CN104257829A - Traditional Chinese medicine oral solution for treating fish putrid-skin diseases and preparation method of oral solution - Google Patents
Traditional Chinese medicine oral solution for treating fish putrid-skin diseases and preparation method of oral solution Download PDFInfo
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- CN104257829A CN104257829A CN201410559077.2A CN201410559077A CN104257829A CN 104257829 A CN104257829 A CN 104257829A CN 201410559077 A CN201410559077 A CN 201410559077A CN 104257829 A CN104257829 A CN 104257829A
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- chinese medicine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention relates to a traditional Chinese medicine oral solution for treating fish putrid-skin diseases and a preparation method of the oral solution. The traditional Chinese medicine oral solution is prepared from the following raw materials: rheum officinale, coptidis rhizome, cortex phellodendri, andrographis paniculata, radix astragali and radix angelicae, and can be the radix angelicae. The preparation method comprises the following steps: (1) grinding the raw materials to be 60-80-mesh, weighing the raw materials according to a formula ratio, and performing three-dimensional mixing to obtain traditional Chinese medicine powder; (2) adding the traditional Chinese medicine powder and 300-600 parts of water into an extraction tank, and soaking for 5-20 hours; (3) heating to 40-100 DEG C and extracting for 10-15 hours; (4) filtering and collecting medicinal liquid; (5) continuously adding 300-600 parts of water into the rest of medicine residues and extracting at 40-100 DEG C for 10-15 hours; (6) filtering to remove the medicine residues, combining extraction liquid, and performing reduced pressure concentration at 30-70 DEG C until the volume is 10%-20% of the original volume; (7) filling bottles to obtain the finished traditional Chinese medicine oral solution, wherein the volume of each bottle is 500 ml. The traditional Chinese medicine oral solution provided by the invention can be used for effectively treating the fish putrid-skin diseases, and has the effects of clearing heat and toxic materials, invigorating qi for consolidating superficies and removing toxic materials for promoting tissue regeneration.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, especially a kind ofly treat Chinese medicine oral liquid of fish skin fester disease and preparation method thereof.
Background technology
Primary disease main harm flathead, silver carp, from fingerling, adult fish until parent fish all can fall ill, in recent years, developed into important common frdquently encountered disease, comparatively serious to parent fish harm, and all there is this sick appearance in area of respectively breeding fish.After sick fish infects, often the delay long period does not heal, and has a strong impact on growth promoter and breeding, and what flower, silver carp infection rate had can up to 80%, and in recent years, Ctenopharyngodon idellus also has this disease to occur.Primary disease is visible all the year round, and with comparatively susceptible disease summer and autumn, 28-32 DEG C is its epidemic peak phase.
Focus mainly occurs in dorsal fin and the later torso portion of abdomeinal fin; Next is abdominal part both sides; It is anterior that minority occurs in fish body, and this torso portion later with dorsal fin is easy to injured relevant.There is circle, oval erythema in disease sites, like adding a cover red seal at fish body surface, therefore is stigmatosis before this; Scale subsequently in the middle of focus comes off, and downright bad epidermis rots, and exposes white corium; The scale of intralesional peripheral part is imbedded in downright bad epidermis, outer peripheral edge scale loosens, dermathemia inflammation, forms distinct profile, along with the development of the state of an illness, the diameter of focus expands and depth down gradually, form ulcer, even expose skeleton or internal organs time serious, sick fish swimming is slow, loss of appetite, eventually because dying of exhaustion.
Current fish skin fester disease has become one of principal disease that fish breeding industry faces, and its death rate of the onset is high, often causes huge economic loss.Therefore develop a kind of tcm product had no side effect and treat an urgent demand that this disease become clinical.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, provides a kind of good effect, no drug residue, safe and reliable treatment fish skin fester disease Chinese medicine oral liquid.
Another technical problem that the present invention will solve is: provide a kind of Chinese medicine formula for the treatment of fish skin fester disease.
