CN104257838A - Functional food for protecting gastric mucosa - Google Patents
Functional food for protecting gastric mucosa Download PDFInfo
- Publication number
- CN104257838A CN104257838A CN201410486390.8A CN201410486390A CN104257838A CN 104257838 A CN104257838 A CN 104257838A CN 201410486390 A CN201410486390 A CN 201410486390A CN 104257838 A CN104257838 A CN 104257838A
- Authority
- CN
- China
- Prior art keywords
- flavone
- shinyleaf yellowhorn
- lignum xanthoceratis
- mucosal lesion
- eluent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 235000013376 functional food Nutrition 0.000 title claims abstract description 13
- 210000001156 gastric mucosa Anatomy 0.000 title abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 35
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims abstract description 34
- 229930003944 flavone Natural products 0.000 claims abstract description 34
- 235000011949 flavones Nutrition 0.000 claims abstract description 34
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- 150000002212 flavone derivatives Chemical class 0.000 claims abstract description 32
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 21
- 244000248162 Xanthoceras sorbifolium Species 0.000 claims abstract description 18
- 235000009240 Xanthoceras sorbifolium Nutrition 0.000 claims abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 14
- 238000002360 preparation method Methods 0.000 claims abstract description 10
- 239000000706 filtrate Substances 0.000 claims abstract description 9
- 241001465754 Metazoa Species 0.000 claims abstract description 6
- 238000005238 degreasing Methods 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims abstract description 5
- 239000007864 aqueous solution Substances 0.000 claims abstract description 3
- 238000001914 filtration Methods 0.000 claims abstract description 3
- 238000002791 soaking Methods 0.000 claims abstract description 3
- 230000009854 mucosal lesion Effects 0.000 claims description 21
- 239000003480 eluent Substances 0.000 claims description 12
- 230000001681 protective effect Effects 0.000 claims description 9
- 238000004440 column chromatography Methods 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 230000008719 thickening Effects 0.000 claims description 2
- 238000002474 experimental method Methods 0.000 abstract description 3
- 206010061164 Gastric mucosal lesion Diseases 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 241000700159 Rattus Species 0.000 description 18
- 230000037396 body weight Effects 0.000 description 9
- 238000003304 gavage Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 230000001629 suppression Effects 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- -1 Flavone compound Chemical class 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000012895 Gastric disease Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 241000612118 Samolus valerandi Species 0.000 description 1
- 241001093760 Sapindaceae Species 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 241000408907 Xanthoceras Species 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- LUIGNPZNIFQHGQ-UHFFFAOYSA-L magnesium methanol diacetate Chemical compound CO.C(C)(=O)[O-].[Mg+2].C(C)(=O)[O-] LUIGNPZNIFQHGQ-UHFFFAOYSA-L 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
- 229960000620 ranitidine Drugs 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a preparation method of shinyleaf yellowhorn flavone and a protection function of the shinyleaf yellowhorn flavone to gastric mucosa. The preparation method comprises the following steps: crushing shells of shinyleaf yellowhorn into 5-20 meshes, degreasing, removing oil, soaking shell powder of the shinyleaf yellowhorn by an aqueous solution containing ethyl alcohol and methyl alcohol, and filtering; carrying out vacuum concentration on filtrate to form paste, passing the paste through a column for chromatography, collecting eluant, and concentrating and freeze-drying the eluant to obtain the shinyleaf yellowhorn flavone. Animal experiment results prove that the shinyleaf yellowhorn flavone has the function of protecting gastric mucosal lesion. Therefore, the shinyleaf yellowhorn flavone can be applied to preparing functional foods or medicaments with the function of protecting the gastric mucosal lesion.
Description
Technical field
The present invention relates to a kind of Lignum Xanthoceratis flavone preparation method and to mucosal lesion protective effect, belong to functional food or medicine field.
