CN104044286A - Method and apparatus for encapsulating rigid insert in contact lens for correcting vision in astigmatic patients - Google Patents
Method and apparatus for encapsulating rigid insert in contact lens for correcting vision in astigmatic patients Download PDFInfo
- Publication number
- CN104044286A CN104044286A CN201410096328.8A CN201410096328A CN104044286A CN 104044286 A CN104044286 A CN 104044286A CN 201410096328 A CN201410096328 A CN 201410096328A CN 104044286 A CN104044286 A CN 104044286A
- Authority
- CN
- China
- Prior art keywords
- ophthalmic lens
- insert
- front curve
- rock
- rigidity insert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/00038—Production of contact lenses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/00038—Production of contact lenses
- B29D11/00048—Production of contact lenses composed of parts with dissimilar composition
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/0074—Production of other optical elements not provided for in B29D11/00009- B29D11/0073
- B29D11/00807—Producing lenses combined with electronics, e.g. chips
- B29D11/00817—Producing electro-active lenses or lenses with energy receptors, e.g. batteries or antennas
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
Abstract
The present invention, as described above and as further defined by the claims below, provides methods for forming an ophthalmic lens that encapsulates a rigid insert, wherein the rigid insert may be tailored to correct specific astigmatic characteristics of an eye and apparatus for implementing such methods, as well as ophthalmic lenses formed with the rigid inserts.
Description
Technical field
The invention describes and relate to the method for sealing aspect, equipment and the device relevant with Ophthalmoligic instrument, and more specifically, in certain embodiments, described aspect the sealing of the manufacture of the haptic lens for astigmatic eyes and sealing.
Background technology
Traditionally, Ophthalmoligic instrument (such as haptic lens or intraocular lens) is included in and there is rectification, improve looks or treat in the biocompatible device of characteristic.For example, haptic lens can provide vision correction functional, beauty treatment strengthen and result for the treatment of in one or more.The physical characteristic of ophthalmic lens can provide every kind of function.Refracting characteristic is incorporated to the design in ophthalmic lens, vision correction function can be provided.The pigment mixing in ophthalmic lens can provide beauty treatment to strengthen.The activating agent mixing in ophthalmic lens can provide treatment functional.
Astigmatic eyes is often by the cornea of eyes or lenticular irregular or common optical defect that protuberantia curvature causes.So, the solution that astigmatism eye patient's eyesight need to be more complicated than typical haptic lens.Therefore need in recent years to have other method and apparatus that contributes to the ophthalmic lens that forms eyesight that can astigmatism patient.In recent years, rigidity insert is included in ophthalmic lens, wherein said rigidity insert can increase to ophthalmic lens functional.Therefore, the sealing in ophthalmic lens and to seal relevant new method, device and equipment be important with rigidity insert.
Summary of the invention
Therefore, the present invention includes the new invention relevant with the method that forms the ophthalmic lens that contains rigidity insert.In certain embodiments, can carry out pre-filled front curve mold component with reactive monomer mixture, and rigidity insert can be placed on described reactive monomer mixture.Can make the precuring of described reactive monomer mixture, to keep securely the contiguous described front curve mould of described rigidity insert, wherein said precuring meeting forms front curve assembly.In certain embodiments, described front curve component process can be carried out by automation equipment.
After can coming with reactive monomer mixture, fill described front curve assembly, wherein said pre-filled and described rear filling can be sealed described rigidity insert.Can be close to described front curve assembly and place back curve mold part, wherein said placement can form front curve and rear curved surface assembly.In certain embodiments, can make the precuring of described reactive monomer mixture, to keep securely the contiguous described front curve assembly of described back curve mold.
Can make described reactive monomer mixture solidified to form ophthalmic lens.Then described front curve and the demoulding of rear curved surface assembly can be made, and ophthalmic lens can be taken out.Then can be by described ophthalmic lens hydration, for example, by approximately 50 DEG C of temperature, described ophthalmic lens is immersed in the solution that comprises about 0.45% Boratex at least 1 hour.In certain embodiments, the reactive monomer mixture of described polymerization can comprise hydrogel, for example, and silicone hydrogels.
In certain embodiments, described rigidity insert can comprise adhesion promoting layer.Can be by degassed to rigidity insert, reactive monomer mixture, front curve mould and back curve mold before for described method, wherein said degassed meeting removes the gas that can produce defect of lens.In certain embodiments, can on pallet, form multiple ophthalmic lens that contain rigidity insert simultaneously.
In certain embodiments, described rigidity insert can astigmatism eyesight.In such embodiments, described rigidity insert can comprise hot formed material.Rock-steady structure can be added in described reactive monomer mixture, wherein said rock-steady structure can make ophthalmic lens directed on eyes.Can make described rock-steady structure align with described rigidity insert, wherein said alignment allows astigmatism eyesight in the time that described ophthalmic lens is directed on eyes.In certain embodiments, described rigidity insert can comprise rock-steady structure, for example, and by hot forming process.In other embodiments, described rock-steady structure can be injectable material, and described injectable material comprises the inflatable index different from described reactive monomer mixture.
Described rock-steady structure can change the front curve surface of ophthalmic lens, or can increase quality to ophthalmic lens, and wherein said quality is enough to make ophthalmic lens directed on eyes.Described rock-steady structure can comprise visual orientation mark, and wherein said visual orientation mark comprises visible painted or mark.
Brief description of the drawings
Fig. 1 has explained an exemplary embodiment of the ophthalmic lens that contains the rigidity insert of sealing completely, the eyesight that wherein said ophthalmic lens can astigmatism patient.
Fig. 2 has explained that a substituting Fig. 1 has explained exemplary mold component devices parts, and it can be for realizing some embodiments of the present invention.
Fig. 3 has explained exemplary mold component devices parts, and it can be for realizing some embodiments of the present invention.
Fig. 4 has explained the method step that forms the haptic lens that contains the rigidity insert of sealing according to some embodiments of the present invention.
Fig. 5 has explained an example of the part of appliance for rigidity insert being put into ophthalmic lens mold parts.
Detailed description of the invention
The present invention includes the method and apparatus for the manufacture of the ophthalmic lens that contains rigidity insert, wherein said rigidity insert astigmatism patient's eyesight.In addition, the present invention includes the ophthalmic lens that contains rigidity insert obtaining.Generally speaking, according to some embodiments of the present invention, rigidity insert can be integrated in ophthalmic lens via automatic operation, and described automatic operation is put into rigidity insert the position of expectation for being used to form the mold component of ophthalmic lens.
At present, there is the ophthalmic lens for astigmatism eye.For example, permeable the gas of rigidity eyeglass can be placed on above cornea, and can between eyeglass and eyes, form tear layer.The permeable eyeglass of gas of described rigidity serves as new cornea substantially, and it can be designed to imitate the curvature of non-astigmatic eyes.This technology is considered shelters.But the permeable eyeglass of gas of typical rigidity is uncomfortable and expensive.
Soft contact lens sector-meeting provides more comfortable and more cheap replacement scheme.Unlike the permeable eyeglass of gas (RGP) of rigidity, can between eyes and eyeglass, not form tear layer; So, can customize the astigmatic feature of soft contact lens sheet with reflection eyes.Described eyeglass can contain different refracting powers and the refraction angle each part with correction ocular.But because described eyeglass is soft, described eyeglass adapts to the shape of eyes naturally to a certain extent.This can reduce the validity of eyeglass, and the often fuzzy or diplopia of complaint of user.
Comfortable and the validity problem of any scheme can increase the weight of in the patient with severe astigmatism eye.Therefore, the invention provides the novel replacement scheme for astigmatism patient's eyesight.Described the ophthalmic lens that can comprise rigidity insert, and more specifically, the rigidity insert of wherein sealing can provide the rectification to astigmatic eyes.
In following part, the detailed description of embodiments of the invention will be provided.The description of preferred and substituting embodiment is only exemplary embodiment, and it will be appreciated by those skilled in the art that variation, amendment and change can be apparent.Therefore, should be appreciated that described exemplary embodiment does not limit basic scope of invention.
vocabulary
Relevant with the present invention in the specification and claims, can use each term of giving a definition be suitable for:
Adhere to promotion: for representing, increase the process of adhering to trend of (for example,, between rigidity insert and encapsulation object) between 2 surfaces in this article.
