CN104027498A - Formula against infertility - Google Patents

Abstract

The invention provides a formula against infertility. The formula has the functions of nourishing blood and benefiting yin as well as reinforcing kidney and generating sperm. The formula is mainly used for treating amenorrhea caused by blood insufficiency and kidney deficiency, i.e., the formula has excellent effects for treating the amenorrhea with symptoms such as sexual hypoactivity, genital atrophy, vaginal secretion reduction, shedding of pubes, mastatrophy and mastatrophy. The traditional Chinese medicine composition is prepared from the following more than ten raw medicine materials which are matched by weight: angelica, radix paeoniae alba, rhizoma ligustici wallichii, prepared rhizome of rehmannia, rubus idaeus, dodder, fructus schisandrae, semen plantaginis, twotooth achyranthes root, medlar, curculigo and epimedium. The traditional Chinese medicine composition is mainly used for treating the amenorrhea caused by the blood insufficiency and the kidney deficiency of a female, i.e., the composition has the excellent effects for treating the amenorrhea with symptoms such as sexual hypoactivity, genital atrophy, vaginal secretion reduction, shedding of pubes, mastatrophy and mastatrophy. The formula provided by the invention is prepared by utilizing the purely natural traditional Chinese medicine ingredients, so that a side effect to a human body is avoided.

Description

One is educated son side

Technical field

The present invention relates to a kind of medical science medicine section field, one is educated son side.

Technical background

As far back as nineteen ninety-five, World Health Organization (WHO) just predicts: in 21 century, infertility will become the third-largest disease that is only second to tumor and cardiovascular and cerebrovascular disease.In recent years, along with the increasing the weight of of environmental pollution, the opening of members of society attitude towards sex and the transformation of people life style, infertility sickness rate is ascendant trend year by year, and this prophesy has become indubitable fact already.

Infertility refers to that wife's side reproductive function is normal with child-bearing period woman after marriage or after last gestation, matrimonial cohabitation is more than 2 years, contraception and not becoming pregnant for the disease of main manifestations.It is infertile that 2 years after marriage persons that never do not become pregnant are called originality; Once had fertility or miscarriage, continuous 2 years above infertile persons, are called secondary infertility again.There is the abnormal or physiological defect in serious anatomy congenital or posteriority no matter the infertile Mr. and Mrs of the meaning both sides of absoluteness are which side, no matter adopt which kind of method treatment all cannot rescue successfully, and cause infertile a kind of clinical sign, as congenital absence of uterus.Relative property is infertile to be meant and causes certain cause of disease of the difficulty of becoming pregnant to reduce fertility, causes patient temporarily can not become pregnant, but still can become pregnant by treatment, as uterine hypoplasia etc.The incidence rate of infertility accounts for 8%～17% of Women in menopause, average out to 10% left and right.The trend that increases progressively of infertility sickness rate may be relevant to late marriage and childbirth, artificial abortion, sexually transmitted disease (STD) etc.Common are that ovary is infertile, vulvovaginal is infertile, cervix uteri is infertile, uterus property is infertile, tubal infertility, chromosomal abnormality are infertile, infertility.

Female acyesis factor.

(1) vulvovaginal factor forms adhesion cicatricial stricture after comprising pudendum, vagina abnormal development, vaginal injury, affects sperm and enters cervix uteri, impact insemination, colpitis etc.

(2) cervix uteri factor cervix uteri is the approach that sperm enters uterine cavity, and can cervix uteri mucus amount and character all can affect sperm enter uterine cavity.

Cervical canal dysplasia, elongated, affect sperm and pass through; Glandular secretion deficiency of cervical canal mucosa dysplasia, Cervicitis and vegetation, as cervical polyp, cervical myoma etc. block cervical canal impact insemination.

(3) fallopian tube factor fallopian tube has and transports sperm, picks up ovum and germ cell is transported to the function of uterine cavity.Fallopian tube pathological changes is the common factors of infertility, and any factor that affects Tubal Function of Sterility all affects insemination.Oviduct Development is complete, salpingitis tubal, fallopian tube around pathological changes etc. these be all to affect infertile factor.

