CN104338179A - Self-enhanced bone plate of absorbable coating and manufacturing method of self-enhanced bone plate - Google Patents
Self-enhanced bone plate of absorbable coating and manufacturing method of self-enhanced bone plate Download PDFInfo
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- CN104338179A CN104338179A CN201310345384.6A CN201310345384A CN104338179A CN 104338179 A CN104338179 A CN 104338179A CN 201310345384 A CN201310345384 A CN 201310345384A CN 104338179 A CN104338179 A CN 104338179A
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Abstract
The invention provides a self-enhanced bone plate of a macromolecular coating capable of meeting relatively high clinical requirements, and a manufacturing method of the self-enhanced bone plate. The self-enhanced bone plate of the coating, which is provided by the invention, comprises two parts, namely a copolymerizing material and a porous calcium phosphate ceramic coating; and calcium phosphate is coated in the self-enhanced bone plate according to a certain ratio. The coating thickness and the degradation time are controlled by controlling the ratio and the soaking time of synthetic materials, and thus the self-enhanced bone plate has the advantages of being good in maneuverability, biodegradability and biocompatibility, non-toxic, free of an injury to tissue and beneficial to growth of skeletons and degradation synchronization of polymers; inflammations are reduced; and the self-enhanced bone plate can be applied to a plurality of surgical bone repairing operations of military surgery, maxillofacial surgery and the like, and is suitable for implementation and popularization.
Description
Technical field
The present invention relates to a kind of Absorbable rod coating self-reinforcing hone lamella manufacture method.
Background technology
The built-in implant great majority of clinical treatment maxillofacial fracture and Cranial defect are metal objects, and as titanium alloy sheet, corrosion resistant plate etc., it is fixing strong, and after can ensureing operation, early function exercise curative effect is reliable.But its major defect has: 1, need after bone healing again to perform the operation taken out and likely cause secondary fracture.Increase patient economically, psychological burden.2, the elastic modelling quantity of metal implant is far above natural bone, therefore, in the process of knitting, produces stress-shielding effect, and causes osteoporosis and osteanabrosis, the mechanical performance of impact healing bone.
3,loosening and deteriorating of metal object causes inflammatory reaction, and surrounding soft tissue and osseous tissue are produced to chronic stimulation, cause molten bone, Gu Jia, cause clinical symptoms.
Summary of the invention
The present invention is a kind of Absorbable rod coating self-reinforcing hone lamella and manufacture method thereof, it is characterized in that the polymer provided is one or more in polylactide (PLA), PGA (PGA), PLGA, poly-meso lactic acid (PDLLA); Coating self-reinforcing hone lamella comprises copolymeric material, porous calcium phosphate ceramic coating two part.Can be used for multiple neurosurgery, the surgery bone repair operations such as decorative sursery, suitable promotion and implementation are also promoted.
Coating substance is coated porous calcium phosphate ceramic; Hone lamella is polylactide, and precursor copolymer is poly-meso lactic acid (PDLLA); Solution is acetone, dichloromethane, chloroform, oxolane.Coated porous calcium phosphate ceramic solubility is 5%-20%, and aperture is 4-6um; Calcium phosphate according to a certain percentage coating in self-reinforcing hone lamella, control by controlling the ratio of synthetic material and soak time the thickness of coating, degradation time thus have that operability is good, degradable, good biocompatibility, nontoxic, to the growth organizing not damaged to be conducive to skeleton, and the degraded synchronization of polymer reduce the advantages such as the generation of inflammation; Hone lamella is polylactide viscosity-average molecular weight is that 40-80 ten thousand, by a certain percentage copolymerization form; Support copolymer is 10-80 ten thousand for gathering meso lactic acid (PDLLA) viscosity-average molecular weight, and coat very thin one deck is about 0.05-0.1 wall thickness.Two-sided orientation bending modulus is there is between 5.2-7.5 in the different die cavity of special pearl mould more than material glass temperature, bending strength reaches 215 ± 20 MPa: mold pressing reaches material internal generation directional orientation and forms netted shape repeatedly, product have room temperature plastotype exempt from hot bending exempt from soak, the features such as uniform intensity.
Adopt the method cambium of above design to achieve interface cohesion, can also grow in hole, and there is the lactic acid that effect control product is implanted in inflammation and depolymerization produces, reduce symptom of aching.
embodiment:
Coating self-reinforcing hone lamella provided by the present invention comprises copolymeric material, porous calcium phosphate ceramic coating two part.Calcium phosphate according to a certain percentage coating in self-reinforcing hone lamella.Be conducive to the growth of skeleton, and the degraded synchronization of polymer reduce the generation of inflammation.Coating composition gathers meso lactic acid (PDLLA), porous calcium phosphate ceramic.
Embodiment
1, different mould bases is plastified into after absorbable material copolymerization by Minitype twin-screw extrusion machine;
2, adopt the different die cavity of special pearl mould two-sided orientation bending modulus to occur more than material glass temperature between 5.2-7.5, bending strength reaches 215 ± 20 MPa: mold pressing reaches material internal generation directional orientation and formed netted repeatedly;
3, finishing impression equipment is adopted to make product make certain hone lamella shape according to clinical demand;
4, a certain amount of PDLLA is dissolved in acetone, is mixed with the PDLLA solution that mass fraction is 4%-10% respectively;
5,5%-30% calcium phosphate is added in coating, by hone lamella soak time 3-10S;
6, drying at room temperature, can be applied one deck calcium phosphate thin film uniformly.
