CN104237418A - Chromatographic instrument for making linearity curve without dilution and linearity curve measuring method - Google Patents
Chromatographic instrument for making linearity curve without dilution and linearity curve measuring method Download PDFInfo
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- CN104237418A CN104237418A CN201410534469.3A CN201410534469A CN104237418A CN 104237418 A CN104237418 A CN 104237418A CN 201410534469 A CN201410534469 A CN 201410534469A CN 104237418 A CN104237418 A CN 104237418A
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Abstract
The invention provides a chromatographic instrument for making a linearity curve without dilution and a linearity curve measuring method. The chromatographic instrument for making the linearity curve without dilution comprises a separation column, a pump and a six-way switching valve, wherein the separation column and the pump are respectively connected with the six-way switching valve. The chromatographic instrument for making the linearity curve without dilution also comprises a plurality of quantitative pipes and a selection valve which is used for selecting different quantitative pipes to be communicated with the six-way switching valve; the plurality of quantitative pipes are connected with the selection valve; the selection valve is connected with the six-way switching valve. According to the chromatographic instrument for making the linearity curve without dilution, the different quantitative pipes are selected by the selection valve to be used for detecting, the sizes of the quantitative pipes are different, the number of matter entering the separation column is changed through the different quantitative pipes to obtain a solution with different concentrations, operators prepare solutions with different concentrations to measure is not required during a measuring process, influences of linearity curve caused by container and man-made errors are effectively avoided, manpower-free solution dilution is achieved, the measuring accuracy of the chromatographic instrument for making the linearity curve without dilution is improved, and the work amount of the operators is reduced.
Description
Technical field
The present invention relates to chromatogram proving installation, particularly relate to and a kind ofly exempt to dilute the chromatograph and linearity curve measuring method of making linearity curve.
Background technology
Chromatograph application chromatography carries out the instrument of qualitative and quantitative analysis to material.As depicted in figs. 1 and 2, chromatograph of the prior art generally includes workstation 101, detecting device 102, detection cell 103, separating column 104, quantity tube 105 and six direction changeover valves 106, the two ends of quantity tube 105 are connected on two ports of six direction changeover valves 106, outside injector 108 is connected to six direction changeover valves 106, and leacheate container 107 is also connected on six direction changeover valves 106 by pump 1071.When Water demand, first, as shown in Figure 1, solution to be analyzed is injected in quantity tube 105 by six direction changeover valves 106 by injector 108, and too much solution enters into waste liquid barrel 109; After filling solution to be analyzed in quantity tube 105, as shown in Figure 2, six direction changeover valve 106 switching states, the leacheate that pump 1071 is carried enters into quantity tube 105 and the solution to be analyzed of quantity tube 105 is delivered to separating column 104, then under detection cell 103, detecting device 102 and workstation 101 analyze this CONCENTRATION STATE appearance time, the parameter such as peak height and peak area of solution.When doing stratographic analysis linearity curve, usually need the parameter value measuring multiple concentration point to obtain linearity curve, and due to the volume V of quantity tube 105 certain, must remove to change the quantity n entering into separating column 104 material, i.e. n=C*V by change material concentration C.But, linearity curve concentration point choose precision General Requirements at several ppb(μ g/L) to tens ppm(mg/L) and between and select at least 5 concentration point, and material drying and weigh, container scale and the error of material, the error of manual operation will affect the precision of linearly dependent coefficient, cause chromatograph measuring accuracy to reduce; And for the cleaning repeatedly of container and drying, the strength solution of the multiple concentration point needed for accurate formulation linearity curve, also significantly increases the workload of operating personnel.
Summary of the invention
Technical matters to be solved by this invention is: provide a kind of and exempt to dilute the chromatograph and linearity curve measuring method of making linearity curve, solve chromatograph in prior art and be affected by human factors the defect causing measuring accuracy to reduce, realize improving chromatographic measuring accuracy, reduce the workload of operating personnel.