(4) abnormal, uterus tumor of uterine factors uterus congenital malformation, inner membrance etc. these can cause infertile.

(5) abnormal, the endometriosis of the Ovarian factor development of ovary, liteinifzed unruptured follicle syndrome, ovarian tumor, inadequate luteal function impact are become pregnant.

(6) ovulation failure causes ovarian dysfunction and causes anovular factor and all can cause infertile.

(7) psychological factor inferiority complex, irritability, psychentonia, social minimizing, lacks interest to life, and impatience is worried too much, the sense of loss.

Irregular menstruation:

Change in menstrual cycle: menstruation is done sth. in advance or postponed; Too much through measuring, very few; Menostaxis; There are amenorrhea, dysmenorrhea, irregular vagina bleeding.

Breast and diacrisis:

Non-lactation period breast has milk to overflow voluntarily or after extruding, many promptings have that hypothalamic function is complete, pituitary tumor, the disease such as prolactinoma or Pituitary hypothyroidism, chronic renal failure, also can cause by taking the depressor such as contraceptive and reserpine, galactorrhea often merges amenorrhea and causes infertile.

Vagina inflammatory diseases:

Cause that vaginal secretions increases, adnexal tumor, thicken and tenderness.

Symptoms around menstruation:

Periodically there is breast distention during menstruation before and after minority women's menstruation, have a headache, have loose bowels, edema, heating, erosion of the oral mucosa, facial acne, rubella wheal, depression or the series of symptoms such as irritated, often because endocrine disturbance's luteal phase defect causes, often can cause infertile; Endometrium development is slow, uterine hypoplasia and deformity; Severe malnutrition, build and Body Mass Index are that body weight (kg)/height (m2) is abnormal etc.

Every hormone and infertile checkout

Estrogen test progesterone test: negative patient can row estrogen test, to determine that the negative reason of progesterone test is whether as estrogen level is low.

Progesterone test: judge that ovary has or not the feasible progesterone test of estrogen secretion.

FSH, LH, PRL measure: suitably time, measure the various hormonal readinesses in blood, can obtain the functional status of ovary and affect the more information in the aspects such as link, FSH, LH in detection serum, PRL, E2 can identification of ovarian or hypophysis ovulation failure in amenorrhea.As determined, whether ovary has lost the estrogenic ability of secretion, or promoting sexual gland hormone and ovary is not secreted steroid hormone for want of.Use measured by radioimmunoassay promoting sexual gland hormone, come identification of ovarian or hypophysis ovulation failure and amenorrhea by serum FSH, LH, PRL, E2 value.

GnRH pituitary stimulating test: the excitement of GnRH hypophysis is LHRH test, and it can distinguish hypothalamus or pituitary amenorrhea, prompting GnRH therapeutic response.

Promoting sexual gland hormone test: part sieve rice phenol negative, progesterone test or the estrogen test positive.The 5th day intramuscular injection HMG70～150U/d after withdrawal vaginal hemorrhage, Monitoring Ovulation in continuous use process, when follicle maturity, then intramuscular injection HCG5000～10000U/d, there is ovulation for the promoting sexual gland hormone test positive.

Part sieve rice phenol test method: I degree amenorrhea person is the 5th day oral part of sieve rice phenol of vaginal hemorrhage after drug withdrawal, 50～100mg/d, totally 5 days.The amenorrhea of the slight hypothalamus type of positive prompting.

ACTH stimulation test: ACTH20mg, intramuscular injection, surveys respectively the forward and backward twenty-four-hour urine 17-KS of medication and 17OHS excretion.PCOS person reacts normally, and the abnormal person's 17-KS of adrenal cortex function and 17OHS all obviously increase.

Thyroliberin (TRH) irritant test: TRH is a kind of tripeptides, energy Stimulation of Pituitary Gland cell, secretion thyrotropin and prolactin antagonist patient first urinate, the 20min that lies up, is dissolved in normal saline rapid intravenous injection 5,10 by 100 μ gTRH, 15,30 measure with 60min blood drawing, and prolactin antagonist in 15 minutes (PRL) is as higher 5～10 times than base value, and this type of patient has the tendency of hyperprolactinemia.General PRL<120 μ g/L is normal reaction, and 120～150 μ g/L are suspicious, and >150 μ g/L is overreaction.