Rear curved surface part or rear insert part: in this article for representing, the solid-state components of multi-block rigidity insert, in the time being assembled into described insert, it is by the position occupying on the dorsal part of ophthalmic lens.In Ophthalmoligic instrument, such part can be positioned in the more close wearer's of described insert a side on eye surface.In certain embodiments, described rear curved surface part can contain and be included in the central region of Ophthalmoligic instrument, and light can enter in wearer's eye through this region.This region can be known as visual area.In other embodiments, described part can circular in configuration, and wherein it does not contain or do not comprise some or all regions in visual area.In some embodiment of ophthalmology insert, can have multiple rear curved surface parts, and in them one can comprise visual area, and the part that other rear curved surface part can be annular or annulation.
Parts: for representing, can obtain the device of electric current with one or more variations of actuating logic state or physical state from the energy in this article.
Seal: in this article for representing, for example set up barrier, so that entity (, medium insert) is separated with the environment of contiguous described entity.
Encapsulation object: in this article for representing, the layer for example, around forming at entity (, medium insert), it sets up barrier so that described entity is separated with the environment of contiguous described entity.For example, encapsulation object can comprise silicone hydrogels, such as Etafilcon, Galyfilcon, Narafilcon and Senofilcon or other hydro-gel contact lens material.In certain embodiments, encapsulation object can be semipermeable to contain the material of appointment at described entity, and stops the material (for example, water) of specifying to enter described entity.
Energy supply: in this article for representing, can supply with electric current or can have the state of electric energy therein.
Energy: in this article for representing, the ability that allows physical system do work.Many application in the present invention can relate to the described ability that can carry out electro ultrafiltration in acting process.
The energy: for representing, can supply with energy or make the device of biologic medical equipment in energy supply state in this article.
Energy collecting device: in this article for representing, can extract energy from environment and be translated into the device of electric energy.
Front curve part or front insert part: in this article for representing, the solid-state components of multi-block rigidity insert, in the time being assembled into described insert, it is by the position occupying on the front side of ophthalmic lens.In Ophthalmoligic instrument, such part can be positioned in a side on the eye surface further from wearer of described insert.In certain embodiments, described part can contain and be included in the central region of Ophthalmoligic instrument, and light can enter in wearer's eye through this region.This region can be known as visual area.In other embodiments, described part can circular in configuration, and wherein it does not contain or do not comprise some or all regions in visual area.In some embodiment of ophthalmology insert, can have multiple front curve parts, and in them one can comprise visual area, and the part that other front curve part can be annular or annulation.
Form mixture or reactive mixture or the reactive monomer mixture (RMM) of eyeglass: the monomer or the prepolymer material that form in this article ophthalmic lens for representing, can be cured and be cross-linked maybe can be crosslinked.Various embodiment can comprise the mixture of the formation eyeglass that contains one or more additives, described additive for example ultraviolet interleaving agent, colouring agent, light trigger or catalyst and for example, in ophthalmic lens (haptic lens or intraocular lens) useful other additive.
Form the surface of eyeglass: in this article for representing, for the surface of molding ophthalmic lens.In certain embodiments, any such surface can have optical quality surface smoothness, this instruction, its smooth enough, and it is acceptable on optics that moulding makes ophthalmic lens surfaces, described ophthalmic lens surfaces is by the type that is polymerized of the mixture of the formation eyeglass that contacts with molded surface.In addition, in certain embodiments, form the surface of eyeglass and can there is the necessary geometry of optical quality of giving expectation to ophthalmic lens surfaces, include but not limited to spherical, the non-spherical and cylindricality number of degrees, wave-front aberration correction, the rectification of cornea topography etc., or their combination.
Lithium ion battery: in this article for representing such electrochemical cell: lithium ion moves to produce electric energy through described battery.This electrochemical cell that is commonly called battery can carry out reenergize or recharge with its canonical form.
Medium insert: in this article for representing, by the insert of sealing being comprised in energy supply Ophthalmoligic instrument.Can be by energy supply element and circuit embedding medium insert.Medium insert has determined the main application of energy supply Ophthalmoligic instrument.For example, allow user to regulate in the embodiment of eyesight ability at energy supply Ophthalmoligic instrument, described medium insert can comprise the energy supply element of controlling the liquid falcate part in visual area.Alternatively, medium insert can be annular, makes visual area not contain material.In such embodiments, the energy supply function of eyeglass can not be eyesight characteristic, but can be for example monitoring glucose or drug administration.
Mould: in this article for representing, can form for never curing preparation rigidity or the semi-rigid object of ophthalmic lens.Some preferred moulds comprise two mold components that form front curve mould and back curve mold.
Ophthalmic lens or Ophthalmoligic instrument or eyeglass: for representing, be installed in any device in inside ofeye or ocular surface in this article.Described device can provide optical correction, can be beauty treatment property, or functional that some and eyesight characteristic have nothing to do is provided.For example, term eyeglass can represent that haptic lens, intraocular lens, covering eyeglass, eyes insert, optics insert or other similarly install, it is for rectification or improve eyesight, or for strengthening eyes physiology (as iris color) and can not affect one's power of vision at aspect aspect beauty treatment.Alternatively, eyeglass can represent to be placed on the device for example, with function except vision correction (, the component of monitoring tear) in ocular surface or the device of administering active agents.In certain embodiments, preferred eyeglass of the present invention can be the soft contact lens sheet of being made up of elastomer silicone or hydrogel, and described hydrogel can comprise for example silicone hydrogels and fluorine hydrogel.
Visual area: in this article for representing such ophthalmic lens region: the wearer of ophthalmic lens can see through this region and watch.
Power: in this article for representing, the interior institute's work of time per unit or the energy transmitting.
Precuring: in this article for representing, the partly process of curing mixture.In certain embodiments, precuring process can comprise the complete solidification process of short time period.Alternatively, precuring process can comprise unique process, for example, by described mixture be exposed to from for solidifying different temperature and the optical wavelength of described material completely.
Pre-filled: in this article for representing, initial deposition material, its amount has been less than the complete amount that this process may be essential.For example, pre-filledly can comprise 1/4th of essential material.
Rear filling: in this article for representing, after pre-filled, deposited the material of the essential surplus of this process possibility.For example, in the case of pre-filled comprise essential material 1/4th, rear filling subsequently can provide remaining 3/4ths material.
Rechargeable or can reenergize: for representing, to return to the ability of the state with larger acting ability in this article.Many purposes in the present invention may make electric current relevant with the ability of the mobile state of given pace to returning to have in certain recovery time in section.
Recharge or reenergize: for representing, return to the action of the state with larger acting ability in this article.Many purposes in the present invention may make electric current relevant with the state of the mobile ability of given pace to device being returned to have in certain recovery time in section.
Discharge from mould: in this article for representing such action: wherein ophthalmic lens separates completely with mould, or just loosely is attached, make it can be by rocking gently to remove or releasing with swab.
Rigidity insert: for representing, maintain the insert of predefined pattern in this article.In the time being comprised in haptic lens, described rigidity insert can be facilitated the functional of eyeglass.For example, the pattern or the density that change rigidity insert can limit such region, and the eyesight of the user with astigmatic eyes can be corrected in described region.
Rock-steady structure: for representing, in the time that Ophthalmoligic instrument is placed on eyes, make Ophthalmoligic instrument stablize the physical characteristic to specific orientation on eyes in this article.In certain embodiments, described rock-steady structure can add enough quality with ballast Ophthalmoligic instrument.In certain embodiments, described rock-steady structure can change front curve surface, and wherein eyelid can be caught described rock-steady structure, and user can be by making nictation eyeglass redirect.By comprising the rock-steady structure that can add quality, can strengthen such embodiment.In some exemplary embodiment, rock-steady structure can be and the material of sealing biocompatible materials and separating, can be the insert forming from moulding process individually, or can be contained in rigidity insert or medium insert.
