CN104014810B - A kind of method utilizing octreotide acetate to prepare the spherical cobalt-platinum alloy of chain for template - Google Patents
A kind of method utilizing octreotide acetate to prepare the spherical cobalt-platinum alloy of chain for template Download PDFInfo
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- CN104014810B CN104014810B CN201410234005.0A CN201410234005A CN104014810B CN 104014810 B CN104014810 B CN 104014810B CN 201410234005 A CN201410234005 A CN 201410234005A CN 104014810 B CN104014810 B CN 104014810B
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- octreotide acetate
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Abstract
A kind of method utilizing octreotide acetate to prepare the spherical cobalt-platinum alloy of chain for template, it mainly dissolves octreotide acetate with the hydrochloric acid solution of pH 2～3, octreotide acetate is adjusted to the acid solution of 0.4～0.8mM, mol ratio by octreotide acetate Yu cobalt chloride, the mol ratio of octreotide acetate and platinum tetrachloride is all the ratio of 1:5, cobalt chloride and the platinum tetrachloride solution of same volume it is simultaneously introduced in octreotide acetate solution, and put it in water-bath constant temperature oscillator, 20～26h are hatched at 100～200rpm, 13～25 DEG C；Then the disposable borane reducing agent sodium hydride that adds in the above-mentioned solution hatched, control octreotide acetate is respectively 1:30 or 1:20 or 1:17.5 with the mol ratio of sodium borohydride so that it is become aterrimus from faint yellow, i.e. obtains the spherical cobalt-platinum alloy of chain.The present invention has that preparation technology is simple, mild condition, cheap and easy to get, reacts easily controllable, and productivity is high, be easily achieved the advantages such as large-scale production.
Description
Technical field
The invention belongs to Nanoalloy field of material technology, particularly to the preparation method of a kind of nano material.
Background technology
It is known that under many circumstances, the characteristic of alloying can strengthen at coordinating effect.Cobalt platinum is closed
Gold due to its powerful catalytic performance and magnetic property etc. so that it is be widely used in catalysis, sensor, electronics and
Magnetic device, therefore prepares pattern rule, and the cobalt-platinum alloy of good dispersion causes the great interest of people.
The preparation method of cobalt-platinum alloy is a lot, mainly has molecular beam epitaxy, magnetron sputtering method and chemical synthesis
Method prepares cobalt-platinum alloy, such as colloid synthetic method, electrochemical deposition method, polyalcohol co-reducing process etc..Above-mentioned
Some technology of preparation method requires height, apparatus expensive, some complex process, and environmental pollution is relatively big, some
Need longer reaction time, higher temperature and pressure and special device anyway, cause production cost
Higher, it is difficult to accomplish scale production.
Summary of the invention
It is an object of the invention to provide the profit that a kind of preparation cost is cheap, pollution-free, technique is simple, controlled
It is the method that template prepares the spherical cobalt-platinum alloy of chain with octreotide acetate.The present invention mainly uses acetic acid Austria bent
Peptide is template, utilizes the perfect and strict molecular recognition function that biomolecule is had, passes through physical chemistry
Method requires the avtive spot located growth nano metal particles on its surface, biomolecule simultaneously according to design
The synthesis of nano particle can accurately be controlled by the architectural feature of self and space confinement effect thereof, thus
Obtain the spherical cobalt-platinum alloy of intended chain.
Technical scheme is as follows:
(1) take octreotide acetate, be that 2～3 hydrochloric acid solutions dissolve 0.4～0.8mg acetic acid with every ml of ph
Octreotide, is configured to the 0.4～0.8mM acidity octreotide acetate solution that pH value is 2～3；
(2) in the octreotide acetate solution that step (1) has been reconciled, it is simultaneously introduced the cobalt chloride of same volume
With platinum tetrachloride solution, and the cumulative volume of the cobalt chloride that adds and platinum tetrachloride solution is molten with octreotide acetate
The volume of liquid is identical, puts it in water-bath constant temperature oscillator, incubates at 100～200rpm., 13～25 DEG C
Educate 20～26h；
(3) the disposable borane reducing agent sodium hydride that adds, control acetic acid in the solution that step (2) is hatched
Octreotide is respectively 1:30 or 1:20 or 1:17.5 with the mol ratio of sodium borohydride so that it is rapidly by yellowish discoloration
For aterrimus, i.e. can get the spherical cobalt-platinum alloy of chain of monodispersity 40 55nm good, a diameter of.
The present invention compared with prior art has the advantage that
1, the present invention uses octreotide acetate to be template, and its molecular formula is
H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-OL (Cys2-Cys7), molecular structure is simple, it is easy to
Analyze and control, and due to electrostatic interaction, intended particle is easily absorbing the surface of octreotide acetate and lives
Property site, and then generate pattern rule cobalt-platinum alloy.
2, obtained chain spherical cobalt-platinum alloy good dispersion, pattern typical case, form rule, structure-controllable.
