CN104231167A - Preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite hydrogel - Google Patents
Preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite hydrogel Download PDFInfo
- Publication number
- CN104231167A CN104231167A CN201410467736.XA CN201410467736A CN104231167A CN 104231167 A CN104231167 A CN 104231167A CN 201410467736 A CN201410467736 A CN 201410467736A CN 104231167 A CN104231167 A CN 104231167A
- Authority
- CN
- China
- Prior art keywords
- graphene oxide
- hydroxyapatite
- solution
- preparation
- polyacrylamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a preparation method of hydroxyapatite (HA)/graphene oxide (GO)/polyacrylamide (PAM) composite hydrogel, and belongs to the field of high polymer materials. Hydroxyapatite (HA) and graphene oxide (GO) are prepared into a solution, and then are doped into a polyacrylamide (PAM) network structure. According to the method, the preparation process is simple and convenient to operate, the cost is saved, the problems that a polyacrylamide (PAM) bracket easily bends and the mechanical property is poor are overcome by the obtained composite material, and the characteristics that the graphene oxide (GO) is relatively low in cytotoxicity, and strong in drug-loading capacity, and the hydroxyapatite (HA) is good in biocompatibility are reserved. Therefore, the composite material can be used as a bone repair material, and has potential application value in tissue engineering.
Description
Technical field
The present invention relates to a kind of preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel, belong to technical field of polymer materials.
Background technology
Polyacrylamide (PAM) hydrogel, because having good bio-compatibility, causes the broad interest of biologic applications circle, biologic applications circle use it for organizational project the field such as timbering material, cartilaginous tissue equivalent material, pharmaceutical carrier (
j. P. Gong, Advanced MateriaLs, 2003,15,1155-1158).The hydrogel scaffold especially with some strength has been applied to the research and development of the products such as bone, cartilage and muscle.The intensity of hydrogel and the degree of crosslinking of gel and working conditions etc. thereof have certain relation.But general hydrogel is because the long-chain of extensively distribution forms random cross-linking set by traditional covalent cross-linking, lack effective energy dissipation mechanism, therefore it presents fragility, low ductility, low mechanical strength, practical application is very limited, therefore needs the mechanical property improving gelatinous material further.In the last few years, how to improve hydrogel mechanical property and develop the hydrogel with specific function become scientific circles and business circles research emphasis (
h. P. Cong, P. Wang, S. H. Yu. SmaLL,2014,10,448-453).
Hydroxyapatite (HA) matrix material has vital role in bone tissue engineer field, is regarded as the ideal chose of bone alternate material.Calcium phosphate (CP) is commonly used to the inorganic components simulating mineralising natural bone, and there is osteoinductive, therefore HA/CP matrix material simulation mineralising natural bone composition and in nature tool have great advantage, more existing research report HA stupalith is applied to bone tissue engineer.Graphene oxide sheet (GO) surface, with a large amount of hydrophilic acidic functional group, has good wettability and surfactivity, lower to cytotoxicity, and Drug loading capacity is strong, effectively can prevent the advantages such as failure.
Summary of the invention
The present invention aims to provide a kind of method preparing the hydroxyapatite/graphene oxide/polyacrylamide ternary bone renovating material with excellent mechanical property.This technology of preparing remains the advantage of hydroxyapatite and graphene oxide, enhances the mechanical property of polyacrylamide polymers single-material, has widened the application category of matrix material.This preparation method's process is simple, and the mechanical property of the hybridized hydrogel material of synthesis obtains significant raising.
