CN104415379A - Iodine-125 sealed radioactive particle and preparation method thereof - Google Patents
Iodine-125 sealed radioactive particle and preparation method thereof Download PDFInfo
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- CN104415379A CN104415379A CN201310372700.9A CN201310372700A CN104415379A CN 104415379 A CN104415379 A CN 104415379A CN 201310372700 A CN201310372700 A CN 201310372700A CN 104415379 A CN104415379 A CN 104415379A
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Abstract
The invention belongs to the technical field of radiation medicine, and relates to an iodine-125 sealed radioactive particle and a preparation method thereof. The radioactive particle is prepared through wrapping an internal layer by an external layer, wherein the external layer is prepared by adopting silica gel, and the internal layer is a silica gel and radioactive iodine-125 mixture. The iodine-125 sealed radioactive particle overcomes the defects of the prior art, and does not need metallic titanium tubes and palladium wires or silver wires as raw materials, and the silica gel has no shielding effect, so the iodine-125 solution is saved, the cost is saved, and the environmental pollution is reduced; and the iodine-125 sealed radioactive particle can be used to prepare various specifications of particles in order to meet users' needs.
Description
Technical field
The invention belongs to radiological medicine technical field, relate to a kind of iodine-125 contained radioactivity particle and preparation method.
Background technology
At present, radiopharmaceutical as a kind of base therapy method, be widely used in clinical in; As the iodine-125 such as iodine-125, palladium-103 contained radioactivity seeds implanted treatment malignant tumor, be a kind of Therapeutic Method of Wicresoft, belong to closely internal radiotherapy; It has the advantages such as simple to operate, therapeutic effect is good, and clinical practice shows wide prospect.Said method widely uses in areas such as the U.S., Europe and Southeast Asia.Current, described iodine-125 contained radioactivity particle, abroad except the treatment being widely used in carcinoma of prostate, also achieves certain achievement to the research of the dissimilar oncotherapy in other positions; As glioblastoma, nonsmall-cell lung cancer etc.Along with the raising of living standards of the people, increasing people focuses on improving the quality of living, and increasing patient wishes to find new therapy approach to alleviate disease, extending life.Domestic existing Partial Hospitals takes the lead in seed source to be used for the oncotherapy of the organs such as liver, rectum, pancreas, esophagus, stomach, thyroid, mammary gland, prostate, follow up a case by regular visits to discovery have curative effect in various degree through following the tracks of, and this Therapeutic Method is just popularized rapidly at home, will by increasing medical personnel and patient understand and accept.
Because the use amount of described iodine-125 contained radioactivity particle grows with each passing day, volume of production rolls up thereupon, and therefore, batch production iodine-125 contained radioactivity particle has become inevitable; And the comfort level of the cost of natural iodine-125 contained radioactivity particle and Clinical practice just more and more by manufacturer and doctor pay attention to.The raw material of current iodine-125 contained radioactivity particle is except iodine-125 solution, and also have Titanium pipe and palladium silk or filamentary silver, above-mentioned raw material is all more valuable, and in order to meet the requirement such as purity and machining accuracy, at present, described raw material all must from external import; In addition, the iodine-125 contained radioactivity particle produced is accommodate by Titanium pipe and formed with the filamentary silver of radioactivity iodine-125 or palladium silk, about the self-shileding due to metal filamentary silver or palladium silk, therefore the iodine-125 solution of input about 1 times is needed could to obtain the particle of corresponding activity, cause the very large waste of iodine-125 solution, and not environmentally.
Therefore, present inventor intends providing a kind of iodine-125 contained radioactivity particle adopting silica gel to make; This radioactive particle can overcome the defect of prior art, Titanium pipe and palladium silk or filamentary silver need not be used to do raw material, and due to the unshielded effect of silica gel, appreciable iodine-125 solution can be saved, namely save cost and again reduce environmental pollution, the particle of all size can also be made simultaneously, meet user's needs.