Technical scheme provided by the invention is, a kind ofly exempt to dilute the chromatograph making linearity curve and comprise separating column, pump and six direction changeover valves, described separating column and described pump are connected with described six direction changeover valves respectively, also comprise many quantity tubes and the selector valve for selecting different described quantity tube to be communicated with described six direction changeover valves, many described quantity tubes are connected with described selector valve, and described selector valve is connected with described six direction changeover valves.
Further, described selector valve comprises stators and rotators, and the center of described stator is provided with the first connecting hole, and described stator Shang Raoqi center is provided with multiple second connecting hole, described stator is also provided with the 3rd connecting hole; The center of described rotor is provided with the first groove, described rotor is provided with arc-shaped slot, the second groove and the 3rd groove around its center, described second groove is communicated with formation first groove by the first link slot that described rotor is arranged with described first groove, and described 3rd groove is communicated with formation second groove by the second link slot that described rotor is arranged with described arc-shaped slot; Described rotor is attached on described stator, and described first groove is communicated with described first connecting hole, and described second groove is communicated with corresponding described second connecting hole with described 3rd groove, and described arc-shaped slot is communicated with described 3rd connecting hole; Many described quantity tubes are connected between two corresponding described second connecting holes, and described first connecting hole is connected with described six direction changeover valves with described 3rd connecting hole.
Further, described stator is provided with the auxiliary circle deep-slotted chip breaker be communicated with described 3rd connecting hole, the radius of described auxiliary circle deep-slotted chip breaker is identical with the radius of described arc-shaped slot, and described arc-shaped slot is communicated with described 3rd connecting hole by described auxiliary circle deep-slotted chip breaker.
Further, described stator is also fixedly connected with valve head, the center of described valve head is provided with the first external tapping, described valve head Shang Raoqi center is provided with multiple second external tapping, described valve head is also provided with the 3rd external tapping, described first external tapping is communicated with described first connecting hole, described second external tapping is communicated with corresponding described second connecting hole, described 3rd external tapping is communicated with corresponding described 3rd connecting hole, multiple described second external tapping is that divergent shape setting or multiple described second external tapping are distributed on the circumferential side wall of described valve head along the inside surface of described valve head to outside surface direction.
Further, described selector valve comprises stators and rotators, and described stator Shang Raoqi center is provided with two the first connecting holes and several second connecting holes; Described rotor is provided with the arc-shaped slot corresponding with described first connecting hole around its center, and described rotor is also provided with the groove corresponding with described arc-shaped slot and link slot, and described groove is communicated with described arc-shaped slot is formed groove structure by described link slot; Described rotor is attached on described stator, and described arc-shaped slot is communicated with corresponding described first connecting hole, and described groove is communicated with corresponding described second connecting hole; Many described quantity tubes are connected between two corresponding described second connecting holes, and two described first connecting holes are connected with described six direction changeover valves.
Further, described stator is provided with the auxiliary circle deep-slotted chip breaker corresponding with described first connecting hole, described auxiliary circle deep-slotted chip breaker is communicated with described first connecting hole, the radius of described auxiliary circle deep-slotted chip breaker is identical with the radius of corresponding described arc-shaped slot, and described arc-shaped slot is communicated with described first connecting hole by described auxiliary circle deep-slotted chip breaker.
Further, described stator is also fixedly connected with valve head, described valve head is provided with first external tapping corresponding with described first connecting hole, described valve head Shang Raoqi center is provided with the second external tapping corresponding to multiple and described second connecting hole, described first external tapping is communicated with corresponding described first connecting hole, described second external tapping is communicated with corresponding described second connecting hole, and multiple described second external tapping is that divergent shape setting or multiple described second external tapping are distributed on the circumferential side wall of described valve head along the inside surface of described valve head to outside surface direction.
Further, the center of circle of described second connecting hole is distributed in in the circular trace that is the center of circle of the center of described stator.
Further, described stator is provided with boss structure, described rotor is attached on the surface of described boss structure.