The preparation method of a kind of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel provided by the invention, it is characterized in that: by hydroxyapatite (HA) and graphene oxide (GO) wiring solution-forming, then be doped in polyacrylamide (PAM) network structure, specifically comprise the following steps:
(1) prepare hydroxyapatite (HA) aqueous solution: hydroxyapatite (HA) powder is dissolved in intermediate water, and shake stirring and make it fully dissolve, namely obtain milky HA solution;
(2) preparation of graphene oxide (GO) solution: graphene oxide (GO) powder is dissolved in intermediate water, then shakes stirring and makes it fully dissolve, namely obtain the GO solution that black is bright;
(3) prepare linking agent (MBA) aqueous solution: get linking agent N, N'-methylene-bisacrylamide (MBA) is dissolved in the water, and ultrasonic vibration 2min makes Solution Dispersion even, namely obtains cross-linking agent aqueous solution;
(4) prepare initiator (KPS) aqueous solution: get initiator potassium persulfate (KPS) and be dissolved in the water, ultrasonic vibration 2min makes Solution Dispersion even, namely obtains initiator solution;
(5) preparation of HA/GO/ PAM composite aquogel: add monomeric acrylamide in test tube, getting cross-linking agent solution is added drop-wise in test tube, get above-mentioned (1) more respectively, solution that (2) obtain drips in test tube, and add intermediate water monomer whose is fully dissolved; Then test tube is sealed, add initiator and accelerator, initiated polymerization, react after carrying out 8-16h at 25 DEG C, namely prepare HA/GO/ PAM composite aquogel.
Further, described hydroxyapatite powder grain size is 0.04-12 μm, and gained strength of solution is 0.01-0.03g/mL.The concentration of described graphene oxide solution is 0.0005-0.005g/mL.Described initiator is Potassium Persulphate, and concentration is 0.005-0.01g/mL; Described linking agent is N, N'-methylene-bisacrylamide, and concentration is 0.001-0.005g/mL.
Described accelerator is N, N, N', N'-Tetramethyl Ethylene Diamine, and its density is 0.775g/mL, and the consumption of accelerator and the mass ratio of monomeric acrylamide are 7.75:1000.
Further, the mass ratio of described monomeric acrylamide, initiator, linking agent is (250 ~ 1500): 2.5:1; The mass ratio (0.1-0.5) of described hydroxyapatite, graphene oxide, monomeric acrylamide: (0.0005-0.005): (2-4).
The inventive method is first by hydroxyapatite (HA) and graphene oxide (GO) wiring solution-forming, then be doped in polyacrylamide (PAM) network structure, make a kind of excellent mechanical property that has, can be used as hydroxyapatite (HA)/graphene oxide (GO)/polyacrylamide (PAM) composite aquogel of cartilage replacement material.The present invention brings
beneficial effect:
On this basis above-mentioned hydroxyapatite (HA)/graphene oxide (GO) matrix material and polyacrylamide (PAM) graft copolymerization are obtained hydroxyapatite (HA)/graphene oxide (GO)/polyacrylamide (PAM) trielement composite material, enhance the mechanical property of its original polyacrylamide (PAM) hydrogel, remain respective biology and electrochemistry advantage, can be used as a kind of potential bone renovating material and be applied to bone tissue engineer.
(1) polyacrylamide is the cartilage replacement material that a kind of bio-compatibility is good, hydroxyapatite (HA) and graphene oxide (GO) material are mixed in polyacrylamide (PAM) hydrogel by hydrogen bond action, enhance the mechanical property of its original polyacrylamide (PAM) hydrogel, remain respective biology and electrochemistry advantage, can be used as a kind of potential bone renovating material and be applied to bone tissue engineer.The mechanical property of this trielement composite material is enhanced, and (when adding hydroxyapatite (HA) and graphene oxide (GO) mixing solutions in simple monomer-polymer, compression stiffness significantly increases, such as: be increased to 0.65 newton when compressing identical 2mm by 0.3 original newton), for the application of its multifunction provides a technology platform, it is made to be expected to as bone renovating material and to be applied to organizational project.
(2) graphene oxide is a kind of hardened material, and the present invention, by increasing the consumption of graphene oxide, enhances the Compressive Mechanical Properties of matrix material;
(3) the good tension of hydroxyapatite (HA), measuring body mechanical property is remained;
(4) the method preparation process is easy and simple to handle, cost-saving.
Accompanying drawing explanation
Fig. 1 is the load-displacement curves figure of the hydroxyapatite/graphene oxide/polyacrylamide compound hydrogel material compression of different ratio.
Fig. 2 is the load-displacement curves figure of the compound hydrogel material compression under different graphene oxide proportioning.
