CN104352285B - A kind of design and fabrication method of individuation 3D printing planting body - Google Patents
A kind of design and fabrication method of individuation 3D printing planting body Download PDFInfo
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- CN104352285B CN104352285B CN201410691945.2A CN201410691945A CN104352285B CN 104352285 B CN104352285 B CN 104352285B CN 201410691945 A CN201410691945 A CN 201410691945A CN 104352285 B CN104352285 B CN 104352285B
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- support body
- web support
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Abstract
The invention discloses a kind of design and fabrication method of individuation 3D printing planting body, the aperture averaging of porous web support body is divided into n1 grade, porosity is equally divided into n2 grade, thickness is equally divided into n3 grade, n1 × n2 × n3 corresponding elastic modelling quantity of porous web support body is divided into n4 grade, so that the density of correspondence n4 kind sclerotin；The shooting of preoperative jawbone quantitive CT is carried out to patient, average flexible bone modulus E is calculated using three-dimensional reconstruction software and empirical equation, the thickness most thick one of porous web support body is selected in the planting body of the elastic modelling quantity close range；3D printing is carried out to planting body, head and body portion are integrally formed.The classification of the aperture of porous web support body of the present invention, porosity and thickness is set, and planting body is reached different size of elastic modelling quantity, is adapted to the crowd of different bone mineral.
Description
Technical field
The present invention relates to a kind of medical embedded biomaterial, more particularly to a kind of individuation 3D printing planting body sets
Meter and preparation method.
Background technology
The history in material of the titanium or titanium alloy material as planting body existing more than 30 years, but the elastic modelling quantity of titanium
(110GPa) differs larger with the elastic modelling quantity (3~30GPa of cortex of bone, 0.5~3GPa of cancellous bone) of people's jawbone, can cause stress
Shadowing effect, causes bone information, so as to cause planting body to loosen, plantation failure.Jawbone is in itself according to position different bone mineral
Difference, maxilla is based on cancellous bone, and the cortex bone of mandibular is thicker, therefore plantation position is different, the elastic modelling quantity of bone environment
Also it is different.And have some patients due to diseases such as periodontosis, osteoporosis, diabetes, tumours, its Grafting Cancellous Bone Bolt density
Differ bigger with titanium less than the elastic modelling quantity of normal person, thus jawbone, Planting risk increases therewith.
The introducing of loose structure can reduce the overall elastic modelling quantity of material, moreover it is possible to bone tissue is grown into hole, strengthen bone knot
Close.Alkali is carried out to porous outer layer in Chinese patent 200610136835.5 " a kind of porous titanium implant body and preparation method "
Heat treatment, bionical deposited hydroxyl apatite.
In recent years, 3D printing technique is widely used in porous biomaterial research field, and 3D printing energy precise control is more
The micro-structural of hole biomaterial, can produce multiplet any combination integration, because each micro-structural all possesses specific
Mechanical performance, thus planting body mechanical performance can be able to it is any regulation reach individuation customization requirement.
The content of the invention
It is an object of the invention to overcome the deficiencies in the prior art, there is provided a kind of design of individuation 3D printing planting body
With preparation method, be adapted to various bone density crowds.
The present invention is achieved by the following technical solutions, and preparation method of the invention is comprised the following steps：
(1) aperture averaging of porous web support body is divided into n1 grade, porosity is equally divided into n2 grade, and thickness is average
It is divided into n3 grade, the porous web support body of different pore size, porosity and thickness is combined into n1 × n2 × n3 dual extension-compression modulus
Porous web support body；
(2) n1 × n2 × n3 corresponding elastic modelling quantity of porous web support body is divided into n4 grade, matches n4 kind bone densities；
(3) shooting of preoperative jawbone quantitive CT is carried out to patient, Three-dimensional Gravity is carried out to edentulous area according to CT scan data
Build, selection uses the rectangle region of planting body specification by the cross section CT scan image at edentulous area midpoint on cross-sectional image
Domain representation, and obtain the mean CT-number GV of rectangular area；
(4) mean bone density ρ is calculated according to mean CT-number GV
ρ=1017*GV-13.4；
Average flexible bone modulus E is calculated according to mean bone density ρ
E=5925* ρ -388.8；
(5) according in E values size correspondence selecting step (2) with the immediate one kind of E, then in the elastic modelling quantity scope phase
The thickness most thick one of porous web support body is selected near planting body；
(6) many abortive haul support bodys selected according to step (5), 3D printing is carried out to planting body, and head and body portion are integrally formed.
The aperture of the porous web support body is 50~800 μm, and 10~90%, thickness is 0.5~1.5mm to porosity.
In the step (1), n1=4, respectively 50~200 μm, 200~400 μm, 400~600 μm, 600~800 μm；
N2=8, respectively 10~20%, 20~30%, 30~40%, 40~50%, 50~60%, 60~70%, 70~80%, 80
~90%；N3=5, respectively 0.5~0.7mm, 0.7~0.9mm, 0.9~1.1mm, 1.1~1.3mm, 1.3~1.5mm.