The present invention also provides a kind of linearity curve measuring method, adopts above-mentionedly to exempt to dilute the chromatograph making linearity curve and measure; Concrete grammar is: according to formula n=C*V, take C as constant, the quantity tube of different volumes is selected to be communicated with six direction changeover valves by selector valve, change enter into separating column material quantity to obtain the solution of variable concentrations, and then analyze obtain solution under variable concentrations parameter to draw out linearity curve; Wherein, C is material concentration, and V is the volume of quantity tube, and n is the quantity of material.
Provided by the inventionly exempt to dilute the chromatograph making linearity curve, different quantity tubes is selected to participate in detecting by adopting selector valve, the volume of each quantity tube is different, the quantity of separating column material can be entered into obtain the solution of variable concentrations by the change of different quantity tubes, namely according to formula n=C*V, take C as constant, take V as the parameter of solution under variable measurement variable concentrations, in measuring process, the solution modulating variable concentrations without the need to operating personnel is measured, and the solution of same concentration can be adopted in separating column, to obtain the solution of variable concentrations by different quantity tubes, effectively avoid the precision that container and people are the error effect linearity curve caused, realize the process of manpower-free's dilute solution, improve the chromatographic measuring accuracy of exempting to dilute and making linearity curve, decrease the workload of operating personnel.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is chromatographic structural representation one in prior art;
Fig. 2 is chromatographic structural representation two in prior art;
Fig. 3 is the structural representation one that the present invention exempts to dilute the chromatograph embodiment one making linearity curve;
Fig. 4 is the structural representation two that the present invention exempts to dilute the chromatograph embodiment one making linearity curve;
Fig. 5 is the assembling schematic diagram of stators and rotators in Fig. 3;
Fig. 6 is the structural representation of stator in Fig. 3;
Fig. 7 is the structural representation of Fig. 3 rotor;
Fig. 8 is two structural representations one that the present invention exempts to dilute the chromatograph embodiment making linearity curve;
Fig. 9 is two structural representations two that the present invention exempts to dilute the chromatograph embodiment making linearity curve;
Figure 10 is the assembling schematic diagram of stators and rotators in Fig. 8;
Figure 11 is the structural representation of stator in Fig. 8;
Figure 12 is the structural representation of Fig. 8 rotor;
Figure 13 is the structural representation that the present invention exempts to dilute selector valve in the chromatograph embodiment making linearity curve.
Embodiment
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with the accompanying drawing in the embodiment of the present invention, technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
As shown in Figure 3, the present embodiment exempts to dilute the chromatograph making linearity curve, comprise workstation 101, detecting device 102, detection cell 103, separating column 104, pump 401, many not isometric quantity tubes 106, six direction changeover valves 200 and waste liquid barrel 105, wherein, six direction changeover valves 200 are along the circumferential direction disposed with the first valve port, second valve port, 3rd valve port, 4th valve port, 5th valve port and the 6th valve port, separating column 104 is connected with the 3rd valve port of six direction changeover valves 200, the connection of waste liquid barrel 105 and the 5th valve port, the present embodiment is exempted to dilute the chromatograph making linearity curve and is also comprised selector valve 300 for selecting different basis weights pipe 106 to be communicated with six direction changeover valves 200, many not isometric quantity tube 106 correspondences are connected on selector valve 300, first valve port and the 4th valve port of selector valve 300 and six direction changeover valves 200 are connected.
