weak point 151 that twists off.So design purpose be, it is ensured that In heparin tube using front, sealing folding be removed by staff's hand, expose perforate 13 and plug, conveniently carry out blood sampling work Make.

28th, according to the heparin tube of 27 above, the face shaping of wherein sealing (or upper part of sealing) can be easy In hold with a hand variously-shaped or it is easy to the obform body that is variously-shaped or being easy to finger grip pinched with finger.

29th, according to the heparin tube of 27 or 28 above, the wherein outline of the cross section of sealing presents circular, oval Shape, square, triangle or similar circular, similar oval, similar square or similar triangle shape.

30th, according to the heparin tube of any one in above 27-29 item, the wherein upper part of sealing or the sealing can be with It is solid or hollow.

31st, according to the heparin tube of any one in above 1-30 item, wherein tube-shaped perforate（13）It is bumped into plug（2）'s That part in the groove 211 of groove 211 or plug neck (22) is that " being bumped into part " has flexural deformation, example on longitudinally or axially Such as S-shaped deformation, the deformation of local external drum or local inner concave deformation.

In the present invention, in spite of there is plug hat (23), plug neck (22) can reach good sealing effectiveness, in passing through Test is revealed specified in magnificent people's republic's pharmaceuticals industry standard YY0314-2007, fluorescence is can't detect, meeting standard will Ask.

Advantages of the present invention：

Several structures using more than, the materials of plug part will greatly reduce, and most preferably scheme can reduce by 50% rubber Glue materials.The consumption of Chinese 1 year heparin tube is tens, and the speed according to annual 21.6% is increasing, using this The heparin tube of bright this technology manufacture, will greatly save resource, and pipe is compared in reduces cost, the in addition recycling of plug scrap rubber The recycling of lid plastics needs higher post processing cost recovery.In addition, reducing the consumption of plug (rubber), significantly reducing While cost, it is ensured that the sealing property of heparin tube, or even also enhance sealing property.Further, improve and use Convenience such as extracts performance.Due to reducing the volume of plug hat or not even being preced with using plug, in order to further improve sealing, can Somewhat to increase the height of plug neck.

Scheme above is that those skilled in the art are not readily conceivable that, nor be able to can be associated according to other field The design of this area.It is achieved simultaneously in the present invention:On the one hand the rubber consumption of plug is reduced, does not on the other hand affect close Sealing property and performance.

In the present invention rubber plug can by with other elastomeric materials be made plug substitute.

Description of the drawings

Fig. 1 is the structural representation of prior art heparin tube；

The structural representation of the lid adopted in the prior art heparin tube that Fig. 2 is；

Fig. 3 is the structural representation of the plug 2 adopted in prior art heparin tube；

Fig. 4 is the structural representation of the embodiment 1 of the heparin tube of the present invention；

Fig. 5 be heparin tube of the present invention embodiment 1 in the structural representation of lid that adopts；

Fig. 6 be heparin tube of the present invention embodiment 1 in the structural representation of plug 2 that adopts；

Fig. 7 is the structural representation of the embodiment 2 of heparin tube of the present invention；

Fig. 8 be heparin tube of the present invention embodiment 2 in the structural representation of lid that adopts；

Fig. 9 be heparin tube of the present invention embodiment 2 in the structural representation of plug 2 that adopts；

Figure 10 is the structural representation of the embodiment 3 of heparin tube of the present invention；

Figure 11 be heparin tube of the present invention embodiment 3 in the structural representation of lid that adopts；

Figure 12 be heparin tube of the present invention embodiment 3 in the structural representation of lid that adopts；

Figure 13 is the structural representation of the embodiment 4 of heparin tube of the present invention；

Figure 14 be heparin tube of the present invention embodiment 4 in the top view of lid that adopts；

Figure 15 be heparin tube of the present invention embodiment 4 in the top view of lid that adopts；

Figure 16 is the structural representation of the embodiment 5 of heparin tube of the present invention；

Figure 17 be heparin tube of the present invention embodiment 5 in the structural representation of lid that adopts；

Figure 18 be heparin tube of the present invention embodiment 5 in the top view of lid 1 that adopts；

Figure 19 is the structural representation of the embodiment 6 of heparin tube of the present invention；

Figure 20 be heparin tube of the present invention embodiment 6 in the structural representation of closure 1 that adopts；

Figure 21 be heparin tube of the present invention embodiment 6 in the structural representation of lid that adopts；

