CN104264372B - Method for preparing PNIPAAm (poly(N-isopropylacrylamide)) and EC (ethyecellulose) blended nano-fiber membrane by electrostatic spinning - Google Patents
Method for preparing PNIPAAm (poly(N-isopropylacrylamide)) and EC (ethyecellulose) blended nano-fiber membrane by electrostatic spinning Download PDFInfo
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- CN104264372B CN104264372B CN201410397888.7A CN201410397888A CN104264372B CN 104264372 B CN104264372 B CN 104264372B CN 201410397888 A CN201410397888 A CN 201410397888A CN 104264372 B CN104264372 B CN 104264372B
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- isopropylacrylamide
- ethyl cellulose
- pnipaam
- electrostatic spinning
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Abstract
The invention relates to a method for preparing an PNIPAAm (poly(N-isopropylacrylamide)) and EC (ethyecellulose) blended nano-fiber membrane by electrostatic spinning. The method includes: dissolving PNIPAAm and EC mixture in absolute ethyl alcohol to obtain electrostatic spinning solution, and performing electrostatic spinning to obtain the PNIPAAm and EC blended nano-fiber membrane. The weight ratio of the PNIPAAm to the EC is (1:1)-(1:4). The method is simple to operate, economical and environment-friendly and has promising application prospect; according to the method, the nano-fiber membrane is prepared just by performing electrostatic spinning on the PNIPAAm and EC mixed solution and can be used as a potential slow release material for pharmaceuticals.
Description
Technical field
The invention belongs to the preparation field of nano fibrous membrane, particularly to a kind of electro-spinning for poly- n- isopropyl acrylamide
The method of amine and ethyl cellulose mixing nano fibrous membrane.
Background technology
Have in functional high molecule material all, polymer pnipaam is current using a class temperature widely
Degree sensitive material, because pnipaam has unsurpassed performance in terms of water solublity and biocompatibility, therefore in industry, agriculture
Industry and medical domain have application widely, have both contained hydrophobic isopropyl group and containing hydrophilic amide groups in its molecule
Group, wherein, amide group can produce strong hydrogen bond action with water.It is less than critical compatible temperature (about 32 DEG C) in temperature,
Amide group in pnipaam can form intermolecular hydrogen bonding, thus improve the compatibility with water, such polymer segment with water
Extend in water, whole macromolecule shows hydrophilicity.When the temperature increases (generally more than 32 DEG C), pnipaam is mutual with aqueous phase
The hydrogen bond of effect can there occurs change, and especially amide and the hydrogen bond of water is destroyed, the solvation of macromole carbochain hydrophobic part
Layer is also destroyed therewith, and the isopropyl of pnipaam macromole exposes outside, forms hydrophobic layer, extrudes original moisture, and high
Molecule segment is reunited each other together.The temperature sensitive performance of pnipaam is thus shown by the change of hydrogen bond.
Electrostatic spinning be polymer solution or melt in the presence of high-pressure electrostatic, taylor can be formed at spinning nozzle
Cone, when electric field intensity reaches a marginal value, electric field force just can overcome the surface tension of liquid, forms one at spinning nozzle
Powered injection stream.In course of injection, the surface area due to injection stream rapidly increases, and solvent volatilizees, fiber solidifying and unordered shape
It is arranged on collection device thus obtaining the nanofiber of our needs.The fibre diameter of electrospinning preparation can be received tens of
Rice is between hundreds of nanometers.Up to the present it has been reported that there being about 100 kinds of polymer to utilize electrostatic spinning technique to prepare excess of export
Thin nanofiber.Electrostatic spinning be obtained nanofiber due to having extraordinary biocompatibility and structural compatibility,
It is widely applied at aspects such as tissue engineering bracket, repair in trauma, drug release controls.
Content of the invention
The technical problem to be solved is to provide a kind of electro-spinning for poly- n- N-isopropylacrylamide and ethyl
The method of cellulose mixing nano fibrous membrane, this inventive method is simple and direct, efficient, novel and easy to operate, has good answering
Use prospect.
A kind of electro-spinning of the present invention is for poly- n- N-isopropylacrylamide and ethyl cellulose mixing nano fibrous membrane
Method, comprising:
The mixture of pnipaam and ec is dissolved, is obtained electrostatic spinning liquid, carry out electrostatic spinning, obtain final product
The mixing nano fibrous membrane of pnipaam/ec；Wherein, poly- n- N-isopropylacrylamide and the mass ratio of ethyl cellulose are 1: 1-
4.
