CN104248694B - Pharmaceutical composition and pharmaceutical preparation and its application - Google Patents
Pharmaceutical composition and pharmaceutical preparation and its application Download PDFInfo
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- CN104248694B CN104248694B CN201410478289.8A CN201410478289A CN104248694B CN 104248694 B CN104248694 B CN 104248694B CN 201410478289 A CN201410478289 A CN 201410478289A CN 104248694 B CN104248694 B CN 104248694B
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Abstract
Pharmaceutical composition and pharmaceutical preparation and its application.The present invention relates to a kind of pharmaceutical composition, which contains following raw material：Toad clothing, frankincense, myrrh, elephant hide, dragon's blood, safflower, Radix Notoginseng, Borneolum, stereotyped writing ox, cuttlebone, pearl, grab earthworm and blackberry lily, wherein, relative to the toad clothing of 100 parts by weight, frankincense, myrrh, elephant hide, dragon's blood, the content of safflower are respectively 100 400 parts by weight, Radix Notoginseng, Borneolum, the content of stereotyped writing ox are respectively 100 500 parts by weight, cuttlebone, the content for grabbing earthworm are respectively 100 300 parts by weight, the content of pearl is 40 130 parts by weight, and the content of blackberry lily is 100 340 parts by weight；The invention further relates to the pharmaceutical preparation containing aforementioned pharmaceutical compositions；The invention further relates to pharmaceutical preparation to prepare the application in being used to treat the medicine that veins of lower extremity festers disease, pharmaceutical composition of the invention and its pharmaceutical preparation be used to treating veins of lower extremity fester disease when, cure rate is high, and evident in efficacy.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, and the pharmaceutical preparation containing the pharmaceutical composition, and the medicine system
The application of agent.
Background technology
Varix of lower limb at present is the most important disease of venous system, and most common disease in limb vessel disease
One of.
In order to be best understood from the generation of varix of lower limb and development, teiology and treatment basis it may first have to be familiar with
The dissection of superficial veins of lower limb and physiological status.
1st, wall of vein weakness and septal defect：Wall of vein is relatively weak, can be expanded under vein pressure effect, valve Dou Chu's
Expansion causes original vein valve without tight closure, occurs valve insufficiency, backflow of blood, due to valve depauperation or
Missing, it is impossible to which performance effectively prevents refluence from acting on, and causes to fall ill.
2nd, intravenous pressure holding raises long：Venous blood due to gravity, produces valve certain pressure, positive reason in itself
It will not cause damage to it under condition, but when intravenous pressure persistently raises, valve can bear overweight pressure, gradually relax,
Prolapse, be allowed to incompetence, this is more common in long-term standing work, heavy physical labour, gestation, chronic cough, prolonged constipation etc.
Crowd.
3rd, secondly age, gender：Since limbs vein pressure only reaches maximum pressure, youth in body length up to highest when side
Body is not high before phase, therefore vein bore is smaller, can prevent phlebectasia, suffers from serious varication so while having before 30 years old, but
Most of increased with the age, and wall of vein and valve gradually lose its tension force, and symptom aggravation forces patient to see a doctor.
Varication is common with women, may can induce or aggravate varication due to gestation.But in no pregnant female
Property, its incidence (man also higher than male：Female=1：3), its reason is probably that female pelvis is more roomy, and blood vessel structure is excessively curved
Song, makes when menstrual period, the gestational period and menopause that endopelvic vein increase is congested, and cirsoid another original easily occurs for the gestational period
Tension force because being due to gestational period four limbs superficial vein reduces, and makes it easier to expand, such case can be recovered in postpartum.
If superficial veins of lower limb varicose cannot efficiently control, late when can show varix of lower limb
Ulcer, varicose ulcer of lower extremity are common peripheral angiopathies, and incidence is up to 1%~2%, and ulcer is not cured or is cured throughout the year
After recur, be one of intractable diseases, the work and life to patient cause very big inconvenience, often the ulcer caused by varication
And see a doctor.But the Chinese medicine composition and its preparation of the disease can be effectively treated currently not yet.
