CN104345096B - Method for rapidly detecting polyols in cosmetic - Google Patents
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- CN104345096B CN104345096B CN201310325769.6A CN201310325769A CN104345096B CN 104345096 B CN104345096 B CN 104345096B CN 201310325769 A CN201310325769 A CN 201310325769A CN 104345096 B CN104345096 B CN 104345096B
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 73
- 238000000034 method Methods 0.000 title claims abstract description 18
- 229920005862 polyol Polymers 0.000 title abstract 3
- 150000003077 polyols Chemical class 0.000 title abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000012086 standard solution Substances 0.000 claims abstract description 20
- 239000012488 sample solution Substances 0.000 claims abstract description 17
- 239000000126 substance Substances 0.000 claims abstract description 13
- 239000000706 filtrate Substances 0.000 claims abstract description 5
- 238000001507 sample dispersion Methods 0.000 claims abstract description 5
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 4
- 239000000523 sample Substances 0.000 claims description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- 150000005846 sugar alcohols Polymers 0.000 claims description 24
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 21
- 150000001298 alcohols Chemical class 0.000 claims description 18
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 16
- 239000000243 solution Substances 0.000 claims description 14
- 239000007789 gas Substances 0.000 claims description 13
- 229940058015 1,3-butylene glycol Drugs 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 8
- 229960005082 etohexadiol Drugs 0.000 claims description 8
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 7
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 6
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 4
- 238000010813 internal standard method Methods 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 239000012159 carrier gas Substances 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims description 2
- 238000010790 dilution Methods 0.000 claims description 2
- 239000012895 dilution Substances 0.000 claims description 2
- 230000014759 maintenance of location Effects 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 230000004044 response Effects 0.000 claims description 2
- 238000004445 quantitative analysis Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 2
- 238000002137 ultrasound extraction Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 description 16
- 239000006071 cream Substances 0.000 description 15
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 10
- 230000001815 facial effect Effects 0.000 description 10
- 239000000080 wetting agent Substances 0.000 description 7
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000004817 gas chromatography Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 208000001738 Nervous System Trauma Diseases 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013098 chemical test method Methods 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010812 external standard method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000028412 nervous system injury Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention provides a method for rapidly detecting polyols in a cosmetic. The method includes the following steps: using an internal standard solution and a standard substance to prepare a mixed standard solution with different concentrations; preparing a cosmetic sample dispersion, carrying ultrasonic extraction, filtering, and placing the obtained filtrate put in a closed container to obtain a cosmetic sample solution for later use; respectively carrying out gas chromatographic analysis on the mixed standard solution and the cosmetic sample solution; and using an internal standard technology to draw a standard in order to obtain the concentrations and the content of alcohol components. The method has the advantages of simple operation, high efficiency and reliable result, and can be used to simultaneously quantitatively detect 8 polyols in the cosmetic.
Description
Technical field
The invention belongs to cosmetic composition analysis detection field, the quick inspection of polyalcohols in more particularly, to a kind of cosmetics
Survey method.
Background technology
In cosmetics, chemical composition is varied, and alcohols is widely used raw material in cosmetics industry, wetting agent and steady
Determine agent.In cosmetics, " polyhydric alcohol " class wetting agent mainly includes butanediol, Polyethylene Glycol, propylene glycol, ethylene glycol, glycerol etc..Though
So polyalcohols wetting agent has good moistening effect, but is excessively used some polyhydric alcohol and has potential danger.Research shows,
The propylene glycol of high concentration and ethylene glycol expose, and can interefere seriously with health.Low dose of or micro propylene glycol and being used for of butanediol
Be typically considered safe in cosmetic and food, but be as propylene glycol and butanediol accumulate in the body also can cause lung,
Heart and central nervous system injury.2009 2 months, European Union formally issued in new cosmetics instruction and explicitly points out in cosmetics
Diethylene glycol mass fraction must not exceed 0.1%.
