CN104001179A - Expansion carrier for bearing effective components and application thereof - Google Patents
Expansion carrier for bearing effective components and application thereof Download PDFInfo
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- CN104001179A CN104001179A CN201410271348.4A CN201410271348A CN104001179A CN 104001179 A CN104001179 A CN 104001179A CN 201410271348 A CN201410271348 A CN 201410271348A CN 104001179 A CN104001179 A CN 104001179A
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- expansion carrier
- expansion
- carrier
- active component
- carrying active
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Absorbent Articles And Supports Therefor (AREA)
Abstract
The invention relates to an expansion carrier for bearing effective components and application thereof. The expansion carrier can be expanded according to a reset value in water solution, an expansion value during saturation and water absorption is 1-30, the effective components can be immersed into the expansion carrier or dissolved or dispersed in a mixture wrapping the expansion carrier, and preferably, the expansion carrier is applied in the vagina. By means of the physical properties that the expansion carrier expands according to the preset expansion value under the condition of a specified pH value in time and the like, the expansion carrier can be applied to multiple fields of medicines, cosmetics, disinfection products and the like and has good performance. For example, when the expansion carrier serves as a disinfection product, original liquid takes effects for 3-5 minutes, and the bacteriostasis rate to Escherichia coli, staphylococcus aureus and Candida sporogenes ranges from 50% to 90%.
Description
The application is dividing an application of application number is 2012104996277, the applying date is on November 29th, 2012, denomination of invention is " expansion carrier and the application thereof of carrying active component " female case.
Technical field
The invention belongs to health field, particularly a kind of expansion carrier that can carry active component.
Background technology
The new carrier with specific swelling properties is significant at food, medicine, cosmetics, sterile products, health product, health product and medical instruments field, can derive a large amount of value products.Such as common aseptic cotton sliver has purposes widely, can make the conventional medical absorbent cotton of hospital, once use the sanitary pad of the use of hygienic article, female menstrual period, also can make built-in cotton sliver of suppository etc.
Yet, in fields such as cosmetics, sterile products, medical apparatus and instruments, for the requirement of product separately, be different, the carrier that causes majority to have specific physicochemical properties can only specifically be applied to certain field and can not take into account all spectra.At present, the expansion of common absorbent cotton is random, and material is single, can not according to concrete application, select suitable product flexibly.
Although following patent has been carried out the improvement of different angles to the physical property of absorbent cotton and application, as Chinese patent CN02825892 discloses a kind of tampon in particular for feminine hygiene, Chinese patent CN88105466 discloses expansion cellulose sponge, Chinese patent CN200580022237 discloses a kind of intravaginal device of controlled expansion, Chinese patent CN200680014597 discloses a kind of dual mode absorbent tampon, and Chinese patent CN200880101828 discloses a kind of tampon that can expand by anthropometry.The application of " carrier with specific swelling properties " is narrow, material is single, the problem such as unordered that expands does not still solve completely, obtains the new expansion carrier tool significance that can carry active component.
Summary of the invention
The invention provides a kind of new expansion carrier that a plurality of fields such as medicine, cosmetics, sterile products are used that can be used as, this carrier can be made according to the difference of the active component of its carrying the products such as medicine, cosmetics or sterile products.
The expansion carrier of carrying active component of the present invention can expand by predetermined swell value in aqueous solution, the swell value of expansion carrier when saturated water suction is 1-30, and active component can be immersed in expansion carrier inside or dissolves or be dispersed in the mixture that can wrap up expansion carrier.Expansion carrier is preferably applied in vagina, but should not had the restriction of applying portion and dwindle protection scope of the present invention.
" carrying " of the present invention comprises that active component can directly or indirectly contact with expansion carrier.
" active component " of the present invention refers to the material that can act on human body performance treatment, health care, sterilization, beauty treatment, the effect such as clean.
For cosmetics, active component includes but not limited to liquid paraffin, lanoline, olive oil, card pool nurse, hyaluronic acid, white mineral oil, vaseline, lanoline, plant wet goods, Water-In-Oil (W/O) type cleansing cream and emulsion, oil-in-water (O/W) type cleansing cream and emulsion, surfactant.
For sterile products, include but not limited to chlorhexidine acetate, chitosan, formic acid, acetic acid, benzoic acid, salicylic acid, ethanol, surfactant, halogen etc.
