CN104288728B - A kind of Chinese medicine for treating diarrhea-type irritability syndrome - Google Patents
A kind of Chinese medicine for treating diarrhea-type irritability syndrome Download PDFInfo
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- CN104288728B CN104288728B CN201410540501.9A CN201410540501A CN104288728B CN 104288728 B CN104288728 B CN 104288728B CN 201410540501 A CN201410540501 A CN 201410540501A CN 104288728 B CN104288728 B CN 104288728B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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Abstract
The present invention relates to the Chinese medicine for the treatment of diarrhea-type irritability syndrome, it can effectively solve the problems, such as to treat the medication of diarrhea-type irritability syndrome, its technical scheme solved is, by weight meter：1 10 parts of catechu, 1 12 parts of corydalis tuber, 0.5 6 parts of charred RADIX ET RHIZOMA RHEI, 1 12 parts of granatum, 1 10 parts of baked ginger charcoal are made, and catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, granatum and baked ginger charcoal are mixed, the fine powder of 100 mesh sieves was ground into altogether, sterilization, loading capsule, scientific formula of the present invention is reasonable, abundant raw material, easily production, the effect of stagnant, promoting blood circulation and stopping pain, relieving diarrhea with astringents being led with middle benefit gas, it is convenient to take effective for treatment diarrhea-type irritability syndrome, effect is good, there is actual clinical value.
Description
Technical field
The present invention relates to medicine, particularly a kind of Chinese medicine for treating diarrhea-type irritability syndrome.
Background technology
IBS（Irritable bowel syndrome, IBS）It is one group including abdominal distension, bowl evacuation habit to change
The clinical syndrome of the performance such as change and stool exception, abdominal distension, persistently exists or recurrent exerbation, on inspection, exclusion can draw
The organic disease of these symptoms is played, this disease is a kind of biological-psychology-social illness, belongs to gastrointestinal dysfunction disease.It has
There are stomachache, abdominal distension, bowl evacuation habit to change and the stool clinical syndrome such as paramophia or Mucous Stool.Symptoms last is present or interval
Breaking-out, but lack the definite foundation such as morphology and laboratory abnormalities change.
The report of IBS precise prevalences is also lacked at present, about between 10-20%.In the world except India is common with male
Outside, overwhelming majority of countries is all that women is more than male, and the ratio between men and women is about 1：2.This sick Juvenile-onset rate is higher, first after 50 years old
Secondary hair patient is rare.
IBS is one of clinically most commonly seen gastrointestinal dysfunction, accounts for the half or so of chronic diarrhea patient, but right
Its understanding is also far from enough, though on the one hand it is that a kind of intestinal movement can be disorderly, laboratory record to motility disorder with facing
Bed performance is not fully consistent, and on the other hand it is not a kind of independent disease, but one kind can be betided under various states
The syndrome behaved like.
IBS is reported by Powell earliest, afterwards once uses a variety of terms, such as nerve colon, spastic colon, colon
Allergy, neurogenic colitis, spastic colitis, mucous colitis etc., these names are not comprehensive enough and accurate, and IBS is
Currently used most suitable and accurately diagnose term, it emphasizes that this illness has irritable gastrointestinal motility disorders, is a kind of
Syndrome rather than single disease.
Although IBS can show as serious stomachache and abdominal discomfort, do not cause other chronic or fatal diseases,
Such as IBD, tumour etc. does not interfere with the life-span more.Intestinal irritable syndrome is a kind of common disease of digestive system, the disease
Incidence of disease women is higher than male, especially in the majority with white collar, and the love sport people incidence of disease is seldom.It is broadly divided into diarrhea-type, just
Secret two kinds of type.Diarrhea irritable bowel syndrome then shows as dilute, one day defecation more than three times of defecating, and sometimes, oneself is not controlled,
Influence is normal to live, works, learning and healthy.IBS is clinical to be divided into constipation type, diarrhoea according to RomeⅢdiagnostic criteria
Type, 4 partings of mixed type and prepattern, Yao Xin etc. result of study, which is shown, shines RomeⅢdiagnostic criteria, and diarrhea type irritable bowel is invited
It is most common, 2/3 is accounted for, so water content is then the important evidence of IBS partings in excrement.At present, though there is treatment diarrhea-type intestines easy
The multi-medicament of bowel syndrome, such as Western medicine imodium, seroxat, Deanxit or Chinese patent drug, but for various reasons, its using and
Effect is simultaneously unsatisfactory, therefore, and the improvement and innovation on treatment diarrhea-type irritability syndrome medicine are imperative.
