CN104031026A - O-formylamino benzamide derivatives containing N-cyano sulfone(sulfur)imine, preparation method thereof and uses thereof - Google Patents

O-formylamino benzamide derivatives containing N-cyano sulfone(sulfur)imine, preparation method thereof and uses thereof Download PDF

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CN104031026A
CN104031026A CN201410081794.9A CN201410081794A CN104031026A CN 104031026 A CN104031026 A CN 104031026A CN 201410081794 A CN201410081794 A CN 201410081794A CN 104031026 A CN104031026 A CN 104031026A
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methyl
chloropyridine
agent
pyrazoles
formyl
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CN104031026B (en
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范志金
华学文
陈旭艳
毛武涛
陈晓燕
梁小文
刘细平
姬晓恬
李娟娟
宗广宁
李凤云
李岳东
房震
王曙华
周立峰
黄亮文
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JIANGXI TIANREN ECOLOGY CO Ltd
Nankai University
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JIANGXI TIANREN ECOLOGY CO Ltd
Nankai University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides

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Abstract

The invention provides o-formylamino benzamide derivatives containing N-cyano sulfone(sulfur)imine, a preparation method thereof and uses thereof. The invention relates to bisamide derivatives containing pyrazolecarboxamide, and the general chemical formula of the derivatives is shown as the formula I. The invention discloses a general structural formula and synthesis methods of the compounds, uses of the compounds serving as insecticides, bactericides, plant virus resisting agents and plant activators, and processing processes for the compounds in the preparation of the insecticides, the bactericides, the plant virus resisting agents and the plant activators in a manner of being mixed with agriculturally-acceptable assistants or synergists. The invention further discloses uses of combination of the compounds with the commercial insecticides, bactericides, plant virus resisting agents and plant activators in the prevention and treatment of the diseases, insect pests and viral diseases in agriculture, forestry and horticulture and a preparation method thereof.

Description

One class contains anthranilic diamides derivative of N-cyano group sulfone (sulphur) imines and its production and use
Technical field
Technical scheme of the present invention relates to pyrazole compound, is specially the anthranilic diamides derivative containing N-cyano group sulfone (sulphur) imines.
Background technology
Since doctor Tsuda in 1989 since the vertical university of Osaka, Japan has reported that a series of pyrazine diamide compounds have certain insecticidal activity, diamide compound just becomes the focus of Ge great agricultural chemicals company and R&D institution's research in the world.Until 1998, Japanese agricultural chemicals company has just found first bisamide insecticides---Flubendiamide (EP1006107).This insecticides is except according to there being excellent activity, without cross resistance, and to beyond the advantages such as mammalian safe, also has unique mechanism of action with existing sterilant.Its particular mechanism of this bisamide insecticides may be suppress calcium ion release and become ryanodine receptor activator.The mechanism of action of this uniqueness has attracted the research of global agricultural chemicals company to ryanodine receptor activator insecticides very soon.2000, du pont company just found second ryanodine receptor agonist insecticides---chlorantraniliprole (WO03015519), and the successfully listing in 2007.Subsequently, further composition optimizes is done to chlorantraniliprole by du pont company, has found the more s-generation ryanodine receptor insecticides of wide spectrum---cyanogen insect amide (WO2004067528) of desinsection.
Although bisamide insecticides shows outstanding superiority aspect active, some areas are due to frequent excessively dispenser, and insect has showed resistance in various degree, and up to the present the commercial kind number of this insecticides is very limited.In order to overcome current this situation, find more ryanodine receptor sterilant and the relevant agricultural chemicals of high biological activity, the adjacent formamide benzene Carbox amide that fluorine-containing methoxyl group pyrazoles has been studied by Zhejiang chemical research institute has more effectively, low toxicity, low cost, the advantage (CN101967139A) such as environmentally safe.Domestic Duo Jia research unit is all carrying out relevant initiative research work, does not also have activity to exceed the report of target molecule parent activity at present.Recently, Syngenta Co.,Ltd introduces N-cyano group sulfone (sulphur) imine structure in the structure of benzamide, find that the synthetic target compound of design has good insecticidal activity (Christian Gnamm, Novel diamide insecticides:sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives, Bioorganic & Medicinal Chemistry Letters, 2012,22:3800-3806).
Ryanodine receptor insecticides is due to the feature of molecule self, its migration in plant materials is subject to certain restrictions, in order further to study the ryania compounds of high-efficiency low-toxicity, the present invention utilizes the principle of pesticide molecule design that other pesticide activity fragments are introduced in bisamide molecule, the anthranilic diamides derivative of a class containing N-cyano group sulfone (sulphur) imines synthesized in design, and carry out the bioactive screening of system, to improving the water-soluble of target molecule, improve its upper and lower and lateral migration in plant materials, for the initiative research of novel pesticide provides eco-friendly ultra-high efficiency novel candidate compound.
Summary of the invention
Technical problem to be solved by this invention is: the synthetic method that the new anthranilic diamides derivative containing N-cyano group sulfone (sulphur) imines is provided, biological activity and measuring method thereof that this compounds regulation and control agricultural, gardening and health and forestry plant insect and the phytopathy original are provided provide the middle application of these compounds at agriculture field, gardening field, field of forestry and health field simultaneously.
The present invention solves this technical problem adopted technical scheme: the chemical structure of general formula with the anthranilic diamides derivative of N-cyano group sulfone (sulphur) imines of agriculture field, gardening field, forestry and health field insecticidal activity, fungicidal activity, anti-phytoviral activity, inducing plant generation anti-disease activity, insect growth regulator activity is shown in formula I
Wherein, X is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; Y is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; R 1be selected from: substituted alkyl, replacement unsaturated alkyl, methylthio group substituted alkyl, methylthio group replace unsaturated alkyl, cyano group, substituted sulphonyl, substituted-amino formyl radical; X is preferred: chlorine, bromine; Y is preferred: chlorine, bromine; R 1preferred: 2-methylmercaptoethyl, 2-((N-cyano group) methyl sulfilimine base) ethyl, 2-((N-cyano group) methyl sulfone imido grpup) ethyl, the 2-methylthio group tertiary butyl, 2-((N-cyano group) the methyl sulfilimine base) tertiary butyl, 2-((N-cyano group) methyl sulfone imido grpup) tertiary butyl; Specifically can be divided into following 3 kinds of structure types:
Wherein, X is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; Y is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; R 2be selected from: H, substituted alkyl, replacement unsaturated alkyl, substituted aryl; X is preferred: Cl, Br; Y is preferred: C1, Br; R 2preferred: H, CH 3.
It is synthetic that anthranilic diamides derivative I, IA, IB, IC containing N-cyano group sulfone (sulphur) imines of the present invention presses the method shown in Scheme-1:
Wherein, X is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; Y is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; R 2be selected from: H, substituted alkyl, replacement unsaturated alkyl, substituted aryl; X is preferred: Cl, Br; Y is preferred: Cl, Br; R 2preferred: H, CH 3.
Scheme-1 is containing anthranilic diamides derivative I, IA, IB, the IC synthetic route of N-cyano group sulfone (sulphur) imines
Specifically be divided into following steps:
A. replace the preparation of benzoxazine IV:
In 50 milliliters of round-bottomed flasks, add 15 milliliters of acetonitriles, 1.0 mmole 3-replacement-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II, 5 mmole Methanesulfonyl chlorides, be abbreviated as the i.e. 5 mmole pyridines of MsCl, 0.4 gram, be abbreviated as Py, be cooled to-5 degrees Celsius, stirring after 30 minutes adds 1.0 mmoles to replace anthranilic acid, slowly rise to after room temperature and stir and spend the night, having yellow solid to replace benzoxazine IV separates out, filter, washing, vacuum-drying, is directly used in next step reaction, described 3-replacement-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II is selected from the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid, the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid, described replacement benzoxazine IV is selected from 2-(the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl) the chloro-4-oxo-4H-of-8-methyl-6-benzo-[d] [1, 3]-oxazines, 2-(the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl) the bromo-4-oxo-4H-of-8-methyl-6-benzo-[d] [1, 3]-oxazines, 2-(the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl) the chloro-4-oxo-4H-of-8-methyl-6-benzo-[d] [1, 3]-oxazines, 2-(the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl) the bromo-4-oxo-4H-of-8-methyl-6-benzo-[d] [1, 3]-oxazines.
B.1-the preparation of (3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-(methylthio group alkyl) amido formacyl) aniline IA:
In 50 milliliters of round-bottomed flasks, add 0.5 mmole to replace benzoxazine IV, 20 milliliters of tetrahydrofuran (THF)s, be abbreviated as the replacement methylmercaptan ethyl ammonia of THF, 5.0 mmoles, reaction mixture stirring at room temperature 7 hours; Concentrating under reduced pressure is except desolventizing, gained resistates obtains yellow or white solid 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-(methylthio group alkyl) amido formacyl) aniline IA through 200～300 order purification by silica gel column chromatography, eluent is the sherwood oil of 60～90 degrees Celsius: ethyl acetate, and volume ratio is 3: 1; With gained sterling calculated yield, yield 40-70%; The amount of synthetic compound expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles.Described 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-(methylthio group alkyl) amido formacyl) aniline IA is selected from the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline.
C.1-the preparation of (3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfilimine base) alkyl) amido formacyl) aniline IB:
In 50 milliliters of round-bottomed flasks, add 0.5 mmole 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-(methylthio group alkyl) amido formacyl) aniline IA, 15 milliliters of dry methylene dichloride, ice-water bath is cooled to 0 degree Celsius.Then add respectively 1.0 mmole cyanamides and 0.5 mmole acetic acid iodobenzene; at this temperature, stir stirred overnight at room temperature after 3 hours; the 2nd day by direct reaction solution removal of solvent under reduced pressure; resistates obtains faint yellow or white solid 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfilimine base) alkyl) amido formacyl) aniline IB through 200～300 order purification by silica gel column chromatography; eluent is ethyl acetate; with gained sterling calculated yield, yield 40-60%.The amount of synthetic compound expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles.Described 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfilimine base) alkyl) amido formacyl) aniline IB is selected from the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline.
D.1-the preparation of (3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfoximide base) alkyl) amido formacyl) aniline IC:
In 50 milliliters of three mouthfuls of round-bottomed flasks, add 1.0 mmole metachloroperbenzoic acids, write a Chinese character in simplified form m-CPBA, 8 milliliters of ethanol, ice-water bath is cooled to 0 degree Celsius and stirs 10 minutes, then by 1.5 mmole Anhydrous potassium carbonates 7 ml water solution is disposable adds, have a large amount of white solids to separate out.0 degree Celsius of stirring dropwise added 8 milliliters of ethanolic solns of 0.5 mmole 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfilimine base) alkyl) amido formacyl) aniline IB after 20 minutes, stirred and after 1 hour, reaction solution was quenched in water; Then with 50 milliliters of ethyl acetate extractions three times, saturated common salt water washing 2 times for organic layer, anhydrous magnesium sulfate drying, removal of solvent under reduced pressure, resistates obtains faint yellow or white solid 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfoximide base) alkyl) amido formacyl) aniline IC through 200～300 order purification by silica gel column chromatography, eluent is the sherwood oil of 60～90 degrees Celsius: ethyl acetate, according to the difference of product, volume ratio is between 1: 1～1: 3; With gained sterling calculated yield, yield 50-70%.The amount of synthetic compound expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles.Described 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfoximide base) alkyl) amido formacyl) aniline IC is selected from the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline.
In the time of X=halogen, it is synthetic that substituted pyrazolecarboxylic-5-formic acid II presses the method shown in Scheme-2:
E.2-the preparation of diazanyl substituted pyridines VI:
By 50 mmoles 2, hydrazine hydrate, 50 milliliters of ethanol of 3-chloropyridine V, 100 mmoles join in 100 milliliters of three mouthfuls of round-bottomed flasks, 80 degrees Celsius of lower reflux 20 hours, remove solvent under reduced pressure, gained solid obtains intermediate 2-diazanyl substituted pyridines VI with ethyl alcohol recrystallization, with gained sterling calculated yield, yield 91%.The amount of synthetic 2-diazanyl substituted pyridines VI expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles.
F.2-the preparation of (3-chloropyridine-2-yl)-5-oxopyrazoline alkane-3-ethyl formate VII:
In 100 milliliters of reaction flasks, add 50 milliliters of ethanol, slowly add the sodium Metal 99.5 of 55 mmoles, back flow reaction is made alcohol sodium solution. under reflux state, add the ethyl maleate of 50 mmole 2-diazanyl substituted pyridines VI, 60 mmoles, continue to reflux 30 minutes, then cooling, filters, and gained solid obtains yellow solid 2-(3-chloropyridine-2-yl)-5-oxopyrazoline-3-ethyl formate VII by cold washing with alcohol, with gained sterling calculated yield, yield 70%.The amount of synthetic 2-(3-chloropyridine-2-yl)-5-oxopyrazoline-3-ethyl formate VII expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles.
G.3-halo-1-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate VIII's is synthetic
To adding 5.4 grams of i.e. 20 mmole 2-(3-chloropyridine-2-yl)-5-oxopyrazoline-3-ethyl formate VII, 50 milliliters of acetonitriles, 30 mmole three oxyhalogen phosphorus, stirring and refluxing 3 hours in 100 milliliters of single necked round bottom flask; Concentrate and remove most of solvent, resistates is dissolved in methylene dichloride, use successively saturated sodium bicarbonate aqueous solution and saturated common salt water washing, anhydrous sodium sulfate drying is concentrated, thick product obtains yellow oil VIII through 200～300 order purification by silica gel column chromatography, eluent is the sherwood oil of 60～90 degrees Celsius: ethyl acetate, and volume ratio is 3: 1; With gained sterling calculated yield, yield 80-90%; Synthetic 3-halo-1-(3-chloropyridine-2-yl)-4, the amount of 5-dihydro-1 h-pyrazole-5-ethyl formate VIII expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles; Described three oxyhalogen phosphorus are selected from phosphorus oxychloride, tribromo oxygen phosphorus; Described 3-halo-1-(3-chloropyridine-2-yl)-4, the VIII of 5-dihydro-1 h-pyrazole-5-ethyl formate is selected from the chloro-1-of 3-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate, the bromo-1-of 3-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate.
H.3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate IX's is synthetic
In 100 milliliters of reaction flasks, add the 3-halo-1-(3-chloropyridine-2-yl)-4 of 30 mmoles of above-mentioned preparation, 5-dihydro-1 h-pyrazole-5-ethyl formate VIII, 50 milliliters of acetonitriles, slowly add 3 milliliters of vitriol oils, then add the Potassium Persulphate of 40 mmoles, reflux 3 hours, then cooling, pours into and in frozen water, filters to obtain yellow solid 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate IX, with gained sterling calculated yield, yield 65-75%.The amount of synthetic compound expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles; Described 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate IX is selected from the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate, the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate.
