CN104083467B - 一种治疗慢性胃炎的中药制剂及其制备方法 - Google Patents
一种治疗慢性胃炎的中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种中药制剂及其制备方法，具体涉及一种治疗慢性胃炎的中药制剂及其制备方法，其特征在于按照质量份数计，由以下中药原料制备而成：海螵蛸8～10份、蒲公英15～20份、白矾1～2份、甘草3～5份、乳香3～5份、没药10～15份、元胡5～10份、三七5～10份和黄连10～15份。本发明的优点在于所使用的中药符合中华人民共和国药典规定，药物安全可靠。诸药相和具有抗胃溃疡、胃炎等功效，具有扶正祛邪，有止血止痛的作用，对胃肠功能失调，促进胃动力，使胃肠恢复正常功能。治疗慢性胃炎具有疗效确切、见效快、治愈率高、无副作用等特点。
Description
技术领域
本发明涉及一种中药制剂及其制备方法，具体涉及一种治疗慢性胃炎的中药制剂及其制备方法。
背景技术
慢性胃炎系指不同病因引起的各种慢性胃黏膜炎性病变，是一种常见病，其发病率在各种胃病中居首位。自纤维内镜广泛应用以来，对本病认识有明显提高。常见慢性浅表性胃炎、慢性糜烂性胃炎和慢性萎缩性胃炎。后者黏膜肠上皮化生，常累及贲门，伴有G细胞丧失和胃泌素分泌减少，也可累及胃体，伴有泌酸腺的丧失，导致胃酸，胃蛋白酶和内源性因子的减少。
慢性胃炎缺乏特异性症状，症状的轻重与胃黏膜的病变程度并非一致。大多数病人常无症状或有程度不同的消化不良症状如上腹隐痛、食欲减退、餐后饱胀、反酸等。慢性萎缩性胃炎患者可有贫血、消瘦、舌炎、腹泻等，个别病人伴黏膜糜烂者上腹痛较明显，并可有出血，如呕血、黑便。症状常常反复发作，无规律性腹痛，疼痛经常出现于进食过程中或餐后，多数位于上腹部、脐周、部分患者部位不固定，轻者间歇性隐痛或钝痛、严重者为剧烈绞痛。
西医西药的防治慢性胃炎手段，主要集中在制酸、修复胃粘膜、调节胃肠动力、杀灭幽门螺杆菌中的某一方面，因而不能给予慢性胃炎患者满意的治疗效果；同时，其潜在的耐药性问题也极大限制了其发展。相比而言，中医药依据理法方药的精神，参照四诊所见，确定胃病的具体证型，施予相应方药，从改善患者胃肠病理状况以及恢复胃肠功能两方面着手治疗慢性胃炎，在治疗中已取得一定成效，尤其是对病理学改变如炎症，胃黏膜萎缩，肠上皮化生或异型增生等，中医药更有优势。
发明内容
根据以上现有技术的不足，本发明提供一种治疗慢性胃炎的中药制剂及其制备方法，其疗效显著、安全可靠、无毒副作用，具有广阔的临床应用前景。
本发明所述的一种治疗慢性胃炎的中药制剂，按照质量份数计，由以下中药原料制备而成：海螵蛸8～10份、蒲公英15～20份、白矾1～2份、甘草3～5份、乳香3～5份、没药10～15份、元胡5～10份、三七5～10份和黄连10～15份。
其中，优选方案如下：
按照质量份数计，由以下中药原料制备而成：海螵蛸8份、蒲公英15份、白矾1份、甘草5份、乳香3份、没药10份、元胡5份、三七8份和黄连15份。
本发明所述的一种治疗慢性胃炎的中药制剂的制备方法，按照以下方法制备：按照配方称取中药原料并加入到容器中，加水漫过药面浸泡10～20分钟，再加水没过药面3～5厘米，用武火煎煮至沸腾再改用文火煎煮20～30分钟，取滤液；然后再加水没过药面3～5厘米，用武火煎煮至沸腾再改用文火煎煮15～20分钟，然后去渣取滤液，两次滤液合并即可。
服用时，每次300ml，一日两次。
药理分析：
海螵蛸：除湿，制酸，止血，敛疮。治胃痛吞酸，吐、衄、呕血，便血，崩漏带下，血枯经闭，腹痛症瘕，虚疟泻痢，阴蚀烂疮。收敛止血，涩精止带，用于胃痛吞酸，吐血衄血，崩漏便血，遗精滑精，赤白带下；溃疡病。外治损伤出血，疮多脓汁。
蒲公英：清热解毒，利尿散结。治急性乳腺炎，淋巴腺炎，瘰疬，疔毒疮肿，急性结膜炎，感冒发热，急性扁桃体炎，急性支气管炎，胃炎，肝炎，胆囊炎，尿路感染。
白矾：主要化学成分为十二水合硫酸铝钾。矿物质中药，外用能解毒杀虫，燥湿止痒；内用止血，止泻，化痰。主治：中风；癫痫；喉痹；疥癣湿疮；痈疽肿毒；水火烫伤；口舌生疮；烂弦风眼；聤耳流脓；鼻中息肉；疮痔疼痛；崩漏；衄血；损伤出血；久泻玖痢；带下阴痒；脱肛；子宫下垂等。白矾性味酸涩，寒，有毒。故有抗菌作用、收敛作用等，可用做中药。
甘草：补脾益气，清热解毒，祛痰止咳，清咽利嗓，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
乳香：味辛，热，微毒。调气活血，定痛，追毒。治气血凝滞、心腹疼痛，痈疮肿毒，跌打损伤，痛经，产后瘀血刺痛。
没药：又名末药。为橄榄科植物地丁树或哈地丁树的干燥树脂。主产于非洲索马里、埃塞俄比亚以及印度等地。采集由树皮裂缝处渗出的白色油胶树脂，于空气中变成红棕色而坚硬的圆块。打碎后，炒至焦黑色应用。主治胸腹瘀痛、痛经、经闭、症瘕、跌打损伤、痈肿疮疡、肠痈、目赤肿痛。有活血止痛、消肿生肌等功效。在东方是一种活血、化瘀、止痛、健胃的中药，来自产地古代阿拉伯及东非一带。
元胡：味辛、苦，性温。有活血散瘀，理气止痛的功能。用于全身各部气滞血瘀之痛，痛经，经闭，症瘕，产后瘀阻，跌扑损伤，疝气作痛。水煎服。
三七：主要分布于云南、广西、江西、四川等地。三七是以其根部入药，其性温，味辛，具有显著的活血化瘀、消肿定痛功效，有“金不换”、“南国神草”之美誉。因常在春冬两季采挖，又分为“春七”和“冬七”。由于三七同为人参属植物，而它的有效活性物质又高于和多于人参，因此又被现代中药药物学家称为“参中之王”。清朝药学著作《本草纲目拾遗》中记载：“人参补气第一，三七补血第一，味同而功亦等，故称人参三七，为中药中之最珍贵者。”扬名中外的中成药“云南白药”和“片仔癀”，即以三七为主要原料制成。主治咯血，吐血，衄血，便血，崩漏，外伤出血，胸腹刺痛，跌扑肿痛。
黄连：清热燥湿，泻火解毒。用于湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，血热吐衄，目赤，牙痛，消渴，痈肿疔疮；外治湿疹，湿疮，耳道流脓。酒黄连善清上焦火热。用于目赤，口疮。姜黄连清胃和胃止呕。用于寒热互结，湿热中阻，痞满呕吐。萸黄连舒肝和胃止呕。用于肝胃不和，呕吐吞酸。
本发明的优点在于所使用的中药符合中华人民共和国药典规定，药物安全可靠。诸药相和具有抗胃溃疡、胃炎等功效，具有扶正祛邪，有止血止痛的作用，对胃肠功能失调，促进胃动力，使胃肠恢复正常功能。治疗慢性胃炎具有疗效确切、见效快、治愈率高、无副作用等特点。
疗效判断：
选取慢性胃炎患者60例，男35例，女25例；年龄18～70岁，平均46.5岁；病程10周～2年，平均1.65年。服用本发明药物，每次300ml，一天两次。
诊断标准简介：参照中国中西医结合研究会消化系统疾病专业委员会制定的“慢性胃炎中西医结合诊断、辨证和疗效标准”(试行方案)辨证为脾胃湿热型。临床表现：上腹部或胃脘痞满灼热、胀痛，嗳气，或泛酸，口苦，口臭，舌红，苔黄厚或腻。胃镜检查：内镜下见胃黏膜明显水肿、充血、糜烂。
疗效判定标准：参照“慢性胃炎中西医结合诊断、辨证和疗效标准”(试行方案)，临床痊愈：临床主要症状均消失，胃镜复查活动性炎症消失，慢性炎症好转达轻度。显效：临床主要症状消失，次症基本消失，胃镜复查活动性炎症基本消失，慢性炎症好转。有效：主要症状明显减轻。胃镜复查黏膜病变范围缩小1/2以上，炎症有所减轻。无效：症状无改变，胃镜检查达不到有效标准，也无恶化者。
结果：显效42例，有效15例，无效3例，总有效率95％。
以下列举几个典型病例
1、韦某，男，56岁，山东青岛人，病历6年，症状胃脘部灼热隐痛6年，口苦，咽干，大便干结难解，3～5天1行，舌红，苔黄腻，医院门诊间断就诊，胃镜检查示：慢性糜烂性胃炎。经本发明药物施治，治疗14天后症状明显缓解，随访半年未见复发。
2、黄某，女，26岁，山东青岛人，病历1年，症状胃脘痞满胀痛，嗳气，口臭，舌红，苔黄厚。当地医院门诊间断就诊，胃镜检查示：慢性浅表性胃炎。经本发明药物施治，治疗7天后症状明显缓解，随访1年未见复发。
具体实施方式
以下通过实施例对本发明做进一步说明。
实施例1：
一种治疗慢性胃炎的中药制剂，按照质量份数计，由以下中药原料制备而成：海螵蛸8份、蒲公英15份、白矾1份、甘草5份、乳香3份、没药10份、元胡5份、三七8份和黄连15份。
实施例2：
按照实施例1的配方，按照以下方法制备治疗慢性胃炎的中药制剂：按照配方称取中药原料并加入到容器中，加水漫过药面浸泡20分钟，再加水没过药面3厘米，用武火煎煮至沸腾再改用文火煎煮20分钟，取滤液；然后再加水没过药面3厘米，用武火煎煮至沸腾再改用文火煎煮15分钟，然后去渣取滤液，两次滤液合并即可。
Claims (1)
1.一种治疗慢性胃炎的中药制剂，其特征在于按照质量份数计，由以下中药原料制备而成：海螵蛸8份、蒲公英15份、白矾1份、甘草5份、乳香3份、没药10份、元胡5份、三七8份和黄连15份；
所述治疗慢性胃炎的中药制剂的制备方法为，按照配方称取中药原料并加入到容器中，加水漫过药面浸泡10～20分钟，再加水没过药面3～5厘米，用武火煎煮至沸腾再改用文火煎煮20～30分钟，取滤液；然后再加水没过药面3～5厘米，用武火煎煮至沸腾再改用文火煎煮15～20分钟，然后去渣取滤液，两次滤液合并即可。
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