CN104375106B - The method for shimming and shimming system of a kind of MR imaging apparatus - Google Patents
The method for shimming and shimming system of a kind of MR imaging apparatus Download PDFInfo
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- CN104375106B CN104375106B CN201310353966.9A CN201310353966A CN104375106B CN 104375106 B CN104375106 B CN 104375106B CN 201310353966 A CN201310353966 A CN 201310353966A CN 104375106 B CN104375106 B CN 104375106B
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Abstract
Embodiment of the present invention discloses the method for shimming and shimming system of a kind of MR imaging apparatus.Method includes：Detect the main field inhomogeneities of MR imaging apparatus；Calculate the 3D structural informations and the positional information of shimming mechanism of the shimming mechanism of the compensation main field inhomogeneities；The shimming mechanism for meeting the 3D structural informations is printed using 3D printing method；The shimming mechanism is arranged in around the magnet of MR imaging apparatus according to the shimming mechanism positional information.Embodiment of the present invention shimming effect more preferably, is not usually required to multiple shimming, and ferromagnetism and insulating materials in shimming mechanism can arbitrarily mix to reduce vortex.
Description
Technical field
The present invention relates to magnetic resonance (MRI) technical field, more particularly to a kind of method for shimming of MR imaging apparatus
With shimming system.
Background technology
Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) is with computer technology, electronic circuit skill
Art, the development of superconduction body technique and a kind of biomagnetism nuclear spin imaging technique for developing rapidly.It using magnetic field with penetrate
Frequency pulse makes the proton (i.e. H+) of precession in tissue that nutating generation radiofrequency signal to occur, and is processed through computer and is imaged.When
Object is placed in magnetic field, with appropriate electromagnetic wave irradiation it, be allowed to resonate, then analyze it discharge electromagnetic wave, so that it may
Nuclear position and the species of this object are constituted to learn, the accurate stereo-picture of interior of articles can be depicted as accordingly.
Such as, the animation for serial section that can be obtained by MRI scan human brain, by the crown, until
Base portion.
Due to the influence of ferromagnetic material and foozle around magnet, generally master is had in MR imaging apparatus
Magnetic field inhomogeneity (main field inhomogeneity) problem.In the prior art, typically arranged by around magnet
The ferromagnetic material of correct amount compensates the inhomogeneities of main field.These ferrimagnets are usually sheet or other are easy to
The regular shape of installation, and ferrimagnet typically has several different thickness and size.When measuring main field not
After uniformity, the number and placement location of the ferrimagnet of different size/thickness can be calculated, be carried out with to main field
Compensation.And, separate to prevent gradient fields from forming maelstrom when switching with insulating materials typically between ferrimagnet.
However, being installed for convenience of installation engineer, ferrimagnet that shimming is used and the size of insulating materials are not
Can ether it is small, its surface area be usually dozens of square centimeter or more yardstick, which limits the precision of shimming, it is difficult to mend
The trickle inhomogeneities of main field is repaid, also therefore resulting in the need for multiple shimming can be only achieved requirement.
And, when the gradient magnetic used by magnetic resonance system is switched over, metal material in magnet (including shimming
Ferrimagnet) internal can produce vortex.And ferrimagnet can not ether be small causes its internal vortex for producing can not to neglect
Depending on.
Further, when shimming material (including ferromagnetism and insulating materials) is assembled on MR imaging apparatus,
Operating personnel are careful to count, correct with the size and number for ensuring the shimming material that each interval the inside is placed, and this
Process easily malfunctions.
The content of the invention
Embodiment of the present invention proposes a kind of method for shimming of MR imaging apparatus, improves compensation main field inhomogeneities
Precision.
Embodiment of the present invention proposes a kind of shimming system of MR imaging apparatus, improves compensation main field inhomogeneities
Precision.
The technical scheme of embodiment of the present invention is as follows：
A kind of method for shimming of MR imaging apparatus, the method includes：
Detect the main field inhomogeneities of MR imaging apparatus；
Calculate the 3D structural informations of the shimming mechanism of the compensation main field inhomogeneities and the position letter of shimming mechanism
Breath；
The shimming mechanism for meeting the 3D structural informations is printed using 3D printing method；
The shimming mechanism is arranged in around the magnet of MR imaging apparatus according to the shimming mechanism positional information.
