CN104383581A - Wound protecting composition with bleeding-stopping and anti-bacterial functions and preparation method of wound protecting composition - Google Patents
Wound protecting composition with bleeding-stopping and anti-bacterial functions and preparation method of wound protecting composition Download PDFInfo
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- CN104383581A CN104383581A CN201410634763.1A CN201410634763A CN104383581A CN 104383581 A CN104383581 A CN 104383581A CN 201410634763 A CN201410634763 A CN 201410634763A CN 104383581 A CN104383581 A CN 104383581A
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Abstract
The invention discloses a wound protecting composition with bleeding-stopping and anti-bacterial functions and a preparation method of the wound protecting composition. The wound protecting composition comprises the following steps: (1) preparing an organic high molecular mixed solution; (2) adding one or two of chitosan and chitin into acetic acid, ethanol and water so as to prepare a bleeding-stopping and anti-bacterial material solution; (3) carrying out multi-spray-head electrostatic spinning so as to prepare a composite fiber material; and (4) drying the composite fiber material, removing residual solvents, and carrying out hot-press shaping, so as to prepare the wound protecting composition with the bleeding-stopping and anti-bacterial functions. The wound protecting composition disclosed by the invention has good bleeding-stopping and anti-bacterial effects, can be used for cleaning wounds and is good in biocompatibility; the water absorption rate is obviously increased, the bleeding-stopping time is greatly shortened, and the wounds are further protected.
Description
Technical field
The present invention relates to Wound protection technical field of compositions, particularly relate to one and there is hemostatic bacteriostatic function Wound protection composition and method of making the same.
Background technology
General operative incision or wound are divided into following three classes, and 1, clean cut, with " I " representative, refer to non-wound that is traumatic, that do not infect; Operation does not enter respiratory tract, digestive tract, urogenital tract and oropharynx position.Both the aseptic incision of stitching had been referred to, as subtotal thyroidectomy etc.The otch that 2, may pollute, with " II " representative, may pollution-carryingly sew up the incision, as subtotal gastrectomy etc. when referring to operation.Skin be not easy thorough sterilizing position, in 6 hours wound sew up through debridement, the new otch sewed up dissector once again again, all belong to this type of.3, contamination of incision, uses " III " representative, refers to the otch closing on infected area or organize directly exposure and infectious agent, as the operation of suppurative appendicitis operation, intestinal obstruction necrosis, the old wound wound etc. locally containing slough.Its healing of otch that pollution level is larger is more difficult, more should take necessary protective measure.According to the healing state of different incisions, its healing also can be divided into following three grades: 1, Wound healing by first intention, with " first " representative, refers to that healing is excellent, does not have the initial stage of untoward reaction to heal.2, second class healing, with " second " representative, refer to that healing is not good enough, healing place has inflammatory reaction, does not suppurate as redness, scleroma, hematoma, hydrops etc.3, third class healing, with " third " representative, refers to that otch suppurates, needs incision and drainage.The mode that the degree of damage and the regeneration capacity of tissue determine to repair, the time of healing and the size of cicatrix.Therefore, Therapeutic Principle reduces wound surface (as involutory wound) as early as possible, prevents from damaging and promoting tissue regeneration.Although the regeneration capacity of tissue obtains during evolution, but still be subject to the impact of whole body and local condition.Therefore, should avoid some unfavorable factors, create favorable conditions promotion regeneration and restoration.In addition, because scar tissue can work the mischief under certain condition, thus sometimes need suppress the formation of cicatrix or promote the absorption of cicatrix, comprise and adopt hemostatic fashion fast and effectively, suitable infection process, rational promotion fibrinolytic system work, gives somatomedin, adopts anti means to prevent the measures such as cut out portion and its hetero-organization stick together.
Existing adherence preventing material or the Wound protection material of having gone on the market, what compare accreditation is all membrane material, although preventing adhesiving effect is definite, has clear and definite contraindication, i.e. infected wound and active hemorrhage wound forbidding.For two classes, three class infected wounds, inflammation and hemorrhagely general adherence preventing material all can be caused to lose efficacy, infects simultaneously and oozing of blood can cause wound healing slow, even causes suppurative wound, causes wound slowly cannot heal.