Embodiment
Further illustrate the present invention below by embodiment, but be not limited to following examples.
embodiment 1:the preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel
(1) prepare hydroxyapatite (HA) aqueous solution: 0.1g hydroxyapatite (HA) powder of 12 μm is dissolved in 5mL intermediate water, and shake stirring and make it fully dissolve, namely obtain the milky HA solution that concentration is 0.02g/mL;
(2) prepare graphene oxide (GO) aqueous solution: 0.01g graphene oxide (GO) powder is dissolved in 5mL intermediate water, then shake stirring and make its abundant rapid solution, namely obtaining concentration is the bright GO solution of 0.002g/mL black;
(3) prepare cross-linking agent aqueous solution (MBA): by 0.02g linking agent N, N'-methylene-bisacrylamide (MBA) is dissolved in 5mL intermediate water, and ultrasonic vibration 2min makes Solution Dispersion even, namely obtains the cross-linking agent aqueous solution that concentration is 0.004g/mL;
(4) prepare initiator solution (KPS): get 0.05g initiator potassium persulfate (KPS) and be dissolved in 5mL intermediate water, ultrasonic vibration 2min makes Solution Dispersion even, namely obtains the initiator solution that concentration is 0.01g/mL;
(5) preparation of HA/GO/ PAM composite aquogel: add monomeric acrylamide 2g in test tube, then taking 0.5mL cross-linking agent solution drips in test tube, the solution that (1), (2) that takes 1mL more respectively obtains drips in test tube, and add 3mL intermediate water concussion shake up, monomer whose is fully dissolved; Then test tube is sealed, add 0.5mL initiator and 0.02mL accelerator subsequently, initiated polymerization; After reaction carries out 12h at 25 DEG C, HA/GO/ PAM composite aquogel can be prepared.
Described accelerator is N, N, N', N'-Tetramethyl Ethylene Diamine (TEMED), and its density is 0.775g/mL.
Then, being cut into diameter is 13mm, and the high cylinder specimen for 20mm carries out compression performance test.The results are shown in Figure 1.
The testing tool used in the present invention is Ai Debao pointer-type pull and push dynamometer NK-20, and testing method is: test specimen often compresses the numerical value that 0.5mm records pressure, finally utilizes SigmaPlot (11.0) Software on Drawing to go out curve.
the comparative example 1 of embodiment 1:the preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel
The hydroxyapatite aqueous solution is prepared by the method implementation step (1) in embodiment 1, (3), (4), and linking agent, initiator solution.
The preparation of HA/PAM composite aquogel: add monomeric acrylamide 2g in test tube, then taking 0.5mL cross-linking agent solution drips in test tube, the solution that (1) that takes 1mL again obtains drips in test tube, and add 4mL intermediate water concussion shake up, monomer whose is fully dissolved; Then test tube is sealed, add 0.5mL initiator and 0.02mL accelerator subsequently, initiated polymerization; After reaction carries out 12h at 25 DEG C, HA/ PAM composite aquogel can be prepared.
Then, being cut into diameter is 13mm, and the high cylinder specimen for 20mm carries out compression performance test.The results are shown in Figure 1.
the comparative example 2 of embodiment 1:the preparation method of polyacrylamide
Linking agent, initiator solution is prepared by the method for embodiment 1.
In test tube, add monomeric acrylamide 2g, take 0.5mL cross-linking agent solution and drip in test tube, and add 5mL intermediate water concussion shake up, monomer is fully dissolved; Then sealed by test tube, add 0.5mL initiator and 0.02mL accelerator subsequently, initiated polymerization can prepare PAM polymkeric substance after carrying out 10h at 25 DEG C.Then, compound hydrogel material being cut into diameter is 13mm, and the high cylinder specimen for 15mm carries out compression performance test.The results are shown in Figure 1.
The test result analysis of embodiment 1 and comparative example thereof:
Fig. 1 is the load-displacement curves figure of the hydroxyapatite/graphene oxide/polyacrylamide compound hydrogel material compression of different ratio.As shown in the figure, after adding hydroxyapatite or adding graphene oxide, the compression stiffness of matrix material strengthens, and the matrix material compression stiffness containing hydroxyapatite and polyacrylamide is maximum, visible graphene oxide and hydroxyapatite can the mechanical properties of reinforced composite.