Dexamethasone suppression test: be applicable to the womanlike patient of amenorrhea.Dexamethasone 0.5mg, every 6 hours 1 time, totally 2 days or 7 days, relatively urine 17-ketosteroid before medication, 17OHS, testosterone, the variations such as blood dehydroepiandrosterone.If Hypophysis-adrenal cortex axis function is normal, after medication due to negative feedback, suppress ACTH, urine 17-ketosteroid and 17OHS value reduce.But Cushing syndrome, adrenal cortical tumor patient do not reduce.

Hydrotubation: there is larger blindness, be difficult to fallopian tube morphological function to make comparatively correct judgement, but because method simply can be used as screening test.Review time should be arranged in menstruation clean latter 3～7 days, without carrying out in the situation of gynecological inflammation and sexual life.

B ultrasonic monitors lower hydrotubation: can under ultrasonic surveillance, observe the acoustic image that the fallopian tube of flowing through after liquid (also can select special contrast medium for ultrasonic diagnosis) injects occurs and change.Without the blindness of traditional hydrotubation, reach 81.8% with laparoscopy coincidence rate; And harmless to uterus, Fallopian tube mucosa, side effect is light.Operational approach is similar to hydrotubation, adopts the omnidistance supervision of B ultrasonic before and after filling liquid and in process.Result evaluation: unobstructed: see uterine cavity interior formation no echo area and move the visible opaque dark area of fluid of rear arched roof to bilateral fallopian tube direction.Logical and not smooth: while injecting liquid, to have resistance, repeatedly press a little to inject and see the liquid fallopian tube of flowing through, the visible opaque dark area of fluid of rear arched roof.Block: it is large to inject resistance, and see that uterine cavity dark space expands, patient tells stomachache, and rear arched roof has no opaque dark area of fluid.

Hysterosalpingography: cavity of uterus is also had than more comprehensive understanding, can judge the pathological changes of 5mm size in uterine cavity, easy and simple to handle.Contrast agent can adopt 40% iodized oil or 76% cardiografin; Occur iodine allergy possibility, preoperative need do skin test.Patient lies on the back in x-ray examining table, intrauterine injection cardiografin contrast agent.First take first sheet to understand uterine cavity and fallopian tube, continue to inject contrast agent and take the photograph second sheet simultaneously, observe and have contrast-agent-free to enter pelvic cavity and disperse situation in pelvic cavity; After 24 hours, take the photograph second sheet if adopt iodized oil.Shown in sheet, analyze tubal patency situation, rate of accuracy reached 80% according to taking the photograph.

The logical liquid art of fallopian tube intubate under hysteroscope: interstitial portion is often because the illusion of blocking appears in spasm, residual, the slight adhesion of tissue debris and cicatrix in the time that logical liquid is tested, under direct-view of hysteroscope from fallopian tube to uterine cavity opening part intubate logical liquid or radiography can to interstitial portion directly dredging and lavation effect, be diagnosis and treat the reliable method that fallopian tube interstitial portion blocks.

Laparoscopy: can look at pelvic organs straight, can judge comprehensively, accurately, in time the nature and extent of each organ lesion.Can dynamically observe tubal patency degree by logical liquid test under mirror, play a part dredging oviduct chamber simultaneously, be one of best means of female acyesis inspection, the diagnosis that ovulatory dysfunction is infertile.

Summary of the invention

The vacancy that takes prior art for part, with not enough, the invention provides one and educates son side, function: the tonifying YIN that nourishes blood, kidney-tonifying sperm-generating; Cure mainly: blood deficiency amenorrhea that deficiency of the kidney causes, card is shown in hyposexuality, genital atrophy, vaginal secretions reduces, and pubes come off, mastatrophy, neurolysis.