Stacking integrated component device (SIC-device): in this article for representing the product of such package technique: described technology, by means of at least a portion of each layer is stacking each other, can be assembled into work integrated device by the thin layer of substrate (it can contain electricity and electromechanical device).That described layer can comprise is dissimilar, the composition device of material, shape and size.In addition, described layer can be prepared by different device production technologies, to coordinate and to present different profiles.
inflatable index: in this article for representing, expansiveness or the inflationary spiral of certain material in the process of manufacturing ophthalmic lens.
ophthalmic lens
With reference to figure 1, explain an exemplary embodiment ophthalmic lens 100 that contains rigidity insert 110, wherein said rigidity insert 110 comprises the physical attribute of astigmatism eye patient's eyesight.In certain embodiments, rigidity insert 110 can reflect the astigmatic feature of eyes.For example, rigidity insert 110 can comprise: have the first area 111 at first refractive power and refraction angle, and have the second area 112 at the second refracting power and refraction angle.In certain embodiments, described first area 111 can inaccurately be positioned at the central authorities of eyes, and described second area 112 can not be radial symmetric.
In such embodiments, rock-steady structure 120 can be that ophthalmic lens 100 is suitably directed necessary on eyes.Rock-steady structure 120 can comprise and be different from the material of sealing reactive monomer mixture.In certain embodiments, can before placing rigidity insert 110, the material of rock-steady structure 120 be placed on front curve mold component.Alternatively, can, after rigidity insert 110 being placed between front curve mold component and back curve mold part, described material be injected in ophthalmic lens 100.
As shown at cross section, rock-steady structure 120 can be directed on eyes by ophthalmic lens 100 as follows: add enough quality with grappling ophthalmic lens 100, thereby prevent from rotating on eyes.In some alternate embodiment, rock-steady structure 110 can comprise the material with the inflatable index different from sealing RMM.In such embodiments, described rock-steady structure 110 can expand in the process that forms ophthalmic lens 100, and wherein said expansion allows rock-steady structure 110 to change the front surface pattern of ophthalmic lens 100.In the time being placed on eyes, eyelid can be caught rock-steady structure 110, and user can be by making nictation eyeglass redirect.For further convenient placement on eyes, rock-steady structure 110 can contain colouring agent, and wherein user can find out before placing ophthalmic lens 100 may how directed on eyes.
In certain embodiments, can be formed rigidity insert: lamella alignment and that keep is thermoformed into 3D shape, and described 3D shape can copy the surface of hot-forming die parts.Can cut the part obtaining from thin material lamella.Also surround described insert with reactive monomer mixture by rigidity insert being placed in the chamber being limited by front and rear curve mold part, can form ophthalmic lens.Cutting out from heat-formable material the process of insert part, alignment feature can be cut in insert part to such as indenture, groove or plane etc.These features can be for the ophthalmology insert device of align in processing afterwards insert part or formation.
With reference to figure 2, explain an alternate embodiment of the ophthalmic lens 200 with rigidity insert 210, wherein said rigidity insert 210 comprises the physical attribute of astigmatism patient's eyesight.Having in the patient of severe astigmatism eye, rigidity insert 210 can comprise the complex configuration in region 211-213, wherein the eyesight of the specific part of each region 211-213 correction oculars.Rigidity insert 210 can be encapsulated in ophthalmic lens 200 completely, and can directly not contact with eyes.Therefore, in certain embodiments, rigidity insert 210 can comprise multiple material, and wherein said material can not be biocompatible.For example, first area 211 can comprise the material different from second area 212 or the 3rd region 213.The performance of every kind of material can increase the validity of the vision correction in each region 211-213, or independent performance may be enough to astigmatism feature.Described performance can comprise for example density or refractive index.
In certain embodiments, can form rigidity insert 210 by hot forming process.For example, in the embodiment that comprises unique material in each region 211-213, can be with every kind of material coated sheet partly.The rigidity insert hot forming that can be cut into by thin slice or from thin slice is to comprise three-dimensional surface, and the 3 d surface topography of wherein said rigidity insert can be facilitated the rectification of the astigmatic feature of eyes.In certain embodiments, described three-dimensional surface can be enough to set up necessary region 211-213.
In some embodiment of ophthalmic lens 200 that comprises the rigidity insert 210 that contains multiple regions, and particularly in the situation that rigidity insert 210 comprises complicated variation, can comprise rock-steady structure 220 at rigidity insert 210.This may allow the Accurate align between rock-steady structure 220 and rigidity insert 210.Can, by hot formed rigidity insert 210 some specific embodiment, can be cut into rigidity insert to comprise rock-steady structure 220 from thin slice therein, as shown at cross section, wherein rock-steady structure 220 extends from rigidity insert 220.
Be similar to Fig. 1, rock-steady structure 220 can change front surface pattern, thus user can by nictation ophthalmic lens 200 is redirected, or, in certain embodiments, described rock-steady structure 220 can add enough quality so that ophthalmic lens 200 is directed on eyes.Some other embodiment can comprise the combination of the front surface pattern of quality and change.Rock-steady structure 220 can comprise further feature, and described further feature can assist user that ophthalmic lens 200 is suitably directed.For example, rock-steady structure 220 can comprise how mint-mark word or colouring agent can be placed on ophthalmic lens 200 on eyes with instruction user.
In certain embodiments, can comprise other passive element at rigidity insert 210.In certain embodiments, described rigidity insert 210 can comprise the polarizer that can reduce dazzle, and this can increase vision definition.In certain embodiments, described rigidity insert 210 can comprise can increase the cosmetology function printed patterns of (comprising the hidden of region 211-213 on rigidity insert 210).In certain embodiments, described rigidity insert 210 can comprise soluble activating agent in the time that ophthalmic lens 200 is placed on eyes.At astigmatic eyes, by the damage of eyes is caused, the embodiment that wherein said activating agent is medicine can be particular importance.
With reference to figure 3, explain the exemplary procedure of processing that is used to form the ophthalmic lens 309 that contains rigidity insert 304, wherein said rigidity insert 304 is encapsulated, and can astigmatism eyesight.Comprised exemplary material and curing specification at table 1, but other material and polymerization technique can be apparent, and in the scope of described invention field.310, can give the pre-filled reactive monomer mixture 303 of front curve mould 301.In certain embodiments, can rock-steady structure 302 be placed on front curve mould 301 or be placed on pre-filled RMM303.
320, rigidity insert 304 can be disposed adjacent to front curve mould 304 and contact with pre-filled RMM, wherein said placement can form front curve assembly 301-304.In the embodiment that rock-steady structure 302 separates with rigidity insert 304 therein, can make rigidity insert 304 align with rock-steady structure 302, and be placed to, in the time that ophthalmic lens 309 is placed on eyes, allow the suitable orientation of ophthalmic lens 309.
330, can give the rear filling reactive monomer of front curve assembly 301-304 mixture 305, wherein said pre-filled amount 303 and described rear loading 305 can be sealed rigidity insert 304 completely and suitably form ophthalmic lens 308.340, back curve mold 306 can be disposed adjacent to front curve mould 301, wherein said front curve mould 301 and described back curve mold 306 can form eyeglass and form chamber 308.Described eyeglass forms chamber 308 can combine the RMM305 of rear filling and pre-filled RMM303, and this can allow RMM307 to seal rigidity insert 304 completely.
In certain embodiments, described RMM307 can be attached to or seal at least in part rock-steady structure 303.Can polymerization front curve and rear curved surface assembly 301-307, for example, by solidification process, to form ophthalmic lens 309.350, can take out ophthalmic lens 309 from mold apparatus 301,306.
the part list of exemplary encapsulant, encapsulating material and the coating material of table 1 one
Element can be formed by such material: it is stable that described material can yes or no in the residing environment of Ophthalmoligic instrument, and described environment comprises, for example, tear in the ocular surface contacting with described element.Described application can comprise from coating formation encapsulated layer, comprise that for example Parylene family includes but not limited to Parylene C, N and D family element.In certain embodiments, described in, seal before or after coating can occur in and apply other adhesive or sealant layer.
the method of the ophthalmic lens based on insert and material
Go back with reference to figure 3, explained the exemplary procedure of processing that is used to form the ophthalmic lens 309 that contains rigidity insert 304, wherein said rigidity insert 304 is encapsulated and may can astigmatism eyesight.Die apparatus 301,306 used herein can comprise the plastics that form for eyeglass formation chamber 308 is shaped, form in chamber 308 and can distribute the mixture 307 that forms eyeglass at described eyeglass, and form eyeglass mixture 307 reaction or solidify after, produce the ophthalmic lens 309 of shape with expectation.The combinatorial optimization ground of mold component 301,306 is temporary transient, wherein, after ophthalmic lens 309 forms, can in 350, mold component 301,306 be separated to take out ophthalmic lens 309.
