CN104198640B - In food contact material, aldehydes matter migrates to the assay method of oiliness analogies - Google Patents
In food contact material, aldehydes matter migrates to the assay method of oiliness analogies Download PDFInfo
- Publication number
- CN104198640B CN104198640B CN201410457878.8A CN201410457878A CN104198640B CN 104198640 B CN104198640 B CN 104198640B CN 201410457878 A CN201410457878 A CN 201410457878A CN 104198640 B CN104198640 B CN 104198640B
- Authority
- CN
- China
- Prior art keywords
- aldehydes matter
- analogies
- assay method
- liquid
- contact material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
In a kind of food contact material, aldehydes matter migrates to the assay method of oiliness analogies, assay method is as follows: adding mass ratio in reaction vessel is the organic ion liquid of 1:0.75��30 and Oleum Helianthi sample to be extracted, vortex oscillation extracts 1��9min, then ultrasonic extraction 15��20min at 20��70 DEG C, then centrifugal treating 10��20min when 4000��5000rpm again, take off the sub-liquid phase of leafing, utilize high performance liquid chromatography-fluorescence to analyze the content of ionic liquid middle aldehydes matter mutually. Select organic ion liquid as extractant, organic ion liquid is a kind of environmentally friendly organic solvent, there is non-volatile, colourless, odorless feature, use safety and effect of extracting good, extraction results is analyzed by application fluoroscopic examination simultaneously, not only sensitivity well also has higher selectivity, the qualitative of chromatograph and quantitatively on more accurate, improve the accuracy of experimental result.
Description
Technical field
The present invention relates to aldehydes matter detection field, particularly relate to aldehydes matter in a kind of food contact material and migrate to the assay method of oiliness analogies
Background technology
Phenolic compound is the hydroxyl derivant of aromatic hydrocarbons, can be divided into Volatile Phenols and fixedness phenol according to its volatility, is a kind of important industrial chemicals, may be utilized in fabricating dyestuff, medicine, phenolic resin, adhesive etc.Phenolic compound is the chemical toxicant of a kind of moderate strength, can enter internal through mucocutaneous, respiratory tract and digestive tract, low concentration can cause accumulative chronic poisoning, high concentration can cause acute poisoning so that stupor is dead, as skin, mucosa are had strong corrosiveness by phenol, it is possible to suppress central nervous system or infringement Liver and kidney function. It has been reported that phenol liquid pollutes skin area when being 25%, 10 minutes i.e. death, wrongly take and digestive tract can be caused to burn, gastrointestinal perforation occurs, and may occur in which shock, pulmonary edema, liver or renal damage. Some phenolic compounds are also listed in environmental hormone list by EPA, as: bisphenol-A (BPA), animal experiment finds that BPA has oestrogen-like hormone characteristic, the BPA of low dosage can make animal produce the effects such as female sexual precosity, sperm count decline, prostate growth, also there is certain fetal toxicity and teratogenecity simultaneously, can substantially increase the generation of the cancers such as animal ovary cancer, carcinoma of prostate, leukemia.
Food simulants refers to the material of the migration characteristic that simulation real food shows in real-world conditions in contact process with food contact material, can being a kind of solvent or the mixture of several solvent, selecting properly food simulants be the maximum CCP truly assessing food contact material migration problem. Some aldehydes matters in food contact material are moved in food simulants all finite quantity regulations by country variant and area, as the bulletin of MHLW 370 of Japan specifies that in PC material, phenol, bisphenol-A, the p-t-butyl phenol limitation in food simulants is 2.5mg/L; European Union is to the limitation of the p-t-butyl phenol in food simulants specifies it is 0.05mg/L.
Owing to phenolic compound migrates to food simulants in food contact material, concentration is relatively low and matrix composition is complicated, thus in measuring food simulants, during phenolic compound, need to use the extraction of separation and concentration technology such as liquid-liquid extraction, solid phase (micro-) and liquid-liquid-liquid microextraction etc., and above-mentioned several abstraction technique is required for using a certain amount of volatile, organic solvent that toxicity is big, to experimenter and environmentally undesirable. The quantitative approach measuring phenolic compound conventional at present is gas chromatography (GC) and high performance liquid chromatography (HPLC).
