CN104394900A - Pressure-based leak detection in extracorporeal blood treatment apparatus - Google Patents
Pressure-based leak detection in extracorporeal blood treatment apparatus Download PDFInfo
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- CN104394900A CN104394900A CN201380028623.3A CN201380028623A CN104394900A CN 104394900 A CN104394900 A CN 104394900A CN 201380028623 A CN201380028623 A CN 201380028623A CN 104394900 A CN104394900 A CN 104394900A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3413—Diafiltration
- A61M1/3417—Diafiltration using distinct filters for dialysis and ultra-filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/15—Detection of leaks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3358—Measuring barometric pressure, e.g. for compensation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
- A61M2205/505—Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
Abstract
The extracorporeal blood treatment apparatus described herein include components configured to detect liquid leaking from one or more liquid circuits in the extracorporeal blood treatment apparatus and methods of detecting liquid leaks in extracorporeal blood treatment apparatus. The components used to detect leaks include one or more remote pressure ports connected to one or more local pressure ports on one or more pressure sensors by one or more fluid-filled pressure lines. The fluid in the pressure lines transmits pressure exerted on a remote pressure port by any collected liquid to the local pressure port of the pressure sensor.
Description
Intersection is quoted
This application claims the U.S. Provisional Application the 61/747th of December in 2012 submission on the 31st, the rights and interests of No. 718, its disclosure is combined in this by quoting.
Technical field
Extracorporeal blood treatment and the using method thereof of the parts be combined with for carrying out Leak Detection based on pressure are described herein.
Background technology
Extracorporeal blood treatment comprises and obtains blood from patient, in the outer processing blood of patient body, and the blood after process is returned to patient.Extracorporeal blood treatment is normally used for extracting unwanted material or molecule from the blood of patient, and/or benefit materials or molecule is added in blood.Extracorporeal blood treatment is used for the patient that effectively can not remove material from their blood, such as, when suffering from the patient of interim or permanent renal failure.Such as, these and other patient can stand extracorporeal blood treatment with to they blood substance or remove material from their blood, thus keep acid-base balance or remove surplus fluid.
Usually, by the blood of the patient that samples in the mode of Continuous Flow, and by being incorporated into by blood in the blood chamber of the filter limited by semipermeable membrane at least in part, perform extracorporeal blood treatment.According to the type of process, semipermeable membrane can optionally allow the unwanted material comprised in blood to pass this film to compensated cavity from blood chamber, and the benefit materials that can optionally allow to be included in the liquid entered in compensated cavity passes this film in the blood entered in blood chamber.
Some extracorporeal blood treatment can perform with identical machine.In ultrafiltration (UF) process, unwanted material is removed through film by convection current in compensated cavity from blood.
In blood filtration (HF) process, as in UF, blood flows through the chamber limited by semipermeable membrane at least in part, and before or after blood passes filter and before it turns back to patient, usually by fluid is incorporated in blood, benefit materials is added in blood.
In hemodialysis (HD) process, the auxiliary fluid containing benefit materials is incorporated in the compensated cavity of filter.Unwanted material in blood is by diffusing through semipermeable membrane and penetrating in auxiliary fluid, and the benefit materials of auxiliary fluid can pass film and penetrate in blood.
In hemodiafiltration (HDF) process, as in HD, blood and their material of auxiliary fluid exchange, and further, as in HF, fluid is incorporated in the blood after process typically via before turning back to patient, material is added in blood; Unwanted material is removed from blood by convection current and diffusion.
In those process using auxiliary fluid, auxiliary fluid is by the compensated cavity of filter and receive by diffusion and/or convection current through the unwanted material in the blood of film.Then, from this wave filter, draw this liquid: it is commonly called waste liquid, and be sent to discharging tube, or be sent to container and be then discharged into drain pipe.
Extracorporeal blood treatment for realizing these treatments generally includes many parts, as: pump, valve, pipe, sensor, they are connected to each other to be formed multiple fluid loop.In the process of operative installations, the less desirable leak of liquid of one or more fluid loop may occur in the one or more abutments between various parts, or produces due to one or more parts damages or fault.
Although the fluid loop in vitro in blood processor is designed to play a role under all operations condition and do not leak, in some cases, the one or more fluid loops in extracorporeal blood treatment may leak potentially.Except the less desirable loss causing material, the leakage possibility damage device of fluid loop in extracorporeal blood treatment, and the treatment of patient may be jeopardized.