Surperficial at least a portion of at least one mold component 301,306 can contact with the mixture 307 that forms eyeglass, make form eyeglass mixture 307 reaction or solidify after, described surface provides shape and the form of expectation to the part contacting with it of ophthalmic lens.This is applicable at least one other mold component 301,306.
Thereby, for example, in one exemplary embodiment, die apparatus 301,306 is formed by 2 parts 301,306: female sunk part (front curve mould) 301 and male projection (back curve mold) 306, form chamber 308 between the two at them.The part that the mixture 307 with forming eyeglass of sunk surface contacts has the curvature of the front curve of ophthalmic lens 309.
Described part is smooth enough, and moulding to make the surface of ophthalmic lens 309 be acceptable on optics, described ophthalmic lens 309 forms by the polymerization of the mixture 307 of the formation eyeglass that contacts with sunk surface.In certain embodiments, described front curve mould 301 also can have annular flange flange, described flange and annular circumferential edge become one and surround described annular circumferential edge, and described annular circumferential edge the past curve mold 301 in the plane vertical with axis is stretched out and also stretches out (not shown) from flange.
The surface that forms eyeglass can comprise the surface with optical quality surface smoothness, this instruction, it is smooth enough, and it is acceptable on optics that moulding makes ophthalmic lens surfaces, described ophthalmic lens surfaces is by the shape that is polymerized of the mixture 308 of the formation eyeglass that contacts with molded surface.In addition, in certain embodiments, the surface of the formation eyeglass of mold component 301,306 can have the necessary geometry of optical quality of giving expectation to ophthalmic lens surfaces, includes but not limited to spherical, non-spherical and the cylindricality number of degrees, wave-front aberration correction, the rectification of cornea topography and their combination.Those of ordinary skill in the art will appreciate that, except discuss those feature also can be included within the scope of the present invention.
Some extra embodiment comprise the rigidity insert 304 that can be encapsulated in completely in hydrogel matrix.For example, use microinjection molding technology, can manufacture rigidity insert 304.Embodiment can comprise, for example, poly-(4-methylpent-1-alkene) copolymer resin, it has the central thickness between the front surface radius between diameter, the about 6mm to 10mm of about 6mm to 10mm, rear surface radius and the about 0.050mm to 0.5mm between about 6mm to 10mm.Some exemplary embodiments comprise such insert: it has the edge contour of the central thickness of the rear surface radius of the front surface radius of the diameter of about 8.9mm, about 7.9mm, about 7.8mm, about 0.100mm and approximately 0.050 radius.The five tons of systems of Microsystem50 that provided by Battenfield Inc. can be provided a kind of exemplary micro-mould machine.Some or all of seal feature (including but not limited to groove, seam, lip and knife-edge edge) can form in moulding process, or the following process of the result by moulding process forms afterwards.
Rigidity insert 304 can be put into the mold component 301,306 that is used to form ophthalmic lens 308.Mold component 301,306 materials can comprise, for example, below one or more polyolefin: the polyolefin of polypropylene, polystyrene, polyethylene, polymethyl methacrylate and modification.Other mould can comprise pottery or metal material.
Can comprise with other mold materials that forms ophthalmic lens mold with one or more additive combinations, for example, Zieglar-Natta acrylic resin (being sometimes known as znPP); Purification random copolymer according to FDA regulations 21CFR (c) 3.2 for clean molding; The random copolymer (znPP) that contains ethylidene.
Further, in certain embodiments, mould of the present invention can contain polymer such as polypropylene, polyethylene, polystyrene, polymethyl methacrylate, the improved polyalkene that contains alicyclic part in main chain and cyclic polyolefin.This admixture can use in any mold half or two mold half.Preferably, this admixture uses on rear curved surface, and front curve is made up of alicyclic co-polymer.
In some method for optimizing of mould 300 constructed in accordance, injection-molded according to known utilization.Embodiment can also comprise the mould being shaped by other technology, and described other technology comprises, for example lath pressure, rhombus rotation or laser cutting.
Conventionally, at least one surface of mold component 301 and 302, form ophthalmic lens.But, in certain embodiments, can form a surface of ophthalmic lens from mold component 301 and 302, and can for example use lath platen press to form another surface of ophthalmic lens.
In certain embodiments, ophthalmic lens type can comprise the ophthalmic lens comprising containing organosilyl component.The component that contains at least one [Si-O-] unit in monomer, macromonomer or prepolymer containing organosilyl component.Preferably, the oxygen of all organosilicons and connection is present in containing in organosilyl component with following amount: being greater than approximately 20 % by weight and being more preferably greater than 30 % by weight containing the total molecular weight of organosilyl component.Useful preferably comprises polymerisable functional group such as acrylate, methacrylate, acrylamide, Methacrylamide, vinyl, N-vinyl lactam, N-vinylamide and styryl functional group containing organosilyl component.
In certain embodiments, ophthalmic lens edge (also referred to as the insert encapsulated layer that surrounds insert) can comprise the hydrogel ophthalmology eyeglass preparation of standard.Have can provide with the exemplary materials of the feature of accepting to mate of numerous insert materials and can include but not limited to Narafilcon family (comprising Narafilcon A and Narafilcon B) and Etafilcon family (comprising Etafilcon A).The character of consistent in the art material is depended in the more discussion of inclusive technically.Those of ordinary skill in the art can recognize, except discuss those other material also can form sealing and acceptable shell insert that seal or part shell, and should regard as consistent with the scope of claim and be included within the scope of the claims.
The suitable compound that comprises formula I containing organosilyl component
Wherein R
1independently selected from unit price reactive group, monovalent alkyl or unit price aryl, wherein any can also comprise and be selected from following functional group: hydroxyl, amino, oxa-, carboxyl, alkyl carboxyl, alkoxyl, acylamino-, carbamate, carbonic ester, halogen or their combination; The monovalent siloxane chain that comprises 1-100 Si-O repetitives, described Si-O repetitive can also comprise and is selected from following functional group: alkyl, hydroxyl, amino, oxa-, carboxyl, alkyl carboxyl, alkoxyl, acylamino-, carbamate, halogen or their combination;
Wherein b is 0-500, wherein should be appreciated that, in the time that b is not 0, b seems to have the distribution of the pattern that equals described value;
Wherein at least one R
1comprise unit price reactive group, and in certain embodiments, 1-3 R
1comprise unit price reactive group.
Unit price reactive group used herein is the group that can experience radical polymerization and/or cationic polymerization.The non-limitative example of radical reaction group comprises: (methyl) acrylate, styryl, vinyl, vinyl ethers, C
1-6alkyl (methyl) acrylate, (methyl) acrylamide, C
1-6alkyl (methyl) acrylamide, N-vinyl lactam, N-vinylamide, C
2-12thiazolinyl, C
2-12thiazolinyl phenyl, C
2-12thiazolinyl naphthyl, C
2-6thiazolinyl phenyl C
1-6alkyl, O-vinyl carbamate and O-vinyl carbonic ester.The non-limitative example of cationoid reaction group comprises: vinyl ethers or epoxide group and composition thereof.In one embodiment, described radical reaction group comprise (methyl) acrylate, propenyloxy group, (methyl) acrylamide, and composition thereof.
Suitable monovalent alkyl and aryl comprise unsubstituted unit price C
1-16alkyl, C
6-14aryl, such as substituted and unsubstituted methyl, ethyl, propyl group, butyl, 2-hydroxypropyl, propoxyl group propyl group, polyethyleneoxy propyl group, their combination etc.
In one embodiment, b is 0, one R
1unit price reactive group, and at least 3 R
1be selected from the monovalent alkyl with 1-16 carbon atoms, or, in another embodiment, be selected from the monovalent alkyl with 1-6 carbon atoms.The non-limitative example of the organosilicon component of this embodiment comprises:
2-methyl-, 2-hydroxyl-3-[3-[1,3,3,3-tetramethyl-1-[(trimethyl silyl) oxygen base] disiloxane base] propoxyl group] propyl diester (" SiGMA "),
2-hydroxy-3-methyl acrylic oxygen base propoxyl group propyl group-tri-(trimethylsiloxy group) silane,
3-methylpropenyl oxygen base propyl group three (trimethylsiloxy group) silane (" TRIS "),
Two (trimethylsiloxy group) methyl-monosilanes of 3-methylpropenyl oxygen base propyl group, and
3-methylpropenyl oxygen base propyl group pentamethyl disiloxane.