Summary of the invention
The technical problem to be solved is to provide aldehydes matter in the food contact material that a kind of Detection results is good and safe to migrate to the assay method of oiliness analogies for prior art.
This invention address that the technical scheme that above-mentioned technical problem adopts is: adding mass ratio in reaction vessel is the organic ion liquid of 1:0.75��30 and Oleum Helianthi sample to be extracted, vortex oscillation extracts 1��9min, then ultrasonic extraction 15��20min at 20��70 DEG C, then centrifugal treating 10��20min when 4000��5000rpm again, take off the sub-liquid phase of leafing, utilize high performance liquid chromatography-fluorescence to analyze the content of ionic liquid middle aldehydes matter mutually.
Above-mentioned Oleum Helianthi sample is the food simulants obtained by migration test by food contact material or the aldehydes matter solution configured by Oleum Helianthi, the mode of migration test has multiple, for instance: phenolic resin-made handle is soaked under 120 DEG C of conditions in Oleum Helianthi the food simulants of 30min.
Phenol, bisphenol-A and p-t-butyl phenol are common aldehydes matter, and therefore the described aldehydes matter in such scheme is the one in phenol, bisphenol-A or p-t-butyl phenol.
Described organic ion liquid is hexafluorophosphate, tetrafluoroborate, chlorination 1-octyl group-3-Methylimidazole., N-EPB, N-butyl pyridinium chloride or the one in chlorination 1-butyl-3-Methylimidazole..
As preferably, described organic ion liquid is tetrafluoroborate.
The preferred mass of described organic ion liquid and Oleum Helianthi sample to be extracted ratio is for 1:30, and the preferred extraction time that described vortex oscillation extracts is 3min, and the preferred extraction temperature of described ultrasonic extraction is 20 DEG C.
The testing conditions of above-mentioned high performance liquid chromatography-fluorescence is:
Liquid-phase condition: leacheate is VAcetonitrile:VWaterThe mixed solution of=30:70, after 17min, linear gradient is changed to VAcetonitrile:VWaterWhen=64:36,19min, acetonitrile changes to 100%, and during 20min, acetonitrile linear change is to 30%, sample size 10 �� L, flow velocity 1mL min-1, post case temperature 40 DEG C;
Chromatographic condition: chromatographic column adopts DiamonsilC18Post, this chromatographic column specification is 150 �� 4.6mm, particle diameter 5 ��m, fluoroscopic examination wavelength: transmitting wavelength is 310nm, and excitation wavelength is 270nm.
Compared with prior art, it is an advantage of the current invention that:
(1) present invention selects organic ion liquid as extractant in Oleum Helianthi sample extraction, compared with volatile, the organic solvent that toxicity is big used in prior art, organic ion liquid is a kind of environmentally friendly organic solvent, there is non-volatile, colourless, odorless feature, use safety and effect of extracting good.
(2) extraction results is analyzed by application fluoroscopic examination, compared with traditional gas chromatography (GC) and high performance liquid chromatography (HPLC), not only sensitivity well also has higher selectivity, the qualitative of chromatograph and quantitatively on more accurate, improve the accuracy of experimental result.
To sum up, the present invention utilizes organic ion liquid as extractant, have studied the kind of organic ion liquid, the treating capacity of aldehydes matter, vortex extraction time and the impact on effect of extracting of the ultrasonic extraction temperature, the detection migrating to oiliness analogies for studying aldehydes matter in food contact material further provides basis.
Accompanying drawing explanation
Fig. 1 is the effect of extracting comparison diagram of different organic ion liquid in the embodiment of the present invention 1;
Fig. 2 is the effect of extracting comparison diagram of different organic ion volumes in the embodiment of the present invention 1;
Fig. 3 is the effect of extracting figure of different vortex extraction times in the embodiment of the present invention 1;
Fig. 4 is the reference colour spectrogram in the embodiment of the present invention 2 under optimum extraction condition;
Fig. 5 is the canonical plotting in the embodiment of the present invention 2 under optimum extraction condition.