The described poly- n- N-isopropylacrylamide and the solvent of ethyl cellulose mixture of dissolving is dehydrated alcohol.
Described pnipaam is 25% grams per milliliter with the concentration of ec mixed solution.
The mass ratio of described pnipaam and ec is 1: 2,1: 3 or 1: 4.
Described electrostatic spinning process parameter is: voltage 12-13 kilovolt, accepts apart from 130-150 millimeter, syringe propulsion speed
Degree: 0.4-0.5 ml/hour.
The mixing nano fibrous membrane of described preparation is 10*10cm.
Beneficial effect
(1) preparation method of the present invention is simple to operate and economic and environment-friendly, has broad application prospects；
(2) present invention is exactly to prepare nano fibrous membrane to pnipaam with ec mixed solution Electrospun, can be used as a kind of latent
Thermosensitive Material Used for Controlled Releasing of Medicine.
Brief description
Fig. 1 is the scanning of embodiment 1 (pnipaam and ec nanometer composite fibre film (pnipaam and ec mass ratio are 1: 2))
Electromicroscopic photograph；
Fig. 2 is the scanning of embodiment 2 (pnipaam and ec nanometer composite fibre film (pnipaam and ec mass ratio are 1: 3))
Electromicroscopic photograph；
Fig. 3 is the infrared of embodiment 3 (pnipaam and ec nanometer composite fibre film (pnipaam and ec mass ratio are 1: 4))
Spectrogram.
Specific embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention
Rather than restriction the scope of the present invention.In addition, it is to be understood that after having read the content of present invention instruction, people in the art
Member can make various changes or modifications to the present invention, and these equivalent form of values equally fall within the application appended claims and limited
Scope.
Embodiment 1
Weigh 0.167gpnipaam and 0.333gec respectively with electronic analytical balance, the mixture of the two is dissolved in 2 milliliters
In dehydrated alcohol, under room temperature, magnetic agitation, to being completely dissolved (in solution, the mass ratio of pnipaam and ec is 1: 2), obtains concentration
Electrospinning liquid for 25% (grams per milliliter)；Electrospinning liquid is carried out on electrostatic spinning apparatus spinning, wherein voltage is 13 kilovolts, note
Emitter fltting speed is 0.5 ml/hour, accepts distance for 15 centimetres, from No. 9 syringe needles, is received with aluminium-foil paper, obtain
Size is the pnipaam/ec mixing nano fibrous membrane of 10 centimetres of 10 cm x.
Embodiment 2
Weigh 0.125gpnipaam and 0.375gec respectively with electronic analytical balance, the mixture of the two is dissolved in 2 milliliters
In dehydrated alcohol, under room temperature, magnetic agitation, to being completely dissolved (in solution, the mass ratio of pnipaam and ec is 1: 3), obtains concentration
Electrospinning liquid for 25% (grams per milliliter)；Electrospinning liquid is carried out on electrostatic spinning apparatus spinning, wherein voltage is 13 kilovolts, note
Emitter fltting speed is 0.5 ml/hour, accepts distance for 15 centimetres, from No. 9 syringe needles, is received with aluminium-foil paper, obtain
Size is the pnipaam/ec mixing nano fibrous membrane of 10 centimetres of 10 cm x.
Embodiment 3
Weigh 0.100gpnipaam and 0.400gec respectively with electronic analytical balance, the mixture of the two is dissolved in 2 milliliters
In dehydrated alcohol, under room temperature, magnetic agitation, to being completely dissolved (in solution, the mass ratio of pnipaam and ec is 1: 4), obtains concentration
Electrospinning liquid for 25% (grams per milliliter)；Electrospinning liquid is carried out on electrostatic spinning apparatus spinning, wherein voltage is 13 kilovolts, note
Emitter fltting speed is 0.5 ml/hour, accepts distance for 15 centimetres, from No. 9 syringe needles, is received with aluminium-foil paper, obtain
Size is the pnipaam/ec mixing nano fibrous membrane of 10 centimetres of 10 cm x.
Claims (5)
1. a kind of electro-spinning is for the method for poly- n- N-isopropylacrylamide and ethyl cellulose mixing nano fibrous membrane, comprising:
The mixture of poly- n- N-isopropylacrylamide and ethyl cellulose is dissolved, is obtained electrostatic spinning liquid, carried out electrostatic
Spinning, obtains final product the mixing nano fibrous membrane of poly- n- N-isopropylacrylamide/ethyl cellulose；Wherein, poly- n- isopropyl acrylamide
Amine is 1:1-4 with the mass ratio of ethyl cellulose；Wherein, electrostatic spinning process parameter is, voltage 10-15 kilovolt, receiving range
120-200 millimeter, syringe fltting speed is 0.1-1.0 ml/hour.