Figure 22 is the structural representation of the embodiment 7 of heparin tube of the present invention；

Figure 23 is the structural representation of the embodiment 8 of heparin tube of the present invention；

Figure 24 be heparin tube of the present invention embodiment 8 in the structural representation of closure 1 that adopts；

Figure 25 be heparin tube of the present invention embodiment 8 in the top view of closure that adopts；

Figure 26 is the structural representation of the embodiment 9 of heparin tube of the present invention；

Figure 27 is the structural representation of the embodiment 10 of heparin tube of the present invention；

Figure 28 be heparin tube of the present invention embodiment 10 in the structural representation of lid that adopts；

Figure 29 be heparin tube of the present invention embodiment 10 in the structural representation of plug 2 that adopts；

Figure 30 is the structural representation of the embodiment 11 of heparin tube of the present invention；

Figure 31 be heparin tube of the present invention embodiment 11 in the structural representation of lid that adopts；

Figure 32 be heparin tube of the present invention embodiment 11 in the structural representation of plug 2 that adopts；

Figure 33 is the structural representation of the embodiment 13 of heparin tube of the present invention；

Figure 34 be heparin tube of the present invention embodiment 13 in the structural representation of lid that adopts；

Figure 35 be heparin tube of the present invention embodiment 13 in the structural representation of plug 2 that adopts；

Mark in accompanying drawing is represented：

1st, lid 2, plug 3, test tube 4, diaphragm seal 11, lower chambers 12, step 13, perforate 14, upper chamber 15, Sealing 22, plug neck 23, plug hat 24, changeover portion 32, inner edge 33, bending 151, weak point 211, groove

Specific embodiment

As the raw material of plug in embodiments herein, can be using butyl rubber or natural rubber, with butyl rubber Citing.

Embodiment 1

As Figure 4-Figure 6, heparin tube is made up of lid 1, plug 2 and test tube 3；Lid from test tube with lower chambers 11st, 13 groups of the perforate of the upper chamber 14, step 12 and the tube-shaped being downwardly extending from upper chamber top of plug plug hat is accommodated Into, a groove is collectively forming at the top of perforate 13 and the plug neck (22) of plug 2, it is acted on and the groove 13 on prior art plug It is identical.The height for wherein filling in neck (22) is 6.0mm, and, wherein outer (straight) footpath of tube-shaped perforate (13) is equivalent in test tube About the 76% of (straight) footpath, and plug hat（23）Height equivalent to plug neck (22) height about 13%.

Embodiment 2

As Figure 7-9, heparin tube is made up of lid 1, plug 2 and test tube 3；Lid from test tube with lower chambers 11st, 13 groups of the perforate of the upper chamber 14, step 12 and the tube-shaped being downwardly extending from upper chamber top of plug plug hat is accommodated Into, a groove is collectively forming at the top of perforate 13 and the plug neck (22) of plug 2, it is acted on and the groove 13 on prior art plug It is identical.The tube wall of perforate 13 is bumped in plug 2, and plug is provided with corresponding groove 211 and ensures that both are closely joined together.With Test tube is transferred to together with plug beneficial to lid.The height for wherein filling in neck (22) is 6.0mm, and wherein tube-shaped perforate (13) is outer (straight) footpath is equivalent to about 76% of (straight) footpath in test tube, and plug hat（23）Height equivalent to plug neck (22) height pact 15%.Additionally, the tube wall of perforate 13 is bumped into about the 60% of height of the depth in plug 2 equivalent to plug neck (22).

Embodiment 3

As shown in figs. 10-12, heparin tube is made up of lid 1, plug 2 and test tube 3；Lid from test tube with lower chambers 11st, 13 groups of the perforate of the upper chamber 14, step 12 and the tube-shaped being downwardly extending from upper chamber top of plug plug hat is accommodated Into, a groove is collectively forming at the top of perforate 13 and the plug neck of plug 2, it is acted on and the phase of groove 13 on prior art plug Together.Perforate 13 in lid is sealed by diaphragm seal 3, and diaphragm seal 3 by welding or can be bonded in lid 1, and by the top of lid Perforate 13 fully seal.Diaphragm seal is easily tore film, when in use, will can be torn in its lid from heparin tube with hand.Wherein The height of plug neck (22) is about 5.0mm, and wherein outer (straight) footpath of tube-shaped perforate (13) is equivalent to (straight) footpath in test tube About 76%, and plug hat（23）Height equivalent to plug neck (22) height about 17%.