Detailed description of the invention
Below in conjunction with accompanying drawing embodiment, the present invention is described in further detail.
Embodiment 1:
1, assay method
Sample treatment: add organic ion liquid and the Oleum Helianthi sample of certain mass ratio in plastic centrifuge tube, vortex oscillation extracts, then ultrasonic extraction is carried out at a certain temperature, then centrifugal treating 10��20min when 4000��5000rpm again, take off the sub-liquid phase of leafing, in the present embodiment, Oleum Helianthi sample is the aldehydes matter solution configured by sunflower oil, and the aldehydes matter in the present embodiment is any one in phenol, bisphenol-A or p-t-butyl phenol.
Testing conditions: utilizing high performance liquid chromatography-fluorescence to analyze the content of aldehydes matter in ionic liquid, instrument is Waters2695e, 2475 fluorescence detectors. Liquid-phase condition: leacheate is VAcetonitrile:VWaterThe mixed solution of=30:70, after 17min, linear gradient is changed to VAcetonitrile:VWaterWhen=64:36,19min, acetonitrile changes to 100%, and during 20min, acetonitrile linear change is to 30%, sample size 10 �� L, flow velocity 1mL min-1, post case temperature 40 DEG C;Chromatographic condition: chromatographic column adopts DiamonsilC18Post, this chromatographic column specification is 150 �� 4.6mm, particle diameter 5 ��m, fluoroscopic examination wavelength: transmitting wavelength is 310nm, and excitation wavelength is 270nm.
2, optimization
2.1, the kind of the organic ion liquid impact on effect of extracting
According to above-mentioned assay method and when same measured, respectively hexafluorophosphate, tetrafluoroborate, chlorination 1-octyl group-3-Methylimidazole., N-EPB, N-butyl pyridinium chloride, chlorination 1-butyl-3-Methylimidazole. are used for the aldehydes matter in Oleum Helianthi sample and extract. Test display chlorination 1-octyl group-3-Methylimidazole., N-EPB, N-butyl pyridinium chloride, chlorination 1-butyl-3-Methylimidazole. effect of extracting are poor, and the effect of extracting of hexafluorophosphate and tetrafluoroborate is better. Compare six kinds of ionic liquids of hexafluorophosphate, tetrafluoroborate class further, i.e. 1-butyl-3-methyl hexafluorophosphate ([C4mim][PF6]), 1-hexyl-3-methyl hexafluorophosphate ([C6mim][PF6]), 1-octyl group-3-methyl hexafluorophosphate ([C8mim][PF6]), 1-butyl-3-methyl tetrafluoroborate ([C4mim][BF4]), 1-hexyl-3-methyl tetrafluoroborate ([C6mim][BF4]), 1-octyl group-3-methyl tetrafluoroborate ([C8mim][BF4]) to the extraction results of aldehydes matter in Oleum Helianthi sample, as shown in Figure 1, [C6mim][BF4] effect of extracting is best.
2.2, the treating capacity of the aldehydes matter impact on effect of extracting
According to above-mentioned assay method and when same measured, take [the C of 0.5mL, 1.0mL, 2.0mL, 2.5mL, 5.0mL, 7.5mL, 10mL, 15mL, 20mL respectively6mim][BF4] as extractant, respectively to the phenol containing certain mass, bisphenol-A, p-t-butyl phenol Oleum Helianthi sample carry out extraction test, make Solvent quantity and be extracted Oleum Helianthi sample quality than respectively 1:0.75,1:1,1:1.5,1:2,1:3,1:6,1:7.5,1:15,1:30. Result is as shown in Figure 2, ionic liquid is different to the extracting power of different phenol, for p-t-butyl phenol, when sample quality is 10g, its extraction has been reached saturated by ionic liquid, phenol is then have the trend reaching balance when sample size reaches 15g, and ionic liquid is then stronger to the extracting power of bisphenol-A, also shows stronger extracting power when sample size reaches 20g.