I.3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II's is synthetic
To adding successively 1.0 grams of i.e. i.e. 5.0 mmole sodium hydroxide of 3.0 mmole 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate, 10 ml methanol, 0.2 gram, stirring at room temperature 8 hours in 50 milliliters of single necked round bottom flask.After TLC monitoring reaction finishes, concentratedly remove most of solvent, add 20 milliliters of frozen water, the aqueous solution wash once by ethyl acetate, is acidified to pH=4 with 2 mol/L dilute hydrochloric acid, and adularescent solid generates, filtration, and filter cake is washed, and vacuum-drying, obtains faint yellow solid II.The amount of synthetic 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles; Described 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II is selected from the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid, the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid.
Replacing the anthranilic acid III method shown in Scheme-3 of pressing synthesizes:
Concrete operations are:
J. replace the preparation of anthranilic acid III:
In 100 milliliters of round-bottomed flasks, add 20 mmole 3-methyl-2-amino phenylformic acid X, 50 milliliters of DMF, 30 mmole N-chlorosuccinimides (or N-bromosuccinimide), after return stirring 3 hours, reaction solution is poured in frozen water, dilute hydrochloric acid is acidified to pH=6, filter, gained precipitation obtains gray solid by a small amount of washing with alcohol and replaces anthranilic acid III, and by gained sterling calculated yield, yield is greater than 83%; The synthetic amount that replaces anthranilic acid III expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles.Described replacement anthranilic acid III is selected from 2-amido-3-methyl-5-chloro phenylformic acid, 2-amido-3-methyl-5-bromo-benzoic acid.
K. anthranilic diamides derivative I, IA, IB, the mensuration of IC to aphid cytotoxicity containing N-cyano group sulfone (sulphur) imines of the present invention:
Anthranilic diamides derivative I, IA, IB, IC containing N-cyano group sulfone (sulphur) imines of the present invention is as follows to the insecticidal activity screening method of aphid larva: adopt pickling process, black bean aphid (Aphis laburni Kaltenbach) (ALK), the normal population of indoor feeding; Take 2.5 milligrams of test compounds in beaker, drip 1 DMF (DMF), add 5 milliliters of acetone vibrations and dissolve samples, then add and have the water of tween 80 to be mixed with the solution to be measured of 200 ug/ml; By cutting from basin for examination bean plant with at least 60 black bean aphids, in each liquid to be measured, flooded for 5 seconds, take out and get rid of gently unnecessary liquid, be inserted in by moisturizing on water saturated sponge, after liquid is dry with on lens cover, the opening of lens upper end, is raised to place after 24 hours and is checked aphid death state in case aphid escapes with gauze sealing, and standard is: with try worm can creep maybe can stand or six Tiao Tuineng strenuous exercises be worm alive; Taking clear water as contrast, the positive contrast of Provado, calculation correction mortality ratio;
L. anthranilic diamides derivative I, IA, IB, the mensuration of IC to mythimna separata insecticidal activity containing N-cyano group sulfone (sulphur) imines of the present invention:
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC adopt leaf dipping method to the screening of mythimna separata insecticidal activity: on analytical balance, take 2 milligrams of medicine samples in 10 ml penicillin vials, add 10 milliliters of acetone, become the mother liquor of 200 ug/ml, covering plug vibration dissolves, then liquid is become to the working fluid of 5 ug/ml by acetone diluted, with straight peen ophthalmology tweezers soaking maize blade, 2～3 seconds time, get rid of remaining liquid.Each 1, totally 8, each sample; Be successively placed in treatment paper by sample flag sequence, after liquid is dry, put into the culture dish of the markd 10cm of tool, at the beginning of accessing 10 3 ages with elbow ophthalmology tweezers, incubate armyworm larvae, test is processed and is placed in constant temperature standard insectary and cultivates check result after 24 hours or 48 hours, touch larva body with little writing brush or tweezers, completely motionless as death standard taking larva; With the positive contrast of cyanogen insect amide, with the leaf of Semen Maydis of acetone soln dipping be blank.Carry out the determination of activity of compound 1.0 ug/ml and 0.1 ug/ml concentration simultaneously.
M. anthranilic diamides derivative I, IA, IB, the mensuration of IC to small cabbage moth insecticidal activity containing N-cyano group sulfone (sulphur) imines of the present invention:
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC adopt blade medicine embrane method to the screening of small cabbage moth insecticidal activity: sample to be tested is mixed with the solution of 200 ug/ml, get former medicine sample and first use a small amount of acetone solution, then with 0.5 ‰ Triton-100 aqueous solution dilutions, the 0.5 ‰ Triton-100 aqueous solution are contrast, each concentration repeats for 3 times, 10 examination worms of each re-treatment; Get fresh free of contamination cabbage leaves, in liquid, soaked for 10 seconds, after indoor drying (approximately 2 hours), put into the culture dish of 9 centimetres of diameters, small cabbage moth 2 instar larvaes that access size is respectively basically identical, tighten and are placed in small cabbage moth constant temperature insectary with bungee, check result after 96 hours or 120 hours, touch polypide with little writing brush or tweezers, can not coordinated movement as death; With the positive contrast of cyanogen insect amide.Carry out the determination of activity of compound 5.0 ug/ml and 1.0 ug/ml concentration simultaneously.
N. anthranilic diamides derivative I, IA, IB, the mensuration of IC to pathogenic fungi fungicidal activity containing N-cyano group sulfone (sulphur) imines of the present invention:
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC sterilization or bacteriostatic activity adopt thalli growth rate assay method, detailed process is: get 5 milligrams of sample dissolution in appropriate dimethyl formamide, then with the medicament that contains a certain amount of polysorbas20 emulsifier aqueous solution and be diluted to 500 ug/ml, by reagent agent each absorption in 1 milliliter of injection culture dish under aseptic condition, add respectively again 9 milliliters of substratum, after shaking up, make 50 ug/ml pastille flat boards, do blank with the flat board that adds 1 milliliter of aqua sterilisa, cut bacterium dish along mycelia outer rim with the punch tool of 4 millimeters of diameters, move on pastille flat board, being equilateral triangle puts, every processing repeats 3 times, culture dish is placed in 24 ± 1 degrees Celsius of constant incubators and is cultivated, colony diameter to be contrasted expands to 2-3 centimetre of " Invest, Then Investigate " and respectively processes bacterium dish expansion diameter, average, relatively calculate relative bacteriostasis rate with blank, comprise the kind of multiple representative majority of plant pathogenic bacteria of the actual generation in field in China's agriculture production for examination bacterial classification, its title and code name comprise AS: tomato early blight bacterium (Alternaria solani), BC: botrytis cinerea pers (Botrytis cinerea), CA: peanut Cercospora bacteria (Cercospora arachidicola), GZ: fusarium graminearum (Gibberella zeae), PI: phytophthora infestans (Phytophthora infestans (Mont.) de Bary), PP: Botryosphaeria berengeriana f. sp (Physalospora piricola), PS: Rhizoctonia solani Kuhn (Pellicularia sasakii), RC: Rhizoctonia cerealis (Rhizoctonia cerealis), SS: Sclerotinia sclerotiorum (Sclerotinia sclerotiorum).
The invention has the beneficial effects as follows: the present invention has carried out the optimization of guide structure to anthranilic diamides derivative I, IA, IB, IC containing N-cyano group sulfone (sulphur) imines, and synthetic new compound has been carried out to desinsection, antibacterial and inducing anti-disease activity, the mensuration of anti-phytoviral activity and the research that mixing is used, this compounds can be used for disease, insect pest and the virus disease control in agriculture field, field of forestry, gardening field.
The present invention by by specific preparation and biological activity determination and with the formulation that commercially available agricultural chemical is used in combination complete processing and selection be that embodiment more specifically describes synthetic and biological activity and the application thereof containing the anthranilic diamides derivative I of N-cyano group sulfone (sulphur) imines, IA, IB, IC, but described embodiment is unrestricted the present invention for specific description the present invention only, especially its biological activity and complete processing only illustrate, and unrestricted this patent, embodiment is as follows:
Embodiment 1
3-methyl-5-halo-2-benzaminic acid III's is synthetic:
In 100 milliliters of round-bottomed flasks, add 3.0 grams of i.e. 20 mmole 3-methyl-2-amino phenylformic acid X, 30 milliliters of DMF, 6.7 grams of i.e. 30 mmole NCS (or 30 mmole NBS), after return stirring 3 hours, reaction solution is poured in frozen water, dilute hydrochloric acid is acidified to pH=6, filter, gained solid obtains 2-amino-3-methyl-5-halo-phenylformic acid III, gray solid by a small amount of washing with alcohol, more than 4.6 grams, yield is greater than 83%.Y is selected from: chlorine, bromine, described be selected from-2-of 2-amino-3-methyl-5-halo-phenylformic acid III amino-3-methyl-5-chloro phenylformic acid, the bromo-phenylformic acid of 2-amino-3-methyl-5-; Wherein, 2-amino-3-methyl-5-chloro phenylformic acid 1h NMR (400MHz, DMSO-d 6): δ: 7.96 (s, 1H), 7.56 (d, 1H), 7.23 (d, 1H), 2.11 (s, 3H); 2-amino-3-methyl-5-bromo-benzoic acid 1hNMR (300MHz, DMSO-d 6): δ: 7.70 (s, 1H), 7.31 (s, 1H), 2.10 (s, 3H).
Embodiment 2
The preparation of 3-halo-1-(3-chloropyridine-2-yl)-N-(4-halo-2-methyl-6-((2-(methylthio group) alkyl) formamyl) phenyl)-1H-pyrazoles-5-methane amide
(1) 3-chloride-2-hydrazinopyridine VI's is synthetic:
By 50 mmoles 2, hydrazine hydrate, 50 milliliters of ethanol of 3-pyridine V, 100 mmoles join in 100 milliliters of three mouthfuls of round-bottomed flasks, and 80 degrees Celsius of lower reflux 20 hours, remove solvent under reduced pressure, gained solid obtains needle-like crystal 3-chloride-2-hydrazinopyridine VI6.5 gram, yield 90% with ethyl alcohol recrystallization.
(2) 5-oxo-2-(3-chloropyridine-2-yl) pyrazoline-3-ethyl formate VII's is synthetic:
In 250 milliliters of single necked round bottom flask, add 100 milliliters of absolute ethanol, add 1.77 grams of i.e. 55 mmole sodium Metal 99.5s in batches, temperature slightly rises, and stirs and forms transparent and homogeneous solution after 10 minutes; Add 7.1 grams of i.e. 50 mmole 3-chloride-2-hydrazinopyridine VI formation yellow suspension, be heated to reflux, drip 11.2 grams of i.e. 65 mmole ethyl maleates under reflux state, drip and finish, continuation refluxes 1 hour; After TLC monitoring reaction finishes, be cooled to 40 degrees Celsius, add 3.5 milliliters of glacial acetic acids; Reaction mixture is concentrated near dry, and thick product obtains 7.9g yellow solid VII, yield 59% with ethyl alcohol recrystallization; 1h NMR (300MHz, CDCl 3) δ 8.26 (dd, 1H), 7.89 (dd, 1H), 7.19 (dd, 1H), 4.80 (dd, 1H), 4.20 (q, 2H), 2.90 (dd, 1H,), 2.35 (dd, 1H), 1.24 (t, 3H, CH 3).
(3) 3-halo-1-(3-chloropyridine-2-yl)-4,5-dihydro-1II-pyrazole-5-ethyl formate VIII's is synthetic
To adding 5.4 grams of i.e. 20 mmole 5-oxo-2-(3-chloropyridine-2-yl) pyrazoline-3-ethyl formate VII, 50 milliliters of acetonitriles, 30 mmole three halo oxygen phosphorus in 100 milliliters of single necked round bottom flask, be abbreviated as P (0) X 3, X is Cl, Br, stirring and refluxing 3 hours; Concentrate and remove most of solvent, resistates is dissolved in methylene dichloride, use successively saturated sodium bicarbonate aqueous solution and saturated common salt water washing, anhydrous sodium sulfate drying, concentrated, thick product obtains yellow oil 3-halo-1-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate VIII through 200～300 order purification by silica gel column chromatography, eluent is the sherwood oil of 60～90 degrees Celsius: ethyl acetate, and volume ratio is 3: 1; With gained sterling calculated yield, yield 80-90%.Three described halo oxygen phosphorus are selected from phosphorus oxychloride, tribromo oxygen phosphorus; Described 3-halo-1-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate VIII is selected from the chloro-1-of 3-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate, the bromo-1-of 3-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate; The wherein chloro-1-of 3-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate 1hNMR (400MHz, CDCl 3) δ: 8.08 (dd, 1H), 7.65 (dd, 1H), 6.86 (dd, 1H), 5.30 (dd, 1H), 4.18 (q, 2H), 3.42-3.15 (m, 2H), 1.20 (, 3H); The bromo-1-of 3-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate 1hNMR (300MHz, CDCl 3) δ: 8.07 (dd, 1H), 7.66 (dd, 1H), 6.85 (dd, 1H), 5.30 (dd, 1H), 4.18 (q, 2H), 3.43-3.14 (m, 2H), 1.20 (t, 3H).
(4) 3-halo-1-(3-chloropyridine-2-yl)-IH-pyrazole-5-ethyl formate IX's is synthetic
In 100 milliliters of single necked round bottom flask, add 10 mmole 3-halo-1-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate VIII, 30 milliliters of acetonitriles, 1.1 milliliter of 98% vitriol oil, stir 5 minutes, add 3.3 grams of i.e. 15 mmole Potassium Persulfates, stirring and refluxing 3 hours; Reaction mixture is poured in 300 milliliters of frozen water after being cooled to room temperature, filter, gained solid obtains yellow crystals 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate IX with ethyl alcohol recrystallization, with gained sterling calculated yield, yield 64-70%; Described 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate IX is selected from the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate, the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate; The wherein chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate 1h NMR (400MHz CDCl 3) δ: 8.51 (dd, 1H), 7.91 (dd, 1H), 7.45 (dd, 1H), 6.95 (s, 1H), 4.23 (q, 2H), 1.22 (t, 3H); The bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate 1h NMR (300MHz CDCl 3) δ: 8.50 (dd, 1H), 7.89 (dd, 1H), 7.44 (dd, 1H), 6.95 (s, 1H), 4.23 (q, 2H), 1.20 (t, 3H).