Therefore, it is badly in need of a kind of pharmaceutical composition and its preparation for being capable of cure varicose vein of lower limb ulcer now.
The content of the invention
The purpose of the invention is to overcome in the prior art can not cure varicose vein of lower limb ulcer the defects of, there is provided
A kind of pharmaceutical composition, and the pharmaceutical preparation containing the pharmaceutical composition, and the application of the pharmaceutical preparation.
The present inventor has found that pharmaceutical composition contains following raw material under study for action：Toad clothing, frankincense, myrrh, as
Skin, dragon's blood, safflower, Radix Notoginseng, Borneolum, stereotyped writing ox, cuttlebone, pearl, grab earthworm and blackberry lily, wherein, relative to 100 weight
The toad clothing of part, frankincense, myrrh, elephant hide, dragon's blood, the content of safflower are respectively 100-400 parts by weight, Radix Notoginseng, Borneolum, eight
The content of stock ox is respectively 100-500 parts by weight, and cuttlebone, the content for grabbing earthworm are respectively 100-300 parts by weight, and pearl contains
Measure as 40-130 parts by weight, the content of blackberry lily is 100-340 parts by weight, by the pharmaceutical composition and contains the pharmaceutical composition
Pharmaceutical preparation be used to treating veins of lower extremity and fester disease, veins of lower extremity can be significantly improved and festered the cure rate of disease, and treated
Effect is notable.
Therefore, to achieve these goals, the present invention provides a kind of pharmaceutical composition, the pharmaceutical composition to contain following
Raw material：Toad clothing, frankincense, myrrh, elephant hide, dragon's blood, safflower, Radix Notoginseng, Borneolum, stereotyped writing ox, cuttlebone, pearl, grab earthworm
And blackberry lily, wherein, relative to the toad clothing of 100 parts by weight, frankincense, myrrh, elephant hide, dragon's blood, the content of safflower are respectively
100-400 parts by weight, Radix Notoginseng, Borneolum, the content of stereotyped writing ox are respectively 100-500 parts by weight, cuttlebone, the content for grabbing earthworm
Respectively 100-300 parts by weight, the content of pearl is 40-130 parts by weight, and the content of blackberry lily is 100-340 parts by weight.
Preferably, it is respectively relative to the toad clothing of 100 parts by weight, frankincense, myrrh, elephant hide, dragon's blood, the content of safflower
150-230 parts by weight, Radix Notoginseng, Borneolum, the content of stereotyped writing ox are respectively 150-260 parts by weight, cuttlebone, the content for grabbing earthworm
Respectively 140-270 parts by weight, the content of pearl is 60-100 parts by weight, and the content of blackberry lily is 170-260 parts by weight.
On the other hand, present invention also offers a kind of pharmaceutical preparation containing aforementioned pharmaceutical compositions.
The third aspect, is used to treating veins of lower extremity and festers the medicine of disease preparing present invention also offers said medicine preparation
Application in thing.
The present invention pharmaceutical composition and pharmaceutical preparation be treat veins of lower extremity fester disease when, Wen Jingtong can be played
Network, promoting blood circulation and breaking stagnation, swelling and pain relieving, the effect for restraining ulcer surface, can significantly improve veins of lower extremity and fester the cure rate of disease, and
It is evident in efficacy.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Embodiment
The embodiment of the present invention is described in detail below.It is it should be appreciated that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to limit the invention.
The present invention provides a kind of pharmaceutical composition, which contains following raw material：Toad clothing, frankincense, myrrh,
Elephant hide, dragon's blood, safflower, Radix Notoginseng, Borneolum, stereotyped writing ox, cuttlebone, pearl, grab earthworm and blackberry lily, wherein, relative to 100 weights
Measure the toad clothing of part, frankincense, myrrh, elephant hide, dragon's blood, the content of safflower are respectively 100-400 parts by weight, Radix Notoginseng, Borneolum,
The content of stereotyped writing ox is respectively 100-500 parts by weight, and cuttlebone, the content for grabbing earthworm are respectively 100-300 parts by weight, pearl
Content is 40-130 parts by weight, and the content of blackberry lily is 100-340 parts by weight.