Due to [C6mim][BF4] extraction of p-t-butyl phenol is substantially reached balance when 7.5g, and when sample size is 10g, the detection limit of sample can meet the limitation requirement of European Union bisphenol-A limitation 0.6mg/kg and p-t-butyl phenol 0.05mg/kg, and in practical operation, vortex is produced relatively difficult when sample size is 20g, therefore the present embodiment selects the sample quality extracted to be 15g, and namely ionic liquid consumption and sample quality ratio is for 1:30.
2.3, the vortex time impact on effect of extracting
According to above-mentioned assay method and when same measured, investigating vortex extraction time respectively is effect of extracting when 0min, 1min, 2min, 3min, 5min, 7min, 9min, result is as shown in Figure 3, extract namely up to balance after vortex oscillation 1min, it is contemplated that time slightly longer extraction efficiency is more easy to and reaches unanimity, so the present embodiment selects vortex time to be 3min.
2.4, the ultrasonic temperature impact on effect of extracting
According to above-mentioned assay method and when same measured, during research ultrasonic extraction, extraction temperature is effect of extracting when 20 DEG C, 30 DEG C, 40 DEG C, 50 DEG C, 60 DEG C, 70 DEG C respectively, found that temperature is on extracting almost without impact, but extraction temperature height easily causes ionic liquid dissolubility in Oleum Helianthi to improve, more than 40 DEG C just have been observed that the material having one layer of emulsion layer class between ionic liquid and Oleum Helianthi, being unfavorable for the separation and Extraction of ionic liquid, therefore the temperature of selected ultrasonic extraction is 20 DEG C.
Can being obtained from above, optimum extraction condition is: organic ion liquid selects the mass ratio of tetrafluoroborate, organic ion volume and aldehydes matter to be extracted to be 1:30, and vortex oscillation extraction time is 3min, and ultrasonic extraction temperature is 20 DEG C.
2.5, optimum extraction condition compares with existing extracting process
Migration test: phenolic resin-made handle soaks 30min in Oleum Helianthi and obtains sunflower oil analogies under 120 DEG C of conditions.
At present for the bisphenol-A in oiliness analogies, the method for EN13130-13-2005 is with methanol: water (1:1) extracts. Three kinds of aldehydes matters are extracted by method described in application EN13130-13-2005, and compare with the scheme of the present embodiment, it has been found that organic ion liquid extraction phenol that the present embodiment adopts, bisphenol-A, p-t-butyl phenol bioaccumulation efficiency be the 10 of EN method, 10 and 18 times respectively.
Extracting by method Pyrogentisinic Acid's positive of EN, extract fluoroscopic examination also compares with the method for the present embodiment, and result is as shown in table 1, it is seen that the effect of extracting of the optimum extraction condition of the present embodiment is more preferably.
Table 1
Embodiment 2: the mensuration of linear equation, detection limit and reference colour spectrogram
The configuration of phenols standard sample: weigh 7 parts of ionic liquid 0.5745g respectively and be separately added in 7 test tubes, then in 7 test tubes, add 0.0200g respectively, 0.15g, 0.6g, 1.2g, 5.0g, 15.0g the aldehydes matter mark liquid that concentration is 10mg/kg and the aldehydes matter mark liquid that 15.00g concentration is 20mg/kg, and in each pipe, add Oleum Helianthi respectively, making the sample size in every pipe is 15.00g, the now concentration respectively 0.0133mg/kg of aldehydes matter in each pipe, 0.10mg/kg, 0.40mg/kg, 0.8mg/kg, 3.33mg/kg, 10.0mg/kg, 20.0mg/kg.
Adopt the optimum extraction condition obtained in embodiment 1 that above-mentioned phenols standard sample is extracted, after extraction, carry out upper machine analysis. The range of linearity of phenol, bisphenol-A and p-t-butyl phenol, repeatability (relative standard deviation) and detection limit (S/N=3) are as shown in table 2, in the concentration range measured, the peak area value (y) that the concentration (x) of phenol, bisphenol-A and p-t-butyl phenol is corresponding presents good linear relationship, the RSD (relative standard deviation) < 2% of 3 kinds of materials, has good repeatability; Fig. 4 is reference colour spectrogram, and Fig. 5 is canonical plotting, and relative standard deviation is through pre-treatment by the aldehydes matter mark-on sample that concentration is 1mg/kg, and upper machine calculates and obtains.