Specifically, selector valve 300 in the present embodiment is connected with the first valve port and the 4th valve port for selecting different basis weights pipe 106, in test process, solution to be analyzed is injected into the present embodiment by the 6th valve port of six direction changeover valves 200 and exempts to dilute and do in the chromatograph of linearity curve by injector 500, and solution to be analyzed enters into certain buret 106 by six direction changeover valves 200 and selector valve 300; After quantity tube 106 fills solution to be analyzed, as shown in Figure 4, six direction changeover valve 200 switching states, leacheate is injected in six direction changeover valves 200 by pump 401 by leacheate container 400, leacheate enters into this quantity tube 106 by six direction changeover valves 200 and selector valve 300 and the solution to be analyzed of quantity tube 106 is delivered to separating column 104, is then analyzed appearance time, the parameter such as peak height and peak area of solution under this CONCENTRATION STATE by detection cell 103, detecting device 102 and workstation 101.Then, different quantity tubes 106 is selected again by selector valve 300, again perform above-mentioned steps, to obtain the appearance time of solution under another CONCENTRATION STATE, the parameter such as peak height and peak area, just can according to the many groups gain of parameter linearity curve accurately measured, when exempting to dilute the chromatograph making linearity curve by the present embodiment and carrying out linearity curve measurement, the solution of multiple variable concentrations is allocated without the need to operating personnel, effectively avoid the precision that container and people are the error effect linearity curve caused, realize the process of manpower-free's dilute solution, improve the chromatographic measuring accuracy of exempting to dilute and making linearity curve.Wherein, the present embodiment exempts to dilute the chromatograph making linearity curve can be ion chromatograph or liquid chromatograph.
Wherein, the selector valve 300 in the present embodiment can adopt various ways, below illustrates:
As shown in Fig. 3-Fig. 7, selector valve 300 comprises stator 1 and rotor 2, and the center of stator 1 is provided with the first connecting hole 11, and stator 1 Shang Raoqi center is provided with multiple second connecting hole 12, stator 1 is also provided with the 3rd connecting hole 13; The center of rotor 2 is provided with the first groove 21, rotor 2 is provided with arc-shaped slot 22, second groove 23 and the 3rd groove 24 around its center, second groove 23 is communicated with formation first groove the 201, three groove 24 by the first link slot 25 that rotor 2 is arranged with the first groove 21 and is communicated with formation second groove 202 by the second link slot 26 that rotor 2 is arranged with arc-shaped slot 22; Rotor 2 pastes on the stator 1, and the first groove 21 is communicated with the first connecting hole 11, and the second groove 23 is communicated with the second corresponding connecting hole 12 with the 3rd groove 24, and arc-shaped slot 22 is communicated with the 3rd connecting hole 13; Many quantity tubes 106 are connected between two corresponding the second connecting holes 12, and the first connecting hole 11 is connected with six direction changeover valve 200 first ports and the 4th port with the 3rd connecting hole 13 correspondence.Concrete, the first groove 201 and the second groove 202 will be followed rotor 2 and together be rotated, and the first groove 201 is communicated with the second corresponding connecting hole 12 with the second groove 202.Wherein, the first groove 201 that the first groove 21, first link slot 25 and the second groove 23 are formed is an integral channel structure, and the second groove 202 that arc-shaped slot 22, second link slot 26 and the 3rd groove 24 are formed is an integral channel structure.Rotor 2 is in rotation process, and the first groove 21 in the first groove 201 will be communicated with the first connecting hole 11 all the time, thus guarantees that the first connecting hole 11 can be communicated with second connecting hole 12 at diverse location place by the first groove 201; Meanwhile, arc-shaped slot 22 in second groove 202 can be communicated with the 3rd connecting hole 13 all the time, thus guarantee that the 3rd connecting hole 13 can be communicated with second connecting hole 12 at diverse location place by the second groove 202, realize selector valve 300 and can realize multiple mode of communicating, stator 1 can connect many quantity tubes 106 as required, and realize selecting specific quantity tube 106 to be connected with six direction changeover valves 200 as required.Such as: for the stator 1 in accompanying drawing 6, there are 12 the second connecting holes 12, then the stator 1 in accompanying