Summary of the invention
Extracorporeal blood treatment as herein described comprises the parts being configured to detect the liquid leaked from one or more fluid loops of extracorporeal blood treatment, and the method for the leak of liquid of detection extracorporeal blood treatment.Parts for detecting leakage comprise the remote pressure port being connected to the local pressure port on pressure transducer by the pressure piping of fluid filled.Liquid by any collection pressure be applied on remote pressure port is delivered to the local pressure port of pressure transducer by the fluid in pressure piping.
In one or more embodiments, by the pressure piping of fluid filled, remote pressure port is separated authorized pressure sensor electrical with pressure transducer and is connected to control unit, and extend to the remote pressure port collecting leakage liquid place without the need to electrical connection.On the contrary, the pressure on remote pressure port is sent to pressure transducer local pressure port by the pressure piping of fluid filled is applied to.
In one or more embodiments, pressure transducer equally with control unit can be arranged in housing, and the pressure piping of this fluid filled extends the liquid header residing for housing to this remote pressure port.The electrical connection of the shortening between pressure transducer and control unit can be favourable, because the longer electrical connection extending to control unit from remote pressure port can cause electrical interference (especially the extracorporeal blood treatment of the position of collecting leakage liquid away from the housing of this device) potentially.Such as, leakage liquid can detect at the pedestal of device, and housing is positioned at the distance of above pedestal such as more than a meter simultaneously.
In one or more embodiments, extracorporeal blood treatment as herein described can comprise the single remote pressure port being connected to the local pressure port of pressure transducer by the pressure piping of wall scroll fluid filled.In one or more alternate embodiment, extracorporeal blood treatment as herein described can comprise two or more remote pressure ports of two or more the local pressure port being connected to one or more pressure transducer, and wherein each remote pressure port is connected to its respective local pressure port by the pressure piping of special fluid filled.In such embodiments, remote pressure port can be arranged to the pressure reduction between detection two remote pressure ports, and uses this pressure reduction as the basis judging to have occurred in extracorporeal blood treatment to leak.
Although herein be configured to use dialysis solution to perform the extracorporeal blood treatment of dialysing and be described relatively, in any extracorporeal blood treatment, also may run into Similar Problems.In order to the object discussed herein, leak detecting device can be incorporated into any extracorporeal blood treatment, such as, use be used for renal function the displacement liquid of convection current replacement therapy, the blood plasma of being used for the treatment of property plasmapheresis (TPE), albumin or colloid solution or any other known type that use relevant to extracorporeal blood treatment the extracorporeal blood treatment of medical fluid.
In one aspect, one or more embodiments of extracorporeal blood treatment as herein described comprise: housing, fluid loop, is arranged on described housing or described housing, and wherein, described fluid loop comprises and is configured to be moved by blood by described fluid loop to carry out one or more pump and the pipeline of extracorporeal blood treatment, liquid header, is configured to collect the liquid leaked from described fluid loop, wherein, the described liquid leaked from described fluid loop arrives described liquid header under gravity, and pressure transducer, comprise and be arranged on described housing or the local pressure port of described housing, be arranged in the remote pressure port at the select location place of described liquid header and extend to the pressure piping of described local pressure port from described remote pressure port, the fluid accumulation that described catcher is collected is above described select location, wherein, described local pressure port is positioned in described liquid header, remote pressure port described in the liquid comes into contact that described in described liquid header select location place is collected, and wherein, described pressure piping is configured to the pressure be applied on described remote pressure port to be delivered to described local pressure port via the fluid being arranged in described pressure piping.This device also comprises control unit, this control unit is operably connected to described pressure transducer, and wherein, described control unit is configured to: from described pressure transducer Received signal strength, wherein, the pressure that sensed by the remote pressure port of described pressure transducer of described signal designation; And when the pressure sensed by described remote pressure port meets or exceeds selected pressure limit, make the judgement that liquid leaks from described fluid loop.
In one or more embodiments of extracorporeal blood treatment as herein described, pressure piping is connected to remote pressure port by fluid-tight adapter.
In one or more embodiments of extracorporeal blood treatment as herein described, pressure piping is connected to local pressure port by fluid-tight adapter.
In one or more embodiments of extracorporeal blood treatment as herein described, the fluid in described pressure piping is in fact by one or more gas compositions.
In one or more embodiments of extracorporeal blood treatment as herein described, the fluid in described pressure piping is made up of one or more liquid in fact.
