CN104162233A - Near-infrared light therapeutic apparatus for treating brain diseases - Google Patents
Near-infrared light therapeutic apparatus for treating brain diseases Download PDFInfo
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- CN104162233A CN104162233A CN201410450333.4A CN201410450333A CN104162233A CN 104162233 A CN104162233 A CN 104162233A CN 201410450333 A CN201410450333 A CN 201410450333A CN 104162233 A CN104162233 A CN 104162233A
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Abstract
The invention provides a near-infrared light therapeutic apparatus which comprises a light source capable of emitting near-infrared light, a carrier of the light source, a semispherical face support for fixing the carrier, a driver for driving the light source to emit light, a signal controller for providing a control light source for the driver, a man-machine interaction module for information input and output of a whole system and a power source module. The man-machine interaction module is connected with the input end of the controller. The output end of the controller is connected with the input end of the driver, and the output end of the driver is connected with the light source. The power source module is connected with the driver, the controller and the man-machine interaction module. The irradiation range of the light source covers the whole forehead, is downwards flush with the brow ridge, surrounds the temples, the head top and the back side of the head, and is downwards flush with the upper edge of the neck. The wavelength of the light source ranges from 600 nm to 900 nm. According to the near-infrared light therapeutic apparatus, the near-infrared light is originally introduced into treatment of head functional diseases, and the brain functional disease treatment apparatus which is free of wounds, low in cost, convenient to use and practical is provided.
Description
Technical field
The present invention relates to biomedical engineering technology field, specifically a kind of near-infrared light therapeutic apparatus that is used for the treatment of disease of brain.
Background technology
The kind of brain diseases was more and more in the last few years, and sickness rate is also more and more higher, such as apoplexy, wound hindbrain dysfunction disease, juvenile's hyperkinetic syndrome, depression, reading disorder, amnesia, climacteric syndrome, senile dementia etc.Brain function disease is increasing to the harm of human health, and it not only affects patient's life-span and quality of the life/situation, even affects patient's family's wellbeing.People are also increasing to the demand of brain diseases prevention and treatment.Primary treatment method is Drug therapy or operative treatment at present, also has the auxiliary treatment such as health preservation treatment, Chinese traditional treatment.Drug therapy can have side effects, toxic reaction, allergy, secondary response, after effect and teratogenesis, to the injury of human body, is immeasurable.Operative treatment belongs to wound treatment, very big to the injury of human brain, and its sequela all likely causes that patient limb numbness, pain, motion are ineffective, dysphonia at any time, even the situation such as cerebral palsy.The curative effect of health therapy and tcm therapy is also at present extensively not to be approved or indefinite uncontrollable stage of curative effect.Brain function disease treatment needs new better technology.
Along with scientific and technological development and progress, and the attention of people to brain health, emerging therapeutic modality also produces thereupon.Start at present the new treatment means coming into the market, have magnetic resonance treatment, infrared therapy.But these treatments have some drawbacks: magnetic resonance treatment fails because its condition is limited to popularize and come in most of crowd, has the harm of ionizing radiation to human body, and has the people of metal not use in health; Infrared therapy, is the treatment based on heat effect, is not essence treatment, cannot reach treatment Expected Results.
At present in the relevant patent application that belongs to novel disease of brain treatment technology, there is one to be with electromagnetic wave, brain diseases to be treated, be patent of invention WO2011072472A1, this patent adopts 532nm, 980nm, 1470nm, 2000nm and the radiation of 2100nm wavelengths of electromagnetic to realize treatment, mainly utilize hotwork to be used for treating, different from the present invention.Another related invention patent CN102186538A, treats brain by producing pulse electromagnetic field, different from the technology of the present invention treatment mechanism equally, and its restriction of body treatment existence condition to people, also be with radiation injury, and specification requirement is high, treatment facility is expensive.