Embodiment 4

As illustrated in figs. 13-15, heparin tube is made up of lid 1, plug 2 and test tube 3；Lid from test tube with lower chambers 11st, 13 groups of the perforate of the upper chamber 14, step 12 and the tube-shaped being downwardly extending from upper chamber top of plug plug hat is accommodated Into, a groove is collectively forming at the top of perforate 13 and the plug neck of plug 2, it is acted on and the phase of groove 13 on prior art plug Together.The sealing 15 for designing in lid as shown in FIG. 14 and 15 carrys out the upper port of seal and opening 13, in sealing 15 and perforate 13 junctions are provided with and are easy to folding（Turn round）Disconnected weak point 151, it is ensured that in heparin tube using front, staff's hand can will be close Envelope portion folding is removed, and exposes perforate 13 and plug, conveniently carries out blood sampling work.The outer contour shape of the cross section of sealing is ellipse Shape, with diameter greater than groove diameter.The height for wherein filling in neck (22) is 5.0mm, and wherein outer (straight) footpath of tube-shaped perforate (13) Equivalent to about 76% of (straight) footpath in test tube, and plug hat（23）Height equivalent to plug neck (22) height about 17%.

Embodiment 5

As shown in figs. 16-18, heparin tube is made up of lid 1, plug 2 and test tube 3；Lid from test tube with lower chambers 11st, 13 groups of the perforate of the upper chamber 14, step 12 and the tube-shaped being downwardly extending from upper chamber top of plug plug hat is accommodated Into, a groove is collectively forming at the top of perforate 13 and the plug neck of plug 2, it is acted on and the phase of groove 13 on prior art plug Together.The sealing 15 for designing in lid as shown in FIG. 17 and 18 carrys out seal and opening 13, in sealing 15 and the junction of perforate 13 It is provided with and is easy to folding（Turn round）Disconnected weak point 151, it is ensured that in heparin tube using front, roll over sealing by staff's hand Remove, expose perforate 13 and plug, conveniently carry out blood sampling work.The outer contour shape of the cross section of sealing is circle, and diameter is firm Good energy sealed groove.The sealing is hollow or solid.The height for wherein filling in neck (22) is 5.0mm, and its middle bobbin Outer (straight) footpath of shape perforate (13) is equivalent to about 76% of (straight) footpath in test tube, and plug hat（23）Height equivalent to plug neck (22) about the 15% of height.

Embodiment 6

As shown in figs. 19-21, heparin tube is made up of closure and test tube, and closure is made up of lid, plug；Lid and glue Plug is shaped using two-shot molding process, first shapes lid integrated injection molding, then by plug mould filling in lid.Lid 1 From with test tube with lower chambers 11, accommodate plug plug hat upper chamber 14, step 12 and from upper chamber top extend downwardly shape Into the perforate 13 of tube-shaped constitute, be collectively forming a groove at the top of perforate 13 and the plug neck (22) of plug, its effect and existing There is the groove 13 on technology plug identical.The tube wall of perforate is bumped in the plug neck (22) of plug 2, and plug is provided with corresponding ditch Groove 211 ensures that both are closely joined together.Wherein plug is preced with（23）Outer radius and plug neck (22) outer radius difference equivalent to About the 50% of the middle upper end pipe thickness of test tube, and the height of wherein plug neck (22) is 6.0mm.And, wherein tube-shaped perforate (13) external diameter is equivalent to about the 80% of test tube internal diameter, and plug plug hat（23）Height equivalent to plug neck (22) height pact 60%, and tube-shaped perforate（13）Lower end be further bumped into plug（2）Plug neck (22) groove (211) among depth phase When about 75% of the height in plug neck (22).

Embodiment 7

As shown in figure 22, heparin tube is made up of closure and test tube, and closure is made up of lid, plug；Lid and plug Shaped using two-shot molding process, first shape lid integrated injection molding, then by plug mould filling in lid.Heparin tube bag Include lid（1）, plug（2）And test tube（3）, wherein lid（1）Including with test tube（3）The lower chambers of cooperation（11）With from lid (1) perforate of the tube-shaped that top extends up and down simultaneously（13）, the wherein perforate of tube-shaped（13）Extend downwardly Hypomere is bumped into plug（2）Groove (211) among, and the perforate of tube-shaped（13）Upwardly extending epimere and plug (2) Top is collectively forming a groove；Wherein, plug (2) coordinates with test tube (3) sealing.