In one or more embodiments of extracorporeal blood treatment as herein described, described pressure transducer comprises: be configured to the second remote pressure port measuring atmospheric pressure at the second select location place; And second pressure piping of the second local pressure port of pressure transducer is extended to from described second remote pressure port, wherein, described second pressure piping is configured to the pressure be applied on the second remote pressure port to be delivered to the second local pressure port by the fluid being arranged in described second pressure piping; And wherein, described control unit be configured to when the difference of the pressure that described remote pressure port and described second remote pressure port sense reach or more than a set point value time, make the judgement that liquid leaks from described fluid loop.In one or more embodiments, second select location is positioned in the selected height relative to described second local pressure port, and the remote pressure port wherein, being positioned at the described select location place of described liquid header is also positioned at the described selected height relative to connected local pressure port.In one or more embodiments, the fluid in the second pressure piping is in fact by one or more gas compositions.In one or more embodiments, the fluid in the second pressure piping is made up of one or more liquid in fact.
In one or more embodiments of extracorporeal blood treatment as herein described, described control unit is operably connected to the pump in one or more pumps of described fluid loop, and wherein, described control unit is configured to when described control unit judges that described fluid loop stops the operation of this pump when leaking.
In second aspect, can comprise in one or more embodiments of the method detecting as described herein the leakage in extracorporeal blood treatment: by being arranged on housing or the fluid loop of housing carrys out pumping liquid, described fluid loop comprises the one or more pump and pipeline that are configured to perform extracorporeal blood treatment; The liquid collecting leaked from described fluid loop is being arranged in the liquid header below described housing; Detection is applied to the pressure on the remote pressure port of pressure transducer by the liquid collected in described liquid header, wherein, described pressure transducer is arranged on described housing or described housing, and wherein, described remote pressure port is arranged in the select location of described liquid header; The pressure detected at described remote pressure port is delivered to described local pressure port by the pressure piping that use extends to the local pressure port of described pressure transducer from described remote pressure port, wherein, pressure is delivered to described local pressure port from described remote pressure port by the fluid being arranged in described pressure piping by described pressure piping; And when the pressure sensed by described remote pressure port meets or exceeds selected pressure limit, make the judgement that liquid leaks from described fluid loop.
In second aspect, can comprise in one or more embodiments of the method detecting as described herein the leakage in extracorporeal blood treatment: by being arranged on housing or the fluid loop of housing carrys out pumping liquid, described fluid loop comprises the one or more pump and pipeline that are configured to perform extracorporeal blood treatment; The liquid collecting leaked from described fluid loop is being arranged in the liquid header below described housing; Detection is applied to the pressure on the first remote pressure port by the liquid collected in described liquid header, wherein, described first remote pressure port is arranged in the first select location place of described liquid header, and the fluid accumulation wherein, collected by described catcher is above described first remote pressure port; Using to extend to from described first remote pressure port is arranged in described housing or the pressure detected at described first remote pressure port is delivered to described first ground pressure port by first pressure piping of first ground pressure port of the pressure transducer of described housing, wherein, pressure is delivered to described first ground pressure port from described first remote pressure port via the fluid being arranged in described first pressure piping by described first pressure piping; Detect the atmospheric pressure acted on the second remote pressure port; The atmospheric pressure detected at described second remote pressure port is delivered to described second local pressure port by the second pressure piping that use extends to the second local pressure port of described pressure transducer from described second remote pressure port, wherein, pressure is delivered to described second local pressure port from described second remote pressure port via the fluid being arranged in described second pressure piping by described second pressure piping; And when the difference of the pressure sensed by described first remote pressure port and described second remote pressure port meets or exceeds a set point value, make the judgement that liquid leaks from described fluid loop.In one or more embodiments, described second remote pressure port is positioned in the selected height relative to described second local pressure port, and wherein, described first remote pressure port is also positioned at the described selected height relative to described first ground pressure port.
In one or more embodiments of method described herein, the fluid in described pressure piping is in fact by one or more gas compositions.
In one or more embodiments of methods described herein, described method stops the pump in the one or more pumps in described fluid loop after being also included in and judging that liquid leaks from described fluid loop.
Unless the context clearly determines otherwise, as herein and the singulative " " used in appended claims, " one " and " being somebody's turn to do " comprise plural reference.Therefore, such as, mention " one " or " being somebody's turn to do " assembly and can comprise one or more assembly and its equivalent well known by persons skilled in the art.In addition, term "and/or" refers to one or all element listed, or two or more the combination any in listed element.
It should be noted, appearance term in the description " comprises " and modification does not have limited significance.And " one ", " one ", " being somebody's turn to do ", " at least one " and " one or more " are used interchangeably herein.