Summary of the invention
The object of the invention is to solve the defect that above-mentioned prior art exists, a kind of instrument of noninvasive light treatment brain function disease is provided, this instrument is irradiated to brain inner disease foci tissue regions, exposure rate, irradiation duration and flicker frequency by adjusting, make light with certain intensity and flicker frequency, be irradiated to the focus of appointment, on the one hand, make mitochondrion and the related enzyme activity in this region raise or roll up, thereby cause a series of stronger physiological reactions, and then repair injured neurons; On the other hand, irradiate the hematodinamics in this region is strengthened, also further promote the reparation in focus region, thus to hyperkinetic syndrome, depression, the disease of brain such as apoplexy and climacteric syndrome produce significant curative effect.
We propose a kind of invention based near infrared light treatment brain function disease.This technology, by the irradiation of near infrared light, utilizes its photoelectricity biological effect to enliven the mitochondrion of brain specific part, thereby improves the metabolism of enzyme, makes cell regeneration carry out repair of neuron tissue; Near infrared light can also promote the absorption of local exudate simultaneously, distends the blood vessels, and blood flow accelerates, there is the sanguimotor effect of obvious enhancing, the thromboembolism in dredging focus region, and strengthen disease of brain and repair the supply of necessary blood oxygen and metabolism, to produce significant therapeutic effect.We are incorporated near infrared light in the middle of the treatment of header functionality disease originally, and the therapeutic equipments of a kind of noninvasive, with low cost, convenient and practical brain function disease is provided.
Accompanying drawing explanation
Fig. 1 is near-infrared light therapeutic apparatus structural representation of the present invention;
Fig. 2 is the connection layout of sphere shape light carrier of the present invention;
Fig. 3 is the scattergram one (R=15mm, LED is radial and arranges, and comprises 13 LEDs) of light source in light source carrier of the present invention;
Fig. 4 is the scattergram two (R=15mm, LED is determinant and arranges, and comprises 11 LEDs) of light source in light source carrier of the present invention;
Fig. 5 is the scattergram three (R=20mm, LED is radial and arranges, and comprises 19 LEDs) of light source in light source carrier of the present invention;
Fig. 6 is the scattergram four (R=20mm, LED is determinant and arranges, and comprises 16 LEDs) of light source in light source carrier of the present invention;
Fig. 7 is polygon optical source carrier of the present invention and distribution of light sources schematic diagram thereof;
Fig. 8 is therapeutic instrument using state figure of the present invention;
The specific embodiment
For making the object, technical solutions and advantages of the present invention clearer, below technical scheme in the present invention be clearly and completely described, obviously, described embodiment is the present invention's part embodiment, rather than whole embodiment.Embodiment based in the present invention, those of ordinary skills, not making the every other embodiment obtaining under creative work prerequisite, belong to the scope of protection of the invention.
The invention provides a kind of near-infrared light therapeutic apparatus, comprise and can launch the light source of near infrared light, the carrier of light source, human-computer interaction module and the power module of the hemisphere face support of immobilization carrier, the driver that drives described light source luminescent, the signal controller that light source is provided for providing to driver, the output of whole system input information.Described light source maximum illumination scope covers whole head, comprises whole forehead, and lower neat brow ridge, holds temple, the crown, the back side of head, lower neat cervical region upper limb.
The shape of light source carrier of the present invention can be circular, and the diameter of described round carrier is 20mm～60mm, and for not adding crooked carrier, its diameter preferred value is 20mm～30mm; When the diameter of round carrier is 30mm～60mm, by increasing certain flexibility, to improve the laminating degree with brain outer surface, crooked radius of curvature should be greater than the several times of nahlock radius, and this multiple scope should be greater than 2.
The shape of light source carrier of the present invention can also be polygon, and the length of side of described polygon carrier is 0mm～60mm, and for not adding crooked polygon carrier, the length of side of polygon carrier is preferably 10mm～30mm.When the length of side of polygon carrier is 30mm～60mm, by increasing certain flexibility, to improve the laminating degree with brain outer surface, crooked radius of curvature should be greater than the several times of the long-diagonal of polygon, and this multiple scope should be greater than 2.
The carrier of light source of the present invention can be used the hole in line and light source carrier to interconnect, and carrier is conspired to create to the planar near-infrared light source support of hemisphere, and described line can adopt elasticity and non-elastic material.Described hole is positioned on carrier, for round carrier, and pitch-row circumference 3mm～5mm, diameter is 0.5mm～2mm, and every round carrier comprises 6 holes, and the angle of adjacent two holes and circle center line connecting is 60 °; For polygon carrier, hole is positioned on the perpendicular bisector on every limit, and apart from limit 3mm～5mm, diameter is 0.5mm～2mm.