Table 2
Embodiment 3: determination of recovery rates
Under above-mentioned optimum extraction condition, utilize additive process to measure the response rate of this assay method. Adopt additive process, above-mentioned gained sunflower oil analogies are added phenol, bisphenol-A and p-t-butyl phenol respectively, interpolation concentration respectively 1.0mg/kg, 2.0mg/kg and 4.0mg/kg of every kind of aldehydes matter, each interpolation concentration level measures 6 times, carrying out response rate calculating, recovery test result is as shown in table 3. From table 3, the response rate of this assay method is good, and this assay method is to the response rate of phenol, bisphenol-A and p-t-butyl phenol in sunflower oil analogies respectively 93.8 �� 1.7%��103.9 �� 1.4%, 88.0 �� 1.9%��97.0 �� 1.7%, 97.0 �� 3.5%��104.0 �� 2.5%.
Table 3
Claims (5)
1. in a food contact material, aldehydes matter migrates to the assay method of oiliness analogies, it is characterized in that: adding mass ratio in reaction vessel is the organic ion liquid of 1:0.75��30 and Oleum Helianthi sample to be extracted, vortex oscillation extracts 1��9min, then ultrasonic extraction 15��20min at 20��70 DEG C, then centrifugal treating 10��20min when 4000��5000rpm again, take off the sub-liquid phase of leafing, high performance liquid chromatography-fluorescence is utilized to analyze the content of ionic liquid middle aldehydes matter mutually, described aldehydes matter is phenol, one in bisphenol-A or p-t-butyl phenol, described organic ion liquid is the one in hexafluorophosphate or tetrafluoroborate.
2. in food contact material as claimed in claim 1, aldehydes matter migrates to the assay method of oiliness analogies, it is characterised in that: described Oleum Helianthi sample is the Oleum Helianthi analogies obtained by migration test by food contact material or the aldehydes matter solution configured by Oleum Helianthi.
3. in food contact material as claimed in claim 1, aldehydes matter migrates to the assay method of oiliness analogies, it is characterised in that: described organic ion liquid is tetrafluoroborate.
4. in food contact material as claimed in claim 1, aldehydes matter migrates to the assay method of oiliness analogies, it is characterized in that: the mass ratio of described organic ion liquid and Oleum Helianthi sample to be extracted is 1:30, described vortex oscillation extraction time is 3min, and described ultrasonic extraction temperature is 20 DEG C.
5. in food contact material as claimed in claim 1, aldehydes matter migrates to the assay method of oiliness analogies, it is characterised in that: in described high performance liquid chromatography-fluorescence,
Liquid-phase condition: leacheate is VAcetonitrile:VWaterThe mixed solution of=30:70, after 17min, linear gradient is changed to VAcetonitrile:VWaterWhen=64:36,19min, acetonitrile changes to 100%, and during 20min, acetonitrile linear change is to 30%, sample size 10 �� L, flow velocity 1mL min-1, post case temperature 40 DEG C;
Chromatographic condition: chromatographic column adopts DiamonsilC18Post, this chromatographic column specification is 150 �� 4.6mm, particle diameter 5 ��m, fluoroscopic examination wavelength: transmitting wavelength is 310nm, and excitation wavelength is 270nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410457878.8A CN104198640B (en) | 2014-09-10 | 2014-09-10 | In food contact material, aldehydes matter migrates to the assay method of oiliness analogies |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410457878.8A CN104198640B (en) | 2014-09-10 | 2014-09-10 | In food contact material, aldehydes matter migrates to the assay method of oiliness analogies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104198640A CN104198640A (en) | 2014-12-10 |
| CN104198640B true CN104198640B (en) | 2016-06-08 |
Family