Above content is not intended to each embodiment or the often kind of implementation that describe extracorporeal blood treatment described herein and method.On the contrary, and based on the following explanation of appended accompanying drawing by reference to exemplary embodiment and claims, more complete understanding of the present invention will become apparent and be easy to understand.
Accompanying drawing explanation
Fig. 1 illustrates an exemplary embodiment of extracorporeal blood treatment, and it is configured to use and detects leakage based on the Leak Detection of pressure as described herein.
Fig. 2 is the schematic diagram of an exemplary embodiment of the extracorporeal blood treatment comprising fluid loop as described herein.
Fig. 3 is the schematic diagram of another exemplary embodiment of extracorporeal blood treatment as described herein.
Detailed description of the invention
In the following description of exemplary embodiment, with reference to the accompanying drawing forming a part herein, and show specific embodiment by way of example in the accompanying drawings.Should be understood that, other embodiment can be utilized, and structure change can be carried out without departing from the present invention.
An exemplary embodiment of extracorporeal blood treatment is shown in Fig. 1.In one or more embodiments, extracorporeal blood treatment 1 is the dialysis machine being used for the treatment of renal insufficiency, and it can perform one or more following process: hemodialysis, isolated ultrafiltration, hemofiltration, hemodiafiltration, therapeutic plasma exchange etc.
In the embodiment shown in fig. 1, device 1 is specially adapted to the intensive treatment of acute renal failure, and comprise blood processing apparatus 2 (such as, dialyser filter) and fluid (such as, blood, dialysis solution etc.) can be sent to the fluid distribution loop 3 of blood processing apparatus 2.In order to make accompanying drawing simple and clear, the supporter for fluid distribution loop 3 is only shown in Fig. 1.
Extracorporeal blood treatment 1 also comprises for the one or more pumps 4 at fluid distribution loop 3 fluid circulating.Fluid distribution loop 3 can be configured to blood to move to patient and from patient's movement blood, and the mobile fluid being provided and/or be sent to reservoir 6 by reservoir 6, in an illustrated embodiment, this reservoir 6 hangs on the bottom 13 of the housing 12 of extracorporeal blood treatment 1.Shown reservoir 6 is the form of sack, but other suitable container any for comprising fluid in inside also can be used to replace sack.
Extracorporeal blood treatment 1 shown in Fig. 1 also comprises pedestal 14, and housing 12 is supported on above this pedestal 14 by column 16.Pedestal 14 comprises liquid header 20, and it is located at below the bottom 13 of housing 12.Catcher 20 be shaped as collect among the housing 12 of the extracorporeal blood treatment 1 be positioned at above pedestal 14 or on fluid loop leak liquid.The shaping surface of catcher 20 and or be by the region of liquid collecting at catcher 20 at angle, and which position first to contact catcher 20 regardless of liquid in.In the embodiment shown in fig. 1, such as, catcher 20 comprises the surface being designed to liquid to guide towards collecting region 23, and this collecting region 23 is lower than the remainder position of catcher 20.
Can also see remote pressure port 22 from the embodiment of the extracorporeal blood treatment 1 shown in Fig. 1, as described herein, remote pressure port 22 combines with pressure transducer and uses, to detect the leakage of extracorporeal blood treatment 1.Although show two remote pressure ports 22 in the embodiment in figure 1, in other embodiment one or more, as will be described herein, the remote pressure port of can such as be used as few as to perform the leakage detection function of device described herein.
Fig. 2 is the schematic diagram of an exemplary embodiment of extracorporeal blood treatment, and it comprises fluid loop as described herein.A part of the fluid loop described comprises blood pump 4a, and this blood pump 4a is configured to the mobile blood using arterial line 7 to shift out from patient P, and such as uses blood pump 4a to send it to blood processing apparatus 2.Fluid loop shown in Fig. 2 also comprises the venous line 8 for blood to be turned back to patient P from filter 2.Another part of fluid loop shown in Fig. 2 comprises dialysis liquid pump 4b, it is for being sent to dialysis solution blood processing apparatus 2 from reservoir 6a via delivery line 9, and will shift out from blood processing apparatus 2 with the dialysis solution crossed via waste-solution line 10 and send it to reservoir 6b.