Because different alcohols structural properties are not quite similar, the sample substrate being additionally present of is also complicated various, therefore, existing mark
For different alcohols wetting agents in standard, use the detection meanss in different State of cosmetics different.At present, detect alcohol
The standard species of class is various, and the experiment condition being related to is also different.The alcohols wetting agent species that prior art is directed to detection compares
Single, tend not to the multiple common alcoholic of one-time detection.Detect all of alcohols, then need repeated detection, cause detection week
Phase lengthens, and reduces efficiency.Therefore, existing detection method cannot meet the detection demand for alcohols in cosmetics for the market.
Content of the invention
It is an object of the invention to：There is provided a kind of method for quick of polyalcohols in cosmetics it is intended to meet market
Detection demand for alcohols in cosmetics.
The object of the present invention is achieved like this：
In a kind of cosmetics, the method for quick of polyalcohols, comprises the following steps：
Make the mixed standard solution of variable concentrations with inner mark solution and standard substance；
Prepared by cosmetic sample solution：Preparing cosmetics sample dispersion liquid, supersound extraction, filtration, filtrate is placed in airtight
In container, obtain cosmetic sample solution, stand-by；
Gas chromatographic analysiss are carried out respectively to described mixed standard solution and cosmetic sample solution；
Draw standard curve with internal standard method and draw the concentration of alcohol component and alcohol content in sample solution.
The present invention rapidly and accurately can detect the polyhydric alcohol of 1-8 kind and its quantitation in cosmetics simultaneously, also has behaviour
Make the advantages of easy, anti-matrix interference, reliable results, and this method also extend to many in similar system (as food)
First alcohol and other low boiling alcohols (ethanol, isopropanol, hexadecanol, octadecanol etc.).
Brief description
Fig. 1 is the chromatogram of alcohols standard substance；
Fig. 2 is the chromatogram of cosmetic sample A (eye cream)；
Fig. 3 is the chromatogram of cosmetic sample B (facial cream)；
Fig. 4 is the chromatogram of cosmetic sample C (cosmetic water)；
Fig. 5 is the chromatogram of cosmetic sample D (facial cream).
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, below in conjunction with drawings and Examples, right
The present invention is further elaborated.It should be appreciated that specific embodiment described herein is only in order to explain the present invention, and
It is not used in the restriction present invention.
The various chemical raw materials that the present invention refers to, instrument and equipment all can be commercially available by existing approach.Following realities
Apply the method in example, if no special instructions, be conventional method.
Embodiment 1：The selection of testing conditions
Gas chromatograph：Agilent 7890 type gas chromatograph, joins flame ionization ditector (FID)；
Chromatographic column：HP-INNOWax, specification is：30m × 0.32mm × 0.25 μm or other fixing phase are Polyethylene Glycol
Capillary chromatographic column；Analytical balance：Precision 0.1mg；
Solvent：Methanol (chromatographically pure)；
Internal standard substance：N-butyl alcohol (analysis pure) or other any have stable response under this chromatographic condition, and polynary with to be measured
The different alcohols of alcohol retention；
Standard substance：Ethanol, isopropanol, 1,2-PD, 1,3-PD, 1,3 butylene glycol, 1,2- pentanediol, 1,2- are own
Glycol, 1,2- ethohexadiol, dipropylene glycol, glycerol, hexadecanol, octadecanol；
Cosmetic sample：A (eye cream), B (facial cream), C (cosmetic water), D (facial cream).
Embodiment 2：The preparation of standard solution
Above-mentioned internal standard substance and solvent are configured to the inner mark solution of 0.1-50mg/mL (preferably 10mg/mL).
Accurately weigh each about 50mg of above-mentioned various standard substance in same 25mL volumetric flask, carved with methanol constant volume to 25mL
Degree, the mixed standard solution of prepared 2mg/mL.
By described mixed standard solution stepwise dilution, and add inner mark solution in the mixed mark solution of every grade of concentration, finally
It is configured to the standard solution (concentration range 0.005-2mg/mL) of 2-5 level Concentraton gradient.
