CN103990228A - Multi-electrode bispectrum radio frequency tumor thermotherapy instrument capable of focusing electromagnetic field - Google Patents
Multi-electrode bispectrum radio frequency tumor thermotherapy instrument capable of focusing electromagnetic field Download PDFInfo
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- CN103990228A CN103990228A CN201410205883.XA CN201410205883A CN103990228A CN 103990228 A CN103990228 A CN 103990228A CN 201410205883 A CN201410205883 A CN 201410205883A CN 103990228 A CN103990228 A CN 103990228A
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Abstract
The invention discloses a multi-electrode bispectrum radio frequency tumor thermotherapy instrument capable of focusing an electromagnetic field, and belongs to medical apparatuses and instruments for tumor therapy. The multi-electrode bispectrum radio frequency tumor thermotherapy instrument comprises a radio frequency electrode, a dual-radio-frequency source, two power amplifiers, a control cabinet, a power source, a computer and a therapy bed. The radio frequency electrode is respectively connected with the power amplifiers through a diverter switch. The power amplifiers are respectively connected with the dual-radio-frequency source through two matchers. The dual-radio-frequency source is connected with the control cabinet. The control cabinet is respectively connected with the power source, the computer and the therapy bed. The multi-electrode bispectrum radio frequency tumor thermotherapy instrument is characterized in that the number of electrode bodies of a radio frequency electrode circumferential array is an odd number from 5 to 37, noncentral tumor focusing therapy is facilitated due to the design, tumor target tissue can be selectively and rapidly heated by means of the action of the electromagnetic field applied to the radio frequency electrode array, the tumor heating efficiency is improved, a tumor nutrition blood bed inside the body of a patient can be effectively damaged, and the problem that normal tissue is damaged by large-area wave field irradiation inside the tumor tissue can be avoided.
Description
Technical field:
The invention belongs to tumor medical apparatus and instruments, be specifically related to a kind of multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus that can focused electromagnetic.
Background technology:
Operative treatment tumor is acknowledged as one of optimal treatment method, secondly for suppressing, has x-ray radiotherapy machine, gamma-radiation cutter, laser scalpel etc. with the therapeutic device of direct killing tumor cell.But for some late periods and the poor patient who is not suitable for carrying out operative treatment of physical qualification just taking other Therapeutic Method, as methods such as radiotherapy, chemotherapy, thermotherapy, freezing, ethanol thromboembolisms, wherein thermotherapy is another the important tumor therapeuticing method after radiotherapy, chemotherapy, be a kind of to human body without any infringement green Therapeutic Method.According to tumor, form the characteristic of mechanism and tumor cell, will be automatically dead when tumor cell is subject to higher than body temperature certain value, people have invented the various instruments that heat to treat tumor for this reason, the medical market thermal therapeutic apparatus of popularization and application kinds of tumors, as microwave principle, radio frequency principle, the thermal therapeutic apparatus of ultrasonic wave principle etc., these thermal therapeutic apparatus utilize human body at microwave, capacitance field, more under the energy of sound wave, in human body, produce ion vibration and heat-dissipating, and make unique organizational structure of in-vivo tumour produce hot-spot, and then cause tumor tissues because of overheated and downright bad result, thereby reach the object for the treatment of tumor.
Medical research shows, not only heats is good to adopt the thermal therapeutic apparatus of radiothermics, and penetration power is strong, is a kind of comparatively desirable tumor-treatment instrument.Radio-frequency (RF) heat therapy equipment is a kind of intelligent tumor thermotherapy instrument that radiofrequency signal is converted into heat energy, mainly by the certain unipolar radio-frequency signal generator of frequency, produce, the radiofrequency signal of transmitting higher-wattage produces a high-frequency alternating magnetic field, tissue around electrode will be subject to electromagnetic field effects and change, the ion of tissue (comprising tumor tissues) and polar molecule twist at elect magnetic field generation molecule, friction, produce heat, tissue temperature is raise, in tumor heating process, normal structure blood flow is abundant, smooth and easy, the heat absorbing can be carried away to whole body through blood circulation, without heat storage benefit, and tumor tissues thrombosis cannot be taken away heat smoothly, produce heat retention, make the projecting normal structure 3-7 ℃ of its temperature, therefore, radio-frequency (RF) thermotherapeutic is to utilize the blood circulation difference of normal structure and tumor tissues to strengthen the destruction to cancerous cell.