Summary of the invention
The object of the invention is the defect and the deficiency that overcome prior art, a kind of iodine-125 contained radioactivity particle and preparation method are provided.
Iodine-125 contained radioactivity particle of the present invention, is characterized in that, is made up of outer 1 and internal layer 2; Described outer 1 wrapping inner layer 2;
In the present invention, described skin 1 adopts silica gel to make;
In the present invention, described internal layer 2 is the mixture of silica gel and radioactivity iodine-125.
Iodine-125 contained radioactivity particle of the present invention is prepared by following method, and it comprises step:
(1) liquid-state silicon gel 1 and silica gel 2 are got two equivalent to mix in beaker;
(2) getting appropriate normal octane adds in the mixture of above-mentioned silica gel, by three's mix homogeneously, and can pull out fine rule, make mixture A;
(3) identical mixture B is prepared again by above-mentioned same method, stand-by;
(4) said mixture A and mixture B is moved in the glove box with protection of sealing;
(5) size of the iodine-125 contained radioactivity particle activity prepared as required, adds the iodine-125 solution (specific activity is greater than 800mCi/ml) of high concentration in mixture A, and again by all substances mix homogeneously;
(6) mixture A being pulled into diameter is 0.5mm fine rule, then it is dried at the temperature of 70 degree;
(7) fine rule containing iodine-125 nucleic of drying is cut into the short silk that length is 3.3mm;
(8) the liquefied mixture B leaching above-mentioned short silk being placed in radioactivity I125 is put, and dries, make the sealing particle that inside is surrounded by iodine-125 nucleic with tweezers after pressing from both sides out under being again placed in the temperature of 70 degree.
Iodine-125 contained radioactivity particle of the present invention adopts silica gel to make; This radioactive particle overcomes the defect of prior art, and Titanium pipe and palladium silk or filamentary silver need not be used to do raw material, and due to the unshielded effect of silica gel, iodine-125 solution can be saved, namely saved cost and again reduced environmental pollution, the particle of all size can also have been made simultaneously, meet user's needs.
For the ease of understanding, below by the drawings and specific embodiments, the present invention is described in detail.It is important to note that specific embodiments and the drawings are only to illustrate, obvious those skilled in the art according to illustrating, can carry out various correction or change to the present invention herein, and these are revised and change and also will include within the scope of the invention.
Accompanying drawing explanation
Fig. 1 is iodine-125 contained radioactivity particle structure schematic diagram of the present invention, wherein,
1 is outer, and 2 is internal layer.
Fig. 2 is the process chart preparing described iodine-125 contained radioactivity particle in the present invention.
Detailed description of the invention
embodiment 1
As shown in Figure 1, this iodine-125 contained radioactivity particle, is made up of outer 1 and internal layer 2; Described outer 1 wrapping inner layer 2;
Described skin 1 adopts silica gel to make;
Described internal layer 2 is the mixture of silica gel and radioactivity iodine-125.
embodiment 2
As shown in Figure 2, prepare iodine-125 contained radioactivity particle, step is:
1, the production technology of iodine-125 contained radioactivity particle
(1) prescription is produced
1. [name of product]
Iodine-125 contained radioactivity particle
2. [dosage form and specification] seals particle; 3.7 ~ 222MBq (0.1 ~ 6mCi)
3. [supplementary material inventory]
Supplementary material; Medical silica-gel 1,2; Normal octane; Radioactivity iodine-125 solution;
4. [radionuclide halflife] radionuclide halflife: T1 ∕ 2=60.1 days;
5. [purposes] is for the tumor (as tumor of head and neck, pulmonary carcinoma, cancer of pancreas, benign prostatic tumor) in shallow table, splanchnocoel; If its tumor be unresectable, limitation, poky, lonizing radiation, during low or medium sensitivity, can be tried out this product and be treated; This product is also applicable to the tumor of tumor and the recurrence remained through lonizing radiation external radiotherapy;
(2) production operation
1. Workplace and device therefor
A. workshop and clean area:
The workshop that iodine-125 contained radioactivity particle need have higher requirements at ventilation, filtration and preventer carries out; Last activity measurement, sub-bottle, delivery packaging need be carried out in D level clean area, and require that temperature is 18 ~ 26 DEG C, humidity is 45% ~ 65%; Non-clean area humiture has no special requirements;
The operations such as silica gel mixing, dissolving are in general production area; The operations such as radiation preparation, wire drawing, baking complete in the seal box possessing air filter or ventilated chamber; Cleaning completes in ventilated chamber; The operations such as dose measurement, sub-bottle warehouse-in and packaging complete in D level clean area.