Claims (4)
1. the present invention is a kind of Absorbable rod coating self-reinforcing hone lamella and manufacture method thereof, it is characterized in that the polymer provided is one or more in polylactide (PLA), PGA (PGA), PLGA, poly-meso lactic acid (PDLLA); Coating substance is coated porous calcium phosphate ceramic; Hone lamella is polylactide, and precursor copolymer is poly-meso lactic acid (PDLLA); Solution is acetone, dichloromethane, chloroform, oxolane.
2. according to claim 1, coated porous calcium phosphate ceramic solubility is 5%-20%, and aperture is 4-6um; Calcium phosphate according to a certain percentage coating, in self-reinforcing hone lamella, is conducive to the growth of skeleton and the degraded synchronization of polymer and reduces the generation of inflammation; Hone lamella is polylactide viscosity-average molecular weight is that 40-80 ten thousand, by a certain percentage copolymerization form; Support copolymer is 10-80 ten thousand for gathering meso lactic acid (PDLLA) viscosity-average molecular weight, and coat very thin one deck is about 0.05-0.1 wall thickness.
3. there is two-sided orientation bending modulus between 5.2-7.5 in the different die cavity of special pearl mould more than material glass temperature, bending strength reaches 215 ± 20 MPa: mold pressing reaches material internal generation directional orientation and forms netted shape repeatedly, product have room temperature plastotype exempt from hot bending exempt from soak, the features such as uniform intensity.
4. adopt the method cambium of above design to achieve interface cohesion, can also grow in hole, and there is the lactic acid that effect control product is implanted in inflammation and depolymerization produces, reduce symptom of aching.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310345384.6A CN104338179A (en) | 2013-08-09 | 2013-08-09 | Self-enhanced bone plate of absorbable coating and manufacturing method of self-enhanced bone plate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310345384.6A CN104338179A (en) | 2013-08-09 | 2013-08-09 | Self-enhanced bone plate of absorbable coating and manufacturing method of self-enhanced bone plate |
Publications (1)
| Publication Number | Publication Date |
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| CN104338179A true CN104338179A (en) | 2015-02-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310345384.6A Pending CN104338179A (en) | 2013-08-09 | 2013-08-09 | Self-enhanced bone plate of absorbable coating and manufacturing method of self-enhanced bone plate |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825219A (en) * | 2015-05-03 | 2015-08-12 | 刘乐 | Bone plate for minimally invasive surgery |
| CN106620889A (en) * | 2017-02-16 | 2017-05-10 | 鼎科医疗技术（苏州）有限公司 | Medical device implanted in vivo and manufacturing method of medical device |
| CN106983551A (en) * | 2017-05-12 | 2017-07-28 | 国家康复辅具研究中心 | Porous complex bone plate of rigidity gradient change and preparation method thereof |
| CN110251279A (en) * | 2019-07-17 | 2019-09-20 | 上海纳米技术及应用国家工程研究中心有限公司 | A kind of preparation method of the 3D printing PLGA Invasive lumbar fusion device of calcium phosphate bone cement coating |
| CN110585490A (en) * | 2019-09-16 | 2019-12-20 | 上理检测技术(上海)有限公司 | Micro-motion compression steel plate |
Citations (4)
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|---|---|---|---|---|
| EP1405648A1 (en) * | 2001-06-20 | 2004-04-07 | Taki Chemical Co., Ltd. | Method for coating substrates for living body tissue |
| CN1644561A (en) * | 2004-01-20 | 2005-07-27 | Seoul大学校 | Method for producing polymeric sol of calcium phosphate compound and method for coating the same on a metal implant |
| CN101934095A (en) * | 2010-08-31 | 2011-01-05 | 赵亮 | Injectable strengthened phosphate lime/hydrogel microcapsule tissue engineering bone as well as preparation method and application thereof |
| CN102188749A (en) * | 2010-03-10 | 2011-09-21 | 中国科学院上海硅酸盐研究所 | 3D porous bracket with mesoporous biological glass coating and preparation method thereof |
-
2013
- 2013-08-09 CN CN201310345384.6A patent/CN104338179A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1405648A1 (en) * | 2001-06-20 | 2004-04-07 | Taki Chemical Co., Ltd. | Method for coating substrates for living body tissue |
| CN1644561A (en) * | 2004-01-20 | 2005-07-27 | Seoul大学校 | Method for producing polymeric sol of calcium phosphate compound and method for coating the same on a metal implant |
| CN102188749A (en) * | 2010-03-10 | 2011-09-21 | 中国科学院上海硅酸盐研究所 | 3D porous bracket with mesoporous biological glass coating and preparation method thereof |
| CN101934095A (en) * | 2010-08-31 | 2011-01-05 | 赵亮 | Injectable strengthened phosphate lime/hydrogel microcapsule tissue engineering bone as well as preparation method and application thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825219A (en) * | 2015-05-03 | 2015-08-12 | 刘乐 | Bone plate for minimally invasive surgery |
| CN106620889A (en) * | 2017-02-16 | 2017-05-10 | 鼎科医疗技术（苏州）有限公司 | Medical device implanted in vivo and manufacturing method of medical device |
| CN106983551A (en) * | 2017-05-12 | 2017-07-28 | 国家康复辅具研究中心 | Porous complex bone plate of rigidity gradient change and preparation method thereof |
| CN110251279A (en) * | 2019-07-17 | 2019-09-20 | 上海纳米技术及应用国家工程研究中心有限公司 | A kind of preparation method of the 3D printing PLGA Invasive lumbar fusion device of calcium phosphate bone cement coating |
| CN110585490A (en) * | 2019-09-16 | 2019-12-20 | 上理检测技术(上海)有限公司 | Micro-motion compression steel plate |
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Application publication date: 20150211 |