In another embodiment, b is 2-20,3-15, or, in certain embodiments, 3-10; At least one end R
1comprise unit price reactive group, and remaining R
1be selected from the monovalent alkyl with 1-16 carbon atoms, or, in another embodiment, be selected from the monovalent alkyl with 1-6 carbon atoms.In another embodiment, b is 3-15, one end R
1comprise unit price reactive group, other end R
1comprise the monovalent alkyl with 1-6 carbon atoms, and remaining R
1comprise the monovalent alkyl with 1-3 carbon atoms.The non-limitative example of the organosilicon component of this embodiment comprises (dimethyl silicone polymer (400-1000MW) of list-(2-hydroxy-3-methyl acrylic oxygen base propyl group)-propyl ether end-blocking) (" OH-mPDMS ") and monomethyl acrylic oxygen base propyl group dimethyl silicone polymer end-blocking, single normal-butyl end-blocking (800-1000MW) (mPDMS).
In another embodiment, b is 5-400 or 10-300, two end R
1comprise unit price reactive group, and remaining R
1independently selected from the monovalent alkyl with 1-18 carbon atoms, its ether that can have between carbon atom connects, and can also comprise halogen.
In one embodiment, the in the situation that of needs silicone hydrogels ophthalmic lens, ophthalmic lens of the present invention is made up of such reactive mixture: based on the gross weight of reactive monomer component of the described polymer of preparation, its comprise at least about 20 % by weight and preferably approximately 20-70 % by weight containing organosilyl component.
In another embodiment, 1-4 R
1the ethylene carbonate of contained II or carbamic acid ethene ester
Wherein Y represents O-, S-or NH-; And R represents hydrogen or methyl; D is 1,2,3 or 4; And q is 0 or 1.
Comprise particularly 1,3-bis-[4-(vinyl oxygen base carbon acyloxy) fourth-1-yl] tetramethyl-disiloxane containing organosilyl ethylene carbonate or carbamic acid vinyl acetate monomer; 3-(vinyl oxygen base phosphinylidyne sulfenyl) propyl group-[three (trimethylsiloxy group) silane]; Carbamic acid-3-[tri-(trimethylsiloxy group) silicyl] propyl group allyl ester; Carbamic acid-3-[tri-(trimethylsiloxy group) silicyl] propyl ethylene ester; Carbonic acid trimethyl silyl ethylethylene ester; Carbonic acid trimethyl silyl ethylene methacrylic ester, and
In the case of need to be lower than the biologic medical equipment of about 200 modulus, an only R
1comprise unit price reactive group, and remaining R
1being no more than 2 and comprising monovalent siloxane group in group.
The another kind of polyurethane macromolecular monomer that comprises following formula containing organosilyl component:
Formula IV--VI
(*D*A*D*G)
a*D*D*E
1；
E (* D*G*D*A)
a* D*G*D*E
1or;
E(*D*A*D*G)
a*D*A*D*E
1
Wherein D represents alkyl residue of divalent, alkyl-cycloalkyl residue of divalent, cycloalkyl residue of divalent, aryl residue of divalent or alkylaryl residue of divalent, and it has 6-30 carbon atom;
Wherein G represents alkyl residue of divalent, cycloalkyl residue of divalent, alkyl-cycloalkyl residue of divalent, aryl residue of divalent or alkylaryl residue of divalent, and it has 1-40 carbon atom, and it can contain ether, sulfo-or amine connection in main chain;
* represent that carbamate or urea groups connect;
aat least 1; And
A represents the divalence polymeric residues of following formula:
wherein R
11represent independently to have the alkyl of 1-10 carbon atoms or the alkyl that fluorine replaces, it can contain the ehter bond between carbon atom; Y is at least 1; And p provides 400-10,000 part weight; E and E
1in each polymerisable undersaturated organic residue of being represented by formula VIII of representing independently
Wherein R
12hydrogen or methyl; R
13be hydrogen, the alkyl residue with 1-6 carbon atoms or-CO-y-R
15residue, wherein Y be-O-, Y-S-or-NH-; R
14it is the residue of divalent with 1-12 carbon atoms; Represent-CO-of X or-OCO-; Represent-O-of Z or-NH-; A
rrepresent to have the aromatic moieties of 6-30 carbon atom; W is 0-6; X is 0 or 1; Y is 0 or 1; And z is 0 or 1.
Preferred is the polyurethane macromolecular monomer (by connecting corresponding asterisk region * to *, * * to a * *, being appreciated that its complete structure) being represented by formula IX containing organosilyl component
Wherein R
16the residue of divalent of removing the later vulcabond of NCO, such as the residue of divalent of IPDI.Another kind of suitable be the compound (wherein x+y is the numeral in the scope of 10-30) of the formula X that forms by the reaction of fluoro-ether, hydroxy-end capped dimethyl silicone polymer, IPDI and methacrylic acid isocyano group ethyl ester containing organosilyl macromonomer.
Formula X (by connecting corresponding asterisk region * to *, being appreciated that its complete structure)
Being suitable for use in other in the present invention comprises containing organosilyl component: containing the macromonomer of polysiloxane, polyalkylene ether, vulcabond, poly-fluorohydrocarbon, poly-fluoro-ether and polysaccharide group; Polysiloxanes, it has grafting or the side group of the fluoro of polarity, and described side group has the hydrogen atom being connected with the carbon atom of end difluoro replacement; Hydrophilic methacrylic acid silicone esters, it contains ether is connected and contains polyethers and polysiloxane group crosslinkable monomers with siloxy group.Any in aforementioned polysiloxanes can also be in the present invention as containing organosilyl component.
mould journey
The example of the process that following method step can realize as some aspect according to the present invention is provided.Should be appreciated that the order that described method step occurs and do not mean that restrictively, and can realize the present invention with other order.In addition, not need all steps could realize the present invention, can comprise additional step in different embodiments of the invention.Those skilled in the art can be apparent, and extra embodiment can be practical, and such method belongs in the scope of claim completely.
With reference now to Fig. 4,, flow chart has been explained can be for realizing illustrative steps of the present invention.Run through described process, before the step that uses the parts that contain plastics realizes, can be by degassed the parts containing plastics.Degassed can removing may be suppressed polymerization or be caused other defect of lens gas of (comprising gr defect, such as hole or hole), such as oxygen or dissolved gas.
405, can form rigidity insert, the specific astigmatic feature that it can correction ocular.Described rigidity insert can comprise multiple regions, wherein the eyesight of the specific part of each region astigmatism eyes.Comprising into before in moulding process, can carry out plasma cleaning to described rigidity insert.
410, can process described rigidity insert, to increase described rigidity insert to the trend of adhering to of sealing reactive monomer mixture.In certain embodiments, the formation of described rigidity insert can comprise that adhering to promotion processes.Can promote the trend of adhering between RMM and rigidity insert by vapour deposition, wherein described rigidity insert is exposed to and adhere to promotion chemical reagent, and be stored in vacuum chamber simultaneously.
412, front curve mould recess side up can be put into support plate, described support plate comprises, for example pallet.415, can give the pre-filled reactive monomer mixture of front curve mould.Can optimize pre-filled amount and position, suitably seal rigidity insert with the ophthalmic lens of guaranteeing to obtain.For example, very few pre-filled RMM may stop completely and seals, and too much pre-filled RMM may cause bubble to form in eyeglass forms chamber.In some preferred embodiment, pre-filled amount can be about 10uL RMM.Similarly, the pre-filled placement relevant with rigidity insert can reduce the problem of sealing.For example, pre-filled placement on front curve mould can with rigidity insert on steepest depression points overlapping.
In certain embodiments, described molding step 415-445 can carry out in rich nitrogen environment, preferably has 0.0% to 0.5% oxygen content.Therefore,, before using, can make the parts and the environmental balance that in whole process, use.
