CN104383587B - A kind of fullerene/oxidized regenerated cellulose compound hemostatic material and preparation method thereof - Google Patents
A kind of fullerene/oxidized regenerated cellulose compound hemostatic material and preparation method thereof Download PDFInfo
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Abstract
A kind of fullerene/oxidized regenerated cellulose compound hemostatic material and preparation method thereof, it relates to a kind of hemostatic material and preparation method thereof.The material anthemorrhagic performance lifting amplitude that the invention aims to solve existing oxidized regenerated cellulose modified is little, mechanical performance and the problem of bio-absorbable performance inequality.A kind of fullerene/oxidized regenerated cellulose compound hemostatic material is prepared by fullerene and oxidized regenerated cellulose;Preparation method: one, prepare the dispersion liquid of fullerene;Two, compound, obtain fullerene/oxidized regenerated cellulose compound hemostatic material.Fullerene/oxidized regenerated cellulose the compound hemostatic material using the present invention to prepare stops blooding, and bleeding stopping period reduces 7.7%~10%.The present invention can obtain a kind of fullerene/oxidized regenerated cellulose compound hemostatic material and preparation method thereof.
Description
Technical field
The present invention relates to a kind of hemostatic material and preparation method thereof.
Background technology
The most inevitably there is various accident, in carrying out emergency treatment and operation process, all may
Because massive hemorrhage causes malpractice the most dead.Therefore, the topically effective quick-acting haemostatic powder of patient is most important, effectively controls
Make blood and reduce the bleeding time become reduce mortality important measures.Clinical conventional hemostatic material such as hemostatic gauze,
Stanch fibre, tourniquet bandage in use have limitation, as bleeding stopping period is longer, easily with wound adhesion and be difficult to change dressings,
To the infection of wound with suppurate helpless.Quick-acting haemostatic powder and functional hemostasis will be the directions of following haemostatic medicament development.
Conventional Absorbable hemostatic material has Fibrin Glue, gelfoam, oxidized cellulose, microfibrillar collagen, chitosan
And Sorbsan etc..Their mechanism of action and using method are not quite similar, and haemostatic effect also has difference.But, mesh
Before the hemostatic gauze that is widely used clinically be the SURGICEL produced by Johnson & Johnson of the U.S. (Johnson&Johnson) company
Series absorbable hemostatic product SURGICELTM、SURGICELTM Nu-Knit、SURGICELTMFibrillar,
At home also known as " speed i.e. yarn ", the composition of above product is oxidized regenerated cellulose, and main difference is embodied in outward manifestation
Form, SURGICEL series of products have occupied extremely important status the most in the international market now, and receive medical science
The consistent favorable comment of domain expert.Meanwhile, domestic You Ji company has also produced similar hemostatic gauze, but due to material
Performance can not show a candle to speed i.e. yarn, uses expensive import hemostatic material so main clinically.
Oxidized regenerated cellulose is the derivant of cellulose, has good anthemorrhagic performance, biodegradable properties and nontoxic, mesh
Before have been used for multiple industry, including in the medical field, general use nitrogen oxides as oxidant, by cellulose unit
Hydroxyl oxidize on middle C-6 position is that carboxyl prepares oxidized regenerated cellulose.When it uses as hemostatic material, carboxyl-content should
It is 16~24%, to ensure its haemostatic effect.Oxidized regenerated cellulose hemostatic mechanism is as follows: oxidized regenerated cellulose contacts
Can adsorb substantial amounts of erythrocyte after blood, then the acidic carboxypolymer in oxidized regenerated cellulose structure can cause haemolysis, i.e.
Erythrocyte dissolves, ruptures, and discharges hemoglobin.Simultaneously as containing ferric ion, oxidation in hemoglobin
Regenerated cellulose can be with Fe3+In conjunction with forming brown blob of viscose, close, block blood capillary end and stop blooding.As can be seen here,
The hemostasis of oxidized regenerated cellulose is a series of Biochemical Engineering, and the carboxyl quantity in material structure has
Limit, the anthemorrhagic speed therefore causing oxidized regenerated cellulose material is relatively slow, causes such material cannot be applicable to tremulous pulse etc.
The massive hemorrhage situation at position.