In the exemplary embodiment of the extracorporeal blood treatment of Fig. 2, catcher 20 is also shown, its enough greatly and suitably to locate to collect among extracorporeal blood treatment 1 or on the liquid that leaks of fluid loop.Preferably, catcher 20 comprises inclination or angled surface, the liquid falling into catcher 20 is sent to and is collected in remote pressure port 22 by above the position of locating.Remote pressure port 22 is connected to the local pressure port 26 on pressure transducer 28 by pressure piping 24.
The liquid be collected in catcher 20 applies pressure on remote pressure port 22, and this pressure is delivered to the local pressure port 26 on pressure transducer 28 by the pressure piping 24 of fluid filled.As discussed in this article, use the pressure piping 24 of fluid filled that the liquid pressure be applied on remote pressure port 22 collected in catcher 20 is delivered to local pressure port 26 on pressure transducer 28, can reduce or eliminate the potential of electrical Interference that the electrical connection that extends on the path that the pressure piping 24 with fluid filled is identical can cause like this may.
In one or more embodiments, remote pressure port 22 can comprise film or other structure, thus prevents the liquid be collected in catcher 20 from entering remote pressure port 22 in the mode of the pressure piping 24 allowing it to be mixed into or enter fluid filled.
In one or more embodiments of extracorporeal blood treatment as herein described, pressure piping 24 for fluid filled pressure being delivered to the local pressure port 26 of pressure transducer 28 from remote pressure port 22 can be connected to remote pressure port 22 via adapter 23, and is connected to the local pressure port 26 on pressure transducer 28 via adapter 27.Adapter 23 and 27 can be identical or different, and can various forms be taked, such as, other suitable connection any of the fluid between the liquid that Rule rotation lock connects, bayonet type is installed, hose clip and joint or the fluid in pressure piping 24 and remote pressure port 22 place leak and in pressure piping 24 and pressure needed for transmitting between local pressure port 26.
In one or more embodiments of extracorporeal blood treatment as herein described, the fluid in pressure piping 24 can be can with acceptable precision by the pressure transmission that is applied on the remote pressure port 22 any suitable fluid to the local pressure port 26 on pressure transducer 28.The example of some potential suitable fluids used in the pressure piping 24 of fluid filled can comprise such as air, nitrogen, saline solution, gel, water etc.In one or more embodiments, the pressure piping of the fluid filled used in extracorporeal blood treatment described herein can only blanketing gas be (such as, fluid essence in pressure piping is made up of one or more gases, as air, nitrogen etc.), or they only can be filled with liquid (fluid such as, in pressure piping can be made up of one or more liquid in fact).
Another parts described relatively with the exemplary embodiment of the extracorporeal blood treatment 1 in Fig. 2 are control units 30.In the embodiments described, blood pump 4a and dialysis solution pump 4b is operably connected to control unit 30.In addition, the pressure transducer 28 being connected to remote pressure port 22 by the pressure piping 24 of fluid filled is also operably connected to control unit 30.
Control unit 30 is configured to from pressure transducer 28 Received signal strength.The pressure that remote pressure port 22 place of the local pressure port 26 be connected on pressure transducer 28 at the pressure piping 24 by fluid filled from the signal designation of pressure transducer 28 senses.If the pressure sensed from the signal designation remote pressure port 22 that pressure transducer 28 receives by control unit 30 exceeds the selected limit, then can judge that liquid leaks from the fluid loop extracorporeal blood treatment 1.
The selected limit can be the function of the amount of liquid in catcher 20, and this amount of liquid is relevant to the liquid height in the catcher 20 above remote pressure port 22.Particularly, the function of the pressure (P) at remote pressure port 22 place is P=ρ * g*h, the wherein density of ρ=liquid, g=acceleration of gravity, and the height of h=remote pressure port 22 upper liquid.
If made this judgement, then extracorporeal blood treatment 1 can be configured to report to the police or the form of other signal provides instruction to operator, and the operation of the one or more pumps being operably connected to control unit in one or more embodiments, can also be caused to stop.In addition, if extracorporeal blood treatment comprises the valve, clip etc. that can optionally close, then also can cause closed (if such action is necessary) of control unit starter gate valve, clip etc. for the judgement occurring to leak in extracorporeal blood treatment.
The control unit used in extracorporeal blood treatment described herein can be arranged in any suitable form, and can such as comprise memorizer and controller.This controller can be such as the form such as one or more microprocessor, special IC (ASIC) state machine.Control unit can comprise one or more any suitable input equipment being configured to allow user operation device (such as, keyboard, touch screen, mouse, trace ball etc.), and be configured to communicating information to the display device of user (such as, watch-dog (it can be may not be touch screen), display lamp etc.).