B. key equipment
With glove box and ventilated chamber, fiber feeder, baker, appearance inspecting system, nucleic activity meter, Liquid Scintillation Analyzer, surface contamination instrument, heated at constant temperature instrument, multi-channel energy spectrometer, slide gauge, particle measurement support, air conditioning and cleaning system, other radiation-protection equipments of air filtration and radioprotector;
2. process chart
As shown in Figure 2;
2, the making step of iodine-125 contained radioactivity particle
(1) liquid-state silicon gel 1 and silica gel 2 are got two equivalent to mix in beaker;
(2) getting appropriate normal octane adds in the mixture of above-mentioned silica gel, by three's mix homogeneously, and can pull out fine rule, make mixture A;
(3) said method is adopted to be mixed with identical mixture B again, stand-by;
(4) said mixture A and mixture B is moved in the glove box with protection of sealing and (because following operation uses with volatile iodine-125 solution, need prevent it from irradiating human body generation and producing environment and pollute);
(5) size of the iodine-125 contained radioactivity particle activity prepared as required, adds the iodine-125 solution (specific activity is greater than 800mCi/ml) of high concentration in mixture A, and again by all substances mix homogeneously;
(6) use special instrument that mixture A is pulled into diameter and be about 0.5mm fine rule, then it is dried at the temperature of 70 degree;
(7) fine rule containing iodine-125 nucleic of drying is cut into the short silk that length is about 3.3mm;
(8) the liquefied mixture B leaching above-mentioned short silk being placed in radioactivity I125 is put, and dries, make the sealing particle that inside is surrounded by iodine-125 nucleic with tweezers after pressing from both sides out under being again placed in the temperature of 70 degree;
(9) iodine-125 of above-mentioned drying sealing particle is inserted in vial, then vial is put into pig, shift out from glove box, proceed to lower road visual examination operation.
3, the outward appearance of iodine-125 contained radioactivity particle is checked
(1) the iodine-125 contained radioactivity particle shifted out from glove box, is placed in the ventilated chamber with protection, air draft, filtration, carries out the visual examination (sealing of particle described in trial inspection of particle; This inspection is carried out in the imaging system of amplifying, and clearly can observe the surface structure of particle in display bottle);
(2) particle to be seen is put into rustless steel pallet, and pallet is placed under photographic head, the coarse adjustment knob on adjustment photographic head, make the display object on display enough large, then adjust the fine tuning knob on photographic head, make display object enough clear;
(3) use tweezers slowly to stir sealing particle, make it rotation 360 °;
(4) described sealing particle is observed over the display; Result show, this particle surface should smooth, sealing atresia; Qualified particle puts into the bottle posting " qualified " label, defective particle then put into post " defective " label bottle, again prepare new iodine-125 contained radioactivity particle at glove box;
(5) above-mentioned steps (2) is repeated to (4), until check out all sealing particles produced; All qualified iodine-125 contained radioactivity particles are proceeded to lower road matting;
4, iodine-125 contained radioactivity particle is cleaned
(1) iodine-125 contained radioactivity particle qualified for visual examination is placed in the little glass cillin bottle of 6ml, every bottle is no more than 100;