drawing 6 can be connected with six roots of sensation quantity tube 106, thus realize six kinds of mode of communicating.Further, in order to reduce the friction force between stator 1 and rotor 2, stator 1 is provided with boss structure 10, the first connecting hole 11, second connecting hole 12 and the 3rd connecting hole 13 are distributed on the surface of boss structure 10, and rotor 2 is attached on the surface of boss structure 10.Concrete, boss structure 10 on stator 1 contacts with rotor 2, effectively reduce the contact area between rotor 2 and stator 1, after rotor 2 contacts with boss structure 10, seal up the groove structure on rotor 2 and the pore structure on stator 1 by the surface of contact between rotor 2 and boss structure 10.Preferably, the stator 1 in the present embodiment and rotor 2 can adopt polyetheretherketone (to be called for short: PEEK) high-abrasive material such as resin, nylon is made, and with more effective reduction friction factor, reduces wear.In addition, when selector valve 300 is for high-pressure valve, the first connecting hole 11, second connecting hole 12 in the present embodiment and the diameter of the 3rd connecting hole 13 can be 0.1mm ~ 1.5mm, the groove width of the first groove 201 and the second groove 202 can be 0.1mm ~ 1.5mm, and the groove depth of the first groove 201 and the second groove 202 can be 0.1mm ~ 1.5mm.Further again, in order to avoid there is the remaining liquid of the tail end of arc-shaped slot 22, stator 1 is provided with the auxiliary circle deep-slotted chip breaker 131 be communicated with the 3rd connecting hole 13, the radius of auxiliary circle deep-slotted chip breaker 131 is identical with the radius of arc-shaped slot 22, and arc-shaped slot 22 is communicated with the 3rd connecting hole 13 by auxiliary circle deep-slotted chip breaker 131.Concrete, rotor 2 is fitted on the stator 1, the tail end of arc-shaped slot 22 will overlap with auxiliary circle deep-slotted chip breaker 131, liquid in arc-shaped slot 22 will enter into the 3rd connecting hole 13 by auxiliary circle deep-slotted chip breaker 131, due in rotor 2 rotation process, the tail end of arc-shaped slot 22 will overlap with auxiliary circle deep-slotted chip breaker 131 all the time, avoids occurring the remaining liquid of the tail end of arc-shaped slot 22, improves the precision of selector valve 300.Preferably, the arc length of auxiliary circle deep-slotted chip breaker 131 is not less than the arc length of arc-shaped slot 22.
Same, shown in Fig. 8-Figure 12, selector valve 300 comprises stator 1 and rotor 2, the center of stator 1 is provided with the first connecting hole 11, stator 1 Shang Raoqi center is provided with two first connecting holes 11 and several second connecting holes 12, rotor 2 is provided with the arc-shaped slot 22 corresponding with the first connecting hole 11 around its center, rotor 2 is also provided with the groove 21 corresponding with arc-shaped slot 22 and link slot 23, and groove 21 is communicated with arc-shaped slot 22 by link slot 23 and forms groove structure 201; Rotor 2 pastes on the stator 1, and arc-shaped slot 22 is communicated with the first corresponding connecting hole 13, and groove 21 is communicated with the second corresponding connecting hole 12; Many quantity tubes 106 are connected between two corresponding the second connecting holes 12, and the first port and the 4th port of two the first connecting holes 11 and six direction changeover valves 200 are connected.Concrete, groove structure 201 will be followed rotor 2 and together be rotated, and groove structure 201 is communicated with the second corresponding connecting hole 12.Wherein, the groove structure 201 that groove 21, link slot 23 and arc-shaped slot 22 are formed is an integral channel structure.Rotor 2 is in rotation process, and groove structure 201 remains connected state by arc-shaped slot 22 with the first corresponding connecting hole 11, thus guarantees that this first connecting hole 11 can be communicated with second connecting hole 12 at diverse location place by groove structure 201; Meanwhile, another groove structure 201 is also communicated with second connecting hole 12 at corresponding diverse location place, realize selector valve 300 and can realize multiple mode of communicating, stator 1 can connect many quantity tubes 106 as required, and realize selecting specific quantity tube 106 to be connected with six direction changeover valves 200 as required.Such as: for the stator 1 in accompanying drawing 11, there are 12 the second connecting holes 12, then the stator 1 in accompanying drawing 11 can be connected with six roots of sensation quantity tube, thus realize six kinds of mode of communicating.Further, in order to reduce the friction force between stator 1 and rotor 2, stator 1 is provided with boss structure 10, the first connecting hole 11 and the second connecting hole 12 