Another alternative exemplary embodiment of extracorporeal blood treatment 101 is shown in Figure 3.Have pump 104, pressure transducer 128 and control unit 130 in the parts of a part for formation extracorporeal blood treatment 101 shown in the schematic shown in figure 3, all these parts are all described to the housing 112 being positioned at extracorporeal blood treatment 101.Extracorporeal blood treatment 101 shown in Fig. 3 also comprises liquid header 120, and this liquid header 120 is located and size is made as the liquid collected and leak from the fluid loop in extracorporeal blood treatment 101.
Pressure transducer 128 comprises two local pressure port 126a and 126b.First remote pressure port one 22a is connected to the local pressure port 126a on pressure transducer 128 by the pressure piping 124a of fluid filled, and the second remote pressure port one 22b is connected to the local pressure port 126b of pressure transducer 128 by the pressure piping 124b that second fluid is filled.
First remote pressure port one 22a is positioned in liquid header 122 and is applied to pressure on remote pressure port one 22a to detect by the liquid collected in liquid header 120.Second remote pressure port one 22b is open for atmospheric pressure.In one or more embodiments, the second remote pressure port one 26b is positioned on the height h identical with the first remote pressure port one 22a relative to local pressure port 126a and 126b.Do permission system like this and both corrected atmospheric pressure change, eliminate again the pressure head produced by the fluid in pipeline 124a and 124b of fluid filled.It should be pointed out that relative positional terms used herein, such as " top ", " below " and " highly " record along the direction of gravity.
Although local pressure port 126a and 126b is a part for single pressure sensor 128 in the embodiments described, but in one or more alternate embodiment, each local pressure port can be connected to separately and independently pressure transducer, and wherein each independently pressure transducer is operably connected to control unit 130.
Although describe the method for the leakage detected in extracorporeal blood treatment relatively with the device shown in Fig. 1-Fig. 3, one or more embodiments of the method for the leakage in detection extracorporeal blood treatment described herein can comprise on the housing by being arranged in extracorporeal blood treatment or be positioned at the fluid loop pumping liquid of housing of extracorporeal blood treatment.As described herein, this fluid loop can comprise the one or more pump and pipeline that are configured to perform extracorporeal blood treatment.The liquid header below the housing being arranged in extracorporeal blood treatment can be collected in from the liquid of fluid loop leakage.
In one or more embodiments, these methods can comprise the pressure detecting and to be applied to by the liquid be collected in liquid header on the remote pressure port of pressure transducer.This pressure transducer is arranged on housing or housing, and remote pressure port is arranged in the select location of liquid header.Being applied to pressure on remote pressure port uses the pressure piping extending to local pressure port from remote pressure port to be passed to the local pressure port of pressure transducer.Pressure is delivered to local pressure port from remote pressure port by being arranged in the fluid of pressure piping by pressure piping.
When being collected in the pressure be applied on remote pressure port of the liquid in leakage interception vessel and meeting or exceeding selected pressure limit, the method comprises judgement liquid further and leaks out from fluid loop.
Detecting in one or more alternate embodiments of the method for leaking as described in this article, detecting and can comprise by the leakage liquid institute applied pressure be collected in liquid header the pressure detecting and to be applied to by the liquid collected in liquid header on the first remote pressure port of pressure transducer.On the housing that pressure transducer is arranged in extracorporeal blood treatment or the housing of extracorporeal blood treatment.First remote pressure port is arranged in the first select location of liquid header.The pressure that detects in the first remote pressure port uses the first pressure piping extending to first ground pressure port from the first remote pressure port to be sent to the first ground pressure port of pressure transducer.Pressure is sent to first ground pressure port from the first remote pressure port by being arranged in the fluid of the first pressure piping by the first pressure piping.
The method can also comprise the atmospheric pressure detecting and be applied on the second remote pressure port, and this second remote pressure port is connected to the second local pressure port of pressure transducer by the pipeline that second fluid is filled.As a result, the pressure be applied on the first remote pressure sensor can be adjusted to considers atmospheric change.In one or more embodiments, the second remote pressure port can be positioned in the height identical with the first pressure port relative to the local pressure port on pressure transducer.As a result, the pressure be applied on the first remote pressure port also can adjust for pressure head, and this pressure head produces due to the fluid be connected to by the first and second remote pressure ports in the pressure piping of the fluid filled of pressure transducer.
The method relating to the pressure detecting on the first and second such remote pressure ports comprises: when the difference of the pressure that the first remote pressure port and the second remote pressure port sense reach or more than a set point value time, judge that liquid leaks from fluid loop.