We urgently find a kind of suitable composite high-molecular material and prepare Wound protection material at present, and prepared material has suitable mechanical strength, reach effect of hemostasis, antibacterial, prevention of postoperative adhesion, protection wound, simultaneously healing acceleration.
Summary of the invention
In view of this; the invention provides a kind of preparation method with hemostatic bacteriostatic function Wound protection compositions; this preparation method utilizes electrostatic spinning technique hemostatic bacteriostatic powder body and fibrous membrane to be effectively combined and obtains has hemostatic bacteriostatic function Wound protection compositions; specifically adopt identical preparation means to produce different electrostatic spinning form on the same device simultaneously; time processing molding, ensures that bi-material has good adhesion simultaneously.
There is a preparation method for hemostatic bacteriostatic function Wound protection compositions, comprise the following steps:
(1) organic polymer mixed solution is prepared: organic polymer is dissolved in any one organic solvent in DMF, acetone, THF, hexafluoroisopropanol, stirs, join and to obtain organic polymer mixed solution;
(2) hemostatic bacteriostatic material solution is prepared: one or both join in acetic acid, second alcohol and water and are made into hemostatic bacteriostatic material solution by chitosan, chitin;
(3) complex fiber material is prepared: described organic polymer mixed solution is injected electrospinning device syringe, install syringe needle, described hemostatic bacteriostatic material solution is injected electrospinning device syringe, install syringe needle, and multi-nozzle electrospinning is carried out in two kinds of syringe needle intervals placements, obtained complex fiber material;
(4) described complex fiber material is dry, removing residual solvent, thermocompression forming, obtained there is hemostatic bacteriostatic function Wound protection compositions.
Mass/volume concentration in the present invention, in g/mL, namely above solute in g, after solvent volume in mL, obtain mass/volume concentration.
Preferably, in step (1), organic polymer is one or both mixture in Poly(D,L-lactide-co-glycolide, polylactic acid.
Preferably, the detailed process of step (1) is: to be dissolved in by organic polymer in DMF, acetone, THF, hexafluoroisopropanol in any one organic solvent, at 18 ~ 22 DEG C, stir 12h, be mixed with the organic polymer mixed solution that mass/volume concentration is 20 ~ 50%.
Preferably, the detailed process of step (2) is: by chitosan, chitin, one or both join acetic acid, second alcohol and water is mixed with the hemostatic bacteriostatic material solution that concentration is 0.5 ~ 10%;
Wherein, acetic acid volume is 1 ~ 5% of total solvent volume, and the volume ratio of ethanol and water is 1:1 ~ 10.
Preferably, the detailed process of step (3) is: described organic polymer mixed solution is injected respectively electrospinning device 5 ~ 8 syringes, install No. 5 rustless steel syringe needles, described hemostatic bacteriostatic material solution is injected respectively electrospinning device 3 ~ 4 syringes, install No. 5 rustless steel syringe needles, and spaced for the syringe needle being marked with two kinds of solution one or two are placed, multi-nozzle electrospinning 20 ~ 180min is carried out under being the condition of 5 ~ 25cm, obtained complex fiber material at voltage 10 ~ 30KV, solution flow rate 1 ~ 5mL/h, receiving range.
The organic polymer that described complex fiber material is 5 ~ 500,000 by weight average molecular weight is formed.
Preferably, the detailed process of step (4) is: by described complex fiber material vacuum drying 24 ~ 48h at 18 ~ 22 DEG C, removing residual solvent, thermocompression forming 20min at 50 DEG C, and obtained have hemostatic bacteriostatic function Wound protection compositions.
The present invention provide on the other hand a kind of adopt above-mentioned preparation method to prepare there is hemostatic bacteriostatic function Wound protection compositions; special hemostasis sterilizes powder body by uniform adsorption on fibrous membrane top layer; effectively be fixed in fibrous membrane; fibrous membrane has rational aperture; can lure that mesothelial cell breeds into, hinder fibroblast to adhere to.This Wound protection compositions has good hemostasis, antibacterial, antibacterial effect, clean wound, and good biocompatibility, rate of water absorption significantly improve, greatly shorten bleeding stopping period, protect wound further.