The printing planting body that the present invention makes, including integrally formed head and body portion, the head are provided with for connecting
The groove of foundation pile, the outer surface in the body portion is provided with screw thread, and the body portion includes solid and porous web support body, porous web support body
It is covered on the outer surface of solid.
Used as one of preferred embodiment of the invention, the porous web support body is porous web grating texture.
The present invention has advantages below compared to existing technology：The aperture of porous web support body of the present invention, porosity and thickness point
Level is set, and planting body is reached different size of elastic modelling quantity, is adapted to the crowd of different bone mineral；Solid knot inside planting body
Structure ensure that the bulk strength of planting body, and porous outer surface grid structure reduces the overall elastic modelling quantity of planting body, by bone
Tissue grows into hole, strengthens synosteosis；Planting body overall structure is produced by the step of 3D printing technique one and completed, and makes interior solid knot
Structure and porous outer surface grid structure are rigidly combined, process is simple, low cost.
Brief description of the drawings
Fig. 1 is structural representation of the invention.
Specific embodiment
Embodiments of the invention are elaborated below, the present embodiment is carried out under premised on technical solution of the present invention
Implement, give detailed implementation method and specific operating process, but protection scope of the present invention is not limited to following implementations
Example.
As shown in figure 1, the printing planting body of the present embodiment, including integrally formed head 1 and body portion 2, head 1 is provided with use
In the groove 11 of connection foundation pile, the surface of body portion 2 is provided with screw thread, and body portion 2 includes solid 21 and porous web support body 22, porous rack
Body 22 is covered on the outer surface of solid 21.Porous web support body 22 is porous web grating texture.Head 1 is to wear gum part, body
Portion 2 is synosteosis part.
The present embodiment is comprised the following steps：
(1) aperture of porous web support body 22 is 50~800 μm, and 10~90%, thickness is 0.5~1.5mm to porosity, will
The aperture averaging of porous web support body 22 is divided into 4 grades, respectively 50~200 μm, 200~400 μm, 400~600 μm, 600~
800μm；Porosity is equally divided into 8 grades, respectively 10~20%, 20~30%, 30~40%, 40~50%, 50~
60%th, 60~70%, 70~80%, 80~90%；Thickness is equally divided into 5 grades, and respectively 0.5~0.7mm, 0.7~
0.9mm, 0.9~1.1mm, 1.1~1.3mm, 1.3~1.5mm；
The porous web support body 22 of different pore size, porosity and thickness is combined into 4 × 8 × 5=160 dual extension-compression modulus
Porous web support body 22；
(2) 160 corresponding elastic modelling quantity of porous web support body 22 are divided into 10 grades, and the scope of elastic modelling quantity is 0
~100GPa, respectively 0~10GPa, 10~20GPa, 20~30GPa, 30~40GPa, 40~50GPa, 50~60GPa, 60
~70GPa, 70~80GPa, 80~90GPa, 90~100GPa；
(3) shooting of preoperative jawbone quantitive CT is carried out to patient, using professional software such as Simplant, Nobelguide,
Implant3D etc. carries out three-dimensional reconstruction to case CT scan data, selects by the cross section CT scan figure at edentulous area midpoint
Picture, the position of planting body is designed using above-mentioned software on cross-sectional image, is represented with the rectangular area of planting body specification, such as
4.1mm × 10mm, obtains the mean CT-number GV of rectangular area；
(4) mean bone density ρ (g/cm are calculated using mean CT-number3), ρ=1017*GV-13.4, using mean bone density ρ
Calculate average flexible bone modulus E (MPa), E=5925* ρ -388.8；
(5) according in E values size correspondence selecting step (2) with the immediate one kind of E, then in the elastic modelling quantity scope phase
The thickness most thick one of porous web support body is selected near planting body；
(6) many abortive haul support bodys selected according to step (5), 3D printing is carried out to planting body, and head and body portion are integrally formed；
(7) planting body can be clinical conventional size such as 4.1mm*10mm, can be clinical conventional variously-shaped bag
Include cone, cylindricality, improvement cone etc..
Particular embodiments described above, has been carried out further in detail to the purpose of the present invention, technical scheme and beneficial effect
Describe in detail bright, should be understood that and the foregoing is only specific embodiment of the invention, be not intended to limit the invention, it is all
Within the spirit and principles in the present invention, any modification, equivalent substitution and improvements done etc., should be included in guarantor of the invention
Within the scope of shield.
Claims (3)
1. a kind of preparation method of individuation 3D printing planting body, it is characterised in that comprise the following steps：
(1) aperture averaging of porous web support body is divided into n1 grade, porosity is equally divided into n2 grade, and thickness is equally divided into
N3 grade, the porous web support body of different pore size, porosity and thickness is combined into many of the dual extension-compression modulus of n1 × n2 × n3
Hole pattern support body；
(2) n1 × n2 × n3 corresponding elastic modelling quantity of porous web support body is divided into n4 grade, matches n4 kind bone densities；
(3) shooting of preoperative jawbone quantitive CT is carried out to patient, three-dimensional reconstruction is carried out to edentulous area according to CT scan data, selected
Select by the cross section CT scan image at edentulous area midpoint, with the rectangular area table of planting body specification on cross-sectional image
Show, and obtain the mean CT-number GV of rectangular area；
(4) mean bone density ρ is calculated according to mean CT-number GV
ρ=1017*GV-13.4；
Average flexible bone modulus E is calculated according to mean bone density ρ
E=5925* ρ -388.8；
(5) according in E values size correspondence selecting step (2) with the immediate one kind of E, then in the elastic modelling quantity close range
The thickness most thick one of porous web support body is selected in planting body；
(6) the porous web support body selected according to step (5), 3D printing is carried out to planting body, and head and body portion are integrally formed；
The planting body includes head and body portion, and body portion includes solid and porous web support body, and porous web support body is covered in solid
On the outer surface of body.
