CN104068841A - Measuring method and device for measuring systole time parameter - Google Patents
Measuring method and device for measuring systole time parameter Download PDFInfo
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Abstract
The invention discloses a measuring method and device for measuring a systole time parameter. The measuring method comprises the steps of acquisition of a pulse oximeter signal, automatic extraction of a characteristic point and digital correction of a characteristic parameter. The device is taken as a hardware carrier of the method. More accurate LVET (Left Ventricular Ejection Time) and measuring results of relevant parameters are obtained on the basis of the pulse oximeter signal by means of a simple measure in order to rapidly obtain clinical diagnostic data related to initial screening of heart disease and cardiac function evaluation. Photoplethysmography equipment for realizing the functions comprises a pulse oximeter signal acquisition unit, a signal processing unit and a data output unit. The entire device is easy to wear, is low in manufacturing cost, and contributes to reduction of the cost on cardiovascular function evaluation and disease monitoring.
Description
Technical field
The present invention relates to method and the device for clinical heart function parameter, measured, particularly relate to a kind of measuring method and device of measuring Indices of Systolic Time parameter.
Background technology
Left ventricular ejection time (LVET) refers in each cardiac cycle, and during left ventricular contraction, blood enters by the aortic valve of opening the time that this process of large artery trunks experiences.A large amount of clinical experiment results show that LVET and the parameter being derived by it have important clinical meaning aspect examination of heart disease initial stage and cardiac function assessment.In prior art, the measuring method of LVET has intrusive mood and the large class of non-intrusion measurement two.Intrusive mood is measured a conduit is inserted into large artery trunks root, can accurately measure LVET, but need to be operated by professional health care personnel, and expense is higher, and can bring strong misery to the measured.
At non-intrusion type apoplexy due to endogenous wind, heart image technique can provide comparatively accurate LVET measuring method.Application number is that the patent of invention of WO2006024088A1 proposes to measure LVET on the tachogram that utilizes Doppler technology record.The shortcoming of this technology is to need equipment with high costs and highly difficult operant skill, and is difficult to realize continuous measurement; Patent CN103491868A proposes to measure LVET from wearable cardiac impedance is traced the cardiac impedance signal of system log (SYSLOG), this systematic comparison is complicated, need to settle a plurality of electrodes with it measured, and very strict to the requirement of detection position, the stability of signal and repeatability are all not ideal enough; Patent US4446872 has proposed to measure the method for LVET on periphery arterial pulse wave, the method is used piezoelectric transducer to measure carotid pulse wave, and in single cardiac cycle the rising edge starting point of pulse wave and the interval between trailing edge flex point as the valuation of LVET, clinical data shows, the LVET value that the LVET that this method detection obtains records with intrusive mood method has very strong dependency, but this method is strict to also detection position being required, and is not easy to continuous measurement.
Summary of the invention
In above-mentioned prior art, intrusive mood is measured and need to be operated by professional health care personnel, and expense is higher, and can bring strong misery to the measured; Non-intrusion measurement exists that equipment is complicated, operation easier is high, the stability of signal and repeatability all not ideal enough, be not easy to the also problem such as undesirable of continuous measurement, actual life.For the problems referred to above, the invention provides a kind of non-intrusion measurement method and device of the novel parameter of Indices of Systolic Time easily.
Particularly, the measuring method of a kind of Indices of Systolic Time parameter provided by the invention and device solve the problems referred to above by following technical essential:
The application provides a kind of measuring method of measuring Indices of Systolic Time parameter, and blood enters the time that large artery trunks experiences and the parameter being derived by it by the aortic valve of opening when measuring left ventricular contraction, comprises the following steps:
A) adopt photoelectricity volume ripple tracing from human body tip tissue sampling photoelectricity volume pulse wave signal;
B) the feature reference point on the photoelectricity volume pulse wave signal in each cardiac cycle by peak search algorithm, last step being obtained detects automatically, comprising: the first reference point (rising edge starting point), the second reference point (peak systolic point), the 3rd reference point (relaxing period peak point);
C) on the first derivative curve of pulse wave, search for the 4th reference point (trailing edge flex point);
D) set up mathematical model, interval between the first reference point to the four reference points is revised, to calculate left ventricular ejection time LVET, that is: note the first reference point is that t1, the 4th reference point are t4 constantly constantly, LVET=a* (t4-t1)+b, wherein a and b serve as reasons and take the concrete numerical value obtaining in the contrast test that intrusive mood method or heart image technique be reference;
E) calculate ventricular ejection time index LVETI: with the interval between the first reference point of adjacent two cardiac cycles as cardiac cycle length, and calculate current heart rate with this cardiac cycle length, utilize mathematical model to revise LVET, thereby obtain LVETI, concrete mathematical model is: LVETI=LVET+c* heart rate, wherein, c is constant, gets 0.0016.