(5) 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II's is synthetic
In 50 milliliters of single necked round bottom flask, add successively 3.0 mmole 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate IX, 10 ml methanol, 0.2 gram is 5.0 mmole sodium hydroxide, stirring at room temperature 8 hours, after TLC monitoring reaction finishes, concentrate and remove most of solvent, add 20 milliliters of frozen water, the aqueous solution washs once by ethyl acetate, 2 mol/L dilute hydrochloric acid are acidified to pH=4, adularescent solid generates, filter, filter cake washing, vacuum-drying, obtain faint yellow solid 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II0.63g, yield 70%, described 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II is selected from 3-chloro-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid, 3-bromo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid, wherein 3-chloro-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid 1h NMR (400MHzDMSO-d6) δ: 14.32 (s, br, 1H), 8.56 (dd, 1H), 8.26 (dd, 1H), 7.69 (dd, 1H), 7.20 (s, 1H), 3-bromo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid 1h NMR (400MHz DMSO-d6) δ: 13.94 (s, br, 1H), 8.54 (dd, 1H), 8.24 (dd, 1H), 7.66 (dd, 1H), 7.24 (s, 1H).
(6) 6-halo-2-(3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl)-8-methyl-4H-3,1-benzoxazine-4-ketone IV's is synthetic
In 50 milliliters of round-bottomed flasks, add 10 milliliters of acetonitriles, 1.0 mmole 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II, 0.57 gram is 5 mmole Methanesulfonyl chlorides, 0.4 gram is 5 mmole pyridines, be cooled to-5 degrees Celsius, stir and after 30 minutes, add 01.0 mmole 2-amino-3-methyl-5-halogenated benzoic acid III, slowly rise to after room temperature and stir and spend the night, there is yellow solid 6-halo-2-(3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl)-8-methyl-4H-3, 1-benzoxazine-4-ketone IV separates out, filter, washing, after vacuum-drying, be directly used in next step reaction, described 3-methyl-5-halo-2-benzaminic acid II is selected from 3-methyl-5-chloro-2-benzaminic acid, the bromo-2-benzaminic acid of 3-methyl-5-, described be selected from-2-of 2-amino-3-methyl-5-halo-phenylformic acid III amino-3-methyl-5-chloro phenylformic acid, the bromo-phenylformic acid of 2-amino-3-methyl-5-, described 6-halo-2-(3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl)-8-methyl-4H-3, 1-benzoxazine-4-ketone IV is selected from the chloro-2-of 6-(the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl)-8-methyl-4H-3, 1-benzoxazine-4-ketone, the chloro-2-of 6-(the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl)-8-methyl-4H-3, 1-benzoxazine-4-ketone, the bromo-2-of 6-(the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl)-8-methyl-4H-3, 1-benzoxazine-4-ketone, the bromo-2-of 6-(the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl)-8-methyl-4H-3, 1-benzoxazine-4-ketone.
(7) preparation of 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-(methylthio group alkyl) amido formacyl) aniline IA
In 50 milliliters of three mouthfuls of round-bottomed flasks, add successively 0.5 mmole 6-halo-2-(3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl)-8-methyl-4H-3,1-benzoxazine-4-ketone IV, 10 milliliters of acetonitriles, drip 0.9 gram of i.e. 10.0 mmole methylthio group ethamine or 2-methylthio group TERTIARY BUTYL AMINE, drip complete stirring at room temperature 4 hours; After TLC monitoring reaction finishes, rotary evaporation is except desolventizing, add saturated sodium bicarbonate aqueous solution to stir 10 minutes, 20 milliliters of ethyl acetate extract three times, merge organic phase and use saturated common salt water washing, anhydrous sodium sulfate drying, concentrate to obtain resistates, obtain white solid IA through 200～300 order purification by silica gel column chromatography, eluent is the sherwood oil of 60～90 degrees Celsius: ethyl acetate, and volume ratio is 2: 1; By gained sterling calculated yield; The concrete physical parameter of IA is in table 1.Described 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-(methylthio group alkyl) amido formacyl) aniline IA is selected from the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline.
Embodiment 3
1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfilimine base) alkyl) amido formacyl) aniline IB's is synthetic
In 50 milliliters of three mouthfuls of round-bottomed flasks, add 0.53 gram of i.e. 1.0 mmole 3-halo-1-(3-chloropyridine-2-yl)-N-(4-halo-2-methyl-6-(2-(methylthio group alkyl) formamyl) phenyl)-1H-pyrazoles-5-methane amide IA; add 30 milliliters of dry tetrahydrofuran (THF)s to stir, ice-water bath is cooled to 0 degree Celsius.Then add respectively 0.16 gram of i.e. i.e. 1.0 mmole acetic acid iodobenzene of 4 mmole cyanamides and 0.33 gram, at this temperature, stir stirred overnight at room temperature after 3 hours, the 2nd day by direct reaction solution removal of solvent under reduced pressure, resistates obtains white solid IB through 200～300 order purification by silica gel column chromatography, eluent is ethyl acetate, and the physical and chemical parameter of IB is in table 1.Described 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfilimine base) alkyl) amido formacyl) aniline IB is selected from the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline.
Embodiment 4
1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfoximide base) alkyl) amido formacyl) aniline IC's is synthetic
In 50 milliliters of three mouthfuls of round-bottomed flasks, add 0.17 gram of i.e. 1.0 mmole metachloroperbenzoic acids, 8 milliliters of DMF, ice-water bath is cooled to 0 degree Celsius and stirs 10 minutes, then by 0.27 gram 2.9 mmole Anhydrous potassium carbonates 7 ml water solution is disposable adds, have a large amount of white solids to separate out; 0 degree Celsius stir after 20 minutes by 0.28 gram 8 milliliters of DMF solution of 0.5 mmole 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfilimine base) alkyl) amido formacyl) aniline IB dropwise add, stir and after 1 hour, reaction solution quenched in water; Then with 50 milliliters of ethyl acetate extractions three times, saturated common salt water washing 2 times for organic layer, anhydrous magnesium sulfate drying, removal of solvent under reduced pressure, resistates obtains white solid IC through 200～300 order purification by silica gel column chromatography, and eluent is ethyl acetate, and the physical and chemical parameter of IC and structural parameter are in table 1.Described 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfoximide base) alkyl) amido formacyl) aniline IC is selected from the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline.
Embodiment 5
The insecticidal activity of anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC the results are shown in Table 2 to the insecticidal activity assay of mythimna separata, data show, in the time of 5 ug/ml, Hxw002-45 of the present invention, Hxw003-5, Hxw003-8, Hxw003-9, Hxw003-18, Hxw003-21, Hxw003-24, Mt007-36-1, Mt007-41-1, Hxw003-20, Hxw003-23, Hxw003-26, Hxw003-22, Hxw003-27, Lfy001-8-1, Mt007-46-1, Mt007-47-1, Zgn001-14-1, Mt007-44-1, Mt007-45-1 has all shown excellent mythimna separate, in administration after 48 hours, mortality ratio all reaches 100%, suitable with the activity of positive control medicament cyanogen insect amide.Hxw003-10, Hxw003-15, Mt007-37-1, Hxw003-25 are respectively 40%, 70%, 70%, 60% to the insecticidal activity of mythimna separata.Be significantly higher than these 20 kinds of compounds of other medicaments for activity, with 1.0 ug/ml and 0.1 ug/ml, mythimna separata is carried out to multiple sieve respectively, result shows, under 1.0 ug/ml concentration, Mt007-46-1 of the present invention has shown excellent mythimna separate, in administration after 48 hours, mortality ratio reaches 100%, and Hxw003-21, Hxw003-20, Lfy001-8-1, Zgn001-14-1 have also shown good mythimna separate, in administration, after 48 hours, mortality ratio is all more than 40%; Hxw002-45, Hxw003-9, Hxw003-27 have also reached 20% to the insecticidal activity of mythimna separata.And its insecticidal activity of compound Mt007-50-1 that CN replaces only has 80%.
Anthranilic diamides derivative I, IA, IB, IC containing N-cyano group sulfone (sulphur) imines of the present invention the results are shown in Table 3 to the insecticidal activity assay of small cabbage moth, when 200 ug/ml, all sulfide derivatives, sulfinilimine derivatives and sulfoximide derivative have all reached 100% to the activity of small cabbage moth, suitable with the insecticidal activity of cyanogen insect amide, the introducing of thioether, sulfilimine, sulfoximide does not affect insecticidal activity; And the activity of the derivative Mt007-50-1 that CN replaces only has 75%, therefore, the introducing of halogen is conducive to active raising and maintenance.When 10 ug/ml, the activity of Hxw002-45, Hxw003-9, Hxw003-10, Hxw002-15, Hxw003-21, Mt007-36-1, Mt007-37-1, Hxw003-22, Hxw003-25, Lfy001-8-1, Zgn001-14-1 etc. reaches 100%, higher than 90% of cyanogen insect amide; Therefore, be equally the activity that the activity of derivative that halogen replaces is better than the derivative that CN replaces; The activity of other compounds of the present invention is also more than 50%.
Aphid determination of activity the results are shown in Table 3, in the time of 200 ug/ml, insecticidal activity result to aphid shows, derivative, the derivative of sulfilimine and the derivative of sulfoximide that thioether replaces all have good killing aphis activity, and cyanogen insect amide does not almost have killing aphis activity; The compound that halogen of the present invention replaces is significantly higher than the methyl substituted compound Mt007-50-1 of fork to the activity of aphid.
Systemic activity test result shows, the derivative that thioether replaces has certain systemic activity, the derivative of sulfilimine has good systemic activity, the derivative of sulfoximide has extraordinary systemic activity, the systemic activity of all compounds is all higher than the systemic activity of cyanogen insect amide, and cyanogen insect amide does not almost have systemic activity.
Embodiment 6
Antibacterial or the fungicidal activity of anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC:
Title and the code name of the frequently seen plants pathogenic fungi of the present invention's test comprise AS: tomato early blight bacterium (Alternaria solani); BC: botrytis cinerea pers (Botrytis cinerea); CA: peanut Cercospora bacteria (Cercospora arachidicola); GZ: fusarium graminearum (Gibberella zeae); PI: phytophthora infestans (Phytophthora infestans (Mont.) de Bary); PP: Botryosphaeria berengeriana f. sp (Physalospora piricola); PS: Rhizoctonia solani Kuhn (Pellicularia sasakii); RC: Rhizoctonia cerealis (Rhizoctonia cerealis); SS: Sclerotinia sclerotiorum (Sclerotinia sclerotiorum), these bacterial classifications have good representativeness, can represent the kind of most of pathogenic bacteria that in agriculture production, field occurs.Thalli growth rate method measurement result is in table 3, and table 3 shows, in the time of 50 ug/ml, all compounds that the present invention synthesizes all have fungicidal activity in various degree, Mt007-45-1 to the fungicidal activity of AS bacterium higher than 40%; Mt007-45-1 to the fungicidal activity of GZ bacterium higher than 40%; Zgn001-14-1, Mt007-45-1, Hxw003-9, Hxw003-10, Hxw003-15, Lfy001-8-1, Mt007-46-1, Hxw002-45, Hxw003-8, Mt007-36-1, Mt007-37-1, Hxw003-22, Hxw003-25, Hxw003-18, Hxw003-24 to the fungicidal activity of PP higher than 40%; Zgn001-14-1, Mt007-44-1, Lfy001-8-1, Mt007-46-1, Hxw003-5, Mt007-36-1, Mt007-37-1, Hxw003-18, Hxw003-20, Hxw003-23 to the fungicidal activity of BC higher than 40%; Zgn001-14-1, Mt007-44-1, Hxw003-15, Lfy001-8-1, Mt007-46-1, Hxw002-45, Hxw003-5, Hxw003-5, Mt007-36-1, Mt007-41-1, Hxw002-27, Hxw003-18, Hxw003-21, Hxw003-24, Hxw003-20, Hxw003-23, Hxw003-26 to the fungicidal activity of SS higher than 40%, wherein Hxw003-24 to the inhibition activity of SS bacterium higher than 80%; Zgn001-14-1, Mt007-44-1, Hxw003-9, Lfy001-8-1, Mt007-46-1, Mt007-47-1, Mt007-36-1, Mt007-41-1 to the fungicidal activity of RC higher than 40%; Zgn001-14-1, Mt007-44-1, Mt007-45-1, Lfy001-8-1, Mt007-46-1, Mt007-47-1, Mt007-36-1, Mt007-37-1, Mt007-41-1 to the fungicidal activity of PS bacterium higher than 40%.Therefore this compounds has shown good fungicidal activity.