Preferably, it is respectively relative to the toad clothing of 100 parts by weight, frankincense, myrrh, elephant hide, dragon's blood, the content of safflower
150-230 parts by weight, Radix Notoginseng, Borneolum, the content of stereotyped writing ox are respectively 150-260 parts by weight, cuttlebone, the content for grabbing earthworm
Respectively 140-270 parts by weight, the content of pearl are 60-100 parts by weight, and the content of blackberry lily is 170-260 parts by weight, Neng Goujin
One step improves veins of lower extremity and festers the cure rate of disease.
In the present invention, parts by weight refer in terms of the dry weight of each bulk pharmaceutical chemicals.
In the present invention, toad clothing alias：Toad shell, toad are sloughed off, i.e., Bufonidae animal (Veneum Bufonis) toad oneself is de-
Under epidermis.One toad can take off 10-40 skins for 1 year, and north-south climate is different, and environment differs and variant.
In the present invention, frankincense (OLIBANUM) is olive subject plant Boswellia carterii (Boswellia carterii Birdw)
And/or (such as Bao reaches Boswellia carterii Boswellia bhawdajiana Birdw. and wild Boswellia carterii Boswellia to congener
Neglecta M.Moore) bark exudation resin.Frankincense is in long avette drop emulsus, similar round particle or is bonded into size not
Deng irregular block, surface yellow-white is translucent, is there is yellow-white powder, deposits then color burn long, and matter is crisp, and heat is soft
Change, the plane of disruption has hyaloid or waxy gloss, has special fragrance, mildly bitter flavor.Mainly fried by the way that raw material are put in pot with slow boiling
Slightly see melting point to surface, slightly cool to obtain in yellow, taking-up；Or fry to surface dissolve when, spray rice vinegar, continue to fry to outer layer
Bright light is saturating, and taking-up cools to obtain.
In the present invention, myrrh (MYRRHA) for olive subject plant Chinese violet tree (Commiphora myrrha Engl.) and/or
The dry resin of congener (as breathed out Chinese violet tree Commiphora molmol Engl.).Natural myrrh is in irregular particle
Agglomerate.Surface yellowish-brown or rufous, nearly translucent portion are in brownish black, are there is yellow dust.Matter heavily fortified point is crisp, and the plane of disruption is not whole
Together, it is matt：There is special fragrance, bitter and micro-pungent.Gum opoponax coheres into what is differed in size more in irregular block and particle
Agglomerate, surface brown color to sepia is opaque, and matter is solid or loose, there is special fragrance, bitter and have stickiness.Mainly pass through
Tree is stabbed, resin is oozed out naturally by wound or crack mouth.Just it is yellowish white liquid, it is hard fades to rufous in atmosphere
Block, obtains after dry.
In the present invention, elephant hide be Elephantidae animal elephant skin, elephant (Elephas maximus L.) African elephant
(Elephas africanus Blumenbach) is distributed in India, Indonesia, Sri Lanka, Thailand, Burma, Ma Laixi
The ground such as sub- and Yunnan Province of China south.