(2) cillin bottle that iodine-125 contained radioactivity particle is housed is placed on the adjustable heated at constant temperature instrument of temperature; The temperature arranging heated at constant temperature instrument is 70 degree, electric power starting;
(3) the cleaning solution 1ml of special clean iodine-125 nucleic is added in each cillin bottle;
(4) with pipettor, cleanout fluid was siphoned away every 20 minutes, put into radioactive liquid waste bottle;
(5) above-mentioned steps (3) and each 3 times of step (4) is repeated; The radioactive radiation level of the solution that the measurement of last employing surface contamination analyzer is sucked out is (if it is very high to exceed background level, then suspect the particle that may have leakage, again need carry out visual examination to all particles in this bottle, find out the particle of leakage, more again clean; If it is not high to exceed background level, then can thinks not clean clean, again need clean and again measure, until the radiation level of sucking-off solution is low to moderate background);
(6) above-mentioned all sub-bottle splendid attires are cleaned qualified iodine-125 contained radioactivity particle, then clean three times by purified water, wash the cleanout fluid of residual special clean iodine-125 nucleic off, then proceed to lower road surface contamination and leak-testing operation;
5, check surface contamination and the leakage of iodine-125 contained radioactivity particle, with reference to GB 4076-83 sealed radioactive source general provision, method of testing is as follows:
(1) cillin bottle of iodine-125 contained radioactivity particle will be housed, add 1ml purified water and make particle submergence in every bottle, the temperature arranging heated at constant temperature instrument is 50 degree, and soak time is no less than 4 hours;
(2) with the whole liquid in suction pipe sucking-off cillin bottle, be transferred in the scintillation vial that 3 ~ 4ml scintillation solution is housed, mix homogeneously (noting not wanting the iodine-125 contained radioactivity particle in sucking-off cillin bottle);
(3) with the content of 125I in the liquid scintillation counter measurement every bottle water sample of Low background;
(4) result judges: if the content of 125I is less than 185Bq(and 5nCi in water sample), then the iodine-125 contained radioactivity particle surface in bottle does not pollute and does not leak; If in water sample, the content of 125I is equal to or greater than 185Bq(and 5nCi), iodine-125 contained radioactivity particle then in bottle should return last process and re-start visual examination and decontamination cleaning treatment, and then carries out surface contamination and leak check until all qualified or till finding out defective iodine-125 contained radioactivity particle;
(5) next procedure can be proceeded to through surface contamination and the qualified iodine-125 contained radioactivity particle of leak test;
6, the equivalent activity activity of iodine-125 contained radioactivity particle is measured
(1) standard source of iodine-125 contained radioactivity particle measurement nucleic activity meter is demarcated
1. before or after measuring iodine-125 contained radioactivity corpuscular radiation activity, all must demarcate nucleic activity meter with iodine-125 contained radioactivity particles levels source, ensure the accuracy measuring activity;
2. press nucleic activity meter indicates aim at the measurement key that iodine-125 contained radioactivity particle carries out measuring;
3. special particle measurement support is put in iodine-125 contained radioactivity particles levels source, then put into the ionization chamber of nucleic activity meter, after waiting for for 20 ~ 30 seconds, reading.