In certain embodiments, 417, rock-steady structure can be disposed adjacent to front curve mould.In some such embodiment, rock-steady structure directly can be placed or is deposited on front curve mould.In other embodiments, rock-steady structure can be placed or is deposited on pre-filled RMM.Rock-steady structure can be placed on to definite position, to allow and rigidity insert Accurate align.In other embodiments, after filling front curve mould completely, can comprise rock-steady structure at ophthalmic lens.In such embodiments, rock-steady structure can be injected to ad-hoc location suitably to align with rigidity insert.
420, rigidity insert can be disposed adjacent to front curve mould and contact with pre-filled RMM, wherein said placement forms front curve assembly.In certain embodiments, 415 pre-filled before, rigidity insert can be arranged near front curve mould.In such embodiments, after 415 pre-filled step, rigidity insert can be embedded in front curve mould.Therein rock-steady structure is included in the embodiment in rigidity insert, described placement rigidity insert may not need to special alignment on front curve mould.The alternate embodiment that wherein comprises dividually rock-steady structure and rigidity insert in ophthalmic lens may need the special alignment between rigidity insert and front curve mould (or more specifically, rock-steady structure).
In some preferred embodiment, 420, can place rigidity insert via machinery.Machinery placement can comprise, for example, and robot or other automatic operation are for example, known for placement surface installing component or pick up and put those of automation equipment in industry.The people of rigidity insert places also within the scope of the present invention.Therefore, in the following cases, mechanical placement can be effective: rigidity insert is put into mold component by it, makes the polymerization of the reactive mixture that mold component comprises to comprise rigidity insert at the ophthalmic lens obtaining.
In certain embodiments, 425, can be by RMM precuring, to fix rigidity insert for remaining encapsulation process.For example, can be under blue cure lamp at 5mW in environment temperature (such as 22 DEG C) by front curve assembly precuring 2 minutes.Some alternate embodiments may be carried out multiple encapsulation step simultaneously.In such embodiments, may be optional in 425 pre-cure step.
430, can give after front curve assembly and fill remaining RMM, described RMM may be seal rigidity insert completely and produce ophthalmic lens necessary.435, back curve mold can be disposed adjacent to front curve assembly, wherein said placement meeting forms chamber between back curve mold and front curve mould.Described eyeglass formation chamber can limit the shape of ophthalmic lens, and described RMM can be encapsulated in the rigidity insert in chamber completely.
In certain embodiments, 440, can be by front curve assembly and the extremely degree of possibility reinforcing elements of rear curved surface assembly precuring.Precuring 440 may prevent migration or the inclination of the parts of front and rear curved element in complete solidification process.Described precuring can be the short process occurring soon after the structure completely of front curve assembly and rear curved surface assembly.
445, can make front curve assembly and rear curved surface assembly completely curing.Can make the reactive monomer polymerization of mixtures in chamber.For example, by be exposed to actinic radiation and hanker one or both, can complete polymerization.The parameter of solidification process can be determined by the concrete chemical property of RMM and rigidity insert.For example, may solidify RMM to the exposure of radiation, but the integrality of rigidity insert may be degraded or affect to described radiation.In certain embodiments, can extend hardening time, to allow permissible condition of cure.
450, can be by front curve assembly and the demoulding of rear curved surface assembly.In certain embodiments, 450, by front curve mould is separated with back curve mold, can be by front curve assembly and the demoulding of rear curved surface assembly.Some embodiment may be from described assembly tractive front curve mould, and other embodiment may be from described assembly tractive back curve mold, and other embodiment tractive front curve mould and back curve mold simultaneously.Be subject to the mould of tractive can determine how to take out ophthalmic lens from the assembly of the demoulding.
455, can take out the ophthalmic lens that contains rigid lens from the front curve assembly of the demoulding and rear curved surface assembly.After the demoulding, ophthalmic lens can keep being attached to front curve mould or back curve mold.In certain embodiments, described ophthalmic lens can be retained on mold component, and described mold component is not subject to tractive in 450 knockout course.
In certain embodiments, can operate the mold component that comprises ophthalmic lens to discharge described ophthalmic lens.Described operation can comprise, for example, and bending mould parts, and may allow more easily taking out of ophthalmic lens.In certain embodiments, can shake the mold component that comprises ophthalmic lens.For example, in mold component and ophthalmic lens are immersed in to solution (, controlled-temperature bath) time, can occur in 455 taking-up process.Ophthalmic lens and mold component are immersed in the aqueous solution and can allow ophthalmic lens partly to expand, and this may promote to take out from mold component.
Ophthalmic lens is retained in the embodiment on front curve mould therein, and the taking-up of ophthalmic lens may need additional step.For example, can be at edge's injection solution of eyeglass, so that ophthalmic lens rises on the surface of curve mold in the past.
460, can be by ophthalmic lens hydration.Hydro-combination process 460 can allow ophthalmic lens compatible with eyes, may depend on described compatibility comprising the functional of ophthalmic lens of rigidity insert.In certain embodiments, described hydro-combination process can comprise multiple stages, to guarantee the suitable expansion of ophthalmic lens.For example, the first stage can comprise: by ophthalmic lens in 50 DEG C are immersed in containing the solution of 0.45% Boratex of having an appointment 1 hour.Second stage can repeat by fresh solution the condition of first stage.The 3rd and terminal stage can comprise: by ophthalmic lens in soaking at room temperature in solution.
465, ophthalmic lens can be packaged in closed container.Described closed container can prevent from being exposed to air, and can comprise that solution is dry before use to prevent ophthalmic lens.
Although the present invention can be for providing by any known ophthalmic lens material or being suitable for manufacturing the hard or soft contact lens sheet that the material of such ophthalmic lens is made, preferably, ophthalmic lens of the present invention is the soft contact lens sheet with the water content of about 0-90%.More preferably, described ophthalmic lens is made up of one or both the monomer that containing in hydroxyl and carboxyl, or by making containing organosilyl polymer (such as siloxanes, hydrogel, silicone hydrogels and their combination).By making macromonomer, monomer and their the combination admixture reaction together with additive (such as polymerization initiator), can make the material that can be used for forming ophthalmic lens of the present invention.Suitable material includes but not limited to, the silicone hydrogels of being made up of silicone macromolecule monomer and hydrophilic monomer.
equipment
With reference now to Fig. 5,, explain an embodiment 500 of automation equipment 510, it has one or more inserts 514 and shifts interface 511.As explain, on pallet 512, contain multiple mold components, each mold component has relevant insert 514, and be pass medium shift interface 511.Embodiment can comprise individual interface or multiple interface (not shown), described individual interface is individually placed rigidity insert 514, described multiple interface is put into multiple mold components by rigidity insert 514 simultaneously, and in certain embodiments, puts into each mould.
Another aspect of some embodiment comprises that equipment supports rigidity insert 514, and the main body of ophthalmic lens is molded into around these parts.Can be by support point and by attached the polymeric material that is formed on the same type in ophthalmic lens main body.
conclusion
As mentioned above and as the further definition of claim below, the invention provides the method that is used to form the ophthalmic lens of sealing rigidity insert, wherein can customize the specific astigmatic feature of described rigidity insert with correction ocular, and equipment for realizing such method and the ophthalmic lens that contains rigidity insert of formation are provided.
Claims (17)
1. a method for the ophthalmic lens that formation contains rigidity insert, described method comprises:
With the next pre-filled front curve mold component of reactive monomer mixture;
Described rigidity insert is placed on described reactive monomer mixture;
Make the precuring of described reactive monomer mixture, to keep securely the contiguous described front curve mould of described rigidity insert, wherein said precuring meeting forms front curve assembly;
After coming with described reactive monomer mixture, fill described front curve assembly, wherein said amount pre-filled and described rear filling can be sealed described rigidity insert;
Contiguous described front curve assembly is placed described back curve mold part, and wherein said placement can form front curve and rear curved surface assembly;
Make described reactive monomer mixture solidified to form ophthalmic lens;
Make described front curve and the demoulding of rear curved surface assembly;
From the front curve of the described demoulding and rear curved surface assembly, shift out described ophthalmic lens; And
By described ophthalmic lens hydration.
2. method according to claim 1, the surface of wherein said rigidity insert comprises adhesion promoting layer.
3. method according to claim 1, comprises the following steps: in addition
At least one in described rigidity insert, described reactive monomer mixture, described front curve mould and described back curve mold is degassed, and wherein said degassed meeting removes the gas that can cause defect of lens.