The shimming mechanism includes ferromagnetic material.
The shimming mechanism includes insulating properties material.
The ferromagnetic material is the line or powder for including metal or metallic compound.
The insulating properties material is to include the line of plastic material or powder.
The plastic material is resin.
A kind of shimming system of MR imaging apparatus, the system includes a magnetic field detectors, a computing unit and a 3D
Printer, wherein：
The magnetic field detectors, the main field inhomogeneities for detecting MR imaging apparatus；
The computing unit, for calculate the shimming mechanism of the compensation main field inhomogeneities 3D structural informations and
The positional information of shimming mechanism；
The 3D printer, the shimming mechanism of the 3D structural informations is met for printing；
According to the positional information of the shimming mechanism, the shimming mechanism is located at around the magnet of MR imaging apparatus.
There is the magnetic field detectors multiple to be distributed in the detection of magnetic field head among MR imaging apparatus.
The 3D printer, for being burnt by stereolithography mode, fused glass pellet mode or selective laser
Knot mode prints the shimming mechanism for meeting the 3D structural informations.
Further include arrangement unit,
The arrangement unit, for the shimming mechanism to be arranged in into magnetic resonance imaging according to the shimming mechanism positional information
Around the magnet of device.
The shimming mechanism includes ferromagnetic material and/or insulating properties material.
From above-mentioned technical proposal as can be seen that in embodiments of the present invention, detecting the main field of MR imaging apparatus
Inhomogeneities；Calculate the 3D structural informations and shimming mechanism position letter of the shimming mechanism of the compensation main field inhomogeneities
Breath；The shimming mechanism for meeting the 3D structural informations is printed using 3D printing method；Will according to the shimming mechanism positional information
The shimming mechanism is arranged in around the magnet of MR imaging apparatus.3D structural informations of the invention and shimming mechanism position
Information compared to existing technology can be more accurate, and shimming effect also can be more preferable, is not usually required to multiple shimming.
And, in embodiments of the present invention, ferromagnetism and insulating materials in shimming mechanism arbitrarily can mix to subtract
Few vortex, and by 3D automatic printing shimming mechanisms, cost of labor can be significantly reduced and installation effectiveness is improved.
Brief description of the drawings
Fig. 1 is the method for shimming flow chart according to embodiment of the present invention MR imaging apparatus.
Fig. 2 is the shimming system construction drawing according to embodiment of the present invention MR imaging apparatus.
Specific embodiment
In order that technical scheme and advantage become more apparent, below in conjunction with drawings and the embodiments, to this
Invention is further elaborated.It should be appreciated that specific embodiment described herein only illustrates this to illustrative
Invention, the protection domain being not intended to limit the present invention.
Fig. 1 is the method for shimming flow chart according to embodiment of the present invention MR imaging apparatus.
As shown in figure 1, the method includes：
Step 101：Detect the main field inhomogeneities of MR imaging apparatus.
Herein, it is possible to use various magnetic field detectors detect the main field inhomogeneities of MR imaging apparatus.Magnetic field
Preferably there is detector multiple to be distributed in the detection of magnetic field head among MR imaging apparatus.Each detection of magnetic field head is separately detected
The magnetic field of itself position.Magnetic field detectors can be based on the Magnetic Field that each detection of magnetic field head is converged, and determine main magnetic
Field inhomogeneities.
Step 102：Calculate the 3D structural informations and shimming mechanism of the shimming mechanism of the compensation main field inhomogeneities
Positional information.
Herein, the compensation master can theoretically be calculated based on identified main field inhomogeneities in step 101
The 3D structural informations and shimming mechanism positional information of the shimming mechanism of magnetic field bump.
3D structural informations are included：The particulate size of ferromagnetic material and insulating materials in shimming mechanism, and ferromagnetism
The mutual alignment information of material and insulating materials；Relative position of the shimming mechanism positional information comprising shimming mechanism with magnet.
