CN104352911B - 一种治疗家畜呼吸道疾病的组合物及其制备方法 - Google Patents
一种治疗家畜呼吸道疾病的组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗家畜呼吸道疾病的纯中药组合物，其特征是由以下组分按重量份数混合配制而成：地龙15‑25份、甘草15‑35份、地耳草15‑45份、地骨皮15‑45份、百合20‑55份、百部25‑35份、列当15‑35份、当归15‑35份、肉桂15‑45份、朱砂10‑20份、竹叶15‑65份、元胡25‑45份。本发明的有益效果是：组方合理，制备简单，纯中药组合物无毒副作用，无药物残留、无耐药性，疗效非常显著、临床证明对治疗家畜呼吸道疾病有特效。
Description
技术领域
本发明涉及一种治疗家畜呼吸道疾病的组合物及其制备方法，属于动物医药领域，特别涉及一种专门用于治疗家畜呼吸道疾病的组合物及其制备方法。
背景技术
家畜呼吸道疾病主要是由支原体、细菌、病毒等引起的一种常见流行性疾病，临床表现以感染家畜呼吸啰音、咳嗽、流鼻液为特征；病理变化主要表现在气管及支气管有浆液或黏液性渗出物，气囊炎、心包炎、肝周炎等。该病对家畜养殖业危害极大。
目前，治疗该病最常用的是各种抗菌药物，如土霉素、氯霉素、青霉素、链霉素、喹诺酮类等，由于抗菌药物普遍具有毒副作用较强和易产生耐药性等缺点，疗效显著下降，且药物残留在动物体内，其肉质达不到无公害要求，影响畜产品的出口和人们的健康。而抗病毒药农业部已经严令禁止使用。中药由于粉碎粒径大，生物利用度低，起效较慢，效果不是很理想。
因此研发一种有效治疗家畜呼吸道疾病的药物是该领域科研技术人员急待解决的新课题之一。
发明内容
本发明的目的在于克服上述不足之处，提供一种组方合理、制备简单，纯中药组合物无毒副作用、无药物残留、无耐药性，有效治疗家畜呼吸道疾病的组合物及其制备方法。
为实现上述目的本发明所采用的实施方式如下：一种治疗家畜呼吸道疾病的组合物，其特征是由以下组分按重量份数混合配制而成：地龙15-25份、甘草15-35份、地耳草15-45份、地骨皮15-45份、百合20-55份、百部25-35份、列当15-35份、当归15-35份、肉桂15-45份、朱砂10-20份、竹叶15-65份、元胡25-45份。
所述各种组分优选配比量为：地龙20份、甘草25份、地耳草30份、地骨皮30份、百合35份、百部30份、列当25份、当归25份、肉桂30份、朱砂15份、竹叶40份、元胡35份。
一种治疗家畜呼吸道疾病的组合物的制备方法，其特征是按如下步骤进行：
(1)将组方中的各味中药分别进行超微粉碎后过700目筛；
(2)按重量称取地龙15-25份、甘草15-35份、地耳草15-45份、地骨皮15-45份、百合20-55份、百部25-35份，混合5-10分钟至均匀；
(3)按重量称取列当15-35份、当归15-35份、肉桂15-45份、朱砂10-20份、竹叶15-65份、元胡25-45份，混合5-10分钟至均匀；
(4)合并上述(2)、(3)步骤制得的组合物，继续混合10-15分钟至均匀即成。
各组分的药物特性如下：
地龙：咸、寒，归肝、脾、膀胱经，具有清热定惊、通络、平喘、利尿的功能；主治热病痉搐、拘挛痹痛、气喘、水肿等。
甘草：甘、平，归肺、心、脾经，具有补脾益气、祛痰止咳、和中缓急、解毒、调和诸药、缓解药物毒性、烈性的功能；主治脾胃虚弱、咳喘、中毒等。
地耳草：苦、辛、平，归肝、肺经，具有清热利湿、散瘀消肿的功能；主治湿热黄疸、跌扑损伤、疮痈等。
地骨皮：甘、寒，归肺、肝、肾经，具有凉血退热、清肺降火的功能；主治阴虚血热、肺热咳喘等。
百合：甘、寒，归心、肺经，具有养阴润肺、清心安神的功能；主治心神不宁、阴虚久咳、肺燥咳喘等。
百部：甘、苦、温，归肺经，具有清肺止咳、杀虫去疥的功能；主治肺热、肺痈、虫积腹痛、蛲虫、体虱、癣疥等。
列当：微苦、甘、温，归心、胃经，具有补肾壮阳、强筋骨、润肠通便的功能；主治阳痿、滑精、腰肢无力、肠燥便秘等。
当归：甘、辛、温，归肝、心、脾经，具有补血养血、活血止痛、润燥通便的功能；主治血虚劳伤、血瘀疼痛、臃肿疮疡、肠燥便秘、胎产诸病等。
肉桂：甘、辛、热，归肝、肾、脾、心经，具有温中散寒、温肾壮阳、行水的功能；主治肾阳不足、脾胃寒、冷痛、水肿、泄泻、风寒湿痹、肠痉挛等。
朱砂：甘、微寒，归心经，具有清心镇惊、安神、解毒的功能；主治心热风邪、躁动不安、热病癫痫、脑黄、疮疡肿毒等。
竹叶：甘、淡、寒，归心、胃、小肠经，具有清热、利尿的功能；主治心热舌疮、尿短赤、尿血等。
元胡：苦、辛、温，归心、肝经，具有活血行气、止痛的功能；主治胸腹诸痛、跌打损伤、血瘀气滞、泻痢腹痛等。
以上诸味药物按照药物理论配伍组合，针对家畜呼吸道疾病的致病因素和病理变化，发挥标本兼治的作用。
本发明的有益效果是：组方合理，制备简单，分步混合更加均匀；纯中药组合物无毒副作用、无药物残留、无耐药性。临床应用证明对治疗家畜呼吸道疾病有特效。
具体实施方式
以下结合较佳实施例，对依据本发明提供的具体实施方式详述如下：