embodiment 2:the preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel
(1) prepare hydroxyapatite (HA) aqueous solution: 0.2g hydroxyapatite (HA) powder of 12 μm is dissolved in 10mL intermediate water, and shake stirring and make it fully dissolve, namely obtain the milky HA solution that concentration is 0.02g/mL;
(2) prepare graphene oxide (GO) aqueous solution: 0.02g graphene oxide (GO) powder is dissolved in 10mL intermediate water, then shake stirring and make it fully dissolve, namely obtaining concentration is the bright GO solution of 0.002g/mL black;
(3) prepare cross-linking agent aqueous solution (MBA): by 0.04g linking agent N, N'-methylene-bisacrylamide (MBA) is dissolved in 10mL intermediate water, and ultrasonic vibration 2min makes Solution Dispersion even, namely obtains the cross-linking agent aqueous solution that concentration is 0.004g/mL;
(4) prepare initiator solution (KPS): get 0.1g initiator potassium persulfate (KPS) and be dissolved in 10mL intermediate water, ultrasonic vibration 2min makes Solution Dispersion even, namely obtains the initiator solution that concentration is 0.01g/mL;
(5) preparation of HA/GO/ PAM composite aquogel: add monomeric acrylamide 2g in test tube, getting 0.5mL cross-linking agent solution is added drop-wise in test tube, get 1mL above-mentioned (1) more respectively, solution that (2) obtain drips in test tube, and add 3mL intermediate water monomer whose is fully dissolved; Then test tube is sealed, add 0.5mL initiator and 0.02mL accelerator, initiated polymerization, react after carrying out 16h at 25 DEG C, namely prepare HA/GO/ PAM composite aquogel.
Described accelerator is N, N, N', N'-Tetramethyl Ethylene Diamine (TEMED), and its density is 0.775g/mL.
Then, being cut into diameter is 13mm, and the compression performance that the cylinder specimen that height is 20mm carries out as above-described embodiment group 1 is tested.The results are shown in Figure 2.
the comparative example 1 of embodiment 2:the preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel
This preparation method is identical with embodiment 2, and difference is: the consumption of graphene oxide (GO) is 2mL, and the consumption of intermediate water is 2mL.
The compression performance test result of the present embodiment is shown in Fig. 2.
the comparative example 2 of embodiment 2:the preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel
This preparation method is identical with embodiment 2, and difference is: the consumption of graphene oxide (GO) is 3mL, and the consumption of intermediate water is 1mL.
The compression performance test result of the present embodiment is shown in Fig. 2.
the comparative example 3 of embodiment 2:the preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel
This preparation method is identical with embodiment 2, and difference is: the consumption of graphene oxide (GO) is 4mL, and the consumption of intermediate water is 0mL.
The compression performance test result of the present embodiment is shown in Fig. 2.
The test result analysis of embodiment 2 and comparative example thereof is as follows:
Fig. 2 is the load-displacement curves figure of the compound hydrogel material compression under different graphene oxide proportioning, illustrates that graphene oxide is a kind of hardened material, along with the rigidity of its compound hydrogel material of increase of its consumption increases.As can be seen from the figure, along with the increase (from 0.002g to 0.008g) of graphene oxide, the compressional stiffness of matrix material strengthens gradually, the increase of visible graphene oxide content can improve the mechanical property of this trielement composite material, therefore graphene oxide can as a kind of composition of the mechanical property of adjustment hydroxyapatite/graphene oxide/Polyacrylamide Composite, the content of graphene oxide can be regulated to make the bone renovating material of different-stiffness, for the selection of different tissues engineer applied in organizational project application like this.
Claims (5)
1. a preparation method for hydroxyapatite/graphene oxide/polyacrylamide composite aquogel, is characterized in that: by hydroxyapatite and graphene oxide wiring solution-forming, be then doped in polyacrylamide network structure, specifically comprise the following steps:
(1) prepare the hydroxyapatite aqueous solution: hydroxyapatite powder is dissolved in intermediate water, and shake stirring and make it fully dissolve, namely obtain milky HA solution;
(2) preparation of graphene oxide solution: graphene oxide powder is dissolved in intermediate water, then shakes stirring and makes it fully dissolve, namely obtain the GO solution that black is bright;
(3) prepare cross-linking agent aqueous solution: get linking agent N, N'-methylene-bisacrylamide is dissolved in the water, and ultrasonic vibration 2min makes Solution Dispersion even, namely obtains cross-linking agent aqueous solution;
(4) prepare initiator solution: get initiator potassium persulfate and be dissolved in the water, ultrasonic vibration 2min makes Solution Dispersion even, namely obtains initiator solution;
(5) preparation of HA/GO/ PAM composite aquogel: add monomeric acrylamide in test tube, getting cross-linking agent solution is added drop-wise in test tube, get above-mentioned (1) more respectively, solution that (2) obtain drips in test tube, and add intermediate water monomer whose is fully dissolved; Then test tube is sealed, add initiator and accelerator, initiated polymerization, react after carrying out 8-16h at 25 DEG C, namely prepare HA/GO/ PAM composite aquogel.
2. the preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel according to claim 1, it is characterized in that: described hydroxyapatite powder grain size is 0.04-12 μm, gained strength of solution is 0.01-0.03g/mL.
3. the preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel according to claim 1, is characterized in that: the concentration of described graphene oxide solution is 0.0005-0.005g/mL.
4. the preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel according to claim 1, it is characterized in that: described initiator is Potassium Persulphate, concentration is 0.005-0.01g/mL; Described linking agent is N, N'-methylene-bisacrylamide, and concentration is 0.001-0.005g/mL.
5. the preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite aquogel according to claim 1, it is characterized in that: described accelerator is N, N, N', N'-Tetramethyl Ethylene Diamine, the consumption of accelerator and the mass ratio of monomeric acrylamide are 7.75:1000; The mass ratio of monomeric acrylamide, initiator, linking agent is (250 ~ 1500): 2.5:1; The mass ratio (0.1-0.5) of described hydroxyapatite, graphene oxide, monomeric acrylamide: (0.0005-0.005): (2-4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410467736.XA CN104231167A (en) | 2014-09-15 | 2014-09-15 | Preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite hydrogel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410467736.XA CN104231167A (en) | 2014-09-15 | 2014-09-15 | Preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite hydrogel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104231167A true CN104231167A (en) | 2014-12-24 |
Family
ID=52220145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410467736.XA Pending CN104231167A (en) | 2014-09-15 | 2014-09-15 | Preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite hydrogel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104231167A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104773802A (en) * | 2015-03-23 | 2015-07-15 | 青岛大学 | High adsorption performance composite flocculant aerogel and preparation method thereof |
| CN106860916A (en) * | 2017-04-06 | 2017-06-20 | 福州大学 | A kind of GO/nHA/ collagen composites bone renovating material and preparation method thereof |
| CN110157132A (en) * | 2019-05-17 | 2019-08-23 | 浙江大学 | A kind of equal phase composite materials of high intensity organic and inorganic and preparation method and application |
| CN110591313A (en) * | 2019-09-19 | 2019-12-20 | 贵州大学 | Levorotatory polylactic acid/hydroxyapatite/graphene oxide ternary composite material |
| CN112876594A (en) * | 2021-01-21 | 2021-06-01 | 中南大学 | Hydrogel material and preparation method thereof |
| CN114085321A (en) * | 2021-11-18 | 2022-02-25 | 四川大学 | Hydrogel microsphere with excellent compression performance and water loss resistance and preparation method thereof |
| CN116177759A (en) * | 2023-04-19 | 2023-05-30 | 交通运输部天津水运工程科学研究所 | Biological film filler for sewage treatment and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103845757A (en) * | 2013-12-13 | 2014-06-11 | 天津大学 | Artificial articular cartilage material and preparation method thereof |
-
2014