Detecting as described in this article in one or more embodiments of method of the leakage in the fluid loop of extracorporeal blood treatment, for the fluid in from remote pressure port to the pressure piping of local port pressure transmission of pressure in fact by one or more gas compositions.
Detecting in one or more embodiments of method of the leakage in the fluid loop of extracorporeal blood treatment as described in this article, be made up of one or more liquid in fact for the fluid in from remote pressure port to the pressure piping of local pressure port transmission of pressure.
Detecting in one or more embodiments of method of the leakage in the fluid loop of extracorporeal blood treatment as described in this article, the method can comprise: when judging that liquid leaks from fluid loop, the pump in the one or more pumps in stop liquid loop.
The entire disclosure of the patent pointed out herein, patent documentation and publication all by reference entirety is incorporated to, as each in them is incorporated to herein respectively.
To blood processor and use its illustrative examples of method to discuss, and with reference to possible change.These and other change in the present invention and to be modified in will be apparent without departing from the scope of the invention to those skilled in the art, and should be appreciated that the present invention is not limited to exemplary embodiment described in this paper.Therefore, the present invention is only limited by following claims of providing and equivalent thereof.
Claims (15)
1. an extracorporeal blood treatment, comprising:
Housing;
Fluid loop, is arranged on described housing or described housing, and wherein, described fluid loop comprises and is configured to be moved by blood by described fluid loop to carry out one or more pump and the pipeline of extracorporeal blood treatment;
Liquid header, is configured to collect the liquid leaked from described fluid loop; Wherein, the described liquid leaked from described fluid loop arrives described liquid header under gravity;
Pressure transducer, comprise and be arranged on described housing or the local pressure port of described housing, be arranged in the remote pressure port at the select location place of described liquid header and extend to the pressure piping of described local pressure port from described remote pressure port, the fluid accumulation that described catcher is collected is above described select location, wherein, described local pressure port is positioned in described liquid header, remote pressure port described in the liquid comes into contact that described in described liquid header select location place is collected, and wherein, described pressure piping is configured to the pressure be applied on described remote pressure port to be delivered to described local pressure port via the fluid being arranged in described pressure piping, and
Control unit, is operably connected to described pressure transducer, and wherein, described control unit is configured to:
From described pressure transducer Received signal strength, wherein, the pressure that sensed by the remote pressure port of described pressure transducer of described signal designation; And
When the pressure sensed by described remote pressure port meets or exceeds selected pressure limit, make the judgement that liquid leaks from described fluid loop.
2. device according to claim 1, wherein, described pressure piping is connected to described remote pressure port by fluid-tight adapter.
3. device according to claim 1 and 2, wherein, described pressure piping is connected to described local pressure port by fluid-tight adapter.
4. device according to any one of claim 1 to 3, wherein, the fluid in described pressure piping is in fact by one or more gas compositions.
5. device according to any one of claim 1 to 3, wherein, the fluid in described pressure piping is made up of one or more liquid in fact.
6. device according to any one of claim 1 to 5, wherein, described pressure transducer comprises:
Second remote pressure port, is configured to measure atmospheric pressure at the second select location place; And
Second pressure piping, the second local pressure port of described pressure transducer is extended to from described second remote pressure port, wherein, described second pressure piping is configured to the pressure be applied on described second remote pressure port to be delivered to described second local pressure port by the fluid being arranged in described second pressure piping;
And wherein, described control unit be configured to when the difference of the pressure that described remote pressure port and described second remote pressure port sense reach or more than a set point value time, make the judgement that liquid leaks from described fluid loop.
7. device according to claim 6, wherein, described second select location is positioned in the selected height relative to described second local pressure port, and the remote pressure port wherein, being arranged in the select location place of described liquid header is also positioned at described selected height relative to connected described local pressure port.
8. the device according to any one of claim 6 to 7, wherein, the fluid in described second pressure piping is in fact by one or more gas compositions.
9. the device according to any one of claim 6 to 7, wherein, the fluid in described second pressure piping is made up of one or more liquid in fact.
10. device according to any one of claim 1 to 9, wherein, described control unit is operably connected to the pump in one or more pumps of described fluid loop, and wherein, described control unit is configured to when described control unit judges that described fluid loop stops the operation of this pump when leaking.