Beneficial effect of the present invention: a kind of preparation method with hemostatic bacteriostatic function Wound protection compositions, comprise (1) preparation organic polymer mixed solution: organic polymer is dissolved in any one organic solvent in DMF, acetone, THF, hexafluoroisopropanol, stirs, join and to obtain organic polymer mixed solution; (2) hemostatic bacteriostatic material solution is prepared: one or both join in acetic acid, second alcohol and water and are made into hemostatic bacteriostatic material solution by chitosan, chitin; (3) complex fiber material is prepared: described organic polymer mixed solution is injected electrospinning device syringe, install syringe needle, described hemostatic bacteriostatic material solution is injected electrospinning device syringe, install syringe needle, and multi-nozzle electrospinning is carried out in two kinds of syringe needle intervals placements, obtained complex fiber material; (4) described complex fiber material is dry, removing residual solvent, thermocompression forming, obtained there is hemostatic bacteriostatic function Wound protection compositions.The present invention utilizes electrostatic spinning technique hemostatic bacteriostatic powder body and fibrous membrane to be effectively combined and obtains has hemostatic bacteriostatic function Wound protection compositions, specifically adopt identical preparation means to produce different electrostatic spinning form on the same device simultaneously, time processing molding, ensures that bi-material has good adhesion simultaneously; This blood bacteria resistance function Wound protection compositions has good hemostasis, antibacterial, antibacterial effect, clean wound, and good biocompatibility, rate of water absorption significantly improve, greatly shorten bleeding stopping period, protect wound further.
Detailed description of the invention
Further illustrate technical scheme of the present invention respectively below in conjunction with the embodiments.
Raw material involved in following examples is commercially available.
Embodiment 1: the preparation method with hemostatic bacteriostatic function Wound protection compositions of the present embodiment, comprises the following steps:
One or both mixture in Poly(D,L-lactide-co-glycolide, polylactic acid to be dissolved in DMF, acetone, THF, hexafluoroisopropanol in any one organic solvent, at 18 DEG C, stir 12h, be mixed with the organic polymer mixed solution that mass/volume concentration is 20%.
By in chitosan, chitin, one or both join in acetic acid, second alcohol and water and are mixed with the hemostatic bacteriostatic material solution that concentration is 0.5%, and wherein, acetic acid volume is 1% of total solvent volume, and the volume ratio of ethanol and water is 1:1.
Described organic polymer mixed solution is injected respectively electrospinning device 5 syringes, install No. 5 rustless steel syringe needles, hemostatic bacteriostatic material solution is injected respectively electrospinning device 3 syringes, install No. 5 rustless steel syringe needles, and spaced for the syringe needle being marked with two kinds of solution one or two are placed, multi-nozzle electrospinning 20min is carried out under being the condition of 5cm, obtained complex fiber material at voltage 10KV, solution flow rate 1mL/h, receiving range.
By described complex fiber material vacuum drying 24h at 18 DEG C, removing residual solvent, thermocompression forming 20min at 50 DEG C, obtained have hemostatic bacteriostatic function Wound protection compositions.
Embodiment 2: the preparation method with hemostatic bacteriostatic function Wound protection compositions of the present embodiment, comprises the following steps:
One or both mixture in Poly(D,L-lactide-co-glycolide, polylactic acid to be dissolved in DMF, acetone, THF, hexafluoroisopropanol in any one organic solvent, at 20 DEG C, stir 12h, be mixed with the organic polymer mixed solution that mass/volume concentration is 30%.
By in chitosan, chitin, one or both join in acetic acid, second alcohol and water and are mixed with the hemostatic bacteriostatic material solution that concentration is 5%; Wherein, acetic acid volume is 2% of total solvent volume, and the volume ratio of ethanol and water is 1:5.
Described organic polymer mixed solution is injected respectively electrospinning device 6 syringes, install No. 5 rustless steel syringe needles, described hemostatic bacteriostatic material solution is injected respectively electrospinning device 4 syringes, install No. 5 rustless steel syringe needles, and spaced for the syringe needle being marked with two kinds of solution one or two are placed, multi-nozzle electrospinning 90min is carried out under being the condition of 15cm, obtained complex fiber material at voltage 20KV, solution flow rate 3mL/h, receiving range.
By described complex fiber material vacuum drying 36h at 20 DEG C, removing residual solvent, thermocompression forming 20min at 50 DEG C, obtained have hemostatic bacteriostatic function Wound protection compositions.