ID=52083964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410457878.8A Active CN104198640B (en) | 2014-09-10 | 2014-09-10 | In food contact material, aldehydes matter migrates to the assay method of oiliness analogies |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104198640B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105021754A (en) * | 2015-07-03 | 2015-11-04 | 中华人民共和国台州出入境检验检疫局 | Liquid chromatography-tandem mass spectrometry method for simultaneous determination of specific migration of 18 phenols or phenol derivatives in five plastic food simulants |
| CN105021753B (en) * | 2015-07-03 | 2016-07-13 | 中华人民共和国台州出入境检验检疫局 | Liquid chromatograph ultraviolet method measures 9 kinds of ultraviolet absorber specific transfer metering methods |
| CN105021725B (en) * | 2015-07-03 | 2017-01-25 | 中华人民共和国台州出入境检验检疫局 | Liquid chromatography-tandem mass spectrometry method for detection of specific total migration of nine ultraviolet absorbers |
| CN109975466A (en) * | 2017-12-28 | 2019-07-05 | 厦门市产品质量监督检验院 | The detection method of bisphenol-A in a kind of shopping receipt |
| CN110887903A (en) * | 2018-09-11 | 2020-03-17 | 山东省医疗器械产品质量检验中心 | Method for measuring bisphenol A residue in hemodialyzer |
| CN109470804B (en) * | 2018-12-11 | 2021-08-31 | 温州医科大学 | Application of double-positive imidazolium salt ionic liquid in extraction of bisphenol compounds and micro-extraction technology based on ionic liquid |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060076269A (en) * | 2003-07-21 | 2006-07-04 | 바스프 악티엔게젤샤프트 | Method for extracting impurities using ionic liquids |
| CN102692474A (en) * | 2012-06-06 | 2012-09-26 | 昆明理工大学 | Method for rapidly detecting bisphenol A and bisphenol AF in food |
| CN104007218A (en) * | 2014-06-06 | 2014-08-27 | 北京礼来科技发展中心 | Determination method of bisphenol S transfer volume in plastic food packaging materials |
-
2014
- 2014-09-10 CN CN201410457878.8A patent/CN104198640B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060076269A (en) * | 2003-07-21 | 2006-07-04 | 바스프 악티엔게젤샤프트 | Method for extracting impurities using ionic liquids |
| US20070193952A1 (en) * | 2003-07-21 | 2007-08-23 | Basf Aktiengesellschaft | Method For Extracting Impurities Using Ionic Liquids |
| CN102692474A (en) * | 2012-06-06 | 2012-09-26 | 昆明理工大学 | Method for rapidly detecting bisphenol A and bisphenol AF in food |
| CN104007218A (en) * | 2014-06-06 | 2014-08-27 | 北京礼来科技发展中心 | Determination method of bisphenol S transfer volume in plastic food packaging materials |
Non-Patent Citations (6)
| Title |
|---|
| Determination of bisphenol A, 4-n-nonylphenol, and 4-tert-octylphenol by temperature-controlled ionic liquid dispersive liquid-phase microextraction combined with high performance liquid chromatography-fluorescence detector;Qingxiang Zhou et al.;《Talanta》;20110625;第85卷;page 1598–1602 * |
| Separation of Phenols from Oil Using Imidazolium-Based Ionic Liquids;Yucui Hou et al.;《Industrial & Engineering Chemistry Research》;20131125;第52卷;Page 18071−18075 * |
| 离子液体用于油中酚类化合物萃取分离的研究;彭威;《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》;20121215(第12期);第19页2.2.3节，第32-33页"2.3.1.3 温度对萃取效果的影响"节， * |
| 离子液体萃取-高效液相色谱法测定食品接触材料中6种芳香胺的迁移量;朱晓艳 等;《理化检验-化学分册》;20131231;第49卷(第10期);1188-1192页 * |
| 离子液体-高效液相色谱法测定食品接触材料中3种酚类物质的迁移量;朱晓艳 等;《食品科技》;20131231;第38卷(第9期);第291页"摘要"，第292页左栏1-3段，"1 材料与方法"节，2.1节，第293-294页2.3-2.5节，图4 * |
| 高效液相色谱法测定食品接触材料中苯酚和4-叔丁基苯酚迁移量;李英 等;《分析试验室》;20110930;第30卷(第9期);120-123页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104198640A (en) | 2014-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104198640B (en) | In food contact material, aldehydes matter migrates to the assay method of oiliness analogies | |
| Farajzadeh et al. | Derivatization and microextraction methods for determination of organic compounds by gas chromatography | |
| Liu et al. | A highly efficient vortex-assisted liquid–liquid microextraction based on natural deep eutectic solvent for the determination of Sudan I in food samples | |