2. a kind of electro-spinning according to claim 1 mixes nanometer for poly- n- N-isopropylacrylamide with ethyl cellulose
The method of fibrous membrane it is characterised in that: the poly- n- N-isopropylacrylamide of described dissolving with the solvent of ethyl cellulose mixture is
Dehydrated alcohol.
3. a kind of electro-spinning according to claim 1 mixes nanometer for poly- n- N-isopropylacrylamide with ethyl cellulose
The method of fibrous membrane it is characterised in that: described poly- n- N-isopropylacrylamide with the concentration of ethyl cellulose mixed solution is
25% grams per milliliter.
4. a kind of electro-spinning according to claim 1 mixes nanometer for poly- n- N-isopropylacrylamide with ethyl cellulose
The method of fibrous membrane it is characterised in that: the mass ratio of described poly- n- N-isopropylacrylamide and ethyl cellulose be 1:2,1:3 or
1:4.
5. a kind of electro-spinning according to claim 1 mixes nanometer for poly- n- N-isopropylacrylamide with ethyl cellulose
The method of fibrous membrane it is characterised in that: the mixing nano fibrous membrane of described preparation is 10*10cm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410397888.7A CN104264372B (en) | 2014-08-13 | 2014-08-13 | Method for preparing PNIPAAm (poly(N-isopropylacrylamide)) and EC (ethyecellulose) blended nano-fiber membrane by electrostatic spinning |
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| CN201410397888.7A CN104264372B (en) | 2014-08-13 | 2014-08-13 | Method for preparing PNIPAAm (poly(N-isopropylacrylamide)) and EC (ethyecellulose) blended nano-fiber membrane by electrostatic spinning |
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| CN104264372A CN104264372A (en) | 2015-01-07 |
| CN104264372B true CN104264372B (en) | 2017-01-25 |
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| CN105926080A (en) * | 2016-06-14 | 2016-09-07 | 东华大学 | Preparation method of thermo-sensitive PNIPAAm (ploy(N-isopropylacrylamide)/PVP (polyvinyl pyrrolidone) composite fibers |
| TWI821653B (en) * | 2021-04-15 | 2023-11-11 | 財團法人紡織產業綜合研究所 | Temperature-sensing and humidity-controlling fiber and fabricating method thereof |
| CN114507448B (en) * | 2022-02-15 | 2023-09-29 | 武汉利眠生物科技有限公司 | Sustained-release sleep-aiding microcapsule, preparation method thereof, magnetic therapy adhesive body containing same and magnetic therapy adhesive |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102031574A (en) * | 2011-01-19 | 2011-04-27 | 哈尔滨工业大学 | Electrostatic spinning equipment and method thereof for preparing one-dimensional ordered PAMPS (2-Acrylamide-2-methylpro panesulfonic acid)/PNIPAAm (Poly(N-Isoprolacrylamide)) micro-nanofibers |
| CN102277689A (en) * | 2011-07-21 | 2011-12-14 | 东华大学 | Device and method for preparing cellulose fibrous membrane with nanometer structure |
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| EP2324045A4 (en) * | 2008-08-05 | 2013-04-03 | Univ Cornell | Photo-crosslinked nucleic acid hydrogels |
| CN101704933B (en) * | 2009-10-29 | 2012-07-11 | 无锡中科光远生物材料有限公司 | Thermal response-type ultrafine fiber film material and preparation method thereof |
| CN103784394A (en) * | 2014-02-11 | 2014-05-14 | 凌春生 | Intelligent temperature-sensitive sustained-release gel and preparation method thereof |
| CN103865104B (en) * | 2014-02-21 | 2016-06-08 | 东华大学 | A kind of preparation method of core shell nanoparticles |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102031574A (en) * | 2011-01-19 | 2011-04-27 | 哈尔滨工业大学 | Electrostatic spinning equipment and method thereof for preparing one-dimensional ordered PAMPS (2-Acrylamide-2-methylpro panesulfonic acid)/PNIPAAm (Poly(N-Isoprolacrylamide)) micro-nanofibers |
| CN102277689A (en) * | 2011-07-21 | 2011-12-14 | 东华大学 | Device and method for preparing cellulose fibrous membrane with nanometer structure |
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