Embodiment 7
Application in anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention and insecticide composition control agricultural and forestry and gardening plant insect pest
All anthranilic diamides derivative Is containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and existing sterilant: Chlorpyrifos 94, the sub-Nong in ground, acetamiprid, Affirm (Merck Co.), milbemectin, Avrmectin, pleocidin, fenvalerate, efficient fenvalerate, Cypermethrin, effective cypermethrin, lambda-cyhalothrin, Deltamethrin, Fenvalerate, Beta-cyfloxylate, cyfloxylate, Lambda-lambda-cyhalothrin, Permanone, permethrin, esbiothrin, cyhalothrin, bifenthrin, permethrin, ether chrysanthemum ester, flumethrin, fluvalinate, Provado, acetamiprid, Ti304, imidaclothiz, thiacloprid, Diacloden, clothianidin, MTI-446, clothianadin, Da Tenan, diflubenzuron, young urea goes out, Teflubenzuron, deinsectization is grand, HEXAFLUMURON, flufenoxuron, pyridine worm is grand, lufenuron, poisonous insect urea, penfluron, Noviflumuron is noviflumuron, and it is for No. CAS 121451-02-3, flucycloxuron, Novaluron is Rimon, fluorine pyridine urea, i.e. { 1-[(3.5-bis-chloro-4) 4-nitrophenoxy phenyl 3-3-(2-chlorobenzene)-urea } of Bay sir6874, Bay SIR-8514 i.e. [1-(4-Trifluoromethoxyphen-l)-3-(2-chlorobenzene)-urea], piperazine worm urea, Bistrifluron is bistrifluron, furan tebufenozide, worm hydrazides, chlorine worm hydrazides, methoxyfenozide, ring worm hydrazides, Rogor, omethoate, SD-1750, acephate, triazophos, Resitox, pyridaphenthione, isazofos, Ro 7-5050, SevinCarbaryl, Aphox, meta-tolyl-N-methylcarbamate (MTMC), isoprocarb, cartap, fenobucarb, leaf disperses, carbaryl, benfuracarb, carbosulfan, cartap, bromopropylate, hexythiazox, fenpyroximate, pyridaben, clofentezine, propargite, diafenthiuron, benfuracarb, pymetrozine, spiral shell mite ester, spiral shell worm ester, spiral shell worm ethyl ester, butene-fipronil, azocyclotin, Buprofezin, ethoprophos, ethiprole, desinsection list, disosultap, chlorantraniliprole, Flubendiamide, fluorine cyanogen insect amide, cyanogen insect amide, Tolfenpyrad, tebufenpyrad, bromothalonil, pyrazinones, second mite azoles, tebufenpyrad, the young ketone of rattling away, Nylar, any one in emaricin etc. or two kinds are used in combination for preventing and treating agricultural and forestry and gardening plant insect pest, anthranilic diamides derivative I, IA, IB, the quality percentage composition of IC in composition containing N-cyano group sulfone (sulphur) imines of the present invention is 1%-90%, and the ratio of anthranilic diamides derivative I, IA, IB, IC and above-mentioned sterilant containing N-cyano group sulfone (sulphur) imines of the present invention is mass percent 1%: 99% to 99%: 1%, can directly be watered rear spraying, comprise the upper acceptable solvent of agricultural and emulsifying agent and solubility promoter and synergistic agent etc. in the preparation of composition, the formulation of composition processing is selected from sustained release dosage, pulvis, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment emulsion, aqueous emulsion, granule, microemulsion, finish, with the seed of coated pesticidal, suspended emulsion agent, soluble thick agent, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, capsule suspension, dispersible dense dose, missible oil, electrostatic spray agent, water-in-oil emulsion, seed treatment agent, oil-in-water emulsion, smoke candle, granula subtilis, smoke candle, smoke cartridge, smog rod, smog sheet, smoke substance, smog ball, granular poison bait, foaming agent, ointment, thermal fog, solid-liquid mixes dress agent, liquid/liquid mixes dress agent, cold mist agent, Gu Gu/mix filling agent, medicine paint, seed treatment liquor, microgranules, oil suspending agent, finish, oil-dispersing property pulvis, paste, sheet poison bait, dense jelly, sprinkle and water agent, stylus, seed coat agent, poison bait, basting agent, fritter poison bait, suspension agent, suspension emulsion, water-soluble granule, soluble thick agent, film forming finish, tablet, follow the trail of pulvis, ultra low volume liquids, any one in steam releasing agent, the insect pest that can prevent and treat mainly contains red spider, Asiatic migrotory locust, clouding car locust, Chinese rice grasshopper, Patanga japonica (l.Bol.), single thorn mole cricket, east mole cricket, rice thrips, onion thrips, greenhouse thrips, haplothrips aculeatus, Mai Jian pipe thrips, Trialeurodes vaporariorum Westwood, Bemisia tabaci, rice green leafhopper, green leaf hopper, chlorita biguttula, spot clothing plant hopper, brown paddy plant hopper, white backed planthopper, small brown rice planthopper, the flat angle of sugarcane plant hopper, cotten aphid, green bugs, grain aphid, black peach aphid, kaoliang aphid, radish aphid, icerya purchasi, Pseudaulacaspis pentagona, unaspis shield kuwana, san jose scale, wax insect, ceroplastes rubens, Didesmococcus koreanus Borchs, pear lace bug, banana lace bug, thin corner piece stinkbug, Orius minutus, slender rice bug, paddy fly, niphe elongata, scotinophora lurida, Nezara viridula smaragdula Fabricius., green plant bug, alfalfa plant bug, black striped plant bug, chrysopa septempunctata, beautiful Chrysopa, Chinese green lacewing, rain moth, casemaking clothes moth, cnidocampa flavescens walker, brown slug moth, thosea siensis, gelechiid, pink bollworm, brachmia triannuella, small cabbage moth, small heart-eating peach worm, eating-core bean worm, small heart-eating peach worm, apple Spilonota lechriaspis, brown belt length leaf roller, Adoxophyes cyrtosema, striped rice borer, bean-pod borer, Pyrausta nubilalis (Hubern)., yellow rice borer, Oeobia undalis, Cnaphalocrocis medinali(rice leaf roller), bar snout moth's larva, the wild snout moth's larva of lap leaf, dichocrocis punctiferalis, armyworm, prodenia litura, rice green caterpillar, anomis flava, beet armyworm, pink rice borer, bollworm, ancient cooking vessel point diamond drill, black cutworm, large cutworm, yellow cutworm, steal poison moth, gypsymoth, palaearctic sweet potato, greenish brown hawk moth, straight burr rice hesperiidae, pelopidas mathias, oranges and tangerines swallowtail butterfly, Common Mormon, small white, pyrameis indica, the yellow a kind of butterfly harmful to crop plants of ramie, beans blister beetle, Venus ground beetle, wrinkle sheath ground beetle, wheat head ground beetle, pleonomus canaliculatus, Agriotes subrittatus Motschulsky, khapra beetle, attagenus piceus, the little buprestid beetle of oranges and tangerines, gold edge buprestid beetle, tenebrio molitor, dark mealworm, red flour beetle, confused flour beetle, verdigris different beetle, H. parallela, holotrichia oblita, mulberry borer, longicorn beetle, nadezhdiella cantori, pink neck longicorn, large daikon leaf beetle, daicon leaf beetle, aulacophora femoralis, Phyllotreta striolata, Callosobruchus chinensis, pea weevil, broad bean weevil, sitophilus zea-mais, rice weevil, dolerus tritici, pear fruit sawfly, yellowish leukorrhea ichneumon wasp, armyworm white star ichneumon wasp, corn earworm is hanged cocoon ichneumon wasp, bollworm tooth lip ichneumon wasp, snout moth's larva stain wart ichneumon wasp, mosquito, fly, horsefly, wheat midge, contarinia tritici, pachydiplosis oryzae, citrus fruit fly, melon trypetid, the latent fly of wheat leaf ash, Americal rice leaf miner, the black latent fly of beans stalk, frit fly, plant fly, onion fly, radish fly, full skirt chases after posts fly, Pyrausta nubilalis (Hubern). is strict posts fly, armyworm lacks must post the Agricultural pests such as fly, forestry pest, plant in control agricultural and forestry and gardening plant insect pest comprises paddy, wheat, barley, oat, corn, Chinese sorghum, sweet potato, potato, cassava, soybean, pea-pods, broad bean, pea, mung bean, red bean, cotton, silkworm and mulberry, peanut, rape, sesame, Sunflower Receptacle, beet, sugarcane, coffee, cocoa, ginseng, the bulb of fritillary, rubber, coconut, oil palm, sisal hemp, tobacco, tomato, capsicum, radish, cucumber, Chinese cabbage, celery, hot pickled mustard tube, beet, rape, green onion, garlic, watermelon, muskmelon, hami melon, pawpaw, really, tea, wild vegetable, bamboo shoots, hops, paddy rice, pepper, apple, banana, citrus, peach, papaya, orchid, potted landscape.Composition has improved the defence capability of plant in desinsection, makes plant produce the defence capability to pathogenic fungi, bacterium and virus infection.
Embodiment 8
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and miticide combination prevent and treat the application in agricultural and forestry and gardening plant mite evil
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and the upper acceptable auxiliary agent of agricultural and be selected from azocyclotin, cyhexatin, fenbutatin oxide, three phosphor tins, Zaprawa enolofos, dimethylvinphos, crotoxyphos, SD-1750, heptenopos, Phosdrin, monocrotophos, naled, Chlorpyrifos 94, Pyrimithate, imino-formyl chloride sulphur phosphorus, omethoate, dioxathion, Nialate, Malathion, methacrifos, Phosalone, Volaton, methylpyrimidine sulphur phosphorus, Resitox, sulfotep, triazophos, vamidothion, isocarbophos, acephatemet, propetamphos, dialifos, R-1504, acrinathrin, bifenthrin, cyhalothrin, essence lambda-cyhalothrin, Fenvalerate, flucythrinate, flumethrin, taufluvalinate, brofluthrinate, Bifenazate, fenothiocarb, aldicarb, butocarboxim, oxamyl, Talcord, thiofanox, F-1991, sok, carbofuran, carbosulfan, meta-tolyl-N-methylcarbamate (MTMC), promacyl, formetanate, single carbonamidine, medimeform, amitraz, chlordimeform, peruscabin, bromopropylate, cyflumetofen, acequinocyl, Nissol, flufenoxuron, macro tetrolide, piericidin, thuringiensin, tetranactin, macro tetrolide, Avrmectin, doractin, eprinomectin, ivermectin, selamectin, moxidectin, pyrethrin, nicotine, matrine, nimbin, tubatoxin, tebufenpyrad, pyridaben, fenpyroximate, clofentezine, propargite, hexythiazox, spiral shell mite ester, Fluacrypyrim, Ovotran, propargite, any one in pyridaben or two kinds of medicament combinations are prepared into miticide for preventing and treating agricultural and forestry and gardening plant mite evil, anthranilic diamides derivative I, IA, IB, the total quality percentage composition of IC in composition containing N-cyano group sulfone (sulphur) imines of the present invention is 1%-90%, and the ratio of anthranilic diamides derivative I, IA, IB, IC and above-mentioned medicament containing N-cyano group sulfone (sulphur) imines of the present invention is mass percent 1%: 99% to 99%: 1%, the formulation of composition processing is selected from sustained release dosage, pulvis, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment emulsion, aqueous emulsion, granule, microemulsion, finish, with the seed of coated pesticidal, suspended emulsion agent, soluble thick agent, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, capsule suspension, dispersible dense dose, missible oil, electrostatic spray agent, water-in-oil emulsion, seed treatment agent, oil-in-water emulsion, smoke candle, granula subtilis, smoke candle, smoke cartridge, smog rod, smog sheet, smoke substance, smog ball, granular poison bait, foaming agent, ointment, thermal fog, solid-liquid mixes dress agent, liquid/liquid mixes dress agent, cold mist agent, Gu Gu/mix filling agent, medicine paint, seed treatment liquor, microgranules, oil suspending agent, finish, oil-dispersing property pulvis, paste, sheet poison bait, dense jelly, sprinkle and water agent, stylus, seed coat agent, poison bait, basting agent, fritter poison bait, suspension agent, suspension emulsion, water-soluble granule, soluble thick agent, film forming finish, tablet, follow the trail of pulvis, ultra low volume liquids, any one in steam releasing agent, plant in composition for preventing and controlling agricultural and forestry and gardening plant mite evil is selected from paddy, wheat, barley, oat, corn, Chinese sorghum, sweet potato, potato, cassava, soybean, pea-pods, broad bean, pea, mung bean, red bean, cotton, silkworm and mulberry, peanut, rape, sesame, Sunflower Receptacle, beet, sugarcane, coffee, cocoa, ginseng, the bulb of fritillary, rubber, coconut, oil palm, sisal hemp, tobacco, tomato, capsicum, radish, cucumber, Chinese cabbage, celery, hot pickled mustard tube, beet, rape, green onion, garlic, watermelon, muskmelon, hami melon, pawpaw, really, tea, wild vegetable, bamboo shoots, hops, potato, paddy rice, pepper, apple, banana, citrus, peach, papaya, orchid, potted landscape, the applicable mite of composition evil is phytophagy evil mite, and it is that the harmful mite of Tetranychidae, Tenuipalpidae, furan line mite, Eriophyidae is that Panonychus citri belongs to, tetranychus telarius belongs to and these global Agricultural Mites of itch mite of Eriophyidae, forestry harmful mites, the harmful mite of gardening and the harmful mite of health that phytophagy evil mite is selected from tetranychid.