In the present invention, dragon's blood is the resin in babassu Sanguis Draxonis fruit and rattan；Original shape state：Sanguis Draxonis, for many years
Raw evergreen liana, up to 10-20m, stem is by leaf sheath and all over raw spine, and pinnate compound leaf is in branch alternate, in lower part sometimes closely to life；
Leaflet alternate, wire lanceolar, is about 20-30cm, wide about 3cm, the sharp point of apex, base portion is narrow, and arteries and veins 3 goes out parallel；Petiole and rachis
Has sharp thorn, spadix, opens flaxen coronal flower, unisexuality, dioecism；Perianth 6, lines up 2 wheels；Male flower stamen 6, flower pesticide length
Taper；Female flower has parastamen 6, and gynoecium 1, ampuliform, ovary is slightly in ovate, and close by scale, style is short, 3 drastic crack of column cap.Fruit core
Fruit shape, ovate is spherical, footpath about 2-3cm, russet, has yellow scale, fruit includes the fluid resin of deep redness of the skin or complexion, often by under scale
Exudation, such as clot sample, 1, seed after doing.Medicinal material latin name：Resina Draconis, plant latin name：Daemonorops
draco Bl.。
In the present invention, safflower is the drying column cap of irides safron (Crocus sativus L.), is《In
Magnificent people's republic's pharmacopeia》Nineteen ninety version is recorded, morphological feature：Perennial herb plant, no aerial stem of plant.Underground bulb is in
Oblate spheroid, hypertrophy are surrounded like onion bulb, appearance by several layers of brown film quality scales, and interior is milky entity meat, has a plurality of brown
Link, on section sprout, each bud is terminal bud (main bud) 1-4, big and obvious by multilayer film quality scale, positioned at bulb top, side
Bud is more and small, is distributed on each section.Leafage gives birth to, and linear, stockless is 15-45 centimetres long, accidental more than 50 centimetres, wide 0.2-0.4
Centimetre, apex is sharp, smooth, full edge, and cross section is in warp shape, and every plant 2-13 clumps, every clump has 2-15 piece leaves, and base portion has 3-5 pieces
Translucent scale.Flower basidixed, 4-6 centimetres of diameter, 6, perianth, obovate, lavender, thin tube-like, stamen 3, flower pesticide is big, yellow
Color, base portion flechette-type, gynoecium 1, carpel symphysis, ovary is the next, and style is elongated, faint yellow, 3 drastic crack of column cap, expands in funnel-form, long
2-3 centimetres, stretch out outside cylinder, sagging, peony is glossy, has special fragrance.
In the present invention, Radix Notoginseng be panax araliaceae plant root, plant latin name：Panax notoginseng
(Burk.)F.H.Chen ex C.Chow[P.pseudo-ginseng Wall.Vart.Notoginseng(Burk.)Hoo et
Tseng], harvesting and storage：General plantation harvests for 4 years, and " in the spring seven ", quality is good, and yield is high, and November harvests for the title that the 8-9 months harvest
Title " in the winter seven ", of poor quality, production is low.The root tuber dug, cleans soil, places by size, and solarization or fire dry (36-38 DEG C) 2-
3d, about sixty percent it is dry when, by supporting root, fibrous root, rhizome is cut respectively, then respectively carry out solarization or fire dry 2-3d, rubbed or put
Enter in rotating cylinder and roll, make its rubs mutually, take out and shine or dry again, 4-5 times repeatedly, a little Chinese alpine rush or Semen phaseoli radiati can be added last 1 time,
Until the smooth rounding of root tuber, parches to obtain the final product.
Phytomorph is：Perennial herb, up to 30-60cm, rhizome is short, has old stem remaining trace；The sturdy meat of root,
Inverted conical or short cylindrical shape, are about 2-5cm, diameter about 1-3cm, there is several supporting roots, crust yellow green to brown color, and stem is straight
It is vertical, it is bordering on cylinder；Glabrous, green or with the thin vertical stripe of most purples, palm volt compound leaf, 3-4 pieces of wheel is born in stem end；Petiole
Elongated, surface is hairless；3-7 pieces of leaflet；Vanelets ellipse is about 5-14cm, wide 2-5cm, central number to long round shape obovate
Piece is larger, most lower 2 minimums, and apex length point, base portion subcircular or both sides are unbecoming, and there is serration at edge, and increment occasionally has spinule
There is spinelet hair on hair, surface along the pulse, and two sides is bordering on hairless sometimes；Has petiolule.Total bennet is extracted out from stem end petiole center, directly
It is vertical, long 20-30cm；The independent basidixed of umbel, diameter about 3cm；Majority is spent, both sexes, unisexual flower and hermaphrodite flower coexist sometimes；It is small
Bennet is carefully short, and base portion has flakey bract；Calyx green, usual 5 fissure of apex；Petal 5, long round shape is avette, apex point, yellow
Green；Stamen 5, flower pesticide ellipse, medicine carries life, interior linear to lobe, filigree；Gynoecium 1, ovary is the next, and Room 2, spend 2 pieces,
Base portion symphysis, floral disc is flat or nick；Drupe berry shape, is bordering on kidney shape, is about 6-9mm；It is green when tender.It is red when ripe, seed
It is 1-3, spherical, kind skin white.The month at florescence 6-8；The fruiting period 8-10 months.