The height of wherein plug (2) is 6.0mm, the external diameter of tube-shaped perforate (13) equivalent to about the 75% of test tube internal diameter, and Tube-shaped perforate（13）Hypomere be further bumped into plug（2）Groove (211) among depth equivalent to plug (2) height About 76%.

Embodiment 8

As shown in figs. 23-25, heparin tube is made up of closure and test tube, and closure is made up of lid, plug；Lid and glue Plug is shaped using two-shot molding process, first shapes lid integrated injection molding, then by plug mould filling in lid.

Heparin tube includes lid（1）, plug（2）And test tube（3）, wherein plug（2）Plug neck (22) including lower end and upper The plug hat at end（23）, lid（1）Including with test tube（3）The lower chambers of cooperation（11）, accommodate plug plug hat（23）Upper chamber （14）Plug is extended downwardly and is bumped into from the top of lid (1)（2）Plug neck (22) groove (211) among tube-shaped open Hole（13）, and perforate（13）A groove is collectively forming with plug neck (22) top；Wherein, fill in neck (22) to match somebody with somebody with test tube (3) sealing Close, plug hat（23）In being filled in the upper chamber of lid.

Wherein plug is preced with（23）Outer radius and plug neck (22) outer radius difference equivalent to test tube middle epimere pipe thickness About 50%, and wherein fill in neck (22) height be 5.5mm.And, wherein the external diameter of tube-shaped perforate (13) is equivalent to test tube About the 80% of internal diameter, and plug plug hat（23）Height equivalent to about the 60% of the height of plug neck (22), and tube-shaped perforate（13） Lower end be further bumped into plug（2）Plug neck (22) groove (211) among depth equivalent to plug neck (22) height About 70%.

The top of perforate 13 of lid is sealed by diaphragm seal 3, and diaphragm seal 3 by welding or can be bonded in lid 1, and will pipe The perforate 13 of tops is fully sealed.Diaphragm seal is easily tore film, when in use, will can be torn in its lid from heparin tube with hand Fall.

Embodiment 9

As shown in figure 26, heparin tube is made up of closure and test tube, and closure is made up of lid, plug；Lid and plug Shaped using two-shot molding process, first shape lid integrated injection molding, then by plug mould filling in lid.

Heparin tube includes lid（1）, plug（2）And test tube（3）, wherein lid（1）Including with test tube（3）The cavity of resorption of cooperation Room（11）With the perforate of the tube-shaped extended up and down from the top of lid (1) simultaneously（13）, the wherein perforate of tube-shaped （13）The hypomere for extending downwardly is bumped into plug（2）Groove (211) among, and the perforate of tube-shaped（13）On upwardly extending A groove is collectively forming at the top of section and plug (2)；Wherein, plug (2) coordinates with test tube (3) sealing.

Wherein the upper port of perforate 13 is sealed by diaphragm seal 3, and diaphragm seal 3 by welding or can be bonded in lid 1, and will Perforate 13 at the top of lid is fully sealed.Diaphragm seal is easily tore film, when in use, will can be torn in its lid from heparin tube with hand Fall.

Embodiment 10

As can be seen in figures from 27 to 29, heparin tube includes lid（1）, plug（2）And test tube（3）, wherein lid（1）Including with examination Pipe（3）The lower chambers of cooperation（11）With the perforate of the tube-shaped extended up and down from the top of lid (1) simultaneously（13）, its The perforate of middle bobbin shape（13）The hypomere for extending downwardly is bumped into plug（2）Groove (211) among, and the perforate of tube-shaped （13）A groove is collectively forming at the top of upwardly extending epimere and plug (2)；Wherein, plug (2) is matched somebody with somebody with test tube (3) sealing Close.

Wherein tube-shaped perforate（13）Lower end be bumped into plug neck (22) groove（211）Among that part " be bumped into The bottom inner side of part " has the first inner edge (32), and the latter is continuous annular or discrete annular.

Embodiment 11

It is substantially the same with embodiment 2 (as Figure 7-9), simply tube-shaped perforate（13）Lower end be bumped into plug neck (22) Groove（211）Among " being bumped into part " bottom inner side have the first inner edge (32) (as shown in Figure 30-32), Hou Zheshi Continuous or continuous annular.