The content of the invention
For above-mentioned situation, to overcome the defect of prior art, the purpose of the present invention is just to provide one kind and treats diarrhea-type
The Chinese medicine of IBS, can effectively solve the problems, such as to treat the medication of diarrhea-type irritability syndrome.
The technical scheme that the present invention is solved is, by weight meter：1-10 parts of catechu, 1-12 parts of corydalis tuber, charred RADIX ET RHIZOMA RHEI 0.5-6
Part, 1-12 parts of granatum, 1-10 parts of baked ginger charcoal are made, and wherein charred RADIX ET RHIZOMA RHEI is to mix rhubarb tablets with rice vinegar thoroughly, stews to moisten to saturating, puts stir-fry
In container, heated with slow fire, take out and dry after fried dry, weed out chip；Baked ginger charcoal is that the sand for taking cleaning puts iron pan
Interior, heating puts into baked ginger when frying to sliding profit, fries to foaming heave with high heat, and appearance is taken out when being in burnt brown, weeds out sand and ash
Bits spreading for cooling, catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, granatum and baked ginger charcoal are mixed, the fine powder of 100 mesh sieves was ground into altogether, is sterilized,
Loading capsule.
Scientific formula of the present invention rationally, abundant raw material, easily production, with middle benefit gas lead stagnant, promoting blood circulation and stopping pain, relieving diarrhea with astringents work(
Effect, effective for treatment diarrhea-type irritability syndrome, convenient to take, effect is good, there is actual clinical value.
Embodiment
The embodiment to the present invention elaborates with reference to embodiments.
The present invention is provided in specific implementation by following examples.
Embodiment 1
The present invention, can also be by following weight meter in specific implementation：4-7 parts of catechu, 5-10 parts of corydalis tuber, charred RADIX ET RHIZOMA RHEI 2-4
4-7 parts of part, 5-10 parts of granatum and baked ginger charcoal are made, and catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, granatum and baked ginger charcoal are mixed, are ground into altogether
The fine powder of 100 mesh sieves is crossed, is sterilized, loading capsule, medicinal powder 0.6g is loaded in every capsule；Or by catechu 4-7g, corydalis tuber 5-
10g, charred RADIX ET RHIZOMA RHEI 2-4g, granatum 5-10g and baked ginger charcoal 4-7g are made, by catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, granatum and baked ginger charcoal
Mixing, was ground into the fine powder of 100 mesh sieves altogether, sterilized, loading capsule, medicinal powder 0.6g is loaded in every capsule.
Embodiment 2
The present invention is in specific implementation, and the Chinese medicine is by following weight meter：5 parts of catechu, 6 parts of corydalis tuber, 3 parts of charred RADIX ET RHIZOMA RHEI,
5 parts of 6 parts of granatum and baked ginger charcoal are made, and catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, granatum and baked ginger charcoal are mixed, 100 mesh were ground into altogether
The fine powder of sieve, sterilization, loading capsule, medicinal powder 0.6g is loaded in every capsule；Or by catechu 5g, corydalis tuber 6g, charred RADIX ET RHIZOMA RHEI 3g,
Granatum 6g, baked ginger charcoal 5g are made, and catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, granatum and baked ginger charcoal are mixed, 100 mesh sieves were ground into altogether
Fine powder, sterilization, loading capsule, medicinal powder 0.6g is loaded in every capsule.
Embodiment 3
The present invention is in specific implementation, and the Chinese medicine can also be by following weight meter：2 parts of catechu, 11 parts of corydalis tuber, charred RADIX ET RHIZOMA RHEI 1
2 parts of part, 11 parts of granatum and baked ginger charcoal are made, and catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, granatum and baked ginger charcoal are mixed, were ground into altogether
The fine powder of 100 mesh sieves, sterilization, loading capsule, medicinal powder 0.6g is loaded in every capsule；Or by catechu 2g, corydalis tuber 11g, big
Yellow charcoal 1g, granatum 11g and baked ginger charcoal 2g are made, and catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, granatum and baked ginger charcoal are mixed, were ground into altogether
The fine powder of 100 mesh sieves, sterilization, loading capsule, medicinal powder 0.6g is loaded in every capsule.
Embodiment 4
The present invention is in specific implementation, and the Chinese medicine also can be by following weight meter：9 parts of catechu, 2 parts of corydalis tuber, charred RADIX ET RHIZOMA RHEI 5
9 parts of part, 2 parts of granatum and baked ginger charcoal are made, and catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, granatum and baked ginger charcoal are mixed, 100 were ground into altogether
The fine powder of mesh sieve, sterilization, loading capsule, medicinal powder 0.6g is loaded in every capsule；Or by catechu 9g, corydalis tuber 2g, charred RADIX ET RHIZOMA RHEI
5g, granatum 2g and baked ginger charcoal 9g are made, and catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, granatum and baked ginger charcoal are mixed, 100 mesh were ground into altogether
The fine powder of sieve, sterilization, loading capsule, medicinal powder 0.6g is loaded in every capsule.