Wherein, described step c) performing step is: from the moment corresponding to the 3rd reference point, sweep backward on the first derivative curve of volume pulsation wave, before reaching the second reference point, once curve values is by just becoming negative when searching certain, search stops, this time be engraved in original waveform corresponding point and be the 4th reference point; If do not find yet the point of this first derivative curve values sign modification when reaching the second reference point,, in certain subinterval between second and third reference point, the moment of first derivative absolute value minimum was considered to for the 4th moment corresponding to reference point.
Further, also comprise step f), described step f) be a) to e to each cardiac cycle repeating step in a period of time), obtain the meansigma methods of LVET and LVETI; Or to repeating step in the cycle a period of time a) to c) obtain t1 and the t4 of each cardiac cycle, the meansigma methods of getting respectively above-mentioned t1 and t4, and meansigma methods is applied to steps d) and e), obtain the meansigma methods of LVET and LVETI.
Further, described step a) and step b) between also comprise filter step, described filter step is carried out Filtering Processing for the photoelectricity volume pulse wave signal that step is gathered in a), eliminates low frequency movement noise jamming.
The application also provides a kind of device of measuring Indices of Systolic Time parameter, comprise that described signal gathering unit and data output unit are connected on the input and outfan of information process unit for the signal gathering unit from the collection of human body tip tissue sampling photoelectricity volume pulse wave signal, for the information process unit of date processing and the data output unit showing for result.
Wherein, between described signal gathering unit and information process unit, be also provided with analog-digital converter, the frequency spectrum acquisition range of described signal gathering unit is 0.05-35hz, between described analog-digital converter and signal gathering unit, be also provided with wave trap, described wave trap is for eliminating the power frequency interference signals of 50hz.
Wherein, between described signal gathering unit and analog-digital converter, be also provided with Signal Pretreatment unit.
Wherein, described Signal Pretreatment unit comprises at least one among wave filter and signal amplifier.
Wherein, described data output unit comprises at least one in display unit, data transmission unit.
Wherein, on described information process unit, be also provided with the control unit for control information processing unit.
The invention provides one or more technical schemes, at least there is following beneficial effect or advantage:
1, the present invention proposes a kind of mathematical model that test is set up based on clinical comparison, by the desirable value obtaining according to the step of mathematical model, the characteristic parameter extracting from photoelectricity volume pulse wave signal is revised, thereby be convenient to adopt simple method to obtain more accurate LVET measurement result; The equipment cost that simultaneously realizes above function is low, is conducive to reduce the equipment investment of cardiovascular function assessment and disease surveillance.
2, the present invention proposes the method for automatic extract minutiae on the basis of photoelectricity volume pulse wave signal, particularly utilize pulse wave rising edge starting point and trailing edge flex point wherein, can realize LVET, LVETI in Measuring Time section or the monitoring of other index parameter, be conducive to automatically obtain a plurality of assessment data about the examination of heart disease initial stage and cardiac function assessment aspect.
3, the invention provides a kind of measuring method and device of measuring Indices of Systolic Time parameter, usage range is wide, be applicable to any hope automatically measures in the detection application of LVET and relevant parameter from photoelectricity volume pulse wave signal, as method and apparatus provided by the invention is combined with electrocardio, heart sound signal acquisition and analytical system, can automatically detect more clinical parameters about cardiac function assessment such as heart rate, LVET, LVETI, PEP, LVET/PEP.