Embodiment 9
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and sterilant combination prevent and treat the application in agricultural and forestry and gardening plant disease
All anthranilic diamides derivative Is containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and existing sterilant are as diazosulfide, tiadinil, is abbreviated as TDL, tisocromide, first thiophene lures amine, 4-methyl isophthalic acid, 2,3-thiadiazoles-5-formic acid, 4-methyl isophthalic acid, 2,3-thiadiazoles-5-sodium formiate, 4-methyl isophthalic acid, 2,3-thiadiazoles-5-ethyl formate, DL-beta-aminobutyric acid, isotianil, it is English general by name: isotianil, 3,4-, bis-chloroisothiazoles-5-formic acid, 3,4-, bis-chloroisothiazoles-5-sodium formiate, 3,4-, bis-chloroisothiazoles-5-ethyl formate, virazole, antofine, Ningnanmycin or Whitfield's ointment, frost urea cyanogen, thiram, ziram, zinc manganese ethylenebisdithiocarbamate, phosethyl Al, thiophanate_methyl, m-tetrachlorophthalodinitrile, enemy can be loose, procymidone, fenpropidin, thiophanate methyl, thiophanate, Metalaxyl-M, flumorph, dimethomorph, efficient metaxanin, efficient M 9834, two chlorine zarilamids, flusulfamide, first flusulfamide, thiophene fluorine bacterium amine, fultolanil, tecloftalam, ring propionyl bacterium amine, cyflufenamid, fenhexamid, zarilamid, Silthiopham, furametpyr, pyrrole metsulfovax, mandipropamid, zoxamide, fenfuram, carboxin, chlozolinate, RP-26019, Azoxystrobin, dimoxystrobin, fluoxastrobin, kresoxim-methyl, SSF 126, orysastrobin, ZEN 90160, Strobilurin, oxime bacterium ester, enostroburin, alkene oxime amine, oxygen ring azoles, bromuconazole, SN-108266, difenoconazole, alkene azoles alcohol, efficient alkene azoles alcohol, epoxiconazole, RH-7592, fluquinconazole, fluzilazol, flutriafol, own azoles alcohol, imibenconazole, plant bacterium azoles, metconazole, nitrile bacterium azoles, Topaze, Wocosin 50TK, prothioconazoles, simeconazoles, tebuconazole, tertraconazole, triadimenol, triticonazole, bitertanol, thiabendazole, fuberidazole, imazalil, efficient imazalil, prochloraz, fluorine bacterium azoles, cyazofamid, fenamidone, Evil imidazoles, pefurazoate, famoxadone, SYP-Z048, hymexazo, the spirit of Evil frost, Guardian, etridiazole, octhilinone, benthiozole, dodemorph, fenpropimorph, tridemorph, fenpiclonil, fludioxonil, fluazinam, pyrifenox, ring pyridine bacterium amine, boscalid amine, fluopicolide, pyridine bacterium amine, cyprodinil, fluorine mepanipyrim, ferimzone, mepanipyrim, phonetic mould amine, fenarimol, nuarimol, chinomethionate, dithianon, ethoxyquin, hydroxyquinoline, the third oxygen quinoline, benzene oxygen quinoline, the mould prestige of second, iprovalicarb, benzene metsulfovax, Propamocarb, methasulfocarb, edifenphos, iprobenfos, pyrazophos, tolclofosmethyl, miewensu, kasugamycin, polyoxin, Polyoxin, validamycin, jingganmycin, Streptomycin sulphate, metaxanin, furalaxyl, M 9834, ofurace, mebenil, derosal, F-1991, thiophanate_methyl, triazolone, bupirimate, dimethirimol, the phonetic phenol of second, Difolatan, Vancide 89, Phaltan, Vinclozoline, fluoromide, dimetachlone, m-tetrachlorophthalodinitrile, isoprothiolane, Kitazine, bismerthiazol, quintozene, zinc 1,2-propylene bisdithiocarbamate, fosetylaluminium, sulphur, Bordeaux mixture, copper sulfate, copper oxychloride, Red copper oxide, copper hydroxide, metrafenone, pencycuron, diclomezin, phthalide, pyroquilon, volution bacterium amine, tricyclazole, triforine, the pyridine of many fruits, the pungent salt of biguanides, iminoctadine, dicloran, benzene flusulfamide, toluene flusulfamide, K-281, fenaminosulf, oxolinic acide, probenazole, bronopol, methyl iodide, metamsodium, enemy's line ester, dazomet, dichloroisopropyl ether, lythidathion, cadusafos, fensulfothion, thionazin, fenamiphos, ethoprophos, dichlofenthion, isazofos, fosthietan, oxamyl, aldicarb, carbofuran, sulfuryl fluoride, dichloropropylene, dichloro-isonicotinic acid, other known any any one or two kinds that can be used as in sterilant such as allyl isothiazole are used in combination for preventing and treating agricultural and forestry and gardening plant disease, anthranilic diamides derivative I, IA, IB, the total quality percentage composition of IC in composition containing N-cyano group sulfone (sulphur) imines of the present invention is 1%-90%, and the ratio of anthranilic diamides derivative I, IA, IB, IC and aforementioned sterilant containing N-cyano group sulfone (sulphur) imines of the present invention is mass percent 1%: 99% to 99%: 1%, the prevention effect of composition is good, and these compositions have certain synergism and summation action, does not find to have the composition of antagonistic action, above-mentioned composition can be for the control of agricultural plants disease and gardening plant disease, controlling object comprises that more than 20 of the Achylas, Aphanomyces, pythium, phytophthora, Sclerospora, Plasmopara, Pseudoperonospora, Peronospora of Oomycete etc. belong to the diseases that produce, as other diseases of plurality of cereals crop, cash crop, gardening plant and the forestry plants such as seedling blight of rice, tomato root maize ear rot, the late blight of potato, black shank, millet Powdery Mildew, downy mildew of garpe, downy mildew of lettuce, cucumber downy mildew, cucumber anthracnose etc., the formulation of composition processing is selected from sustained release dosage, pulvis, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment emulsion, aqueous emulsion, granule, microemulsion, finish, with the seed of coated pesticidal, suspended emulsion agent, soluble thick agent, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, capsule suspension, dispersible dense dose, missible oil, electrostatic spray agent, water-in-oil emulsion, seed treatment agent, oil-in-water emulsion, smoke candle, granula subtilis, smoke candle, smoke cartridge, smog rod, smog sheet, smoke substance, smog ball, granular poison bait, foaming agent, ointment, thermal fog, solid-liquid mixes dress agent, liquid/liquid mixes dress agent, cold mist agent, Gu Gu/mix filling agent, medicine paint, seed treatment liquor, microgranules, oil suspending agent, finish, oil-dispersing property pulvis, paste, sheet poison bait, dense jelly, sprinkle and water agent, stylus, seed coat agent, poison bait, basting agent, fritter poison bait, suspension agent, suspension emulsion, water-soluble granule, soluble thick agent, film forming finish, tablet, follow the trail of pulvis, ultra low volume liquids, any one in steam releasing agent.These compositions comprise cereal for preventing and treating agricultural and forestry and the applicable plant of gardening plant disease: paddy, wheat, barley, oat, corn, millet, Chinese sorghum; Tuber crops: sweet potato, potato, cassava; Beans: soybean, broad bean, pea, mung bean, red bean and fiber: cotton, crudefiber crop, silkworm and mulberry; Oil plant: peanut, rape, sesame, soybean, Sunflower Receptacle; Sugar material: beet, sugarcane; Beverage: tealeaves, coffee, cocoa; Hobby: tobacco leaf; Medicinal: ginseng, the bulb of fritillary; The torrid zone: rubber, coconut, oil palm, sisal hemp; Food crop and fruit, flowers, oil plant, sugar material and cotton, fiber crops, tea, tobacco, Chinese medicinal materials cash crop and plant melon, really, tea, silkworm and mulberry, vegetables, contain various wild vegetable, bamboo shoots, flowers and ornamental plant, hops, medicinal material, pepper, seedling and other garden crop garden crops as tobacco: flue-cured tobacco, air-curing of tobacco leaves, suncured tabacco; Vegetables, tomato, capsicum, radish, cucumber, Chinese cabbage, celery, hot pickled mustard tube, beet, rape, green onion, garlic, melon: watermelon, muskmelon, hami melon, pawpaw; Beans: soybean, broad bean, pea-pods; Potato, wheat, corn, paddy rice, peanut, fruit tree: apple, banana, citrus, peach, papaya; Flowers: orchid; Potted landscape; Composition has improved the defence capability of plant in sterilization, makes plant produce the defence capability to pathogenic fungi, bacterium and virus infection.
Embodiment 10
Anthranilic diamides derivative I, IA, IB, IC and antiviral agent containing N-cyano group sulfone (sulphur) imines of the present invention is combined in the application preventing and treating in agricultural and forestry and gardening plant virus disease
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and existing Antiphytoviral medicament diazosulfide, tiadinil, be abbreviated as TDL, isotianil, it is English general by name: isotianil, 4-methyl isophthalic acid, 2, 3-thiadiazoles-5-formic acid, 4-methyl isophthalic acid, 2, 3-thiadiazoles-5-sodium formiate, 4-methyl isophthalic acid, 2, 3-thiadiazoles-5-ethyl formate, 3, 4-bis-chloroisothiazoles-5-formic acid, 3, 4-bis-chloroisothiazoles-5-sodium formiate, 3, 4-bis-chloroisothiazoles-5-ethyl formate, DL-beta-aminobutyric acid, virazole, antofine, Ningnanmycin, tisocromide, first thiophene lures amine or Whitfield's ointment, cytosintetidemycin, dichloro-isonicotinic acid, allyl isothiazole, well ridge azanol, in jingganmycin, any 1 or 2 compound combinations are used for preventing and treating agricultural and forestry and gardening plant virus disease, the disease of control agricultural and forestry and gardening plant virus disease is selected from tobacco mosaic virus disease, various melon virus diseases, various solanaceous vegetables virus diseases, beans virus disease, Cruciferae virus disease, grain and oil crop virus disease, any in cotton virus disease and various fruit tree virus disease, wherein endanger serious being selected from: tobacco virus, peppery pimento virus disease, tomato virus disease, Chinese cabbage virus disease, Virus Diseases of Rice comprises rice dwarf virus disease, yellow dwart, stripe virus disease, fern leaf of tomato viral disease, pepper mosaic virus disease viral disease and tobacco veinal necrosis virus disease, maize dwarf mosaic, cauliflower mosaic virus, oranges and tangerines virus disease, cymbidium mosaic virus, any in cybidium ring spot virus.These compositions are selected from paddy for the plant that prevents and treats agricultural and forestry and gardening plant virus disease, wheat, barley, oat, corn, Chinese sorghum, sweet potato, potato, cassava, soybean, pea-pods, broad bean, pea, mung bean, red bean, cotton, silkworm and mulberry, peanut, rape, sesame, Sunflower Receptacle, beet, sugarcane, coffee, cocoa, ginseng, the bulb of fritillary, rubber, coconut, oil palm, sisal hemp, tobacco, tomato, capsicum, radish, cucumber, Chinese cabbage, celery, hot pickled mustard tube, beet, rape, green onion, garlic, watermelon, muskmelon, hami melon, pawpaw, really, tea, wild vegetable, bamboo shoots, hops, potato, paddy rice, pepper, apple, banana, citrus, peach, papaya, orchid, the agriculturals such as potted landscape, gardening, economical, the plants such as forestry, the use of these compositions improves the immunizing power of crop self, in producing the control of insect especially infection insect, has induced plant to produce the defence capability to viral diseases of plants, also can produce the direct prevention effect of virus disease, therefore, these compositions can be for preparation and the purposes of Antiphytoviral medicament and inducing plant Antiphytoviral medicament.Anthranilic diamides derivative I, IA, IB, the total quality percentage composition of IC in composition containing N-cyano group sulfone (sulphur) imines of the present invention is 1%-90%, and the ratio of anthranilic diamides derivative I, IA, IB, IC and aforementioned Antiphytoviral medicament containing N-cyano group sulfone (sulphur) imines of the present invention is mass percent 1%: 99% to 99%: 1%, the formulation of composition processing is selected from sustained release dosage, pulvis, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment emulsion, aqueous emulsion, granule, microemulsion, finish, with the seed of coated pesticidal, suspended emulsion agent, soluble thick agent, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, capsule suspension, dispersible dense dose, missible oil, electrostatic spray agent, water-in-oil emulsion, seed treatment agent, oil-in-water emulsion, smoke candle, granula subtilis, smoke candle, smoke cartridge, smog rod, smog sheet, smoke substance, smog ball, granular poison bait, foaming agent, ointment, thermal fog, solid-liquid mixes dress agent, liquid/liquid mixes dress agent, cold mist agent, Gu Gu/mix filling agent, medicine paint, seed treatment liquor, microgranules, oil suspending agent, finish, oil-dispersing property pulvis, paste, sheet poison bait, dense jelly, sprinkle and water agent, stylus, seed coat agent, poison bait, basting agent, fritter poison bait, suspension agent, suspension emulsion, water-soluble granule, soluble thick agent, film forming finish, tablet, follow the trail of pulvis, ultra low volume liquids, any one in steam releasing agent, between these compositions, all show and be added or synergism, in keeping insecticidal activity, its antiviral activity is all greater than the effect that any one compound uses separately, find no the composition of antagonistic action, the drug effect lasting period of composition is long.
Embodiment 11
Complete processing and the stability of anthranilic diamides derivative I, IA, IB, IC and aforementioned sterilant, sterilant, anti-plant virus agent and activating plants agent compound preparation containing N-cyano group sulfone (sulphur) imines of the present invention
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and aforementioned sterilant, sterilant, the mixture complete processing of anti-plant virus agent and activating plants agent is in table 5, from table 5, most medicament all can be processed according to the method for statement, the main component of liquid preparation is effective constituent and solubility promoter and tensio-active agent, synergistic agent, antifreezing agent, stablizer, other the component etc. such as thickening material or permeate agent, the composition of solid preparation mainly includes effect composition, the upper acceptable adjuvant component of other agriculturals such as tensio-active agent and filler, the cold storage test of process preparation, liquid preparation is placed 1 week without Precipitation at 0 ± 2 degree Celsius, solid preparation is placed 2 weeks at 54 ± 2 degrees Celsius, there is not caking phenomenon in medicament, all preparations store the medicament drug effect of placing front and back without significant difference, the rate of decomposition of composition effective constituent is in 5%, composite preparation qualified stability.
The insecticidal activity (mythimna separata, 48h mortality ratio/%) of the table 2 anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC
Sequence number Compound 5.0 ug/ml 1.0 ug/ml 0.1 ug/ml
1 Hxw002-45 100 20 0
2 Hxw003-5 100 0 0
3 Hxw003-8 100 0 0
4 Hxw003-9 100 20 0
5 Hxw003-10 40 ND ND
6 Hxw003-15 70 0 0
7 Hxw003-18 100 0 0
8 Hxw003-21 100 40 0
9 Hxw003-24 100 0 0
10 Mt007-36-1 100 0 0
11 Mt007-37-1 70 0 0
12 Mt007-41-1 100 0 0
13 Hxw003-20 100 50 0
14 Hxw003-23 100 0 0
15 Hxw003-26 100 0 0
16 Hxw003-22 100 0 0
17 Hxw003-25 60 ND ND
18 Hxw003-27 100 20 0
19 Lfy001-8-1 100 70 0
20 Mt007-46-1 100 100 0
21 Mt007-47-1 100 0 0
22 Zgn001-14-1 100 50 0
23 Mt007-44-1 100 0 0
24 Mt007-45-1 100 0 0
25 Mt007-50-1 80 0 ND
26 Cyanogen insect amide 100 100 0
27 Provado 20 0 0
ND: undetermined.
Insecticidal activity (small cabbage moth 72h mortality ratio/% of the table 3 anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC; Aphid 48h mortality ratio/%)
Table 4 is containing the fungicidal activity (/ %) of the anthranilic diamides derivative I of N-cyano group sulfone (sulphur) imines, IA, IB, IC
Numbering Compound number AS CA GZ PP BC SS RC PS PI
1 Hxw002-45 21.74 10.53 16.28 44.64 4.17 62.07 36.54 22.62 23.33
2 Hxw003-5 6.06 10.71 17.07 28.57 42.31 42.11 33.33 14.29 9.68
3 Hxw003-8 30.43 26.32 13.95 41.07 25.00 20.69 38.46 15.48 6.67
4 Hxw003-9 30.43 21.05 13.95 50.00 37.50 17.24 48.08 19.05 10.00
5 Hxw003-10 30.43 26.32 13.95 41.07 25.00 20.69 38.46 15.48 6.67
6 Hxw003-15 21.74 10.53 16.28 44.64 4.17 62.07 36.54 22.62 23.33
7 Hxw003-18 6.06 17.86 9.76 41.07 61.54 63.16 29.82 15.48 12.90
8 Hxw003-21 12.12 10.71 12.20 26.79 7.69 57.89 33.33 9.52 12.90
9 Hxw003-24 26.09 5.26 20.93 51.79 4.17 86.21 28.85 20.24 6.67
10 Mt007-36-1 19.05 18.52 35.71 42.42 45.71 68.75 62.90 51.85 20.69
11 Mt007-37-1 3.33 0.00 32.26 74.29 50.00 23.68 36.00 62.50 21.74
12 Mt007-41-1 14.29 3.70 35.71 36.36 8.57 56.25 66.13 49.38 20.69
13 Hxw003-20 9.09 7.14 4.88 32.14 50.00 52.63 38.60 5.95 16.13
14 Hxw003-23 9.09 7.14 4.88 32.14 50.00 52.63 38.60 5.95 16.13
15 Hxw003-26 6.06 14.29 14.63 28.57 34.62 63.16 19.30 8.33 12.90
16 Hxw003-22 30.43 26.32 13.95 41.07 25.00 20.69 38.46 15.48 6.67
17 Hxw003-25 30.43 5.26 16.28 53.57 12.50 6.90 32.69 27.38 6.67
18 Hxw003-27 15.15 3.57 4.88 28.57 26.92 52.63 33.33 10.71 6.45
19 Lfy001-8-1 17.24 12.50 25.00 50.00 65.79 73.53 64.06 53.66 23.68
20 Mt007-46-1 6.67 4.35 25.81 40.00 43.33 52.63 44.00 64.06 21.74
21 Mt007-47-1 12.50 22.22 14.71 29.31 31.71 29.17 45.45 45.59 22.22
22 Zgn001-14-1 14.29 11.11 39.29 48.48 45.71 62.50 59.68 48.15 10.34
23 Mt007-44-1 9.52 14.81 17.86 36.36 40.00 53.13 66.13 50.62 24.14
24 Mt007-45-1 50.00 8.70 41.94 41.43 20.00 18.42 32.00 48.44 26.09
Data are the measurement result of 50 ug/ml; AS: tomato early blight bacterium (Alternaria solani); BC: botrytis cinerea pers (Botrytis cinerea); CA: peanut Cercospora bacteria (Cercospora arachidicola); GZ: fusarium graminearum (Gibberella zeae); PI: phytophthora infestans (Phytophthora infestans (Mont.) de Bary); PP: Botryosphaeria berengeriana f. sp (Physalospora piricola); PS: Rhizoctonia solani Kuhn (Pellicularia sasakii); RC: Rhizoctonia cerealis (Rhizoctonia cerealis); SS: Sclerotinia sclerotiorum (Sclerotinia sclerotiorum); ND: undetermined.
