CN103998014A - 脱毛组合物 - Google Patents
脱毛组合物 Download PDFInfo
- Publication number
- CN103998014A CN103998014A CN201280056065.7A CN201280056065A CN103998014A CN 103998014 A CN103998014 A CN 103998014A CN 201280056065 A CN201280056065 A CN 201280056065A CN 103998014 A CN103998014 A CN 103998014A
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- CN
- China
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- depilatory
- compositions
- depilatory composition
- composition
- Prior art date
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- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 90
- 230000002951 depilatory effect Effects 0.000 claims abstract description 64
- 150000001875 compounds Chemical class 0.000 claims abstract description 21
- 239000004475 Arginine Substances 0.000 claims abstract description 14
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 33
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 27
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 24
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 18
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 11
- 239000004202 carbamide Substances 0.000 claims description 11
- 229920001577 copolymer Polymers 0.000 claims description 11
- 229910052700 potassium Inorganic materials 0.000 claims description 11
- 239000011591 potassium Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000002537 cosmetic Substances 0.000 claims description 10
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- MSXHSNHNTORCAW-GGLLEASOSA-M sodium;(2s,3s,4s,5r,6s)-3,4,5,6-tetrahydroxyoxane-2-carboxylate Chemical compound [Na+].O[C@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O MSXHSNHNTORCAW-GGLLEASOSA-M 0.000 claims description 10
- 239000004115 Sodium Silicate Substances 0.000 claims description 9
- -1 hydrogen salt Chemical class 0.000 claims description 9
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 9
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 9
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 9
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 8
- GYXHHICIFZSKKZ-UHFFFAOYSA-N 2-sulfanylacetamide Chemical compound NC(=O)CS GYXHHICIFZSKKZ-UHFFFAOYSA-N 0.000 claims description 6
- 229920006037 cross link polymer Polymers 0.000 claims description 6
- 230000000593 degrading effect Effects 0.000 claims description 5
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims description 5
- IZFHEQBZOYJLPK-SSDOTTSWSA-N (R)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@@H](S)CCS IZFHEQBZOYJLPK-SSDOTTSWSA-N 0.000 claims description 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 4
- VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 claims description 4
- 125000005456 glyceride group Chemical group 0.000 claims description 4
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 claims description 2
- FCGXLCNBWYIEAA-UHFFFAOYSA-N 1,3-benzothiazol-6-ylmethanamine Chemical compound NCC1=CC=C2N=CSC2=C1 FCGXLCNBWYIEAA-UHFFFAOYSA-N 0.000 claims description 2
- GJKRQHARSBOIBU-UHFFFAOYSA-N 1,3-bis(sulfanyl)propan-1-ol Chemical compound OC(S)CCS GJKRQHARSBOIBU-UHFFFAOYSA-N 0.000 claims description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 2
- DKIDEFUBRARXTE-UHFFFAOYSA-N 3-mercaptopropanoic acid Chemical compound OC(=O)CCS DKIDEFUBRARXTE-UHFFFAOYSA-N 0.000 claims description 2
- PQJUJGAVDBINPI-UHFFFAOYSA-N 9H-thioxanthene Chemical compound C1=CC=C2CC3=CC=CC=C3SC2=C1 PQJUJGAVDBINPI-UHFFFAOYSA-N 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- LXXNWCFBZHKFPT-UHFFFAOYSA-N Ethyl 2-mercaptopropionate Chemical compound CCOC(=O)C(C)S LXXNWCFBZHKFPT-UHFFFAOYSA-N 0.000 claims description 2
- 102000011782 Keratins Human genes 0.000 claims description 2
- 108010076876 Keratins Proteins 0.000 claims description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 2
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims description 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 2
- 229960004308 acetylcysteine Drugs 0.000 claims description 2
- 229920000180 alkyd Polymers 0.000 claims description 2
- AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims description 2
- PMNLUUOXGOOLSP-UHFFFAOYSA-N alpha-mercaptopropionic acid Natural products CC(S)C(O)=O PMNLUUOXGOOLSP-UHFFFAOYSA-N 0.000 claims description 2
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims description 2
- 235000019270 ammonium chloride Nutrition 0.000 claims description 2
- ZZTCCAPMZLDHFM-UHFFFAOYSA-N ammonium thioglycolate Chemical compound [NH4+].[O-]C(=O)CS ZZTCCAPMZLDHFM-UHFFFAOYSA-N 0.000 claims description 2
- VHFSMDHANDABQK-UHFFFAOYSA-N azane;2-sulfanylpropanoic acid Chemical compound [NH4+].CC(S)C([O-])=O VHFSMDHANDABQK-UHFFFAOYSA-N 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- CNYFJCCVJNARLE-UHFFFAOYSA-L calcium;2-sulfanylacetic acid;2-sulfidoacetate Chemical compound [Ca+2].[O-]C(=O)CS.[O-]C(=O)CS CNYFJCCVJNARLE-UHFFFAOYSA-L 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 2
- 150000002009 diols Chemical class 0.000 claims description 2
