CN104161525A - Composition measuring device and composition measuring method - Google Patents
Composition measuring device and composition measuring method Download PDFInfo
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- CN104161525A CN104161525A CN201310184629.1A CN201310184629A CN104161525A CN 104161525 A CN104161525 A CN 104161525A CN 201310184629 A CN201310184629 A CN 201310184629A CN 104161525 A CN104161525 A CN 104161525A
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Abstract
The invention provides a composition measuring device and a composition measuring method. The composition measuring device selectively radiates one kind of radiation light (E) among various kinds of radiation light with different light splitting radiation characters, and the concentration of composition is quantified according to a plurality of detecting signals obtained based on the types of the radiation light (E) respectively. The quantified concentration is modified according to the measured body temperature.
Description
Technical field
The present invention relates to a kind of component measuring device and composition measurement method of measuring the composition in detected body.
Background technology
About the caused diseases due to habit disturbance of daily living habit, for example diabetes, for the outbreak avoid hypoglycemia symptom or complication in advance, patient wish the blood glucose value to oneself always through time variation monitor.Widely used all types of blood-glucose meter is all the blood measuring blood glucose value gathering by puncture patient skin now.But this puncture procedure burden of health for patient is larger, and may cause infection by puncture needle.Therefore, recently, there is the measuring method of the various Noninvasives that do not need blood sampling to be developed.
For example, in patent documentation 1, propose to have following apparatus and method: to tympanum radiation infrared light, according to the measurement amount blood glucose value of the light through its skin layer reflection.Be more particularly that the filter wheel with two kinds of optical filters is configured in to the position before infrared detector, carry out quantitatively according to the reflected light of the optical filter that sees through one party is detected to two kinds of detection signals that obtain.
Patent documentation 1: TOHKEMY 2009-201853 communique ([0053]-[0066] section, Fig. 2)
But, this measuring method and so-called spectrographic method comparison, the obtained quantity of information (data bulk) of measurement by is once less, therefore, may not guarantee fully quantitative accuracy.Find according to the present inventor's concentrated research: if little by little variation has occurred the body temperature of detected body, also can become large because the difference of the kind of Measurement Algorithm causes measurement error.
Summary of the invention
It the present invention seeks to provide in order to address the above problem a kind of component measuring device and composition measurement method, even if in the case of the body temperature change of detected body, also can measure the concentration of the composition in detected body accurately.
Component measuring device of the present invention, it has: radiation unit, this radiation unit is radiated a kind of radiating light in the multiple radiating light that light splitting radioactive nature is different selectively; Light receiving unit, this light receiving unit is accepted reflected light and is obtained the detection signal that represents described catoptrical light quantity, the body surface that the radiating light being radiated by described radiation unit is projected detected body by this reflected light obtains, and this reflected light is relevant to the composition in described detected body; Concentration quantitative unit, this concentration quantitative unit carrys out the concentration of quantitative described composition according to the multiple described reflected light detection signal obtaining respectively according to the kind of each described radiating light; Measurement of bldy temperature unit, the body temperature of described detected body is measured in this measurement of bldy temperature unit; Concentration correction unit, this concentration correction unit adopts the body temperature of being measured by described measurement of bldy temperature unit, to being revised by the quantitative concentration in described concentration quantitative unit.
Like this, owing to being provided with according to the concentration quantitative unit of the concentration of the quantitative composition of multiple detection signals obtaining respectively according to each radiative kind, measuring the measurement of bldy temperature unit of the body temperature that is detected body and adopt the described body temperature of measuring to the concentration correction unit of revising by the quantitative described concentration in described concentration quantitative unit, so, even if in the case of the body temperature variation of detected body, also can measure accurately the concentration of the composition in detected body.
In addition, under the state that described measurement of bldy temperature unit stops in the radiation of the described radiating light being undertaken by described radiation unit, according to received by described light receiving unit from body temperature described in the photo measure of described detected body.Thus, clinical thermometer needn't be set in addition and just can measure the body temperature that is detected body.
In addition point optical absorption characteristics that, described at least one in described multiple radiating light, the peak wavelength of the described light splitting radioactive nature of radiating light belongs to described composition is 0 or the wave-length coverage wavelength as a comparison of negative value.By using in the lump, to contain much more relatively point optical absorption characteristics be 0 or the radiating light of the wavelength components of negative value, and the quantitative accuracy of concentration is uprised.