The working method of anthranilic diamides derivative I, IA, IB, IC and aforementioned Insecticidal and acaricidal agent, sterilant and the Antiphytoviral pharmacy mix of table 5 N-cyano group of the present invention sulfone (sulphur) imines

Claims (10)

1. the anthranilic diamides derivative of class N-cyano group sulfone (sulphur) imines, is characterized in that having the chemical structure of general formula suc as formula shown in I:
Wherein, X is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; Y is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; R 1be selected from: substituted alkyl, replacement unsaturated alkyl, methylthio group substituted alkyl, methylthio group replace unsaturated alkyl, cyano group, substituted sulphonyl, substituted-amino formyl radical; Preferred: X is selected from: chlorine, bromine; Y is selected from: chlorine, bromine; R 1be selected from: 2-methylmercaptoethyl, 2-((N-cyano group) methyl sulfilimine base) ethyl, 2-((N-cyano group) methyl sulfone imido grpup) ethyl, the 2-methylthio group tertiary butyl, 2-((N-cyano group) the methyl sulfilimine base) tertiary butyl, 2-((N-cyano group) methyl sulfone imido grpup) tertiary butyl.
2. the anthranilic diamides derivative of class N-cyano group sulfone (sulphur) imines, is characterized in that having the chemical structure of general formula suc as formula shown in IA:
X is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; Y is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; R 2be selected from: H, substituted alkyl, replacement unsaturated alkyl, substituted aryl; X is preferred: Cl, Br; Y is preferred: Cl, Br; R 2preferred: H, CH 3.
3. the anthranilic diamides derivative of class N-cyano group sulfone (sulphur) imines, is characterized in that having the chemical structure of general formula suc as formula shown in IB:
X is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; Y is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; R 2be selected from: H, substituted alkyl, replacement unsaturated alkyl, substituted aryl; X is preferred: Cl, Br; Y is preferred: Cl, Br; R 2preferred: H, CH 3.
4. the anthranilic diamides derivative of class N-cyano group sulfone (sulphur) imines, is characterized in that having the chemical structure of general formula suc as formula shown in IC:
X is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; Y is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; R 2be selected from: H, substituted alkyl, replacement unsaturated alkyl, substituted aryl; X is preferred: Cl, Br; Y is preferred: Cl, Br; R 2preferred: H, CH 3.
5. the class described in claim 1,2,3,4 is containing the synthetic method of the anthranilic diamides derivative I of N-cyano group sulfone (sulphur) imines, IA, IB, IC, and concrete synthetic route is as follows:
Wherein, X is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; Y is selected from: halogen, CN, NO 2, NH 2, substituted alkyl, replacement unsaturated alkyl; R 2be selected from: H, substituted alkyl, replacement unsaturated alkyl, substituted aryl; X is preferred: chlorine, bromine; Y is preferred: chlorine, bromine; R 2preferred: H, CH 3;
Specifically be divided into following steps:
A. replace the preparation of benzoxazine IV:
In 50 milliliters of round-bottomed flasks, add 15 milliliters of acetonitriles, 1.0 mmole 3-replacement-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II, 5 mmole Methanesulfonyl chlorides, be abbreviated as the i.e. 5 mmole pyridines of MsCl, 0.4 gram, be abbreviated as Py, be cooled to-5 degrees Celsius, stirring after 30 minutes adds 1.0 mmoles to replace anthranilic acid, slowly rise to after room temperature and stir and spend the night, having yellow solid to replace benzoxazine IV separates out, filter, washing, vacuum-drying, is directly used in next step reaction, described 3-replacement-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II is selected from the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid, the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid, described replacement benzoxazine IV is selected from 2-(the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl) the chloro-4-oxo-4H-of-8-methyl-6-benzo-[d] [1, 3]-oxazines, 2-(the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl) the bromo-4-oxo-4H-of-8-methyl-6-benzo-[g] [1, 3]-oxazines, 2-(the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl) the chloro-4-oxo-4H-of-8-methyl-6-benzo-[d] [1, 3]-oxazines, 2-(the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-yl) the bromo-4-oxo-4H-of-8-methyl-6-benzo-[d] [1, 3]-oxazines,
B.1-the preparation of (3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-(methylthio group alkyl) amido formacyl) aniline IA:
In 50 milliliters of round-bottomed flasks, add 0.5 mmole to replace benzoxazine IV, 20 milliliters of tetrahydrofuran (THF)s, be abbreviated as the replacement methylmercaptan ethyl ammonia of THF, 5.0 mmoles, reaction mixture stirring at room temperature 7 hours; Concentrating under reduced pressure is except desolventizing, gained resistates obtains yellow or white solid 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-(methylthio group alkyl) amido formacyl) aniline IA through 200～300 order purification by silica gel column chromatography, eluent is the sherwood oil of 60～90 degrees Celsius: ethyl acetate, and volume ratio is 3: 1; With gained sterling calculated yield, yield 40-70%; The amount of synthetic compound expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles; described 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-(methylthio group alkyl) amido formacyl) aniline IA is selected from the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline, the fluoro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(methylmercaptoethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-(the methylthio group tertiary butyl) amido formacyl) aniline,
C.1-the preparation of (3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfilimine base) alkyl) amido formacyl) aniline IB:
In 50 milliliters of round-bottomed flasks, add 0.5 mmole 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-(methylthio group alkyl) amido formacyl) aniline IA, 15 milliliters of dry methylene dichloride, ice-water bath is cooled to 0 degree Celsius; Then add respectively 1.0 mmole cyanamides and 0.5 mmole acetic acid iodobenzene, at this temperature, stir stirred overnight at room temperature after 3 hours, the 2nd day by direct reaction solution removal of solvent under reduced pressure, resistates obtains faint yellow or white solid 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfilimine base) alkyl) amido formacyl) aniline IB through 200～300 order purification by silica gel column chromatography, eluent is ethyl acetate, with gained sterling calculated yield, yield 40-60%; The amount of synthetic compound expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles; described 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfilimine base) alkyl) amido formacyl) aniline IB is selected from the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfilimine base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfilimine base) tertiary butyl) amido formacyl) aniline,
D.1-the preparation of (3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfoximide base) alkyl) amido formacyl) aniline IC:
In 50 milliliters of three mouthfuls of round-bottomed flasks, add 1.0 mmole metachloroperbenzoic acids, write a Chinese character in simplified form m-CPBA, 8 milliliters of ethanol, ice-water bath is cooled to 0 degree Celsius and stirs 10 minutes, then by 1.5 mmole Anhydrous potassium carbonates 7 ml water solution is disposable adds, have a large amount of white solids to separate out; 0 degree Celsius of stirring dropwise added 8 milliliters of ethanolic solns of 0.5 mmole 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfilimine base) alkyl) amido formacyl) aniline IB after 20 minutes, stirred and after 1 hour, reaction solution was quenched in water; Then with 50 milliliters of ethyl acetate extractions three times, saturated common salt water washing 2 times for organic layer, anhydrous magnesium sulfate drying, removal of solvent under reduced pressure, resistates obtains faint yellow or white solid 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfoximide base) alkyl) amido formacyl) aniline IC through 200～300 order purification by silica gel column chromatography, eluent is the sherwood oil of 60～90 degrees Celsius: ethyl acetate, according to the difference of product, volume ratio is between 1: 1～1: 3; With gained sterling calculated yield, yield 50-70%; The amount of synthetic compound expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles; described 1-(3-chloropyridine-2-yl)-3-halo-1H-pyrazoles-5-formyl-2-methyl-4-halo-6-(2-((N-cyano methyl sulfoximide base) alkyl) amido formacyl) aniline IC is selected from the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the chloro-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the chloro-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((N-cyano methyl sulfoximide base) ethyl) amido formacyl) aniline, the bromo-6-of 1-(3-chloropyridine-2-yl) the bromo-1H-pyrazoles-5-of-3-formyl-2-methyl-4-(2-((the N-cyano methyl sulfoximide base) tertiary butyl) amido formacyl) aniline,
In the time of X=halogen, substituted pyrazolecarboxylic-5-formic acid II is synthetic by the method for following route:
E.2-the preparation of diazanyl substituted pyridines VI:
By 50 mmoles 2, hydrazine hydrate, 50 milliliters of ethanol of 3-chloropyridine V, 100 mmoles join in 100 milliliters of three mouthfuls of round-bottomed flasks, 80 degrees Celsius of lower reflux 20 hours, remove solvent under reduced pressure, gained solid obtains intermediate 2-diazanyl substituted pyridines VI with ethyl alcohol recrystallization, with gained sterling calculated yield, yield 91%; The amount of synthetic 2-diazanyl substituted pyridines VI expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles;
F.2-the preparation of (3-chloropyridine-2-yl)-5-oxopyrazoline alkane-3-ethyl formate VII:
In 100 milliliters of reaction flasks, add 50 milliliters of ethanol, slowly add the sodium Metal 99.5 of 55 mmoles, back flow reaction is made alcohol sodium solution. under reflux state, add the ethyl maleate of 50 mmole 2-diazanyl substituted pyridines VI, 60 mmoles, continue to reflux 30 minutes, then cooling, filters, and gained solid obtains yellow solid 2-(3-chloropyridine-2-yl)-5-oxopyrazoline-3-ethyl formate VII by cold washing with alcohol, with gained sterling calculated yield, yield 70%; The amount of synthetic 2-(3-chloropyridine-2-yl)-5-oxopyrazoline-3-ethyl formate VII expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles;
G.3-halo-1-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate VIII's is synthetic
To adding 5.4 grams of i.e. 20 mmole 2-(3-chloropyridine-2-yl)-5-oxopyrazoline-3-ethyl formate VII, 50 milliliters of acetonitriles, 30 mmole three oxyhalogen phosphorus, stirring and refluxing 3 hours in 100 milliliters of single necked round bottom flask; Concentrate and remove most of solvent, resistates is dissolved in methylene dichloride, use successively saturated sodium bicarbonate aqueous solution and saturated common salt water washing, anhydrous sodium sulfate drying is concentrated, thick product obtains yellow oil VIII through 200～300 order purification by silica gel column chromatography, eluent is the sherwood oil of 60～90 degrees Celsius: ethyl acetate, and volume ratio is 3: 1; With gained sterling calculated yield, yield 80-90%; Synthetic 3-halo-1-(3-chloropyridine-2-yl)-4, the amount of 5-dihydro-1 h-pyrazole-5-ethyl formate VIII expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles; Described three oxyhalogen phosphorus are selected from phosphorus oxychloride, tribromo oxygen phosphorus; Described 3-halo-1-(3-chloropyridine-2-yl)-4, the VIII of 5-dihydro-1 h-pyrazole-5-ethyl formate is selected from the chloro-1-of 3-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate, the bromo-1-of 3-(3-chloropyridine-2-yl)-4,5-dihydro-1 h-pyrazole-5-ethyl formate;
H.3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate IX's is synthetic
In 100 milliliters of reaction flasks, add the 30 mmole 3-halo-1-(3-chloropyridine-2-yl)-4 of above-mentioned preparation, 5-dihydro-1 h-pyrazole-5-ethyl formate VIII, 50 milliliters of acetonitriles, slowly add 3 milliliters of vitriol oils, then add the Potassium Persulphate of 40 mmoles, reflux 3 hours, then cooling, pours into and in frozen water, filters to obtain yellow solid 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate IX, with gained sterling calculated yield, yield 65-75%; The amount of synthetic compound expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles; Described 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate IX is selected from the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate, the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate;
I.3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II's is synthetic
To adding successively 1.0 grams of i.e. i.e. 5.0 mmole sodium hydroxide of 3.0 mmole 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-ethyl formate, 10 ml methanol, 0.2 gram, stirring at room temperature 8 hours in 50 milliliters of single necked round bottom flask; After TLC monitoring reaction finishes, concentratedly remove most of solvent, add 20 milliliters of frozen water, the aqueous solution wash once by ethyl acetate, is acidified to pH=4 with 2 mol/L dilute hydrochloric acid, and adularescent solid generates, filtration, and filter cake is washed, and vacuum-drying, obtains faint yellow solid II; The amount of synthetic 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles; Described 3-halo-1-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid II is selected from the chloro-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid, the bromo-1-of 3-(3-chloropyridine-2-yl)-1H-pyrazoles-5-formic acid;
Replace anthranilic acid III synthetic by following method:
Concrete operations are:
J. replace the preparation of anthranilic acid III:
In 100 milliliters of round-bottomed flasks, add 20 mmole 3-methyl-2-amino phenylformic acid X, 50 milliliters of DMF, 30 mmole N-chlorosuccinimide or N-bromosuccinimides, after return stirring 3 hours, reaction solution is poured in frozen water, dilute hydrochloric acid is acidified to pH=6, filter, gained precipitation obtains gray solid by a small amount of washing with alcohol and replaces anthranilic acid III, and by gained sterling calculated yield, yield is greater than 83%; The synthetic amount that replaces anthranilic acid III expands or dwindles by corresponding proportion; The volume of respective reaction container expands in proportion or dwindles; Described replacement anthranilic acid III is selected from 2-amido-3-methyl-5-chloro phenylformic acid, 2-amido-3-methyl-5-bromo-benzoic acid.