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 claims description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 2
- 235000003969 glutathione Nutrition 0.000 claims description 2
- 229960003180 glutathione Drugs 0.000 claims description 2
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 2
- 108010059345 keratinase Proteins 0.000 claims description 2
- 235000019136 lipoic acid Nutrition 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- 229960003151 mercaptamine Drugs 0.000 claims description 2
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims description 2
- 229960005480 sodium caprylate Drugs 0.000 claims description 2
- 238000005987 sulfurization reaction Methods 0.000 claims description 2
- 229960002663 thioctic acid Drugs 0.000 claims description 2
- 229940035024 thioglycerol Drugs 0.000 claims description 2
- NJRXVEJTAYWCQJ-UHFFFAOYSA-N thiomalic acid Chemical compound OC(=O)CC(S)C(O)=O NJRXVEJTAYWCQJ-UHFFFAOYSA-N 0.000 claims description 2
- NBOMNTLFRHMDEZ-UHFFFAOYSA-N thiosalicylic acid Chemical compound OC(=O)C1=CC=CC=C1S NBOMNTLFRHMDEZ-UHFFFAOYSA-N 0.000 claims description 2
- 229940103494 thiosalicylic acid Drugs 0.000 claims description 2
- KNRGNPYMOIKFMS-UHFFFAOYSA-N 2-aminoethanol;2-sulfanylpropanoic acid Chemical compound [NH3+]CCO.CC(S)C([O-])=O KNRGNPYMOIKFMS-UHFFFAOYSA-N 0.000 claims 1
- YZLINCYMFOTLMY-UHFFFAOYSA-M potassium acetic acid sulfanide Chemical compound [SH-].[K+].CC(O)=O YZLINCYMFOTLMY-UHFFFAOYSA-M 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 10
- 235000009697 arginine Nutrition 0.000 description 8
- 235000002639 sodium chloride Nutrition 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 5
- 229910021641 deionized water Inorganic materials 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 4
- 229930064664 L-arginine Natural products 0.000 description 4
- 235000014852 L-arginine Nutrition 0.000 description 4
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 4
- 239000000920 calcium hydroxide Substances 0.000 description 4
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 4
- 229940073669 ceteareth 20 Drugs 0.000 description 4
- 239000003974 emollient agent Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 210000004209 hair Anatomy 0.000 description 3
- 229940097789 heavy mineral oil Drugs 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- XTJCJAPNPGGFED-UHFFFAOYSA-N 2-hydroxyethylazanium;2-sulfanylacetate Chemical compound [NH3+]CCO.[O-]C(=O)CS XTJCJAPNPGGFED-UHFFFAOYSA-N 0.000 description 2
- 229940081733 cetearyl alcohol Drugs 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000035617 depilation Effects 0.000 description 2
- FSBVERYRVPGNGG-UHFFFAOYSA-N dimagnesium dioxido-bis[[oxido(oxo)silyl]oxy]silane hydrate Chemical compound O.[Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O FSBVERYRVPGNGG-UHFFFAOYSA-N 0.000 description 2
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 2
- 239000000391 magnesium silicate Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 229910001413 alkali metal ion Inorganic materials 0.000 description 1
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- RZOXALOSBVDYRY-UHFFFAOYSA-N azane;2-(carboxymethyldisulfanyl)acetic acid Chemical compound [NH4+].[NH4+].[O-]C(=O)CSSCC([O-])=O RZOXALOSBVDYRY-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 229940094522 laponite Drugs 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
- 235000019793 magnesium trisilicate Nutrition 0.000 description 1
- 229940099273 magnesium trisilicate Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q9/00—Preparations for removing hair or for aiding hair removal
- A61Q9/04—Depilatories
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
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Abstract
本发明涉及一种脱毛组合物，其包含具有巯基的脱毛化合物；和占组合物的总重量为至少0.1重量％的精氨酸。
Description
本发明涉及一种脱毛组合物，其包含具有巯基的脱毛化合物、包含马来酸酐的交联聚合物和精氨酸，还涉及使用这样的组合物脱毛的方法。特别地，本发明涉及刺激显著降低的脱毛凝胶。
包含降解毛发角蛋白的化合物的用于除去身体多余毛发的组合物是已知的。在施用所述组合物之后，使其保留在皮肤上以降解毛发，并且随后与降解的毛发一同除去。
这种类型的脱毛组合物典型地包含具有巯基的脱毛化合物例如巯基乙酸钾，其还典型地含有氢氧化钠以提供高的pH值。然而，使用这些化合物有一个显著的缺点，即，这些化合物会由于高的pH值(通常在12以上)而刺激并且甚至损伤皮肤。
WO 9844898公开了难闻气味减少的脱毛组合物，其中将极低水平的精氨酸与聚乙烯亚胺组合使用来实现对组合物的缓冲。
令人惊讶地发现，加入超过且高于用于缓冲的水平的精氨酸极大地减少了皮肤刺激。
根据本申请的第一方面，描述了一种脱毛组合物，其包含：
·具有巯基的脱毛化合物；和
·占所述组合物的总重量为至少0.1重量％的精氨酸。
优选地，如上所述的脱毛组合物包含占所述组合物的总重量为0.5重量％至5重量％的精氨酸。
更优选地，如上所述的脱毛组合物包含占所述组合物的总重量为2.0重量％至4.0重量％的精氨酸。
在本发明的一个方面，脱毛产品可以为凝胶的形式。
当根据本发明的脱毛组合物为凝胶形式时，其优选地包含含有马来酸酐的交联共聚物。
优选地，所述交联组合物的存在量为所述组合物的总重量的1.5重量％至5重量％；更优选地，为所述组合物的总重量的2重量％至3重量％。
在如上所述的优选脱毛组合物中，所述交联共聚物还包含甲基乙烯基醚。
更优选地，如上描述的脱毛组合物所包含的交联聚合物为与1，9癸二烯交联的聚(甲基乙烯基醚/马来酸酐)共聚物。
在本发明的另一方面，脱毛产品可以为霜的形式。
脱毛化合物的量存在优选地为所述组合物的总重量的2重量％至10重量％，更优选地为3重量％至7重量％。
脱毛组合物还包含选自下述盐的盐：二价盐和三价盐，例如氯化镁、氯化钙、氯化铵、硫酸镁、硫酸钙、硫酸铝、碳酸镁、硫酸钙、碳酸钙。优选的盐是氯化镁。在替代性实施方式中，所述组合物可以包含盐提取物，例如死海盐。
所述具有巯基的脱毛化合物可以为能够降解角蛋白的任何化合物。这类化合物的实例为巯基乙酸钾、二硫赤藓糖醇、硫代甘油、硫甘醇(thioglycol)、硫代黄嘌呤、硫代水杨酸、N-乙酰基-L-半胱氨酸、硫辛酸、二氢硫辛酸钠6，8-二硫代辛酸酯(sodiumdihydrolipoate6，8-dithioocatanoate)、6，8-二硫代辛酸钠、硫化氢盐(hydrogen sulphidesalt)、巯基乙酸、2-巯基丙酸、3-巯基丙酸、巯基苹果酸、巯基乙酸铵、单巯基乙酸甘油酯、巯基乙酸单乙醇胺酯(monoethanolamine thioglycolate)、单乙醇胺巯基乙酸(monoethanolamine thioglycolic acid)、二硫代二乙醇酸二铵(diammoniumdithiodiglycolate)、硫代乳酸铵、硫代乳酸单乙醇胺酯、巯基乙酰胺(thioglycolamide)、高半胱氨酸、半胱氨酸、谷胱甘肽、二硫苏糖醇、二氢硫辛酸、1，3-二巯基丙醇、巯基乙酰胺(thioglycolamide)、单巯基乙酸甘油酯、硫甘醇肼(thioglycolhydrazine)、角蛋白酶、巯基乙酸胍、巯基乙酸钙和/或半胱胺。可以使用单独的化合物或者两种或多种化合物的混合物。
