CN1042839A - The apparatus for supplying electric energy to biological tissue of simulated physiological healing process - Google Patents
The apparatus for supplying electric energy to biological tissue of simulated physiological healing process Download PDFInfo
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- CN1042839A CN1042839A CN 88108197 CN88108197A CN1042839A CN 1042839 A CN1042839 A CN 1042839A CN 88108197 CN88108197 CN 88108197 CN 88108197 A CN88108197 A CN 88108197A CN 1042839 A CN1042839 A CN 1042839A
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Abstract
The present invention relates to a kind of equipment to biological tissue's power supply, the purpose of power supply is in order to help to support various physiological process, the different phase that comprises healing, growth and the variation of some pathological states equally also is in order to influence for example vigor situation of tumor tissues.This equipment mainly comprises at least two electrodes that connect direct voltage source, and this voltage source then is arranged to supply with electric current by this two electrode and is flow through described biological tissue.In order to simulate the physiology therapeutic process, voltage source provides its amplitude electric current of alternation in time, and the absolute value of the extreme value of each amplitude is less than the absolute value of previous amplitude extreme value and then.At last, make the alternation of electric current repeat to take place for several times.
Description
The present invention relates to a kind of equipment to biological tissue's supply of electrical energy, the purpose of power supply is in order to help to support various physiological process, the variant stage that comprises healing, growth and the variation of some pathological states, for example hydrops or the like in the decay of blood flow, chronic pain, the tissue equally also is in order to influence for example vigor situation of tumor tissues.This equipment mainly comprises at least two electrodes that connect direct voltage source, one of them electrode will be placed in the biological tissue that its physiology or pathology-physiology circulation remains to help to support or in the biological tissue, another electrode then will be placed on such one and be separated by on the position of a segment distance with this biological tissue, make to form the galvanic circle between this two electrode that this voltage source then is arranged to supply with electric current by described biological tissue by this two electrode.
Just knowing in the art in the past, can by in tissue part to be treated or the electrode media of outer different designs power to biological tissue.Under the situation of the prior art, electrode system is connected on the specially designed current emission device.This current emission device especially destroys tumor tissues from that a kind of being described to that Swedish patent 7812092-0 knows with it.
Also can make tissue coagulation with the high-power input of high frequency by radiation with the galvanothermotherapy instrument.
Known method also has so-called applying at the electrode two ends of being inserted to stimulate catagmatic method, and in the outside method that applies constant or alternating electromagnetic field from the Helmholtz loop of fracture.As far as we know, these methods of prior art are not based on the physiological requirement that is organized in that will treat, and these require many critical aspect, have no talent so far and know.
Main purpose of the present invention is to propose a kind of equipment, can make the emission of electric current adapt to the situation of change that is organized in physiology and the pathological reaction with this equipment, thereby reach good curative effect.
With the achieve the above object equipment of usefulness of the described confession of introducing of mode is design like this, for simulated physiological healing process, above-mentioned voltage source provides the amplitude electric current of alternation in time, the absolute value of the extreme value of each amplitude of this electric current is less than the absolute value of the extreme value of the amplitude of back to back last time, and impels the alternation process of above-mentioned electric current to repeat repeatedly.
From the following character that can be more readily understood the present invention and each side thereof to the cutline and the relevant argumentation of accompanying drawing.
In the accompanying drawing:
Fig. 1 is for illustrating the block diagram in the appropriate voltage source of selecting for use;
Fig. 2 is the curve chart of voltage as the function of time.
Referring to accompanying drawing.Different with existing therapeutic equipment, embodiments of the invention are needed according to different pathological status to be basic to supply of electric power different support or change requirement.These requirements (must plan in advance before carrying out the difference treatment) just can be applicable among the present invention at that time, in one embodiment, it can be become certain procedure by different function weavings.By using these functions to have broad programming possible range, just can apply the present invention to several different states, for example fracture or the treatment of the healing of wound, rheumatic arthritis, glaucoma, tumor tissues etc.
Based on the inventor for many years practical experience and to the treatment of cancer patient, here the healing that the present invention analyses with bone is as an example that helps the supporting tissue healing, and the healing of this fracture fundamentally it seems be all the time according to the present invention based on cardinal principle carry out.