Background technology
Along with the quickening of modern society's rhythm of life, people bear society, the increasing pressure of psychology and work causes greatly that the incidence rate of gastric mucosa disease is corresponding to be increased.And allegro life style, nervous working and learning, and excessive drinking etc. causes the common cause of mucosal lesion.As the worldwide disease of one, no matter in developed country, or in developing country, its sickness rate is all high.It is reported, in Chinese society population, the people more than 10% suffers from gastric ulcer, and the people of about 25% suffers from various gastritis, national patients with gastric disease total number of persons 300,000,000 people nearly.Therefore, find the functional food factor of the mucosal lesion of efficient, low side effect or ingredient and become an important and urgent task.
Lignum Xanthoceratis belongs to Sapindaceae Lignum Xanthoceratis and belongs to, and being also referred to as civil official fruit, xanthoceras sobifolia bunge etc., is the woody seeds of the distinctive preciousness of China.Shinyleaf yellowhorn shell is very high containing flavone amount, and colorimetric determination reaches 7%.Flavone compound aboundresources and be easy to extract, extensively exist in the organ such as stem, leaf, flower, fruit of plant, be one group of polyphenols different on structures and characteristics, platymiscium secondary metabolite, the form mainly with free state or glycosides is stored in Vacuoles of Plants.Ma Jietao points out that in " Lipid-lowering activities of flavone compound and the progress of mechanism of action thereof " flavone has antioxidation, adjusting blood lipid, scavenging free radicals, the biological activity such as antibacterial, has certain prevention, alleviates even therapeutical effect to the disease such as diabetes, hyperlipidemia and complication thereof.But, not yet there is report with the functional food factor of the Lignum Xanthoceratis flavone mucosal lesion protective effect that is composition or health product or medicine at present.
Summary of the invention
The object of the present invention is to provide a kind of Lignum Xanthoceratis flavone preparation method and to mucosal lesion protective effect.
Technical scheme of the present invention is as follows:
Be a kind of Lignum Xanthoceratis flavone preparation method to be provided and to mucosal lesion protective effect, to it is characterized in that it is completed by the following step:
After shinyleaf yellowhorn shell is crushed to 5-20 order, degreasing degreasing, with containing ethanol 60%-70%, the aqueous solution soaking shinyleaf yellowhorn shell powder of methanol 5%-10%, wherein liquor capacity milliliter number is shinyleaf yellowhorn shell opaque amount grams 10-20 times, and lixiviate 120-240 minute at 70-75 DEG C, after filtration; Filtrate reduced in volume, wherein thickening temperature is that filtrate is condensed into paste and crosses column chromatography by 60-70 DEG C, 0.1-0.7 atmospheric pressure, and filler is X-5 macroporous resin, and eluent is 75% ethanol, collects eluent, and eluent is concentrated freeze-dried, obtains Lignum Xanthoceratis flavone;
Experimental result shows, Lignum Xanthoceratis flavone of the present invention has protective effect to mucosal lesion.Therefore Lignum Xanthoceratis flavone of the present invention can be applied to and prepare functional food or the medicine that mucosal lesion has protective effect.
Detailed description of the invention
Further describe the present invention by following examples, but scope of the present invention is not by any restriction of these embodiments.
Embodiment 1: the preparation of the functional food of auxiliary protection mucosal lesion
After defat, shinyleaf yellowhorn fruit shell is crushed to 5-20 order, with ethanol content 60%, and the solution 500mL of methanol content 20%, soak 50g shinyleaf yellowhorn shell powder, lixiviate 60 minutes at 70 DEG C, filter, add the alcoholic solution lixiviate 50 minutes of 85% again, filter, twice filtrate is merged; After under filtrate normal pressure, ethanol, water and methanol to about 100mL are removed in boiling, change concentrating under reduced pressure into, concentrating under reduced pressure condition is 70 DEG C, 0.1 atmospheric pressure.Cross column chromatography after being condensed into paste, filler is X-5 macroporous resin, and eluent is 75% ethanol, collects eluent, and eluent is concentrated freeze-dried, obtains Lignum Xanthoceratis flavone; Qualitative detection, Lignum Xanthoceratis flavonoids solution 0.5mL, adds equal-volume 1% magnesium acetate methanol solution, heat drying, and observing under uviol lamp has yellow fluorescence, is defined as Flavonoid substances.
Mixed with sodium carboxymethyl cellulose by Lignum Xanthoceratis flavone, in mixture, Lignum Xanthoceratis flavone mass ratio is 3.7-80%, can be used as functional food or the medicine of auxiliary protection mucosal lesion.
Embodiment 2: the preparation of the functional food of auxiliary protection mucosal lesion
After defat, shinyleaf yellowhorn fruit shell is crushed to 5-20 order, and with ethanol content 60%, solution 500 mL of methanol content 20%, soaks 50g shinyleaf yellowhorn shell powder, lixiviate 60 minutes at 70 DEG C, filters, then adds the alcoholic solution lixiviate 50 minutes of 85%, filters, twice filtrate is merged; After under filtrate normal pressure, ethanol, water and methanol to 100 mL are removed in boiling, change concentrating under reduced pressure into, concentrating under reduced pressure condition is 70 DEG C, 0.1 atmospheric pressure.Cross column chromatography after being condensed into paste, filler is X-5 macroporous resin, and eluent is 75% ethanol, collects eluent, and eluent is concentrated freeze-dried, obtains Lignum Xanthoceratis flavone;
Be dissolved in by Lignum Xanthoceratis flavone in 0.5-1% carboxymethylcellulose sodium solution, in solution, the concentration of Lignum Xanthoceratis flavone is 0.384-38.4mg/mL, can be used as functional food or the medicine of auxiliary protection mucosal lesion.
Embodiment 3: the functional food of the auxiliary protection mucosal lesion of system or medicine are studied mucosal lesion auxiliary protection function
1. experiment material and method
1.1 medicines and reagent
70% ethanol, CMC(sodium carboxymethyl cellulose) etc. be analytical reagent, ranitidine purchased from Hong Rentang pharmacy.The Lignum Xanthoceratis flavone of preparation in embodiment 1.
1.2 animal
SD rat 100-200g, male, resist purchased from Shandong, animal productiong licence SCXK (Shandong) 20130001.
1.3 experimental technique
1.3.1 animal grouping and model preparation
Animal is divided into six groups at random, often organizes 8 rats, 25 DEG C, 70% humidity.
Treatment group and experimental protocol are as follows in detail:
(1) reagent controls group.0,24,48,49 hours gavage 0.5%CMC 1mL, kill rat in 50 hours.
(2) ethanol group.0,24,48 hours gavage 0.5%CMC 1mL, 49 hours gavage 70% ethanol, dosage is 2mL/1000g rat body weight.Within 50 hours, kill rat.
(3) positive drug group.0,24,48 hours gavage ranitidines (50 mg/1000g rat body weight), 49 hours gavage 70% ethanol, dosage is 2mL/1000g rat body weight.Within 50 hours, kill rat.
(4) Lignum Xanthoceratis flavone low dose group.0,24,48 hours gavage compounds 1 once, and dosage is 1.2 mg/1000g rat body weights, 49 hours oral 70% ethanol, and dosage is 2 mL/1000g rat body weights, within 50 hours, kills rat.
(5) dosage group in Lignum Xanthoceratis flavone.0,24,48 hours gavage compounds 1 once, and dosage is 12 mg/1000g rat body weights, 49 hours oral 70% ethanol, and dosage is 2 mL/1000g rat body weights, within 50 hours, kills rat.
(6) Lignum Xanthoceratis flavone high dose group.0,24,48 hours gavage compounds 1 once, and dosage is 120 mg/1000g rat body weights, 49 hours oral 70% ethanol, and dosage is 2 mL/1000g rat body weights, within 50 hours, kills rat.
1.3.2 gastric mucosal damage index and mucosal lesion suppression ratio calculate
Put to death rat and get gastric mucosa tissue, with the naked eye observe the degree of impairment of gastric mucosa with magnifier, with reference to Guth standards of grading, calculate gastric mucosal damage index, it is 1 point that point-like damage or damage are less than 1 mm, wire damaged length 1 ~ 2 mm is 2 points, wire damaged length 2 ~ 3 mm is 3 points, wire damaged length 3 ~ 4 mm is 4 points, by that analogy, wherein damage width to be greater than 2 mm score values and to double, all score sums are gastric mucosal damage index, mucosal lesion suppression ratio=(model group damage index-administration group damage index)/model group damage index × 100%.