优选地，脱毛化合物是巯基乙酸钾。
如果需要，脱毛组合物可以包含其他的组分。
脱毛组合物可以例如包含促进角蛋白降解反应的组分，例如脲、硫脲、二硫赤藓糖醇、二甲基异山梨醇(DMI)、乙氧基二甘醇(Transcutol)或甲基丙基二醇(MT diol)。所述组合物理想地包含占所述组合物的总重量为至多15重量％的促进剂，优选地0.2重量％至15重量％，以及更优选地0.5重量％至10重量％。
所述组合物可以包含碱度源。其可以包含氢氧化物，例如碱金属和碱土金属的氢氧化物。适合的氢氧化物包含氢氧化钠、氢氧化钾、氢氧化钙和氢氧化镁。优选地，使用氢氧化钾，其可选地与氢氧化钙一起使用。所述碱度源(例如氢氧化钙)的存在量可以为脱毛霜组合物的0.1重量％至10重量％，优选地1重量％至6重量％，例如2重量％至5重量％。
脱毛组合物优选地具有大于7的pH值，例如9至12.7的pH值。
优选地，碱金属氢氧化物的存在量为至少0.001mol/100g组合物，优选地以至少0.0lmol/100g组合物。
本发明的所述脱毛组合物可以包含水，水的适合量为所述组合物总重量的至少40重量％或50重量％，更优选地至少60重量％。
脱毛组合物还可以包含湿润剂。适合的湿润剂包含多元醇，例如甘油、丙二醇和丁二醇。甘油是优选的。湿润剂的存在量可以为至多10重量％，优选地0.5重量％至5重量％。
脱毛组合物还可以包含润肤剂，例如油或蜡。优选的油质润肤剂为矿物油。优选的蜡质润肤剂为鲸蜡硬脂醇聚醚-20(ceteareth-20)。所述脱毛霜组合物可以包含油和蜡的混合物作为组合润肤剂。
可以加入到组合物中的其它适合的组分包含缓冲剂，例如硅酸钠或硅酸镁，芳香剂例如莲子乳(lotus milk)，以及螯合剂例如葡萄糖酸钠。
在本发明的一个特别优选的方面，提供一种凝胶形式的脱毛组合物，其包含：
(a)1重量％至5重量％的与1，9癸二烯交联的聚(甲基乙烯基醚/马来酸酐)共聚物；
(b)0.5重量％至5％重量的精氨酸；
(c)0.01重量％至1重量％的无机盐；
(d)0至10重量％的甘油；
(e)5重量％至10重量％的脲；
(f)0.01重量％至1重量％的葡萄糖酸钠；
(g)0.01重量％至1重量％的化妆用提取物(cosmetic extract)；
(h)2重量％至15重量％的巯基乙酸钾水溶液；
(i)0至5重量％的硅酸钠溶液；
(j)1重量％至5重量％的氢氧化钾；和
(k)水，加至100％。
特别地，所述脱毛组合物包含：
(a)2.2重量％的与1，9癸二烯交联的聚(甲基乙烯基醚/马来酸酐)共聚物；
(b)3.0％重量的精氨酸；
(c)0.1重量％的氯化镁；
(d)3重量％的甘油；
(e)1重量％的脲；
(f)0.1重量％的葡萄糖酸钠；
(g)0.1重量％的化妆用提取物；
(h)5重量％的巯基乙酸钾；
(i)2.5重量％的硅酸钠溶液；
(j)8重量％的氢氧化钾50％溶液；和
(k)水，加至100％。
特别优选基本上由组分(a)至(k)组成的脱毛组合物。
下面，将描述本发明的示例性实施方式。
比较例1
| 组分(商品名) | 重量％ |
| Stabileze QM | 2.2 |
| 氯化镁 | 0.05 |
| 甘油 | 5 |
| 脲 | 8 |
| 葡萄糖酸钠 | 0.1 |
| 化妆用提取物 | 0.1 |
| 巯基乙酸钾溶液(43重量％) | 12 |
| 硅酸钠溶液 | 2.5 |
| KOH50％溶液 | 7.7 |
| 去离子水 | 至100 |
本发明实施例1
| 组分(商品名) | 重量％ |
| Stabilize QM | 2.2 |
| 甘油 | 3 |
| 脲 | 0.5 |
| 葡萄糖酸钠 | 0.1 |
| 莲子乳提取物 | 0.1 |
| 巯基乙酸钾溶液(43％) | 12 |
| 硅酸钠溶液 | 2.5 |
| KOH50％溶液 | 8.2 |
| 去离子水 | 至100 |
| L-精氨酸 | 3 |
| 芳香剂 | 0.5 |
| 化妆用提取物 | 0.1 |
| 着色剂 | 适量 |
本发明实施例2
| 组分(商品名) | 制剂中的重量％ |
| 去离子水 | 至100 |
| 巯基乙酸钾溶液43％ | 12 |
| 氢氧化钾50％ | 8.5 |
| 甘油 | 3 |
| 硅酸钠 | 2.5 |
| Stabilize QM | 2.2 |
| 脲 | 0.5 |
| 芳香剂 | 0.5 |
| 化妆用提取物 | 0.1 |
| 葡萄糖酸钠 | 0.1 |
| 氯化镁 | 0.05 |
| 着色剂 | 适量 |
| 重质矿物油(Thick Mineral Oil) | 2 |
| L-精氨酸 | 3 |
本发明实施例3
| 组分(商品名) | 制剂中的重量％ |
| 去离子水 | 至100 |
| 巯基乙酸钾43％ | 12 |
| 氢氧化钾50％ | 8.5 |
| 甘油 | 3 |
| 硅酸钠 | 2.5 |
| Stabilize QM | 2.2 |
| 脲 | 0.5 |
| 芳香剂 | 0.5 |
| 化妆用提取物 | 0.1 |
| 葡萄糖酸钠 | 0.1 |
| 氯化镁 | 0.05 |
| 着色剂 | 适量 |
| 重质矿物油 | 0.6 |
| 鲸蜡硬脂醇 | 1 |
| 鲸蜡硬脂醇聚醚-20 | 0.4 |
| L-精氨酸 | 3 |
本发明实施例4(霜产品)
| 组分(商品名) | 制剂中的重量％ |
| 重质矿物油 | 4.8 |
| 山梨醇 | 1 |
| 甘油 | 1 |
| 鲸蜡硬脂醇 | 4.4 |
| 鲸蜡硬脂醇聚醚-20 | 1.76 |
