CN104353365A - Full-automatic hemodialysis membrane water overflow tester and testing method - Google Patents

Full-automatic hemodialysis membrane water overflow tester and testing method Download PDF

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Publication number
CN104353365A
CN104353365A CN201410662325.6A CN201410662325A CN104353365A CN 104353365 A CN104353365 A CN 104353365A CN 201410662325 A CN201410662325 A CN 201410662325A CN 104353365 A CN104353365 A CN 104353365A
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water
joint
pressure
haemodialyser
water tank
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CN201410662325.6A
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CN104353365B (en
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牟倡骏
代朋
徐天成
于亚楠
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Shandong Weigao Blood Purification Products Co Ltd
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Weihai Weigao Blood Purified Product Co Ltd
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Abstract

The invention discloses an automatic hemodialysis membrane water overflow tester and testing method, and relates to the hemodialysis membrane water measuring device and testing method. The tester comprises a water tank, a DC water pump, a temperature sensor, a heater, a water supply joint, a first electrically operated valve, a water supply joint, a second electrically operated valve, a water supply pressure sensor, backwater joints, a permeate joint, a backwater pressure sensor, a liquid flow sensor, a signal acquiring device, a singlechip and a signal transmitting device; a hemodialyzer or a flat sheet membrane fixing device is connected with the devices to measure the water overflow. The tester disclosed by the invention is high in automation degree, is simple and convenient for operation, saves labor, is high in measurement precision, small in error and fast in speed; the automatic hemodialysis membrane water overflow tester and the testing method are suitable for measuring the water overflow of the capillary fiber membrane or the flat sheet membrane.