According to this cardinal principle, in each fracture or other tissue injury, can produce degenerating naturally of tissue, the natural degeneration of this tissue can cause the activation polarization effect with respect to unmarred tissue around it of the tissue of damaged.This polarization is electropositive when beginning, and its size is at the order of magnitude of hundreds of millivolt, and this polarization formative tissue material electricity causes the electric power in the transmission system.In the example of in teat glass, in animal and patient body, testing that is about to introduce in detail below the inventor is applied to this cardinal principle recently.
This cardinal principle comprises not known facts before some, a kind of new function of blood vessel for example, and promptly the resistivity of blood vessel wall is than conducting medium (being blood plasma) height.Blood vessel has the electrical transmission ability by the blood capillary intermediate, under the effect in the synergetic electronic field of force, the blood capillary local contraction.Therefore ion is transmitted in the ion channel that forms by the endotheliocyte of blood capillary and seepage aperture therebetween by locking, has so just got rid of the influence of the permeable pressure head on seepage pressure reduction and the blood capillary and the effect of gravity.On the other hand, synergetic electric field degree of passing can by globular preteins with at first in inner mitochondria film, showed by Bi Demixieer (Peter Mitchell) and can show that at this mode that is present in the endothelial cell membrane brings out electronics and traverse endothelial cell migration.So when electron transfer, just produced the biological phenomena that is equivalent to the electrode reaction aspect the electrophoresis.Therefore, the electric power that is produced in damage location can be ordered about ion and flowed in a blood vessel and a matter conductive tissue liquid.This is the ultimate principle of the caused transmission course of material of damage location in agglutination.
This transmission system is in electropositive at the tissue injury position makes anion accumulate during the stage, cation is repelled.In the latter half, damage location becomes becomes elecrtonegativity with respect to its peripheral part, this be identified and the specific current transmission system of planning in, the counter-rotating of current delivery process, so cation is accumulated, anion is damaged the position to be repelled.This circulation is characterised in that, with near surrounding tissue a potential difference that can decay according to the fluctuation that is used by the present invention is arranged.In order to heal, each tissue injury's part had both needed anion also to need cation, but these ions must be used by the order of determining.The total electricity of transmitting is a key.This can calculate on the basis of determining tissue injury's size.Experiment confirm the gross energy that discharges at damage location with for healing damages can provide between energy-current delivery amount direct relation is arranged.In brief, in normal agglutination, damage location itself can provide healing damaged portion energy needed.
If tissue injury is electropositive fully, then cumulative therein have only anion, and cation can be repelled there simultaneously.Spontaneous reason had both needed anion also to need cation in the agglutination.Showed already in zoopery that the current potential of damage location is slowly fluctuation in time.Therefore concerning certain given damage location, ionic transmission course must be subjected to the influence of surrounding tissue electric conductivity especially.Under the good situation of conduction, certain given electric power can be not only in the electropositive stage of damage location but also in its elecrtonegativity stage is between short-term, transmit the ion of capacity, damage location promptly heals rapidly.Under the bad situation of conduction, these transmission courses just need the long time, may also need an adjustable current source to help support it.We studied the practical wave pattern of the union of fracture of aggressivity fracture by experiment, and this figure has been listed polarity, voltage and the electromotive force of giving when transmitting during the needed healing time of damage location of sizing a certain respectively.
The definite of damage location size can adopt noninvasive method before the treatment, for example X ray, electronic computer X-ray topography and magnetic resonance etc.Because the decay of little damage discharges the energy that the change in voltage that is equivalent to macrolesion can be provided, therefore cure the damage ion transfer amount in each required stage by means of definite might the calculating of damage location size.This can be by calculating and mix electric current that the present invention will provide to the integration of time, maybe ought have the level of enough ion transfer to realize by detecting actual current path of the present invention and making voltage be elevated to suitable stage during making at the fixed time.
Above-mentioned disclosure has been arranged as a setting, the present invention enjoys following performance.Adopt preferably rechargeable but when using can with the isolating battery of charge power supply, regulating voltage and electromotive force can utilize the electropositive of damage location and elecrtonegativity stage with ion drive to expel fracture portions.In one embodiment, might apply gratifying positive voltage so that accumulate the anion of capacity at the time durations that adapts to.When accumulating the current value of required usefulness near the anion that calculates, after determining the size of damage location in advance, the level that electric current is through-flow was time of 0.1 to 10 day, preferably about a week, level off to null value, begin the desired elecrtonegativity stage that has after this, so that make current reversal or alternation.In this way, in the corresponding way the integration of flowing time is programmed on the occasion of.After this, voltage pulsation, the voltage that is changing all decay, occur until fracture portions till the stability of clinical property, in other words, till damaged portion is fully recovered basically.