But radio-frequency therapeutic equipment still comes with some shortcomings, as caused overheated pain because of cooling difficulty, its therapeutic process still difficulty reaches tumor tissues and kills and wounds effect, and therapeutic effect has much room for improvement.And because thermal therapeutic apparatus electrode mode of operation is fixed, employing comprises large area " wave field " irradiation of tumor tissues, can cause normal structure impaired, again because of energy out-focus, cause therapeutic efficiency low, be difficult to destroy the tumors of nutrients blood bed in body completely, thoroughly kill tumor tissues, its curative effect is also difficult to meet the requirement when pre-neoplastic medical field.
Summary of the invention:
The object of this invention is to provide a kind of multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus that efficiently can focused electromagnetic, the number of electrodes of its radio-frequency electrode circumferential array is the odd number between 5-37, be convenient to the focusing therapy of non-central tumor, can effectively destroy tumors of nutrients blood bed in patient body, thoroughly kill tumor tissues, its curative effect is remarkable, and the large area " wave field " that can avoid comprising tumor tissues is irradiated and caused the impaired problem of normal structure.
The object of the invention is to be achieved through the following technical solutions:
This can focused electromagnetic multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus, comprise radio-frequency electrode, Double RF source, amplifirer, switch board, power supply, computer and therapeutic bed, radio-frequency electrode connects respectively two amplifirers by change-over switch, two amplifirers connect Double RF source by two adapters respectively, Double RF source connects switch board, switch board is connected with power supply, computer and therapeutic bed respectively, described radio-frequency electrode consists of the electrode of circumferential array, and the number of electrodes on every circle is the odd number between 5-37.
During work, according to the position of tumor, determine selected electrode pair, so-called electrode pair is that line is carried out in the relative corresponding summit of face of the electrode of two diverse locations in radio-frequency electrode, between its line and two electrodes, must form a cylinder, and this cylinder region must can cover the tumor in non-central location, two electrodes like this could form electrode pair, thereby realize, the tumor in non-central location are carried out to focusing therapy.Every group of electrode pair can work successively in order or multi-group electrode to work in combination.In addition, thermal therapeutic apparatus of the present invention has bispectrum emission function, can select different frequency spectrum mode of operations according to the kind of tumor and feature, also can select staggered form mode of operation or combination type mode of operation.
The invention has the beneficial effects as follows: its radio-frequency electrode is arranged into superficial tumor specific region in the mode of circumferential array, the electrode of its circumferential array adds up to the odd number between 5-37, compared with prior art, the electrode pair with more bias, be convenient to carry out the focusing therapy of non-central tumor, wherein radio-frequency electrode can be the electrode of the above coaxial circumferential array of two circles, when radio-frequency electrode circumferential array is multi-turn electrode, according to the position of tumor or situation, can allow wherein one group of electrode carry out work, the electrode of its cocycle quits work, or multi-turn combination of electrodes work, when multi-turn combination of electrodes is worked, the electrode on same circle not can be made into electrode pair, can realize so three-dimensional focusing, effect can be better.The present invention be applicable to various just, in, the treatment of late tumor, by means of the effect that puts on the electromagnetic field on radio-frequency electrode array, realization is to the selective Fast Heating of in-vivo tumour destination organization, improve the tumor efficiency of heating surface, can effectively destroy tumors of nutrients blood bed in patient body, thoroughly kill tumor tissues, its curative effect is remarkable, and the large area " wave field " that can avoid comprising tumor tissues is irradiated and caused the impaired problem of normal structure.Its radio frequency electromagnetic field focus method is the electrode pair that select progressively electromagnetic field covers tumor, according to the kind of tumor and feature, selected electrode pair can sequential working or multi-group electrode to work in combination, increase along with radio-frequency electrode matrix number, take sequential working pattern can effectively reduce the heat effect that radio frequency electromagnetic field produces human epidermal, reduce the hot causalgia of patient bitter.In addition the present invention has bispectrum emission function, can select different frequency spectrum mode of operations according to the kind of tumor and feature, also can select staggered form mode of operation or combination type mode of operation.
Accompanying drawing explanation:
Fig. 1 is theory diagram of the present invention.
Fig. 2 is electrode focusing principle schematic diagram in embodiments of the invention one.
Fig. 3 is electrode focusing principle schematic diagram in embodiments of the invention two.