In addition, described radiation unit is multiple light sources that described light splitting radioactive nature is different, controls selectively a kind of light source in described multiple light source.
In addition, described radiation unit has bandpass characteristics different multiple optical filter and light source, configures selectively a kind of optical filter in described multiple optical filter in the light path of described light source.
In addition, also there is measuring tube, this measuring tube comprises the cylindrical portion from tip side to base end side enlarged diameter and the bellying bloating to radial outside at the base end side of described cylindrical portion, by described measuring tube, carries out projection and the described catoptrical reception of described radiating light.
In addition, composition measurement method of the present invention, adopts above-mentioned any component measuring device to measure the composition in detected body.In addition,, as described composition, measure blood glucose value or glycolated hemoglobin concentration etc. below tympanum or the tongue of described detected body.
Invention effect:
According to component measuring device of the present invention and composition measurement method, due to according to the concentration of the quantitative composition of multiple detection signals that obtains according to the kind of each radiating light, the body temperature correction concentration of the detected body that employing is measured, so, even if also can measure accurately the concentration of the composition in detected body in the case of the body temperature variation of detected body.
Brief description of the drawings
Fig. 1 is the axonometric chart as the blood-glucose meter of the component measuring device of this embodiment.
Fig. 2 is the electrical diagram of the blood-glucose meter shown in Fig. 1.
Fig. 3 is the functional block diagram of the calculating part shown in Fig. 2.
Fig. 4 is the flow chart for the mensuration explanation of blood-glucose meter shown in Fig. 1.
Fig. 5 is the curve chart that represents point optical absorption characteristics of glucose.
Fig. 6 is the curve chart that represents point optical absorption characteristics of the glucose of following concentration change.
Fig. 7 represents the curve chart of blood glucose value for an example of the characteristic of body temperature.
Fig. 8 is the electrical diagram of the blood-glucose meter of variation.
Detailed description of the invention
Below, about composition measurement method of the present invention, enumerate and implement the embodiment of the good relationship of the component measuring device of this composition measurement method, describe with reference to accompanying drawing.
The structure (blood-glucose meter 10) of this embodiment:
Fig. 1 is the axonometric chart as the blood-glucose meter 10 of the component measuring device of this embodiment.Blood-glucose meter 10 has: rectangular-shaped main body 12, be arranged on main body 12 sides measuring tube 14, be arranged on the positive upside of main body 12 display 16, be arranged near the on and off switch 18 central authorities in this front and measure switch 20.
Measuring tube 14 has: by tip side to the cylindrical portion 22 of the bottomless truncated cone shape of base end side enlarged diameter and the bellying 24 that bloats to radial outside at the base end side of cylindrical portion 22.Thus, be formed with the end difference 26 of ring-type at the outer surface of measuring tube 14.In addition, be provided with measurement window 28 in the top ends of measuring tube 14, measure time carry out radiating light E(Fig. 2 by this measurement window 28) projection and reflected light R(Fig. 2) reception.
Display 16 except showing measuring blood value as measurement result, also show with guiding, the treatment of operating procedure instruct, generation make mistakes content with and the relevant various information of processing method.Display 16 is can white and black displays or can the colored display module showing, it can be by liquid crystal panel, organic EL(electroluminescent), the formation such as inorganic EL panel.
On and off switch 18 is that opening/closing is from power circuit 68(Fig. 2) the switch of supply use of power supply.Measuring switch 20 is by measuring optical system 34(Fig. 2) indicate blood glucose measurement to start the switch of use.
The internal structure of measuring tube 14:
Fig. 2 is the electrical diagram of the blood-glucose meter 10 shown in Fig. 1.The local amplification sectional view of measuring tube 14 is shown in the left side of this figure., suppose following situation herein: the external auditory meatus 30 to detected body is inserted measuring tube 14, measuring tube 14 is connected under the state of inwall 31 of ear, carries out near measurement tympanum 32.
Blood-glucose meter 10 has the optical system 34 of measurement, and this measurement optical system 34 is to body surface (more particularly, the being tympanum 32) projection light of detected body, the light (following, to be reflected light R) of detection process skin reflex.Measuring optical system 34 has: the radioactive department 36(radiation unit of sending radiating light E), by the fibre bundle 38b of radiating light E orientation measurement window 28, to the light guiding parts 40 leading by the reflected light R of measurement window 28 incidents and receive the light accepting part 42(light receiving unit of the reflected light R that leads by light guiding parts 40).