In the result of calculation of 3D structural informations, the size of ferromagnetic material and insulating materials can be very small, therefore 3D
The result of calculation of structural information can reach precision very high, and ferromagnetism and Ins. ulative material can also arbitrarily mix
To reduce vortex.Such as, ferrimagnet and Ins. ulative material can be (such as various tiny with the size much smaller than prior art
Grain shape) mix, and because the size of ferrimagnet and Ins. ulative material is smaller, ferrimagnet and insulating properties material
Expect that the distribution in shimming mechanism can also be more extensive and accurate.3D printing technique can support that each voxel is
0.1mm3Or precision higher, the granular-grade yardstick is much smaller than traditional shimming sheet block, therefore 3D structural informations of the invention
And shimming mechanism positional information compared to existing technology can be more accurate, shimming effect also can be more preferable.
Shimming mechanism can be made up of ferromagnetic material and insulating properties material, wherein ferromagnetic material can be by metal or
Line or powder that metallic compound is constituted, and insulating properties material can be the line or powder being made up of plastic material.
Enumerate the composition example of ferromagnetic material and insulating properties material, those skilled in the art in detail above it is to be appreciated that
It is this to enumerate only exemplary, it is not used to be defined embodiment of the present invention.
Step 103：The shimming mechanism for meeting the 3D structural informations is printed using 3D printing method.
Herein, it is possible to use 3D printing method prints the shimming mechanism for meeting the 3D structural informations.
3D printing technique is with 3D structural informations as source, by the way that software hierarchy is discrete and numerical control molding system, using swashing
The modes such as light beam, hot melt nozzle are successively piled up the special materials such as metal dust, ceramic powders coheres, and is finally superimposed as
Type, produces entity products.
Herein, it is possible to use stereolithography mode, fused glass pellet mode or selective laser sintering mode,
The shimming mechanism for meeting the 3D structural informations is printed etc. various printing types.
In stereolithography mode, advantage is high precision, can show accurate surface and smooth effect, precision
0.05 millimeter to 0.15 millimeter of every thickness degree can be reached.
In fused glass pellet mode, material high temperature melting into liquid, then squeezed out one by one by nozzle
The spherical particle of very little, these particles solidify immediately after ejection, and the permutation and combination by these particles in solid space is formed
It is in kind.
In selective laser sintering mode, shaped using dusty material.Material powder paving is sprinkled upon formed zero
The upper surface of part, and strike off；With the CO2 lasers of high intensity part section is scanned on the new layer of firm paving；Material powder exists
It is sintered together under the laser irradiation of high intensity, obtains the section of part, and it is Nian Jie with following formed part；When one layer
After section has sintered, new layer of material powder is spread, selectively sinter lower layer cross section.
The example of specific 3D printing method, those skilled in the art are enumerated in detail above it is to be appreciated that this enumerate only
It is exemplary, is not used to be defined embodiment of the present invention.
Step 104：The shimming mechanism is arranged in by MR imaging apparatus according to the shimming mechanism positional information
Around magnet.
Herein, it is possible to use manually shimming mechanism is arranged in around the magnet corresponding to shimming mechanism positional information,
Shimming mechanism can also be arranged in around the magnet corresponding to shimming mechanism positional information by controlled mechanical automation.
In various situations MR imaging apparatus can be performed with above-mentioned shimming operation.Such as, filled in magnetic resonance imaging
In the production process put, or MR imaging apparatus it is specifically used during can carry out the operation of above-mentioned shimming.Magnetic resonance
Imaging device dispatch from the factory before whether shimming, after the site environments such as hospital are transported to, due to space enrironment (temperature or magnetic
The presence of property material) change so that the uniformity in magnetic field makes variation, therefore in order to reach the uniformity of magnetic field of requirement, generally
Need to be directed to MR imaging apparatus shimming again.Only reach the uniformity of magnetic field of requirement, MR imaging apparatus could be into
Blur-free imaging.
Based on above-mentioned labor, embodiment of the present invention also proposed a kind of shimming system of MR imaging apparatus.
Fig. 2 is the shimming system construction drawing according to embodiment of the present invention MR imaging apparatus.
As shown in Fig. 2 the system includes magnetic field detectors 201, computing unit 202 and 3D printer 203, wherein：
Magnetic field detectors 201, the main field inhomogeneities for detecting MR imaging apparatus；
Computing unit 202, for calculate the shimming mechanism of the compensation main field inhomogeneities 3D structural informations and
Shimming mechanism positional information；
3D printer 203, the shimming mechanism of the 3D structural informations is met for printing；The shimming mechanism is according to described even
Field mechanism position information is disposed in around the magnet of MR imaging apparatus.
In one embodiment, there is magnetic field detectors 201 multiple to be distributed in the magnetic field among MR imaging apparatus
Detecting head.Each detection of magnetic field head separately detects the magnetic field of itself position.Magnetic field detectors 201 can be based on each magnetic field
The Magnetic Field that detecting head is converged, determines main field inhomogeneities.
3D structural informations are included：The particulate size of ferromagnetic material and insulating properties material in shimming mechanism, and it is ferromagnetic
Property material and insulating properties material mutual alignment information；Relative position of the shimming mechanism positional information comprising shimming mechanism with magnet
Put.And, shimming mechanism includes ferromagnetic material and insulating properties material.
Computing unit 202 can be the terminal arbitrarily with computing capability, such as PC, smart mobile phone, flat board electricity
Brain, personal digital assistant or the computing system positioned at high in the clouds, etc..
In one embodiment, 3D printer 203, for by stereolithography mode, fused glass pellet side
Formula or selective laser sintering mode print the shimming mechanism for meeting the 3D structural informations.And, 3D printer 203 can be with profit
Shimming structure is printed with ferromagnetism and insulating materials, ferrimagnet used can be the line that metal or metallic compound are constituted
Or powder, and insulating materials used can be the plastic material line or powder easy to process such as resin.
In one embodiment, the system further includes arrangement unit 204.
The arrangement unit 204, for the shimming mechanism to be arranged in into magnetic resonance according to the shimming mechanism positional information
Around the magnet of imaging device.
In sum, in embodiments of the present invention, the main field inhomogeneities of MR imaging apparatus is detected；Calculate and mend
Repay the 3D structural informations and shimming mechanism positional information of the shimming mechanism of the main field inhomogeneities；Using 3D printing method
Print the shimming mechanism for meeting the 3D structural informations；The shimming mechanism is arranged according to the shimming mechanism positional information
Around the magnet of MR imaging apparatus.3D structural informations of the invention and shimming mechanism positional information compared to existing technology may be used
With more accurate, shimming effect also can be more preferable, is not usually required to multiple shimming.
And, in embodiments of the present invention, ferromagnetism and insulating materials in shimming mechanism arbitrarily can mix to subtract
Few vortex.Such as, ferrimagnet and Ins. ulative material can be with size (the such as various fine particles much smaller than prior art
Shape) mix, and also because the size of ferrimagnet and Ins. ulative material is smaller, ferrimagnet and Ins. ulative material exist
Distribution in shimming mechanism can also be more extensive and accurate.And by 3D automatic printing shimming mechanisms, can be notable
Reduce cost of labor and improve installation effectiveness.
The above, only presently preferred embodiments of the present invention is not intended to limit the scope of the present invention.It is all
Within the spirit and principles in the present invention, any modification, equivalent substitution and improvements made etc. should be included in protection of the invention
Within the scope of.
Claims (8)
1. a kind of method for shimming of MR imaging apparatus, it is characterised in that the method includes：
Detect the main field inhomogeneities of MR imaging apparatus；
Calculate the 3D structural informations and the positional information of shimming mechanism of the shimming mechanism of the compensation main field inhomogeneities；
The shimming mechanism for meeting the 3D structural informations is printed using 3D printing method；
The shimming mechanism is arranged in around the magnet of MR imaging apparatus according to the shimming mechanism positional information,
3D structural informations are included：The particulate size of ferromagnetic material and insulating materials in shimming mechanism, and ferromagnetic material
With the mutual alignment information of insulating materials；
And ferromagnetic material and Ins. ulative material can also arbitrarily mix to reduce vortex.
2. the method for shimming of MR imaging apparatus according to claim 1, it is characterised in that the ferromagnetic material is
Line or powder including metal or metallic compound.
3. the method for shimming of MR imaging apparatus according to claim 1, it is characterised in that the insulating properties material is
Line or powder including plastic material.
4. the method for shimming of MR imaging apparatus according to claim 3, it is characterised in that the plastic material is tree
Fat.
5. the shimming system of a kind of MR imaging apparatus, it is characterised in that the system includes that a magnetic field detectors, calculate single
Unit and a 3D printer, wherein：
The magnetic field detectors, the main field inhomogeneities for detecting MR imaging apparatus；
The computing unit, 3D structural informations and shimming for calculating the shimming mechanism of the compensation main field inhomogeneities
The positional information of mechanism；
The 3D printer, the shimming mechanism of the 3D structural informations is met for printing；
According to the positional information of the shimming mechanism, the shimming mechanism is located at around the magnet of MR imaging apparatus,
3D structural informations are included：The particulate size of ferromagnetic material and insulating materials in shimming mechanism, and ferromagnetic material
With the mutual alignment information of insulating materials；
And ferromagnetic material and Ins. ulative material can also arbitrarily mix to reduce vortex.
6. the shimming system of MR imaging apparatus according to claim 5, it is characterised in that the detection of magnetic field utensil
There are multiple detection of magnetic field heads being distributed among MR imaging apparatus.
7. the shimming system of MR imaging apparatus according to claim 5, it is characterised in that the 3D printer, uses
Meet the 3D structures in being printed by stereolithography mode, fused glass pellet mode or selective laser sintering mode
The shimming mechanism of information.
8. the shimming system of MR imaging apparatus according to claim 5, it is characterised in that further include an arrangement
Unit,
The arrangement unit, magnetic resonance imaging dress is arranged in for the positional information according to the shimming mechanism by the shimming mechanism
Around the magnet put.
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| EP3411895A4 (en) * | 2016-02-03 | 2019-09-18 | ETP Ion Detect Pty Ltd | Apparatus and methods for controlling a charged particle in a magnetic field |
| CN108535672B (en) * | 2018-04-18 | 2023-09-08 | 杭州佩伟拓超导磁体技术有限公司 | Magnetic field shimming material of magnetic resonance magnet system and manufacturing method thereof |
| CN115526046B (en) * | 2022-09-27 | 2023-06-13 | 江西嘉百乐商业管理集团有限公司 | Magnetic resonance passive shimming device and generation method, device, system and equipment thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101334455A (en) * | 2007-02-13 | 2008-12-31 | 株式会社东芝 | Magnetic resonance imaging apparatus, nuclear magnetic resonance analysis apparatus, and rack |
| CN101916640A (en) * | 2009-03-23 | 2010-12-15 | 英国西门子公司 | The apparatus and method that are used for the magnetic field shimming |
| CN102640010A (en) * | 2009-12-02 | 2012-08-15 | 纳纳利塞斯公司 | Method and apparatus for producing homogeneous magnetic fields |
| EP2510896A1 (en) * | 2011-04-15 | 2012-10-17 | Universität Bern | Container for an organ |
| CN103213281A (en) * | 2013-04-09 | 2013-07-24 | 重庆绿色智能技术研究院 | Magnetorheological-material-based 3D (Three-Dimensional) printing type rapid prototyping device and method |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060058632A1 (en) * | 2004-09-13 | 2006-03-16 | Mcburnett Doyle H | Method of medical modeling |
| US8579620B2 (en) * | 2011-03-02 | 2013-11-12 | Andy Wu | Single-action three-dimensional model printing methods |
-
2013
- 2013-08-14 CN CN201310353966.9A patent/CN104375106B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101334455A (en) * | 2007-02-13 | 2008-12-31 | 株式会社东芝 | Magnetic resonance imaging apparatus, nuclear magnetic resonance analysis apparatus, and rack |
| CN101916640A (en) * | 2009-03-23 | 2010-12-15 | 英国西门子公司 | The apparatus and method that are used for the magnetic field shimming |
| CN102640010A (en) * | 2009-12-02 | 2012-08-15 | 纳纳利塞斯公司 | Method and apparatus for producing homogeneous magnetic fields |
| EP2510896A1 (en) * | 2011-04-15 | 2012-10-17 | Universität Bern | Container for an organ |
| CN103213281A (en) * | 2013-04-09 | 2013-07-24 | 重庆绿色智能技术研究院 | Magnetorheological-material-based 3D (Three-Dimensional) printing type rapid prototyping device and method |
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