The suitable enforcement of choosing an as an example voltage source of the present invention is shown in the block diagram of Fig. 1.This direct voltage source preferably includes the accumulator or the battery (not being shown specifically among the figure) of available alternating current power supply charging.The mode that this charging back breaks away from alternating current power supply is recommendable, because can avoid interference, transient voltage etc. from alternating current power supply to influence the risk of direct voltage source like this.
Direct voltage source comprises a clock 1 of suitably being controlled by crystal 2, and this clock is established for the control therapeutic process.On the measured display that is presented at suitable type in real time 3 of clock 1.Clock 1 is by being connected on an intermediary for example relay (not being shown specifically among the figure), two switch reed 4 and 5 work that act on the current feedback circuit 6, be connected to the electric current that patient's contact 7 and 8 on one's body sends to increase or to reduce from two, this electric current then is supplied to its physiology and circulates in the biological tissue that remains to help to support by implant electrode (not shown) in the tissue part to be treated with the surgery art.
As supplemental facilities or substitute by crystal-controlled clock 1, certainly but setting up procedure control appliance (not shown) is for the usefulness of programming, just can make by means of this equipment in the empirical data, ultimate value etc. of previous acquisition and the therapeutic process the numerical value finding or detect by rights to the initial value generation effect of the interval of relevant electric current that current feedback circuit 6 produced, voltage, electric current, change degree etc.This is meant that especially those can more promptly detect the result of agglutination, thereby accurately determines when introduce the situation in the next stage of healing process by changing electric current substantially.
Direct voltage source comprises that also one is used for continuous or instantaneous reading by switching device 10 and searches from current feedback circuit 6, and is presented at the virtual voltage on the display 3 and the instrument of electric current.Charging instrument 11 continues to be connected on the current feedback circuit 6, and its value is also shown on the display 3.In this case, charging instrument 11 is absolutely necessary, because as mentioned above, the charge volume that supply with the tissue of damaged is directly relevant with the size of damage itself.Availablely after enough charging current amounts are added to therapentic part manually delivery is reduced to zero.On the other hand,, then charge volume of being programmed and the charge volume that is added to contact 7 and 8 can be compared, when these values equate, then electric current be reduced to zero if adopt programming device, and/or from current feedback circuit 6 automatic alternation power supplies.
It should be understood that in addition, as a supplement or another selection scheme, beginning before the current feedback circuit power supply, can utilize electrode in the implant biological tissue detecting the sense of current of physiological healing process, and the sense of current and this sense of current that current feedback circuit 6 is sent are adapting.
But usually only is beginning corresponding to the normal healing process, uses the electric current begin treatment that sends from the defect table tissue at the very start.
By the increase and the minimizing of the electric current that sent via the current feedback circuit 6 of relay control by clock 1, can make the electric current mode of controlling by time variable increase step by step and reduce respectively, but but certain also suitable method of mat electric current is increased continuously and reduces.
Fig. 2 illustration be added to contact 7 and 8 two ends voltage curve by current feedback circuit 6 as the function of time because (under the quite constant situation of the resistivity of biological tissue) changes compared with corresponding electric current basically, voltage ratio is easy to control.Here the time axis T among the figure comprises the time in about 3～4 week, and from curve obviously as can be seen, is subjected to damping and progressively trends towards zero at this this curve of interval end.Initial current is added to first maximum needs several seconds, the longlyest need a few minutes, on the other hand, progressively or continuously carry out by this maximum to zero variation, last 0.1 to 2 day, reach most 7～10 days, electric current continues to change to minus maximum then, returns zero, required period of this section is with above-mentioned substantially the same, promptly (when curtage is generally, but not necessarily non-be like this, in the time of zero) two each other continuously the distance between the point of alternations be about 7 days.Therefore the speed of its alternation of electric current that adds to electrode contact 7 and 8 is very slow.After the sense of current alternation 3～4 times, cure basically, but a condition is arranged, promptly be added to big or small corresponding that structural total electric weight basically should be with wound.
The present invention should not be construed as the restriction that is subjected to the content shown in above-mentioned and the accompanying drawing, it is contemplated that multiple variants and modifications under the prerequisite of spirit that does not break away from this description appended claims and scope.