In the present invention, Borneolum is fresh for canella Borneolum tree (Typus physiologions Cinnanloni.)
Branches and leaves, through steam distillation, collect gold-plating and go out liquid, the crystallization of precipitation.It is the powdered crystallization of white translucent；Gas delicate fragrance, acrid flavour,
It is cool；Have volatility, light generation black smoke, and the flame with yellow.
In the present invention, stereotyped writing ox is rutaceae shaggy-fruited dittany and the root skin of Dictamnus angustifolius.Medicine latin name：Dictamni
Cortex。
In the present invention, cuttlebone is Sepiidae animal sepiella maindroni de Rochebrune (Sepiella maindroni de Rochebrune)
Or the drying inner casing of golden cuttlefish (Sepia esculenta Hoyle).Collect the bone-shaped inner casing of cuttlefish fish, cleaning, drying.
In the present invention, pearl is Pteriidae animal Hepu mother shellfish, nacre, large nacre, Pinctada chemnitzi or Unionidae
The pearl of the stimulated formation of outer embrane in the shells such as animal hydriopsis cumingii, cristaria plicata, anodonta woodiana pacifica.Latin name：
Pernulo。
In the present invention, the root tuber that earthworm climbs up by holding on to lucid asparagus for liliaceous plant is grabbed.Plant latin name：
Asparagusbrachyphylus Turcz.。
In the present invention, blackberry lily is irides blackberry lily (scientific name：Belamcanda chinensis (L.) Redout é)
Root-like stock, blackberry lily are perennial herb, and root-like stock is irregular bulk, is tiltedly stretched, yellow or yellowish-brown；Fibrous root is most, and band is yellow
Color, stem is upright, and stem is 1-1.5 meters high, solid.
In the present invention, it is above-mentioned it is raw materials used commercially available can cook can also conventionally process.
In the present invention, the form of pharmaceutical composition does not have special restriction, as long as the form of pharmaceutical composition can be easy to
External application, such as can be powder and/or particle, in order to enable pharmaceutical composition and its pharmaceutical preparation external skin ulcer surface
When, it can more fully contact with the ulcer surface, preferably be absorbed by the skin, it is preferable that described pharmaceutical composition is powder, should
The particle mean size of powder is 80-120 mesh.
The pharmaceutical composition of the present invention can be made by the way that above-mentioned various raw materials are mixed.As long as the condition of mixing makes respectively
Kind raw material ratio according to the invention is uniformly mixed.
Herein it should be noted that after above-mentioned various raw material content ranges according to the invention can be mixed in the present invention
Preferable particle size range is ground into the present invention again, will can also in advance be ground to the various raw materials of particle size range of the present invention
Proportioning according to the invention is mixed to get.Wherein, the raw material or pharmaceutical composition are ground to the method for 80-120 mesh
It can be the Chinese medicine Ginding process of this area routine, can also include shining above-mentioned each raw material or pharmaceutical composition before the grinding
It is dry.
On the other hand, present invention also offers a kind of pharmaceutical preparation, the pharmaceutical preparation to contain aforementioned pharmaceutical compositions.
Pharmaceutical preparation according to the present invention, wherein, there is no special restriction, the medicine to the formulation of pharmaceutical preparation
As long as preparation contains aforementioned pharmaceutical compositions and can be used in external application, such as the pharmaceutical preparation can be powder, when for dissipate
During agent, it should be appreciated by those skilled in the art can directly use aforementioned pharmaceutical compositions as powder.