4. method according to claim 1, comprises the following steps: in addition
Make the precuring of described reactive monomer mixture, to keep securely the contiguous described front curve assembly of described back curve mold.
5. method according to claim 1, the step of wherein said formation front curve assembly is carried out by automation equipment.
6. method according to claim 1, the reactive monomer mixture of wherein said polymerization comprises hydrogel.
7. method according to claim 6, wherein said hydrogel comprises silicone hydrogels.
8. method according to claim 4 wherein forms multiple ophthalmic lens that contain rigidity insert on pallet simultaneously.
9. method according to claim 1, wherein said rigidity insert can astigmatism eyesight.
10. method according to claim 9, wherein said rigidity insert comprises hot formed material.
11. methods according to claim 9, also comprise:
Rock-steady structure is joined in described reactive monomer mixture, and wherein said rock-steady structure can make ophthalmic lens directed on eyes;
Described rock-steady structure is alignd with described rigidity insert, and wherein said alignment allows astigmatism eyesight in the time that described ophthalmic lens is directed on eyes.
12. methods according to claim 11, wherein said rigidity insert comprises rock-steady structure.
13. methods according to claim 1, wherein said hydration also comprises following method step:
At the temperature of approximately 50 DEG C, described ophthalmic lens is immersed in the solution that comprises about 0.45% Boratex at least 1 hour.
14. methods according to claim 11, wherein said rock-steady structure is injectable material, described injectable material comprises the inflatable index different from described reactive monomer mixture.
15. methods according to claim 11, the wherein said front curve surface that adds rock-steady structure can change described ophthalmic lens.
16. methods according to claim 11, the wherein said rock-steady structure that adds can increase quality to described ophthalmic lens, and wherein said quality is enough to make described ophthalmic lens directed on eyes.
17. methods according to claim 11, wherein said rock-steady structure comprises visual orientation mark, and wherein said visual orientation mark comprises visible painted or mark.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/833,553 US9581832B2 (en) | 2013-03-15 | 2013-03-15 | Method and apparatus for encapsulating a rigid insert in a contact lens for correcting vision in astigmatic patients |
| US13/833553 | 2013-03-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104044286A true CN104044286A (en) | 2014-09-17 |
| CN104044286B CN104044286B (en) | 2018-01-05 |
Family
ID=50272528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410096328.8A Active CN104044286B (en) | 2013-03-15 | 2014-03-14 | Method and apparatus rigid insert being encapsulated in the haptic lens of the eyesight for correcting astigmatism patient |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9581832B2 (en) |
| EP (1) | EP2778764B2 (en) |
| JP (1) | JP6425902B2 (en) |
| KR (1) | KR102184890B1 (en) |
| CN (1) | CN104044286B (en) |
| AU (1) | AU2014201552B2 (en) |
| BR (1) | BR102014006311B1 (en) |
| CA (1) | CA2846696C (en) |
| HK (1) | HK1202164A1 (en) |
| IL (1) | IL231365B (en) |
| RU (1) | RU2639785C2 (en) |
| SG (1) | SG10201400602PA (en) |
| TW (1) | TWI609775B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9475709B2 (en) | 2010-08-25 | 2016-10-25 | Lockheed Martin Corporation | Perforated graphene deionization or desalination |
| US10418143B2 (en) | 2015-08-05 | 2019-09-17 | Lockheed Martin Corporation | Perforatable sheets of graphene-based material |
| US9834809B2 (en) | 2014-02-28 | 2017-12-05 | Lockheed Martin Corporation | Syringe for obtaining nano-sized materials for selective assays and related methods of use |
| US10653824B2 (en) | 2012-05-25 | 2020-05-19 | Lockheed Martin Corporation | Two-dimensional materials and uses thereof |
| US9744617B2 (en) | 2014-01-31 | 2017-08-29 | Lockheed Martin Corporation | Methods for perforating multi-layer graphene through ion bombardment |
| US9610546B2 (en) | 2014-03-12 | 2017-04-04 | Lockheed Martin Corporation | Separation membranes formed from perforated graphene and methods for use thereof |
| WO2014164621A1 (en) | 2013-03-12 | 2014-10-09 | Lockheed Martin Corporation | Method for forming filter with uniform aperture size |
| US9572918B2 (en) | 2013-06-21 | 2017-02-21 | Lockheed Martin Corporation | Graphene-based filter for isolating a substance from blood |
| US9731437B2 (en) | 2013-11-22 | 2017-08-15 | Johnson & Johnson Vision Care, Inc. | Method of manufacturing hydrogel ophthalmic devices with electronic elements |
| KR20160142820A (en) | 2014-01-31 | 2016-12-13 | 록히드 마틴 코포레이션 | Perforating two-dimensional materials using broad ion field |
| AU2015210875A1 (en) | 2014-01-31 | 2016-09-15 | Lockheed Martin Corporation | Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer |
| AU2015229331A1 (en) | 2014-03-12 | 2016-10-27 | Lockheed Martin Corporation | Separation membranes formed from perforated graphene |
| WO2016036888A1 (en) | 2014-09-02 | 2016-03-10 | Lockheed Martin Corporation | Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same |
| JP5873584B1 (en) * | 2015-03-12 | 2016-03-01 | 株式会社ホプニック研究所 | Plastic lens manufacturing method, film positioning method |
| CA2994664A1 (en) | 2015-08-06 | 2017-02-09 | Lockheed Martin Corporation | Nanoparticle modification and perforation of graphene |
| WO2017180137A1 (en) | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Method for treating graphene sheets for large-scale transfer using free-float method |
| WO2017180134A1 (en) | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Methods for in vivo and in vitro use of graphene and other two-dimensional materials |
| SG11201809015WA (en) | 2016-04-14 | 2018-11-29 | Lockheed Corp | Two-dimensional membrane structures having flow passages |
| CA3020880A1 (en) | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Selective interfacial mitigation of graphene defects |
| WO2017180135A1 (en) | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Membranes with tunable selectivity |
| EP3443329A4 (en) | 2016-04-14 | 2020-04-08 | Lockheed Martin Corporation | Methods for in situ monitoring and control of defect formation or healing |
| US10139521B2 (en) * | 2016-04-20 | 2018-11-27 | Coopervision International Holding Company, Lp | Silicone elastomer-hydrogel hybrid contact lenses |
| HUE063725T2 (en) * | 2016-04-20 | 2024-01-28 | Coopervision Int Ltd | Silicone elastomer-silicone hydrogel hybrid contact lenses |
| TWI718469B (en) * | 2019-01-09 | 2021-02-11 | 優你康光學股份有限公司 | Mould and method for demolding contact lens |
| CN111483099B (en) * | 2019-01-25 | 2022-05-10 | 优你康光学股份有限公司 | Mold for demolding contact lenses and method thereof |
| KR20240046800A (en) * | 2021-08-31 | 2024-04-09 | 매직 립, 인코포레이티드 | Integrated optical components for head-mounted display devices |
| TW202402514A (en) * | 2022-05-09 | 2024-01-16 | 瑞士商愛爾康公司 | Method for making embedded hydrogel contact lenses |
| WO2024069483A1 (en) * | 2022-09-28 | 2024-04-04 | Alcon Inc. | System and method to manufacture a contact lens with an embedded element |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6217171B1 (en) * | 1998-05-26 | 2001-04-17 | Novartis Ag | Composite ophthamic lens |