11. 1 kinds of methods detecting the leakage in extracorporeal blood treatment, described method comprises:
By being arranged on housing or the fluid loop of housing carrys out pumping liquid, described fluid loop comprises the one or more pump and pipeline that are configured to perform extracorporeal blood treatment;
The liquid collecting leaked from described fluid loop is being arranged in the liquid header below described housing;
Detection is applied to the pressure on the remote pressure port of pressure transducer by the liquid be collected in described liquid header, wherein, described pressure transducer is arranged on described housing or described housing, and wherein, described remote pressure port is arranged in the select location of described liquid header;
Use the pressure piping that extends to the local pressure port of described pressure transducer from described remote pressure port by described remote pressure Port detecting to pressure be delivered to described local pressure port, wherein, pressure is delivered to described local pressure port from described remote pressure port via the fluid being arranged in described pressure piping by described pressure piping; And
When the pressure sensed by described remote pressure port meets or exceeds selected pressure limit, make the judgement that liquid leaks from described fluid loop.
12. 1 kinds of methods detecting the leakage in extracorporeal blood treatment, described method comprises:
By being arranged on housing or the fluid loop of housing carrys out pumping liquid, described fluid loop comprises the one or more pump and pipeline that are configured to perform extracorporeal blood treatment;
The liquid collecting leaked from described fluid loop is being arranged in the liquid header below described housing;
Detection is applied to the pressure on the first remote pressure port by the liquid be collected in described liquid header, wherein, described first remote pressure port is arranged in the first select location place of described liquid header, and the fluid accumulation wherein, collected by described catcher is above described first remote pressure port;
Use from described first remote pressure port extend to be arranged in described housing or the pressure transducer of described housing first ground pressure port the first pressure piping by described first remote pressure Port detecting to pressure be delivered to described first ground pressure port, wherein, described pressure is delivered to described first ground pressure port from described first remote pressure port via the fluid being arranged in described first pressure piping by described first pressure piping;
Detect the atmospheric pressure acted on the second remote pressure port;
Use the second pressure piping of extending to the second local pressure port of described pressure transducer from described second remote pressure port by described second remote pressure Port detecting to atmospheric pressure be delivered to described second local pressure port, wherein, pressure is delivered to described second local pressure port from described second remote pressure port via the fluid being arranged in described second pressure piping by described second pressure piping; And
When the difference of the pressure sensed by described first remote pressure port and described second remote pressure port meets or exceeds a set point value, make the judgement that liquid leaks from described fluid loop.
13. methods according to claim 12, described second remote pressure port is positioned in the selected height relative to described second local pressure port, and wherein, described first remote pressure port is also at the described selected height relative to described first ground pressure port.
14. according to claim 11 to the method according to any one of 13, and wherein, the fluid in pressure piping is in fact by one or more gas compositions.
15. according to claim 11 to the method according to any one of 14, and wherein, described method stops the pump in the one or more pumps in described fluid loop after being also included in and judging that liquid leaks from described fluid loop.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261747718P | 2012-12-31 | 2012-12-31 | |
| US61/747,718 | 2012-12-31 | ||
| PCT/US2013/077928 WO2014106010A1 (en) | 2012-12-31 | 2013-12-27 | Pressure-based leak detection in extracorporeal blood treatment apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104394900A true CN104394900A (en) | 2015-03-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380028623.3A Pending CN104394900A (en) | 2012-12-31 | 2013-12-27 | Pressure-based leak detection in extracorporeal blood treatment apparatus |
Country Status (2)
| Country | Link |
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| CN (1) | CN104394900A (en) |
| WO (1) | WO2014106010A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113384767A (en) * | 2021-06-08 | 2021-09-14 | 汕头大学医学院第一附属医院 | Portable blood purification device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9861733B2 (en) | 2012-03-23 | 2018-01-09 | Nxstage Medical Inc. | Peritoneal dialysis systems, devices, and methods |
| EP3542840B1 (en) | 2011-03-23 | 2023-04-26 | NxStage Medical, Inc. | Peritoneal dialysis systems |
| WO2019169081A2 (en) | 2018-02-28 | 2019-09-06 | Nxstage Medical, Inc. | Fluid preparation and treatment devices, methods, and systems |
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| WO1993002340A1 (en) * | 1991-07-25 | 1993-02-04 | The Whitaker Corporation | Liquid level sensor |
| WO1996025214A1 (en) * | 1995-02-13 | 1996-08-22 | Aksys, Ltd. | Modular home dialysis system |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2014106010A9 (en) | 2015-07-02 |
| WO2014106010A1 (en) | 2014-07-03 |
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Application publication date: 20150304 |