CN104138333A - Double-layer polyethylene liquid medicinal bottle and preparation method for same - Google Patents
Double-layer polyethylene liquid medicinal bottle and preparation method for same Download PDFInfo
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- CN104138333A CN104138333A CN201310169406.8A CN201310169406A CN104138333A CN 104138333 A CN104138333 A CN 104138333A CN 201310169406 A CN201310169406 A CN 201310169406A CN 104138333 A CN104138333 A CN 104138333A
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Abstract
The invention relates to a double-layer polyethylene liquid medicinal bottle and a preparation method for the same, which belong to the technical field of medicinal plastic bottle processing. The liquid medicinal bottle is composed of an inner layer and an outer layer, wherein the inner layer is made from high-density polyethylene; the outer layer is prepared from the following constituents in percentage by weight: 68-88% of high-density polyethylene, 0.2-3% of antioxidant 264, 0.05-2% of antioxidant CA and 10-30% of aluminium hydroxide. The liquid medicinal bottle disclosed by the invention has the advantages of being good in flame retardance, gas barrier property and impact-resistance strength, thus being capable of meeting the needs of storage and transport for a liquid medicament, and capable of ensuring the quality of the liquid medicament.
Description
Technical field
The invention belongs to plastic drug package processing technique field, be specifically related to a kind of double-layer polyethylene liquid, medicinal bottle and preparation method thereof.
Background technology
At present, the pharmaceutical pack of liquid preparation adopts vial mostly, exists following shortcoming: (1) vial is more crisp, easily broken, can not push, and makes troubles to production and transport; (2) before liquid preparation fill, need to clean, dry and disinfect, increase production cost, also increase production management and the quality management requirement of pharmaceutical producing enterprise; (3), due to frangible,, there is potential safety hazard in easy Fire explosion in storage and transportation.The employing plastic bottle separately having is packed, but anti-flammability, barrier properties for gases and impact strength are poor, can not meet the demand that now liquid preparation is stored and transported.
Summary of the invention
The object of this invention is to provide a kind of double-layer polyethylene liquid, medicinal bottle with good flame-retardance, barrier properties for gases and impact strength.
Another object of the present invention is to provide the preparation method of this double-layer polyethylene liquid, medicinal bottle.
The technical solution used in the present invention is a kind of double-layer polyethylene liquid, medicinal bottle, described liquid, medicinal bottle is made up of internal layer and skin, described internal layer is made up of high density polyethylene (HDPE), and described skin is made up of the component of following weight percentage ratio: 68%～88% high density polyethylene (HDPE), 0.2%～3% antioxidant 264,0.05%～2% antioxidant CA and 10%～30% aluminium hydroxide.
As preferably, described skin is made up of the component of following weight percentage ratio: 72%～84% high density polyethylene (HDPE), 0.5%～2.5% antioxidant 264,0.1%～1% antioxidant CA and 15%～25% aluminium hydroxide.
As preferably, described skin is made up of the component of following weight percentage ratio: 77.7% high density polyethylene (HDPE), 1.8% antioxidant 264,0.5% antioxidant CA and 20% aluminium hydroxide.
As preferably, described internal layer and outer field Thickness Ratio are 1:1.
As preferably, described internal layer and outer field Thickness Ratio are 2:1.
Double-layer polyethylene liquid, medicinal bottle of the present invention can adopt conventional preparation method to prepare.And above-mentioned each component is made to the preferred preparation method of double-layer polyethylene liquid, medicinal bottle of the present invention, comprise the following steps:
A, by after above-specified high density polyethylene, antioxidant 264, antioxidant CA and aluminium hydroxide mix homogeneously, pelletize, obtains modified particles;
B, utilize double-layer coextrusion extrusion-blown modling equipment using modified particles as cladding material, described high density polyethylene (HDPE) is as inner layer material, inside and outside materials at two layers is mixed into tubulose melt in this equipment extrusion neck ring mold, and tubulose melt, after blow mold stretch-blow is cooling, obtains finished product.
The time of mixing in described step a further, is 20～30 minutes.
Beneficial effect of the present invention is:
(1) compared with glass liquid, medicinal bottle processed, be difficult for fragmentation, lightweight, convenient production and transport; Before filling liquid medicament, without processing technique such as cleanings, can carry out better Quality Control, saved the operation costs of production and manufacturing enterprise simultaneously;
(2) the present invention has good anti-flammability, in storage and transportation, is difficult for Fire explosion;
(3) the present invention has stronger impact strength, in the time of transport, and can prevent to collide time, can be not broken, thus avoid potential safety hazard and waste medicament;
(4) the present invention has good barrier properties for gases, the 1/3-1/5 that is pure high-density polyethylene bottle to gas permeation rates such as water vapour, oxygen, carbon dioxide, thus can effectively ensure the quality of volatile liquid medicament and avoid ambient atmos to invade in medicament.
Detailed description of the invention
For making those skilled in the art understand in detail production technology of the present invention and technique effect, further introduce application of the present invention and technique effect with concrete production instance below.
Embodiment mono-:
Take by weight percentage 77.7% high density polyethylene (HDPE), 1.8% antioxidant 264,0.5% antioxidant CA and 20% aluminium hydroxide mix 20 minutes evenly after, pelletize, obtains modified particles; Utilize double-layer coextrusion extrusion-blown modling equipment using modified particles as cladding material, high density polyethylene (HDPE) is as inner layer material, inside and outside materials at two layers is mixed into tubulose melt in this equipment extrusion neck ring mold, and tubulose melt, after blow mold stretch-blow is cooling, obtains finished product.Wherein, internal layer and outer field Thickness Ratio are 1:1.Anti-flammability test is tested by UL-94 standard, is V1; Barrier properties for gases is tested by GB/T1038-2000, is pure high-density polyethylene bottle 1/3 to water vapour, oxygen, carbon dioxide transmitance; Cantilever notched Izod impact strength is tested by ASTM D-256 standard, is 63J/M.
Embodiment bis-:
Take by weight percentage 72% high density polyethylene (HDPE), 2% antioxidant 264,1% antioxidant CA and 25% aluminium hydroxide mix 30 minutes evenly after, pelletize, obtains modified particles; Utilize double-layer coextrusion extrusion-blown modling equipment using modified particles as cladding material, high density polyethylene (HDPE) is as inner layer material, inside and outside materials at two layers is mixed into tubulose melt in this equipment extrusion neck ring mold, and tubulose melt, after blow mold stretch-blow is cooling, obtains finished product.Wherein, internal layer and outer field Thickness Ratio are 2:1.Anti-flammability test is tested by UL-94 standard, is V1; Barrier properties for gases is tested by GB/T1038-2000, is pure high-density polyethylene bottle 1/5 to water vapour, oxygen, carbon dioxide transmitance; Cantilever notched Izod impact strength is tested by ASTM D-256 standard, is 65J/M.
Embodiment tri-:
Take by weight percentage 84% high density polyethylene (HDPE), 0.8% antioxidant 264,0.2% antioxidant CA and 15% aluminium hydroxide mix 30 minutes evenly after, pelletize, obtains modified particles; Utilize double-layer coextrusion extrusion-blown modling equipment using modified particles as cladding material, high density polyethylene (HDPE) is as inner layer material, inside and outside materials at two layers is mixed into tubulose melt in this equipment extrusion neck ring mold, and tubulose melt, after blow mold stretch-blow is cooling, obtains finished product.Wherein, internal layer and outer field Thickness Ratio are 2:1.Anti-flammability test is tested by UL-94 standard, is V1; Barrier properties for gases is tested by GB/T1038-2000, is pure high-density polyethylene bottle 1/4 to water vapour, oxygen, carbon dioxide transmitance; Cantilever notched Izod impact strength is tested by ASTM D-256 standard, is 61J/M.
Embodiment tetra-:
Take by weight percentage 80% high density polyethylene (HDPE), 1.6% antioxidant 264,0.4% antioxidant CA and 18% aluminium hydroxide mix 25 minutes evenly after, pelletize, obtains modified particles; Utilize double-layer coextrusion extrusion-blown modling equipment using modified particles as cladding material, high density polyethylene (HDPE) is as inner layer material, inside and outside materials at two layers is mixed into tubulose melt in this equipment extrusion neck ring mold, and tubulose melt, after blow mold stretch-blow is cooling, obtains finished product.Wherein, internal layer and outer field Thickness Ratio are 2:1.Anti-flammability test is tested by UL-94 standard, is V1; Barrier properties for gases is tested by GB/T1038-2000, is pure high-density polyethylene bottle 1/3 to water vapour, oxygen, carbon dioxide transmitance; Cantilever notched Izod impact strength is tested by ASTM D-256 standard, is 64J/M.
The technical scheme above embodiment of the present invention being provided is described in detail, applied principle and the embodiment of specific case to the embodiment of the present invention herein and set forth, the explanation of above embodiment is only applicable to help to understand the principle of the embodiment of the present invention; , for one of ordinary skill in the art, according to the embodiment of the present invention, in detailed description of the invention and range of application, all will change, in sum, this description should not be construed as limitation of the present invention meanwhile.
Claims (7)
1. a double-layer polyethylene liquid, medicinal bottle, it is characterized in that: described liquid, medicinal bottle is made up of internal layer and skin, described internal layer is made up of high density polyethylene (HDPE), and described skin is made up of the component of following weight percentage ratio: 68%～88% high density polyethylene (HDPE), 0.2%～3% antioxidant 264,0.05%～2% antioxidant CA and 10%～30% aluminium hydroxide.
2. a kind of double-layer polyethylene liquid, medicinal bottle according to claim 1, is characterized in that: described skin is made up of the component of following weight percentage ratio: 72%～84% high density polyethylene (HDPE), 0.5%～2.5% antioxidant 264,0.1%～1% antioxidant CA and 15%～25% aluminium hydroxide.
