CN104275329A - Ultrasonic cleaning device provided with chromatographic column or guard column - Google Patents
Ultrasonic cleaning device provided with chromatographic column or guard column Download PDFInfo
- Publication number
- CN104275329A CN104275329A CN201410573764.XA CN201410573764A CN104275329A CN 104275329 A CN104275329 A CN 104275329A CN 201410573764 A CN201410573764 A CN 201410573764A CN 104275329 A CN104275329 A CN 104275329A
- Authority
- CN
- China
- Prior art keywords
- chromatographic column
- column
- sleeve pipe
- amplitude transformer
- sleeve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
- B08B3/12—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration by sonic or ultrasonic vibrations
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/0804—Cleaning containers having tubular shape, e.g. casks, barrels, drums
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B2209/00—Details of machines or methods for cleaning hollow articles
- B08B2209/08—Details of machines or methods for cleaning containers, e.g. tanks
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention belongs to the field of a liquid chromatography analytical instrument, and particularly relates to an ultrasonic cleaning device provided with a chromatographic column or a guard column. The device comprises an energy supply device (1), a cooling device (4), a sleeve (5) provided with a lower end liquid flow channel tube (8) at the bottom, and a sleeve cover (7) provided with an upper end liquid flow channel tube (9) on the top, wherein the lower end of the energy supply device (1) is provided with an ultrasonic transducer (2), an energy accumulator (3) is arranged at the upper end of the energy supply device (1), and the energy accumulator (3) is closed up towards the longitudinal center line from bottom to top; the top of the energy accumulator (3) is fixedly connected with the sleeve (5); the sleeve (5) is internally provided with a cavity; the size of the cavity is matched with that of the chromatographic column or the guard column; the sleeve cover (7) is connected with the sleeve (5) in a sealing way; the cooling device (4) is arranged on the outer wall of the energy accumulator (3). The device is used for cleaning by the cleaning liquid flowing through the chromatographic column, does not need to be disassembled and cleaned, and is convenient to use; the chromatographic column is prevented from being blocked.
Description
Technical field
The invention belongs to chromatographic analyzer of liquid phase device field, be specifically related to a kind of chromatographic column or guard column ultrasonic cleaning equipment.
Background technology
Chromatographic column is core component in liquid-phase chromatographic analysis, and there are permeability sieve plate and filler in chromatographic column inside, and guard column is usually short than chromatographic column, and also there are permeability sieve plate and filler in inside, uses before being added in chromatographic column as field-replaceable unit.
During liquid chromatogram work, mobile phase and sample, by chromatographic column, therefore easily block chromatographic column sieve plate and filler with the insoluble substance of mobile phase in sample, cause pressure to raise, and seriously make to cause instrument to work or chromatographic column damage.After chromatographic column or pre-column block, chromatographic column connector will be taken apart by existing cleaning method usually, sieve plate or the taking-up of other parts is placed in ultrasonic cleaner and cleans; The program of dismounting chromatographic column is consuming time, and there is the risk making chromatographic column inner stuffing connection loosing, chromatographic column may be caused time serious not use, in ultrasonic cleaner, power density is less in addition, therefore the scavenging period needed is long, also have this cleaning way to disassemble chromatographic column, the on-line cleaning under chromatographic column duty can not be realized.
Summary of the invention
For the deficiencies in the prior art; the present invention aims to provide a kind of chromatographic column ultrasonic cleaning equipment; the chromatographic column of this cleaning device or guard column can closely and sleeve surface fit; the liquid flow through or reside in chromatographic column/guard column is as cleaning fluid; ultrasonic wave is made to form cavitation, acceleration effect and direct flow effect in a liquid; thus make that the crud layer of sieve plate in chromatographic column, filler and inner surface is disperseed, emulsification, stripping, reach cleaning object.
For achieving the above object, technical scheme of the present invention is:
A kind of chromatographic column or guard column ultrasonic cleaning equipment, comprise power supply device, also comprise heat abstractor, casing cover that sleeve pipe that bottom is provided with lower end liquid flow path pipe and top are provided with upper end liquid flow path pipe; The lower end of described power supply device is ultrasonic transducer, and the upper end of power supply device is amplitude transformer, and amplitude transformer draws in longitudinal centre line from the bottom to top; Described amplitude transformer top is fixedly connected with sleeve pipe; Have cavity in described sleeve pipe, the size of the size of this cavity and chromatographic column or guard column matches; Described casing cover is connected with bobbin seal; Described heat abstractor is arranged on the outer wall of amplitude transformer.
Preferred described amplitude transformer top is fixedly connected with sleeve bottom, or amplitude transformer top is fixedly connected with sleeve side walls.
Described being fixedly connected with preferably is welded or is threaded.
Described heat abstractor is preferably below sidewall and is provided with radiator liquid flow channel tube a, is provided with radiator liquid flow channel tube b above sidewall.