Embodiment 12

Substantially the same with embodiment 7 (as shown in figure 22), simply bobbin is bumped into " being bumped into part " in plug outside it There is the projection of the thorn-like of many (8) on wall.

Embodiment 13

Substantially the same with embodiment 6 (as shown in figs. 19-21), simply bobbin is bumped into " being bumped into part " in plug at it There is flexural deformation on longitudinal direction（33）(as shown in figs. 33-35).

Embodiment 14

Substantially the same with embodiment 5, simply the outer contour shape of the cross section of sealing is oval.Sealing is same Sample can be hollow or solid.

Embodiment 15

Substantially the same with embodiment 5, simply the outer contour shape of the cross section of sealing is square.Sealing is same Can be hollow or solid.

Experimental section

1st, insert, extract the test of performance

Using the heparin tube of each embodiment of the invention, by lid and the partial insertion test tube of plug, lid and plug energy It is enough smoothly to extract from test tube；Repeat said process 10 times, plug still can be extracted smoothly, and without crack and damage It is bad, without rupturing, subside, rupture or other visible damages.Illustrate that perforate can combine closely with plug.In addition, in tube-shaped The outer wall of perforate and the inwall of lid between have clamping force to plug top, be conducive to extracting plug.Especially, in tube-shaped When perforate is bumped into the end portion in plug and has raised (such as the projection of thorn-like, or inner edge or outer rim), it is more beneficial for extracting Plug.

2nd, pipe plug of taking a blood sample reveals test

Heparin tube in the above-described embodiments is adopted according to People's Republic of China's pharmaceuticals industry standard YY0314-2007 What the leakage of blood vessel stopper was tested wants condition for peace, is suitable for the instrument of regulation, it then follows the test procedure of regulation is tested, the present invention In each scheme can reach the requirement of standard, inspection does not measure fluorescence.

3rd, the test of sealing property

10 are taken in the heparin tube of above-described embodiment and is only used as a collection of sample, while the heparin tube for choosing prior art is (every Batch it is also 10) as a comparison, to number respectively, every heparin tube capacity of the application and prior art is 4ml, per only taking a blood sample Pipe loads 2.000g ± 0.2mg drier after lid and plug is removed in test tube, and (it is anhydrous by with the addition of micro blueness The microgranular Bibulous Silica Gel of sulfuric acid cobalt salt crushed, sieve and and then heat 2 hours in the baking oven of 170-190, after taking-up Seal immediately, obtain after cooling, quick to weigh), load the test tube and its lid and plug of each batch of heparin tube of drier It is placed in vacuum tank together and vacuumizes, respective lid is covered on test tube and allows plug to seal test tube, uses assay balance (precision 0.1mg) is weighed per batch Initial total weight of 10 charging heparin tubes.The sample of each batch is all in constant temperature and humidity container (25 DEG C, 50% relative humidity) are placed 90 days, observe after taking-up and ruddy appearance is not found in drier, use divide again Analysis balance weighs the quality (for assessment) of the drier poured out from every test tube per the gross weight and weighing of criticizing 10, obtains Obtain average weight increment (wt)/every heparin tube of each batch of heparin tube after a period of time is placed.

Concrete outcome is referring to table 1 below：

Table 1

Embodiment No	Average weight increment, mg
		1	5.4
2	2.8
		3	3.2
8	1.5
		9	1.8
10	3.4
		11	2.7
The heparin tube 1 of prior art	7.8
		The heparin tube 2 of prior art	6.8

Above example 1 compared with the result of embodiment 8, is indicated with the results contrast of embodiment 2 and embodiment 3 The perforate (13) of tube-shaped is bumped into be further increased in plug (2) and be adjacent to power between plug and inboard wall of test tube, so as to carry High sealing.

Claims

1. a kind of heparin tube, including lid（1）, plug（2）And test tube（3）, it is characterised in that plug（2）Including the plug neck of lower end (22), the plug hat of upper end（23）Optionally in plug neck (22) and plug hat（23）The changeover portion (24) for existing between the two, lid（1） Including with test tube（3）The lower chambers of cooperation（11）, positioned at lid（1）Inwall on step（12）, positioned at step (12) top For accommodate plug plug hat（23）Upper chamber（14）With from lid（1）Top extend downward plug neck (22) top institute shape Into tube-shaped perforate（13）, and perforate（13）A groove is collectively forming with plug neck (22) top；Wherein, fill in neck (22) and Optional changeover portion (24) coordinates with test tube (3) sealing, and plug hat（23）In being filled in the upper chamber of lid, tube-shaped perforate （13）Lower end be bumped into plug further downward（2）Plug neck (22) groove（211）Among；

Wherein：Rubber raw materials in plug are butyl rubber or natural rubber.