Embodiment 3: the preparation method with hemostatic bacteriostatic function Wound protection compositions of the present embodiment, comprises the following steps:
One or both mixture in Poly(D,L-lactide-co-glycolide, polylactic acid to be dissolved in DMF, acetone, THF, hexafluoroisopropanol in any one organic solvent, at 22 DEG C, stir 12h, be mixed with the organic polymer mixed solution that mass/volume concentration is 50%.
By in chitosan, chitin, one or both join in acetic acid, second alcohol and water and are mixed with the hemostatic bacteriostatic material solution that concentration is 10%;
Wherein, acetic acid volume is 5% of total solvent volume, and the volume ratio of ethanol and water is 1:10.
Described organic polymer mixed solution is injected respectively electrospinning device 8 syringes, install No. 5 rustless steel syringe needles, described hemostatic bacteriostatic material solution is injected respectively electrospinning device 4 syringes, install No. 5 rustless steel syringe needles, and spaced for the syringe needle being marked with two kinds of solution one or two are placed, multi-nozzle electrospinning 180min is carried out under being the condition of 25cm, obtained complex fiber material at voltage 30KV, solution flow rate 5mL/h, receiving range.
By described complex fiber material vacuum drying 48h at 22 DEG C, removing residual solvent, thermocompression forming 20min at 50 DEG C, obtained have hemostatic bacteriostatic function Wound protection compositions.
Adopt the general method of testing in this area to having hemostatic bacteriostatic function Wound protection compositions in embodiment 1 ~ 3 and spongy body Wound protection compositions carries out bleeding stopping period and bacteriostasis rate measures, measurement result is as follows:
As can be seen from the above table, of the present invention have hemostatic bacteriostatic function Wound protection compositions bleeding stopping period soon, antibacterial, good anti-bacterial effect.
The present invention adopts anti-adhesion fiber membrane and chitin/chitosan hemostatic material effectively in conjunction with obtained Wound protection compositions; can fast rapid-result gel adheres in wound surface; haemostatic effect is definite; hemostasis speed is fast; and have clear and definite bacteriostasis antibiosis effect at the wound healing initial stage; the fibrous membrane being loaded with chitin/chitosan powder body not only can effectively protect wound not with other tissue adhesions, can also wound healing be accelerated, and inducing wound healing is to one-level healing future development.
Blood bacteria resistance function Wound protection compositions prepared by the present invention has good hemostasis, antibacterial, antibacterial effect, clean wound, and good biocompatibility, rate of water absorption significantly improve, greatly shorten bleeding stopping period, protect wound further.
It should be noted that and understand, when not departing from the spirit and scope of accompanying claim the present invention for required protection, various amendment and improvement can be made to the present invention of foregoing detailed description.Therefore, the scope of claimed technical scheme is not by the restriction of given any specific exemplary teachings.
Applicant states, the present invention illustrates detailed process equipment and process flow process of the present invention by above-described embodiment, but the present invention is not limited to above-mentioned detailed process equipment and process flow process, namely do not mean that the present invention must rely on above-mentioned detailed process equipment and process flow process and could implement.Person of ordinary skill in the field should understand, any improvement in the present invention, to equivalence replacement and the interpolation of auxiliary element, the concrete way choice etc. of each raw material of product of the present invention, all drops within protection scope of the present invention and open scope.
Claims (7)
1. there is a preparation method for hemostatic bacteriostatic function Wound protection compositions, it is characterized in that, comprise the following steps:
(1) organic polymer mixed solution is prepared: organic polymer is dissolved in any one organic solvent in DMF, acetone, THF, hexafluoroisopropanol, stirs, join and to obtain organic polymer mixed solution;
(2) hemostatic bacteriostatic material solution is prepared: one or both join in acetic acid, second alcohol and water and are made into hemostatic bacteriostatic material solution by chitosan, chitin;
(3) complex fiber material is prepared: described organic polymer mixed solution is injected electrospinning device syringe, installs syringe needle; Described hemostatic bacteriostatic material solution is injected electrospinning device syringe, installs syringe needle; And multi-nozzle electrospinning is carried out in two kinds of syringe needle intervals placements, obtained complex fiber material;
(4) described complex fiber material is dry, removing residual solvent, thermocompression forming, obtained there is hemostatic bacteriostatic function Wound protection compositions.