Pharmaceutical preparation according to the present invention, wherein, which can also be paste, when for paste when, the cream
Agent can contain aforementioned pharmaceutical compositions and auxiliary material.On the basis of the gross weight of the paste, the content of described pharmaceutical composition is
10-90 weight %, the content of the auxiliary material is 10-90 weight %, wherein, the auxiliary material can be this area routine for making
The auxiliary material of standby paste, such as can be vaseline.The preparation method of paste can be this area it is conventional be used to prepare paste
Method.Such as it can include mixing pharmaceutical composition and auxiliary material.
The temperature of the mixing can be 100-130 DEG C, and the time of mixing can be 10-60 minutes.
The third aspect, is used to treating veins of lower extremity and festers the medicine of disease preparing present invention also offers said medicine preparation
Application in thing.
In actual use, for adult, in terms of pharmaceutical composition, dosage is daily 2 to the pharmaceutical preparation of the present invention
It is secondary, each 0.5-3g,
The present invention pharmaceutical composition and its pharmaceutical preparation be used for treat veins of lower extremity fester disease when, Wen Jing can be played
Dredging collateral, promoting blood circulation and breaking stagnation, swelling and pain relieving, the effect for restraining ulcer surface, fester the controlling of disease so as to significantly improve veins of lower extremity
More rate.
In the present invention, cure rate refers in each treatment group that symptom is wholly absent the number substantially mitigated with symptom and accounts for this and controls
The ratio for the treatment of group total treatment numbers.
Embodiment
In the following Examples and Comparative Examples, the processing method of raw material used is as follows：
Respectively by commercially available toad clothing, frankincense, myrrh, elephant hide, dragon's blood, safflower, Radix Notoginseng, Borneolum, stereotyped writing ox, sea Piao
Octopus, pearl, grab earthworm and blackberry lily dry after grind, and screened with the sieve of 100 mesh, select the screenings of each raw material to be used to prepare
The pharmaceutical composition of the present invention.
Cure rate refers in each treatment group that symptom is wholly absent the number substantially mitigated with symptom and accounts for the treatment group and always controls
The ratio for the treatment of number.
Embodiment 1-4
Embodiment 1-4 is used for the pharmaceutical composition for illustrating the present invention
Each raw material is mixed according to the dosage (being in parts by weight) shown in table 1, pharmaceutical composition A 1-A4 is made respectively.
Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Comparative example 1 | Comparative example 2 | |
| Pharmaceutical composition is numbered | A1 | A2 | A3 | A4 | D1 | D2 |
| Toad clothing | 100 | 100 | 100 | 100 | 0 | 100 |
| Frankincense | 150 | 180 | 230 | 400 | 150 | 150 |
| Myrrh | 150 | 180 | 230 | 400 | 150 | 150 |
| Elephant hide | 150 | 190 | 230 | 100 | 150 | 0 |
| Dragon's blood | 150 | 170 | 230 | 400 | 150 | 150 |
| Safflower | 150 | 170 | 230 | 400 | 150 | 150 |
| Radix Notoginseng | 150 | 200 | 260 | 500 | 150 | 150 |
| Borneolum | 150 | 150 | 260 | 100 | 150 | 150 |
| Stereotyped writing ox | 150 | 160 | 260 | 100 | 150 | 150 |
| Cuttlebone | 140 | 200 | 270 | 100 | 140 | 140 |
| Pearl | 60 | 80 | 100 | 130 | 60 | 0 |
| Grab earthworm | 140 | 200 | 270 | 100 | 140 | 140 |
| Blackberry lily | 170 | 200 | 260 | 100 | 170 | 170 |
Comparative example 1-2
Each raw material is mixed according to the dosage (being in parts by weight) shown in table 1, pharmaceutical composition D1-D2 is made.
Embodiment 5-10
Embodiment 5-10 is used to illustrate powder provided by the invention.
Pharmaceutical composition D1-D2 made from pharmaceutical composition A 1-A4 made from embodiment 1-4 and comparative example 1-2 is direct
Used as powder, which is renumbered as B1-B6；
Embodiment 11-16
Embodiment 11-16 is used to illustrate paste provided by the invention.