Radioactive department 36 has: the light source (in this legend, being three kinds of light source 44a, 44b, 44c) of multiple kinds and receive respectively the housing 46 of light source 44a-44c.The different light (for example, comprising the infrared light of near infrared ray, middle infrared (Mid-IR)) of each light source 44a-44c radiation light splitting radioactive nature.For example, the peak wavelength λ 1 of light source 44a is λ 1=1950nm, and the peak wavelength λ 2 of light source 44b is λ 2=2140nm, and the peak wavelength λ 3 of light source 44c is λ 3=2260nm.Light source 44a-44c also can adopt and comprise LED(light emitting diode) element, organic EL(electroluminescent) the various light-emitting components of element, inorganic EL element, laser diode.
The housing 46 being made up of the material with light-proofness has one to make its inner chamber 48 and the outside intercommunicating pore 50 being communicated with.In addition, housing 46 be also by the radiating light E optically focused from light source 44a-44c near intercommunicating pore 50.
Fibre bundle 38b ties up an end of multiple optical fiber 38 to form.The base end side (side being tied) of fibre bundle 38b is connected with housing 46 by intercommunicating pore 50.
Light guiding parts 40 has the double-sleeve structure being made up of outer tube 51 and inner tube 52.Thus, between outer tube 51 and inner tube 52, form the first space 54, and form second space 55 in the inner side of inner tube 52.At the base end side of light guiding parts 40, thereby by inner tube 52 being arranged to than the short formation of outer tube 51 clearance portion 58, clearance portion 58 is embedded with the tip side of light accepting part 42.This light accepting part 42 is made up of the photo detector in the wave-length coverage of each light source 44a-44c with sensory characteristic.Also can adopt and comprise PD(photodiode as light accepting part 42) the various photo-electric conversion elements of element, photocon (light electric conductor), photoelectric crystal tube elements (PT).
Be provided with the first space 54 and the outside intercommunicating pore 56 being communicated with that make light guiding parts 40 at outer tube 51.The top ends of each optical fiber 38 is inserted intercommunicating pore 56, and is accommodated in respectively in the first space 54.Thus, each optical fiber 38 is along the central shaft arrangement of outer tube 51 and inner tube 52, and each top ends is pointed to respectively tympanum 32 sides.
Next, the effect of this measuring tube 14 is described.From the radiating light E process chamber 48 of housing 46 and the base end side of intercommunicating pore 50 guiding fiber bundle 38b of light source 44a-44c radiation.In addition, radiating light E, by the inside of each optical fiber 38, penetrates from the tip side of each optical fiber 38, projects to tympanum 32.
In addition, radiating light E is near the process skin reflex of of tympanum 32.At the blood vessel (not mark) of the near surface of tympanum 32, by a part of the glucose absorption radiating light E in blood.Glucose has the characteristic that point optical absorption characteristics becomes component (for example concentration) to change according to it.In other words, have and the concentration dependent dichroism of glucose from the reflected light R of tympanum 32.
In addition, reflected light R, being directed to behind the inside of inner tube 52 of light guiding parts 40, by second space 55, receives light by light accepting part 42.Like this, due to the bearing of trend (optical axis of light irradiation E) in the first space 54 and the bearing of trend (optical axis of reflected light R) of second space 55 parallel, so, can reduce the fluctuation of the reflection angle at tympanum 32 places, improve the light gathering efficiency of reflected light R.
The electrical diagram of blood-glucose meter 10:
As shown in Figure 2, blood-glucose meter 10, except above-described measuring tube 14, display 16, on and off switch 18, measurement switch 20, measurement optical system 34, also has calculating part 60, memorizer 62, illuminating circuit 64, light receiving circuit 66, power circuit 68.
Calculating part 60 is by MPU(microprocessing unit) or CPU(CPU) form, by reading and carry out the program that is stored in memorizer 62 etc., can realize the control action of each several part.Memorizer 62 is volatibility or non-volatile storage medium, can read or writes for implementing the required various data (comprising program) of this composition measurement method.
Illuminating circuit 64 passes through to supply with driving electric signal to each light source 44a-44c, thereby makes light source 44a-44c light or extinguish.Light receiving circuit 66 is implemented A/D conversion by the analogue signal to exporting from light accepting part 42 and is obtained digital signal (following, to be called detection signal).Power circuit 68 is according on and off switch 18(Fig. 1) operation, to comprising that the each several part in the blood-glucose meter 10 of calculating part 60 supplies with electric power or stop this supply.
The functional block diagram of calculating part 60:
Fig. 3 is the functional block diagram of the calculating part 60 shown in Fig. 2.Calculating part 60 is realized the function of following portion: decision is from the supply target determination section 80 of the supply target (terminal 80a, the 80b of linking objective) of the detection signal of light receiving circuit 66; Detect the detected value calculating part 82 of the detected value relevant to the composition of glucose etc. according to specific detection signal; According to the 84(of the concentration quantitative portion concentration quantitative unit of the concentration of the quantitative composition of multiple detected values obtaining according to the kind of each radiating light E); Measure tympanum 32(Fig. 2 according to specific detection signal) 86(of the measurement of bldy temperature portion measurement of bldy temperature unit of the body temperature of periphery); And adopt the 88(of the concentration correction portion concentration correction unit of the concentration that the body temperature correction of measuring quantifies).
In addition, calculating part 60 beginning that also oriented illuminating circuit 64 instructions are measured and instruction supply target determination section 80 determine the effect of the measurement instruction unit 90 of action.
The measuring process of blood-glucose meter 10:
As mentioned above, form the blood-glucose meter 10 of this embodiment.Next,, about the running of blood-glucose meter 10, mainly describe with reference to the flow chart of Fig. 4 and the functional block diagram of Fig. 3.
As prepare in advance, open on and off switch 18(Fig. 1 of blood-glucose meter 10), measuring tube 14 is inserted as the people's of detected body ear (external auditory meatus 30).Then, measure switch 20 by pressing, make blood-glucose meter 10 start the measurement of blood glucose value.
As shown in Figure 1 and Figure 2, because the outer surface of measuring tube 14 is provided with the end difference 26 of ring-type, so, measuring tube 14 being connected under the state of inwall 31 of ear, can stably keep measuring position, the posture of optical system 34.Thus, can reduce the caused measurement error of fluctuation of the angle of reflected light R.
In addition, as the position of measuring object, be not limited to above-mentioned tympanum 32, for example also can select below tongue.Its reason is, these two positions all have advantages of measurement aspect as described below: the body temperature of (1) detected body is more stable, (2) rich blood vessel, and (3) epidermis is thin therefore the loss of light absorption is few, (4) can stably keep measuring tube 14, the impact of (5) exterior light is few.
At the step S1 of Fig. 4, detected value calculating part 82 calculates the detected value V1 of the first light splitting radioactive nature by measuring optical system 34.Here, so-called the first light splitting radioactive nature refers to the light splitting radioactive nature of light source 44a.
Before measuring, measure instruction unit 90 and start first measurement to illuminating circuit 64 instructions.Accept this instruction, illuminating circuit 64 is controlled, and makes selectively a kind of light source 44a in three kinds of light source 44a-44c light.,, according to above-mentioned, measure optical system 34 light quantity that the radiating light E being radiated by light source 44a is projected to the reflected light R that is detected the body surface (tympanum 32) of body and obtain is detected.
On the other hand, supply with target determination section 80 and be connected with terminal 80a according to the instruction of measuring instruction unit 90, will offer detected value calculating part 82 from the detection signal of light receiving circuit 66.In addition, detected value calculating part 82 calculates the detected value V1 of the light quantity that represents reflected light R according to the detection signal being supplied to.For example, be used as detected value V1 by for example calculating, by the statistical value (meansigma methods) of the each detected value measuring repeatedly, thereby can reduce the impact of statistical error.
In the situation that completing computing, measure instruction unit 90 and finish first measurement to illuminating circuit 64 instructions.Accept this instruction, illuminating circuit 64 extinguishes light source 44a by stopping the supply of driving electric signal.
At step S2, detected value calculating part 82 calculates the detected value V2 of the second light splitting radioactive nature by measuring optical system 34.Here, so-called the second light splitting radioactive nature refers to the light splitting radioactive nature of light source 44b.Except the different this point of used light source 44b, other are identical with step S1 in the action (second measurement) of the blood-glucose meter 10 in step S2, and therefore, the description thereof will be omitted.
At step S3, detected value calculating part 82 calculates the detected value V3 of the 3rd light splitting radioactive nature by measuring optical system 34.Here, so-called the 3rd light splitting radioactive nature refers to the light splitting radioactive nature of light source 44c.Except the different this point of used light source 44c, other are identical with step S1 and S2 in the action (the 3rd measurement) of the blood-glucose meter 10 in step S3, and therefore, the description thereof will be omitted.
At step S4, the body temperature of detected body is measured by measurement of bldy temperature portion 86.Before measuring, measure instruction unit 90 and start four measuring to illuminating circuit 64 instructions.Accept this instruction, the state that illuminating circuit 64 stops the supply of driving electric signal by maintenance, extinguishes light source 44a-44c.In addition, measuring optical system 34 detects from the ultrared light quantity of body surface (the especially surrounding position of the tympanum 32) radiation of detected body.
On the other hand, supply with target determination section 80 and be connected with terminal 80b according to the instruction of measuring instruction unit 90, will offer measurement of bldy temperature portion 86 from the detection signal of light receiving circuit 66.In addition, the body temperature T of detected body measures in measurement of bldy temperature portion 86 according to the detection signal (roughly wavelength region more than 5000nm) being supplied to.In this embodiment, utilize the measurement optical system 34 take temperature T for measuring blood value, but also can independent thermometer be set at measuring tube 14.
At step S5, concentration quantitative portion 84 is according to the concentration of the quantitative glucose of detected value V1-V3 calculating respectively in step S1-S3.Before quantitative Treatment, the quantitative coefficient being stored in advance in memorizer 62 is read by concentration quantitative portion 84.Blood glucose value g adopts detected value V1-V3 and quantitative curve F1() calculate according to formula (1) below.
g＝F1（V1，V2，V3） ‥‥（1）
Fig. 5 is the curve chart that represents point optical absorption characteristics of glucose.The transverse axis of curve chart is wavelength (unit: nm), and the longitudinal axis of curve chart is absorbance (unit: nothing).Here, absorbance is to define with the common logarithm of " inverse of spectral reflectance ".
Like this, about at least one the radiating light E(light source 44a in multiple radiating light E), point optical absorption characteristics that the peak wavelength λ 1 of its light splitting radioactive nature belongs to glucose is 0 or the wave-length coverage of negative value.Like this, by using in the lump, to have much more relatively point optical absorption characteristics be 0 or the radiating light E of the wavelength components of negative value, thereby the quantitative accuracy of the concentration (being blood glucose value) of glucose is uprised.
Fig. 6 is the curve chart that represents point optical absorption characteristics of the glucose of following concentration change.The transverse axis of curve chart is wavelength (unit: nm), and the longitudinal axis of curve chart is absorbance (unit: nothing).In this figure, the concentration (blood glucose value) that records in the lump glucose is respectively 100,1000,5000(mg/dL), 10,15(g/dL) the curve chart of five kinds.From this figure, regardless of blood sugar concentration, when λ=2136nm, 2168nm, absorbance is obtained maximum.
At step S6, the body temperature T of concentration correction portion 88 based on measuring in step S4 revises the concentration quantifying in step S5.Revised blood glucose value g ' is blood glucose value g and the fair curve F2(adopting before revising) calculate according to formula (2) below.In addition the body temperature (for example, 36 DEG C) that, To is standard.
g’＝F2（g，T／To） ‥‥（2）
Fig. 7 represents the curve chart of blood glucose value for an example of the characteristic of body temperature.The transverse axis of this curve chart is body temperature (unit: DEG C), and the longitudinal axis of curve chart is blood glucose value (unit: mg/dL).This curve chart is in the situation that for example detected body being assumed to be to black matrix, the curve chart obtaining by distortion Planck function.Here, blood glucose value (g) is monotonically increasing along with the increase of body temperature T.Can try to achieve fair curve F2(according to this variation characteristic).
At step S7, calculating part 60 makes display 16 display measurement results.Before display process, calculating part 60 has determined to make, after visual information that display 16 shows, the display control signal corresponding with this visual information to be offered to display 16 sides.In addition as visual information, for example, be not only blood glucose value, also can there are variation tendency, whether successfully measure, measure moment and diagnostic result etc.
As mentioned above, blood-glucose meter 10 completes after the measuring process of blood glucose value, takes out measuring tube 14, powered-down switch 18 from detected person's ear (external auditory meatus 30).
The effect of blood-glucose meter 10:
As mentioned above, blood-glucose meter 10 has: radioactive department 36, radiates a kind of radiating light E in the multiple radiating light that light splitting radioactive nature is different selectively; Light accepting part 42, receive reflected light R and obtain the detection signal of the light quantity that represents reflected light R, this reflected light R be radiating light E is projected to the body surface (for example tympanum 32) of detected body and obtain and for example, to the composition (glucose, glycolated hemoglobin) in detected body relevant; Concentration quantitative portion 84, according to the concentration of the next quantitative composition of the multiple detection signals that obtain respectively according to the kind of each radiating light E; Measurement of bldy temperature portion 86, measures the body temperature that is detected body; And concentration correction portion 88, adopt body temperature correction concentration.Thus, even in the case of the body temperature change of detected body, also can measure accurately the concentration of the composition in detected body.
The structure (blood-glucose meter 10A) of variation:
Next the blood-glucose meter 10A of variation is described.In addition, for the identical reference marks of the structure tag identical with above-mentioned embodiment, and the description thereof will be omitted.
Fig. 8 is the electrical diagram of the blood-glucose meter 10A of variation.Measure the radioactive department 102(radiation unit in optical system 100) structure and Fig. 2 shown in embodiment (with reference to radioactive department 36) difference.
Radioactive department 102 has: a light source 104; There is multiple optical filter (in this figure example, being that three kinds of optical filter 106a, 106b, 106c(are not shown)) discoideus filter switch boards 108; The motor 110 of installing at the Yi Gemian center of filter switch boards 108; And the optically focused parts 112 that are connected with the base end side of fibre bundle 38b.
The different band filter of bandpass characteristics (for example, comprising the infrared light of near infrared ray, middle infrared (Mid-IR)) that each optical filter 106a-106c is wavelength.For example, the central wavelength lambda 1 of optical filter 106a is λ 1=1950nm, and the central wavelength lambda 2 of optical filter 106b is λ 2=2140nm, and the central wavelength lambda 3 of optical filter 106c is λ 3=2260nm.
Emission control circuit 114 not only has illuminating circuit 64(Fig. 2) function, also can carry out in the lump and make filter switch boards 108 rotate the control of required angle by drive stepping motor 110.In addition, by making light source 104 and filter switch boards 108 meet the position relationship of regulation, thereby in the light path of light source 104, dispose selectively a kind of optical filter in multiple optical filter 106a-106c.
The measuring process of blood-glucose meter 10A:
As mentioned above, form the blood-glucose meter 10A of variation.Next,, about the measuring process of blood-glucose meter 10A, mainly describe with reference to the flow chart of Fig. 4 and the functional block diagram of Fig. 6.In addition, the measuring process of blood-glucose meter 10A and blood-glucose meter 10(Fig. 2) basic identical, but step S1-S3 difference.
At step S1, detected value calculating part 82 calculates the detected value V1 of the first light splitting radioactive nature by measuring optical system 100.Here, so-called the first light splitting radioactive nature refers to and in the light splitting radioactive nature of light source 104, is multiplied by the characteristic that the bandpass characteristics of optical filter 106a forms.
Before measuring, measure instruction unit 90 and start first measurement to illuminating circuit 64 instructions.Accept this instruction, illuminating circuit 64 is controlled as follows: some bright light source 104, and motor 110 is carried out to the driving of ormal weight.Its result configures selectively optical filter 106a in the light path of the light source 104 of lighting.
So the radiating light E radiating from light source 104 is through the optical filter 106a of radioactive department 102 and the base end side of optically focused parts 112 guiding fiber bundle 38b.Then, radiating light E penetrates by the inside of each optical fiber 38 and from the tip side of each optical fiber 38, projects to tympanum 32.Below, similarly, reflected light R receives light by light accepting part 42.
Below, step S2, S3 are also similarly carried out with step S1.Here, the second light splitting radioactive nature of step S2 is equivalent to be multiplied by the light splitting radioactive nature of light source 104 characteristic that the bandpass characteristics of optical filter 106b forms.Here, the 3rd light splitting radioactive nature of step S3 is equivalent to be multiplied by the light splitting radioactive nature of light source 104 characteristic that the bandpass characteristics of optical filter 106c forms.
Like this, even if replace various light sources and adopt the structure by multiple optical filter, also can realize multiple light splitting radioactive nature, can obtain Fig. 2 with blood-glucose meter 10() the identical action effect of situation.
In addition, the present invention is not limited to above-mentioned embodiment, can in not departing from the scope of the present invention, freely carry out various changes, and this is self-evident.
In above-mentioned embodiment, be body fluid as measuring object, be illustrated as an example of blood example, still, not limited.For example, can be also lymph fluid, spinal fluid, saliva etc.
In addition, as the composition in body fluid, except glucose, glycolated hemoglobin (blood glucose value), can be also cholesterol, uric acid, creatinine, lactic acid, hemoglobin (occult blood), various ethanol class, various saccharide, range protein, various vitamins, containing the various inorganic ionss of sodium, contain PCB(Polychlorinated biphenyls), the environmental hormone of dioxin.In addition, as measurement result, be not only the amount of composition, also can obtain different from it or with the constitutive property of its merging.
In addition,, in above-mentioned embodiment and variation, the kind of the radiating light E that light splitting radioactive nature is different (, the kind of light source or the kind of optical filter) is three kinds, still, is not limited to this, can be also two kinds, can also be more than four kinds.
Claims (8)
1. a component measuring device (10,10A), is characterized in that having:
Radiation unit (36,102), this radiation unit (36,102) is radiated a kind of radiating light (E) in the multiple radiating light that light splitting radioactive nature is different selectively;
Light receiving unit (42), this light receiving unit (42) is accepted reflected light (R) and is obtained the detection signal of the light quantity that represents described reflected light (R), this reflected light (R) obtains the body surface that is projected detected body by the described radiating light (E) of described radiation unit (36,102) radiation, and this reflected light (R) is relevant to the composition in described detected body;
Concentration quantitative unit (84), this concentration quantitative unit (84) carrys out the concentration of quantitative described composition according to the multiple described detection signal obtaining respectively according to the kind of each described radiating light (E);
Measurement of bldy temperature unit (86), the body temperature of described detected body is measured in this measurement of bldy temperature unit (86); And
Concentration correction unit (88), this concentration correction unit (88) adopts the described body temperature of being measured by described measurement of bldy temperature unit (86), to being revised by the quantitative described concentration in described concentration quantitative unit (84).
2. component measuring device according to claim 1 (10,10A), is characterized in that,
Under the state that described measurement of bldy temperature unit (86) stops in the radiation of the described radiating light (E) being undertaken by described radiation unit (36,102), according to by described light receiving unit (42) receive from body temperature described in the photo measure of described detected body.
3. component measuring device according to claim 1 (10,10A), is characterized in that,
Described at least one in described multiple radiating light, to belong to point optical absorption characteristics of described composition be 0 or the wave-length coverage of negative value to the peak wavelength of the described light splitting radioactive nature of radiating light (E).
4. component measuring device according to claim 1 (10), is characterized in that,
Described radiation unit (36) is multiple light sources that described light splitting radioactive nature is different (44a, 44b, 44c), makes selectively a kind of light source igniting in described multiple light source (44a, 44b, 44c).
5. component measuring device according to claim 1 (10A), is characterized in that,
Described radiation unit (102) has the different multiple optical filter of bandpass characteristics (106a, 106b, 106c) and light source (104), configures selectively a kind of optical filter in described multiple optical filter (106a, 106b, 106c) in the light path of the described light source (104) of lighting.
6. component measuring device according to claim 1 (10,10A), is characterized in that,
Also have measuring tube (14), this measuring tube (14) comprises the cylindrical portion (22) from tip side to base end side enlarged diameter and the bellying (24) bloating to radial outside at the base end side of described cylindrical portion (22),
By described measuring tube (14), carry out the projection of described radiating light (E) and the reception of described reflected light (R).
7. a composition measurement method, is characterized in that, adopts the component measuring device described in any one in claim 1 to 6 (10,10A) to measure the composition in detected body.
8. composition measurement method according to claim 7, is characterized in that, as described composition, measures the blood glucose value below tympanum (32) or the tongue of described detected body.
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| CN108354614A (en) * | 2017-01-26 | 2018-08-03 | 李韦辰 | Blood sugar detecting method, blood sugar test bearing calibration and blood sugar detection apparatus |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108354614A (en) * | 2017-01-26 | 2018-08-03 | 李韦辰 | Blood sugar detecting method, blood sugar test bearing calibration and blood sugar detection apparatus |
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Application publication date: 20141126 |