Another technical problem that the present invention will solve is: the preparation method providing the oral liquid formulations of above-mentioned fish Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of fish skin fester disease, is prepared from by the raw material of following mass fraction: Radix Et Rhizoma Rhei 20-50 part, Rhizoma Coptidis 20-50 part, Cortex Phellodendri 20-50 part, Herba Andrographis 20-50 part, Radix Astragali 20-50 part, Radix Angelicae Dahuricae 20-50 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows:
Radix Et Rhizoma Rhei 40 parts, Rhizoma Coptidis 30 parts, Cortex Phellodendri 30 parts, Herba Andrographis 30 parts, the Radix Astragali 30 parts, the Radix Angelicae Dahuricae 30 parts.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
Further, the preparation method of the oral liquid formulations of said composition is: Chinese medicine powder is broken to 60-80 order by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 300-600 part water are put in extraction pot respectively, soak 5-20 hour; (3) be heated to 40-100 DEG C and extract 10-15 hour; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 300-600 part water, and 40-100 DEG C is extracted 10-15 hour; (6) excessively filter medicinal residues, merge extracted twice liquid, 30-70 DEG C is evaporated to original volume 10%-20%; (7) fill becomes bottle, and every bottle of 250ml, gets product.
The advantage that the present invention has and good effect are:
(1) the present invention is according to tcm theory, and scientific compatibility, remains the combined effect of Chinese medicinal formulae determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, through clinical verification determined curative effect, is a kind of green veterinary drug of nuisanceless, no drug residue.
(2) Chinese medicine ingredients that the present invention contains can effectively treat fish skin fester disease, and cure rate can reach more than 95%.This prescription has the effect that warming middle-Jiao and tonifying deficiency, relieving diarrhea with astringents, yang invigorating take off admittedly.
(3) pharmacology of each raw material of Chinese medicine of the present invention is:
Radix Et Rhizoma Rhei: the poison that purges heat, removing mass are stagnant, clots absorbing blood.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication.
Herba Andrographis: heat-clearing and toxic substances removing, removing heat from blood are subsided a swelling.
The Radix Astragali: benefiting QI for strengthening the superficies, promoting pus discharge and tissue regeneration strengthening.
The Radix Angelicae Dahuricae: dampness, detumescence, pain relieving.
In side, Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Phellodendri three medicine share, and are the classical prescription of using for reference treatise on Febrile Diseases SANHUANG XIEXIN TANG, can play the object of heat-clearing and toxic substances removing, dampness pathogenic fire purging, broken stagnant promoting the circulation of blood.Cleansing pathogenic fire in body becomes silted up malicious, is equipped with Herba Andrographis, the Radix Astragali, the Radix Angelicae Dahuricae, and while enhancing heat-clearing and toxic substances removing effect, can play the object of removing heat from blood, detumescence, promoting pus discharge and tissue regeneration strengthening, reach internal and external application, two merits finish in one.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
A Chinese medicine oral liquid for treatment fish skin fester disease, the parts by weight of each raw material are as follows: Radix Et Rhizoma Rhei 40 parts, Rhizoma Coptidis 30 parts, Cortex Phellodendri 30 parts, Herba Andrographis 30 parts, the Radix Astragali 30 parts, the Radix Angelicae Dahuricae 30 parts.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product.
Embodiment 2
A Chinese medicine oral liquid for treatment fish skin fester disease, the parts by weight of each raw material are as follows: Radix Et Rhizoma Rhei 30 parts, Rhizoma Coptidis 30 parts, Cortex Phellodendri 30 parts, Herba Andrographis 40 parts, the Radix Astragali 30 parts, the Radix Angelicae Dahuricae 30 parts.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product
Embodiment 3
A Chinese medicine oral liquid for treatment fish skin fester disease, the parts by weight of each raw material are as follows: Radix Et Rhizoma Rhei 30 parts, Rhizoma Coptidis 30 parts, Cortex Phellodendri 40 parts, Herba Andrographis 20 parts, the Radix Astragali 30 parts, the Radix Angelicae Dahuricae 40 parts.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product
Clinical trial
Experimental example:
Jiangsu aquatic farm, Qi Zhongjia, second two 5 mu of silver carp rearing pools, infect skin fester disease.There is oval erythema in clinical manifestation abdomeinal fin, the scale in the middle of focus comes off, and epidermis rots, and exposes white corium.Product obtained by embodiment 1 is used to the Qi Jia pool.Every bottle of three mu of waters surface of splashing, once a day, treat three days.Medication is salvaged disease fish on the 3rd day and is almost recovered, without dead.After drug withdrawal, do not occur repeatedly.The another second pool uses penicillin to coordinate betagen solution to splash, and continuous five days, fish for disease fish, 15% skin fester disease of still having an appointment is not fully recovered, and dead with 30-40 bar every day, and continue medication three days, jumpbogroup is fully recovered.