2. experimental result
Table 1 Lignum Xanthoceratis flavone is to mucosal lesion suppression ratio
| Sample | Mucosal lesion suppression ratio (%) |
| Positive drug group | 72.5±2.6 |
| Lignum Xanthoceratis flavone low dose group | 84.3±3.4 |
| Dosage group in Lignum Xanthoceratis flavone | 88.2±6.8 |
| Lignum Xanthoceratis flavone high dose group | 74.5±3.1 |
From table 1, when target compound dosage is respectively 0.9%, 9% and 90% of control drug group dosage, suppression ratio is respectively 116%, 122% and 103% of control drug group.Visible, the effect of target compound is more effective than positive drug.
Claims (3)
1. technical scheme of the present invention is as follows:
Be a kind of Lignum Xanthoceratis flavone preparation method to be provided and to mucosal lesion protective effect, to it is characterized in that it is completed by the following step:
After shinyleaf yellowhorn shell is crushed to 5-20 order, degreasing degreasing, with containing ethanol 60%-70%, the aqueous solution soaking shinyleaf yellowhorn shell powder of methanol 5%-10%, wherein liquor capacity milliliter number is shinyleaf yellowhorn shell opaque amount grams 10-20 times, and lixiviate 120-240 minute at 70-75 DEG C, after filtration; Filtrate reduced in volume, wherein thickening temperature is that filtrate is condensed into paste and crosses column chromatography by 60-70 DEG C, 0.1-0.7 atmospheric pressure, and filler is X-5 macroporous resin, and eluent is 75% ethanol, collects eluent, and eluent is concentrated freeze-dried, obtains Lignum Xanthoceratis flavone.
2. results of animal shows, Lignum Xanthoceratis flavone of the present invention has protective effect to mucosal lesion.
3. therefore Lignum Xanthoceratis flavone of the present invention can be applied to and prepares functional food or the medicine that mucosal lesion has protective effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410486390.8A CN104257838A (en) | 2014-09-23 | 2014-09-23 | Functional food for protecting gastric mucosa |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410486390.8A CN104257838A (en) | 2014-09-23 | 2014-09-23 | Functional food for protecting gastric mucosa |
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| Publication Number | Publication Date |
|---|---|
| CN104257838A true CN104257838A (en) | 2015-01-07 |
Family
ID=52149495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410486390.8A Pending CN104257838A (en) | 2014-09-23 | 2014-09-23 | Functional food for protecting gastric mucosa |
Country Status (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113616744A (en) * | 2021-09-01 | 2021-11-09 | 山西大学 | Preparation method and application of millet whole grain flavone active component |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102823873A (en) * | 2012-09-04 | 2012-12-19 | 山东理工大学 | Application of xanthoceras sorbifolia flavone to field of skin whitening and preparation method of xanthoceras sorbifolia flavone |
-
2014
- 2014-09-23 CN CN201410486390.8A patent/CN104257838A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102823873A (en) * | 2012-09-04 | 2012-12-19 | 山东理工大学 | Application of xanthoceras sorbifolia flavone to field of skin whitening and preparation method of xanthoceras sorbifolia flavone |
Non-Patent Citations (3)
| Title |
|---|
| 李宗友: "槲皮素和柚皮素对大鼠溃疡形成和胃分泌的作用", 《国外医学中医中药分册》 * |
| 王颖，姜生，孟大利，李宁: "文冠果的化学成分与生物活性研究进展", 《现代药物与临床》 * |
| 臧志和，曹丽萍，钟铃: "芦丁药理作用及制剂的研究进展", 《医药导报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113616744A (en) * | 2021-09-01 | 2021-11-09 | 山西大学 | Preparation method and application of millet whole grain flavone active component |
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Application publication date: 20150107 |