Embodiment 3：The preparation of sample solution
Accurately weigh above-mentioned various cosmetic sample respectively in volumetric flask, after adding inner mark solution, with methanol constant volume extremely
Volumetric flask scale, is configured to the dispersion liquid in 2-50mg/mL for the sample concentration；After supersound extraction (5-30min), with dried and clean
Defecator filters, and filtrate is sample solution, is placed in be measured in the airtight container of cleaning.
Embodiment 4：Polyhydric alcohol in solution is detected by gas chromatography
Gas chromatograph quantitative analyses condition：Take split sampling mode (split ratio 10: 1)；Injector temperature 180-220
DEG C (preferably 220 DEG C)；Carrier gas is High Purity Nitrogen, flow velocity 1.0mL/min；Sample size 0.1-2 μ L (preferably 1 μ L)；Heating schedule：Initially
Temperature 40-70 DEG C (preferably 60 DEG C), is raised to 220-240 DEG C (preferably with 2-15 DEG C/min (preferably 10 DEG C/min) after keeping 2min
230 DEG C), keep 5-15min (preferably 10min)；250-300 DEG C of detector temperature (preferably 280 DEG C).
Series standard solution and sample solution are detected respectively by gas chromatograph, draws standard curve with internal standard method and obtain
Obtain the concentration of the various alcohol component containing in sample solution, and calculate the content of the every kind of alcohol in sample by formula (1)：
Formula (1)
Wherein：C0：The concentration (mg/mL) of sample dispersion liquid；
C：The concentration (mg/mL) of this alcohol in sample solution
Embodiment 5：The range of linearity of alcohols and its in cosmetics content corresponding relation
In conjunction with the chromatogram of the alcohols standard substance shown in Fig. 1, the range of linearity of each alcohols standard substance can be obtained and its making up
The corresponding relation of content in product, as shown in table 1：
Table 1
Due to content in cosmetics for the polyhydric alcohol wetting agent generally 0.2-10% about, the change of preparation about 10mg/mL
The detection that cosmetic sample dispersion liquid can meet polyhydric alcohol wetting agent requires.
Embodiment 6：Polyhydric alcohol detection in cosmetic sample A (eye cream)
The gas chromatogram of cosmetic sample A (eye cream) is as shown in Fig. 2 make mirror for convenience of comparison by mixed standard solution collection of illustrative plates
As processing, record in cosmetic sample A (eye cream) and contain 1,3 butylene glycol, the content being computed 1,3 butylene glycol is as shown in table 2：
Table 2
| The polyhydric alcohol being added in sample A | Addition (%) | Measured value (%) |
| 1,3 butylene glycol | 5.0 | 5.2 |
Embodiment 7：Polyhydric alcohol detection in cosmetic sample B (facial cream)
The gas chromatogram of cosmetic sample B (facial cream) is as shown in figure 3, make mirror for convenience of comparison by mixed standard solution collection of illustrative plates
As processing, record and in cosmetic sample B (facial cream), contain 1,3-PD and glycerol, be computed containing of 1,3-PD and glycerol
Amount is as shown in table 3：
Table 3
| The polyhydric alcohol that sample B is added | Addition (%) | Measured value (%) |
| 1,3-PD | 10 | 10.3 |
| Glycerol | 7.6 | 7.5 |
Embodiment 8：Polyhydric alcohol detection in cosmetic sample C (cosmetic water)
The gas chromatogram of cosmetic sample C (cosmetic water) is as shown in figure 4, do mixed standard solution collection of illustrative plates for convenience of comparison
Mirror image processing, records and contains 1,3-PD, 1,2- pentanediol, 1,2- ethohexadiol and double third in cosmetic sample C (cosmetic water)
Glycol, be computed 1,3-PD, 1,2- pentanediol, 1,2- ethohexadiol and dipropylene glycol content as shown in table 4：
Table 4
| The polyhydric alcohol that sample C is added | Addition (%) | Measured value (%) |
| 1,3-PD | 6.5 | 6.5 |
| 1,2- pentanediol | 3.0 | 3.0 |
| 1,2- ethohexadiol | 0.2 | 0.22 |
| Dipropylene glycol | 2.0 | 1.9 |
Embodiment 9：Polyhydric alcohol detection in cosmetic sample D (facial cream)