Chromatographic column or guard column are placed in the cavity of sleeve pipe, and fit with sleeve pipe.
The present invention will be further explained below:
The course of work is explained: sleeve pipe is closely coupled on amplitude transformer by modes such as welding, be threaded, or sleeve pipe and amplitude transformer also can integrated machine-shapings, and chromatographic column is placed in sleeve pipe, is compressed by casing cover, can fit with the tight of amplitude transformer, casing cover is connected with bobbin seal; Chromatographic column lower end is closely attached to amplitude transformer surface; Liquid flows into from casing cover or bottom conduit, flows out, make to be full of liquid in chromatographic column/guard column from other end; After chromatographic column exists liquid, start power supply, ultrasonic transducer produces mechanical energy, and is delivered in the liquid in chromatographic column by amplitude transformer, by the cavitation of liquid, acceleration effect and direct flow action effect cleaning chromatographic column.
Energy accumulating to top, is strengthened ultrasonic power density by amplitude transformer.
The heat energy of generation is taken away by heat abstractor, avoids system overheat.
The pipeline at sleeve pipe two is connected in liquid chromatograph, can function of on-line cleaning be realized.
Amplitude transformer surface should be close in chromatographic column lower end, and the mechanical energy that ultrasonic wave is produced is directly delivered in the liquid in chromatographic column, improves ultrasonic efficiency.
Sleeve pipe is connected with amplitude transformer top, can be upright, tilt, horizontal direction.
Compared with prior art, advantage of the present invention is:
1, chromatographic column ultrasonic cleaning equipment of the present invention; the chromatographic column of this cleaning device or guard column can closely and sleeve surface fit; the liquid flow through or reside in chromatographic column/guard column is as cleaning fluid; ultrasonic wave is made to form cavitation, acceleration effect and direct flow effect in a liquid; thus make that the crud layer of sieve plate in chromatographic column, filler and inner surface is disperseed, emulsification, stripping, reach cleaning object.
2, due to amplitude transformer effect, make larger ultrasonic energy concentrate on the cleaning position of chromatographic column, obtain larger power density, strengthen cleaning performance.
3, do not need in use procedure to disassemble chromatographic column, easy to operate.Can also clean in real time by during chromatographic column at liquid chromatogram mobile phase, realize the object of on-line cleaning, extend chromatographic column service life.
Accompanying drawing explanation
Fig. 1 is the decomposition texture schematic diagram of a kind of chromatographic column ultrasonic cleaning equipment embodiment of the present invention:
Fig. 2 is the decomposition texture schematic diagram of the another kind of embodiment of a kind of chromatographic column ultrasonic cleaning equipment of the present invention:
Wherein, 1 is power supply device, and 2 is ultrasonic transducers, and 3 is amplitude transformers; 4 is heat abstractors, and 5 is sleeve pipes, and 6 is chromatographic column or guard column, and 7 is casing covers; 8 is lower end liquid flow path pipes, and 9 is upper end liquid flow path pipes, and 10 is radiator liquid flow channel tube a, and 11 is radiator liquid flow channel tube b.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is described further.
embodiment 1:
As shown in Figure 1, a kind of chromatographic column ultrasonic cleaning equipment, comprises power supply device 1, also comprises heat abstractor 4, casing cover 7 that sleeve pipe 5 that bottom is provided with lower end liquid flow path pipe 8 and top are provided with upper end liquid flow path pipe 9; The lower end of described power supply device 1 is ultrasonic transducer 2, and the upper end of power supply device 1 is amplitude transformer 3, and amplitude transformer 3 draws in longitudinal centre line from the bottom to top; Amplitude transformer 3 top is fixedly connected with bottom sleeve pipe 5; Tool cavity in sleeve pipe 5, the size of the size of this cavity and chromatographic column or guard column matches; Casing cover 7 and sleeve pipe 5 are tightly connected; Described heat abstractor 4 is arranged on the outer wall of amplitude transformer 3.Chromatographic column or guard column are placed in the cavity of sleeve pipe, and fit tightly with sleeve pipe.
Describedly be fixedly connected as welding.Be provided with radiator liquid flow channel tube a10 below the sidewall of described heat abstractor 4, above sidewall, be provided with radiator liquid flow channel tube b11.
Chromatographic column 6 is placed in sleeve pipe 5, when after Sealed casing pipe lid 7, chromatographic column lower end is closely attached to amplitude transformer surface, after there is liquid in chromatographic column, start power supply, ultrasonic transducer 2 produces mechanical energy, and is delivered in the liquid in chromatographic column by amplitude transformer 3, makes the cavitation of liquid, acceleration effect and direct flow effect clean chromatographic column by ultrasonic wave.
embodiment 2:
As shown in Figure 2, other annexation is with embodiment 1, and just amplitude transformer 3 top is fixedly connected with (horizontal positioned) with sleeve pipe 5 sidewall; Chromatographic column 6 is placed in sleeve pipe 5, and fits with sleeve pipe 5.