Accompanying drawing explanation
Fig. 1 is a kind of measurement procedure figure that measures a specific embodiment of Indices of Systolic Time parametric technique of the present invention;
Fig. 2 is in a kind of measuring method of measuring Indices of Systolic Time parameter of the present invention, the schematic diagram of a specific embodiment of the automatic Detection and Extraction of pulse wave feature reference point, wherein, two waveforms in top in Fig. 2 are pulse wave: P, and two waveforms in below in Fig. 2 are respectively pulse wave derivative corresponding to each moment t of two pulse wave P: dP/dt;
Fig. 3 be interval between photoelectricity volume pulsation rising edge starting point and flex point and from cardiac ultrasonic figure the Linear Fit Chart between the actual LVET recording;
Fig. 4 is a kind of topological diagram of measuring a specific embodiment of device of Indices of Systolic Time parameter of the present invention.
The specific embodiment
The invention provides a kind of measuring method and device of measuring Indices of Systolic Time parameter, for solving: intrusive mood is measured and need to be operated by professional health care personnel, expense is higher and can bring the strong problems such as misery to the measured; The equipment that exists in existing non-intrusion measurement is complicated, operation easier is high, the stability of signal and repeatability all not ideal enough, be not easy to the also problem such as undesirable of continuous measurement, actual life.Method provided by the invention and device can be realized and adopt simple method to obtain more accurate LVET measurement result, automatically obtain the assessment data about the examination of heart disease initial stage and cardiac function assessment aspect.The realization approach of above technique effect is to settle photoelectric sensor at human body tip tissue, the mathematical model of setting up is tested in utilization by clinical comparison, the characteristic parameter extracting from photoelectricity volume pulse wave signal is revised, and provided one or more hardware supported for said method.Below in conjunction with embodiment, the present invention is described in further detail, but measuring method of the present invention and device are not limited only to following examples:
Embodiment 1:
As shown in Figures 1 to 4, the application provides a kind of measuring method of measuring Indices of Systolic Time parameter, blood enters the time LVET that large artery trunks experiences and the parameter being derived by it by the aortic valve of opening when measuring left ventricular contraction, comprises the following steps:
A) adopt photoelectricity volume ripple tracing from human body tip tissue sampling photoelectricity volume pulse wave signal;
B) the feature reference point on the photoelectricity volume pulse wave signal in each cardiac cycle by peak search algorithm, last step being obtained detects automatically, comprising: the first reference point (rising edge starting point), the second reference point (peak systolic point), the 3rd reference point (relaxing period peak point);
C) on the first derivative curve of pulse wave, search for the 4th reference point (trailing edge flex point);
D) setting up mathematical model revises interval between the first reference point to the four reference points, to calculate LVET, that is: note the first reference point is that t1, the 4th reference point are t4 constantly constantly, LVET=a* (t4-t1)+b, wherein a and b serve as reasons and take the concrete numerical value obtaining in the contrast test that intrusive mood method or heart image technique be reference;
E) calculate ventricular ejection time index LVETI: with the interval between the first reference point of adjacent two cardiac cycles as cardiac cycle length, and calculate current heart rate with this cardiac cycle length, utilize mathematical model to revise LVET, thereby obtain LVETI, concrete mathematical model is: LVETI=LVET+c* heart rate, wherein, c is constant, gets 0.0016.
The application also provides a kind of device of measuring Indices of Systolic Time parameter, comprise that described signal gathering unit and data output unit are connected on the input and outfan of information process unit for the signal gathering unit from the collection of human body tip tissue sampling photoelectricity volume pulse wave signal, for the information process unit of date processing and the data output unit showing for result.
The photoelectricity volume ripple tracing using in the present embodiment is used specific light source, as visible red, green glow or infrared ray searchlighting human body tip tissue, such as finger, ear-lobe or toe etc., according to the light intensity of reflected light or transillumination, change the changing condition of blood flow in the blood vessel causing while measuring pulse pollex.Concrete, the signal gathering unit of setting is used for from human body tip tissue sampling photoelectricity volume pulse wave signal, and in the present embodiment, the signal gathering unit of setting is photoelectricity volume pulse wave signal sensor; The information process unit arranging has been used for the b in the present embodiment method step) to e), on the basis of photoelectricity volume pulse wave signal automatically extract minutiae, the characteristic parameter correction of extracting is obtained to the measurement of more accurate LVET, LVETI, heart rate or other index parameters, conveniently obtain a plurality of assessment data about the examination of heart disease initial stage and cardiac function assessment aspect; The photoelectricity volume ripple of simultaneously realizing above function trace equipment be easy to wear, cheap, be conducive to reduce the cost of cardiovascular function assessment and disease surveillance.
The method and apparatus that the present embodiment provides applies in one group of clinical trial, uses a M-type ultrasonic device and photoelectricity volume pulse tracing equipment at each measured individuality synchronous acquisition aortic valve moving image and finger tip volume pulsation wave signal with it.In each cardiac cycle, the opening and closing of labelling aortic valve point on ultrasonoscopy, and using the spacing of this point-to-point transmission as current left ventricular contraction time LVET.Further, utilize the method proposing in the present invention automatically on pulse wave signal, to extract the interval between rising edge starting point and trailing edge flex point, be designated as t4 – t1.
Fig. 3 has shown the test data obtaining from 11 the measured with it.In figure, transverse axis represents the true LVET measuring from ultrasonoscopy, and the longitudinal axis represents the interval t4 – t1 measuring from pulse wave.In order to eliminate the impact of breathing cycle, these measurement results are all to take from from it each individuality, the meansigma methods of 15 seconds signal acquisitions of continuous record.
As can be seen from Figure 3, although t4 – t1 has obvious linear relationship with LVET, numerically obviously higher.Therefore,, in order to obtain LVET valuation accurately from pulse wave, the invention provides mathematical model t4 – t1 is revised.A kind of method of a of obtaining and the concrete numerical value of b is also provided in the present embodiment:
1) use intrusive mood or heart image technique accurately to measure LVET, and using this as with reference to value, at tip tissue registration photoelectricity volume pulse wave signal, and automatic extraction time characteristic point, thereby obtain t4 – t1;
2) the LVET reference value obtaining and t4 – t1 are carried out to linear fit, thereby obtain the concrete numerical value of a and b;
3) utilize the characteristic point t1 automatically extracting from volume ripple, t4 and mathematical model LVET=a * (t4 – t1)+b accurately estimate LVET.
In the present embodiment by above step 1) and 2), obtain one group of accurate a and the concrete numerical value of b to apply to the popularization of follow-up mathematical model, step 2) method of neutral line matching can adopt method of least square.
Get and be no less than 10 groups of subjects and repeat above-mentioned steps 1) and 2), the concrete numerical value of one group of a and b finally obtained: a is that 1.67, b is 268.
In the example shown in Fig. 3, LVET=1.67 * (t4 – t1)-268.
In the present embodiment, a point of getting arbitrarily in Fig. 3 carries out numerical analysis, now gets in Fig. 3 the 2nd point from left to right.With reference to LVET, come from M-type cardiac ultrasonic image, the average value measured in 15 seconds is 310 milliseconds, and the meansigma methods of the t4 – t1 measuring from volume ripple in 15 seconds is 345 milliseconds.After using mathematical model LVET=1.67 * (t4 – t1) – 268 to revise, the LVET value measuring from volume ripple is 308 milliseconds, and error rate is only 6/1000ths of reference value.
Embodiment 2:
The present embodiment is further qualified on the basis of embodiment 1, as shown in Figure 1, described step c) performing step is: from the moment corresponding to the 3rd reference point, sweep backward on first derivative curve, before reaching the second reference point, once curve values is by just becoming negative when searching certain, search stops, this time be engraved in original waveform corresponding point and be the 4th reference point; If do not find yet the point of this first derivative curve values sign modification when reaching the second reference point,, in the subinterval between second and third reference point, the moment of first derivative absolute value minimum was considered to for the 4th moment corresponding to reference point.Above step is for realizing c) step provides a kind of concrete grammar, the 4th reference point obtaining according to this method accurately constantly, the all result errors that obtain in Measuring Time section are little, be that numerical value has repeatability, simultaneously, adopt this kind of method to measure trailing edge flex point efficiency high: as a kind of preferred version, this time period of 50 ms before 50 ms to the three reference points after desirable the second reference point in subinterval in the present embodiment.
