CN104305506A - Method for microencapsulating lutein - Google Patents
Method for microencapsulating lutein Download PDFInfo
- Publication number
- CN104305506A CN104305506A CN201410552078.4A CN201410552078A CN104305506A CN 104305506 A CN104305506 A CN 104305506A CN 201410552078 A CN201410552078 A CN 201410552078A CN 104305506 A CN104305506 A CN 104305506A
- Authority
- CN
- China
- Prior art keywords
- lutein
- emulsifying
- capsule method
- xanthin
- micro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention relates to a method for microencapsulating lutein, belonging to the field of food additives and a preparation method thereof. The method comprises the steps of firstly, dissolving gelatin and saccharose into water, then mixing lutein, oil, an antioxidant and an emulgator and preheating, instantly dissolving at a high temperature, emulsifying, homogenizing and spray drying, gathering the powder, sieving and obtaining the finished product. According to the method, the lutein is prevented from being dissolved at a high temperature for long time to have isomerism so as to cause the lowered bioavailability and difficulty in eliminating the solvent by a solvent method, residual solvent is avoided, the product is more stable, and the method is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of method of microencapsulation, belong to food additives and preparation method thereof field.
Background technology
Lutein (Lutein) is a kind of oxygen containing carotenoid; extensively be present in banana, Kiwi berry, corn and marigold; there is different physiological roles; anti-oxidant, eliminate free radical, anticancer, reduce the incidence of disease of cardiovascular disease and vision protection etc.; especially, in prevention cataract of old people and age-related macular degeneration etc., paid close attention to widely.Lutein is a kind of containing oxygen carotenoid, and relative molecular weight is 568.88, containing multiple conjugated double bond structures.Due to the existence of ethylene linkage, in theory easily isomery.Water insoluble, be slightly soluble in vegetable oil, in aliphatic and aromatic hydrocarbon, have medium dissolubility, be soluble in chloroform etc.Due to its many double bond structures, make its unstable chemcial property, under Yi Guang, heat, oxygen and acid condition, oxidation Decomposition occurs.
Due to these character of lutein, this makes them in production and processing and application, there is significant limitation.Limited dissolubility and the hypersensitivity to oxidation, hinder the direct use of thick product in food and feed dyeing of synthesizing and obtaining, because the material of coarse crystallization form only can obtain poor absorption and produce poor Color.For increasing tinctorial yield and increasing absorbability and bioavailability, the particle diameter of active material must be reduced to below l0 micron, what even have reaches nanoscale, because the painted effect of lutein and bioavailability are directly related with its particle diameter in media as well and dispersiveness.The feature that permeability is high according to the solubility of carotenoid is low, the means only by reducing carotenoid particle diameter reach and strengthen painted and sorbefacient object.
Summary of the invention
The invention provides a kind of Xanthin micro-capsule method, be intended to the Three Difficult Issues that the stability of solution high-content lutein product, isomery and high liposoluble difficulty absorb.
Xanthin micro-capsule method of the present invention, first by gelatin, sucrose dissolved in water, then by lutein, oil, antioxidant and emulsifying agent mixing pre-heating temperature elevation, then TRANSIENT HIGH TEMPERATURE dissolve, emulsifying homogeneous is spraying dry again, receive powder, sieve and finished product.
Preferably, pre-heating temperature elevation comprises: be suspended in oil phase by matrix such as lutein crystal, antioxidant, emulsifying agents, is incubated and stirs 15min at 80 ~ 90 DEG C.
Or more preferably, TRANSIENT HIGH TEMPERATURE is dissolved and is comprised: mixed liquor to be delivered to coil pipe regulating frequency under the effect of peristaltic pump and to make it be warming up to 120 ~ 140 DEG C at 15 ~ 25s by coil pipe.
Further preferably, emulsification comprises: under the effect of high-shearing dispersion emulsifying machine, xanthophyll-oil solution is added mixing and emulsifying in aqueous phase.
More preferably, homogeneous comprises: under high pressure homogenizer effect, homogeneous is prepared into the nanoscale aqueous solution for twice.
Still more preferably, spraying dry comprises and first carries out heat spray, then carries out cold spray.
Of the present invention meeting the tendency avoids the long-time high-temperature digestion of lutein and isomery declined bioavailability of oral administration and solvent process solvent and is difficult to remove, the defects such as product dissolvent residual, and makes product more stable, is applicable to suitability for industrialized production.
Detailed description of the invention
Embodiment one:
1, first by gelatin, sucrose dissolved in water.
2, the matrix such as lutein crystal, antioxidant, emulsifying agent are suspended in oil phase, are incubated and stir 15min at 80 ~ 90 DEG C.
3, mixed liquor being delivered to coil pipe regulating frequency under the effect of peristaltic pump makes it be warming up to 120 ~ 140 DEG C at 15 ~ 25s by coil pipe.
4, under the effect of high-shearing dispersion emulsifying machine, xanthophyll-oil solution is added mixing and emulsifying in aqueous phase.
5, under high pressure homogenizer effect, homogeneous is prepared into the nanoscale aqueous solution for twice.
6, the aqueous solution is first carried out heat spray (once embedding): be traditional drying process with atomizing, LS EAT be about 170 DEG C, leaving air temp is in the thermal current of about 80 DEG C, moisture flash evapn is taken away by thermal current, is dried to powder.
7, cold spray (secondary embedding) is then carried out: i.e. spray condensation method seasoning, by in the dried starch of LS below 35 DEG C, droplet surface adsorbs one deck starch and condensation shaping (again embedding), finally sieve, collect granularity and carry out drying at 30 ~ 120 object particulates.
