CN104112023A - Computer database system based paternity identification search method - Google Patents
Computer database system based paternity identification search method Download PDFInfo
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- CN104112023A CN104112023A CN201410368913.9A CN201410368913A CN104112023A CN 104112023 A CN104112023 A CN 104112023A CN 201410368913 A CN201410368913 A CN 201410368913A CN 104112023 A CN104112023 A CN 104112023A
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Abstract
The invention discloses a computer database system based paternity identification search method. The method includes the steps: A, importing data samples by the aid of genemapper software; B, performing XY/XX reading of all the samples in a computer database system and dividing the samples into male samples and female samples; C, respectively performing diad search on designated filial samples and the male samples and the female samples in the computer database system, screening out assumed fathers and assumed mothers satisfying diad paternity relations and performing diad paternity calculation, so that suspected fathers and suspected mothers are obtained; D, calculating biological parents satisfying triad paternity relations with the designated filial samples by the aid of the suspected fathers, the suspected mothers and the designated filial samples according to a triad calculating method. The computer database system based paternity identification search method has the advantages that the parents satisfying paternity relations can be found out conveniently, sample capacity of false positive caused by single parent search is decreased, and paternity judgment accuracy and paternity judgment reliability are improved.
Description
Technical field
The present invention relates to medicolegal genetics technical field, particularly a kind of method of utilizing Computer Database to retrieve the triplet sample in paternity identification process.
Background technology
Paternity identification refers to by the detection to human inheritance's mark, according to Inheritance Analysis on Genetic, judges between father and mother and child whether be one's own relation.Paternity identification is generally divided into dyad paternity identification and triplet paternity identification, dyad paternity identification refers to the parent child relationship qualification between detected man and child, and triplet paternity identification refers to the parent child relationship qualification between detected man, child breeder mother and child.
In recent years, along with popularizing of computing machine, computer database system has all been set up in the police and local large-scale DNA forensic laboratory, for the data storage of sample and the retrieval of individual identification and paternity identification, therefore computer database system be based upon find abducted children and search the effect of crime one's share of expenses for a joint undertaking aspect performance increasing.But, because Chinese population radix is large, and the forensic initial stage is used DNA locus negligible amounts used when detecting, and the kit that different laboratories is selected is inconsistent, this just cause except national regulation must examine locus also exist different locus.In the time storing a large amount of sample DNA data in computer database system, while utilizing father or mother's data to retrieve, there will be dozens of or tens samples all to meet the situation of mendel's law.Computing machine just cannot effectively be judged the relation of parental generation and filial generation in this case, needs manual intervention to confirm.Now, just need laboratory to increase the detection locus of sample that is retrieved, or add breeder mother or father's sample, manually carry out triplet calculating, get rid of false positive sample; Not only increase cost, and complex operation, large, the consuming time length of workload and easily make mistakes.
Summary of the invention
The technical issues that need to address of the present invention are to provide the method for triplet sample searching in a kind of paternity identification based on computer database system, thereby conveniently find out the father and mother that meet parental right relation, reduce single parent and retrieve false-positive sample size, improve parental right and judge accuracy and reliability.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows.
Paternity identification search method based on computer database system, comprises the following steps:
A. import filial generation sample and the data sample relevant to the filial generation sample of specifying of specifying by genemapper software;
B. all samples in computer database system are carried out to XY/XX and read, sample is divided into male sex's sample and women's sample;
C. by the filial generation sample of appointment respectively with computer database system in male sex's sample and women's sample carry out dyad retrieval, filter out m the supposition father and n the supposition mother that meet dyad parental right relation; Appointment filial generation sample is carried out to the calculating of dyad parental right with m supposition father and n supposition mother respectively, obtain m1 doubtful father and n1 doubtful mother; Wherein m1 < m, n1 < n;
D. m1 doubtful father, a n1 doubtful mother and appointment filial generation sample are calculated with specifying filial generation sample and meet biology father, the mother of triplet parental right relation according to triplet computing method.
Dyad computing method described in step C of the present invention are: calculate respectively and specify filial generation sample and each supposition paternity index value of father and each supposition mother's paternity index value according to the gene frequency of setting in dyad paternity index computing formula and computer database system, finally filter out respectively the doubtful father and the doubtful mother that meet genetic development; Described dyad paternity index computing formula is:
Triplet computing method described in step D of the present invention are: the doubtful father who meets genetic development who obtains according to step C, doubtful mother and appointment filial generation sample calculate according to triplet parental right computing formula, and the paternity index value that integrating step C obtains filters out the biological parenthood that meets law of inheritance; Described triplet parental right computing formula is:
Owing to having adopted above technical scheme, the invention technological progress is as follows.
Before the invention solves, computational data storehouse system can only be searched doubtful dyad by single parent, in mass data situation, easily occurs false-positive situation; Overcome the problem of manually searching the inefficiency of existence, can conveniently find out the father and mother that meet parental right relation, reduced single parent and retrieve false-positive sample size, improved parental right and judge accuracy and reliability.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Paternity identification search method based on computer database system, comprises the following steps:
A. by genemapper software import specify filial generation sample and to specify filial generation sample relevant data sample.In the present embodiment, import altogether 21 sample datas, data from the close sample of parental right relation in paternity identification laboratory data base, wherein the filial generation sample of sample 1 for specifying need to find its biological parenthood in computer database system.