6. the upper acceptable auxiliary agent of the anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines described in claim 1,2,3,4, IA, IB, IC and agricultural is in the purposes of preparing in sterilant.
7. the upper acceptable auxiliary agent of the anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines described in claim 1,2,3,4, IA, IB, IC and agricultural is in the purposes of preparing in sterilant.
8. the upper acceptable auxiliary agent of the anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines described in claim 1,2,3,4, IA, IB, IC and agricultural is in the purposes of preparing in anti-plant virus agent.
9. described in claim 1,2,3,4, prevent and treat the application in doing harm to of agricultural and forestry and gardening plant insect pest, mite containing the anthranilic diamides derivative I of N-cyano group sulfone (sulphur) imines, IA, IB, IC and Insecticidal and acaricidal agent combination:
Anthranilic diamides derivative I, IA, IB, IC and insecticide composition containing N-cyano group sulfone (sulphur) imines of the present invention prevented and treated the application in agricultural and forestry and gardening plant insect pest:
All anthranilic diamides derivative Is containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and existing sterilant: Chlorpyrifos 94, the sub-Nong in ground, acetamiprid, Affirm (Merck Co.), milbemectin, Avrmectin, pleocidin, fenvalerate, efficient fenvalerate, Cypermethrin, effective cypermethrin, lambda-cyhalothrin, Deltamethrin, Fenvalerate, Beta-cyfloxylate, cyfloxylate, Lambda-lambda-cyhalothrin, Permanone, permethrin, esbiothrin, cyhalothrin, bifenthrin, permethrin, ether chrysanthemum ester, flumethrin, fluvalinate, Provado, acetamiprid, Ti304, imidaclothiz, thiacloprid, Diacloden, clothianidin, MTI-446, clothianadin, Da Tenan, diflubenzuron, young urea goes out, Teflubenzuron, deinsectization is grand, HEXAFLUMURON, flufenoxuron, pyridine worm is grand, lufenuron, poisonous insect urea, penfluron, Noviflumuron is noviflumuron, and it is for No. CAS 121451-02-3, flucycloxuron, Novaluron is Rimon, fluorine pyridine urea, i.e. { 1-[(3.5-bis-chloro-4) 4-nitrophenoxy phenyl 3-3-(2-chlorobenzene)-urea } of Bay sir 6874, Bay SIR-8514 i.e. [1-(4-Trifluoromethoxyphen-l)-3-(2-chlorobenzene)-urea], piperazine worm urea, Bistrifluron is bistrifluron, furan tebufenozide, worm hydrazides, chlorine worm hydrazides, methoxyfenozide, ring worm hydrazides, Rogor, omethoate, SD-1750, acephate, triazophos, Resitox, pyridaphenthione, isazofos, Ro 7-5050, SevinCarbaryl, Aphox, meta-tolyl-N-methylcarbamate (MTMC), isoprocarb, cartap, fenobucarb, leaf disperses, carbaryl, benfuracarb, carbosulfan, cartap, bromopropylate, hexythiazox, fenpyroximate, pyridaben, clofentezine, propargite, diafenthiuron, benfuracarb, pymetrozine, spiral shell mite ester, spiral shell worm ester, spiral shell worm ethyl ester, butene-fipronil, azocyclotin, Buprofezin, ethoprophos, ethiprole, desinsection list, disosultap, chlorantraniliprole, Flubendiamide, fluorine cyanogen insect amide, cyanogen insect amide, Tolfenpyrad, tebufenpyrad, bromothalonil, pyrazinones, second mite azoles, tebufenpyrad, the young ketone of rattling away, Nylar, any one in emaricin or two kinds are used in combination for preventing and treating agricultural and forestry and gardening plant insect pest, anthranilic diamides derivative I, IA, IB, the quality percentage composition of IC in composition containing N-cyano group sulfone (sulphur) imines of the present invention is 1%-90%, and the ratio of anthranilic diamides derivative I, IA, IB, IC and aforementioned sterilant containing N-cyano group sulfone (sulphur) imines of the present invention is mass percent 1%: 99% to 99%: 1%, can directly be watered rear spraying, comprise the upper acceptable solvent of agricultural and emulsifying agent and solubility promoter and synergistic agent in the preparation of composition, the formulation of composition processing is selected from sustained release dosage, pulvis, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment emulsion, aqueous emulsion, granule, microemulsion, finish, with the seed of coated pesticidal, suspended emulsion agent, soluble thick agent, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, capsule suspension, dispersible dense dose, missible oil, electrostatic spray agent, water-in-oil emulsion, seed treatment agent, oil-in-water emulsion, smoke candle, granula subtilis, smoke candle, smoke cartridge, smog rod, smog sheet, smoke substance, smog ball, granular poison bait, foaming agent, ointment, thermal fog, solid-liquid mixes dress agent, liquid/liquid mixes dress agent, cold mist agent, Gu Gu/mix filling agent, medicine paint, seed treatment liquor, microgranules, oil suspending agent, finish, oil-dispersing property pulvis, paste, sheet poison bait, dense jelly, sprinkle and water agent, stylus, seed coat agent, poison bait, basting agent, fritter poison bait, suspension agent, suspension emulsion, water-soluble granule, soluble thick agent, film forming finish, tablet, follow the trail of pulvis, ultra low volume liquids, any one in steam releasing agent, the insect pest that can prevent and treat mainly contains red spider, Asiatic migrotory locust, clouding car locust, Chinese rice grasshopper, Patanga japonica (l.Bol.), single thorn mole cricket, east mole cricket, rice thrips, onion thrips, greenhouse thrips, haplothrips aculeatus, Mai Jian pipe thrips, Trialeurodes vaporariorum Westwood, Bemisia tabaci, rice green leafhopper, green leaf hopper, chlorita biguttula, spot clothing plant hopper, brown paddy plant hopper, white backed planthopper, small brown rice planthopper, the flat angle of sugarcane plant hopper, cotten aphid, green bugs, grain aphid, black peach aphid, kaoliang aphid, radish aphid, icerya purchasi, Pseudaulacaspis pentagona, unaspis shield kuwana, san jose scale, wax insect, ceroplastes rubens, Didesmococcus koreanus Borchs, pear lace bug, banana lace bug, thin corner piece stinkbug, Orius minutus, slender rice bug, paddy fly, niphe elongata, scotinophora lurida, Nezara viridula smaragdula Fabricius., green plant bug, alfalfa plant bug, black striped plant bug, chrysopa septempunctata, beautiful Chrysopa, Chinese green lacewing, rain moth, casemaking clothes moth, cnidocampa flavescens walker, brown slug moth, thosea siensis, gelechiid, pink bollworm, brachmia triannuella, small cabbage moth, small heart-eating peach worm, eating-core bean worm, small heart-eating peach worm, apple Spilonota lechriaspis, brown belt length leaf roller, Adoxophyes cyrtosema, striped rice borer, bean-pod borer, Pyrausta nubilalis (Hubern)., yellow rice borer, Oeobia undalis, Cnaphalocrocis medinali(rice leaf roller), bar snout moth's larva, the wild snout moth's larva of lap leaf, dichocrocis punctiferalis, armyworm, prodenia litura, rice green caterpillar, anomis flava, beet armyworm, pink rice borer, bollworm, ancient cooking vessel point diamond drill, black cutworm, large cutworm, yellow cutworm, steal poison moth, gypsymoth, palaearctic sweet potato, greenish brown hawk moth, straight burr rice hesperiidae, pelopidas mathias, oranges and tangerines swallowtail butterfly, Common Mormon, small white, pyrameis indica, the yellow a kind of butterfly harmful to crop plants of ramie, beans blister beetle, Venus ground beetle, wrinkle sheath ground beetle, wheat head ground beetle, pleonomus canaliculatus, Agriotes subrittatus Motschulsky, khapra beetle, attagenus piceus, the little buprestid beetle of oranges and tangerines, gold edge buprestid beetle, tenebrio molitor, dark mealworm, red flour beetle, confused flour beetle, verdigris different beetle, H. parallela, holotrichia oblita, mulberry borer, longicorn beetle, nadezhdiella cantori, pink neck longicorn, large daikon leaf beetle, daicon leaf beetle, aulacophora femoralis, Phyllotreta striolata, Callosobruchus chinensis, pea weevil, broad bean weevil, sitophilus zea-mais, rice weevil, dolerus tritici, pear fruit sawfly, yellowish leukorrhea ichneumon wasp, armyworm white star ichneumon wasp, corn earworm is hanged cocoon ichneumon wasp, bollworm tooth lip ichneumon wasp, snout moth's larva stain wart ichneumon wasp, mosquito, fly, horsefly, wheat midge, contarinia tritici, pachydiplosis oryzae, citrus fruit fly, melon trypetid, the latent fly of wheat leaf ash, Americal rice leaf miner, the black latent fly of beans stalk, frit fly, plant fly, onion fly, radish fly, full skirt chases after posts fly, Pyrausta nubilalis (Hubern). is strict posts fly, armyworm lacks must post fly Agricultural pests, forestry pest, gardening pest insect and sanitary insect pest, controlling mode also comprises double controlling simultaneously, the prevention effect of composition is good, and drug effect plays stably, and has certain synergism and summation action, does not find to have the composition of antagonistic action, in these composition for preventing and controlling agricultural and forestry and gardening plant insect pest, comprise paddy, wheat, barley, oat, corn, Chinese sorghum, sweet potato, potato, cassava, soybean, pea-pods, broad bean, pea, mung bean, red bean, cotton, silkworm and mulberry, peanut, rape, sesame, Sunflower Receptacle, beet, sugarcane, coffee, cocoa, ginseng, the bulb of fritillary, rubber, coconut, oil palm, sisal hemp, tobacco, tomato, capsicum, radish, cucumber, Chinese cabbage, celery, hot pickled mustard tube, beet, rape, green onion, garlic, watermelon, muskmelon, hami melon, pawpaw, really, tea, wild vegetable, bamboo shoots, hops, paddy rice, pepper, apple, banana, citrus, peach, papaya, orchid, potted landscape, composition has improved the defence capability of plant in desinsection, makes plant produce the defence capability to pathogenic fungi, bacterium and virus infection,
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, the combination of IC miticide prevent and treat the application in agricultural and forestry and gardening plant mite evil:
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and the upper acceptable auxiliary agent of agricultural and be selected from azocyclotin, cyhexatin, fenbutatin oxide, three phosphor tins, Zaprawa enolofos, dimethylvinphos, crotoxyphos, SD-1750, heptenopos, Phosdrin, monocrotophos, naled, Chlorpyrifos 94, Pyrimithate, imino-formyl chloride sulphur phosphorus, omethoate, dioxathion, Nialate, Malathion, methacrifos, Phosalone, Volaton, methylpyrimidine sulphur phosphorus, Resitox, sulfotep, triazophos, vamidothion, isocarbophos, acephatemet, propetamphos, dialifos, R-1504, acrinathrin, bifenthrin, cyhalothrin, essence lambda-cyhalothrin, Fenvalerate, flucythrinate, flumethrin, taufluvalinate, brofluthrinate, Bifenazate, fenothiocarb, aldicarb, butocarboxim, oxamyl, Talcord, thiofanox, F-1991, sok, carbofuran, carbosulfan, meta-tolyl-N-methylcarbamate (MTMC), promacyl, formetanate, single carbonamidine, medimeform, amitraz, chlordimeform, peruscabin, bromopropylate, cyflumetofen, acequinocyl, Nissol, flufenoxuron, macro tetrolide, piericidin, thuringiensin, tetranactin, macro tetrolide, Avrmectin, doractin, eprinomectin, ivermectin, selamectin, moxidectin, pyrethrin, nicotine, matrine, nimbin, tubatoxin, tebufenpyrad, pyridaben, fenpyroximate, clofentezine, propargite, hexythiazox, spiral shell mite ester, Fluacrypyrim, Ovotran, propargite, any one in pyridaben or two kinds of medicament combinations are prepared into miticide for preventing and treating agricultural and forestry and gardening plant mite evil, anthranilic diamides derivative I, IA, IB, the total quality percentage composition of IC in composition containing N-cyano group sulfone (sulphur) imines of the present invention is 1%-90%, and the ratio of anthranilic diamides derivative I, IA, IB, IC and above-mentioned medicament containing N-cyano group sulfone (sulphur) imines of the present invention is mass percent 1%: 99% to 99%: 1%, the formulation of composition processing is selected from sustained release dosage, pulvis, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment emulsion, aqueous emulsion, granule, microemulsion, finish, with the seed of coated pesticidal, suspended emulsion agent, soluble thick agent, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, capsule suspension, dispersible dense dose, missible oil, electrostatic spray agent, water-in-oil emulsion, seed treatment agent, oil-in-water emulsion, smoke candle, granula subtilis, smoke candle, smoke cartridge, smog rod, smog sheet, smoke substance, smog ball, granular poison bait, foaming agent, ointment, thermal fog, solid-liquid mixes dress agent, liquid/liquid mixes dress agent, cold mist agent, Gu Gu/mix filling agent, medicine paint, seed treatment liquor, microgranules, oil suspending agent, finish, oil-dispersing property pulvis, paste, sheet poison bait, dense jelly, sprinkle and water agent, stylus, seed coat agent, poison bait, basting agent, fritter poison bait, suspension agent, suspension emulsion, water-soluble granule, soluble thick agent, film forming finish, tablet, follow the trail of pulvis, ultra low volume liquids, any one in steam releasing agent, plant in composition for preventing and controlling agricultural and forestry and gardening plant mite evil is selected from paddy, wheat, barley, oat, corn, Chinese sorghum, sweet potato, potato, cassava, soybean, pea-pods, broad bean, pea, mung bean, red bean, cotton, silkworm and mulberry, peanut, rape, sesame, Sunflower Receptacle, beet, sugarcane, coffee, cocoa, ginseng, the bulb of fritillary, rubber, coconut, oil palm, sisal hemp, tobacco, tomato, capsicum, radish, cucumber, Chinese cabbage, celery, hot pickled mustard tube, beet, rape, green onion, garlic, watermelon, muskmelon, hami melon, pawpaw, really, tea, wild vegetable, bamboo shoots, hops, paddy rice, pepper, apple, banana, citrus, peach, papaya, orchid, potted landscape, the applicable mite of composition evil is phytophagy evil mite, and the harmful mite that is selected from tetranychid and is Tetranychidae, Tenuipalpidae, furan line mite, Eriophyidae is that Panonychus citri belongs to, tetranychus telarius belongs to and these global Agricultural Mites of itch mite of Eriophyidae, forestry harmful mites, the harmful mite of gardening and the harmful mite of health.