| 氢氧化钙 | 3.56 |
| 滑石 | 2 |
| 三硅酸镁 | 0.5 |
| 葡萄糖酸钠 | 0.1 |
| 化妆用提取物 | 0.1 |
| 色浆 | 0.6 |
| Laponite XLG | 0.2 |
| 脲 | 8 |
| 丙烯酸酯共聚物 | 0.1 |
| 芳香剂 | 0.4 |
| 硅胶 | 0.025 |
| 巯基乙酸钾43％ | 12.9 |
| 氢氧化钾50％ | 0.5 |
| L-精氨酸 | 1 |
| 去离子水 | 至100％ |
Stabilize QM是一种交联的甲基乙烯基醚/马来酸酐共聚物。
根据所述实施例的组合物与不含有精氨酸的凝胶比较，证实当接触人的皮肤时本发明的组合物减少刺激的能力。测试的组合物显示在下表1中，而结果显示在表2中。
使用体外方法，其中用不同实施例产品处理细胞测试。
该测试在每种情形中测定细胞减少50％所需的时间(ET-50)。这是抗刺激的关键5度量，因为当细胞被组合物的高pH所破坏时，其为对细胞存活的直接度量。
在此给出的结果是基于不同暴露时间的多次测量。
表1-用于体外测试的实施例(以及比较例1，表2中的编号(4))
表2-体外测试结果
Claims (21)
1.一种脱毛组合物，所述脱毛组合物包含：
·具有巯基的脱毛化合物；和
·占所述组合物的总重量为至少0.1重量％的精氨酸。
2.如权利要求1所述的脱毛组合物，所述脱毛组合物为凝胶剂的形式，并且还包含含有马来酸酐的交联共聚物。
3.如权利要求1或2所述的脱毛组合物，所述脱毛组合物包含占所述组合物的总重量为0.5重量％至5重量％的精氨酸。
4.如前述权利要求中任一项所述的脱毛组合物，所述脱毛组合物包含占所述组合物的总重量为2.0重量％至4.0重量％的精氨酸。
5.如权利要求2至4中任一项所述的脱毛组合物，其中，所述交联聚合物在所述组合物中的存在量为所述组合物总重量的1.5重量％至5重量％。
6.如权利要求5所述的脱毛组合物，其中，所述交联聚合物在所述组合物中的存在量为所述组合物总重量的2重量％至3重量％。
7.如权利要求2至6中任一项所述的脱毛组合物，其中，所述交联聚合物还包含甲基乙烯基醚。
8.如权利要求2至7中任一项所述的脱毛组合物，其中，所述交联聚合物为与1，9癸二烯交联的聚(甲基乙烯基醚/马来酸酐)共聚物。
9.如权利要求1所述的脱毛组合物，所述脱毛组合物为霜剂的形式。
10.如前述权利要求中任一项所述的脱毛组合物，其中，所述组合物还包含选自下述盐的盐：二价或三价盐，例如氯化镁、氯化钙、氯化铵、硫酸镁、硫酸钙、硫酸铝、碳酸镁、硫酸钙、碳酸钙。
11.如权利要求10所述的脱毛组合物，其中，所述盐是氯化镁。
12.如前述权利要求中任一项所述的脱毛组合物，其中，所述具有巯基的脱毛化合物是能够降解角蛋白的任何化合物。
13.如权利要求10所述的脱毛组合物，其中，所述脱毛化合物选自巯基乙酸钾、二硫赤藓糖醇、硫代甘油、硫甘醇、硫代黄嘌呤、硫代水杨酸、N-乙酰基-L-半胱氨酸、硫辛酸、二氢硫辛酸钠6，8-二硫代辛酸酯、6，8-二硫代辛酸钠、硫化氢盐、巯基乙酸、2-巯基丙酸、3-巯基丙酸、巯基苹果酸、巯基乙酸铵、单巯基乙酸甘油酯、巯基乙酸单乙醇胺酯、单乙醇胺巯基乙酸、二硫代二乙醇酸二铵、硫代乳酸铵、硫代乳酸单乙醇胺、巯基乙酰胺、高半胱氨酸、半胱氨酸、谷胱甘肽、二硫苏糖醇、二氢硫辛酸、1，3-二巯基丙醇、巯基乙酰胺、单巯基乙酸甘油酯、硫甘醇肼、角蛋白酶、巯基乙酸胍、巯基乙酸钙和/或半胱胺。
14.如权利要求13所述的脱毛组合物，其中，所述脱毛化合物为巯基乙酸钾。
15.如前述权利要求中任一项所述的脱毛组合物，其中，所述脱毛化合物在所述组合物中的存在量为所述组合物总重量的2重量％至10重量％。
16.如前述权利要求中任一项所述的脱毛组合物，其中，所述脱毛化合物在所述组合物中的存在量为3重量％至7重量％。
17.如前述权利要求中任一项所述的脱毛组合物，其中，所述组合物包含促进角蛋白降解反应的组分，例如脲、硫脲、二硫赤藓糖醇、异山梨醇二甲醚(DMI)、乙氧基二甘醇(Transcutol)或甲基丙基二醇(MT diol)。
18.如权利要求17所述的脱毛组合物，其中，所述组合物包含占所述组合物的总重量为至多15重量％的促进剂。
19.如权利要求2至8和10至18中任一项所述的脱毛组合物，所述脱毛组合物包含：
(a)1重量％至5重量％的与1，9癸二烯交联的聚(甲基乙烯基醚/马来酸酐)共聚物；
(b)0.5重量％至5重量％的精氨酸；
(c)0.01重量％至1重量％的无机盐；
(d)0至10重量％的甘油；
(e)0至10重量％的脲；
(f)0.01重量％至1重量％的葡萄糖酸钠；
(g)0.01重量％至1重量％的化妆用提取物；
(h)2重量％至10重量％的巯基乙酸钾；
(i)0重量％至5重量％的硅酸钠溶液；
(j)1重量％至5重量％的氢氧化钾；和
(k)水，加至100％。
20.如权利要求19所述的脱毛组合物，其中，所述组合物包含：
(a)2.2重量％的与1，9癸二烯交联的聚(甲基乙烯基醚/马来酸酐)共聚物；
(b)3.0％重量的精氨酸；
(c)0.1重量％的氯化镁；
(d)3重量％的甘油；
(e)1重量％的脲；
(f)0.1重量％的葡萄糖酸钠；
(g)0.1重量％的化妆用提取物；
(h)5.2重量％的巯基乙酸钾；
(i)2.5重量％的硅酸钠溶液；
(j)8重量％的氢氧化钾50％溶液；和
(k)水，加至100％。
21.如权利要求17或18中任一项所述的组合物，其基本上由组分(a)-(k)组成。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1119601.1 | 2011-11-14 | ||
| GB201119601A GB2496447B (en) | 2011-11-14 | 2011-11-14 | Compositions |
| PCT/GB2012/052814 WO2013072674A2 (en) | 2011-11-14 | 2012-11-13 | Compositions |