The present invention's medicine pharmacology and property of medicine used is as follows:

Radix Angelicae Sinensis:

Meridian distribution of property and flavor: sweet, pungent, warm; Return liver, the heart, spleen channel;

Function cures mainly: enrich blood invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores; Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow; For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

The Radix Paeoniae Alba:

Meridian distribution of property and flavor: bitter, acid, be slightly cold; Return liver, spleen channel;

Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating; Dizzy, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat are used for having a headache.

Rhizoma Chuanxiong:

Meridian distribution of property and flavor: pungent, warm; Return liver, gallbladder, pericardium channel;

Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping; For menoxenia, amenorrhea dysmenorrhea, mass in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Radix Rehmanniae Preparata:

Meridian distribution of property and flavor: sweet, tepor; Return liver, kidney channel;

Function cures mainly: nourishing YIN and supplementing blood, beneficial essence are filled out marrow; For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, interior-heat quench one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.

Fructus Rubi:

Meridian distribution of property and flavor: sweet, sour, warm; Return kidney, urinary bladder channel;

Function cures mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination; For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea.

Semen Cuscutae:

Meridian distribution of property and flavor: sweet, warm; Return liver,kidney,spleen warp;

Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal; Suffer from a deficiency of the kidney for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen rush down, externally treating leucoderma.

Fructus Schisandrae Chinensis:

Meridian distribution of property and flavor: sour, sweet, warm; Return lung, the heart, kidney channel;

Function cures mainly: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming; , lose heart deficient pulse thirsty for chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound, interior-heat are quenched one's thirst, palpitation and insomnia.

Semen Plantaginis:

Meridian distribution of property and flavor: sweet, be slightly cold; Return liver, kidney, lung, small intestine meridian;

Function cures mainly: clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminate the phlegm; For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.

Radix Achyranthis Bidentatae:

Meridian distribution of property and flavor: bitter, acid, flat; Return liver, kidney channel;

Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards; For soreness of waist and knee joint, muscles and bones is unable, amenorrhea { note of the ancient Chinese } abdominal mass, dizziness due to hyperactivity of liver-YANG.

Fructus Lycii:

Meridian distribution of property and flavor: sweet, flat; Return liver, kidney channel;

Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight; For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat quench one's thirst, blood deficiency and yellow complexion, blurred vision be not clear.

Rhizoma Curculiginis:

Meridian distribution of property and flavor: pungent, hot, poisonous; Return kidney,liver,spleen warp;

Function cures mainly: kidney-replenishing, bone and muscle strengthening, dispelling cold and dampness; , waist knee joint cold numbness soft for sexual impotence cold sperm, muscles and bones flaccidity, yang deficiency cold diarrhea.

Herba Epimedii:

Meridian distribution of property and flavor: pungent, sweet, warm; Return liver, kidney channel;

Function cures mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; , rheumatic arthralgia soft for impotence and seminal emission, muscles and bones flaccidity, numbness contracture, climacteric hypertension.

The technical scheme that the present invention solves is: one is educated son side, is to be formed by following weight parts raw material of Chinese medicine compatibility:

Radix Angelicae Sinensis 9-12 part, Radix Paeoniae Alba 6-15 part, Rhizoma Chuanxiong 3-9 part, Radix Rehmanniae Preparata 9-15 part,

Fructus Rubi 6-12 part, Semen Cuscutae 6-12 part, Fructus Schisandrae Chinensis 6-12 part, Semen Plantaginis 9-15 part,

12 parts of Radix Achyranthis Bidentatae 6-12 parts, Fructus Lycii 9-15 part, Rhizoma Curculiginis 3-9 part, Herba Epimedii;

Preparation method: be decocted in water for oral dose, 1 dose of day, sub-service sooner or later; Former side's plus-minus: if QI and blood extremely feeble can add Radix Ginseng, the Radix Astragali with QI invigorating, benefit doubly; Though we are treatment married woman infertility efficacious prescriptions, also can be used for treating the few smart each azoospermia of man, there are the function of ovulation rate and the effect of increase seminal fluid; Man can change Fructus Cnidii into this side, Semen Plantaginis.