4. record iodine [125I] the sealed seed source standard source radioactivity recorded, measured value and the theoretical value calculated are made comparisons, both errors must within ± 5%;
(2) iodine-125 contained radioactivity particle is measured by equivalent activity activity during activity size sub-bottle splendid attire
1. the alignment time is set on request;
2. pick up with tweezers the special measurement bracket that a particle puts into iodine-125 contained radioactivity particle gently;
3. the measurement bracket that particle is housed is put into the ionization chamber of nucleic activity meter, the current equivalent activity activity recorded etc. record after stable reading or printing and the equivalent activity activity when the alignment time, put into the cillin bottle of corresponding equivalent activity range-of-motion by iodine-125 contained radioactivity particle;
4. step is repeated 2. extremely 3. until measure end;
(3) equivalent activity activity when user prepares iodine-125 contained radioactivity particle is measured as
1. according to equivalent activity activity and the alignment time of user's requirement, the particle in selected roughly satisfactory cillin bottle;
2. pick up with tweezers the special measurement bracket that a particle puts into iodine-125 contained radioactivity particle gently; The measurement bracket that particle is housed is put into the ionization chamber of nucleic activity meter, the current equivalent activity activity recorded etc. record after stable reading or printing and the equivalent activity activity when the alignment time, iodine-125 contained radioactivity particle is put into the cillin bottle of corresponding equivalent activity range-of-motion, measure the activity in each seed source;
3. press the sign time on label, the equivalent activity activity of simple grain sealed seed source should be and indicates 95.0 ~ 105.0% of activity; If within this equivalent radioactivity scope, then put into wrapping cillin bottle or other suitable vessels; If not within the scope of this, then return in original bottle;
2. and 3. 4. step is repeated, until pick out the iodine-125 contained radioactivity particle of user's Order Quantity;
4. protocol or print data are preserved;
(4) statistics and analysis iodine-125 contained radioactivity particle experimental data
1. adopt two kinds of different process to produce iodine-125 contained radioactivity particle, the radioactivity iodine-125 solution total amount of input is all 20mCi, and is normalized on the same day, shown in the data obtained table 1 by final activity correction:
Table 1
2. data analysis: the activity data of the iodine-125 contained radioactivity particle that above-mentioned employing two kinds of different process are produced show:
A., when dropping into radioactivity iodine-125 solution total amount and being identical, the utilization rate adopting filamentary silver and titanium pipe to produce old technique nucleic is:
12031÷24000×100%=50.1%
And adopt the utilization rate of silica gel production new technique nucleic to be:
21878÷24000×100%=91.2%
Result shows, radioactivity iodine-125 solution is after employing silica gel production technology, and utilization rate is greatly improved (reason is that the self-shileding effect of filamentary silver and titanium pipe is large);
If target activity when b. producing is 600 μ Ci, then the range-of-motion of on this basis ± 10% is 540-660 μ Ci, can find from table 1, has 8 when ading up to 20 granule within the scope of this, and ratio is 40%; Then suppose that target activity when producing is 1200 μ Ci for silica gel production technology, its range-of-motion of on this basis ± 10% is 1080-1320 μ Ci, can find from table 1, has 9 when ading up to 20 granule within the scope of this, and ratio is 45%; Result shows, adopts the quantity in the target zone of silica gel technique many, is convenient to meet number of users and activity requirement when making really to go into operation;
C. owing to have employed new technology, the noble metal of the import such as filamentary silver, titanium pipe can not therefore be used, the cost-saving and energy; Especially when producing the iodine-125 contained radioactivity particle of same activity, the iodine-125 solution of input can save nearly one times, reduces the cost and reduces environmental radiation and pollution;
7, applied code
(1) iodine-125 radioactive solution
[character] this product is colourless clear liquid;
It is appropriate that [discriminating] gets this product, and measure according to gamma ray spectrometer method (Pharmacopoeia of People's Republic of China version annex Ⅹ III in 2010), the energy of its primary photon is 35.5KeV, 31.4KeV and 27.4KeV;
It is appropriate that [radionuclide purity] gets this product, measures according to gamma ray spectrometer method (Pharmacopoeia of People's Republic of China version annex Ⅹ III in 2010);
125i content is not less than 99.9%,
126i content should lower than 0.01%; Separately get this product appropriate, detect with liquid scintillation counter, this product should not launch α, Beta-ray radionuclidic impurities containing other;