Experiment proves that product obtained by embodiment 1 subtracts effect fast, determined curative effect, not easily repeatedly.
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiments according to limited range, therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (7)
1. treat Chinese medicine oral liquid of fish skin fester disease and preparation method thereof for one kind, it is characterized in that: be prepared from by the raw material of following mass fraction: Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Phellodendri, Herba Andrographis, the Radix Astragali, the Radix Angelicae Dahuricae.
2. the Chinese medicine oral liquid for the treatment of fish skin fester disease according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
Radix Et Rhizoma Rhei 20-50 part, Rhizoma Coptidis 20-50 part, Cortex Phellodendri 20-50 part, Herba Andrographis 20-50 part, Radix Astragali 20-50 part, Radix Angelicae Dahuricae 20-50 part.
3. the Chinese medicine oral liquid for the treatment of fish skin fester disease according to claim 1 and 2, is characterized in that: this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
4. the Chinese medicine oral liquid for the treatment of fish skin fester disease according to claim 3, is characterized in that: described preparation can be oral liquid.
5. prepare a method for the Chinese medicine oral liquid for the treatment of fish skin fester disease as claimed in claim 4, it is characterized in that: preparation method is that Chinese medicine powder is broken to certain order number by (1), and take by formula ratio, three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, aqueous solution are put in extraction pot respectively, soak the regular hour; (3) be heated to uniform temperature, extract certain hour; (4) collecting by filtration extracting solution; (5) secondary adds a certain amount of water in medicinal residues, continues to extract certain hour at a certain temperature; (6) merge extracted twice liquid, be evaporated to certain volume at a certain temperature; (7) fill becomes bottle, gets product.
6. the preparation method of the Chinese medicine oral liquid for the treatment of fish skin fester disease according to claim 5, is characterized in that: described pulverizing order number is 60-80 order.
7. the preparation method of the Chinese medicine oral liquid for the treatment of fish skin fester disease according to claim 5, is characterized in that: the extracted twice time is 10-15 hour.
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CN201410559077.2A CN104257829A (en) | 2014-10-18 | 2014-10-18 | Traditional Chinese medicine oral solution for treating fish putrid-skin diseases and preparation method of oral solution |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105327305A (en) * | 2015-10-29 | 2016-02-17 | 青岛海之源智能技术有限公司 | Environment-friendly preparation treating betta splendens stigmatosis and preparation method thereof |
CN108143982A (en) * | 2018-01-11 | 2018-06-12 | 信阳农林学院 | For treating Chinese medicine composition of wealth bringing in fish nocardiasis and preparation method thereof |
-
2014
- 2014-10-18 CN CN201410559077.2A patent/CN104257829A/en active Pending
Non-Patent Citations (4)
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姬广闻等,: "《新编鱼病综合防治手册》", 30 April 2002, 中原农民出版社 * |
林选锋: "大水面养殖鲢鳙鱼肠炎病治疗一例", 《科学养鱼》 * |
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黄玉柳等,: "中草药在水产健康养殖中的应用", 《安徽农业科学》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105327305A (en) * | 2015-10-29 | 2016-02-17 | 青岛海之源智能技术有限公司 | Environment-friendly preparation treating betta splendens stigmatosis and preparation method thereof |
CN108143982A (en) * | 2018-01-11 | 2018-06-12 | 信阳农林学院 | For treating Chinese medicine composition of wealth bringing in fish nocardiasis and preparation method thereof |
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Application publication date: 20150107 |