One of the present invention is educated son side, is to be formed by following weight parts raw material of Chinese medicine compatibility:

9 parts of Radix Angelicae Sinensis, 9 parts of the Radix Paeoniae Albas, 3 parts of Rhizoma Chuanxiongs, 12 parts, Radix Rehmanniae Preparata,

9 parts of Fructus Rubies, 9 parts of Semen Cuscutae, 9 parts of Fructus Schisandrae Chinensis, 9 parts of Semen Plantaginiss,

12 parts of Radix Achyranthis Bidentataes, 15 parts of Fructus Lycii, 9 parts of Rhizoma Curculiginises, 12 parts of Herba Epimedii.

The invention has the beneficial effects as follows: function: the tonifying YIN that nourishes blood, kidney-tonifying sperm-generating; Cure mainly: blood deficiency amenorrhea that deficiency of the kidney causes, card is shown in hyposexuality, genital atrophy, vaginal secretions reduces, and pubes come off, mastatrophy, neurolysis effect is splendid.

Tool of the present invention has the following advantages: it is fast to the splendid curative effect of female sterility effect originally to educate son side, and natural Chinese medicine composition has no side effect to health.

Detailed description of the invention

Embodiment: female infertility, blood deficiency amenorrhea that deficiency of the kidney causes, card is shown in hyposexuality, genital atrophy, vaginal secretions reduces, and pubes come off, mastatrophy, neurolysis, we's card is shown in: feelings will is not relaxed, depressed irritability, and delay of menstrual cycle amount is few, more very, stringy and thready pulse is puckery for row and not smooth or premenstrual few abdomen mammary swelling pain.Often need a longer adjustment and recovery process.We's clinical treatment 100 examples, cure 90 examples, effective 10 examples, former side's plus-minus: if QI and blood extremely feeble can add Radix Ginseng, the Radix Astragali with QI invigorating, benefit doubly.Though we are treatment married woman infertility efficacious prescriptions, also can be used for treating the few smart each azoospermia of man.Clinical observation, has the function of ovulation rate and the effect of increase seminal fluid.Man can change Fructus Cnidii into this side, Semen Plantaginis.Note self nursing one's health of daily schedule, not only beneficial to aristogenesis, and the healthy of oneself is also beneficial to.

Above-described embodiment is preferably embodiment of the present invention, but embodiments of the present invention are not restricted to the described embodiments, and the present invention not part of detailed description is known technology.

Claims (2)

1. educate son side for one kind, it is characterized in that: formed by following weight parts raw material of Chinese medicine compatibility:

Radix Angelicae Sinensis 9-12 part, Radix Paeoniae Alba 6-15 part, Rhizoma Chuanxiong 3-9 part, Radix Rehmanniae Preparata 9-15 part,

Fructus Rubi 6-12 part, Semen Cuscutae 6-12 part, Fructus Schisandrae Chinensis 6-12 part, Semen Plantaginis 9-15 part,

12 parts of Radix Achyranthis Bidentatae 6-12 parts, Fructus Lycii 9-15 part, Rhizoma Curculiginis 3-9 part, Herba Epimedii;

Preparation method: be decocted in water for oral dose, 1 dose of day, sub-service sooner or later; Former side's plus-minus: if QI and blood extremely feeble can add Radix Ginseng, the Radix Astragali with QI invigorating, benefit doubly; Though we are treatment married woman infertility efficacious prescriptions, also can be used for treating the few smart each azoospermia of man, there are the function of ovulation rate and the effect of increase seminal fluid; Man can change Fructus Cnidii into this side, Semen Plantaginis.

2. one according to claim 1 is educated son side, it is characterized in that: formed by following weight parts raw material of Chinese medicine compatibility:

9 parts of Radix Angelicae Sinensis, 9 parts of the Radix Paeoniae Albas, 3 parts of Rhizoma Chuanxiongs, 12 parts, Radix Rehmanniae Preparata,

9 parts of Fructus Rubies, 9 parts of Semen Cuscutae, 9 parts of Fructus Schisandrae Chinensis, 9 parts of Semen Plantaginiss,

12 parts of Radix Achyranthis Bidentataes, 15 parts of Fructus Lycii, 9 parts of Rhizoma Curculiginises, 12 parts of Herba Epimedii.