CN104152921A - Method for improving medical titanium alloy blood compatibility - Google Patents
Method for improving medical titanium alloy blood compatibility Download PDFInfo
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- CN104152921A CN104152921A CN201410439790.3A CN201410439790A CN104152921A CN 104152921 A CN104152921 A CN 104152921A CN 201410439790 A CN201410439790 A CN 201410439790A CN 104152921 A CN104152921 A CN 104152921A
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Abstract
A method for improving medical titanium alloy blood compatibility comprises the steps of (1) performing pretreatment and oil removing on a titanium alloy surface, and performing polishing and mechanical polishing on SiC abrasive paper; (2) performing micro-arc oxidation treatment on the pretreated titanium alloy, and obtaining an even rough porous micro-nano surface; (3) placing the titanium alloy obtained after micro-arc oxidation treatment into perfluorosebacamidine zinc-based trichlorosilane solutions to be soaked for six hours to 24 hours, and performing surface finishing; (4) performing flushing, performing drying under the condition at the temperature of 50 DEG C to 70 DEG C, that is, obtaining a super-hydrophobic thin film on the titanium alloy surface, and improving the titanium alloy blood compatibility. The manufacturing method is simple, the production cost is low, the product quality is easy to control, the pollution to the environment does not exist, and the titanium alloy blood compatibility can be greatly improved.
Description
Technical field
The present invention relates to the preparation of medical titanium alloy surface super hydrophobic thin film, be specifically related to a kind of method that improves medical titanium alloy blood compatibility.
Background technology
The advantages such as titanium or titanium alloy has that proportion is little, satisfactory mechanical property, erosion resistance are strong, workability and biocompatibility excellence make it become one of most important bio-medical material.In recent years, titanium alloy material is used more and more in the research and development of the medical material directly contacting with blood of human body, such as: hemodialysis system, extracorporeal circulation system, intravascular stent, heart valve, ventricular assist device and conduit etc.When material directly contacts with blood, between blood and material, will produce a series of biological respinses.Material surface occurs that plasma proteins is adsorbed, platelet adhesion reaction, gathering, distortion etc., and finally form thrombus and blood coagulation occurs.Although titanium alloy has good blood compatibility, also inevitably there will be blood coagulation problem, so at present titanium alloy is carried out to surface modification, further to improve its blood compatibility be one of study hotspot of medical titanium alloy.At present, be applied to titanium alloy surface method of modifying a lot, as thermal oxidation method, sol-gel, differential arc oxidation, anodic oxidation, biomimetic method, magnetron sputtering, plasma body soak ion implantation and deposition, spraying method etc.For improving blood compatibility, the film forming at titanium alloy surface mainly contains hydroxyapatite, titanium dioxide, titanium nitride, DLC, RESEARCH OF PYROCARBON, aluminum oxide etc.Although these research work have all obtained progress, in clinical application, still could not solve the blood coagulation problem of titanium alloy completely.
Summary of the invention
The object of the present invention is to provide a kind of method that improves medical titanium alloy blood compatibility, solved the blood coagulation problem of titanium alloy.
The present invention is achieved like this, and it is characterized in that method steps is:
(1) titanium alloy surface pre-treatment, deoils, SiC sand papering and mechanical polishing;
(2) pretreated titanium alloy is carried out to differential arc oxidation processing, obtain uniform rough porous micro-nano surface;
(3) again sample is placed in to perfluor zinc-base trichlorosilane solution soaking 6 ~ 24h, carries out finishing;
(4) rinse, under 50 ~ 70 ℃ of conditions, dry, at titanium alloy surface, obtain super-hydrophobic coat, improve the blood compatibility of titanium alloy.
Described titanium alloy can be pure titanium, Ti-6Al-4V alloy, Ti-6Al-7Nb alloy and NiTi alloy.
Described perfluor zinc-base trichlorosilane solution is perfluor zinc-base trichlorosilane ethanol solution.
The present invention can form super-hydrophobic coating of titanium dioxide on biological medical titanium alloy surface, and its surface micropore diameter is that 100nm-contact angle can reach 150 ~ 160, and hemolysis rate is 0.1 ~ 1%, and in platelet adhesion test, specimen surface is almost without platelet adhesion reaction.