Fig. 4 is that in embodiments of the invention three, radio-frequency electrode circumferential array is the schematic diagram of the electrode of two circles.
Fig. 5 is half electrode focusing principle schematic diagram in embodiments of the invention three.
Fig. 6 is second half electrode focusing principle schematic diagram in embodiments of the invention three.
Fig. 7 is that in embodiments of the invention four, radio-frequency electrode circumferential array is the schematic diagram of the electrode of three circles
Fig. 8 is half electrode focusing principle schematic diagram that in embodiments of the invention four, the first electrode collar and third electrode circle carry out electrode pairing.
Fig. 9 is second half electrode focusing principle schematic diagram that in embodiments of the invention four, the first electrode collar and third electrode circle carry out electrode pairing.
Figure 10 is the electrode focusing principle schematic diagram on the second electrode collar in embodiments of the invention four.
The specific embodiment
Embodiment mono-
With reference to Fig. 1, multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus that can focused electromagnetic of the present invention, comprise radio-frequency electrode, Double RF source, amplifirer, switch board, power supply, computer and therapeutic bed, radio-frequency electrode connects respectively two amplifirers by change-over switch, two amplifirers connect respectively 100KHz low radio frequency source and 13.5MHz firing frequency source by two adapters respectively, 100KHz low radio frequency source is connected respectively switch board with 13.56MHz firing frequency source, switch board respectively with power supply, computer and therapeutic bed are connected, computer also connects power supply, two amplifirers connect respectively two data processors, two data processors connect respectively two controllers, described radio-frequency electrode consists of the electrode of circumferential array, with reference to Fig. 2, the present embodiment be take the electrode of radio-frequency electrode circumferential array as a circle, it is example that number of electrodes is 17, suppose knub position human body lie low cross section fourth quadrant a bit on, in Fig. 2, selected 1
1-1
9, 1
2-1
10, 1
3-1
10, 1
4-1
11, 1
5-1
12, 1
6-1
13, 1
7-1
14, 1
8-1
16totally 8 groups of electrode pairs, as can be seen from Figure 2, number of electrodes is odd number, suitable electrode pair is selected in position according to tumor in coordinate system, the cylinder region that selected each electrode pair forms is eccentric region, this eccentric region can cover the position at tumor place in fourth quadrant, is convenient to non-central tumor to carry out focusing therapy.During work, these 8 groups of electrode pairs can be worked in order successively, or multi-group electrode is to work in combination.
The electrode of the radio-frequency electrode circumferential array in the present embodiment also can be for more than two circles, when work, only select the wherein electrode of a circle to carry out work, the electrode of its cocycle quits work, and chooses the selected electrode pair of electrode on circle identical with 8 groups of electrode pairs selected in Fig. 2.
Embodiment bis-
With reference to Fig. 3, different from embodiment mono-, the present embodiment take electrode that radio-frequency electrode circumferential array is a circle, number of electrodes as 15 be example, suppose knub position human body lie low cross section first quartile a bit on, in Fig. 3, selected 1
1-1
8; 1
2-1
9; 1
3-1
10; 1
4-1
12; 1
5-1
13; 1
6-1
14; 1
7-1
15totally 7 groups of electrode pairs, as can be seen from Figure 3, number of electrodes is odd number, suitable electrode pair is selected in position according to tumor in coordinate system, the cylinder region that selected each electrode pair forms is eccentric region, this eccentric region can cover the position at tumor place in first quartile, is convenient to non-central tumor to carry out focusing therapy.During work, these 7 groups of electrode pairs can be worked in order successively, or multi-group electrode is to work in combination.
The electrode of the radio-frequency electrode circumferential array in the present embodiment also can be for more than two circles, when work, only select the wherein electrode of a circle to carry out work, the electrode of its cocycle quits work, and chooses the selected electrode pair of electrode on circle identical with 7 groups of electrode pairs selected in Fig. 3.