- 2014-09-15 CN CN201410467736.XA patent/CN104231167A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103845757A (en) * | 2013-12-13 | 2014-06-11 | 天津大学 | Artificial articular cartilage material and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| A.K. BAJPAI等: "Development of poly(acrylamide)-hydroxyapatite composites as bone substitutes: study of mechanical and blood compatible behavior", 《POLYMER COMPOSITES》 * |
| JIANFENG SHEN等: "Study on graphene-oxide-based polyacrylamide composite hydrogels", 《COMPOSITES: PART A》 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104773802A (en) * | 2015-03-23 | 2015-07-15 | 青岛大学 | High adsorption performance composite flocculant aerogel and preparation method thereof |
| CN106860916A (en) * | 2017-04-06 | 2017-06-20 | 福州大学 | A kind of GO/nHA/ collagen composites bone renovating material and preparation method thereof |
| CN106860916B (en) * | 2017-04-06 | 2020-06-12 | 福州大学 | GO/nHA/collagen composite bone repair material and preparation method thereof |
| CN110157132A (en) * | 2019-05-17 | 2019-08-23 | 浙江大学 | A kind of equal phase composite materials of high intensity organic and inorganic and preparation method and application |
| CN110591313A (en) * | 2019-09-19 | 2019-12-20 | 贵州大学 | Levorotatory polylactic acid/hydroxyapatite/graphene oxide ternary composite material |
| CN110591313B (en) * | 2019-09-19 | 2021-08-31 | 贵州大学 | Levorotatory polylactic acid/hydroxyapatite/graphene oxide ternary composite material |
| CN112876594A (en) * | 2021-01-21 | 2021-06-01 | 中南大学 | Hydrogel material and preparation method thereof |
| CN114085321A (en) * | 2021-11-18 | 2022-02-25 | 四川大学 | Hydrogel microsphere with excellent compression performance and water loss resistance and preparation method thereof |
| CN114085321B (en) * | 2021-11-18 | 2022-12-30 | 四川大学 | Hydrogel microsphere with excellent compression performance and water loss resistance and preparation method thereof |
| CN116177759A (en) * | 2023-04-19 | 2023-05-30 | 交通运输部天津水运工程科学研究所 | Biological film filler for sewage treatment and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104231167A (en) | Preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite hydrogel | |
| CN104258461B (en) | A kind of preparation method of chitosan/oxidized Graphene/hydroxyapatite/Polyacrylamide Composite | |
| CN104189960B (en) | A kind of preparation method of composite aquogel | |
| US11365293B2 (en) | Xylan-based dual network nanocomposite hydrogel, preparation method thereof and use therefor | |
| CN101161689B (en) | Method for preparing rapid-responding and high mechanical performance hydrogel | |
| CN105461945B (en) | A kind of covalent double-network hydrogel of ion and preparation method thereof | |
| CN104177541B (en) | There is the preparation method of carbon point/polyacrylamide cartilage substitution material of fluorescent tracing performance | |
| CN110078866A (en) | A kind of nano-cellulose-polymer composite hydrogel and its preparation method and application | |
| CN100406499C (en) | Nanometer composite hydrogel and preparation method thereof | |
| CN105086001A (en) | Hyaluronic acid-gelatin/acrylamide double-network aquagel and preparation method thereof | |
| CN104262881A (en) | Method for preparing high-strength double-network nano silicon dioxide composite hydrogel | |
| CN101524630B (en) | Preparation of nano composite gel with organic/inorganic hybrid microspheres as crosslinking points | |
| RU2007139503A (en) | POWDER WATER-ABSORBING RESIN AND ABSORBING PRODUCT | |
| CN101270173A (en) | High-gel strength, salt resistant amphoteric ion type nano-composite hydrogel and preparing method | |
| CN104341556A (en) | Preparation method of high-strength double-network nano hectorite composite aquagel | |
| CN106432755A (en) | Preparation method of composite carboxymethyl chitosan/graphene oxide/polyacrylamide hydrogel | |
| CN108714246A (en) | A kind of preparation method for the high intensity hydrogel cartilage substitute that can be combined with subchondral bone | |
| MX2014004884A (en) | Highly swellable polymers. | |
| CN102964528B (en) | Novel high-strength microgel composite hydrogel | |
| CN110157012A (en) | A kind of preparation method of high-intensity and high-tenacity gelatin based aquagel | |
| CN106366248A (en) | Starch-based absorbent resin and preparation method therefor | |
| CN109893681A (en) | A kind of preparation method for repair of cartilage/electronic skin conductive hydrogel | |
| CN110437843B (en) | Preparation method of oil shale semicoke-based composite water-retaining agent | |
| CN1526747A (en) | Environment responding aquogel copolymer and its prepn | |
| CN102977277B (en) | Preparation method of novel high-strength micro-gel composite hydrogel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141224 |