The gas chromatogram of cosmetic sample D (facial cream) is as shown in figure 5, make mirror for convenience of comparison by mixed standard solution collection of illustrative plates
As processing, record and in cosmetic sample D (facial cream), contain 1,2-PD, 1,3 butylene glycol, 1,2- pentanediol, 1,3- the third two
Alcohol, dipropylene glycol, 1,2- hexanediol, 1,2- ethohexadiol and glycerol, are computed 1,2-PD, 1,3 butylene glycol, 1,2- penta 2
Alcohol, 1,3-PD, dipropylene glycol, 1,2- hexanediol, 1,2- ethohexadiol and glycerol content as shown in table 5：
Table 5
| The polyhydric alcohol that sample D is added | Addition (%) | Measured value (%) |
| 1,2-PD | 8 | 7.2 |
| 1,3 butylene glycol | 5 | 4.5 |
| 1,2- pentanediol | 3 | 2.7 |
| 1,3-PD | 6 | 5.8 |
| Dipropylene glycol | 4 | 3.8 |
| 1,2- hexanediol | 0.2 | 0.22 |
| 1,2- ethohexadiol | 0.1 | 0.13 |
| Glycerol | 4 | 4.3 |
From upper table and accompanying drawing, detection method that the present invention provides can detect 1-8 kind polyhydric alcohol and its accurately simultaneously
Content, and chromatographic peak favorable reproducibility, sample pre-treatments easy and simple to handle it is easy to carry out.
Alcohols detection method in existing cosmetics, mainly in the majority with colorimetry, spectrophotography and gas chromatography, and adopt
The result measuring alcohol species in cosmetics with gas chromatography is more quick and sensitive, and GC-External Standard method measures alcohol content
Shi Wufa avoids the volatilization of alcohols to cause quantitative deviation, for avoid this error is produced to testing result, the present invention takes gas phase
Chromatograph internal standard method is analyzed to alcohols.
《Cosmetics health specification》First in cosmetics is defined in (2007 editions) Part III " health chemical testing method "
The assay method of alcohol content, the method is gas chromatography.The method measures Determination of methanol in cosmetics content and is only applicable to containing ethanol
Or the cosmetics of isopropanol, and sample method is divided into two kinds of the cosmetics containing propellant with without propellant, sampling method
Complexity, samples limited by sample, and cosmetic sample of the present invention sampling is simple, not limited by cosmetic composition or dosage form etc..
When cosmetic sample is processed, prior art requires and carries out multiple dissolving, extraction, mistake to cosmetic sample
Filter, still further comprises in some prior arts and carries out heating to cosmetic sample solution and the step such as volatilize, concentrate, these all can
Lead to the loss of sample, make testing result inaccurate, and due to usually containing thickening agent, emulsifying agent, powder etc. in cosmetics
Material, the extracting solution of cosmetics, especially denseer extracting solution is very easy to when filtering block the duct of filter membrane, leads to filter and is stranded
Difficulty, or even sucking filtration dozens of minutes can only leach less than half, and prior art usually requires that leaching all extracting solution just can be carried out
The analysis of next step.And the present invention has broken the prejudice that prior art is prepared for cosmetic sample solution, only to cosmetics sample
Product are once dissolved, extracted and are filtered, and only need to leach a small amount of filtrate (0.5mL about enough) and can carry out subsequent analysis, filter
The amount of liquid enough carries out normal gas chromatographic sample introduction, not only so that operation is more easy, improves efficiency, and decreases
The loss of sample, the more preferable testing result simultaneously also obtaining, the type of the polyhydric alcohol that not only can simultaneously detect is more, to every kind of
The quantitation of alcohol is also more accurate.Mutually for purposes of the invention, prior art not only complex steps, time-consuming many but also easily lose sample
Cause to detect inaccurate.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Any modification, equivalent and improvement made within god and principle etc., should be included within the scope of the present invention.