are distributed on the surface of boss structure 10, and rotor 2 is attached on the surface of boss structure 10.Concrete, boss structure 10 on stator 1 contacts with rotor 2, effectively reduce the contact area between rotor 2 and stator 1, after rotor 2 contacts with boss structure 10, seal up the groove structure on rotor 2 and the pore structure on stator 1 by the surface of contact between rotor 2 and boss structure 10.Preferably, the stator 1 in the present embodiment and rotor 2 can adopt polyetheretherketone (to be called for short: PEEK) high-abrasive material such as resin, nylon is made, and with more effective reduction friction factor, reduces wear.In addition, when selector valve 300 is for high-pressure valve, the first connecting hole 11 in the present embodiment and the diameter of the second connecting hole 12 can be 0.1mm ~ 1.5mm, and the groove width of groove structure 201 can be 0.1mm ~ 1.5mm, and the groove depth of groove structure 201 can be 0.1mm ~ 1.5mm.Further again, as shown in Figure 10-Figure 12, in order to avoid there is the remaining liquid of the tail end of arc-shaped slot 22, stator 1 is provided with the auxiliary circle deep-slotted chip breaker 111 be communicated with corresponding first connecting hole 11, the radius of auxiliary circle deep-slotted chip breaker 111 is identical with the radius of corresponding arc-shaped slot 22, and arc-shaped slot 22 is communicated with the first connecting hole 11 by auxiliary circle deep-slotted chip breaker 111.Concrete, rotor 2 is fitted on the stator 1, the tail end of arc-shaped slot 22 will overlap with auxiliary circle deep-slotted chip breaker 111, liquid in arc-shaped slot 22 will enter into the first connecting hole 11 by auxiliary circle deep-slotted chip breaker 111, due in rotor 2 rotation process, the tail end of arc-shaped slot 22 will overlap with auxiliary circle deep-slotted chip breaker 111 all the time, avoids occurring the remaining liquid of the tail end of arc-shaped slot 22, improves the precision of selector valve 300.Preferably, the arc length of auxiliary circle deep-slotted chip breaker 111 is not less than the arc length of arc-shaped slot 22 corresponding with it.
Wherein, as shown in figure 11, the center of circle of the second connecting hole 12 in the present embodiment is distributed in in the circular trace that is the center of circle of the center of stator 1, concrete, and the second connecting hole 12 is distributed in in the same circular trace that is the center of circle of the center of stator 1.Or, as shown in Figure 6, multiple second connecting hole is divided into multiple second connecting hole 1 and multiple second connecting hole 2 122, the center of circle of multiple second connecting hole 1 is distributed in the center of stator 1 as in the center of circle radius circular trace that is r1, the center of circle of multiple second connecting hole 2 122 is distributed in the center of stator 1 as in the center of circle radius circular trace that is r2, wherein, r1 is not equal to r2.And paste on the stator 1 in rotation process at rotor 2, the rotation of rotor 2, being centrally located on same straight line of the center of circle of arc-shaped slot 22 and stator 1.
As shown in figure 13, selector valve 300 can be motorized valve also can be hand valve, selector valve 300 does not limit its type of drive, in addition, selector valve 300 can be high-pressure valve, also can be low pressure valve, selector valve 300 does not limit its environment for use, selector valve 300 is described for the assembly relation of motorized valve to stator 1 and rotor 2, and the stator 1 in selector valve 300 and rotor 2 are arranged in shell 4 usually, and motor 5 drives rotor 2 to rotate.Further, stator 1 is also fixedly connected with valve head 3, the center of valve head 3 is provided with the first external tapping and/or the 3rd external tapping (not shown), valve head 3 Shang Raoqi center is provided with multiple second external tapping 31, second external tapping 31 is communicated with the second corresponding connecting hole 12, and multiple second external tapping 31 is that divergent shape setting or multiple second external tapping 31 are distributed on the circumferential side wall of valve head 3 along the inside surface of valve head 3 to outside surface direction.Concrete, second external tapping 31 is arranged in divergent shape on valve head 3, thus when blocking occurs appearance second connecting hole 12, fine needle can be adopted to be inserted in the second connecting hole 12 along the second external tapping 31 clear up, thus without the need to dismantling selector valve 300, the second connecting hole 12 blocked just can be cleared up easily.And the second external tapping 31 is distributed on the circumferential side wall of valve head 3, the xsect of the second external tapping 31 is L-type structure, more convenient processing.