For medicine, include but not limited to all kinds of Chinese medicine extract and ornidazole, terconazole (triaconazole), mandelic acid, bismuth gallate, chlorhexidine acetate, Oleum Curcumae, metronidazole, chloromycetin, Fructrs Hippophae seed oil, erythromycin, fibrauretin, Progesterone, furazolidone, policresulen, policresulen, povidone iodine, carboprost methylate, rehabilitation spirit, clindamycin phosphate, clotrimazole, matrine, bifonazole, morphine sulfate, sulfasalazine, Callicarpa nudiflora, U.S. pungent oxazolone, naproxen, diclofenac potassium, Pyrantel Pamoate, ftorafur, tinidazole, ketoconazole, econazole nitrate, ibuprofen, clenbuterol hydrochloride, levamisole hydrochloride, ofloxacin, nysfungin, tramadol hydrochloride, nitric acid miaow health, nonoxynolum, PGE2, meloxicam, mesalazine, ciclopirox olamine, angle dish acid esters, dinoprostone, estriol, recombinant human interferon-alpha 2 а bolts, butoconazole, fluconazol, fenticonazole, tioconazole, nystatin, itraconazole, clindamycin, tetracycline, erythromycin, doxycycline, lomefloxacin, norfloxacin, ciprofloxacin, azithromycin, cefltoxime.
" predetermined swell value " of the present invention is by selection and proportioning to the material of preparation expansion carrier, realizes the object of the swell value of pre-set expansion carrier.Pre-set swell value, can make active component can fully contact with mucosal wall with vagina epithelium, realizes selective contact.For example, a kind of material and proportioning preferably with predetermined swell value is: preparation the first expansion carrier at least comprises a kind of disappearing fibre and a kind of natural fiber and a kind of synthetic fibers, and three's ratio is 4-7:1-3:1, most preferably 5.5:2:1.Surprisingly, expansion carrier can expand by predetermined value in the aqueous solution of pH value 3.0-8.0.
In order more to adapt to the physiological structure of vagina, the different parts swell value of expansion carrier is different.The swell value of the different parts of expansion carrier also can be identical but expansion order different.
The surface that the expansion carrier of active component is carried in the present invention is provided with Os Draconis vertically or radially.In the time of vertically, the front and back end expansion order of the carrier that preferably expands different but after expanding swell value identical, first expand in the outer end (pulling out end) of optimum is expansion carrier.In the time of radially, all sites of the carrier that preferably the expands Os Draconis position swell value after expanding that simultaneously expands is greater than other positions, and optimum is the swell value maximum of outer end (the pulling out end) Os Draconis of expansion carrier, the leakproof of formation multilamellar.
" upstream end " of the present invention refers to the one end that first enters vagina; " pulling out end " of the present invention refers to while pulling out from vagina, the one end being connected with stay cord.
When swell value is different, the high expansion area of preferably preparing expansion carrier comprises a kind of natural fiber of a kind of cellulose fiber peacekeeping and a kind of synthetic fibers, three's ratio is 7:1:1, the low bulk region of preparation expansion carrier comprises a kind of natural fiber of a kind of cellulose fiber peacekeeping and a kind of synthetic fibers, and three's ratio is 4:3:1.Above-mentioned high expansion area, low bulk region can be arranged by interval, the various ways such as adjacent.
When water suction " saturated swell value " of different directions to record method identical, only the assay method of expanded radially value is for example below: with reference to two appendix of Chinese Pharmacopoeia version in 2010, melt and become time limit algoscopy, get 3 pieces of expansion carriers, in room temperature, place after 1 hour, survey respectively its tail diameter D1; 3 pieces of expansion type carriers are placed on respectively on lower floor's plectane of 3 metal rack, pack in sleeve pipe separately, and fix with hook.Said apparatus is dipped vertically into respectively in the container that fills the 37.0 ℃ ± 0.5 ℃ of water that is no less than 4L, its upper end position should fill a rot at 90mm place, underwater in container, every 10 minutes, overturn this device once in solution.After 60 minutes, while taking out from melting change time limit instrument, survey respectively immediately the rear tail diameter D2 of expansion carrier expansion, expanded radially value (S
1) computing formula be:
S
1＝D2/D1
Wherein, S
1it is the average of 3 pieces of expansion type carrier measurement results.
The expand swell value of carrier of preferred the present invention is 1-10, and is provided with bracing wire at its afterbody.Bracing wire can adopt the multiple materials such as aseptic cotton rope, PVC, PE, nylon, cloth.