Claims (5)
1. a chromatographic column or guard column ultrasonic cleaning equipment, comprise power supply device (1), it is characterized in that, also comprise heat abstractor (4), casing cover (7) that sleeve pipe (5) that bottom is provided with lower end liquid flow path pipe (8) and top are provided with upper end liquid flow path pipe (9); The lower end of described power supply device (1) is ultrasonic transducer (2), and the upper end of power supply device (1) is amplitude transformer (3), and amplitude transformer (3) draws in longitudinal centre line from the bottom to top; Described amplitude transformer (3) top is fixedly connected with sleeve pipe (5); Described sleeve pipe has cavity in (5), and the size of the size of this cavity and chromatographic column or guard column matches; Described casing cover (7) and sleeve pipe (5) are tightly connected; Described heat abstractor (4) is arranged on the outer wall of amplitude transformer (3).
2. chromatographic column or guard column ultrasonic cleaning equipment according to claim 1, is characterized in that, described amplitude transformer (3) top is fixedly connected with sleeve pipe (5) bottom, or amplitude transformer (3) top is fixedly connected with sleeve pipe (5) sidewall.
3. chromatographic column or guard column ultrasonic cleaning equipment according to claim 1 or 2, is characterized in that, described in be fixedly connected as welding or be threaded.
4. chromatographic column or guard column ultrasonic cleaning equipment according to claim 1 or 2, is characterized in that, is provided with radiator liquid flow channel tube a(10 below the sidewall of described heat abstractor (4)), be provided with radiator liquid flow channel tube b(11 above sidewall).
5. chromatographic column or guard column ultrasonic cleaning equipment according to claim 1 or 2, is characterized in that, chromatographic column or guard column (6) are placed in the cavity of sleeve pipe (5), and fit with sleeve pipe (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410573764.XA CN104275329B (en) | 2014-10-24 | 2014-10-24 | A kind of chromatographic column or guard column ultrasonic cleaning equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410573764.XA CN104275329B (en) | 2014-10-24 | 2014-10-24 | A kind of chromatographic column or guard column ultrasonic cleaning equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104275329A true CN104275329A (en) | 2015-01-14 |
| CN104275329B CN104275329B (en) | 2016-01-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410573764.XA Active CN104275329B (en) | 2014-10-24 | 2014-10-24 | A kind of chromatographic column or guard column ultrasonic cleaning equipment |
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| CN (1) | CN104275329B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1613273A (en) * | 2002-09-23 | 2005-05-04 | 顶峰集团有限公司 | Sleeved ultrasonic transducer |
| CN101142619A (en) * | 2005-02-15 | 2008-03-12 | 迪特尔·韦伯 | Rod-shaped ultrasonic resonator for producing ultrasound in liquids |
| JP2011152376A (en) * | 2010-01-25 | 2011-08-11 | Takayuki Adachi | Combination washing method of rice bran soybean brewing extracting component-based washing liquid diluted with energy charging water and high-frequency vibration washing machine |
| CN203635562U (en) * | 2013-10-25 | 2014-06-11 | 江苏鑫润环保科技有限公司 | Improved washing connector for gas chromatography |
| CN204074619U (en) * | 2014-10-24 | 2015-01-07 | 王峰 | A kind of chromatographic column or guard column ultrasonic cleaning equipment |
-
2014
- 2014-10-24 CN CN201410573764.XA patent/CN104275329B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1613273A (en) * | 2002-09-23 | 2005-05-04 | 顶峰集团有限公司 | Sleeved ultrasonic transducer |
| CN101142619A (en) * | 2005-02-15 | 2008-03-12 | 迪特尔·韦伯 | Rod-shaped ultrasonic resonator for producing ultrasound in liquids |
| JP2011152376A (en) * | 2010-01-25 | 2011-08-11 | Takayuki Adachi | Combination washing method of rice bran soybean brewing extracting component-based washing liquid diluted with energy charging water and high-frequency vibration washing machine |
| CN203635562U (en) * | 2013-10-25 | 2014-06-11 | 江苏鑫润环保科技有限公司 | Improved washing connector for gas chromatography |
| CN204074619U (en) * | 2014-10-24 | 2015-01-07 | 王峰 | A kind of chromatographic column or guard column ultrasonic cleaning equipment |
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| Publication number | Publication date |
|---|---|
| CN104275329B (en) | 2016-01-06 |
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Effective date of registration: 20230331 Address after: 410000 139 people's Middle Road, Furong district, Changsha, Hunan Patentee after: THE SECOND XIANGYA HOSPITAL OF CENTRAL SOUTH University Address before: 410011 No. 139 Renmin Middle Road, Hunan, Changsha Patentee before: Wang Feng Patentee before: THE SECOND XIANGYA HOSPITAL OF CENTRAL SOUTH University |