[radioactive concentration] gets this product, and measure according to radioactive concentration measurement method (Chinese people the Republic of China and state's pharmacopeia version annex Ⅹ III in 2010), the radioactivity of every 1ml should be not less than 29600MBq;
(2) medical silica-gel
[outward appearance] white clear liquid, colorless and odorless;
[performance] meets the medical silica-gel standard that country uses about human body;
(3) this product is radioactive sealed source, and involucrum is medical silica-gel material, and source core is containing the homogeneous mixture of radionuclide iodo-125 with silica gel;
[appearance character] gets this product, and by amplification imaging systems inspection, this product should seal atresia;
[size] gets this product, and detect with slide gauge or other suitable instruments, the length of this product is within the scope of 4.5 ± 0.5mm, and external diameter is 0.8 ± 0.05mm;
[nuclide identification] gets this product, according to method inspection under [radionuclide purity] item,
125the Characteristic gamma photon energy of I nucleic is 27.4KeV, 31.4KeV, 35.5KeV;
[radionuclide purity] gets this product 1, gets its source core, soaks 15 minutes (if necessary, can be ultrasonic 10 minutes), get suitable quantity of water solution and make sample, measure according to gamma ray spectrometer method (Pharmacopoeia of People's Republic of China version annex Ⅹ III in 2010) in water;
125i content should be not less than 99.9%,
126i impurity content must not cross 0.01%; Separately get above-mentioned aqueous solution appropriate, with liquid flashing counting determining, α, Beta-ray radionuclidic impurities should not be launched containing other;
[surface contamination and leak test] gets this product, is sub-packed in cillin bottle, adding distil water 1.0 ~ 1.5ml by every bottle no more than 100, soaks and is no less than 4 hours, take out water sample in bottle respectively, detect in water with liquid scintillation counter at 50 DEG C ± 5 DEG C Celsius
125the radioactivity of I, the radioactivity in every bottle of water must not more than 0.185KBq;
[equivalent activity activity] gets this product, counts instrument by the nucleic activity of being demarcated by iodine-125 contained radioactivity particles levels source, and measures under the same terms demarcated with standard source, the equivalent activity activity in every seed source.By the sign time, should be and indicate 95.0 ~ 105.0% of activity;
[specification] 3.7 ~ 222MBq(0.1 ~ 6.0mCi)
[packaging and storage] this product inner packing is 5 milliliters of vials, is equipped with Pastic screw top.Outer package is plumbous safety can processed (or having the rustless steel safety can of equal protection effect); Outer package should meet the requirement of the packaging of " GB11806-89 " I, and the greatest irradiation level of surperficial any point must not be greater than 0.5mR/h.Vial and the outer label of plumbous safety can processed;
This product should under the condition meeting radioactive substance storage, room temperature preservation;
The transport of [transport] this product is carried out according to China and international relevant regulations, and use the carton meeting commodity inspection standard, carton external application has package grade mark and ionizing radiation mark; The following files sends to user with package: product description, quality inspection testimonial, product related data and other required files;
[effect duration] tentative 6 months;
(4) material balance
1. iodine [
125i] change sodium solution utilization rate:
Utilization rate %=(adding iodine-125 activity in iodine-125 total activity-residue)/add iodine-125 total activity × 100%
The utilization rate of radioactivity iodine-125 solution is not less than 95%;
2. shelf appeal: under the condition meeting radioactive substance storage, room temperature preservation;
8, packaging operation
(1) packaged form: iodine-125 contained radioactivity particle is contained in be had in the 5ml vial of lid, label on bottle, and content comprises: specification, total activity, calibration date, seed source quantity, model and sale numbering; Vial is contained in the sealed lead safety can of similar tags;
(2) packaging material: vial and lead protection tank;
(3) operating procedure
1. order reception
Accepted the purchasing order information of client by phone, Email or fax mode, determine the quantity of iodine-125 contained radioactivity particle needed for client, equivalent activity activity, calibrate the date, require arrival date, customer information etc.;
2. dosage measurement
The equivalent radioactivity of sealed seed source required when ordering according to user, quantity and calibration date, choose the qualified finished product of dimension, the equivalent activity activity of each sealed seed source is measured with the activity meter verified through standard source, pick out the sealed seed source meeting user and require, provide reading report; By the sign time, should be and indicate 95.0 ~ 105.0% of activity.