实施例1
一种治疗家畜呼吸道疾病的组合物及其制备方法：其特征是按如下步骤进行：(每份按10g计)
(1)将组方中的各味中药分别进行超微粉碎后过700目筛；
(2)按重量称取地龙150份、甘草150份、地耳草150份、地骨皮150份、百合200份、百部250份，混合5-10分钟至均匀；
(3)按重量称取列当150份、当归150份、肉桂150份、朱砂100份、竹叶150份、元胡250份，混合5-10分钟至均匀；
(4)合并上述(2)、(3)步骤制得的组合物，继续混合10-15分钟至均匀即成。
实施例2
一种治疗家畜呼吸道疾病的组合物及其制备方法：其特征是按如下步骤进行：(每份按10g计)
(1)将组方中的各味中药分别进行超微粉碎后过700目筛；
(2)按重量称取地龙200份、甘草250份、地耳草300份、地骨皮300份、百合350份、百部300份，混合5-10分钟至均匀；
(3)按重量称取列当250份、当归250份、肉桂300份、朱砂150份、竹叶400份、元胡350份，混合5-10分钟至均匀；
(4)合并上述(2)、(3)步骤制得的组合物，继续混合10-15分钟至均匀即成。
实施例3
一种治疗家畜呼吸道疾病的组合物及其制备方法：其特征是按如下步骤进行：(每份按10g计)
(1)将组方中的各味中药分别进行超微粉碎后过700目筛；
(2)按重量称取地龙250份、甘草350份、地耳草450份、地骨皮450份、百合550份、百部350份，混合5-10分钟至均匀；
(3)按重量称取列当350份、当归350份、肉桂450份、朱砂200份、竹叶650份、元胡450份，混合5-10分钟至均匀；
(4)合并上述(2)、(3)步骤制得的组合物，继续混合10-15分钟至均匀即成。
临床试验：
临床实验动物选用100-120日龄、体重在40kg-50kg，实验室确诊为由病原微生物支原体引起的家畜呼吸道病的患病猪。将患病猪隔离单独饲养，饲喂全价饲料，并随机分为3组，每组30头，3组饲养环境完全相同，实验时间共进行5天；空白对照组不做任何处理，药物对照组用所对照药物按其说明书使用治疗；本发明组合物组将本发明产品(本发明实施例2所制得的组合物)喂食患病猪，日服用量为：每100克本发明组合物拌料200公斤饲喂，每日1-2次；口服后通过胃肠道吸收达到治疗疾病的目的。计算方法：死亡率＝死亡动物数/试验动物数×100％，治愈率＝治愈动物数/试验动物数×100％。下表是实验结束时的结果。
疗效评定标准：
治愈：精神正常，采食饮水正常，粪便正常，健康活泼，实验室检测未见病原微生物猪支原体等。
结束时有症状：临床症状没有改善甚至加重。
表是本发明与其它药物治疗猪呼吸道病的情况对比：
| 编号 | 组别 | 死亡率％ | 治愈率％ | 结束时有症状率％ |
| I | 空白对照组 | 10 | 56.7 | 33.3 |
| II | 镇喘散组 | 3.3 | 80.0 | 16.7 |
| III | 本发明组合物组 | 0 | 93.3 | 6.7 |
本次临床结果经统计分析，本发明组合物组与镇喘散组在治愈率方面相比差异极显著(P＜0.01)。
安全性试验：
选取70日龄健康猪10头，依照本发明实施例2所制中药组合物推荐剂量的10倍拌料饲喂5天，用药期间，健康猪没有任何不良或异常行为表现，采食饮水正常，体重增加和空白对照组(即健康不给药组)相比差异不显著。
上述参照实施例对该治疗家畜呼吸道疾病的组合物及其制备方法进行的详细描述，是说明性的而不是限定性的，可按照所限定范围列举出若干个实施例，因此在不脱离本发明总体构思下的变化和修改，应属本发明的保护范围之内。
Claims (3)
1.一种治疗家畜呼吸道疾病的纯中药组合物，其特征是由以下组分按重量份数混合配制而成：
地龙15-25份、甘草15-35份、地耳草15-45份、地骨皮15-45份、百合20-55份、百部25-35份、列当15-35份、当归15-35份、肉桂15-45份、朱砂10-20份、竹叶15-65份、元胡25-45份。
2.根据权利要求1所述的治疗家畜呼吸道疾病的组合物，其特征是由以下组分按重量份数混合配制而成：
地龙20份、甘草25份、地耳草30份、地骨皮30份、百合35份、百部30份、列当25份、当归25份、肉桂30份、朱砂15份、竹叶40份、元胡35份。
3.一种根据权利要求1或2所述的治疗家畜呼吸道疾病的组合物的制备方法，其特征是按如下步骤进行：
(1)将组方中的各味中药分别进行超微粉碎后过700目筛；
(2)按重量称取地龙15-25份、甘草15-35份、地耳草15-45份、地骨皮15-45份、百合20-55份、百部25-35份，混合5-10分钟至均匀；
(3)按重量称取列当15-35份、当归15-35份、肉桂15-45份、朱砂10-20份、竹叶15-65份、元胡25-45份，混合5-10分钟至均匀；
(4)合并上述(2)、(3)步骤制得的组合物，继续混合10-15分钟至均匀即成。
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