10. described in claim 1,2,3,4, prevent and treat the application in agricultural and forestry and gardening plant disease, virus disease with sterilant, anti-plant virus agent combination respectively containing the anthranilic diamides derivative I of N-cyano group sulfone (sulphur) imines, IA, IB, IC:
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and sterilant combination prevent and treat the application in agricultural and forestry and gardening plant disease
All anthranilic diamides derivative Is containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and existing sterilant are as diazosulfide, tiadinil, is abbreviated as TDL, tisocromide, first thiophene lures amine, 4-methyl isophthalic acid, 2,3-thiadiazoles-5-formic acid, 4-methyl isophthalic acid, 2,3-thiadiazoles-5-sodium formiate, 4-methyl isophthalic acid, 2,3-thiadiazoles-5-ethyl formate, DL-beta-aminobutyric acid, isotianil, it is English general by name: isotianil, 3,4-, bis-chloroisothiazoles-5-formic acid, 3,4-, bis-chloroisothiazoles-5-sodium formiate, 3,4-, bis-chloroisothiazoles-5-ethyl formate, virazole, antofine, Ningnanmycin or Whitfield's ointment, frost urea cyanogen, thiram, ziram, zinc manganese ethylenebisdithiocarbamate, phosethyl Al, thiophanate_methyl, m-tetrachlorophthalodinitrile, enemy can be loose, procymidone, fenpropidin, thiophanate methyl, thiophanate, Metalaxyl-M, Whitfield's ointment, flumorph, dimethomorph, efficient metaxanin, efficient M 9834, two chlorine zarilamids, flusulfamide, first flusulfamide, thiophene fluorine bacterium amine, fultolanil, tecloftalam, ring propionyl bacterium amine, cyflufenamid, fenhexamid, zarilamid, Silthiopham, furametpyr, pyrrole metsulfovax, mandipropamid, zoxamide, fenfuram, carboxin, chlozolinate, RP-26019, Azoxystrobin, dimoxystrobin, fluoxastrobin, kresoxim-methyl, SSF 126, orysastrobin, ZEN 90160, Strobilurin, oxime bacterium ester, enostroburin, alkene oxime amine, oxygen ring azoles, bromuconazole, SN-108266, difenoconazole, alkene azoles alcohol, efficient alkene azoles alcohol, epoxiconazole, RH-7592, fluquinconazole, fluzilazol, flutriafol, own azoles alcohol, imibenconazole, plant bacterium azoles, metconazole, nitrile bacterium azoles, Topaze, Wocosin 50TK, prothioconazoles, simeconazoles, tebuconazole, tertraconazole, triadimenol, triticonazole, bitertanol, thiabendazole, fuberidazole, imazalil, efficient imazalil, prochloraz, fluorine bacterium azoles, cyazofamid, fenamidone, Evil imidazoles, pefurazoate, famoxadone, SYP-Z048, hymexazo, the spirit of Evil frost, Guardian, etridiazole, octhilinone, benthiozole, dodemorph, fenpropimorph, tridemorph, fenpiclonil, fludioxonil, fluazinam, pyrifenox, ring pyridine bacterium amine, boscalid amine, fluopicolide, pyridine bacterium amine, cyprodinil, fluorine mepanipyrim, ferimzone, mepanipyrim, phonetic mould amine, fenarimol, nuarimol, chinomethionate, dithianon, ethoxyquin, hydroxyquinoline, the third oxygen quinoline, benzene oxygen quinoline, the mould prestige of second, iprovalicarb, benzene metsulfovax, Propamocarb, methasulfocarb, edifenphos, iprobenfos, pyrazophos, tolclofosmethyl, miewensu, kasugamycin, polyoxin, Polyoxin, validamycin, jingganmycin, Streptomycin sulphate, metaxanin, furalaxyl, M 9834, ofurace, mebenil, derosal, F-1991, thiophanate_methyl, triazolone, bupirimate, dimethirimol, the phonetic phenol of second, Difolatan, Vancide 89, Phaltan, Vinclozoline, fluoromide, dimetachlone, m-tetrachlorophthalodinitrile, isoprothiolane, Kitazine, bismerthiazol, quintozene, zinc 1,2-propylene bisdithiocarbamate, fosetylaluminium, sulphur, Bordeaux mixture, copper sulfate, copper oxychloride, Red copper oxide, copper hydroxide, metrafenone, pencycuron, diclomezin, phthalide, pyroquilon, volution bacterium amine, tricyclazole, triforine, the pyridine of many fruits, the pungent salt of biguanides, iminoctadine, dicloran, benzene flusulfamide, toluene flusulfamide, K-281, fenaminosulf, oxolinic acide, probenazole, bronopol, methyl iodide, metamsodium, enemy's line ester, dazomet, dichloroisopropyl ether, lythidathion, cadusafos, fensulfothion, thionazin, fenamiphos, ethoprophos, dichlofenthion, isazofos, fosthietan, oxamyl, aldicarb, carbofuran, sulfuryl fluoride, dichloropropylene, dichloro-isonicotinic acid, other known any any one or two kinds that can be used as in sterilant of allyl isothiazole are used in combination for preventing and treating agricultural and forestry and gardening plant disease, anthranilic diamides derivative I, IA, IB, the total quality percentage composition of IC in composition containing N-cyano group sulfone (sulphur) imines of the present invention is 1%-90%, and anthranilic diamides derivative I, IA, IB, IC and aforementioned sterilant containing N-cyano group sulfone (sulphur) imines of the present invention, the ratio of anti-plant virus agent are mass percent 1%: 99% to 99%: 1%, the prevention effect of composition is good, and these compositions have certain synergism and summation action, does not find to have the composition of antagonistic action, above-mentioned composition can be for the control of agricultural plants disease and gardening plant disease, controlling object comprises that more than 20 of Achyla, Aphanomyces, pythium, phytophthora, Sclerospora, Plasmopara, Pseudoperonospora, the Peronosporas of Oomycete belong to the disease producing, as other diseases of seedling blight of rice, tomato root maize ear rot, the late blight of potato, black shank, millet Powdery Mildew, downy mildew of garpe, downy mildew of lettuce, cucumber downy mildew, cucumber anthracnose plurality of cereals crop, cash crop, gardening plant and forestry plant, the formulation of composition processing is selected from sustained release dosage, pulvis, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment emulsion, aqueous emulsion, granule, microemulsion, finish, with the seed of coated pesticidal, suspended emulsion agent, soluble thick agent, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, capsule suspension, dispersible dense dose, missible oil, electrostatic spray agent, water-in-oil emulsion, seed treatment agent, oil-in-water emulsion, smoke candle, granula subtilis, smoke candle, smoke cartridge, smog rod, smog sheet, smoke substance, smog ball, granular poison bait, foaming agent, ointment, thermal fog, solid-liquid mixes dress agent, liquid/liquid mixes dress agent, cold mist agent, Gu Gu/mix filling agent, medicine paint, seed treatment liquor, microgranules, oil suspending agent, finish, oil-dispersing property pulvis, paste, sheet poison bait, dense jelly, sprinkle and water agent, stylus, seed coat agent, poison bait, basting agent, fritter poison bait, suspension agent, suspension emulsion, water-soluble granule, soluble thick agent, film forming finish, tablet, follow the trail of pulvis, ultra low volume liquids, any one in steam releasing agent, these compositions comprise cereal for preventing and treating agricultural and forestry and the applicable plant of gardening plant disease: paddy, wheat, barley, oat, corn, millet, Chinese sorghum, tuber crops: sweet potato, potato, cassava, beans: soybean, broad bean, pea, mung bean, red bean and fiber: cotton, crudefiber crop, silkworm and mulberry, oil plant: peanut, rape, sesame, soybean, Sunflower Receptacle, sugar material: beet, sugarcane, beverage: tealeaves, coffee, cocoa, hobby: tobacco leaf, medicinal: ginseng, the bulb of fritillary, the torrid zone: rubber, coconut, oil palm, sisal hemp, food crop and fruit, flowers, oil plant, sugar material and cotton, fiber crops, tea, tobacco, Chinese medicinal materials cash crop and plant melon, really, tea, silkworm and mulberry, vegetables, contain various wild vegetable, bamboo shoots, flowers and ornamental plant, hops, medicinal material, pepper, seedling and other garden crop garden crops as tobacco: flue-cured tobacco, air-curing of tobacco leaves, suncured tabacco, vegetables, tomato, capsicum, radish, cucumber, Chinese cabbage, celery, hot pickled mustard tube, beet, rape, green onion, garlic, melon: watermelon, muskmelon, hami melon, pawpaw, beans: soybean, broad bean, pea-pods, potato, wheat, corn, paddy rice, peanut, fruit tree: apple, banana, citrus, peach, papaya, flowers: orchid, potted landscape, composition has improved the defence capability of plant in sterilization, makes plant produce the defence capability to pathogenic fungi, bacterium and virus infection,
Anthranilic diamides derivative I, IA, IB, IC and anti-plant virus agent containing N-cyano group sulfone (sulphur) imines of the present invention is combined in the application preventing and treating in agricultural and forestry and gardening plant virus disease
Anthranilic diamides derivative I containing N-cyano group sulfone (sulphur) imines of the present invention, IA, IB, IC and existing antiviral agent diazosulfide, tiadinil, be abbreviated as TDL, isotianil, it is English general by name: isotianil, 4-methyl isophthalic acid, 2, 3-thiadiazoles-5-formic acid, 4-methyl isophthalic acid, 2, 3-thiadiazoles-5-sodium formiate, 4-methyl isophthalic acid, 2, 3-thiadiazoles-5-ethyl formate, 3, 4-bis-chloroisothiazoles-5-formic acid, 3, 4-bis-chloroisothiazoles-5-sodium formiate, 3, 4-bis-chloroisothiazoles-5-ethyl formate, DL-beta-aminobutyric acid, virazole, antofine, Ningnanmycin, tisocromide, first thiophene lures amine or Whitfield's ointment, cytosintetidemycin, dichloro-isonicotinic acid, allyl isothiazole, well ridge azanol, in jingganmycin, any 1 or 2 compound combinations are used for preventing and treating agricultural and forestry and gardening plant virus disease, be selected from tobacco mosaic virus disease for the disease of preventing and treating agricultural and forestry and gardening plant virus disease, various melon virus diseases, various solanaceous vegetables virus diseases, beans virus disease, Cruciferae virus disease, grain and oil crop virus disease, any in cotton virus disease and various fruit tree virus disease, wherein endanger serious being selected from: tobacco virus, peppery pimento virus disease, tomato virus disease, Chinese cabbage virus disease, Virus Diseases of Rice comprises rice dwarf virus disease, yellow dwart, stripe virus disease, fern leaf of tomato viral disease, pepper mosaic virus disease viral disease and tobacco veinal necrosis virus disease, maize dwarf mosaic, cauliflower mosaic virus, oranges and tangerines virus disease, cymbidium mosaic virus, any in cybidium ring spot virus, these compositions are selected from paddy for the plant that prevents and treats agricultural and forestry and gardening plant virus disease, wheat, barley, oat, corn, Chinese sorghum, sweet potato, potato, cassava, soybean, pea-pods, broad bean, pea, mung bean, red bean, cotton, silkworm and mulberry, peanut, rape, sesame, Sunflower Receptacle, beet, sugarcane, coffee, cocoa, ginseng, the bulb of fritillary, rubber, coconut, oil palm, sisal hemp, tobacco, tomato, capsicum, radish, cucumber, Chinese cabbage, celery, hot pickled mustard tube, beet, rape, green onion, garlic, watermelon, muskmelon, hami melon, pawpaw, really, tea, wild vegetable, bamboo shoots, hops, potato, paddy rice, pepper, apple, banana, citrus, peach, papaya, orchid, potted landscape agricultural, gardening, economical, forestry plant, the use of these compositions improves the immunizing power of crop self, in producing the control of insect especially infection insect, has induced plant to produce the defence capability to viral diseases of plants, also can produce the direct prevention effect of virus disease, therefore, these compositions can be for preparation and the purposes of Antiphytoviral medicament and inducing plant Antiphytoviral medicament, anthranilic diamides derivative I, IA, IB, the total quality percentage composition of IC in composition containing N-cyano group sulfone (sulphur) imines of the present invention is 1%-90%, and the ratio of anthranilic diamides derivative I, IA, IB, IC and aforementioned anti-plant virus agent containing N-cyano group sulfone (sulphur) imines of the present invention is mass percent 1%: 99% to 99%: 1%, the formulation of composition processing is selected from sustained release dosage, pulvis, micro-capsule suspension, dispersible body preparation, dispersible solid preparation, seed treatment emulsion, aqueous emulsion, granule, microemulsion, finish, with the seed of coated pesticidal, suspended emulsion agent, soluble thick agent, poison grain, aerosol, block poison bait, sustained-release block, dense poison bait, capsule suspension, dispersible dense dose, missible oil, electrostatic spray agent, water-in-oil emulsion, seed treatment agent, oil-in-water emulsion, smoke candle, granula subtilis, smoke candle, smoke cartridge, smog rod, smog sheet, smoke substance, smog ball, granular poison bait, foaming agent, ointment, thermal fog, solid-liquid mixes dress agent, liquid/liquid mixes dress agent, cold mist agent, Gu Gu/mix filling agent, medicine paint, seed treatment liquor, microgranules, oil suspending agent, finish, oil-dispersing property pulvis, paste, sheet poison bait, dense jelly, sprinkle and water agent, stylus, seed coat agent, poison bait, basting agent, fritter poison bait, suspension agent, suspension emulsion, water-soluble granule, soluble thick agent, film forming finish, tablet, follow the trail of pulvis, ultra low volume liquids, any one in steam releasing agent, between these compositions, all show and be added or synergism, in keeping insecticidal activity, its antiviral activity is all greater than the effect that any one compound uses separately, find no the composition of antagonistic action, the drug effect lasting period of composition is long.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110396079A (en) * 2019-06-12 2019-11-01 东南大学 A kind of preparation method and applications of Rynaxypyr intermediate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1829707A (en) * 2003-01-28 2006-09-06 杜邦公司 Cyano anthranilamide insecticides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1829707A (en) * 2003-01-28 2006-09-06 杜邦公司 Cyano anthranilamide insecticides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHRISTIAN GNAMM, ET AL: "Novel diamide insecticides: Sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110396079A (en) * 2019-06-12 2019-11-01 东南大学 A kind of preparation method and applications of Rynaxypyr intermediate

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