The present invention also provides a kind of linearity curve measuring method, adopts above-mentionedly to exempt to dilute the chromatograph making linearity curve and measure; Concrete grammar is: according to formula n=C*V, take C as constant, the quantity tube of different volumes is selected to be communicated with six direction changeover valves by selector valve, change enter into separating column material quantity to obtain the solution of variable concentrations, and then analyze obtain solution under variable concentrations parameter to draw out linearity curve; Wherein, C is material concentration, and V is the volume of quantity tube, and n is the quantity of material.
Provided by the inventionly exempt to dilute the chromatograph and linearity curve measuring method of making linearity curve, select different quantity tubes to be connected with six direction changeover valves by adopting selector valve to participate in detecting, the volume of each quantity tube is different, the quantity of separating column material can be entered into obtain the solution of variable concentrations by the change of different quantity tubes, namely according to formula n=C*V, take C as constant, take V as the parameter of solution under variable measurement variable concentrations, in measuring process, the solution modulating variable concentrations without the need to operating personnel is measured, and the solution of same concentration can be adopted in separating column, to obtain the solution of variable concentrations by different quantity tubes, effectively avoid the precision that container and people are the error effect linearity curve caused, realize the process of manpower-free's dilute solution, improve the chromatographic measuring accuracy of exempting to dilute and making linearity curve, decrease the workload of operating personnel.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (5)
1. exempt to dilute the chromatograph making linearity curve for one kind, comprise separating column, pump and six direction changeover valves, described separating column and described pump are connected with described six direction changeover valves respectively, it is characterized in that, also comprise many quantity tubes and the selector valve for selecting different described quantity tube to be communicated with described six direction changeover valves, many described quantity tubes are connected with described selector valve, and described selector valve is connected with described six direction changeover valves; Described selector valve comprises stators and rotators, and described stator Shang Raoqi center is provided with two the first connecting holes and several second connecting holes; Described rotor is provided with the arc-shaped slot corresponding with described first connecting hole around its center, and described rotor is also provided with the groove corresponding with described arc-shaped slot and link slot, and described groove is communicated with described arc-shaped slot is formed groove structure by described link slot; Described rotor is attached on described stator, and described arc-shaped slot is communicated with corresponding described first connecting hole, and described groove is communicated with corresponding described second connecting hole; Many described quantity tubes are connected between two corresponding described second connecting holes, and two described first connecting holes are connected with described six direction changeover valves; Described stator is provided with the auxiliary circle deep-slotted chip breaker corresponding with described first connecting hole, described auxiliary circle deep-slotted chip breaker is communicated with described first connecting hole, the radius of described auxiliary circle deep-slotted chip breaker is identical with the radius of corresponding described arc-shaped slot, and described arc-shaped slot is communicated with described first connecting hole by described auxiliary circle deep-slotted chip breaker.
2. according to claim 1ly exempt to dilute the chromatograph making linearity curve, it is characterized in that, described stator is also fixedly connected with valve head, described valve head is provided with first external tapping corresponding with described first connecting hole, described valve head Shang Raoqi center is provided with the second external tapping corresponding to multiple and described second connecting hole, described first external tapping is communicated with corresponding described first connecting hole, described second external tapping is communicated with corresponding described second connecting hole, multiple described second external tapping is that divergent shape setting or multiple described second external tapping are distributed on the circumferential side wall of described valve head along the inside surface of described valve head to outside surface direction.
3. according to claim 1 and 2ly exempt to dilute the chromatograph making linearity curve, it is characterized in that, the center of circle of described second connecting hole is distributed in in the circular trace that is the center of circle of the center of described stator.