Supported mutually on drug component of the present invention, the effect of leading stagnant, promoting blood circulation and stopping pain, relieving diarrhea with astringents with middle benefit gas can be effective
Extraordinary advantageous effects are achieved for treating diarrhea-type irritability syndrome, and through clinical test, relevant clinical money
Material is as follows：
First, the standard of case is selected
Diarrhea-type irritability syndrome clinical manifestation is to suffer from abdominal pain, abdominal distension, diarrhoea are main shape, typically suffers from diarrhoea daily 3-5 times, greatly
Just in the pasty state or dilute water sample, many band mucus, but without purulence blood, all that there is above-mentioned symptom person, equal alternatively standard of case.
2nd, diagnostic criteria
Using stomachache, abdominal distension, diarrhoea as cardinal symptom, belly has tenderness, typically suffers from diarrhoea daily 3-5 times, stool in the pasty state or
Dilute water sample, many band mucus, but without purulence blood, multiple stool routine and culture are negative, and excrement occult blood test is negative, x-ray barium enema inspection
No positive discovery is looked into, or colon has excitation sign, colon mirror some patientss hyperperistalsis is abnormal without obvious mucous membrane, histology
Check normal, blood, routine urinalysis are normal, erythrocyte sedimentation rate is normal, and the parasite medical history such as no dysentery, blood fluke, therapeutic trial is invalid,
Meet above-mentioned standard person, you can be diagnosed as suffering from diarrhea-type irritability syndrome.
3rd, therapeutic scheme
All that affirmant is taken Chinese medicine of the present invention and treated, 3 times a day, 5 every time, every 0.6g even served 30-40
Its statistics curative effect.
4th, efficacy assessment standard
Cure：Clinical symptom disappearance, stool recovers normal, discontinues medication, more than 1 year without recurrence.
Effectively：Symptom has clear improvement or improved, i.e., stomachache is intended to just, after an action of the bowels alleviate, and diarrhea accompanies mucus conditions and obtained
To improvement, times of defecation is significantly reduced or reduced, and need to continue medication treatment.
It is invalid：Symptom is without any improvement, or even has the trend of exacerbation, need to be treated with other medicines.
5th, statistical procedures
Clinic to 152 patients with diarrhea-type irritability syndrome through pressing above-mentioned therapeutic scheme and efficacy evaluation mark
Standard, is handled, P≤0.05 with SPSSlO.O statistical softwares, and with statistical significance, curative effect statistical result is as follows：
92 people are cured, 60.5% is accounted for, effective 57 people, 37.5%, invalid 3 people accounts for 2%, total effective rate 98%, during medication not
It was found that there is any toxic side effect, show drug safety, curative effect is reliable and stable.
6th, model case
Mucus wind foam sample thing is accompanied in Zhang, man, 36 years old abdominal pain diarrhea stool 3 years, often with feed raw food or greasy food
It is easy to lower-left stomachache occur, pain is then intended to just, just gesture is urgent, alleviates after an action of the bowels.Just it is middle to carry mucus and wind foam shape thing, accidental indigestion secretly
Residue.Once looked into colonoscopy for several times without organic to become, informal dress pill for strengthening spleen and intestines, the medicine such as GUCHANG ZHIXIE WAN, then disease is answered for medication effectively drug withdrawal
As before.Through treatment by Chinese herbs of the present invention 35 days, if all diseases are lost, follow-up 3 years was without recurrence.
7th, conclusion
By it is above-mentioned it is clear that it is of the invention be treat diarrhea-type irritability syndrome active drug, drug safety,
The effect of leading stagnant, promoting blood circulation and stopping pain, relieving diarrhea with astringents with middle benefit gas, effective for treatment diarrhea-type irritability syndrome, curative effect is high, always
Effective percentage up to 98%, is to treat the innovation on diarrhea-type irritability syndrome medicine with very strong clinical value, warp
Ji and social benefit are notable.