The carrier of light source of the present invention can also embed with in the planar support of the hemisphere of circular hollow out or polygon hollow out.The material of the planar support of hemisphere can be elasticity and stiff.For circular hollow out support, the spherical distance between the adjacent two circular hollow out centers of circle is 2R+1mm～2R+10mm (radius that R is circular hollow out); For polygon hollow out, two adjacent polygon adjacent edge spacings are 1mm～10mm, and representative value is 3mm～8mm.
More than one near-infrared light source is distributing on the carrier of described light source.Described near-infrared light source can adopt integrated near-infrared LED, also can adopt fiber-optic transfer near infrared light and pass through the diffusion sheet scattering formation light source identical with shape with light source carrier projected area.
Described near-infrared light source can be arranged in ranks in light source carrier, two adjacent light sources spacing 5mm～15mm, and outermost layer light source is 3mm～8mm apart from the distance on circumference or polygon limit.
Described near-infrared light source can also be radially distributed in light source carrier with concentric circular.For round carrier, outermost layer light source is 3mm～8mm apart from the distance of circumference, and preferred value is 4mm, 5mm; Adjacent two layers light source distance is radially 5mm～8mm, and preferred value is 5mm, 6mm, 7mm; The angle of each layer of two adjacent light sources and circle center line connecting is 10 °～120 °, and preferred value is 10 °, 15 °, and 30 °, 40 °, 60 °, 90 °, 120 °; For polygon carrier, its distance of closing on limit of outermost layer light source distance is 3mm～8mm, and preferred value is 4mm, 5mm; Adjacent two layers light source distance is radially 5mm～8mm, and preferred value is 5mm, 6mm, 7mm; The angle of each layer of two adjacent light sources and the polygon line of centres is 10 °～120 °, and representative value is 10 °, 15 °, and 30 °, 40 °, 60 °, 90 °, 120 °.
Described near-infrared light source links together with serial or parallel connection or connection in series-parallel combination on carrier, and draws by a unified driving interface, and described driving interface is positioned at the non-LED face of carrier.
Described near-infrared light source wave-length coverage is 600nm～900nm, and preferred value is 780nm～850nm.
Described driver of the present invention, for driving light source, makes light source transmitting near infrared ray.Its outfan drives interface to be connected with described light source carrier, and input is connected with controller.Described driver comprises that simulation dim signal generator or digital dimming signal generator or both comprise simultaneously.
The input signal of man-machine interaction is accepted and processed to described controller, for the signal of controlling light source is provided to driver,, and display shows signal etc. is provided.Controller is connected with driver with simulation dimming interface by digital dimming interface, by address wire, is connected with human-computer interaction module with data wire.
Human-computer interaction module of the present invention comprises information input equipment and information output device.The input message of described information input equipment comprises the controller decision signal such as light source light on and off state, brightness, flicker frequency, exposure time, the status information of information output device display device, comprises size of current, flicker frequency, light on and off state, postdose time and the patient information etc. of light source; Input information outut device can be connected by wired or wireless mode with controller.
Power module of the present invention comprises main power source and accessory power supply, and main power source is driver power supply, and accessory power supply is other equipment power supplies except driver.
Embodiment 1:
In the present embodiment, adopt nahlock circuit board as light source carrier, adopt near-infrared luminous LED as near-infrared light source, by the hole on nahlock circuit board, use elastic threads that module is concatenated into helmet-like.The diameter of the nahlock circuit board adopting is 15mm.
The connected mode of having shown nahlock circuit board in Fig. 2.As shown in Figure 2, on every circuit board, there are six circular holes, the distance D 1 of each hole distance of center circle circuit board circumference, span should meet 1.5mm≤D1≤3mm, Circularhole diameter r1, span should meet 0.5mm≤r1≤2mm, and the angle between adjacent two circular holes and circuit board circle center line connecting is 60 °.Circuit board is interconnected to form LED light source carrier by the elastic threads through circular hole.Need altogether 59 nahlock circuit boards.
In the present embodiment, the LED on every nahlock circuit board distributes and presses concentric circular radial arrangement, needs altogether 13 LEDs, forms near infrared light emission array.As shown in Figure 3, LED adopts radial arranging, wherein, D3 be outermost layer LED apart from the distance of circumference, span should meet 3mm≤D3≤8mm, representative value is 4mm, 5mm; D2 is adjacent two layers LED distance radially, and span should meet 5mm≤D2≤8mm, and representative value is 5mm, 6mm, 7mm; In the present embodiment, three layers of LED light source distribute on every nahlock circuit board.α, β are respectively the angle of outermost layer two LEDs adjacent with inferior skin and circle center line connecting, α=40 °, β=120 °.All LED on every nahlock circuit board adopt series system to connect.
The driver of the present embodiment adopts integrated LED to drive chip, maximum 3 passage outputs, and each passage can drive all LED on a nahlock circuit board.Chip comprises that 3 are independently simulated light modulation port and 3 number tone of Chinese characters optical ports, by adjusting, simulate electric current (voltage) size (being the brightness of LED) of the voltage swing control respective channel on light modulation port, by the level on control figure light modulation port, just control the switch of respective channel, be the light on and off of LED, by at this passage input certain frequency square wave, realize LED flicker.
The present embodiment comprises 59 nahlock circuit boards, and Gong Xu 59 separate analogue voltage signal He59 road, tunnel independent digit square-wave signals are controlled in order to simulate light modulation and light on and off respectively.
Analog voltage signal coordinates controller to produce by 3-8 decoder and 8 DA chips of 8 passages, in the present embodiment, share 1 3-8 decoder and 8 above-mentioned DA chips, 8 public 8 bit data bus of DA, by geocoding, make once can only a slice DA a passage can obtain the data on data/address bus.Each output of 3-8 decoder is connected to the conversion and control pin of a slice DA chip.Three address input ends (as sheet choosing) for 3-8 decoder, 8 outfans of codified, for an address input, only have an outfan effective, the corresponding DA chip that is connected to repeatedly this also enables DA conversion, DA chip also has 3 address input ends (as position choosing), 8 the DA ALT-CH alternate channels of encoding.64 DA output channels of 6 address bits codings can be passed through, and then independently voltage signal of 64 tunnels can be produced.
Digital square-wave coordinates controller to realize by 3-8 decoder and 8 latch chips.The public 1 3-8 decoder of the present embodiment and 88 latch, 8 latch share 8 bit data bus, by geocoding, make on a certain moment data/address bus data can only output on the outfan of a slice latch.Each output of 3-8 decoder is connected to a slice latch chip clock pin.Three address input ends for 3-8 decoder, 8 outfans of codified, for an address input, only have an outfan effective, when this output is become while being effectively from invalid, on the clock pin of latch chip that is connected to this pin, produce a clock edge, this clock reaches outfan by 8 for inputting data along triggering latch, when above-mentioned significance bit becomes when invalid again, produce a rightabout clock edge, make latch output no longer follow latch input, therefore can decide output by having or not of clock edge is change or keep, can produce altogether independent 64 railway digital square-wave signals.
The controller of the present embodiment adopts single-chip microcomputer as control core, by programme-control universal I/O port, address input (comprising sheet choosing and position choosing) and data input as digital square-wave generation module and analog voltage signal generation module, realize the light on and off of every nahlock circuit onboard led and the control of brightness.
Human-computer interaction module is comprised of keyboard and display, and keyboard adopts 4x4 matrix keyboard, and keyboard driver adopts line scanning method.Display can adopt OLED display screen.
Power module of the present invention, comprises main power source and accessory power supply.Main power source offers integrated LED driver and accessory power supply uses, and required voltage is higher, adopts the switch power module of 220V input 36V output; Accessory power supply is mainly used in controller, keyboard and monitor power supply, and voltage ratio is lower, adopts three terminal regulator to obtain from main power source blood pressure lowering.
Embodiment 2:
The present embodiment adopts LED arrangement mode as shown in Figure 4, and other parts are identical with embodiment 1.
Embodiment 3:
The present embodiment adopts LED arrangement mode as shown in Figure 5, and radius R=20 of nahlock circuit board, and other parts are identical with embodiment 1.
Embodiment 4:
The present embodiment adopts LED arrangement mode as shown in Figure 6, and radius R=20 of nahlock circuit board, and other parts are identical with embodiment 1.
Embodiment 5:
The light source carrier of the present embodiment adopts polygon optical source carrier, and distribution of light sources adopts the radial distribution of concentric circular, and other parts are identical with embodiment 1.As shown in Figure 7.
Embodiment 6:
The human-computer interaction module of the present embodiment adopts touch screen to replace keyboard and the display in embodiment 1, and other parts are identical with embodiment 1.
Embodiment 7:
The human-computer interaction module of the present embodiment adopts PC to realize, and realizes the exchange of information between PC and microcontroller by UART.As Fig. 8.
Embodiment 8:
The human-computer interaction module of the present embodiment adopts mobile phone to realize, mobile phone with for communicating by letter by bluetooth or WiFi realization between controller.
What near infrared ray of the present invention mainly adopted is photoelectricity biological effect, is exactly a bit specifically: utilize its photoelectricity biological effect to enliven the mitochondrion of brain specific part, thereby improve the metabolism of enzyme, make cell regeneration carry out repair of neuron tissue; Near infrared light can also promote the absorption of local exudate simultaneously, distends the blood vessels, and blood flow accelerates, and has the sanguimotor effect of obvious enhancing, the thromboembolism in dredging focus region, and enhancing disease of brain are repaired the supply of necessary blood oxygen and metabolism.
Finally it should be noted that: above embodiment only, in order to technical scheme of the present invention to be described, is not intended to limit; Although the present invention is had been described in detail with reference to previous embodiment, those of ordinary skill in the art is to be understood that: its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement; And these modifications or replacement do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (10)
1. a near-infrared light therapeutic apparatus, it is characterized in that, comprise the light source that can launch near infrared light, the carrier of light source, the hemisphere face support of immobilization carrier, drive the driver of described light source luminescent, for the signal controller of controlling light source is provided to driver, defeated human-computer interaction module and the power module of input information of whole system, described human-computer interaction module is connected with the input of controller, the outfan of controller is connected with the input of driver, the outfan of driver is connected with light source, described power module and driver, controller, human-computer interaction module connects, described light source range of exposures covers whole forehead, and lower neat brow ridge, holds temple, the crown, and the back side of head, lower neat cervical region upper limb, the wave-length coverage of described light source is 600nm～900nm.
2. near-infrared light therapeutic apparatus according to claim 1, is characterized in that, the support shapes of described light source is circular, and the diameter of this round carrier is 20mm～60mm; For not adding crooked round carrier, preferably diameter is 20mm～30mm; Diameter is the round carrier of 30mm～60mm, and by increasing certain flexibility, to improve the laminating degree with brain outer surface, crooked radius of curvature is the more than 2 times of nahlock radius.
3. near-infrared light therapeutic apparatus according to claim 1, is characterized in that, the support shapes of described light source is polygon, and the length of side of this polygon carrier is 0mm～60mm; For not adding crooked polygon carrier, preferably the length of side is 10mm～30mm; The length of side is the polygon carrier of 30mm～60mm, and by increasing certain flexibility, to improve the laminating degree with brain outer surface, crooked radius of curvature is greater than the more than 2 times of long-diagonal of polygon.
4. according to the near-infrared light therapeutic apparatus described in claim 2 or 3, it is characterized in that, comprise the carrier of some light sources, between the carrier of light source, use the hole on line and carrier to interconnect, the carrier of light source is conspired to create to the planar support of hemisphere.
5. near-infrared light therapeutic apparatus according to claim 4, is characterized in that, for circular carrier, and pitch-row circumference 1.5mm～5mm, bore dia is 0.5mm～2mm, and every round carrier comprises 6 holes, and the angle of adjacent two holes and circle center line connecting is 60 °; For polygon carrier, hole is positioned on the perpendicular bisector on every limit, pitch-row limit 3mm～5mm, and bore dia is 0.5mm～2mm.
6. according to the near-infrared light therapeutic apparatus described in claim 2 or 3, it is characterized in that, the carrier of described light source embeds with in the planar support of the hemisphere of circular hollow out or polygon hollow out, and the material of the planar support of hemisphere can be elasticity or stiff; For circular hollow out support, the spherical distance between the adjacent two circular hollow out centers of circle is 2R+1mm～2R+10mm, the radius that R is circular hollow out; For polygon hollow out support, two adjacent polygon adjacent edge spacings are 1mm～10mm, are preferably 3mm～8mm.
7. according to the near-infrared light therapeutic apparatus described in claim 2 or 3, it is characterized in that, on described carrier, be distributed with more than one near-infrared light source, described near-infrared light source adopts integrated near-infrared LED, or adopts fiber-optic transfer near infrared light and pass through the diffusion sheet scattering formation light source identical with shape with light source carrier projected area.
8. according to the near-infrared light therapeutic apparatus described in claim 2 or 3, it is characterized in that, described near-infrared light source is arranged in ranks in light source carrier, two adjacent light sources spacing 5mm～15mm, and outermost layer light source is 3mm～8mm apart from the distance on circumference or polygon limit; Or
Described near-infrared light source is radially distributed in light source carrier with concentric circular, and for round carrier, outermost layer light source is 3mm～8mm apart from the distance of circumference, be preferably 4mm or 5mm, adjacent two layers light source distance is radially 5mm～8mm, is preferably 5mm or 6mm or 7mm, the angle of each layer of two adjacent light sources and circle center line connecting is 10 °～120 °, be preferably 10 °, 15 °, 30 °, 40 °, 60 °, 90 °, 120 °; For polygon carrier, it closes on the distance 3mm～8mm on limit outermost layer light source distance, and preferred value is 4mm or 5mm; Adjacent two layers light source distance is radially 5mm～8mm, and preferred value is 5mm or 6mm or 7mm, and the angle of each layer of two adjacent light sources and the polygon line of centres is 10 °～120 °, or value is 10 °, 15 °, and 30 °, 40 °, 60 °, 90 °, 120 °.
9. near-infrared light therapeutic apparatus according to claim 8, it is characterized in that, described near-infrared light source links together with serial or parallel connection or connection in series-parallel combination on carrier, and draws by a unified driving interface, and described driving interface is positioned at the non-LED face of carrier.
10. near-infrared light therapeutic apparatus according to claim 1, is characterized in that, the wave-length coverage of described light source is 780nm～850nm.
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| CN201410450333.4A CN104162233A (en) | 2014-09-04 | 2014-09-04 | Near-infrared light therapeutic apparatus for treating brain diseases |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984484A (en) * | 2015-07-28 | 2015-10-21 | 燕山大学 | Closed loop-type near-infrared brain stimulation device |
| CN105126256A (en) * | 2015-09-24 | 2015-12-09 | 黄勇 | Near-infrared light illumination treatment device used for treating Alzheimer's disease |
| CN105381547A (en) * | 2015-11-11 | 2016-03-09 | 杨跃华 | LED chest protection device |
| CN107019849A (en) * | 2017-03-27 | 2017-08-08 | 关夫 | The portable therapeutic device of Alzheimer disease is treated using light stimulus optic nerve |
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2014
- 2014-09-04 CN CN201410450333.4A patent/CN104162233A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984484A (en) * | 2015-07-28 | 2015-10-21 | 燕山大学 | Closed loop-type near-infrared brain stimulation device |
| CN105126256A (en) * | 2015-09-24 | 2015-12-09 | 黄勇 | Near-infrared light illumination treatment device used for treating Alzheimer's disease |
| CN105126256B (en) * | 2015-09-24 | 2017-06-23 | 黄勇 | A kind of near-infrared light therapy device for treating alzheimer disease |
| CN105381547A (en) * | 2015-11-11 | 2016-03-09 | 杨跃华 | LED chest protection device |
| CN107019849A (en) * | 2017-03-27 | 2017-08-08 | 关夫 | The portable therapeutic device of Alzheimer disease is treated using light stimulus optic nerve |
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Application publication date: 20141126 |