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| Publication Number | Publication Date |
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| CN103998014A true CN103998014A (zh) | 2014-08-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201280056065.7A Pending CN103998014A (zh) | 2011-11-14 | 2012-11-13 | 脱毛组合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20140309308A1 (zh) |
| EP (1) | EP2779986A2 (zh) |
| CN (1) | CN103998014A (zh) |
| AU (1) | AU2012338550B2 (zh) |
| BR (1) | BR112014011460A2 (zh) |
| GB (1) | GB2496447B (zh) |
| IN (1) | IN2014CN04291A (zh) |
| MX (1) | MX2014005849A (zh) |
| RU (1) | RU2602187C2 (zh) |
| WO (1) | WO2013072674A2 (zh) |
| ZA (1) | ZA201403398B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116904275A (zh) * | 2023-06-30 | 2023-10-20 | 广州市爱家有方日用品有限公司 | 一种生物酶催化分解管道疏通剂及其制备方法 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10463692B2 (en) * | 2014-03-07 | 2019-11-05 | Amy Dukoff | Composition and method of using medicament for treatment of cancers and tumors |
| US9642783B2 (en) | 2014-04-02 | 2017-05-09 | L'oreal | Depilatory compositions |
| RU2712049C2 (ru) * | 2017-10-13 | 2020-01-24 | Кривоносова Нина Ивановна | Комплексная биологически активная добавка для подавления роста волос и способ ее использования |
| RU2697880C1 (ru) * | 2018-05-15 | 2019-08-21 | Общество с ограниченной ответственностью "МЕРЕЯ КОСМЕТИКС" | Средство для удаления волос (варианты) |
| RU2704036C1 (ru) * | 2018-10-05 | 2019-10-23 | Екатерина Сергеевна Пигалева | Сахарная паста для депиляции |
| JP7511973B2 (ja) | 2020-03-24 | 2024-07-08 | 株式会社マンダム | 除毛剤組成物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998044898A1 (en) * | 1997-04-09 | 1998-10-15 | Reckitt & Colman France | Depilatory compositions, their preparation and use |
| GB2367749A (en) * | 1997-07-09 | 2002-04-17 | Reckitt Benckiser France | Depilatory compositions |
| CN1809336A (zh) * | 2003-05-02 | 2006-07-26 | 荷兰联合利华有限公司 | 用于减少皮肤脱毛组合物刺激性的方法和试剂盒 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06192056A (ja) * | 1992-12-25 | 1994-07-12 | Sekisui Chem Co Ltd | 除毛材 |
| US5500210A (en) * | 1994-05-23 | 1996-03-19 | The Gillette Company | Combined two-part reducing agent/humectant shaving system for improved shaving comfort |
| FR2743813B1 (fr) * | 1996-01-23 | 1998-02-20 | Oreal | Composition gelifiee stable a forte teneur en electrolyte |
| GB9720372D0 (zh) * | 1997-07-09 | 1997-11-26 | Reckitt & Colman France | |
