CN104188932A - Cefcapene pivoxil hydrochloride composition - Google Patents
Cefcapene pivoxil hydrochloride composition Download PDFInfo
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- CN104188932A CN104188932A CN201410481475.7A CN201410481475A CN104188932A CN 104188932 A CN104188932 A CN 104188932A CN 201410481475 A CN201410481475 A CN 201410481475A CN 104188932 A CN104188932 A CN 104188932A
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- pivoxil hydrochloride
- cefcapene pivoxil
- cefcapene
- starch
- hydrochloride composition
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
The invention discloses a cefcapene pivoxil hydrochloride composition which is obtained by tabletting cefcapene pivoxil hydrochloride, starch, hydroxy propyl cellulose, carboxymethyl starch sodium, magnesium stearate and medical film coating premixed excipients. The cefcapene pivoxil hydrochloride composition has the benefits that the dissolution of the cefcapene pivoxil hydrochloride composition reaches above 90 percent, the use effect of the cefcapene pivoxil hydrochloride composition is improved, and the utilization rate of drugs can be effectively improved.
Description
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Technical field
The present invention relates to field of medicaments, particularly, relate to a kind of Method of cefcapene pivoxil hydrochloride compositions.
Background technology
Method of cefcapene pivoxil hydrochloride is used for the treatment of by dense around the secondary infection of the wounds such as the microbial epidermis infection of sensitivity, skin deep part infection, chronic Pyoderma, wound, scald and operation wound, mastitis, anus, pharyngitis, laryngitis, dental tissue infection, periodontitis etc.At present Method of cefcapene pivoxil hydrochloride generally adopts tablet because of convenient oral.But Method of cefcapene pivoxil hydrochloride is slightly soluble in ethanol, water-soluble hardly, the dissolution that how to improve its dissolubility, increase tablet always is the problem of paying close attention on pharmacy preparation.
The patent that the name that application number is 201110035286.3 is called Method of cefcapene pivoxil hydrochloride composition and method of making the same provides a kind of Method of cefcapene pivoxil hydrochloride composition and method of making the same, said composition adds that by Method of cefcapene pivoxil hydrochloride, starch, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium micropowder silica gel and lubricant form, and its dissolution is the highest just reaches 79%.Dissolution is too low, and drug effect takes effect slowly, and drug effect is low, is unfavorable for clinical application.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Method of cefcapene pivoxil hydrochloride compositions, this tablet is got by Method of cefcapene pivoxil hydrochloride, starch, hydroxypropyl cellulose, carboxymethyl starch sodium, magnesium stearate, medicinal film-coating premixing auxiliary material tabletting, the dissolution of this tablet can reach more than 90%, improve the result of use of Method of cefcapene pivoxil hydrochloride sheet, can effectively expand the utilization rate of medicine.
The present invention addresses the above problem adopted technical scheme:
A kind of Method of cefcapene pivoxil hydrochloride compositions, comprises following composition by weight:
Method of cefcapene pivoxil hydrochloride 120-150
Starch 40-55
Hydroxypropyl cellulose 18-25
Carboxymethyl starch sodium 8-18
Magnesium stearate 0.8-1.5
Medicinal film-coating premixing auxiliary material 3-9.
A kind of Method of cefcapene pivoxil hydrochloride compositions, comprises following composition by weight:
Method of cefcapene pivoxil hydrochloride 140
Starch 50
Hydroxypropyl cellulose 25
Carboxymethyl starch sodium 15
Magnesium stearate 1.10
Medicinal film-coating premixing auxiliary material 5.
Method of cefcapene pivoxil hydrochloride compositions is generally made up of Method of cefcapene pivoxil hydrochloride, filler, disintegrating agent, binding agent, lubricant, the selection of different filler, disintegrating agent, binding agent, lubricant and different proportionings, the tablet properties making by same procedure all can be different, the present invention selects starch, hydroxypropyl cellulose, magnesium stearate, carboxymethyl starch sodium through great many of experiments, again by Dissolution of Tablet that the many experiments of consumption is finally obtained more than 90%, obtained the progress of salience.
To sum up, the invention has the beneficial effects as follows:
The method that the present invention adopts branch's mix homogeneously by Method of cefcapene pivoxil hydrochloride, filler, disintegrating agent make can clinical practice medicament, and adopt stomach dissolution type preparation, select suitable reagent mixing ratio by innovative experiment many times, finally obtain higher dissolubility (more than 90%), be conducive to take effect speed and the therapeutic effect of drug effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is done to detailed description further, but embodiments of the present invention are not limited to this.
Embodiment 1
A kind of Method of cefcapene pivoxil hydrochloride compositions, comprises following composition by weight:
Method of cefcapene pivoxil hydrochloride 120
Starch 45
Hydroxypropyl cellulose 22
Carboxymethyl starch sodium 8
Magnesium stearate 0.8
Medicinal film-coating premixing auxiliary material 3.
Embodiment 2:
A kind of Method of cefcapene pivoxil hydrochloride compositions, comprises following composition by weight:
Method of cefcapene pivoxil hydrochloride 150
Starch 40
Hydroxypropyl cellulose 18
Carboxymethyl starch sodium 12
Magnesium stearate 1.5
Medicinal film-coating premixing auxiliary material 9.
Embodiment 3
A kind of Method of cefcapene pivoxil hydrochloride compositions, comprises following composition by weight:
Method of cefcapene pivoxil hydrochloride 126
Starch 42
Hydroxypropyl cellulose 20
Carboxymethyl starch sodium 18
Magnesium stearate 1.0
Medicinal film-coating premixing auxiliary material 4.