Technique effect of the present invention is: preparation method of the present invention is simple, and production cost is low, and quality product is easy to control, and environmentally safe can improve the blood compatibility of titanium alloy very effectively, solves blood coagulation problem.
Accompanying drawing explanation
The surperficial SEM photo of Fig. 1 is embodiment 1 acquisition sample.
The contact angle photo of Fig. 2 is embodiment 1 acquisition sample.
Embodiment
Below in conjunction with drawings and Examples, the present invention is further elaborated.
Embodiment 1
(1) Ti-6Al-4V alloy surface pre-treatment, deoils, SiC sand papering and mechanical polishing;
(2) pretreated Ti-6Al-4V alloy is put into 10g/L trisodium phosphate aqueous solution and carry out differential arc oxidation processing, processing voltage is 400V, and the treatment time is 10min;
(3) again sample is placed in to perfluor zinc-base trichlorosilane ethanol solution and soaks 12h;
(4) rinse, under 50 ℃ of conditions, dry, at Ti-6Al-4V alloy surface, obtain super-hydrophobic coat, improve the blood compatibility of Ti-6Al-4V alloy.
The present invention can form super-hydrophobic coating of titanium dioxide at bio-medical Ti-6Al-4V alloy surface, and its surface micropore diameter is 200 ~ 1000nm, and contact angle can reach 153, and hemolysis rate is 0.4%, and in platelet adhesion test, specimen surface is almost without platelet adhesion reaction.
embodiment 2
(1) NiTi alloy surface pre-treatment, deoils, SiC sand papering and mechanical polishing;
(2) pretreated NiTi alloy is put into 12g/L sodium aluminate+1g/L ortho phosphorous acid sodium water solution and carried out differential arc oxidation processing, processing voltage is 400V, and the treatment time is 10min;
(3) again sample is placed in to perfluor zinc-base trichlorosilane ethanol solution and soaks 18h;
(4) rinse, under 60 ℃ of conditions, dry, on NiTi surface, obtain super-hydrophobic coat, improve the blood compatibility of NiTi alloy.
The present invention can form super-hydrophobic alumina coating on biological medical NiTi surface, and its surface micropore diameter is 500 ~ 1500nm, and contact angle can reach 157, and hemolysis rate is 0.3%, and in platelet adhesion test, specimen surface is almost without platelet adhesion reaction.
embodiment 3
(1) Ti-6Al-7Nb alloy surface pre-treatment, deoils, SiC sand papering and mechanical polishing;
(2) pretreated NiTi alloy is put into 30mL/L phosphate aqueous solution and carry out differential arc oxidation processing, processing voltage is 400V, and the treatment time is 10min;
(3) again sample is placed in to perfluor zinc-base trichlorosilane ethanol solution and soaks 6h;
(4) rinse, under 70 ℃ of conditions, dry, at Ti-6Al-7Nb alloy surface, obtain super-hydrophobic coat, improve the blood compatibility of Ti-6Al-7Nb alloy.
The present invention can form super-hydrophobic coating of titanium dioxide at bio-medical Ti-6Al-7Nb alloy surface, and its surface micropore diameter is 100 ~ 1000nm, and contact angle can reach 155, and hemolysis rate is 0.5%, and in platelet adhesion test, specimen surface is almost without platelet adhesion reaction.
Claims (3)
1. a method that improves medical titanium alloy blood compatibility, is characterized in that, described preparation method comprises the following steps:
(1) titanium alloy surface pre-treatment, deoils, SiC sand papering and mechanical polishing;
(2) pretreated titanium alloy is carried out to differential arc oxidation processing, obtain uniform rough porous micro-nano surface;
(3) again sample is placed in to perfluor zinc-base trichlorosilane solution soaking 6 ~ 24h, carries out finishing;
(4) rinse, under 50 ~ 70 ℃ of conditions, dry, at titanium alloy surface, obtain based superhydrophobic thin films, improve the blood compatibility of titanium alloy.
