CN104090008A - Preparation method of electrochemical sensor based on mesoporous silica modified electrode - Google Patents
Preparation method of electrochemical sensor based on mesoporous silica modified electrode Download PDFInfo
- Publication number
- CN104090008A CN104090008A CN201410367527.8A CN201410367527A CN104090008A CN 104090008 A CN104090008 A CN 104090008A CN 201410367527 A CN201410367527 A CN 201410367527A CN 104090008 A CN104090008 A CN 104090008A
- Authority
- CN
- China
- Prior art keywords
- mcm
- preparation
- hydroxylamine solution
- electrochemical sensor
- fecl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims description 19
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims description 14
- 239000000377 silicon dioxide Substances 0.000 title description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 30
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 24
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims description 21
- 239000002122 magnetic nanoparticle Substances 0.000 claims description 16
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 12
- 239000000725 suspension Substances 0.000 claims description 12
- METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 claims description 11
- IYIKLHRQXLHMJQ-UHFFFAOYSA-N amiodarone Chemical compound CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCCN(CC)CC)C(I)=C1 IYIKLHRQXLHMJQ-UHFFFAOYSA-N 0.000 claims description 11
- 229960005260 amiodarone Drugs 0.000 claims description 11
- 229960002274 atenolol Drugs 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000012153 distilled water Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000004115 Sodium Silicate Substances 0.000 claims description 6
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 6
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 239000000428 dust Substances 0.000 claims description 4
- 239000002480 mineral oil Substances 0.000 claims description 4
- 235000010446 mineral oil Nutrition 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 claims description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
- 239000012298 atmosphere Substances 0.000 claims description 3
- 238000001354 calcination Methods 0.000 claims description 3
- 229910052802 copper Inorganic materials 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000004570 mortar (masonry) Substances 0.000 claims description 3
- 229910052814 silicon oxide Inorganic materials 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 229920002994 synthetic fiber Polymers 0.000 claims description 2
- 238000003801 milling Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 description 8
- 238000001514 detection method Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000002808 molecular sieve Substances 0.000 description 4
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 4
- 239000011148 porous material Substances 0.000 description 3
- 239000002327 cardiovascular agent Substances 0.000 description 2
- 229940125692 cardiovascular agent Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- -1 aminopropyl Chemical group 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 239000013335 mesoporous material Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
Landscapes
- Silicates, Zeolites, And Molecular Sieves (AREA)
Abstract
The invention relates to a novel electrochemical sensor which comprises a magnetic electrode and is suitable for simultaneously detecting amiodarone (AM) and atenolol (AT). According to the novel electrochemical sensor, functionalized ammonia propyl is fixed to the surface of MCM-41 silica through reflux reaction between MCM-41 and 3-ammonia propyl triethoxysilane in methylbenzene; mesoporous silica is integrated with magnetic nanoparticles to form a porous magnetic nanocomposite electrode-MCM-41-nPrNH2; MCM-41-nPrNH2 loaded with Fe2O3 can enhance anode current by absorbing amiodarone and atenolol on the surface of the electrode; the MCM-41-nPrNH2 is good in selective voltammetric response to display of AM and AT. The electrochemical sensor is capable of simultaneously detecting the AM and the AT in drugs, has the characteristics of quickness, sensitivity, low cost, high selectivity and the like and has wide application prospects in the treatment field of cardiovascular diseases.
Description
Technical field
The present invention relates to a kind of preparation method of electrochemical sensor, relate in particular to a kind of preparation method of the electrochemical sensor based on the functional mesoporous silica modified electrode of magnetic nanoparticle doping simultaneously detecting for amiodarone and atenolol.
Background technology
In recent years, mesopore molecular sieve has caused a lot of concerns in electrochemical sensing field, mainly because it has good performance, as large surface area, large pore volume and narrow pore diameter distribution, and mesopore molecular sieve or a kind of efficiently, stablize, can be recycled and Eco-friendly material.Mobile crystalline material-41 (MCM-41) is a kind of mesoporous material with the unidirectional pore structure of one dimension six side, and this material is conventionally synthetic as structure directing agent with cationic surfactant under alkali condition.Silica MCM-41 mesopore molecular sieve surface is almost electric neutrality and acid site is few, has seriously limited its application.
In biofluid and drug sample, the detection of medicine is all very important to fields such as clinical chemistry, toxicology and pharmacy researchs, in the result for the treatment of of biofluid Chinese traditional medicine and its concentration, also has and contacts very closely; Therefore, can enough simple and quick methods detect multiple cardiovascular drugs, it is very important that the concentration of Cardiovarscular medicine used is carried out to immediately monitoring simultaneously.But in prior art, when using galvanochemistry sensing equipment relevant with other to cardiovascular drugs, the research of context of detection is also considerably less.
Electrochemical techniques have been used to the detection of multi-medicament compound, and conventionally do not have derivatization reaction, it is contemplated that and build a kind of electrochemical sensor, for these medicines of sensitiveer detection.But the report up to the present, also with electrochemical sensor, amiodarone (AM) and atenolol (AT) not being detected simultaneously.
Summary of the invention
The present invention relates to a kind of novel electrochemical sensor with magnetic pole simultaneously detecting for amiodarone (AM) and atenolol (AT).In order to overcome MCM-41 mesopore molecular sieve surface, be almost electroneutral feature, the present invention reacts in reflux in toluene with 3-aminopropyl triethoxysilane by MCM-41, the aminopropyl of functionalization is fixed to the surface of MCM-41 monox, form a kind of poroid magnetic nanometer composite material, combine the advantage of mesopore silicon oxide and magnetic nanoparticle., by magnetic field, measured object is separated easily from sample meanwhile, and do not needed to use extra organic solvent or the extra complicated programs such as filtration.
The preparation method who the present invention relates to a kind of electrochemical sensor simultaneously detecting for amiodarone and atenolol based on the functional mesoporous silica modified electrode of magnetic nanoparticle doping, its step is as follows:
(1) preparation of the colloidal suspensions of iron oxide magnetic nano particle: FeCl
36H
2o and FeCl
24H
2o is at N
2under atmosphere, be dissolved in distilled water, wherein, FeCl
36H
2o, FeCl
24H
2mass volume ratio (the w/w/v of O, distilled water, g/g/mL) be 100:50:1000～100:50:2000, the solution obtaining dropwise joins in the hydroxylamine solution that contains cetyl trimethyl ammonium bromide, forms a kind of colloidal suspensions of iron oxide magnetic nano particle.Cetyl trimethyl ammonium bromide and FeCl
36H
2the mass ratio (w/w, g/g) of O is 1:2～2:1, and the volume ratio (v/v, mL/mL) of hydroxylamine solution and distilled water is 1:2～2:1, and the concentration range of hydroxylamine solution is 1.5～5.5mol/L.
(2) Fe
2o
3-MCM-41-nPrNH
2synthetic: magnetic MCM-41 (Fe
2o
3-MCM-41) by iron oxide magnetic nano particle colloidal suspensions prepared by step (1), join magnetic force in the hydroxylamine solution that contains cetyl trimethyl ammonium bromide and mix rear ultrasonic agitation 1～3h, add after sodium silicate 35～60 ℃ to stir 12～20h, solid is leached, with the ammonium nitrate washing that contains ethanol 3～8 times; Synthetic material is removed to surfactant at 370～400 ℃ of calcining 6～8h, at this moment Fe
3o
4-MCM-41 just changes Fe into
2o
3-MCM-41, by Fe
2o
3-MCM-41 reacts and prepares Fe in reflux in toluene with 3-aminopropyl triethoxysilane
2o
3-MCM-41-nPrNH
2;
Wherein, volume ratio (the v/v/v of iron oxide magnetic nano particle colloidal suspensions, hydroxylamine solution and sodium silicate, mL/mL/mL) be: 10:100:1～10:250:5, mass volume ratio (the w/v of cetyl trimethyl ammonium bromide and hydroxylamine solution, g/mL) be 1:300～1:500, the concentration range of hydroxylamine solution is 1.5～5.5mol/L.
(3) Fe
2o
3-MCM-41-nPrNH
2the preparation of modified electrode: by carbon dust and Fe
2o
3-MCM-41-nPrNH
2with the ratio of mass ratio 85:15～95:5, mix, then to add mass percent be 15～25% mineral oil, hand mix is pastel, in mortar, grind 25～40min after drying at room temperature preserve; By pastel solid insert a cavity (diameter 2.5～3.5mm of polyfluortetraethylene pipe end, the degree of depth is 0.8～1.2mm) in, with a copper cash as connection, by electrode surface on pan paper gently friction carry out smooth treatment (this method is also used for to the electrode processing of regenerating), obtain Fe
2o
3-MCM-41-nPrNH
2modified electrode.
The inventive method relates to a kind of based on Fe
2o
3-MCM-41-nPrNH
2the preparation method of the electrochemical sensor of modified electrode, and detect for amiodarone and atenolol medicine time a kind of sensitive, cheap, detection method fast with high selectivity is provided.The electrochemical sensor modified electrode the present invention relates to also has the advantages such as repeatability, the wide range of linearity, low detectability, anti-surface contamination.Due to MCM-41-nPrNH
2and Fe
2o
3between there is very strong adhesion, and MCM-41-nPrNH
2solubleness in water is very low, and therefore, related electrochemical sensor of the present invention is highly stable.Load has Fe
2o
3mCM-41-nPrNH
2can strengthen anode current by electrode surface absorption amiodarone and atenolol, amiodarone and atenolol have been shown to good selectivity volt-ampere response, in medicine the two time the well-adapted method that provides is provided.
Embodiment
In order to deepen the understanding of the present invention, below in conjunction with implementing, the invention will be further described.
The preparation method of the electrochemical sensor simultaneously detecting for amiodarone and atenolol based on the functional mesoporous silica modified electrode of magnetic nanoparticle doping, its step is as follows:
(1) preparation of the colloidal suspensions of iron oxide magnetic nano particle: 3.0gFeCl
36H
2o and 1.5gFeCl
24H
2o is at N
2under atmosphere, be dissolved in 50mL distilled water, the solution obtaining dropwise joins in the hydroxylamine solution of the 50mL2.0mol/L that contains 1.5g cetyl trimethyl ammonium bromide, forms a kind of colloidal suspensions of iron oxide magnetic nano particle.
(2) Fe
2o
3-MCM-41-nPrNH
2synthetic: iron oxide magnetic nano particle colloidal suspensions prepared by 30mL step (1) joins in the hydroxylamine solution of the 500mL2.0mol/L that contains 1.5g cetyl trimethyl ammonium bromide, after magnetic force mixes, ultrasonic agitation is 1 hour, add after the sodium silicate of 10mL 40 ℃ to stir 18h, solid is leached, with the ammonium nitrate washing that contains ethanol 3 times; At 400 ℃ of calcining 6h, remove surfactant, at this moment Fe
3o
4-MCM-41 just changes Fe into
2o
3-MCM-41, by Fe
2o
3-MCM-41 reacts and prepares Fe in reflux in toluene with 3-aminopropyl triethoxysilane
2o
3-MCM-41-nPrNH
2.
(3) Fe
2o
3-MCM-41-nPrNH
2the preparation of modified electrode: by carbon dust and Fe
2o
3-MCM-41-nPrNH
2after mixing with the ratio of mass ratio 90:10, adding mass percent is 20% mineral oil, and hand mix is pastel, in mortar, grind 30min after drying at room temperature preserve; By pastel solid insert in a cavity (diameter 3mm, the degree of depth is 0.8mm) of polyfluortetraethylene pipe end, with a copper cash as connection, by electrode surface on pan paper gently friction carry out smooth treatment, obtain Fe
2o
3-MCM-41-nPrNH
2modified electrode.
Claims (6)
1. a preparation method for the electrochemical sensor simultaneously detecting for amiodarone and atenolol based on mesopore silicon oxide modified electrode, its step is as follows:
(1) preparation of the colloidal suspensions of iron oxide magnetic nano particle: FeCl
36H
2o and FeCl
24H
2o is at N
2under atmosphere, be dissolved in distilled water, the solution obtaining dropwise joins in the hydroxylamine solution that contains cetyl trimethyl ammonium bromide, forms a kind of colloidal suspensions of iron oxide magnetic nano particle; Wherein, described FeCl
36H
2o, FeCl
24H
2the mass volume ratio (w/w/v, g/g/mL) of O and distilled water is 100:50:1000～100:50:2000, described cetyl trimethyl ammonium bromide and FeCl
36H
2the mass ratio (w/w, g/g) of O is 1:2～2:1, and the volume ratio (v/v, mL/mL) of described hydroxylamine solution and distilled water is 1:2～2:1, and the concentration range of described hydroxylamine solution is 1.5～5.5mol/L;
(2) Fe
2o
3-MCM-41-nPrNH
2synthetic: magnetic MCM-41 (Fe
2o
3-MCM-41) by iron oxide magnetic nano particle colloidal suspensions prepared by step (1), join magnetic force in the hydroxylamine solution that contains cetyl trimethyl ammonium bromide and mix rear ultrasonic agitation 1～3h, add after sodium silicate 35～60 ℃ to stir 12～20h, solid is leached, with the ammonium nitrate washing that contains ethanol 3～8 times; Synthetic material is removed to surfactant at 370～400 ℃ of calcining 6～8h, at this moment Fe
3o
4-MCM-41 just changes Fe into
2o
3-MCM-41, by Fe
2o
3-MCM-41 reacts and prepares Fe in reflux in toluene with 3-aminopropyl triethoxysilane
2o
3-MCM-41-nPrNH
2;
Wherein, volume ratio (the v/v/v of described iron oxide magnetic nano particle colloidal suspensions, hydroxylamine solution and sodium silicate, mL/mL/mL) be 10:100:1～10:250:5, mass volume ratio (the w/v of described cetyl trimethyl ammonium bromide and hydroxylamine solution, g/mL) be 1:300～1:500, the concentration range of described hydroxylamine solution is 1.5～5.5mol/L;
(3) Fe
2o
3-MCM-41-nPrNH
2the preparation of modified electrode: by carbon dust and Fe
2o
3-MCM-41-nPrNH
2with the ratio of mass ratio 85:15～95:5, mix, then to add mass ratio be 15～25% mineral oil, hand mix is pastel, in mortar, grind 25～40min after drying at room temperature preserve; By pastel solid insert in cavity polyfluortetraethylene pipe end, diameter 2.5～3.5mm degree of depth 0.8～1.2mm, with a copper cash as connection, by electrode surface on pan paper gently friction carry out smooth treatment, obtain Fe
2o
3-MCM-41-nPrNH
2modified electrode.
2. the preparation method of electrochemical sensor according to claim 1, is characterized in that: the described FeCl of step (1)
36H
2o, FeCl
24H
2the mass volume ratio (w/w/v, g/g/mL) of O and distilled water is 30:15:500, described cetyl trimethyl ammonium bromide and FeCl
36H
2the mass ratio (w/w, g/g) of O is 1:2, and the volume ratio (v/v, mL/mL) of described hydroxylamine solution and distilled water is 1:1, and the concentration of described hydroxylamine solution is 2.0mol/L.
3. the preparation method of electrochemical sensor according to claim 1, it is characterized in that: the volume ratio (v/v/v of the described iron oxide magnetic nano particle of step (2) colloidal suspensions, hydroxylamine solution and sodium silicate, mL/mL/mL) be 30:500:10, mass volume ratio (the w/v of described cetyl trimethyl ammonium bromide and hydroxylamine solution, g/mL) be 3:1000, the concentration of described hydroxylamine solution is 2.0mol/L.
4. the preparation method of electrochemical sensor according to claim 1, is characterized in that: the described carbon dust of step (3) and Fe
2o
3-MCM-41-nPrNH
2the mixing quality of potpourri is than being 90:10, and the mass percent of described mineral oil and said mixture is 20%.
5. the preparation method of electrochemical sensor according to claim 1, is characterized in that: the described milling time of step (3) is 30min.
6. the preparation method of electrochemical sensor according to claim 1, is characterized in that: the described polyfluortetraethylene pipe end cavity diameter of step (3) is 3mm, and the degree of depth is 0.8mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410367527.8A CN104090008A (en) | 2014-07-29 | 2014-07-29 | Preparation method of electrochemical sensor based on mesoporous silica modified electrode |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410367527.8A CN104090008A (en) | 2014-07-29 | 2014-07-29 | Preparation method of electrochemical sensor based on mesoporous silica modified electrode |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104090008A true CN104090008A (en) | 2014-10-08 |
Family
ID=51637742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410367527.8A Pending CN104090008A (en) | 2014-07-29 | 2014-07-29 | Preparation method of electrochemical sensor based on mesoporous silica modified electrode |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104090008A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105806910A (en) * | 2016-03-18 | 2016-07-27 | 中国科学院成都生物研究所 | Biosensor achieving AChE oriented immobilization and preparation method and application of biosensor |
| CN106610396A (en) * | 2015-10-27 | 2017-05-03 | 济南大学 | Preparation method and use of MCM-41 mesoporous molecular sieve-modified carbon paste electrode |
| RU2838602C1 (en) * | 2024-12-25 | 2025-04-21 | Федеральное государственное бюджетное образовательно учреждение высшего образования "Уфимский университет науки и технологий" | Voltammetric sensor based on chiral complex ni (ii) immobilized on carboblack c for recognition of enantiomers of atenolol |
-
2014
- 2014-07-29 CN CN201410367527.8A patent/CN104090008A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| MOHAMMAD HASANZADEH, ET AL.: "Magnetic nanoparticles incorporated on functionalized mesoporous silica: an advanced electrochemical sensor for simultaneous determination of amiodarone and atenolol", 《RSC ADV. 》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106610396A (en) * | 2015-10-27 | 2017-05-03 | 济南大学 | Preparation method and use of MCM-41 mesoporous molecular sieve-modified carbon paste electrode |
| CN105806910A (en) * | 2016-03-18 | 2016-07-27 | 中国科学院成都生物研究所 | Biosensor achieving AChE oriented immobilization and preparation method and application of biosensor |
| CN105806910B (en) * | 2016-03-18 | 2018-11-13 | 中国科学院成都生物研究所 | A kind of biosensor and its preparation method and application of AChE enzymes directional at-tachment |
| RU2838602C1 (en) * | 2024-12-25 | 2025-04-21 | Федеральное государственное бюджетное образовательно учреждение высшего образования "Уфимский университет науки и технологий" | Voltammetric sensor based on chiral complex ni (ii) immobilized on carboblack c for recognition of enantiomers of atenolol |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Hao et al. | Metal-organic framework derived magnetic nanoporous carbon as an adsorbent for the magnetic solid-phase extraction of chlorophenols from mushroom sample | |
| CN105833834A (en) | Reduced graphene/ferroferric oxide/precious metal nanocomposite and preparation method and application thereof | |
| Duan et al. | An ultrasensitive lysozyme chemiluminescence biosensor based on surface molecular imprinting using ionic liquid modified magnetic graphene oxide/β-cyclodextrin as supporting material | |
| Chen et al. | A graphene oxide surface–molecularly imprinted polymer as a dispersive solid-phase extraction adsorbent for the determination of cefadroxil in water samples | |
| CN106085410B (en) | PEI modifies carbon dots-FITC compounds as ratio fluorescent pH probes and Cu2+The application of fluorescence probe | |
| CN104892839A (en) | Surface molecular imprinting polyion liquid of reduced graphene oxide for detecting bisphenol A and preparation method and application of surface molecular imprinting polyion liquid | |
| CN103278541A (en) | Electrochemical biosensor for detecting bisphenol-A, and preparation method and application thereof | |
| Ouyang et al. | A rapid and sensitive method for hydroxyl radical detection on a microfluidic chip using an N-doped porous carbon nanofiber modified pencil graphite electrode | |
| CN105866101A (en) | Heavy metal mercury ion detection method based on nucleic acid aptamer labeling | |
| CN101229504A (en) | Preparation and Application of Iron Oxide-Alumina Composite Nanomaterials for Fluoride Removal | |
| Xu et al. | Highly porous magnetite/graphene nanocomposites for a solid-state electrochemiluminescence sensor on paper-based chips | |
| Li et al. | Novel metal–organic framework materials in-focus detection and adsorption cues for environmental pollutants | |
| Sun et al. | Graphene quantum dots as additives in capillary electrophoresis for separation cinnamic acid and its derivatives | |
| Wu et al. | A highly sensitive electrochemical sensor for Cd (II) based on protic salt derived nitrogen and sulfur co-doped porous carbon | |
| CN102489273B (en) | Preparation method of magnetic beads of dendritic molecular imprinting polymer on surface of estrogenic nano silica gel | |
| CN104267078A (en) | Electrochemical sensor for quickly detecting melamine | |
| CN106084232B (en) | The preparation and application of fluorescence magnetic graphite oxide alkenyl 4- chlorophenol molecularly imprinted polymer | |
| CN104090008A (en) | Preparation method of electrochemical sensor based on mesoporous silica modified electrode | |
| CN103187134B (en) | The ferroferric oxide magnetic nanoparticle that four azepine cup [2] aromatic hydrocarbons [2] triazines are modified and preparation method and application | |
| CN109932449A (en) | A kind of preparation of magnetic porous graphene and its application in the rapid detection method of low concentration triclosan in water | |
| Yang et al. | A facile label-free electrochemiluminescence biosensor for target protein specific recognition based on the controlled-release delivery system | |
| CN103675063B (en) | A kind of preparation of DTPA functionalization graphene modified electrode and heavy metal survey method thereof | |
| CN105445398A (en) | Method for sensitively detecting phenol pollutants in environment water samples by solid-phase extraction-efficient liquid chromatography combined use | |
| Hu et al. | Application of molecular imprinting technology based on new nanomaterials in adsorption and detection of fluoroquinolones | |
| CN101811032B (en) | Preparation and application methods of Cd (II) imprinted magnetic material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141008 |