2. heparin tube according to claim 1, the lower end of wherein tube-shaped perforate (13) is closely bumped in groove (211), enters one Power is adjacent between step increase plug and inboard wall of test tube.

3. according to the heparin tube of claim 1 or 2, wherein tube-shaped perforate（13）Lower end be bumped into plug neck (22) groove （211）Among that part be that there is the first inner edge (32) and/or Basolateral to have for bottom inner side of " being bumped into part " One outer rim；

And/or

In tube-shaped perforate（13）Lower end be bumped into plug neck (22) groove（211）Among that part be " be bumped into part " Multiple projections are distributed on inner side and/or outside.

4. heparin tube according to claim 3, wherein be bumped into the bottom of part inner side have on the first inner edge (32) the Two inner edges and/or this be bumped into the Basolateral of part and there is the second outer rim on the first outer rim.

5. heparin tube according to claim 3, its protrusions are miniature acclivitous barb structure or miniature sawtooth knot Structure or miniature mound point.

6. heparin tube according to claim 4, its protrusions are miniature acclivitous barb structure or miniature sawtooth knot Structure or miniature mound point.

7., according to the heparin tube of any one in claim 1,2 or 4-6, wherein the external diameter of tube-shaped perforate (13) is equivalent to examination The 60-92% of bore.

8. heparin tube according to claim 3, wherein 60-92% of the external diameter of tube-shaped perforate (13) equivalent to test tube internal diameter.

9. heparin tube according to claim 7, wherein 70-88% of the external diameter of tube-shaped perforate (13) equivalent to test tube internal diameter.

10. heparin tube according to claim 8, wherein 70-88% of the external diameter of tube-shaped perforate (13) equivalent to test tube internal diameter.

11. according to the heparin tube of claim 1 or 2, wherein the plug plug hat on step (12)（23）Height it is suitable In the 5-40% of the height of plug neck (22).

12. heparin tubes according to claim 11, wherein the plug plug hat on step (12)（23）Height equivalent to The 6-30% of the height of plug neck (22).

13. according to the heparin tube of claim 1 or 2, wherein tube-shaped perforate（13）Lower end be further bumped into plug（2）Plug 40-90% of the depth among neck (22) equivalent to the height of plug neck (22).

14. heparin tubes according to claim 13, wherein tube-shaped perforate（13）Lower end be further bumped into plug（2）Plug neck (22) 50-85% of the depth among equivalent to the height of plug neck (22).

A kind of 15. heparin tubes, it includes lid（1）, plug（2）And test tube（3）, it is characterised in that lid（1）Including with test tube （3）The lower chambers of cooperation（11）With the perforate of the tube-shaped extended up and down from the top of lid (1) simultaneously（13）, wherein The perforate of tube-shaped（13）The hypomere for extending downwardly is bumped into plug（2）Groove (211) among, and the perforate of tube-shaped（13） A groove is collectively forming at the top of upwardly extending epimere and plug (2)；Wherein, plug (2) coordinates with test tube (3) sealing；

Wherein：Rubber raw materials in plug are butyl rubber or natural rubber.

16. heparin tubes according to claim 15, the lower end of wherein tube-shaped perforate (13) is closely bumped into plug（2）Groove (211) among, further it is adjacent to power between increase plug and inboard wall of test tube.

17. according to the heparin tube of claim 15 or 16, wherein tube-shaped perforate（13）Lower end be bumped into plug neck (22) groove （211）Among that part be that there is the first inner edge (32) and/or Basolateral to have for bottom inner side of " being bumped into part " One outer rim；

And/or

18. heparin tubes according to claim 17, wherein in tube-shaped perforate（13）Lower end be bumped into plug neck (22) groove （211）Among that part be the projection that 2-20 is distributed on the inner side and/or outside of " being bumped into part ".

19. heparin tube according to claim 18, wherein in tube-shaped perforate（13）Lower end be bumped into plug neck (22) groove （211）Among that part be the projection that 4-15 is distributed on the inner side and/or outside of " being bumped into part ".

20. heparin tubes according to claim 17, wherein be bumped into the bottom of part inner side having on the first inner edge (32) Second inner edge and/or this be bumped into the Basolateral of part and there is the second outer rim on the first outer rim.

21. heparin tubes according to claim 17, its protrusions are miniature acclivitous barb structure or miniature sawtooth Structure or miniature mound point.

22. heparin tubes according to claim 20, its protrusions are miniature acclivitous barb structure or miniature sawtooth Structure or miniature mound point.

23. according to the heparin tube of any one in claim 15,16 or 18-22, wherein the external diameter phase of tube-shaped perforate (13) When in the 60-92% of test tube internal diameter.

24. heparin tubes according to claim 17, wherein 60-92% of the external diameter of tube-shaped perforate (13) equivalent to test tube internal diameter.

25. heparin tubes according to claim 23, wherein 70-88% of the external diameter of tube-shaped perforate (13) equivalent to test tube internal diameter.

26. heparin tubes according to claim 24, wherein 70-88% of the external diameter of tube-shaped perforate (13) equivalent to test tube internal diameter.

27. according to the heparin tube of claim 15 or 16, wherein tube-shaped perforate（13）Lower end be further bumped into plug（2）'s 40-90% of the depth among plug neck (22) equivalent to the height of plug neck (22).

28. heparin tubes according to claim 27, wherein tube-shaped perforate（13）Lower end be further bumped into plug（2）Plug neck (22) 50-85% of the depth among equivalent to the height of plug neck (22).

A kind of 29. heparin tubes, including lid（1）, plug（2）And test tube（3）, it is characterised in that plug（2）Including the plug of lower end The plug hat of neck (22) and upper end（23）Optionally in plug neck (22) and plug hat（23）The changeover portion (24) for existing between the two, lid （1）Including with test tube（3）The lower chambers of cooperation（11）, accommodate plug plug hat（23）Upper chamber（14）With the top from lid (1) End extends downwardly and is bumped into plug（2）Plug neck (22) groove (211) among tube-shaped perforate（13）, and perforate（13） A groove is collectively forming with plug neck (22) top；Wherein, the changeover portion (24) filled in neck (22) and be optionally present is sealed with test tube (3) Coordinate, plug hat（23）It is filled in the upper chamber of lid and fills in hat（23）Outer radius and plug neck (22) outer radius difference phase As the 30-70% of the middle epimere pipe thickness in test tube；

Wherein：Rubber raw materials in plug are butyl rubber or natural rubber.

30. heparin tubes according to claim 29, wherein plug hat（23）It is filled in the upper chamber of lid and fills in hat（23）'s 40-60% of the difference of the outer radius of outer radius and plug neck (22) equivalent to the middle epimere pipe thickness of test tube.

31. heparin tubes according to claim 29, the lower end of wherein tube-shaped perforate (13) is closely bumped into plug（2）Plug neck (22) among groove (211), further it is adjacent to power between increase plug and inboard wall of test tube.

32. according to the heparin tube of any one in claim 29-31, wherein tube-shaped perforate（13）Lower end be bumped into plug neck (22) groove（211）Among that a part be " being bumped into part " bottom inner side have the first inner edge (32) and/or bottom Outside has the first outer rim；

And/or

33. according to the heparin tube of claim 32, wherein in tube-shaped perforate（13）Lower end be bumped into plug neck (22) groove （211）Among that part be the projection that 2-20 is distributed on the inner side and/or outside of " being bumped into part ".

34. according to the heparin tube of claim 33, wherein in tube-shaped perforate（13）Lower end be bumped into plug neck (22) groove （211）Among that part be the projection that 4-15 is distributed on the inner side and/or outside of " being bumped into part ".

35. according to the heparin tube of claim 32, wherein be bumped into the bottom of part inner side having on the first inner edge (32) Second inner edge and/or this be bumped into the Basolateral of part and there is the second outer rim on the first outer rim.

36. according to the heparin tube of claim 32, and its protrusions is miniature acclivitous barb structure or miniature sawtooth Structure or miniature mound point.

37. according to the heparin tube of claim 35, and its protrusions is miniature acclivitous barb structure or miniature sawtooth Structure or miniature mound point.

38. according to the heparin tube of any one in claim 29-31 or 33-37, wherein the external diameter phase of tube-shaped perforate (13) When in the 60-92% of test tube internal diameter.