During oxidized regenerated cellulose is being continually striving to carry out as the study on the modification of hemostatic material always.Doub et al. discloses
Use the method that oxidized regenerated cellulose is neutralized by the aqueous solution of sodium bicarbonate or calcium acetate, and use thrombin impregnated carbon
The oxidized regenerated cellulose that acid hydrogen sodium neutralizes, then freezes to process and be dried in this case to the fabric after dipping, system
Obtained a kind of efficient oxidized cellulose class surgical operation hemostatic material.In United States Patent (USP), Saferstein et al. describes use
The alcohol-water solution of salt of weak acid, such as sodium acetate, is neutralized to pH value between 5~8, this method by oxidized regenerated cellulose
Not only make oxidized regenerated cellulose can store with ambient-temp-stable, and the acid-sensitive material of similar thrombin can be loaded, enter
And improve the anthemorrhagic performance of oxidized regenerated cellulose material.They also find simultaneously, and Doub et al. uses sodium bicarbonate to neutralize
Method can cause oxidized regenerated cellulose fabrics part gel, deformation, and cause the oxidation regeneration fiber of final neutralization to be knitted
The hot strength of thing is too low to be applied in the hemostasis of reality.And the calcium acetate that Doub et al. mentions in the patent
Although the oxidized regenerated cellulose neutralized ensure that original form of fabric, but due to after neutralizing material calcium content too high, make
The mammal skin of contact position and other somatic cells can be produced zest during with, and use position to form big sending out
White granulation lump, hinders the bio-absorbable of material.
In sum, although the correlational study of oxidized regenerated cellulose is all had a very big significance by above achievement in research, simultaneously
Also the anthemorrhagic performance making material has obtained a certain degree of lifting, but it is typically small to be an up degree, i.e. improves effect poor;
And, the ameliorative way in research also can be to the mechanical strength of regenerated oxycellulose as styptic material and Bioabsorbable in the past
Can adversely affect, for the anthemorrhagic performance promoted by a small margin, modified effect is lost more than gain.
Summary of the invention
The material anthemorrhagic performance lifting amplitude that the invention aims to solve existing oxidized regenerated cellulose modified is little, machinery
Performance and the problem of bio-absorbable performance inequality, and a kind of fullerene/oxidized regenerated cellulose compound hemostatic material and system thereof are provided
Preparation Method.
A kind of fullerene/oxidized regenerated cellulose compound hemostatic material is prepared by fullerene and oxidized regenerated cellulose;Described
The mass ratio of fullerene and oxidized regenerated cellulose be (0.05~10): 100.
The preparation method of a kind of fullerene/oxidized regenerated cellulose compound hemostatic material, is specifically realized by the following steps:
One, prepare the dispersion liquid of fullerene: fullerene powder joined in solvent, then be 160W~400W at ultrasonic power
Supersound process 10min~60min, obtain the dispersion liquid of fullerene;
The quality of the fullerene powder described in step one and the volume ratio of solvent are (0.1mg~2mg): 1mL;
Two, compound: oxidized regenerated cellulose to be immersed in the dispersion liquid of fullerene, is 160W~400W at ultrasonic power
Lower supersound process 10min~60min, then recycling agitator oscillation treatment 6h~32h, then by oxidized regenerated cellulose from
In the dispersion liquid of fullerene take out, then temperature be-70~-20 DEG C at vacuum lyophilization 8h~96h, obtain fullerene/oxidation
Regenerated cellulose compound hemostatic material;
The quality of the oxidized regenerated cellulose described in step 2 with the volume ratio of the dispersion liquid of fullerene is
(0.005~0.04g): 1mL;
Fullerene and oxidized regenerated cellulose in fullerene described in step 2/oxidized regenerated cellulose compound hemostatic material
Mass ratio is (0.05~10): 100;
Advantages of the present invention:
On the basis of one it is contemplated that maintain oxidized regenerated cellulose Absorbable hemostatic material advantage, one is proposed suitableeer
Oxidized regenerated cellulose is modified by suitable method;The present invention is directly to adsorb nanometer at oxidized regenerated cellulose material surface
Fullerene, and then improve the anthemorrhagic performance of oxidized regenerated cellulose, and the mechanical strength of oxidized regenerated cellulose will not be damaged,
Can ensure that again the biological absorbable performance of oxidized regenerated cellulose simultaneously;
Two, the fullerene/oxidized regenerated cellulose compound hemostatic material using the present invention to prepare stops blooding, and bleeding stopping period drops
Low by 7.7%~10%.
The present invention can obtain a kind of fullerene/oxidized regenerated cellulose compound hemostatic material and preparation method thereof.