3. a kind of double-layer polyethylene liquid, medicinal bottle according to claim 1, is characterized in that: described skin is made up of the component of following weight percentage ratio: 77.7% high density polyethylene (HDPE), 1.8% antioxidant 264,0.5% antioxidant CA and 20% aluminium hydroxide.
4. a kind of double-layer polyethylene liquid, medicinal bottle according to claim 1, is characterized in that: described internal layer and outer field Thickness Ratio are 1:1.
5. a kind of double-layer polyethylene liquid, medicinal bottle according to claim 1, is characterized in that: described internal layer and outer field Thickness Ratio are 2:1.
6. the preparation method based on a kind of double-layer polyethylene liquid, medicinal bottle described in any one in claim 1-3, is characterized in that: comprise the following steps:
A, by after above-specified high density polyethylene, antioxidant 264, antioxidant CA and aluminium hydroxide mix homogeneously, pelletize, obtains modified particles;
B, utilize double-layer coextrusion extrusion-blown modling equipment using modified particles as cladding material, described high density polyethylene (HDPE) is as inner layer material, inside and outside materials at two layers is mixed into tubulose melt in this equipment extrusion neck ring mold, and tubulose melt, after blow mold stretch-blow is cooling, obtains finished product.
7. the preparation method of a kind of double-layer polyethylene liquid, medicinal bottle according to claim 6, is characterized in that: the time of mixing in described step a is 20～30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310169406.8A CN104138333A (en) | 2013-05-09 | 2013-05-09 | Double-layer polyethylene liquid medicinal bottle and preparation method for same |
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| CN201310169406.8A CN104138333A (en) | 2013-05-09 | 2013-05-09 | Double-layer polyethylene liquid medicinal bottle and preparation method for same |
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| CN104138333A true CN104138333A (en) | 2014-11-12 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106009145A (en) * | 2016-05-17 | 2016-10-12 | 安徽丰华医药包装有限公司 | Production technology of HDPE (high-density polyethylene) bottles for oral solid drugs |
| CN107118419A (en) * | 2017-06-05 | 2017-09-01 | 广州市永乐塑料制品有限公司 | A kind of production method of medicinal polyethylene bottle |
| CN108403426A (en) * | 2018-02-23 | 2018-08-17 | 浙江济民制药股份有限公司 | The special dry powder bag of the online B dry powder of haemodialysis |
| CN110964252A (en) * | 2019-12-18 | 2020-04-07 | 苏州洁之宝塑料制品有限公司 | Medicine storage bottle and preparation method thereof |
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| CN1465616A (en) * | 2002-06-21 | 2004-01-07 | 中国科学院化学研究所 | Magnetsium hydroxide halogen-free polythene flame redardant composite material |
| CN1746081A (en) * | 2004-09-06 | 2006-03-15 | 上海紫华容器包装有限公司 | Antibacterial packing plastic bottle |
| CN1820034A (en) * | 2002-10-15 | 2006-08-16 | 埃克森美孚化学专利公司 | Polyolefin adhesive compositions and articles made therefrom |
| CN101148526A (en) * | 2007-09-04 | 2008-03-26 | 华南理工大学 | Metal hydroxide halogen-free anti-flaming polyolefin composition and preparation method thereof |
| KR100889220B1 (en) * | 2007-12-12 | 2009-03-17 | 삼성토탈 주식회사 | High density polyethylene resin composition for chemical bottle |
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2013
- 2013-05-09 CN CN201310169406.8A patent/CN104138333A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1465616A (en) * | 2002-06-21 | 2004-01-07 | 中国科学院化学研究所 | Magnetsium hydroxide halogen-free polythene flame redardant composite material |
| CN1820034A (en) * | 2002-10-15 | 2006-08-16 | 埃克森美孚化学专利公司 | Polyolefin adhesive compositions and articles made therefrom |
| CN1746081A (en) * | 2004-09-06 | 2006-03-15 | 上海紫华容器包装有限公司 | Antibacterial packing plastic bottle |
| CN101148526A (en) * | 2007-09-04 | 2008-03-26 | 华南理工大学 | Metal hydroxide halogen-free anti-flaming polyolefin composition and preparation method thereof |
| KR100889220B1 (en) * | 2007-12-12 | 2009-03-17 | 삼성토탈 주식회사 | High density polyethylene resin composition for chemical bottle |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106009145A (en) * | 2016-05-17 | 2016-10-12 | 安徽丰华医药包装有限公司 | Production technology of HDPE (high-density polyethylene) bottles for oral solid drugs |
| CN107118419A (en) * | 2017-06-05 | 2017-09-01 | 广州市永乐塑料制品有限公司 | A kind of production method of medicinal polyethylene bottle |
| CN108403426A (en) * | 2018-02-23 | 2018-08-17 | 浙江济民制药股份有限公司 | The special dry powder bag of the online B dry powder of haemodialysis |
| CN110964252A (en) * | 2019-12-18 | 2020-04-07 | 苏州洁之宝塑料制品有限公司 | Medicine storage bottle and preparation method thereof |
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Application publication date: 20141112 |
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