Claims (2)
1. in a kind of cosmetics the method for quick of polyalcohols it is characterised in that the method comprises the following steps：
Make the mixed standard solution of variable concentrations with inner mark solution and standard substance；
Wherein：Accurately take the ethanol of same components, isopropanol, 1,2-PD, 1,3-PD, 1,3 butylene glycol, 1,2- penta
Glycol, 1,2- hexanediol, 1,2- ethohexadiol, dipropylene glycol, glycerol, hexadecanol and octadecanol standard substance in same volumetric flask,
With methanol constant volume to volumetric flask scale, obtain mixed standard solution, the concentration range of described mixed standard solution is 0.005-2mg/
mL；
By mixed standard solution stepwise dilution, and it is separately added into inner mark solution, be configured to the mixed standard solution of variable concentrations；
Prepared by cosmetic sample solution：Accurately weigh cosmetic sample in volumetric flask, after adding inner mark solution, use methanol constant volume
To scale, it is configured to the sample dispersion liquid that concentration range is 2-50mg/mL, after supersound extraction 5-30min, with the mistake of dried and clean
Filter device filters, and filtrate is placed in the airtight container of cleaning, obtains cosmetic sample solution, stand-by；
Described mixed standard solution and cosmetic sample solution are carried out respectively with gas chromatographic analysiss, described gas chromatograph is quantitative
Analysis condition be：
Chromatographic column：HP-INNOWax, 30m × 0.32mm × 0.25 μm or other fixing phase are the capillary chromatography of Polyethylene Glycol
Post；180-220 DEG C of injector temperature；Carrier gas is High Purity Nitrogen, flow velocity 1.0mL/min；Sample size 0.1-2 μ L；Heating schedule：Initially
Temperature 40-70 DEG C, is raised to 220-240 DEG C with 2-15 DEG C/min after keeping 2min, keeps 5-15min；Detector temperature 250-300
℃；
Draw standard curve with internal standard method and draw the concentration of alcohol component and alcohol content in sample solution.
2. in cosmetics as claimed in claim 1 the method for quick of polyalcohols it is characterised in that described inner mark solution is
With n-butyl alcohol or other any have stable response under chromatographic condition, and the alcohols different from polyhydric alcohol retention to be measured is internal standard
Thing, methanol is formulated for solvent.
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| CN106645536B (en) * | 2017-01-09 | 2018-10-23 | 宁波职业技术学院 | Low molecular weight PEG dressing agent content assaying methods |
| CN107255685A (en) * | 2017-08-01 | 2017-10-17 | 厦门鉴科检测技术有限公司 | The high performance liquid chromatography of ultraviolet absorber in a kind of detection cosmetics |
| CN107831131A (en) * | 2017-11-13 | 2018-03-23 | 龙蟒佰利联集团股份有限公司 | A kind of assay method of the polyalcohols organic surface treatment covering amount of titanium dioxide |
| CN108037231A (en) * | 2017-12-13 | 2018-05-15 | 中国检验检疫科学研究院 | Method that is a kind of while measuring 8 kinds of gylcol ether compounds in cosmetics |
| CN110954632A (en) * | 2019-12-30 | 2020-04-03 | 广州艾蓓生物科技有限公司 | Method for determining content of 1,2-hexanediol in cosmetics |
| CN112505164A (en) * | 2020-07-10 | 2021-03-16 | 中检科（北京）测试技术有限公司 | Method for determining propylene glycol, butylene glycol, hexylene glycol, lauryl alcohol, glycerol, stearyl alcohol and cetyl alcohol in cosmetics |
| CN112268964A (en) * | 2020-09-28 | 2021-01-26 | 江苏集萃新型药物制剂技术研究所有限公司 | Method for measuring content of hexadecanol and octadecanol in medicinal preparation |
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| CN102955011A (en) * | 2012-11-08 | 2013-03-06 | 黑龙江省轻工科学研究院 | Gas chromatography detection method of ethylene glycol, diethylene glycol and menthol in toothpaste |
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| CN102955011A (en) * | 2012-11-08 | 2013-03-06 | 黑龙江省轻工科学研究院 | Gas chromatography detection method of ethylene glycol, diethylene glycol and menthol in toothpaste |
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