4. according to claim 1 and 2ly exempt to dilute the chromatograph making linearity curve, it is characterized in that, described stator is provided with boss structure, and described rotor is attached on the surface of described boss structure.
5. a linearity curve measuring method, is characterized in that, adopt as arbitrary in claim 1-9 as described in the chromatograph making linearity curve of exempting to dilute measure; Concrete grammar is: according to formula n=C*V, take C as constant, the quantity tube of different volumes is selected to be communicated with six direction changeover valves by selector valve, change enter into separating column material quantity to obtain the solution of variable concentrations, and then analyze obtain solution under variable concentrations parameter to draw out linearity curve; Wherein, C is material concentration, and V is the volume of quantity tube, and n is the quantity of material.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4158630A (en) * | 1978-02-24 | 1979-06-19 | Stearns Stanley D | Chromatographic multi-sample valving apparatus |
| WO2008140377A1 (en) * | 2007-05-15 | 2008-11-20 | Ge Healthcare Bio-Sciences Ab | Random access rotary valve |
| CN102333954A (en) * | 2009-02-27 | 2012-01-25 | 沃特世科技公司 | Automated dilution for liquid chromatography |
| CN102574026A (en) * | 2009-09-25 | 2012-07-11 | 通用电气医疗集团生物科学公司 | Separation system and method |
| CN102918309A (en) * | 2010-05-20 | 2013-02-06 | 生物辐射实验室股份有限公司 | Rotary column selector valve |
| CN102967681A (en) * | 2012-11-26 | 2013-03-13 | 中国科学院青岛生物能源与过程研究所 | Multi-dimensional ion chromatographic analysis system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3744219A (en) * | 1972-02-29 | 1973-07-10 | Us Interior | Multiple-loop chromatography system |
| US4476731A (en) * | 1983-03-03 | 1984-10-16 | Scientific Systems, Inc. | Injection valve for liquid chromatographic column and system therefor |
| US4625569A (en) * | 1984-01-17 | 1986-12-02 | Toyo Soda Manufacturing Co., Ltd. | Liquid injection device |
| JP4291628B2 (en) * | 2003-06-12 | 2009-07-08 | 株式会社資生堂 | Liquid chromatograph apparatus and method for analyzing optical isomers contained in sample |
| CN203465249U (en) * | 2013-09-11 | 2014-03-05 | 青岛普仁仪器有限公司 | Dilution-free linearity curve drawing chromatographic instrument |
| CN103439432B (en) * | 2013-09-11 | 2015-04-01 | 青岛普仁仪器有限公司 | Dilution-free linear curve chromatograph and linear curve measuring method |
-
2013
- 2013-09-11 CN CN201310413012.2A patent/CN103439433B/en active Active
- 2013-09-11 CN CN201410534469.3A patent/CN104237418B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4158630A (en) * | 1978-02-24 | 1979-06-19 | Stearns Stanley D | Chromatographic multi-sample valving apparatus |
| WO2008140377A1 (en) * | 2007-05-15 | 2008-11-20 | Ge Healthcare Bio-Sciences Ab | Random access rotary valve |
| CN102333954A (en) * | 2009-02-27 | 2012-01-25 | 沃特世科技公司 | Automated dilution for liquid chromatography |
| CN102574026A (en) * | 2009-09-25 | 2012-07-11 | 通用电气医疗集团生物科学公司 | Separation system and method |
| CN102918309A (en) * | 2010-05-20 | 2013-02-06 | 生物辐射实验室股份有限公司 | Rotary column selector valve |
| CN102967681A (en) * | 2012-11-26 | 2013-03-13 | 中国科学院青岛生物能源与过程研究所 | Multi-dimensional ion chromatographic analysis system |
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| Publication number | Publication date |
|---|---|
| CN103439433B (en) | 2015-06-10 |
| CN103439433A (en) | 2013-12-11 |
| CN104237418B (en) | 2015-11-18 |
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