Detailed description of the invention
Detailed description of the invention one: present embodiment is that a kind of fullerene/oxidized regenerated cellulose compound hemostatic material is by fullerene
Prepare with oxidized regenerated cellulose;Described fullerene is (0.05~10) with the mass ratio of oxidized regenerated cellulose: 100.
The advantage of present embodiment:
One, on the basis of present embodiment is intended to maintain oxidized regenerated cellulose Absorbable hemostatic material advantage, one is proposed more
Add suitable method oxidized regenerated cellulose is modified;Present embodiment is direct at oxidized regenerated cellulose material surface
Absorption nano fullerene, and then improve the anthemorrhagic performance of oxidized regenerated cellulose, and oxidized regenerated cellulose will not be damaged
Mechanical strength, can ensure that again the biological absorbable performance of oxidized regenerated cellulose simultaneously;
Two, the fullerene/oxidized regenerated cellulose compound hemostatic material using present embodiment to prepare stops blooding, during hemostasis
Between reduce 7.7%~10%.
Present embodiment can obtain a kind of fullerene/oxidized regenerated cellulose compound hemostatic material and preparation method thereof.
Detailed description of the invention two: the present embodiment difference from detailed description of the invention one is: described oxidized regenerated cellulose
Middle carboxyl-content is 16%~24%.Other are identical with detailed description of the invention one.
Detailed description of the invention three: the present embodiment difference from detailed description of the invention one or two is: described oxidation regeneration is fine
Dimension element is presented in short silk, long filament or fabric.Other are identical with detailed description of the invention one or two.
Detailed description of the invention four: present embodiment is the preparation side of a kind of fullerene/oxidized regenerated cellulose compound hemostatic material
Method is specifically realized by the following steps:
One, prepare the dispersion liquid of fullerene: fullerene powder joined in solvent, then be 160W~400W at ultrasonic power
Supersound process 10min~60min, obtain the dispersion liquid of fullerene;
The quality of the fullerene powder described in step one and the volume ratio of solvent are (0.1mg~2mg): 1mL;
Two, compound: oxidized regenerated cellulose to be immersed in the dispersion liquid of fullerene, is 160W~400W at ultrasonic power
Lower supersound process 10min~60min, then recycling agitator oscillation treatment 6h~32h, then by oxidized regenerated cellulose from
In the dispersion liquid of fullerene take out, then temperature be-70~-20 DEG C at vacuum lyophilization 8h~96h, obtain fullerene/oxidation
Regenerated cellulose compound hemostatic material;
The quality of the oxidized regenerated cellulose described in step 2 with the volume ratio of the dispersion liquid of fullerene is
(0.005~0.04g): 1mL;
Fullerene and oxidized regenerated cellulose in fullerene described in step 2/oxidized regenerated cellulose compound hemostatic material
Mass ratio is (0.05~10): 100.
The advantage of present embodiment:
One, on the basis of present embodiment is intended to maintain oxidized regenerated cellulose Absorbable hemostatic material advantage, one is proposed more
Add suitable method oxidized regenerated cellulose is modified;Present embodiment is direct at oxidized regenerated cellulose material surface
Absorption nano fullerene, and then improve the anthemorrhagic performance of oxidized regenerated cellulose, and oxidized regenerated cellulose will not be damaged
Mechanical strength, can ensure that again the biological absorbable performance of oxidized regenerated cellulose simultaneously;
Two, the fullerene/oxidized regenerated cellulose compound hemostatic material using present embodiment to prepare stops blooding, during hemostasis
Between reduce 7.7%~10%.
Present embodiment can obtain a kind of fullerene/oxidized regenerated cellulose compound hemostatic material and preparation method thereof.
Detailed description of the invention five: the present embodiment difference from detailed description of the invention four is: the solvent described in step one is
Water, dehydrated alcohol or mass fraction are the ethanol solution of 20%~80%.Other are identical with detailed description of the invention four.
Detailed description of the invention six: the present embodiment difference from detailed description of the invention four or five is: the oxygen described in step 2
Changing carboxyl-content in regenerated cellulose is 16%~24%.Other are identical with detailed description of the invention four or five.
Detailed description of the invention seven: the present embodiment difference from detailed description of the invention four to six is: the oxygen described in step 2
Changing regenerated cellulose is presented in short silk, long filament or fabric.Other are identical with detailed description of the invention four to six.