39. according to the heparin tube of claim 32, wherein 60-92% of the external diameter of tube-shaped perforate (13) equivalent to test tube internal diameter.

40. according to the heparin tube of claim 38, wherein 70-88% of the external diameter of tube-shaped perforate (13) equivalent to test tube internal diameter.

41. according to the heparin tube of claim 38, wherein 70-88% of the external diameter of tube-shaped perforate (13) equivalent to test tube internal diameter.

42. according to the heparin tube of any one in claim 29-31, wherein plug plug hat（23）Height equivalent to plug neck (22) 40-90% of height.

43. according to the heparin tube of claim 42, wherein plug plug hat（23）Height equivalent to plug neck (22) height 45- 85%。

44. according to the heparin tube of any one in claim 29-31, wherein tube-shaped perforate（13）Lower end be further bumped into Plug（2）Plug neck (22) groove (211) among depth equivalent to plug neck (22) height 40-90%.

45. according to the heparin tube of claim 44, wherein tube-shaped perforate（13）Lower end be further bumped into plug（2）Plug neck (22) 50-85% of the depth among groove (211) equivalent to the height of plug neck (22).

46. according to the heparin tube of any one in claim 1-2,15-16 or 29-31, it is characterised in that lid（1）Upper perforate （13）Upper port by diaphragm seal（4）Sealing.

47. according to the heparin tube of claim 46, wherein diaphragm seal（4）By welding or lid can be bonded in（1）Top or Perforate（13）Upper end, wherein diaphragm seal（4）By the perforate at the top of lid（13）Fully seal.

48. is easily tore film according to the heparin tube of claim 47, wherein diaphragm seal.

49. according to the heparin tube of any one in claim 1-2,15-16 or 29-31, wherein designing sealing in lid （15）Carry out seal and opening（13）, in sealing（15）It is provided with perforate junction and is easy to roll over or/the weak point that twists off（151）.

50. according to the heparin tube of claim 49, and wherein the face shaping of sealing can be easy to hold with a hand variously-shaped Or be easy to finger pinch it is variously-shaped.

51. can be easy to hold with a hand according to the heparin tube of claim 49, the face shaping of the wherein upper part of sealing It is variously-shaped or be easy to finger pinch it is variously-shaped.

52. according to the heparin tube of claim 50 or 51, and the face shaping of the wherein upper part of sealing can be to be easy to finger gripping The obform body held.

53. present circular, oval, square according to the heparin tube of claim 49, the wherein outline of the cross section of sealing Or the shape of triangle.

54. according to the heparin tube of claim 50 or 51, wherein the outline of the cross section of sealing present it is circular, oval, Square or triangle shape.

55. according to the heparin tube of claim 49, and the upper part of wherein sealing or the sealing is solid or hollow.

56. according to the heparin tube of claim 50,51 or 53, the upper part of wherein sealing or the sealing be it is solid or Hollow.

57. according to the heparin tube of claim 54, and the upper part of wherein sealing or the sealing is solid or hollow.

58. heparin tubes according to claim 3, wherein tube-shaped perforate（13）It is bumped into the groove of plug neck (22)（211）In That part is that " being bumped into part " has flexural deformation on longitudinally or axially.

59. heparin tubes according to claim 17, wherein tube-shaped perforate（13）It is bumped into the groove of plug neck (22)（211）In That part is that " being bumped into part " has flexural deformation on longitudinally or axially.

60. according to the heparin tube of claim 32, wherein tube-shaped perforate（13）It is bumped into the groove of plug neck (22)（211）In That part is that " being bumped into part " has flexural deformation on longitudinally or axially.

61. according to the heparin tube of claim 4,20 or 35, wherein tube-shaped perforate（13）It is bumped into the groove of plug neck (22) （211）In that part be that " being bumped into part " has flexural deformation on longitudinally or axially.

62. according to the heparin tube of any one in claim 58-60, wherein wherein tube-shaped perforate（13）It is bumped into plug neck (22) groove（211）In that part be " being bumped into part " have on longitudinally or axially S-shaped deformation, the deformation of local external drum or Local inner concave deforms.

63. according to the heparin tube of claim 61, wherein wherein tube-shaped perforate（13）It is bumped into the groove of plug neck (22)（211） In that part be that " being bumped into part " has S-shaped deformation, the deformation of local external drum or local inner concave deformation on longitudinally or axially.