| US20070057397A1 (en) * | 2005-09-12 | 2007-03-15 | Duis Donnie J | Devices and processes for performing degassing operations |
| US20080245747A1 (en) * | 2007-04-06 | 2008-10-09 | Kernick Edward R | Methods of degassing ophthalmic lens monomer mixtures |
| US20090218705A1 (en) * | 2008-02-28 | 2009-09-03 | Patterson Leah K | Methods and systems for processing silicone hydrogel ophthalmic lenses for improved lens transfer |
| US20120234453A1 (en) * | 2011-03-18 | 2012-09-20 | Pugh Randall B | Stacked integrated component media insert for an ophthalmic device |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166255A (en) † | 1976-06-14 | 1979-08-28 | Minnesota Mining And Manufacturing Company | Hybrid corneal contact lens |
| US5620720A (en) † | 1994-11-29 | 1997-04-15 | Allergan | Cast molding of intraocular lenses |
| US5849209A (en) * | 1995-03-31 | 1998-12-15 | Johnson & Johnson Vision Products, Inc. | Mold material made with additives |
| US5690865A (en) * | 1995-03-31 | 1997-11-25 | Johnson & Johnson Vision Products, Inc. | Mold material with additives |
| ES2195183T3 (en) * | 1996-12-20 | 2003-12-01 | Bausch & Lomb | MARKERS FOR TORICAS CONTACT LENSES. |
| JPH11174388A (en) * | 1997-12-12 | 1999-07-02 | Hoya Health Care Kk | Toric contact lens |
| US6250757B1 (en) † | 1999-12-15 | 2001-06-26 | Johnson & Johnson Vision Products, Inc. | Hybrid refractive birefringent multifocal ophthalmic lenses |
| JP2002006269A (en) * | 2000-06-22 | 2002-01-09 | Kuraray Co Ltd | Resin mold for manufacturing contact lens and method for manufacturing contact lens |
| BR0215812A (en) * | 2002-07-19 | 2005-04-26 | Johnson & Johnson Vision Care | Rotationally stabilized contact lenses |
| AU2003260369A1 (en) * | 2002-08-06 | 2004-02-25 | Novartis Ag | Contact lenses |
| EP1947501B1 (en) * | 2002-08-09 | 2012-04-25 | E-Vision, LLC | Electro-active contact lens system |
| US20040141150A1 (en) * | 2003-01-21 | 2004-07-22 | Roffman Jeffrey H. | Hybrid multifocal contact lenses |
| KR20050032574A (en) * | 2005-01-18 | 2005-04-07 | 존슨 앤드 존슨 비젼 케어, 인코포레이티드 | Rotationally stabilized contact lenses |
| CN103933614B (en) † | 2005-02-14 | 2016-03-02 | 庄臣及庄臣视力保护公司 | Comfortable ophthalmic device and manufacture method thereof |
| US20070284770A1 (en) * | 2006-06-07 | 2007-12-13 | Ansell Scott F | Decreased lens delamination during ophthalmic lens manufacture |
| US7960465B2 (en) * | 2006-06-30 | 2011-06-14 | Johnson & Johnson Vision Care, Inc. | Antimicrobial lenses, processes to prepare them and methods of their use |
| US7883207B2 (en) * | 2007-12-14 | 2011-02-08 | Pixeloptics, Inc. | Refractive-diffractive multifocal lens |
| US20080290535A1 (en) * | 2007-05-24 | 2008-11-27 | Molock Jr Frank F | Reduction of excess polymeric flash ring |
| US8262952B2 (en) † | 2007-10-31 | 2012-09-11 | Bausch & Lomb Incorporated | Molds for production of ophthalmic devices |
| US7931832B2 (en) * | 2008-03-31 | 2011-04-26 | Johnson & Johnson Vision Care, Inc. | Ophthalmic lens media insert |
| US8922898B2 (en) † | 2008-09-04 | 2014-12-30 | Innovega Inc. | Molded lens with nanofilaments and related methods |
| US9296158B2 (en) * | 2008-09-22 | 2016-03-29 | Johnson & Johnson Vision Care, Inc. | Binder of energized components in an ophthalmic lens |
| EP2512777B1 (en) | 2009-12-14 | 2014-02-12 | Essilor International (Compagnie Générale D'Optique) | Process for producing a curved substrate covered with a film |
| US8814350B2 (en) * | 2012-02-13 | 2014-08-26 | Johnson & Johnson Vision Care, Inc. | Dynamic stabilization zones for contact lenses |
-
2013
- 2013-03-15 US US13/833,553 patent/US9581832B2/en active Active
-
2014
- 2014-03-06 IL IL231365A patent/IL231365B/en active IP Right Grant
- 2014-03-12 SG SG10201400602PA patent/SG10201400602PA/en unknown
- 2014-03-13 TW TW103108933A patent/TWI609775B/en not_active IP Right Cessation
- 2014-03-14 CA CA2846696A patent/CA2846696C/en active Active
- 2014-03-14 KR KR1020140030302A patent/KR102184890B1/en active IP Right Grant
- 2014-03-14 RU RU2014109968A patent/RU2639785C2/en active
- 2014-03-14 AU AU2014201552A patent/AU2014201552B2/en active Active
- 2014-03-14 CN CN201410096328.8A patent/CN104044286B/en active Active
- 2014-03-14 JP JP2014051279A patent/JP6425902B2/en active Active
- 2014-03-14 EP EP14160122.9A patent/EP2778764B2/en active Active
- 2014-03-17 BR BR102014006311-0A patent/BR102014006311B1/en active IP Right Grant
-
2015
- 2015-03-16 HK HK15102610.9A patent/HK1202164A1/en active IP Right Maintenance
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6217171B1 (en) * | 1998-05-26 | 2001-04-17 | Novartis Ag | Composite ophthamic lens |
| US20070057397A1 (en) * | 2005-09-12 | 2007-03-15 | Duis Donnie J | Devices and processes for performing degassing operations |
| US20080245747A1 (en) * | 2007-04-06 | 2008-10-09 | Kernick Edward R | Methods of degassing ophthalmic lens monomer mixtures |
| US20090218705A1 (en) * | 2008-02-28 | 2009-09-03 | Patterson Leah K | Methods and systems for processing silicone hydrogel ophthalmic lenses for improved lens transfer |
| US20120234453A1 (en) * | 2011-03-18 | 2012-09-20 | Pugh Randall B | Stacked integrated component media insert for an ophthalmic device |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014201552B2 (en) | 2017-12-21 |
| RU2639785C2 (en) | 2017-12-22 |
| US20140268020A1 (en) | 2014-09-18 |
| KR20140113535A (en) | 2014-09-24 |
| EP2778764B2 (en) | 2022-11-02 |
| CA2846696C (en) | 2021-01-26 |
| CA2846696A1 (en) | 2014-09-15 |
| IL231365B (en) | 2019-07-31 |
| AU2014201552A1 (en) | 2014-10-02 |
| JP6425902B2 (en) | 2018-11-21 |
| BR102014006311A2 (en) | 2014-12-23 |
| TW201501916A (en) | 2015-01-16 |
| SG10201400602PA (en) | 2014-10-30 |
| JP2014182393A (en) | 2014-09-29 |
| US9581832B2 (en) | 2017-02-28 |
| TWI609775B (en) | 2018-01-01 |
| RU2014109968A (en) | 2015-09-20 |
| IL231365A0 (en) | 2014-08-31 |
| CN104044286B (en) | 2018-01-05 |
| KR102184890B1 (en) | 2020-12-01 |
| BR102014006311B1 (en) | 2021-08-03 |
| EP2778764B1 (en) | 2019-11-20 |
| EP2778764A1 (en) | 2014-09-17 |
| HK1202164A1 (en) | 2015-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104044286A (en) | Method and apparatus for encapsulating rigid insert in contact lens for correcting vision in astigmatic patients | |
| CN104044239A (en) | Method And Apparatus For Encapsulating A Rigid Insert In A Contact Lens For Correcting Vision In Astigmatic Patients | |
| JP6505921B2 (en) | Sealing and Encapsulation in Energized Ophthalmic Device with Annular Insert | |
| RU2605419C2 (en) | Method for production of hydrogel ophthalmic devices with electronic elements | |
| CN103909666A (en) | Method of forming a multi-piece insert device with seal for ophthalmic devices | |
| CN102171028B (en) | Method and apparatus for forming a variable focus opthalmic device | |
| CN104049383A (en) | Sealing and encapsulation in energized ophthalmic devices with annular inserts | |
| CN103909665A (en) | Multi-piece insert device with glue seal for ophthalmic devices | |
| CN103909610A (en) | Multi-piece insert device with locking seal for ophthalmic devices | |
| CN102202874B (en) | Method for forming ophthalmic lens having energy source and electricity extraction element | |
| CN104044287A (en) | Patterned ophthalmic lenses with inserts | |
| CN104044283A (en) | Ophthalmic lenses with colorant patterned inserts | |
| CN104044285A (en) | Ophthalmic devices with stabilization features | |
| CN104142581A (en) | Ophthalmic devices with stabilization features |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |