CN104031056A - Production method of lycorine - Google Patents

Abstract

The invention provides a production method of lycorine. The production method comprises the following steps of S1, extracting lycoris squamigera maxim bulb powder, and refluxing and extracting for 2-24 hours by alcohol, filtering after cooling, taking filtrate and concentrating until the filtrate is dry; S2, concentrating to obtain residue, and dissolving the residue by hydrochloric acid with mass fraction of 1%-5%, filtering to obtain filtrate, and washing the filtrate by chloroform; and S3, adding soda ash and chloroform into the filtrate washed by the chloroform to extract, and separating out lycorine solids in the chloroform-alkaline water layer. The production method disclosed by the invention is simple to materials and not complex in equipment, and greatly lowers cost of lycorine production.

Description

A kind of production method of narcissine

Technical field

The present invention relates to the making method of narcissine, be specifically related to the method for utilizing pale reddish brown short-tube lycoris squama plant to carry out narcissine production.

Background technology

Narcissine has phlegm-dispelling functions, and heavy dose has emetic action, also has spasmolysis.Current narcissine is produced too complicated, with high costs.

Summary of the invention

The object of this invention is to provide a kind of production method of narcissine, solve one or more problem in above-mentioned prior art.

According to an aspect of the present invention, provide a kind of production method of narcissine, comprised the steps:

S1, get pale reddish brown short-tube lycoris bulb powder, with alcohol reflux 2～24h, cooled and filtered, gets filtrate and is concentrated into dry;

S2, to be concentrated into dry residue massfraction be 1%～5% dissolving with hydrochloric acid, crosses leaching filtrate, and filtrate is washed with chloroform;

Filtrate after S3, chloroform washing adds soda ash, and chloroform extraction is separated out narcissine solid in the middle of chloroform buck layer.

The production method of a kind of narcissine provided by the invention, raw material is simple, and equipment is uncomplicated, greatly reduces narcissine production cost.

In some embodiments, also comprise the following steps after S3:

HC with 1%～5% after S4, filter dissolves, concentrated, and crystallize out is dried to obtain narcissine hydrochloride.Be convenient to preservation and transport.

Embodiment

Embodiment 1:

The production method that the invention provides a kind of narcissine, comprises the steps:

S1, get pale reddish brown short-tube lycoris bulb powder, use alcohol reflux 2h, cooled and filtered, gets filtrate and is concentrated into dry;

S2, to be concentrated into dry residue massfraction be 1% dissolving with hydrochloric acid, crosses leaching filtrate, and filtrate is washed with chloroform;

Filtrate after S3, chloroform washing adds soda ash, and chloroform extraction is separated out narcissine solid in the middle of chloroform buck layer;

HC with 1% after S4, filter dissolves, concentrated, and crystallize out is dried to obtain narcissine hydrochloride.

Embodiment 2:

The production method that the invention provides a kind of narcissine, comprises the steps:

S1, get pale reddish brown short-tube lycoris bulb powder, use alcohol reflux 24h, cooled and filtered, gets filtrate and is concentrated into dry;

S2, to be concentrated into dry residue massfraction be 5% dissolving with hydrochloric acid, crosses leaching filtrate, and filtrate is washed with chloroform;

Filtrate after S3, chloroform washing adds soda ash, and chloroform extraction is separated out narcissine solid in the middle of chloroform buck layer;

HC with 5% after S4, filter dissolves, concentrated, and crystallize out is dried to obtain narcissine hydrochloride.

Embodiment 3:

The production method that the invention provides a kind of narcissine, comprises the steps:

S1, get pale reddish brown short-tube lycoris bulb powder, use alcohol reflux 12h, cooled and filtered, gets filtrate and is concentrated into dry;

S2, to be concentrated into dry residue massfraction be 2% dissolving with hydrochloric acid, crosses leaching filtrate, and filtrate is washed with chloroform;

Filtrate after S3, chloroform washing adds soda ash, and chloroform extraction is separated out narcissine solid in the middle of chloroform buck layer;

HC with 2% after S4, filter dissolves, concentrated, and crystallize out is dried to obtain narcissine hydrochloride.

More than statement is only optimal way of the present invention, it should be pointed out that to those skilled in the art, without departing from the concept of the premise of the invention, can also make some distortion and improvement, within these also should be considered as protection scope of the present invention.

Claims (2)

1. a production method for narcissine, is characterized in that, comprises the steps:

S1, get pale reddish brown short-tube lycoris bulb powder, with alcohol reflux 2～24h, cooled and filtered, gets filtrate and is concentrated into dry;

S2, to be concentrated into dry residue massfraction be 1%～5% dissolving with hydrochloric acid, crosses leaching filtrate, and filtrate is washed with chloroform;

Filtrate after S3, chloroform washing adds soda ash, and chloroform extraction is separated out narcissine solid in the middle of chloroform buck layer.

2. the production method of a kind of narcissine according to claim 1, is characterized in that, also comprises the following steps after S3:

HC with 1%～5% after S4, filter dissolves, concentrated, and crystallize out is dried to obtain narcissine hydrochloride.