For avoiding measurement data, disturbed in short-term, as the impact bringing due to the measured anxious state of mind, the result that makes to obtain fails to react testee's truth, in the present embodiment, also provide and repeatedly measured the method for averaging:, further, also comprise step f), described step f) be a) to e to each repeating step aroused in interest in a period of time), obtain the meansigma methods of LVET and LVETI; Or to repeating step in the cycle a period of time a) to c) t1 and the t4 of each cardiac cycle of obtaining, the meansigma methods of getting respectively above-mentioned t1 and t4, and meansigma methods is applied to steps d) and e), obtain the meansigma methods of LVET and LVETI.
Further, for ease of obtaining the value of photoelectricity volume pulse wave signal collection more clearly, described step a) and step b) between also comprise filter step, described filter step is carried out Filtering Processing for the photoelectricity volume pulse wave signal that step is gathered in a), eliminates low frequency movement noise jamming.
Embodiment 3:
The present embodiment is further qualified on the basis of embodiment 1, as shown in Figure 4, between described signal gathering unit and information process unit, be also provided with analog-digital converter, the frequency spectrum acquisition range of described signal gathering unit is 0.05-35hz, between described analog-digital converter and signal gathering unit, be also provided with wave trap, described wave trap is for eliminating the power frequency interference signals of 50hz.The analog-digital converter arranging is for carrying out follow-up digitized processing to collected signal; The restriction of the frequency spectrum acquisition range of signal gathering unit is intended to guarantee to gather the data acquisition amount that as far as possible reduces signal gathering unit on the basis of desired signal frequency band, is conducive to reduce date processing cost of the present invention; The interference that the wave trap arranging produces certainty of measurement of the present invention for eliminating power frequency component.
For ease of the present invention, can access measured value output more accurately, between described signal gathering unit and analog-digital converter, also be provided with Signal Pretreatment unit.Wherein, described Signal Pretreatment unit comprises at least one among wave filter and signal amplifier.
Can be single or whole realizations are local checks and remote results transmission for ease of the present invention, described data output unit comprises at least one in display unit, data transmission unit.
For ease of parameter adjustment of the present invention and feature richness, on described information process unit, be also provided with the control unit for control information processing unit.
Embodiment 4:
The present embodiment is further qualified on the basis of embodiment 1, as shown in 2, the present invention is realizing employing photoelectricity volume ripple tracing from the step of human body tip tissue sampling photoelectricity volume pulse wave signal, can obtain pulse wave signal clearly, inspection by information process unit to reference point in pulse wave signal, makes the present embodiment that a kind of device that utilizes photoelectricity volume pulse wave signal to measure LVET and relevant parameter thereof is provided.
Above content is the further description of the present invention being done in conjunction with concrete preferred implementation, can not assert that the specific embodiment of the present invention is confined to these explanations.For general technical staff of the technical field of the invention, not departing from other embodiments that draw under technical scheme of the present invention, all should be included in protection scope of the present invention.
Claims (10)
1. measure a measuring method for Indices of Systolic Time parameter, blood enters the time that large artery trunks experiences and the parameter being derived by it by the aortic valve of opening when measuring left ventricular contraction, it is characterized in that, comprises the following steps:
A) adopt photoelectricity volume ripple tracing from human body tip tissue sampling photoelectricity volume pulse wave signal;
B) the feature reference point on the photoelectricity volume pulse wave signal in each cardiac cycle by peak search algorithm, last step being obtained detects automatically, comprising: the first reference point (rising edge starting point), the second reference point (peak systolic point), the 3rd reference point (relaxing period peak point);
C) on the first derivative curve of pulse wave, search for the 4th reference point (trailing edge flex point);
D) set up mathematical model, interval between the first reference point to the four reference points is revised, to calculate left ventricular ejection time LVET, that is: note the first reference point is that t1, the 4th reference point are t4 constantly constantly, LVET=a* (t4-t1)+b, wherein a and b serve as reasons and take the concrete numerical value obtaining in the contrast test that intrusive mood method or heart image technique be reference;
E) calculate ventricular ejection time index LVETI: with the interval between the first reference point of adjacent two cardiac cycles as cardiac cycle length, and calculate current heart rate with this cardiac cycle length, utilize mathematical model to revise LVET, obtain LVETI, concrete mathematical model is: LVETI=LVET+c* heart rate, wherein, c is constant, gets 0.0016.