The expansion carrier of carrying active component of the present invention good size in most fields is that diameter is 3.0-15.0mm, weight permissible variation 1.0-4.0g, length 10.0-60.0 ㎜, bracing wire length >=50 ㎜.The diameter of better expansion carrier is 10.0-11.0mm, weight and permissible variation 2.10-2.40g, length 43.0-46.0 ㎜, bracing wire length >=100 ㎜.
Expansion carrier of the present invention, is selected from cotton, fiber, resin, polyurethane sponge, cellulose fibre, paper, adhesive-bonded fabric, macromolecule water absorbent material, foamed materials, superabsorbents, hydrogel; Cellulose fibre comprises wood pulps, cotton, artificial silk, viscose rayon, Lyocell fiber; Fiber comprises synthetic fibers or natural fiber, and synthetic fibers comprise polyolefin, polyester, polyamide, artificial silk, high absorbent fiber, acrylic fiber, viscose rayon, regenerated celulose fibre; Natural fiber comprises Pilus Caprae seu Ovis, cotton, Caulis et Folium Lini, Fructus Cannabis, Corchorus olitorius L., Boehmeria and wood pulps.
The invention provides the good scheme of another one is, the periphery of the expansion carrier of carrying active component is enclosed with overcoat, and overcoat can limit the expansion amplitude of expansion carrier.Such as, with sterile cotton bar, as the expansion carrier that carries effect component, non-woven fabrics is as overcoat.
Provide again a good scheme to be, the inside of the expansion carrier of carrying active component of the present invention arranges built-in expansion carrier, and after expansion carrier performance expansion, built-in expansion carrier expands again, and preferably, built-in expansion carrier is more than 2 or 2.When having a plurality of built-in expansion carrier, a built-in expansion carrier can be placed in the built-in expansion carrier of another one, also can be by arranged side by side being placed in same expansion carrier or built-in expansion carrier of a plurality of built-in expansion carriers.
The part by weight of the preferred active component of the present invention and expansion carrier is 0.1: 50～50: 1, when containing built-in expansion carrier, active component and expansion carrier and built-in expansion carrier and part by weight be 0.1: 50～50: 1.
Illustrate the application of the expansion carrier of carrying active component of the present invention below.
The first is in the application as sterile products, and sterile products can be antibacterial sealing compound, and active component is to comprise that at least one is to the abstersive active component of intravaginal environment and at least one high polymer adjuvant.Active component includes but not limited to chlorhexidine acetate, chitosan, and high polymer adjuvant is Sargassum polysaccharides and liquid paraffin.Preferably application is that the weight portion of chlorhexidine acetate, chitosan is 100.
It two is in the application as cosmetics, cosmetics be by expansion carrier, add that at least one cleaning agent makes to the abstersive cleaning product of vagina.Cleaning product can also comprise that take pushing away that medicinal polyethylene or polypropylene be material helps device.
Booster color and luster uniformity, does not have obvious aberration, any surface finish, smooth, and not distortion and obviously scratch, do not have sand holes, greasy dirt.
Preferred cleaning agent comprises that the raw material of following weight portion proportioning makes: liquid paraffin 30-60%, lanoline 10-40%, olive oil 10-40%, card pool nurse 0.01-10%, hyaluronic acid 0.01-10%.
The weight portion of optimum cleaning agent consists of: liquid paraffin 44%, lanoline 27%, olive oil 28%, card pool nurse 0.5%, hyaluronic acid 0.5%.
The beneficial effect that the expansion carrier of active component is carried in the present invention is, expanding, expand under specific pH value condition and the physical property such as expansions regularly by predetermined swell value of its uniqueness, makes it can be used as the new expansion carrier of a plurality of fields use such as medicine, cosmetics, sterile products.And during lot of experiments proof application different field, all have good performance, when doing as described in Example 1 sterile products, stock solution effect 3-5 minute, to the bacteriostasis rate of escherichia coli, staphylococcus aureus, candida albicans all 50%～90%.
Accompanying drawing explanation
The expansion carrier structure schematic diagram of the carrying active component of Fig. 1, the embodiment of the present invention 1;
The expansion carrier structure schematic diagram of the carrying active component of Fig. 2, the embodiment of the present invention 2;
The expansion carrier expansion pre-structure schematic diagram of Fig. 3, the embodiment of the present invention 3;
Structural representation after the expansion carrier of Fig. 4, the embodiment of the present invention 3 expands;
The front view of Fig. 5, booster of the present invention;
Fig. 6, booster of the present invention disassemble schematic diagram.