Description

Fully automatic blood dialysis film water surpasses tester and method of testing
Technical field
The present invention relates to haemodialysis film water and surpass measurement mechanism and method of testing, say it is that a kind of automaticity is high in detail, measure simple to operate, the fully automatic blood dialysis film water that certainty of measurement is high surpasses tester and method of testing.
Background technology
Haemodialyser is also known as " artificial kidney ", and in dialysis procedure, blood and dislysate are in flowing in the other direction in dialyzer, and the cross-film running of solute and water is all carried out in dialyzer, and dialysis membrane is the most important part of dialyzer.An important parameter of evaluating blood dialysis membrane performance is exactly the ultrafiltration volume (water overflows) of water, and namely water makes transmembrane movement under the effect of film pressure at both sides difference, and ultrafiltration volume is directly proportional to the hydraulic pressure gradient of film both sides.In the research and development process of novel hemodialysis film, the mensuration that water overflows is as the most basic evaluation method of a kind of film properties, and the personnel that are always developed paid attention to.But how can obtain test result accurately and rapidly, improving the efficiency of research and development, is a difficult problem for all researchers institute facing.
(application number is 2011205527605 for a kind of hollow fiber film thread water flux of Chinese patent and bubble pressure integrated test electricity testing device, Authorization Notice No. is CN202366624U) disclose a kind of device testing doughnut membrane flux and aperture, this device comprises test pure water water tank, wears a pearl, the first intake valve, the first pressure test device, the second intake valve, the second pressure test device, air bleeding valve and a water replanishing device.This device adopts compressed air to be power source, and power supply is also unstable; In addition, the shortcomings such as its structure is simple, automaticity is not high, needs Artificial Control condition determination, needs manually to gather the measurement data such as pressure, flow simultaneously, there is error large, operation inconvenience.
Summary of the invention
The object of the invention is to solve above-mentioned the deficiencies in the prior art, provide a kind of simple to operate, time saving and energy saving, power source stable output, automatically gather experimental data, the fully automatic blood dialysis film water that certainty of measurement is high surpasses tester and method of testing.
The present invention's adopted technical scheme that solves the problem is:
A kind of fully automatic blood dialysis film water surpasses tester, comprise water tank and DC water pump, temperature sensor and heater is provided with in water tank, water tank bottom is connected with DC water pump water inlet by the road, DC water pump delivery port is connected with water supply joint with water tank upper by the road respectively, the pipeline that DC water pump delivery port is connected with water tank upper is provided with the first motor-driven valve, the pipeline that DC water pump delivery port is connected with water supply joint is provided with the second motor-driven valve and pressure of supply water sensor, be provided with backwater joint and permeate joint, backwater joint is communicated with water tank upper by the road, the pipeline that backwater joint is connected with water tank upper is provided with pressure of return water sensor, permeate joint is connected with permeate delivery pipe, permeate delivery pipe is provided with liquid flow sensor, temperature sensor, pressure of supply water sensor, pressure of return water sensor, liquid flow sensor are connected with single-chip microcomputer through signal pickup assembly respectively, and single-chip microcomputer is connected with heater with the first motor-driven valve, the second motor-driven valve through device for signalling.
Single-chip microcomputer described in the present invention is connected with memory.For real-time storage measurement data, be convenient to have access to analysis.
Water tank described in the present invention is built with pure water, and electrical conductivity is lower than 50 μ S/cm, and water temperature remains on 24 DEG C-26 DEG C.
Water tank described in the present invention and be provided with the manual modulation valve controlling to supply water between DC water pump.
The method of testing method that above-mentioned fully automatic blood dialysis film water surpasses tester comprises the steps:
(1) blood entry port of water supply joint with the haemodialyser that capillary fiber film is housed is connected, backwater joint is exported with the blood of haemodialyser and is connected, be connected with a dislysate mouth of haemodialyser by permeate joint, another dislysate mouth of haemodialyser is closed; Or by water supply joint, backwater joint and permeate joint respectively with the water inlet of Flat Membrane fixture of Flat Membrane, delivery port are housed export with permeate and be connected;
(2) will add the pure water of electrical conductivity lower than 50 μ S/cm in water tank, the pure water in water tank remains on 24-26 degree under the control of single-chip microcomputer, opens the first motor-driven valve below water tank, the second motor-driven valve;
(3) in the control program of single-chip microcomputer, preset the average pressure value P that haemodialyser is imported and exported 0= , connect the power supply of DC water pump, water starts to circulate in systems in which;
(3) pressure signal P collected and fluid flow rate signal L, in signal pickup assembly, are transferred in single-chip microcomputer by signal pickup assembly by the signal Real-time Collection of the fluid flow L under the relevant pressure P pressure signal P recorded with pressure sensor or liquid flow sensor recorded;
(4) pressure P imported and exported with the dialyzer collected of single-chip microcomputer enter, P go outfor foundation, the average pressure value P imported and exported with the haemodialyser preset 0for control objectives, calculate the aperture of electro-hydraulic control valve in real time, performed by the opening value Real-time Feedback calculating gained to electro-hydraulic control valve, the average pressure value that the haemodialyser described in control is imported and exported reaches P 0;
(5) according to the pressure signal P collected enter, P go outwith relevant pressure P 0under fluid flow rate signal L calculate the water of hemodialysis membrane and overflow:
A. first circulate pure water in dialyzer 15min in advance, after having circulated in advance, starts to gather the data on flows of each dialyzer in 10min;
B. by average pressure P that the haemodialyser that obtains is imported and exported 0bring formula into , the water obtained under this pressure overflows;
Wherein L be the haemodialyser that records of fluid flowmeter within the unit interval through the volume of pure water, n is the radical of capillary fiber film in dialyzer, and S is the Intimal area of single capillary fiber film;
(6) treat that signals collecting is complete, automatically close the second motor-driven valve, storing measurement result, enters step (7), otherwise, change dialyzer, repeat above-mentioned steps (3);
(7) terminate to measure, close DC water pump power supply, close first, second electro-hydraulic control valve.
Flat Membrane fixture described in the present invention comprises upper end cover and bottom end cover, upper end cover is relative with bottom end cover fastens formation test chamber, upper end cover is provided with the water inlet and delivery port that are communicated with test chamber, is embedded with millipore filter in the upper end cover below water inlet and delivery port; Bottom end cover is provided with the permeate be communicated with test chamber and exports, porous filter disc is embedded with in the bottom end cover of permeate outlet top, porous filter disc upper side is provided with stainless steel filtering net, be provided with Flat Membrane between stainless steel filtering net and millipore filter, Flat Membrane is fixed through the joint of upper end cover and bottom end cover.Described stainless steel filtering net outward flange through endless metal clip on the outer periphery.Described upper end cover and the joint of bottom end cover are provided with sealing ring, and Flat Membrane is pressed abd fixed between upper end cover and bottom end cover through sealing ring.
The invention has the advantages that: what haemodialysis film water overflowed is determined as full self mode, automaticity is high, simple to operation, saving is artificial, error is little, the water that can measure the various hemodialysis membranes comprising capillary fiber film and Flat Membrane overflows, and automatically control condition determination in real time by single-chip microcomputer and gather measurement data, certainty of measurement is high, speed is fast, can have access to determination data before at any time, the test that the water for hemodialysis membrane surpasses performance provides a kind of practical and convenient device for evaluating performance.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Fig. 2 is the structural representation of haemodialyser in prior art;
Fig. 3 is the structural representation of Flat Membrane fixture;
Fig. 4 is testing process block diagram of the present invention.
Detailed description of the invention
Fully automatic blood dialysis film water as shown in Figure 1 surpasses tester, comprise water tank 15 and DC water pump 14, temperature sensor 1 and heater 2 is provided with in water tank 15, water tank bottom is connected with DC water pump 14 water inlet by the road, DC water pump 14 delivery port is connected with water supply joint 8 with water tank upper by the road respectively, the pipeline that DC water pump delivery port is connected with water tank upper is provided with the first motor-driven valve 13, the pipeline that DC water pump delivery port is connected with water supply joint 8 is provided with the second motor-driven valve 12 and pressure of supply water sensor 10, be provided with backwater joint 16 and permeate joint 9, backwater joint 16 is communicated with water tank upper by the road, the pipeline that backwater joint 16 is connected with water tank upper is provided with pressure of return water sensor 11, permeate joint 9 is connected with permeate delivery pipe, permeate delivery pipe is provided with liquid flow sensor 7, temperature sensor, pressure of supply water sensor, pressure of return water sensor, liquid flow sensor are connected through the input port of signal pickup assembly 3 with single-chip microcomputer 5 respectively, for Real-time Collection pressure, flow and temperature signal, the output port of single-chip microcomputer 5 is connected with the control end of heater 2 with the first motor-driven valve 13, second motor-driven valve 12 through device for signalling 6, carries out real-time feedback control to them.Single-chip microcomputer 5 is connected with memory 4, for real-time storage measurement data, is convenient to have access to analysis.Described water tank is built with pure water, and electrical conductivity is lower than 50 μ S/cm, and water temperature remains on 24 DEG C-26 DEG C.The manual modulation valve controlling to supply water is provided with between water tank and DC water pump.As can be seen from Figure 1, water supply joint, backwater joint and permeate joint are in parallel is mutually provided with two, can test simultaneously, strengthen testing efficiency to two groups of hemodialysis membranes, when only using one group to measure, water supply joint, the backwater joint of another group seal.
As shown in Figure 4, above-mentioned fully automatic blood dialysis film water surpasses tester assay method and comprises the steps:
(1) blood entry port of water supply joint with the haemodialyser that capillary fiber film is housed is connected, backwater joint is exported with the blood of haemodialyser and is connected, be connected with a dislysate mouth of haemodialyser by permeate joint, another dislysate mouth of haemodialyser is closed; Or by water supply joint, backwater joint and permeate joint respectively with the water inlet of Flat Membrane fixture of Flat Membrane, delivery port are housed export with permeate and be connected;
(2) will add the pure water of electrical conductivity lower than 50 μ S/cm in water tank, the pure water in water tank remains on 24-26 degree under the control of single-chip microcomputer, opens the first motor-driven valve below water tank, the second motor-driven valve;
(3) in the control program of single-chip microcomputer, preset the average pressure value P that haemodialyser is imported and exported 0= , connect the power supply of DC water pump, water starts to circulate in systems in which;
(3) pressure signal P collected and fluid flow rate signal L, in signal pickup assembly, are transferred in single-chip microcomputer by signal pickup assembly by the signal Real-time Collection of the fluid flow L under the relevant pressure P pressure signal P recorded with pressure sensor or liquid flow sensor recorded;
(4) pressure P imported and exported with the dialyzer collected of single-chip microcomputer enter, P go outfor foundation, the average pressure value P imported and exported with the haemodialyser preset 0for control objectives, calculate the aperture of electro-hydraulic control valve in real time, performed by the opening value Real-time Feedback calculating gained to electro-hydraulic control valve, the average pressure value that the haemodialyser described in control is imported and exported reaches P 0;
(5) according to the pressure signal P collected enter, P go outwith relevant pressure P 0under fluid flow rate signal L calculate the water of hemodialysis membrane and overflow:
A. first circulate pure water in dialyzer 15min in advance, after having circulated in advance, starts to gather the data on flows of each dialyzer in 10min;
B. by average pressure P that the haemodialyser that obtains is imported and exported 0bring formula into , the water obtained under this pressure overflows;
Wherein L be the haemodialyser that records of fluid flowmeter within the unit interval through the volume of pure water, n is the radical of capillary fiber film in dialyzer, and S is the Intimal area of single capillary fiber film;
(6) treat that signals collecting is complete, automatically close the second motor-driven valve, storing measurement result, enters step (7), otherwise, change dialyzer, repeat above-mentioned steps (3);
(7) terminate to measure, close DC water pump power supply, close first, second electro-hydraulic control valve.
The structure of existing haemodialyser is as shown in Figure 2: the two ends polyurethane adhesive 26 of capillary fiber film 23 is sealed up for safekeeping in transparent shell 22, and keeps the perforate of film two ends, there is certain interval between film and film, flows for permeate; Described housing 22 is provided with annular groove, and in annular groove, inlay card has O-ring seal 21, is namely sealed by sealing circle 21 between the end cap 20,24 of dialyzer and housing 22; The end cap 20,24 of dialyzer is provided with blood access 27,28, and the housing 22 of dialyzer is provided with two through dislysate mouth 25, and during use, a dislysate mouth is connected with permeate joint, and another seals with small-sized end cap.
Flat Membrane fixture described in the present invention comprises upper end cover 29 and bottom end cover 34, upper end cover 29 fastening relative to bottom end cover 34 forms test chamber, upper end cover is provided with the water inlet 30 and delivery port 40 that are communicated with test chamber, is embedded with millipore filter 31 in the upper end cover below water inlet 30 and delivery port 40; Bottom end cover is provided with the permeate be communicated with test chamber and exports 35, porous filter disc 33 is embedded with in bottom end cover above permeate outlet 35, porous filter disc 33 upper side is provided with stainless steel filtering net 37, be provided with Flat Membrane 38 between stainless steel filtering net 37 and millipore filter 31, Flat Membrane 38 is fixed through the joint of upper end cover and bottom end cover.Described stainless steel filtering net outward flange through endless metal 32 clip on porous filter disc periphery.Described upper end cover and the joint of bottom end cover are provided with sealing ring 36, and Flat Membrane is pressed abd fixed between upper end cover and bottom end cover through sealing ring.
The invention has the advantages that: what haemodialysis film water overflowed is determined as full self mode, automaticity is high, simple to operation, saving is artificial, error is little, the water that can measure the various hemodialysis membranes comprising capillary fiber film and Flat Membrane overflows, and automatically control condition determination in real time by single-chip microcomputer and gather measurement data, certainty of measurement is high, speed is fast, can have access to determination data before at any time, the test that the water for hemodialysis membrane surpasses performance provides a kind of practical and convenient device for evaluating performance.

Claims (5)

1. a fully automatic blood dialysis film water surpasses tester, comprise water tank and DC water pump, temperature sensor and heater is provided with in water tank, water tank bottom is connected with DC water pump water inlet by the road, DC water pump delivery port is connected with water supply joint with water tank upper by the road respectively, the pipeline that DC water pump delivery port is connected with water tank upper is provided with the first motor-driven valve, the pipeline that DC water pump delivery port is connected with water supply joint is provided with the second motor-driven valve and pressure of supply water sensor, be provided with backwater joint and permeate joint, backwater joint is communicated with water tank upper by the road, the pipeline that backwater joint is connected with water tank upper is provided with pressure of return water sensor, permeate joint is connected with permeate delivery pipe, permeate delivery pipe is provided with liquid flow sensor, temperature sensor, pressure of supply water sensor, pressure of return water sensor, liquid flow sensor are connected with single-chip microcomputer through signal pickup assembly respectively, and single-chip microcomputer is connected with heater with the first motor-driven valve, the second motor-driven valve through device for signalling.
2. fully automatic blood dialysis film water according to claim 1 surpasses tester, it is characterized in that described single-chip microcomputer is connected with memory.
3. fully automatic blood dialysis film water according to claim 1 surpasses tester, and it is characterized in that described water tank is built with pure water, electrical conductivity is lower than 50 μ S/cm, and water temperature remains on 24 DEG C-26 DEG C.
4. fully automatic blood dialysis film water according to claim 1 surpasses tester, it is characterized in that being provided with the manual modulation valve controlling to supply water between described water tank and DC water pump.
5. fully automatic blood dialysis film water according to claim 1 surpasses the method for testing of tester, it is characterized in that comprising the steps:
(1) blood entry port of water supply joint with the haemodialyser that capillary fiber film is housed is connected, backwater joint is exported with the blood of haemodialyser and is connected, be connected with a dislysate mouth of haemodialyser by permeate joint, another dislysate mouth of haemodialyser is closed; Or by water supply joint, backwater joint and permeate joint respectively with the water inlet of Flat Membrane fixture of Flat Membrane, delivery port are housed export with permeate and be connected;
(2) will add the pure water of electrical conductivity lower than 50 μ S/cm in water tank, the pure water in water tank remains on 24-26 degree under the control of single-chip microcomputer, opens the first motor-driven valve below water tank, the second motor-driven valve;
(3) in the control program of single-chip microcomputer, preset the average pressure value P that haemodialyser is imported and exported 0= , connect the power supply of DC water pump, water starts to circulate in systems in which;
(3) pressure signal P collected and fluid flow rate signal L, in signal pickup assembly, are transferred in single-chip microcomputer by signal pickup assembly by the signal Real-time Collection of the fluid flow L under the relevant pressure P pressure signal P recorded with pressure sensor or liquid flow sensor recorded;
(4) pressure P imported and exported with the dialyzer collected of single-chip microcomputer enter, P go outfor foundation, the average pressure value P imported and exported with the haemodialyser preset 0for control objectives, calculate the aperture of electro-hydraulic control valve in real time, performed by the opening value Real-time Feedback calculating gained to electro-hydraulic control valve, the average pressure value that the haemodialyser described in control is imported and exported reaches P 0;
(5) according to the pressure signal P collected enter, P go outwith relevant pressure P 0under fluid flow rate signal L calculate the water of hemodialysis membrane and overflow:
A. first circulate pure water in dialyzer 15min in advance, after having circulated in advance, starts to gather the data on flows of each dialyzer in 10min;
B. by average pressure P that the haemodialyser that obtains is imported and exported 0bring formula into , the water obtained under this pressure overflows;
Wherein L be the haemodialyser that records of fluid flowmeter within the unit interval through the volume of pure water, n is the radical of capillary fiber film in dialyzer, and S is the Intimal area of single capillary fiber film;
(6) treat that signals collecting is complete, automatically close the second motor-driven valve, storing measurement result, enters step (7), otherwise, change dialyzer, repeat above-mentioned steps (3);
(7) terminate to measure, close DC water pump power supply, close first, second electro-hydraulic control valve.
CN201410662325.6A 2014-11-19 2014-11-19 Fully automatic blood dialysis film water surpasses tester and method of testing Active CN104353365B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107604453A (en) * 2017-09-28 2018-01-19 威海威高血液净化制品有限公司 A kind of film wire collection device and receipts silk method
CN108246104A (en) * 2017-12-30 2018-07-06 利穗科技(苏州)有限公司 Digitize ultrafiltration system and method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003190747A (en) * 2001-12-26 2003-07-08 Nipro Corp Leak detection method for hollow-fiber membrane module
WO2007094188A1 (en) * 2006-02-16 2007-08-23 Nikkiso Company Limited Blood purification apparatus and method of examining leakage therein
CN201930728U (en) * 2011-01-19 2011-08-17 天津泰达新水源科技开发有限公司 Online detecting device for filtering quality of hollow-fiber separating membrane
CN103418249A (en) * 2012-10-31 2013-12-04 上海理工大学 Ultrafiltration rate measurement device of hollow fiber hemodialyzer
CN204233982U (en) * 2014-11-19 2015-04-01 威海威高血液净化制品有限公司 Fully automatic blood dialysis film water surpasses tester