3. pack
The particle met the requirements of the customers picked out is poured in the cillin bottle of 2% glutaraldehyde being placed with 1ml in advance and soak 20-30 minute, further clean, dry; The seed source of the drying prior ultrasound wave of immigration and water are cleaned and dry again in the cillin bottle of ultraviolet process, tighten bottle cap, post label, put into through ethanol and ultraviolet process pig or there is the rustless steel safety can outer package of equal protection effect, outer package is sticked the label of band ionization irradiation signatures;
4. transport
Meet the grade packaged requirement of " GB11806-89 " I through outsourcing wiping, the inspection of packed and transported grade, the package that namely the greatest irradiation level of surperficial any point must not be greater than 0.5mR/h is transported to user by China and international relevant regulations;
9, points for attention
(1) instrument and supplies palpus empirical tests, to guarantee the safe and effective of product;
(2) rational deployment, takes positive effective measures preventing pollution and mistake;
(3) the strict purification condition controlling purifying area, guarantees that all technical of purifying area conforms with the regulations;
(4) workman can be on duty after having to pass through training;
(5) strictly press post operation code to produce;
(6) production equipment is forbidden overtemperature, superpressure, over loading and is operated with failure;
(7) staff enters restricted area, observe the safety management code of radioactivity restricted area;
(8) according to work post needs, supply the labor protection product such as each post person works's clothing, cap, footwear, glove, mask, and be equipped with corresponding protective equipment;
(9) operation room epidemic disaster is suitable for, and ventilation installation is good.
Claims (5)
1. an iodine-125 contained radioactivity particle, is characterized in that, is made up of, this skin (1) wrapping inner layer (2) outer (1) and internal layer (2);
Described skin (1) adopts silica gel to make;
The mixture that described internal layer (2) is silica gel and radioactivity iodine-125.
2. the preparation method of iodine-125 contained radioactivity particle described in claim 1, is characterized in that, the steps include:
(1) liquid-state silicon gel 1 and silica gel 2 are got two equivalent to mix in beaker;
(2) getting appropriate normal octane adds in the mixture of above-mentioned silica gel, by three's mix homogeneously, and can pull out fine rule, make mixture A;
(3) identical mixture B is prepared again by above-mentioned same method, stand-by;
(4) said mixture A and mixture B is moved in the glove box with protection of sealing;
(5) size of the iodine-125 contained radioactivity particle activity prepared as required, adds the iodine-125 solution of high concentration in mixture A, and again by all substances mix homogeneously;
(6) mixture A is pulled into fine rule, then it is dried at the temperature of 70 degree;
(7) fine rule containing iodine-125 nucleic of drying is cut into short silk;
(8) the liquefied mixture B leaching above-mentioned short silk being placed in radioactivity I125 is put, and dries, make the sealing particle that inside is surrounded by iodine-125 nucleic with tweezers after pressing from both sides out under being again placed in the temperature of 70 degree.
3., by preparation method according to claim 2, it is characterized in that, in described step (5), the specific activity of iodine-125 solution is greater than 800mCi/ml.
4., by preparation method according to claim 2, it is characterized in that, in described step (6), the diameter that mixture A pulls into fine rule is 0.5mm.
5., by preparation method according to claim 2, it is characterized in that, in described step (7), the length of short silk is 3.3mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310372700.9A CN104415379A (en) | 2013-08-25 | 2013-08-25 | Iodine-125 sealed radioactive particle and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310372700.9A CN104415379A (en) | 2013-08-25 | 2013-08-25 | Iodine-125 sealed radioactive particle and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104415379A true CN104415379A (en) | 2015-03-18 |
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ID=52966198
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310372700.9A Pending CN104415379A (en) | 2013-08-25 | 2013-08-25 | Iodine-125 sealed radioactive particle and preparation method thereof |
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| Country | Link |
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| CN (1) | CN104415379A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111249629A (en) * | 2020-01-19 | 2020-06-09 | 闫鹏 | Carried in mouth125Radioactive particle conformal pressed film and its preparation method |
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2013
- 2013-08-25 CN CN201310372700.9A patent/CN104415379A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111249629A (en) * | 2020-01-19 | 2020-06-09 | 闫鹏 | Carried in mouth125Radioactive particle conformal pressed film and its preparation method |
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