The specific embodiment
The antibacterial sealing compound of embodiment 1
As shown in Figure 1, the expansion carrier 11 of carrying active component of the present invention, is according to 5.5:2:1, to be the body 12 that material is made by cellulose fibre, Corchorus olitorius L. and viscose rayon, and cellulose fibre provides for Shanghai Luo Yang new material Science and Technology Ltd..Some Os Draconis 13 are arranged on the surface of body 12 vertically, pull out end and first expand, and pulling out end is identical with the swell value of upstream end.One end of expansion carrier is with cotton cord 14.
The active component that this expansion carrier carries is that weight ratio is chlorhexidine acetate, the chitosan of 100:100, and Sargassum polysaccharides and liquid paraffin.
The entrained stock solution of this antibacterial sealing compound acts on intravaginal 3-5 minute, to the bacteriostasis rate of escherichia coli, staphylococcus aureus, candida albicans all 50%～90%.
Embodiment 2 cleaning products
As shown in Figure 2, the expansion carrier 21 of carrying active component of the present invention, the surface of body 22 is along neck to arranging some Os Draconis 23.Os Draconis 23 are high breathing space, and all the other are low bulk district.The high expansion area of preparation expansion carrier comprises cellulose fibre, cotton and viscose rayon, and three's ratio is 7:1:1, and the low bulk region of preparation expansion carrier comprises cellulose fibre, cotton and viscose rayon, and three's ratio is 4:3:1.Cellulose fibre provides for Shanghai Luo Yang new material Science and Technology Ltd..Pull out end and upstream end and expand simultaneously, but swell value is different.
The entrained active component of the present embodiment expansion carrier is liquid paraffin 44%, lanoline 27%, olive oil 28%, card pool nurse 0.5%, hyaluronic acid 0.5%.
The limited expansion carrier of embodiment 3
As shown in Figure 3, state before the expansion carrier 31 of carrying active component of the present invention expands, the periphery that comprises the aseptic cotton sliver 32 that carries active component is enclosed with 3 non-woven fabrics 33, in conjunction with state after the expansion shown in Fig. 4, shows that non-woven fabrics can limit the expansion amplitude of aseptic cotton sliver.
Embodiment 4
Substantially the same manner as Example 1, difference is that material is aseptic cotton sliver.The diameter of best expansion carrier is 10.0mm, weight and permissible variation 2.20g, length 43.0 ㎜, bracing wire length 150 ㎜.
Embodiment 5
Substantially the same manner as Example 2, difference is that material is aseptic cotton sliver.The diameter of best expansion carrier is 11.0mm, deviation of weight 2.40g, length 46.0 ㎜, bracing wire length 200 ㎜.
Embodiment 6
Propeller 61 as described in Fig. 5,6, comprises propeller main body 63, and can be at the pull bar 62 of propeller main body 63 interior push-and-pulls, and propeller main body 63 inside are cavity, and outside is handle 64 above, and outside is connected with sleeve pipe 65 below.
The above embodiment is only that the preferred embodiment of the present invention is described; not scope of the present invention is limited; design under the prerequisite of spirit not departing from the present invention; various distortion and improvement that those of ordinary skills make technical scheme of the present invention, all should fall in the definite protection domain of claims of the present invention.
Claims (10)
1. an expansion carrier that carries active component, it is characterized in that, described expansion carrier comprises high breathing space and low bulk district, the high expansion area of preparing described expansion carrier comprises a kind of cellulose fibre, cotton and viscose rayon, three's ratio is 7:1:1, the low bulk region of preparing described expansion carrier comprises a kind of cellulose fibre, cotton and viscose rayon, and three's ratio is 4:3:1.
2. the application of a kind of expansion carrier that carries active component as claimed in claim 1 in preparing cosmetics, described cosmetics be by expansion carrier, add that at least one cleaning agent makes to the abstersive cleaning product of vagina; Described cleaning agent comprises that the raw material of following weight portion proportioning makes: liquid paraffin 30-60, lanoline 10-40, olive oil 10-40, card pool nurse 0.01-10, hyaluronic acid 0.01-10; Further the weight portion of preferred described cleaning agent consists of: liquid paraffin 44, lanoline 27, olive oil 28, card pool nurse 0.5, hyaluronic acid 0.5.
3. the expansion carrier of carrying active component as claimed in claim 3, is characterized in that, the afterbody of described expansion carrier is provided with bracing wire; Axially or radially there are some Os Draconis (13) on surface along described expansion carrier.
4. the expansion carrier of the carrying active component as described in as arbitrary in claim 1-3, is characterized in that, the different parts swell value of described expansion carrier is identical but expansion order different, first expands in the outer end of the carrier that preferably expands.