| US20050048090A1 (en) * | 2003-09-03 | 2005-03-03 | Rau Allen H. | Temperature changing skin care product |
| US20080260864A1 (en) * | 2005-10-21 | 2008-10-23 | Medidermis Ltd. | Topical Compositions for the Treatment of Depilation-Induced Irritation or Prevention Thereof |
| US20070248563A1 (en) * | 2006-04-19 | 2007-10-25 | Iovanni Carl F | Skin care compositions including marine extracts |
| ATE550011T1 (de) * | 2010-03-26 | 2012-04-15 | Procter & Gamble | Verfahren zur depilation und depilierausrüstung |
| GB201009275D0 (en) * | 2010-06-03 | 2010-07-21 | Reckitt & Colman Overseas | Improvements in or relating to compositions |
-
2011
- 2011-11-14 GB GB201119601A patent/GB2496447B/en not_active Expired - Fee Related
-
2012
- 2012-11-13 MX MX2014005849A patent/MX2014005849A/es unknown
- 2012-11-13 CN CN201280056065.7A patent/CN103998014A/zh active Pending
- 2012-11-13 US US14/357,782 patent/US20140309308A1/en not_active Abandoned
- 2012-11-13 AU AU2012338550A patent/AU2012338550B2/en not_active Ceased
- 2012-11-13 EP EP12791841.5A patent/EP2779986A2/en not_active Withdrawn
- 2012-11-13 RU RU2014124197/15A patent/RU2602187C2/ru active
- 2012-11-13 BR BR112014011460A patent/BR112014011460A2/pt not_active Application Discontinuation
- 2012-11-13 WO PCT/GB2012/052814 patent/WO2013072674A2/en active Application Filing
-
2014
- 2014-05-12 ZA ZA2014/03398A patent/ZA201403398B/en unknown
- 2014-06-10 IN IN4291CHN2014 patent/IN2014CN04291A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998044898A1 (en) * | 1997-04-09 | 1998-10-15 | Reckitt & Colman France | Depilatory compositions, their preparation and use |
| GB2367749A (en) * | 1997-07-09 | 2002-04-17 | Reckitt Benckiser France | Depilatory compositions |
| CN1809336A (zh) * | 2003-05-02 | 2006-07-26 | 荷兰联合利华有限公司 | 用于减少皮肤脱毛组合物刺激性的方法和试剂盒 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116904275A (zh) * | 2023-06-30 | 2023-10-20 | 广州市爱家有方日用品有限公司 | 一种生物酶催化分解管道疏通剂及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2496447B (en) | 2015-04-22 |
| WO2013072674A2 (en) | 2013-05-23 |
| EP2779986A2 (en) | 2014-09-24 |
| US20140309308A1 (en) | 2014-10-16 |
| MX2014005849A (es) | 2014-08-21 |
| GB2496447A (en) | 2013-05-15 |
| IN2014CN04291A (zh) | 2015-09-04 |
| AU2012338550A1 (en) | 2014-06-05 |
| BR112014011460A2 (pt) | 2017-05-09 |
| WO2013072674A3 (en) | 2013-12-27 |
| RU2602187C2 (ru) | 2016-11-10 |
| RU2014124197A (ru) | 2015-12-27 |
| AU2012338550B2 (en) | 2017-07-20 |
| ZA201403398B (en) | 2016-08-31 |
| GB201119601D0 (en) | 2011-12-28 |
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