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003190747A (en) * 2001-12-26 2003-07-08 Nipro Corp Leak detection method for hollow-fiber membrane module
WO2007094188A1 (en) * 2006-02-16 2007-08-23 Nikkiso Company Limited Blood purification apparatus and method of examining leakage therein
CN201930728U (en) * 2011-01-19 2011-08-17 天津泰达新水源科技开发有限公司 Online detecting device for filtering quality of hollow-fiber separating membrane
CN103418249A (en) * 2012-10-31 2013-12-04 上海理工大学 Ultrafiltration rate measurement device of hollow fiber hemodialyzer
CN204233982U (en) * 2014-11-19 2015-04-01 威海威高血液净化制品有限公司 Fully automatic blood dialysis film water surpasses tester

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107604453A (en) * 2017-09-28 2018-01-19 威海威高血液净化制品有限公司 A kind of film wire collection device and receipts silk method
CN108246104A (en) * 2017-12-30 2018-07-06 利穗科技(苏州)有限公司 Digitize ultrafiltration system and method

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Address after: No.20, Xingshan Road, Weihai Torch hi tech Industrial Development Zone, Weihai City, Shandong Province, 264210

Patentee after: Shandong Weigao blood purification products Co.,Ltd.

Address before: 264209 No.20 Xingshan Road, torch hi tech Industrial Development Zone, Weihai City, Shandong Province

Patentee before: WEIHAI WEIGAO BLOOD PURIFICATION PRODUCTS Co.,Ltd.

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