5. the expansion carrier of the carrying active component as described in as arbitrary in claim 1-3, is characterized in that, the different parts swell value of described expansion carrier is different, and preferably, the swell value of Os Draconis is large.
6. the expansion carrier of the carrying active component as described in as arbitrary in claim 1-3, it is characterized in that, the diameter of described expansion carrier is 3.0-15.0mm, deviation of weight 1.0-4.0g, length 10.0-60.0 ㎜, bracing wire length>=50 ㎜, preferably, the diameter of described expansion carrier is 10.0-11.0mm, deviation of weight 2.10-2.40
g, length 43.0-46.0 ㎜, bracing wire length>=100 ㎜.
7. the expansion carrier of the carrying active component as described in as arbitrary in claim 1-3, is characterized in that, the periphery of described expansion carrier is enclosed with overcoat, and described overcoat can limit the expansion amplitude of expansion carrier.
8. the expansion carrier of carrying active component as claimed in claim 7, is characterized in that, described expansion carrier is cotton sliver, and described overcoat is non-woven fabrics.
9. the expansion carrier of the carrying active component as described in as arbitrary in claim 1-3, is characterized in that, the inside of described expansion carrier arranges built-in expansion carrier, and after described expansion carrier performance expansion, built-in expansion carrier expands again.
10. the expansion carrier of carrying active component as claimed in claim 9, is characterized in that, described built-in expansion carrier is more than 2 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410271348.4A CN104001179B (en) | 2012-11-29 | 2012-11-29 | To the abstersive cleaning products of vagina |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410271348.4A CN104001179B (en) | 2012-11-29 | 2012-11-29 | To the abstersive cleaning products of vagina |
| CN201210499627.7A CN102961260B (en) | 2012-11-29 | 2012-11-29 | Expansion carrier bearing active components and application thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210499627.7A Division CN102961260B (en) | 2012-11-29 | 2012-11-29 | Expansion carrier bearing active components and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104001179A true CN104001179A (en) | 2014-08-27 |
| CN104001179B CN104001179B (en) | 2017-10-31 |
Family
ID=51362262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410271348.4A Active CN104001179B (en) | 2012-11-29 | 2012-11-29 | To the abstersive cleaning products of vagina |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104001179B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104264278A (en) * | 2014-09-25 | 2015-01-07 | 哈尔滨欧替药业有限公司 | Viscose with moisture-absorbing, crimpness and moisture regaining performances for suppository carrier |
| WO2018196040A1 (en) * | 2017-04-27 | 2018-11-01 | 哈尔滨欧替药业有限公司 | Expansion suppository body for vagina and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080262463A1 (en) * | 2007-04-18 | 2008-10-23 | The Procter & Gamble Company | Tampon having at least one physical discontinuity |
-
2012
- 2012-11-29 CN CN201410271348.4A patent/CN104001179B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080262463A1 (en) * | 2007-04-18 | 2008-10-23 | The Procter & Gamble Company | Tampon having at least one physical discontinuity |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104264278A (en) * | 2014-09-25 | 2015-01-07 | 哈尔滨欧替药业有限公司 | Viscose with moisture-absorbing, crimpness and moisture regaining performances for suppository carrier |
| CN104264278B (en) * | 2014-09-25 | 2016-04-20 | 哈尔滨欧替药业有限公司 | A kind of have the viscose of the curling moisture regain performance of moisture absorption for suppository carrier |
| WO2018196040A1 (en) * | 2017-04-27 | 2018-11-01 | 哈尔滨欧替药业有限公司 | Expansion suppository body for vagina and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104001179B (en) | 2017-10-31 |
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Effective date of registration: 20211118 Address after: 150040 office building 7, Bohai Third Road, haping road concentration area, Harbin Economic Development Zone, Harbin, Heilongjiang Province Patentee after: Harbin Tianmei Pharmaceutical Co.,Ltd. Address before: 150069, No. three, No. 7, Bohai, Harbin, Heilongjiang, China Patentee before: HARBIN OT PHARMACEUTICALS Co.,Ltd. Patentee before: Qiu Mingshi |
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Denomination of invention: Cleaning products that have a cleaning effect on the vagina Effective date of registration: 20230704 Granted publication date: 20171031 Pledgee: Harbin Kechuang Financing Guarantee Co.,Ltd. Pledgor: Harbin Tianmei Pharmaceutical Co.,Ltd. Registration number: Y2023230000060 |