2. preparation method according to claim 1, is characterized in that, in step (1), described organic polymer is one or both mixture in Poly(D,L-lactide-co-glycolide, polylactic acid.
3. preparation method according to claim 1, it is characterized in that, the detailed process of step (1) is: to be dissolved in by organic polymer in DMF, acetone, THF, hexafluoroisopropanol in any one organic solvent, at 18 ~ 22 DEG C, stir 12h, be mixed with the organic polymer mixed solution that mass/volume concentration is 20 ~ 50%.
4. preparation method according to claim 1, it is characterized in that, the detailed process of step (2) is: by chitosan, chitin, one or both join in acetic acid, second alcohol and water and are mixed with the hemostatic bacteriostatic material solution that concentration is 0.5 ~ 10%;
Wherein, acetic acid volume is 1 ~ 5% of total solvent volume, and the volume ratio of ethanol and water is 1:1 ~ 10.
5. preparation method according to claim 1, it is characterized in that, the detailed process of step (3) is: described organic polymer mixed solution is injected respectively electrospinning device 5 ~ 8 syringes, each syringe installs No. 5 rustless steel syringe needles; Described hemostatic bacteriostatic material solution is injected respectively electrospinning device 3 ~ 4 syringes, each syringe installs No. 5 rustless steel syringe needles; And spaced for the syringe needle being marked with two kinds of solution one or two are placed, carry out multi-nozzle electrospinning 20 ~ 180min at voltage 10 ~ 30KV, solution flow rate 1 ~ 5mL/h, receiving range under being the condition of 5 ~ 25cm, obtained complex fiber material.
6. preparation method according to claim 1; it is characterized in that; the detailed process of step (4) is: by described complex fiber material vacuum drying 24 ~ 48h at 18 ~ 22 DEG C; removing residual solvent; thermocompression forming 20min at 50 DEG C, obtained have hemostatic bacteriostatic function Wound protection compositions.
7. one kind adopt any one of claim 1 ~ 6 preparation method to prepare there is hemostatic bacteriostatic function Wound protection compositions.
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| CN201410634763.1A CN104383581A (en) | 2014-11-12 | 2014-11-12 | Wound protecting composition with bleeding-stopping and anti-bacterial functions and preparation method of wound protecting composition |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113304302A (en) * | 2021-05-25 | 2021-08-27 | 南通大学 | Anti-adhesion medical dressing for promoting healing of high-exudative wound and preparation method thereof |
| CN113368296A (en) * | 2021-06-02 | 2021-09-10 | 李昌荣 | Sanitary gauze produced based on degradable fibers and production process thereof |
| CN113481621A (en) * | 2021-08-23 | 2021-10-08 | 泉州师范学院 | Wound hemostasis composite material, preparation method and application thereof |
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| CN102552976A (en) * | 2012-02-20 | 2012-07-11 | 汪泱 | Tissue engineering bracket material capable of physically embedding active substances and preparation method thereof |
| CN103611195A (en) * | 2013-11-21 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Self-adhesion hemostasis anti-adhesion corpus fibrosum |
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- 2014-11-12 CN CN201410634763.1A patent/CN104383581A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552976A (en) * | 2012-02-20 | 2012-07-11 | 汪泱 | Tissue engineering bracket material capable of physically embedding active substances and preparation method thereof |
| CN103611195A (en) * | 2013-11-21 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Self-adhesion hemostasis anti-adhesion corpus fibrosum |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113304302A (en) * | 2021-05-25 | 2021-08-27 | 南通大学 | Anti-adhesion medical dressing for promoting healing of high-exudative wound and preparation method thereof |
| CN113368296A (en) * | 2021-06-02 | 2021-09-10 | 李昌荣 | Sanitary gauze produced based on degradable fibers and production process thereof |
| CN113481621A (en) * | 2021-08-23 | 2021-10-08 | 泉州师范学院 | Wound hemostasis composite material, preparation method and application thereof |
| CN113481621B (en) * | 2021-08-23 | 2023-03-10 | 泉州师范学院 | Wound hemostasis composite material, preparation method and application thereof |
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Application publication date: 20150304 |