Vaseline is heated to 110 DEG C, then respectively by the embodiment 1-4 pharmaceutical composition A 1-A4 prepared and comparative example
Pharmaceutical composition D1-D2 prepared by 1-2 is added in vaseline, is endured at 110 DEG C 20 minutes, up to paste C1-C6.
Wherein, on the basis of the gross weight of the paste：
The content of A1 is 50 weight % in embodiment 11, and the content of vaseline is 50 weight %；
The content of A2 is 70 weight % in embodiment 12, and the content of vaseline is 30 weight %
The content of A3 is 30 weight % in embodiment 13, and the content of vaseline is 70 weight %
The content of A4 is 50 weight % in embodiment 14, and the content of vaseline is 50 weight；
The content of D1 is 50 weight % in embodiment 15, and the content of vaseline is 50 weight %.
The content of D2 is 50 weight % in embodiment 16, and the content of vaseline is 50 weight %.
Experimental example
Experimental example is used to illustrate pharmaceutical composition provided by the invention and its effect of preparation.
(1) 120 men and women patient's (male to female ratios 1 with different degrees of varix of lower limb always rotten lower limb are selected:1).
6 groups are randomly divided into, every group of 20 people.Topical administration, rotten position, lid last layer plastics are sprayed on by powder B1-B6 along vein trend
Cloth or bandage are fixed, and daily dressing 2 times, each dosage is 3g.Observing effect after medication 8 days.
Curative effect judging standard：Compared with before medication, the healing completely of ulceration face is wholly absent for symptom, labeled as zero, blood vessel
Elasticity is recovered, inflammation eliminates and ulceration face is reduced to symptom and substantially mitigates, and labeled as △, ulceration face area is not changed into symptom without bright
It is aobvious to improve, labeled as ×, the therapeutic effect of 6 treatment groups is as shown in table 2.
Table 2
(2) 150 men and women patient's (male to female ratios 1 with different degrees of varix of lower limb always rotten lower limb are selected:2).
6 groups are randomly divided into, every group of 25 people.Topical administration, rotten position, lid last layer plastics are sticked on by paste C1-C6 along vein trend
Cloth or bandage are fixed, and daily dressing 2 times, each dosage is 3g.Observing effect after medication 8 days.
Curative effect judging standard：Compared with before medication, the healing completely of ulceration face is wholly absent for symptom, labeled as zero, blood vessel
Elasticity is recovered, inflammation eliminates and ulceration face is reduced to symptom and substantially mitigates, and labeled as △, ulceration face area is not changed into symptom without bright
It is aobvious to improve, labeled as ×, the therapeutic effect of 6 treatment groups is as shown in table 3.
Table 3
Embodiment 1-4 is can be seen that compared with comparative example 1-2 from the measurement result of above experimental example, the medicine of embodiment 1-4
The preparation that compositions are prepared into for treat veins of lower extremity fester disease when, cure rate is high, evident in efficacy.
The cure rate that embodiment 1 can be seen that to embodiment 1 compared with embodiment 4 is above embodiment 4, therefore, works as phase
For the toad clothing of 100 parts by weight, frankincense, myrrh, elephant hide, dragon's blood, the content of safflower are respectively 150-230 parts by weight, drought
Pseudo-ginseng, Borneolum, the content of stereotyped writing ox are respectively 150-260 parts by weight, and cuttlebone, the content for grabbing earthworm are respectively 140-270 weights
Part is measured, the content of pearl is 60-100 parts by weight, when the content of blackberry lily is 170-260 parts by weight, can further improve lower limb
Vein festers the cure rate of disease.
The present invention pharmaceutical composition and its pharmaceutical preparation be used for treat veins of lower extremity fester disease when, Wen Jing can be played
Dredging collateral, promoting blood circulation and breaking stagnation, swelling and pain relieving, the effect for restraining ulcer surface, fester the controlling of disease so as to significantly improve veins of lower extremity
More rate.