| Maya et al. | Completely automated in-syringe dispersive liquid–liquid microextraction using solvents lighter than water | |
| Farajzadeh et al. | Simultaneous synthesis of a deep eutectic solvent and its application in liquid–liquid microextraction of polycyclic aromatic hydrocarbons from aqueous samples | |
| Tolcha et al. | Low‐density extraction solvent based solvent‐terminated dispersive liquid–liquid microextraction for quantitative determination of ionizable pesticides in environmental waters | |
| Xiao et al. | Application of derivative and derivative ratio spectrophotometry to simultaneous trace determination of rhodamine B and rhodamine 6G after dispersive liquid–liquid microextraction | |
| CN104749298A (en) | Solid phase extraction column for separating different hydrocarbon components in diesel oil and application method | |
| Peng et al. | Vortex‐assisted liquid–liquid microextraction using a low‐toxicity solvent for the determination of five organophosphorus pesticides in water samples by high‐performance liquid chromatography | |
| Wei et al. | Rapid and sensitive determination of multiple endocrine‐disrupting chemicals by ultrasound‐assisted in situ derivatization dispersive liquid–liquid microextraction coupled with ultra‐high‐performance liquid chromatography/tandem mass spectrometry | |
| Jowkarderis et al. | Optimization of supercritical fluid extraction combined with dispersive liquid–liquid microextraction as an efficient sample preparation method for determination of 4-nitrotoluene and 3-nitrotoluene in a complex matrix | |
| CN101893612A (en) | Method for determining content of astaxanthin in antarctic krill oil by chromatography | |
| Guo et al. | Citrinin selective molecularly imprinted polymers for SPE | |
| CN103472170A (en) | Method for detecting benzopyrene in edible oil | |
| Cristina Henriques Alves et al. | Dispersive liquid–liquid microextraction of organophosphorous pesticides using nonhalogenated solvents | |
| Bazregar et al. | Filter‐based emulsification microextraction as an efficient method for the determination of chlorophenols by gas chromatography | |
| Hosseini et al. | Use of ionic liquids for trace analysis of methyl tert-butyl ether in water samples using in situ solvent formation microextraction technique and determination by GC/FID | |
| Hassan et al. | Miniaturized counter current liquid–liquid extraction for organophosphorus pesticides determination | |
| Sedaghat et al. | Extraction and preconcentration of hemin from human blood serum and breast cancer supernatant | |
| Hung et al. | Separation of cannabinoids on three different mixed‐mode columns containing carbon/nanodiamond/amine‐polymer superficially porous particles | |
| CN104101661B (en) | A kind of method for quick of Detection of Magdala in Food Through | |
| Medina et al. | Development of a dispersive liquid–liquid microextraction method using a lighter‐than‐water ionic liquid for the analysis of polycyclic aromatic hydrocarbons in water | |
| Zhang et al. | Ionic liquid foam floatation coupled with ionic liquid dispersive liquid–liquid microextraction for the separation and determination of estrogens in water samples by high‐performance liquid chromatography with fluorescence detection | |
| Zhang et al. | Comparison of two ionic liquid-based pretreatment methods for three steroids' separation and determination in water samples by HPLC | |
| Mokhtari et al. | Preconcentration and determination of methyl methacrylate by dispersive liquid–liquid microextraction |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: 315000 Block A, Qingyi Road, Ningbo High-tech Zone, Zhejiang Province Patentee after: Ningbo Institute of Inspection and Quarantine Science Technology Address before: 315012 Ma Yuan Road, Haishu District, Ningbo, Zhejiang Province, No. 9 Patentee before: Ningbo Institute of Inspection and Quarantine Science Technology |