2. a kind of method that improves medical titanium alloy blood compatibility according to claim 1, is characterized in that: described titanium alloy can be pure titanium, Ti-6Al-4V alloy, Ti-6Al-7Nb alloy and NiTi alloy.
3. a kind of method that improves medical titanium alloy blood compatibility according to claim 1, is characterized in that: described perfluor zinc-base trichlorosilane solution is perfluor zinc-base trichlorosilane ethanol solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410439790.3A CN104152921B (en) | 2014-09-02 | 2014-09-02 | A kind of method improving medical titanium alloy blood compatibility |
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| CN201410439790.3A CN104152921B (en) | 2014-09-02 | 2014-09-02 | A kind of method improving medical titanium alloy blood compatibility |
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| CN104152921A true CN104152921A (en) | 2014-11-19 |
| CN104152921B CN104152921B (en) | 2016-11-16 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111893542A (en) * | 2020-08-06 | 2020-11-06 | 嵊州市森拓新材料有限公司 | Titanium alloy of super-hydrophobic micro-arc oxidation wear-resistant coating and preparation method thereof |
| CN113368315A (en) * | 2021-06-09 | 2021-09-10 | 河北工业大学 | Medical nickel-titanium alloy material with temperature-sensitive hydrogel coating and preparation method and application thereof |
| CN115444982A (en) * | 2022-10-31 | 2022-12-09 | 安徽医科大学 | Super-hydrophobic self-cleaning anticoagulation composite coating material and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102618913A (en) * | 2012-04-10 | 2012-08-01 | 大连理工大学 | Method for preparing titanium or titanium alloy super-hydrophobic surface |
| CN103212528A (en) * | 2013-04-22 | 2013-07-24 | 华南理工大学 | Preparation method for metallic titanium surface super-hydrophobic thin film |
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2014
- 2014-09-02 CN CN201410439790.3A patent/CN104152921B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102618913A (en) * | 2012-04-10 | 2012-08-01 | 大连理工大学 | Method for preparing titanium or titanium alloy super-hydrophobic surface |
| CN103212528A (en) * | 2013-04-22 | 2013-07-24 | 华南理工大学 | Preparation method for metallic titanium surface super-hydrophobic thin film |
Non-Patent Citations (3)
| Title |
|---|
| TAOLEI SUN ET AL.: "No Platelet Can Adhere-Largely Improved Blood Compatibility on Nanostructrued Superhydrophobic Surfaces", 《SMALL》, vol. 1, no. 10, 1 August 2005 (2005-08-01), pages 959 - 963 * |
| 朱立群: "《功能膜层的电沉积理论与技术》", 31 May 2005 * |
| 杨云等: "TiO2纳米管薄膜超亲水-超疏水表面血液相容性研究", 《第十四次全国电化学会议论文汇编》, 11 August 2008 (2008-08-11), pages 457 - 459 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111893542A (en) * | 2020-08-06 | 2020-11-06 | 嵊州市森拓新材料有限公司 | Titanium alloy of super-hydrophobic micro-arc oxidation wear-resistant coating and preparation method thereof |
| CN111893542B (en) * | 2020-08-06 | 2021-08-03 | 牡丹江申佳合金材料有限公司 | Titanium alloy of super-hydrophobic micro-arc oxidation wear-resistant coating and preparation method thereof |
| CN113368315A (en) * | 2021-06-09 | 2021-09-10 | 河北工业大学 | Medical nickel-titanium alloy material with temperature-sensitive hydrogel coating and preparation method and application thereof |
| CN113368315B (en) * | 2021-06-09 | 2022-04-19 | 河北工业大学 | Medical nickel-titanium alloy material with temperature-sensitive hydrogel coating and preparation method and application thereof |
| CN115444982A (en) * | 2022-10-31 | 2022-12-09 | 安徽医科大学 | Super-hydrophobic self-cleaning anticoagulation composite coating material and preparation method and application thereof |
| WO2024092856A1 (en) * | 2022-10-31 | 2024-05-10 | 安徽医科大学 | Super-hydrophobic self-cleaning anticoagulant composite coating material, method for preparing same, and use thereof |
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| CN104152921B (en) | 2016-11-16 |
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