Claims (8)
1, a kind of equipment to biological tissue's supply of electrical energy, the purpose of power supply is in order to help to support various physiological process, comprise the healing of some pathological states, the different phase of growth and variation, the for example decay of blood flow, chronic pain, hydrops etc. in the tissue, equally also be in order to influence for example vigor situation of tumor tissues, this equipment mainly comprises at least two electrodes that connect direct voltage source, one of them electrode will be placed on its physiology or pathology-physiology circulation to be needed in the biological tissue of in addition collaboration or in the biological tissue, another electrode then is configured in such position with this biological tissue segment distance of being separated by, make and between this two electrode, form the galvanic circle, this voltage source then is configured to supply with electric current by this biological tissue by this two electrode, this equipment is characterised in that, for simulated physiological healing process, described voltage source system designs to such an extent that can provide its amplitude in time and the electric current of alternation; The extreme value of each amplitude on absolute value less than the absolute value of the extreme value of the amplitude of back to back last time; And the alternation process of described electric current is repeated repeatedly.
2, equipment as claimed in claim 1 is characterized in that, makes the interval of alternation between 0.1 and 10 day of the electric current that produces because of voltage source, preferably takes place within about 7 days.
As the described equipment of above arbitrary claim, it is characterized in that 3, the electric current that this equipment is arranged to be presented by described two electrodes by voltage source is added up in time; This total cumulative amount is selected according to the volume size of the tissue of wanting to be helped to support in advance; In a single day and when reaching described cumulative amount, operate electric current is disconnected from voltage source automatically.
4, as the described equipment of above arbitrary claim, it comprises a device of using in order to the analog result that detects the physiological healing process produced, this equipment is characterised in that, described voltage source is to design to such an extent that make its control that is subjected to the detected result of said apparatus, changes each corresponding time point of electric current alternation.
5, as the described equipment of above arbitrary claim, it is characterized in that, described alternation system from the electric current of voltage source is provided with to such an extent that make it rise to the extreme value of amplitude at leisure, continuously or step by step from null amplitude, so that drop to null value in after this during a couple of days, and alternation is to minus amplitude extreme value again, and the absolute value of this minus amplitude extreme value is less than the extreme value of back to back previous amplitude; And should value from described minus amplitude extreme value, during a couple of days, rise to zero once more, alternation to a new true amplitude extreme value then, but the absolute value of this new true amplitude extreme value is less than the absolute value of back to back previous minus amplitude extreme value; And voltage source repeats above-mentioned alternation circulation, till the result who expects up to reaching.
6, as the described equipment of above arbitrary claim, having one is used for the previous experience data, handles the programmer that the detected value etc. of electric current is programmed, described equipment is characterised in that described voltage source is to be configured to make it to be controlled by described programmer.
As the described equipment of above arbitrary claim, it is characterized in that 7, described voltage source is configured to make it at first to produce with the electric current of a direction from an electrode stream to another electrode.
As the described equipment of above arbitrary claim, it is characterized in that 8, described voltage source system is configured at first to produce one with the sense of current same phase of physiological healing process or make its synchronous electric current.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88108197 CN1042839A (en) | 1988-11-26 | 1988-11-26 | The apparatus for supplying electric energy to biological tissue of simulated physiological healing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88108197 CN1042839A (en) | 1988-11-26 | 1988-11-26 | The apparatus for supplying electric energy to biological tissue of simulated physiological healing process |
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| Publication Number | Publication Date |
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| CN1042839A true CN1042839A (en) | 1990-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 88108197 Pending CN1042839A (en) | 1988-11-26 | 1988-11-26 | The apparatus for supplying electric energy to biological tissue of simulated physiological healing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247651A (en) * | 2003-09-30 | 2011-11-23 | 突触微电流有限公司 | Dressing having electrodes and conductive gel for electrical treatment of damaged tissue |
| WO2021004537A1 (en) * | 2019-07-10 | 2021-01-14 | 上海必修福企业管理有限公司 | Electric field generation device and use thereof, and disease effusion discharging method using same |
-
1988
- 1988-11-26 CN CN 88108197 patent/CN1042839A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247651A (en) * | 2003-09-30 | 2011-11-23 | 突触微电流有限公司 | Dressing having electrodes and conductive gel for electrical treatment of damaged tissue |
| CN102247651B (en) * | 2003-09-30 | 2015-11-25 | 突触微电流有限公司 | A kind of binder for the treatment of cell tissue |
| WO2021004537A1 (en) * | 2019-07-10 | 2021-01-14 | 上海必修福企业管理有限公司 | Electric field generation device and use thereof, and disease effusion discharging method using same |
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