2. the preparation method of a kind of individuation 3D printing planting body according to claim 1, it is characterised in that described porous
The aperture of rack body is 50~800 μm, and 10~90%, thickness is 0.5~1.5mm to porosity.
3. a kind of preparation method of individuation 3D printing planting body according to claim 2, it is characterised in that the step
(1) in, n1=4, respectively 50~200 μm, 200~400 μm, 400~600 μm, 600~800 μm；N2=8, respectively 10~
20%th, 20~30%, 30~40%, 40~50%, 50~60%, 60~70%, 70~80%, 80~90%；N3=5, point
Wei not 0.5~0.7mm, 0.7~0.9mm, 0.9~1.1mm, 1.1~1.3mm, 1.3~1.5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410691945.2A CN104352285B (en) | 2014-11-25 | 2014-11-25 | A kind of design and fabrication method of individuation 3D printing planting body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410691945.2A CN104352285B (en) | 2014-11-25 | 2014-11-25 | A kind of design and fabrication method of individuation 3D printing planting body |
Publications (2)
| Publication Number | Publication Date |
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| CN104352285A CN104352285A (en) | 2015-02-18 |
| CN104352285B true CN104352285B (en) | 2017-07-07 |
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| CN201410691945.2A Expired - Fee Related CN104352285B (en) | 2014-11-25 | 2014-11-25 | A kind of design and fabrication method of individuation 3D printing planting body |
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| CN104729904B (en) * | 2015-03-31 | 2017-07-28 | 中国石油大学(华东) | A kind of complicated rock core preparation method based on CT scan and 3D printing |
| CN105030355A (en) * | 2015-09-08 | 2015-11-11 | 航天海鹰(哈尔滨)钛业有限公司 | Implant for false tooth |
| PL237370B1 (en) * | 2016-04-28 | 2021-04-06 | Frydrychewicz Artur Af Praktyka Stomatologiczna | Bionic implants and methods for producing them |
| CN106333753B (en) * | 2016-08-23 | 2019-07-02 | 天津医科大学口腔医院 | The dental implant and preparation method thereof of individuation bionic |
| CN106037965A (en) * | 2016-08-23 | 2016-10-26 | 天津医科大学口腔医院 | Individualized biomimetic dental implant and manufacture method thereof |
| CN106580494B (en) * | 2016-12-15 | 2019-06-04 | 宁波创导三维医疗科技有限公司 | A kind of segmentation stephanoporate implant and its design and production method |
| CN107260342A (en) * | 2017-06-30 | 2017-10-20 | 青岛大学附属医院 | A kind of 3D printing bionic tooth implant and preparation method thereof |
| CN107832529A (en) * | 2017-11-13 | 2018-03-23 | 广州市健齿生物科技有限公司 | A kind of loose structure implant design system |
| CN107908862A (en) * | 2017-11-13 | 2018-04-13 | 广州市健齿生物科技有限公司 | A kind of standard series tooth implant Parameterized Design System |
| CN107789079A (en) * | 2017-12-01 | 2018-03-13 | 西北有色金属研究院 | A kind of porous helicitic texture tooth implant implant |
| CN108452371B (en) * | 2018-03-08 | 2020-12-25 | 上海交通大学医学院附属仁济医院 | Preparation method of oral implant |
| CN109938854A (en) * | 2019-04-03 | 2019-06-28 | 西安交通大学 | A kind of bionical implantation material, artificial tooth root and preparation method thereof |
| CN112402065A (en) * | 2019-08-23 | 2021-02-26 | 北京智塑健康科技有限公司 | Manufacturing method, system and device of fusion device and storage medium thereof |
| CN112137719B (en) * | 2020-09-16 | 2021-07-06 | 中国科学院力学研究所 | Manufacturing method of 3D printing simulation bone based on CT image |
| CN114631916A (en) * | 2022-03-01 | 2022-06-17 | 博志生物科技(深圳)有限公司 | Intervertebral fusion cage, manufacturing method and system thereof, intelligent manufacturing equipment and medium |
| CN114795598B (en) * | 2022-04-20 | 2023-06-23 | 北京大学第三医院（北京大学第三临床医学院） | Preparation method of interbody fusion cage |
| CN116327452A (en) * | 2023-05-30 | 2023-06-27 | 吉林大学 | Multi-element coupling bionic cushion block for knee joint defect and manufacturing method thereof |
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| CN104352285A (en) | 2015-02-18 |
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