Embodiment 4
A kind of Method of cefcapene pivoxil hydrochloride compositions, comprises following composition by weight:
Method of cefcapene pivoxil hydrochloride 132
Starch 45
Hydroxypropyl cellulose 24
Carboxymethyl starch sodium 10
Magnesium stearate 1.2
Medicinal film-coating premixing auxiliary material 6.
Embodiment 5
A kind of Method of cefcapene pivoxil hydrochloride compositions, comprises following composition by weight:
Method of cefcapene pivoxil hydrochloride 138
Starch 48
Hydroxypropyl cellulose 18
Carboxymethyl starch sodium 12
Magnesium stearate 1.5
Medicinal film-coating premixing auxiliary material 8.
Embodiment 6
A kind of Method of cefcapene pivoxil hydrochloride compositions, comprises following composition by weight:
Method of cefcapene pivoxil hydrochloride 140
Starch 50
Hydroxypropyl cellulose 25
Carboxymethyl starch sodium 15
Magnesium stearate 1.10
Medicinal film-coating premixing auxiliary material 5.
Preparation method
The combination formula of above-described embodiment 1-embodiment 6 is prepared by the following method and obtains finished product.
(1) mixed powder: by starch, hydroxypropyl cellulose, drop in three-dimensional mixer and be mixed to get powder A; Again part Method of cefcapene pivoxil hydrochloride is dropped in three-dimensional mixer and is mixed to get powder B with mixed powder A; In being dropped into three-dimensional mixer, remaining Method of cefcapene pivoxil hydrochloride is mixed to get powder C with mixed powder B; Get again in part of stearic acid magnesium input three-dimensional mixer and be mixed to get intermediate I with mixed powder C; By intermediate I granulation, in granule, add carboxymethyl starch sodium to drop in three-dimensional mixer and mix together again, obtain intermediate II after finally adding remaining magnesium stearate to mix;
(2) tabletting: with tablet machine, intermediate II is carried out to tabletting and obtain label;
(3) film coating: label is put into report coating pan and heat, it is 72-80 DEG C that inlet temperature is set, and coating pan rotating speed is 4-6 rev/min, and temperature of outgoing air is controlled at 28-30 DEG C, and sheet bed tempertaure starts coating and finally makes tablet finished product while reaching 32-36 DEG C.
Be 20-30min by the mixed powder time of starch, hydroxypropyl cellulose; Part Method of cefcapene pivoxil hydrochloride drops in three-dimensional mixer and mixed powder A incorporation time is 10-15min; Remaining Method of cefcapene pivoxil hydrochloride drops in three-dimensional mixer and mixed powder B incorporation time is 10-18min.Part of stearic acid magnesium drops in three-dimensional mixer and mixed powder C incorporation time is 12-18min.Control moisture≤3.7% in intermediate I, control moisture≤3.7% in intermediate II.In preparation method, mixed powder pelletization, adopt the mode of branch's mix homogeneously, as first starch, hydroxypropyl cellulose mixed to the mixing homogeneity that a period of time ensures starch, hydroxypropyl cellulose, again part Method of cefcapene pivoxil hydrochloride is dropped in three-dimensional mixer and starch, mix homogeneously of hydroxypropyl cellulose, this process is Method of cefcapene pivoxil hydrochloride, filler, disintegrating agent three to be reached to balance in phase.
Finished product dissolubility and the existing dissolubility of the embodiment 1-embodiment 6 obtaining are compared as follows table:
Can find out from the above results, by suitable formulation selection of the present invention, and preparation method does not have a design, dissolubility of the present invention has been brought up to more than 90%, the present invention has outstanding feature and significant progressive, as mentioned above, can realize preferably the present invention.
Claims (2)
1. a Method of cefcapene pivoxil hydrochloride compositions, is characterized in that, comprises following composition by weight:
Method of cefcapene pivoxil hydrochloride 120-150
Starch 40-55
Hydroxypropyl cellulose 18-25
Carboxymethyl starch sodium 8-18
Magnesium stearate 0.8-1.5
Medicinal film-coating premixing auxiliary material 3-9.
2. a kind of Method of cefcapene pivoxil hydrochloride compositions according to claim 1, is characterized in that, comprises following composition by weight:
Method of cefcapene pivoxil hydrochloride 140
Starch 50
Hydroxypropyl cellulose 25
Carboxymethyl starch sodium 15
Magnesium stearate 1.10
Medicinal film-coating premixing auxiliary material 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410481475.7A CN104188932A (en) | 2014-09-21 | 2014-09-21 | Cefcapene pivoxil hydrochloride composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410481475.7A CN104188932A (en) | 2014-09-21 | 2014-09-21 | Cefcapene pivoxil hydrochloride composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104188932A true CN104188932A (en) | 2014-12-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410481475.7A Pending CN104188932A (en) | 2014-09-21 | 2014-09-21 | Cefcapene pivoxil hydrochloride composition |
Country Status (1)
| Country | Link |
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| CN (1) | CN104188932A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102138922A (en) * | 2011-02-01 | 2011-08-03 | 石药集团中奇制药技术（石家庄）有限公司 | Cefcapene pivoxil hydrochloride composition and preparation method thereof |
| US20120156261A1 (en) * | 2009-08-11 | 2012-06-21 | Keiichi Fujiwara | Disintegrating particle composition and orally rapidly disintegrating tablet |
-
2014
- 2014-09-21 CN CN201410481475.7A patent/CN104188932A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120156261A1 (en) * | 2009-08-11 | 2012-06-21 | Keiichi Fujiwara | Disintegrating particle composition and orally rapidly disintegrating tablet |
| CN102138922A (en) * | 2011-02-01 | 2011-08-03 | 石药集团中奇制药技术（石家庄）有限公司 | Cefcapene pivoxil hydrochloride composition and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 雷秀珍: "《盐酸头孢卡品酯片的研制及质量研究》", 《海峡药学》 * |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141210 |