8, Product Quality Evaluation
Product sensory index outward appearance, particle diameter, instant capacity (20 points), the hardness of tablet and fineness (15 points), product stability (30 points), product compressing tablet application stability (35 points) adopts the scoring of overall target 100 points system.
Claims (6)
1. Xanthin micro-capsule method, it is characterized in that first by gelatin, sucrose dissolved in water, then by lutein, oil, antioxidant and emulsifying agent mixing pre-heating temperature elevation, then TRANSIENT HIGH TEMPERATURE dissolve, emulsifying homogeneous is spraying dry again, receive powder, sieve and finished product.
2. Xanthin micro-capsule method as claimed in claim 1, is characterized in that pre-heating temperature elevation comprises: be suspended in oil phase by matrix such as lutein crystal, antioxidant, emulsifying agents, is incubated and stirs 15min at 80 ~ 90 DEG C.
3. Xanthin micro-capsule method as claimed in claim 1 or 2, is characterized in that TRANSIENT HIGH TEMPERATURE is dissolved and comprise: mixed liquor is delivered to coil pipe regulating frequency under the effect of peristaltic pump and makes it be warming up to 120 ~ 140 DEG C at 15 ~ 25s by coil pipe.
4. Xanthin micro-capsule method as claimed in claim 1, is characterized in that emulsification comprises: under the effect of high-shearing dispersion emulsifying machine, xanthophyll-oil solution is added mixing and emulsifying in aqueous phase.
5. Xanthin micro-capsule method as claimed in claim 1, is characterized in that homogeneous comprises: homogeneous is prepared into the nanoscale aqueous solution for twice under high pressure homogenizer effect.
6. Xanthin micro-capsule method as claimed in claim 1, is characterized in that spraying dry comprises and first carries out heat spray, then carry out cold spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410552078.4A CN104305506A (en) | 2014-10-17 | 2014-10-17 | Method for microencapsulating lutein |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410552078.4A CN104305506A (en) | 2014-10-17 | 2014-10-17 | Method for microencapsulating lutein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104305506A true CN104305506A (en) | 2015-01-28 |
Family
ID=52360941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410552078.4A Pending CN104305506A (en) | 2014-10-17 | 2014-10-17 | Method for microencapsulating lutein |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104305506A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663082A (en) * | 2016-01-21 | 2016-06-15 | 江苏怀仁生物科技有限公司 | High-inoxidizability lutein microcapsules and preparation method thereof |
| CN106690271A (en) * | 2017-01-11 | 2017-05-24 | 华南理工大学 | Preparation method of nano emulsion for improving bioavailability of xanthophyll |
-
2014
- 2014-10-17 CN CN201410552078.4A patent/CN104305506A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663082A (en) * | 2016-01-21 | 2016-06-15 | 江苏怀仁生物科技有限公司 | High-inoxidizability lutein microcapsules and preparation method thereof |
| CN106690271A (en) * | 2017-01-11 | 2017-05-24 | 华南理工大学 | Preparation method of nano emulsion for improving bioavailability of xanthophyll |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Hu et al. | Preparation, characterization, and in vitro release investigation of lutein/zein nanoparticles via solution enhanced dispersion by supercritical fluids | |
| JP6141529B2 (en) | Process for producing oil-dispersible carotenoid formulations | |
| CN103330213B (en) | Tea polyphenol liposoluble microcapsules and preparation method thereof | |
| US9173818B2 (en) | Method for preparing stable-type vitamin A microcapsules continuously | |
| CN100580028C (en) | Method for making powdery water-dispersion capsicum red pigment | |
| CN101297691B (en) | Preparation of stable water-soluble carotenoid dry powder | |
| US11278856B2 (en) | Lutein microcapsule formulation and preparation method thereof | |
| CN101549273B (en) | Method of preparing nano-dispersed high-all-trans-carotenoid microcapsules | |
| CN106344510B (en) | The industrialized preparing process of lycopene microemulsion | |
| CN101921495B (en) | Method for preparing lutein oleoresin microcapsule | |
| CN101921496A (en) | Method for preparing capsanthin microcapsule | |
| KR20190126830A (en) | Fat-soluble nutrient microcapsules and preparation method thereof | |
| CN103549157B (en) | Scold the preparation method of water type vitamin microcapsule | |
| CN107712543B (en) | Anti-flocculation curcumin microcapsule, preparation method and application thereof | |
| NO337378B1 (en) | Process for preparing an oily carotenoid solution | |
| JPH0366615A (en) | Manufacture of new colloid dispersion carotinoid preparation | |
| JP2000186224A (en) | Preparation of finely ground, powder carotenoid preparation | |
| JP2002543263A (en) | Xanthophyll stable aqueous dispersion and stable dry powder dispersible in water, and its production and use | |
| CN101803741A (en) | Method for preparing nano vitamin E water dispersing powder preparation by using supergravity method | |
| CN102773052B (en) | Method for preparing cold-water-dispersible carotenoid micro-capsule product | |
| WO2019109346A1 (en) | Lycopene micro-capsule powder and preparation method therefor | |
| CN102919857A (en) | Edible calcium carbonate microspheres and preparation method thereof | |
| CN101263891B (en) | Method for making lutein extract microcapsule | |
| CN104305506A (en) | Method for microencapsulating lutein | |
| CN113575945B (en) | Preparation method of nanoscale all-trans carotenoid dry powder |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150128 |
|
| WD01 | Invention patent application deemed withdrawn after publication |