3, preparation technology is simple, cheap and easy to get, and reaction condition is gentle, and its process is easily controllable, equipment
Ask low, it is easy to large-scale production.
4, the reducing agent, reaction medium and the reactant price that are used are low, pollution-free.
Accompanying drawing explanation
Fig. 1 is the TEM figure of the cobalt-platinum alloy particle that the embodiment of the present invention 1 obtains.
Fig. 2 is the TEM figure of the cobalt-platinum alloy particle that the embodiment of the present invention 2 obtains.
Fig. 3 is the EDS figure of the cobalt-platinum alloy particle that the embodiment of the present invention 2 obtains.
Fig. 4 is the TEM figure of the cobalt-platinum alloy particle that the embodiment of the present invention 3 obtains.
Detailed description of the invention
Embodiment 1
Take the octreotide acetate (production of gill biochemistry Shanghai Co., Ltd) of 0.4mg, be dissolved in the salt of 1mL pH 2
In acid solution, it is configured to the 0.4mM octreotide acetate solution that pH value is 2；Take above-mentioned octreotide acetate molten
Liquid 200 μ L, is simultaneously introduced platinum tetrachloride solution (the auspicious section in the Shaanxi limited public affairs of new material share of 100 μ L 4mM
Department) and the cobalt chloride solution (West Asia, Shanghai reagent Co., Ltd) of 100 μ L 4mM；Prepare above-mentioned
Solution put in water-bath constant temperature oscillator, in 130rpm., after hatching 26h at 13 DEG C, disposably add
80 μ L 30mM borane reducing agent sodium hydrides (production of Beijing Zhong Sheng Hua Teng Science and Technology Ltd.) reduce so that it is
Become aterrimus from faint yellow, i.e. obtain the spherical cobalt-platinum alloy of chain.
Application transmission electron microscope cobalt-platinum alloy spherical to chain carries out morphology characterization, as it is shown in figure 1, hammer
A diameter of 45-55nm of shape nanometer cobalt platinum alloy particle, pattern rule, it is evenly distributed.
Embodiment 2
Take the octreotide acetate (production of gill biochemistry Shanghai Co., Ltd) of 0.6mg, be dissolved in 1mL pH's 2.5
In hydrochloric acid solution, it is configured to the 0.6mM octreotide acetate solution that pH value is 2.5；Take above-mentioned acetic acid Austria bent
Peptide liquid 200 μ L, is simultaneously introduced the platinum tetrachloride solution (production of Tianjin chemical reagent factory) of 100 μ L 6mM
Cobalt chloride solution (West Asia, Shanghai reagent Co., Ltd) with 100 μ L 6mM；Prepare above-mentioned
Solution is put in water-bath constant temperature oscillator, in 160rpm., after hatching 24h at 20 DEG C, disposably adds 100
μ L 24mM borane reducing agent sodium hydride (production of Beijing Zhong Sheng Hua Teng Science and Technology Ltd.) reduces so that it is from
Faint yellow become aterrimus, i.e. obtain the spherical cobalt-platinum alloy of chain.
Application transmission electron microscope cobalt-platinum alloy spherical to chain carries out morphology characterization, as in figure 2 it is shown, hammer
A diameter of 40-50nm of shape nanometer cobalt platinum alloy particle, pattern rule, it is evenly distributed.
Application energy disperse spectroscopy cobalt-platinum alloy spherical to chain characterize, as it is shown on figure 3, power spectrum occurs Co, Pt,
The peak that C, O, Cl element is corresponding, illustrates that the metallic element being combined in octreotide acetate surface is cobalt and platinum, O
Element is the element in albumen, and C element is the element in copper mesh, also can there are some C units in addition in albumen
Element, illustrates that octreotide acetate is well combined with cobalt platinum particle, and purity is the highest, it is the most thorough that Cl element carrys out autoreduction
The cobalt chloride at the end and platinum chloride.
Embodiment 3
Take the octreotide acetate (production of gill biochemistry Shanghai Co., Ltd) of 0.8mg, be dissolved in the salt of 1mL pH 3
In acid solution, it is configured to the 0.8mM octreotide acetate solution that pH value is 3；Take above-mentioned octreotide acetate liquid
200 μ L, are simultaneously introduced the platinum tetrachloride solution (production of Tianjin chemical reagent factory) and 100 of 100 μ L 8mM
The cobalt chloride solution (West Asia, Shanghai reagent Co., Ltd) of μ L 8mM；The above-mentioned solution prepared is put
Enter in water-bath constant temperature oscillator, in 200rpm., after hatching 20h at 25 DEG C, disposable addition 80 μ L 35
MM borane reducing agent sodium hydride (production of Beijing Zhong Sheng Hua Teng Science and Technology Ltd.) reduces so that it is from faint yellow
Become aterrimus, i.e. obtain the spherical cobalt-platinum alloy of chain.