Detailed description of the invention eight: the present embodiment difference from detailed description of the invention four to seven is: the richness described in step one
The particle diameter strangling alkene powder is 1 μm~200 μm.Other are identical with detailed description of the invention four to seven.
Detailed description of the invention nine: the present embodiment difference from detailed description of the invention four to eight is: the oxygen described in step 2
The volume ratio changing the quality of regenerated cellulose and the dispersion liquid of fullerene is (0.005~0.01g): 1mL.Other and specific embodiment party
Formula four to eight is identical.
Detailed description of the invention ten: the present embodiment difference from detailed description of the invention four to nine is: the richness described in step 2
Strangling the mass ratio of fullerene and oxidized regenerated cellulose in alkene/oxidized regenerated cellulose compound hemostatic material is (1~5): 100.Its
He is identical with detailed description of the invention four to nine.
Employing tests below checking beneficial effects of the present invention:
Test one: the preparation method of a kind of fullerene/oxidized regenerated cellulose compound hemostatic material, the most according to the following steps
Complete:
One, the dispersion liquid of fullerene is prepared: 90mg fullerene powder joined in 300mL dehydrated alcohol, then super
Acoustical power is 200W supersound process 50min, obtains the dispersion liquid of fullerene;
The particle diameter of the fullerene powder described in step one is 1 μm;
Two, compound: 2.5g oxidized regenerated cellulose to be immersed in the dispersion liquid of fullerene, is 280W at ultrasonic power
Lower supersound process 30min, then recycling agitator oscillation treatment 8h, then by oxidized regenerated cellulose from fullerene point
Dissipate in liquid and take out, then vacuum lyophilization 32h at temperature is-50 DEG C, obtain fullerene/oxidized regenerated cellulose compound only
Blood material;
Fullerene and oxidized regenerated cellulose in fullerene described in step 2/oxidized regenerated cellulose compound hemostatic material
Mass ratio is 1.13:100;
In oxidized regenerated cellulose described in step 2, carboxyl-content is 17.36%;
Oxidation regeneration fiber described in step 2 is to exist in the form of a fabric.
Bleeding stopping period measures: after slowly injecting Nembutal sodium solution anesthetized animal by 40mg/kg dose intravenous, by its central authorities
Arteria auricularis region preserved skin, sterilization, cut skin along arteria auricularis direction, and blunt separation goes out arteria auricularis, vein and nerve, then uses
Scalpel transversely cutting tremulous pulse, is pasted on wound surface with 1 layer of test material or control sample and uses immediately after blood is gushed out
Pull and push dynamometer applies the pressure of 3N, observes hemostasis every 10s, until recording bleeding stopping period after final hemostasis completely.
Test result is as follows: the bleeding stopping period using the fabric of the oxidized regenerated cellulose of carboxyl-content 17.36% is 130s, uses
The bleeding stopping period that test one obtains fullerene/oxidized regenerated cellulose compound hemostatic material is 120s.
Test two: the preparation method of a kind of fullerene/oxidized regenerated cellulose compound hemostatic material, the most according to the following steps
Complete:
One, the dispersion liquid of fullerene is prepared: 500mg fullerene powder is joined the second that 500mL mass fraction is 75%
In alcoholic solution, then it is 320W supersound process 60min at ultrasonic power, obtains the dispersion liquid of fullerene;
The particle diameter of the fullerene powder described in step one is 50 μm;
Two, compound: 2.5g oxidized regenerated cellulose to be immersed in the dispersion liquid of fullerene, is 320W at ultrasonic power
Lower supersound process 60min, then recycling agitator oscillation treatment 8h, then by oxidized regenerated cellulose from fullerene point
Dissipate in liquid and take out, then vacuum lyophilization 30h at temperature is-50 DEG C, obtain fullerene/oxidized regenerated cellulose compound only
Blood material;
Fullerene and oxidized regenerated cellulose in fullerene described in step 2/oxidized regenerated cellulose compound hemostatic material
Mass ratio is 4.78:100;
In oxidized regenerated cellulose described in step 2, carboxyl-content is 17.36%;
Oxidation regeneration fiber described in step 2 is to exist in the form of a fabric.
Bleeding stopping period measures: after slowly injecting Nembutal sodium solution anesthetized animal by 40mg/kg dose intravenous, will wherein
Arteria auricularis region, centre preserved skin, sterilization, cut skin along arteria auricularis direction, and blunt separation goes out arteria auricularis, vein and nerve, then
With scalpel transversely cutting tremulous pulse, it is pasted on wound surface with 1 layer of test material or control sample and makes immediately after blood is gushed out
Apply the pressure of 3N by pull and push dynamometer, observe hemostasis every 10s, until recording bleeding stopping period after final hemostasis completely.
Test result is as follows: the bleeding stopping period using the fabric of the oxidized regenerated cellulose of carboxyl-content 17.36% is 130s, test
Two bleeding stopping period obtaining fullerene/oxidized regenerated cellulose compound hemostatic material are 117s.
Claims (2)
1. the preparation method of fullerene/oxidized regenerated cellulose compound hemostatic material, it is characterised in that a kind of fullerene/oxygen
The preparation method of change regenerated cellulose compound hemostatic material is specifically realized by the following steps:
One, the dispersion liquid of fullerene is prepared: 90mg fullerene powder joined in 300mL dehydrated alcohol, then ultrasonic
Power is 200W supersound process 50min, obtains the dispersion liquid of fullerene;
The particle diameter of the fullerene powder described in step one is 1 μm;
Two, compound: 2.5g oxidized regenerated cellulose to be immersed in the dispersion liquid of fullerene, under ultrasonic power is 280W
Supersound process 30min, then recycling agitator oscillation treatment 8h, then by oxidized regenerated cellulose from the dispersion liquid of fullerene
Middle taking-up, then vacuum lyophilization 32h at temperature is-50 DEG C, obtain fullerene/oxidized regenerated cellulose compound hemostatic material;
Fullerene and oxidized regenerated cellulose in fullerene described in step 2/oxidized regenerated cellulose compound hemostatic material
Mass ratio is 1.13:100;
In oxidized regenerated cellulose described in step 2, carboxyl-content is 17.36%;
Oxidation regeneration fiber described in step 2 is to exist in the form of a fabric.
2. a preparation method for fullerene/oxidized regenerated cellulose compound hemostatic material, a kind of fullerene/oxidation regeneration fiber
The preparation method of element compound hemostatic material is specifically realized by the following steps:
One, the dispersion liquid of fullerene is prepared: 500mg fullerene powder is joined the second that 500mL mass fraction is 75%
In alcoholic solution, then it is 320W supersound process 60min at ultrasonic power, obtains the dispersion liquid of fullerene;
The particle diameter of the fullerene powder described in step one is 50 μm;
Two, compound: 2.5g oxidized regenerated cellulose to be immersed in the dispersion liquid of fullerene, under ultrasonic power is 320W
Supersound process 60min, then recycling agitator oscillation treatment 8h, then by oxidized regenerated cellulose from the dispersion liquid of fullerene
Middle taking-up, then vacuum lyophilization 30h at temperature is-50 DEG C, obtain fullerene/oxidized regenerated cellulose compound hemostatic material;
Fullerene and oxidized regenerated cellulose in fullerene described in step 2/oxidized regenerated cellulose compound hemostatic material
Mass ratio is 4.78:100;
In oxidized regenerated cellulose described in step 2, carboxyl-content is 17.36%;
Oxidation regeneration fiber described in step 2 is to exist in the form of a fabric.
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CN102791259A (en) * | 2010-03-09 | 2012-11-21 | 纳诺西斯有限公司 | Nanostructure-enhanced platelet binding and hemostatic materials and structures |
CN103025950A (en) * | 2010-08-18 | 2013-04-03 | 科德宝两合公司 | Method for the production of oxidized cellulose fibers, oxidized cellulose fiber sheet materials or oxidized cellulose nonwovens, and use thereof |
CN103418019A (en) * | 2013-08-13 | 2013-12-04 | 威海洁瑞医用制品有限公司 | Zwitterionic modified oxidized regenerated cellulose absorbable hemostatic material and preparation method thereof |
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CN102791259A (en) * | 2010-03-09 | 2012-11-21 | 纳诺西斯有限公司 | Nanostructure-enhanced platelet binding and hemostatic materials and structures |
CN103025950A (en) * | 2010-08-18 | 2013-04-03 | 科德宝两合公司 | Method for the production of oxidized cellulose fibers, oxidized cellulose fiber sheet materials or oxidized cellulose nonwovens, and use thereof |
CN103418019A (en) * | 2013-08-13 | 2013-12-04 | 威海洁瑞医用制品有限公司 | Zwitterionic modified oxidized regenerated cellulose absorbable hemostatic material and preparation method thereof |
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