Claims (5)
1. a kind of Chinese medicine for treating diarrhea-type irritability syndrome, it is characterised in that by weight meter：1-10 parts of catechu, corydalis tuber
1-12 parts, 0.5-6 parts of charred RADIX ET RHIZOMA RHEI, 1-12 parts of granatum, 1-10 parts of baked ginger charcoal be made, wherein charred RADIX ET RHIZOMA RHEI is by rhubarb tablets rice vinegar
Mix thoroughly, stew to moisten to saturating, put in frying container, heated with slow fire, take out and dry after fried dry, weed out chip；Baked ginger charcoal is to take
Clean sand is put in iron pan, and heating puts into baked ginger when frying to sliding profit, fries to foaming heave with high heat, and appearance takes when being in burnt brown
Go out, weed out sand and ash bits spreading for cooling, catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, granatum and baked ginger charcoal are mixed, 100 mesh were ground into altogether
The fine powder of sieve, sterilization, loading capsule.
2. the Chinese medicine for the treatment of diarrhea-type irritability syndrome according to claim 1, it is characterised in that by following weight meter
's：4-7 parts of 4-7 parts of catechu, 5-10 parts of corydalis tuber, 2-4 parts of charred RADIX ET RHIZOMA RHEI, 5-10 parts of granatum and baked ginger charcoal are made, by catechu, member
Recklessly, charred RADIX ET RHIZOMA RHEI, granatum and the mixing of baked ginger charcoal, were ground into the fine powder of 100 mesh sieves, sterilized altogether, loading capsule, every capsule
Interior loading medicinal powder 0.6g.
3. the Chinese medicine for the treatment of diarrhea-type irritability syndrome according to claim 1, it is characterised in that by following weight meter
's：5 parts of 5 parts of catechu, 6 parts of corydalis tuber, 3 parts of charred RADIX ET RHIZOMA RHEI, 6 parts of granatum and baked ginger charcoal are made, by catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, pomegranate
Skin and the mixing of baked ginger charcoal, were ground into the fine powder of 100 mesh sieves, sterilized altogether, loading capsule, medicinal powder is loaded in every capsule
0.6g。
4. the Chinese medicine for the treatment of diarrhea-type irritability syndrome according to claim 1, it is characterised in that by following weight meter
's：2 parts of 2 parts of catechu, 11 parts of corydalis tuber, 1 part of charred RADIX ET RHIZOMA RHEI, 11 parts of granatum and baked ginger charcoal are made, by catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, stone
Pomegranate skin and the mixing of baked ginger charcoal, were ground into the fine powder of 100 mesh sieves, sterilized altogether, loading capsule, medicinal powder is loaded in every capsule
0.6g。
5. the Chinese medicine for the treatment of diarrhea-type irritability syndrome according to claim 1, it is characterised in that by following weight meter
's：9 parts of 9 parts of catechu, 2 parts of corydalis tuber, 5 parts of charred RADIX ET RHIZOMA RHEI, 2 parts of granatum and baked ginger charcoal are made, by catechu, corydalis tuber, charred RADIX ET RHIZOMA RHEI, pomegranate
Skin and the mixing of baked ginger charcoal, were ground into the fine powder of 100 mesh sieves, sterilized altogether, loading capsule, medicinal powder is loaded in every capsule
0.6g。
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194859A (en) * | 1998-04-03 | 1998-10-07 | 周义坤 | Medicine for treating colitis |
| CN1285213A (en) * | 1999-08-20 | 2001-02-28 | 郑国山 | Chinese patent medicine for treating colitis and preparation process thereof |
| CN102716450A (en) * | 2012-06-18 | 2012-10-10 | 天津开发区经经新优技术产品开发有限公司 | Chinese patent drug and traditional Chinese medicine decoction capable of treating chronic nonspecific colitis effectively |
| CN103520661A (en) * | 2012-07-06 | 2014-01-22 | 王保安 | Traditional Chinese medicinal enteric-coated tablets for treating proctitis, colitis and irritable bowel syndrome, as well as preparation method and application thereof |
-
2014
- 2014-10-14 CN CN201410540501.9A patent/CN104288728B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194859A (en) * | 1998-04-03 | 1998-10-07 | 周义坤 | Medicine for treating colitis |
| CN1285213A (en) * | 1999-08-20 | 2001-02-28 | 郑国山 | Chinese patent medicine for treating colitis and preparation process thereof |
| CN102716450A (en) * | 2012-06-18 | 2012-10-10 | 天津开发区经经新优技术产品开发有限公司 | Chinese patent drug and traditional Chinese medicine decoction capable of treating chronic nonspecific colitis effectively |
| CN103520661A (en) * | 2012-07-06 | 2014-01-22 | 王保安 | Traditional Chinese medicinal enteric-coated tablets for treating proctitis, colitis and irritable bowel syndrome, as well as preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| "20年来中医药治疗肠易激综合征回顾分析";张正利等;《中医杂志》;20010630;第42卷(第6期);373-375 * |
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