Application transmission electron microscope cobalt-platinum alloy spherical to chain carries out morphology characterization, as shown in Figure 4, hammer
A diameter of about 55nm of shape nanometer cobalt platinum alloy particle, pattern rule, it is evenly distributed.
Claims (1)
1. utilize the method that octreotide acetate prepares the spherical cobalt-platinum alloy of chain for template, its
It is characterised by:
(1) take octreotide acetate, with every ml of ph be 2～3 hydrochloric acid solutions dissolve 0.4～
0.8mg octreotide acetate, is configured to the 0.4～0.8mM acidity acetic acid that pH value is 2～3
Octreotide solution；
(2) mol ratio of octreotide acetate and cobalt chloride, octreotide acetate and platinum tetrachloride are pressed
Mol ratio be all the ratio of 1:5, be simultaneously introduced identical in the solution that step (1) prepares
The cobalt chloride of volume and platinum tetrachloride solution, and ensure the cumulative volume of cobalt chloride and platinum tetrachloride
Identical with the volume of octreotide acetate solution, put it in water-bath constant temperature oscillator, in 100～
200rpm., hatches 20～26h at 13～25 DEG C；
(3) it is 1:30 or 1:20 by the mol ratio of octreotide acetate Yu borane reducing agent sodium hydride
Or the ratio of 1:17.5 disposably adds borane reducing agent in the solution that step (2) is hatched
Sodium hydride so that it is become aterrimus from faint yellow rapidly, i.e. can get a diameter of 40 55nm
The spherical cobalt-platinum alloy of chain.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104551002B (en) * | 2014-12-26 | 2017-02-22 | 燕山大学 | Method for preparing quincuncial platinum nanoparticles by taking lanreotide acetate as template |
| CN105312591B (en) * | 2015-11-13 | 2017-04-26 | 燕山大学 | Method for preparing annular platinum nanoparticles with lanreotide acetate serving as template |
| CN105458287B (en) * | 2015-11-30 | 2017-05-31 | 燕山大学 | The method that caged golden nanometer particle is prepared using lanreotide acetate template |
| CN105642914B (en) * | 2016-03-29 | 2017-08-29 | 燕山大学 | A kind of method that the spherical Pd nano particle of chain is synthesized by templating self-assembly of bacitracin |
| CN105728745B (en) * | 2016-04-29 | 2017-10-20 | 燕山大学 | A kind of method that the spherical Platinum Nanoparticles of chain are synthesized by templating self-assembly of bacitracin |
| CN106735289B (en) * | 2016-11-30 | 2018-09-04 | 燕山大学 | A method of preparing cubic silver nanoparticle box by template of octreotide acetate |
| CN108339990A (en) * | 2018-03-30 | 2018-07-31 | 燕山大学 | A kind of preparation method of the silver-colored palladium core-shell nanospheres with catalytic activity |
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| CN102658371A (en) * | 2012-03-02 | 2012-09-12 | 燕山大学 | Preparation method of ultrafine platinum nano-wire |
| CN102784924A (en) * | 2012-07-16 | 2012-11-21 | 燕山大学 | Water phase preparation method for chain platinum nanosphere by taking octreotide acetate as template |
| CN102784925A (en) * | 2012-07-16 | 2012-11-21 | 燕山大学 | Method for preparing gold nano particle chains in aqueous phase by taking octreotide acetate as template |
| CN103055893A (en) * | 2012-12-25 | 2013-04-24 | 北京化工大学 | Supported cobalt-platinum superlattice alloy nano particle composite catalyst and preparation method thereof |
| CN103203461A (en) * | 2013-03-21 | 2013-07-17 | 燕山大学 | Method for preparing hammer-shaped palladium nanoparticle by utilizing octreotide acetate as template |
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| ATE544566T1 (en) * | 2007-03-27 | 2012-02-15 | Ludmilla Morozova-Roche | METHOD FOR PRODUCING THIN METAL NANOWIRES BY BIOTEMPLATING |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102658371A (en) * | 2012-03-02 | 2012-09-12 | 燕山大学 | Preparation method of ultrafine platinum nano-wire |
| CN102784924A (en) * | 2012-07-16 | 2012-11-21 | 燕山大学 | Water phase preparation method for chain platinum nanosphere by taking octreotide acetate as template |
| CN102784925A (en) * | 2012-07-16 | 2012-11-21 | 燕山大学 | Method for preparing gold nano particle chains in aqueous phase by taking octreotide acetate as template |
| CN103055893A (en) * | 2012-12-25 | 2013-04-24 | 北京化工大学 | Supported cobalt-platinum superlattice alloy nano particle composite catalyst and preparation method thereof |
| CN103203461A (en) * | 2013-03-21 | 2013-07-17 | 燕山大学 | Method for preparing hammer-shaped palladium nanoparticle by utilizing octreotide acetate as template |
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