B. the sample in computer database system is read according to sex site XX/XY, sample is divided into male sex's sample and women's sample.In the present embodiment, remaining 20 samples are divided into 10 male sex's samples and 10 women's samples after reading according to sex site XX/XY, Genemapper software import process in using these 20 sample link to computer database system in as the father and mother's sample being retrieved.
C. by the filial generation sample of appointment respectively with computer database system in male sex's sample and women's sample carry out dyad retrieval, filter out m the supposition father and n the supposition mother that meet dyad parental right relation; Appointment filial generation sample is carried out to the calculating of dyad parental right with m supposition father and n supposition mother respectively, obtain m1 doubtful father and n1 doubtful mother; Wherein m1 < m, n1 < n.
The method of dyad retrieval is: calculate respectively and specify filial generation sample and each supposition paternity index value of father and each supposition mother's paternity index value according to the gene frequency of setting in dyad paternity index computing formula and computer database system, finally filter out respectively the doubtful father and the doubtful mother that meet genetic development; Described dyad paternity index computing formula is:
In the present embodiment, calculate result that rear acquisition meets paternity identification technical manual standard as following table according to dyad paternity index computing formula.
D. m1 doubtful father, a n1 doubtful mother and appointment filial generation sample are calculated with specifying filial generation sample and meet biology father, the mother of triplet parental right relation according to triplet computing method.
Triplet computing method are: the doubtful father who meets genetic development who obtains according to step C, doubtful mother and appointment filial generation sample calculate according to triplet parental right computing formula, and the paternity index value that integrating step C obtains filters out the biological parenthood that meets law of inheritance; Described triplet parental right computing formula is:
Result of determination is as shown in the table:
Certainly, the present invention can also carry out according to the sample of specifying father and mother the paternity identification of filial generation, in this process, after can first screening according to the male sex, women, sample age bracket and sample region in computer database system, carry out again the calculating of triplet parental right, obtain possible filial generation in computer database system.
Claims (3)
1. the paternity identification search method based on computer database system, is characterized in that comprising the following steps:
A. import filial generation sample and the data sample relevant to the filial generation sample of specifying of specifying by genemapper software;
B. all samples in computer database system are carried out to XY/XX and read, sample is divided into male sex's sample and women's sample;
C. by the filial generation sample of appointment respectively with computer database system in male sex's sample and women's sample carry out dyad retrieval, filter out m the supposition father and n the supposition mother that meet dyad parental right relation; Appointment filial generation sample is carried out to the calculating of dyad parental right with m supposition father and n supposition mother respectively, obtain m1 doubtful father and n1 doubtful mother; Wherein m1 < m, n1 < n;
D. m1 doubtful father, a n1 doubtful mother and appointment filial generation sample are calculated with specifying filial generation sample and meet biology father, the mother of triplet parental right relation according to triplet computing method.
2. the paternity identification search method based on computer database system according to claim 1, it is characterized in that the dyad computing method described in step C are: calculate respectively and specify filial generation sample and each supposition paternity index value of father and each supposition mother's paternity index value according to the gene frequency of setting in dyad paternity index computing formula and computer database system, finally filter out respectively the doubtful father and the doubtful mother that meet genetic development; Described dyad paternity index computing formula is:
。
3. the paternity identification search method based on computer database system according to claim 1, it is characterized in that the triplet computing method described in step D are: the doubtful father who meets genetic development who obtains according to step C, doubtful mother and appointment filial generation sample calculate according to triplet parental right computing formula, and the paternity index value that integrating step C obtains filters out the biological parenthood that meets law of inheritance; Described triplet parental right computing formula is:
。
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104480205A (en) * | 2014-12-10 | 2015-04-01 | 西安交通大学 | Method of establishing animal paternity identification system on basis of whole genome STR |
| CN107748837A (en) * | 2017-09-18 | 2018-03-02 | 安徽工程大学 | A kind of computational methods of the DNA identification paternity indexs comprising gene mutation |
| CN115206425A (en) * | 2022-08-24 | 2022-10-18 | 温州医科大学 | Triplet paternity testing method, system, equipment and storage medium |
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| US20110276525A1 (en) * | 2004-12-23 | 2011-11-10 | Greg Hampikian | Reference markers for biological samples |
| CN101838686A (en) * | 2009-12-16 | 2010-09-22 | 公安部物证鉴定中心 | Genetic relationship identification device and method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104480205A (en) * | 2014-12-10 | 2015-04-01 | 西安交通大学 | Method of establishing animal paternity identification system on basis of whole genome STR |
| CN107748837A (en) * | 2017-09-18 | 2018-03-02 | 安徽工程大学 | A kind of computational methods of the DNA identification paternity indexs comprising gene mutation |
| CN107748837B (en) * | 2017-09-18 | 2021-05-04 | 安徽工程大学 | Method for calculating DNA identification paternity index containing gene mutation |
| CN115206425A (en) * | 2022-08-24 | 2022-10-18 | 温州医科大学 | Triplet paternity testing method, system, equipment and storage medium |
| CN115206425B (en) * | 2022-08-24 | 2023-03-21 | 温州医科大学 | Triplet paternity testing method, system, equipment and storage medium |
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