The preferred embodiment of the present invention described in detail above, still, during present invention is not limited to the embodiments described above
Detail, in the range of the technology design of the present invention, a variety of simple variants can be carried out to technical scheme, this
A little simple variants belong to protection scope of the present invention.
It is further to note that each particular technique feature described in above-mentioned embodiment, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to it is various can
The combination of energy no longer separately illustrates.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should equally be considered as content disclosed in this invention.
Claims (9)
1. it is used to treating veins of lower extremity a kind of and festers the pharmaceutical composition of disease, it is characterised in that the pharmaceutical composition is by following
Raw material forms：Toad clothing, frankincense, myrrh, elephant hide, dragon's blood, safflower, Radix Notoginseng, Borneolum, stereotyped writing ox, cuttlebone, pearl, grab
Earthworm and blackberry lily, wherein, relative to the toad clothing of 100 parts by weight, frankincense, myrrh, elephant hide, dragon's blood, safflower content each
For 100-400 parts by weight, Radix Notoginseng, Borneolum, the content of stereotyped writing ox are respectively 100-500 parts by weight, and cuttlebone, grab containing for earthworm
Amount is respectively 100-300 parts by weight, and the content of pearl is 40-130 parts by weight, and the content of blackberry lily is 100-340 parts by weight.
2. pharmaceutical composition according to claim 1, wherein, relative to the toad clothing of 100 parts by weight, frankincense, myrrh, as
Skin, dragon's blood, the content of safflower are respectively 150-230 parts by weight, and Radix Notoginseng, Borneolum, the content of stereotyped writing ox are respectively 150-260
Parts by weight, cuttlebone, the content for grabbing earthworm are respectively 140-270 parts by weight, and the content of pearl is 60-100 parts by weight, blackberry lily
Content is 170-260 parts by weight.
3. pharmaceutical composition according to claim 1 or 2, wherein, described pharmaceutical composition is powder, and particle mean size is
80-120 mesh.
4. a kind of pharmaceutical preparation, it is characterised in that the pharmaceutical preparation contains the medicine group described in any one in claim 1-3
Compound.
5. pharmaceutical preparation according to claim 4, wherein, the pharmaceutical preparation is powder.
6. pharmaceutical preparation according to claim 4, wherein, the pharmaceutical preparation is paste.
7. pharmaceutical preparation according to claim 6, wherein, the paste also contains auxiliary material, using the gross weight of the paste as
Benchmark, the content of described pharmaceutical composition is 10-90 weight %, and the content of the auxiliary material is 10-90 weight %.
8. pharmaceutical preparation according to claim 7, wherein, the auxiliary material is vaseline.
9. pharmaceutical preparation in claim 4-8 described in any one is used to treating veins of lower extremity and festers the medicine of disease preparing
In application.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101347559A (en) * | 2008-07-02 | 2009-01-21 | 刘彦宾 | Medicament for treating ulcer of skin |
| EP1522314B1 (en) * | 2002-06-26 | 2014-03-05 | Ono Pharmaceutical Co., Ltd. | Remedies for diseases caused by vascular contraction or dilation |
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2014
- 2014-09-17 CN CN201410478289.8A patent/CN104248694B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1522314B1 (en) * | 2002-06-26 | 2014-03-05 | Ono Pharmaceutical Co., Ltd. | Remedies for diseases caused by vascular contraction or dilation |
| CN101347559A (en) * | 2008-07-02 | 2009-01-21 | 刘彦宾 | Medicament for treating ulcer of skin |
Non-Patent Citations (1)
| Title |
|---|
| 中西医结合治疗臁疮62例;吴月芝等;《河北中西医结合杂志》;19981231;第7卷(第2期);第239-240页,尤其是第240页右栏4体会项下 * |
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Effective date of registration: 20191223 Address after: 063000 No.136 Park Road, Fengrun District, Tangshan City, Hebei Province Patentee after: Jingshan Chinese medicine (Tangshan) Co. Ltd. Address before: 130032 Changchun Normal University hospital, Jilin, Changchun Co-patentee before: Sun Hao Patentee before: Jin Guang |