2. a kind of measuring method of measuring Indices of Systolic Time parameter as claimed in claim 1, it is characterized in that, described step c) performing step is: from the moment corresponding to the 3rd reference point, sweep backward on the first derivative curve of volume pulsation wave, before reaching the second reference point, once curve values is by just becoming negative when searching certain, search stops, this time be engraved in original waveform corresponding point and be the 4th reference point; If do not find yet the point of this first derivative curve values sign modification when reaching the second reference point,, in certain subinterval between second and third reference point, the moment of first derivative absolute value minimum was considered to for the 4th moment corresponding to reference point.
3. a kind of measuring method of measuring Indices of Systolic Time parameter as claimed in claim 1, it is characterized in that, also comprise step f), described step f) be a) to e to each cardiac cycle repeating step in a period of time), obtain the meansigma methods of LVET and LVETI; Or to repeating step in the cycle a period of time a) to c) t1 and the t4 of each cardiac cycle of obtaining, the meansigma methods of getting respectively above-mentioned t1 and t4, and meansigma methods is applied to steps d) and e), obtain the meansigma methods of LVET and LVETI.
4. a kind of measuring method of measuring Indices of Systolic Time parameter as claimed in claim 1, it is characterized in that, described step a) and step b) between also comprise filter step, described filter step is carried out Filtering Processing for the photoelectricity volume pulse wave signal that step is gathered in a), eliminates low frequency movement noise jamming.
5. a device of measuring Indices of Systolic Time parameter, it is characterized in that, comprise that described signal gathering unit and data output unit are connected on the input and outfan of information process unit for the signal gathering unit from human body tip tissue sampling photoelectricity volume pulse wave signal, for the information process unit of date processing and the data output unit showing for result.
6. a kind of device of measuring Indices of Systolic Time parameter according to claim 5, it is characterized in that, between described signal gathering unit and information process unit, be also provided with analog-digital converter, the frequency spectrum acquisition range of described signal gathering unit is 0.05-35hz, between described analog-digital converter and signal gathering unit, be also provided with wave trap, described wave trap is for eliminating the power frequency interference signals of 50hz.
7. a kind of device of measuring Indices of Systolic Time parameter according to claim 6, is characterized in that, is also provided with Signal Pretreatment unit between described signal gathering unit and analog-digital converter.
8. a kind of device of measuring Indices of Systolic Time parameter according to claim 5, is characterized in that, described Signal Pretreatment unit comprises at least one among wave filter and signal amplifier.
9. according to a kind of device of measuring Indices of Systolic Time parameter described in any one in claim 5 to 8, it is characterized in that, described data output unit comprises at least one in display unit, data transmission unit.
10. according to a kind of device of measuring Indices of Systolic Time parameter described in any one in claim 5 to 8, it is characterized in that, on described information process unit, be also provided with the control unit for control information processing unit.
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| CN109171677A (en) * | 2018-09-20 | 2019-01-11 | 芯海科技（深圳）股份有限公司 | A kind of Portable type measurement unit and the hemodynamic parameter measurement method based on the device |
| CN114173647A (en) * | 2019-06-18 | 2022-03-11 | 生命解析公司 | Method and system for assessing disease using dynamic analysis of cardiac and photoplethysmographic signals |
| CN111214218A (en) * | 2020-01-13 | 2020-06-02 | 京东方科技集团股份有限公司 | Detection equipment for multiple physiological parameters |
| CN111214218B (en) * | 2020-01-13 | 2024-02-09 | 京东方科技集团股份有限公司 | Multi-physiological parameter detection equipment |
| WO2024167522A1 (en) * | 2023-02-06 | 2024-08-15 | Medici Technologies, LLC | Noninvasive structural and valvular abnormality detection system based on flow aberrations |
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