Embodiment tri-
With reference to Fig. 4, Fig. 5 and Fig. 6, different from embodiment mono-is, the present embodiment be take the electrode that radio-frequency electrode circumferential array is two circles, the number of electrodes on each circle and is 17 as example, during work, tumor is between first lap electrode 1 and the second circle electrode 2, and the position according to tumor in coordinate system, chooses the electrode formation electrode pair on first lap electrode 1 and the second circle electrode 2, suppose knub position human body lie low cross section first quartile a bit on, in Fig. 5 and Fig. 6, selected 1
1-2
9; 1
2-2
10; 1
3-2
10; 1
4-2
11; 1
5-2
12; 1
6-2
13; 1
7-2
14; 1
8-2
16; 2
1-1
9; 2
2-1
10; 2
3-1
10; 2
4-1
11; 2
5-1
12; 2
6-1
13; 2
7-1
14; 2
8-1
16totally 16 groups of electrode pairs, selected electrode pair is that the position in coordinate system is selected according to tumor, selected electrode pair is the electrode on same circle not, can realize so three-dimensional focusing, the cylinder region that each electrode pair forms is eccentric region, this eccentric region can cover the position at tumor place in fourth quadrant, is convenient to non-central tumor to carry out focusing therapy.During work, these 16 groups of electrode pairs can be worked in order successively, or multi-group electrode is to work in combination.
In the present embodiment, also can enable separately the first electrode collar 1 or second circle electrode 2 carry out work, as the working method of embodiment mono-or embodiment bis-.
Embodiment tetra-
With reference to Fig. 7, Fig. 8, Fig. 9 and Figure 10, different from embodiment mono-is, the present embodiment be take the electrode that radio-frequency electrode circumferential array is three circles, the number of electrodes on each circle and is 15 as example, during work, tumor is positioned at the second circle electrode 2, position according to tumor in coordinate system, the electrode of choosing on first lap electrode 1 and the 3rd circle electrode 3 forms electrode pair, simultaneously, electrode self on the second circle electrode 2 is also carrying out electrode pair pairing, suppose knub position human body lie low cross section first quartile a bit on, in Fig. 8, Fig. 9 and Figure 10, selected 1
1-3
8; 1
2-3
9; 1
3-3
10; 1
4-3
12; 1
5-3
13; 1
6-3
14; 1
7-3
15; 3
1-1
8; 3
2-1
9; 3
3-1
10; 3
4-1
12; 3
5-1
13; 3-1
14; 3
7-1
15; 2
1-2
8; 2
2-2
9; 2
3-2
10; 2
4-2
12; 2
5-2
13; 2-2
14; 2
7-2
15totally 21 groups of electrode pairs, selected electrode pair is that the position in coordinate system is selected according to tumor, the first electrode collar 1 of choosing and the 3rd circle electrode collar 3 top electrodes are to being the electrode on same circle not, can realize so three-dimensional focusing, electrode pair on the second electrode collar 2 of choosing continues tumor locus to carry out focusing therapy, the cylinder region that each electrode pair forms is eccentric region, this eccentric region can cover the position at tumor place in first quartile, is convenient to non-central tumor to carry out focusing therapy.These are mixed right electrode and can take turns to operate in order, also can work, or multi-group electrode are to work in combination simultaneously.
In the present embodiment, also can enable separately the first electrode collar 1, or second circle electrode 2, or the 3rd circle electrode carry out work, as the working method of embodiment mono-or embodiment bis-; Or choose arbitrarily two circle electrodes and carry out work, as the working method of embodiment tri-.
In each embodiment, the number of electrodes on every circle can also be other odd number between 5-37 above, and wherein 11,13,15,17,19,21 is preferred number, and its operation principle is identical with each embodiment.
In addition, the frequency in the Double RF source in the present invention can be adjusted to other suitable frequency values according to the practical situation of tumor, is not limited to the frequency values that embodiment provides.
Claims (8)
- One kind can focused electromagnetic multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus, it comprises radio-frequency electrode, Double RF source, amplifirer, switch board, power supply, computer and therapeutic bed, radio-frequency electrode connects respectively two amplifirers by change-over switch, two amplifirers connect Double RF source by two adapters respectively, Double RF source connects switch board, switch board is connected with power supply, computer and therapeutic bed respectively, it is characterized in that: described radio-frequency electrode consists of the electrode of circumferential array, the number of electrodes on every circle is the odd number between 5-37.
- 2. multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus that can focused electromagnetic as claimed in claim 1, is characterized in that: the odd number that the number of electrodes on every circle is 11-21.
- 3. multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus that can focused electromagnetic as claimed in claim 1, is characterized in that: radio-frequency electrode is the electrodes of the above coaxial circumferential array of two circles.
- 4. multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus that can focused electromagnetic as claimed in claim 3, is characterized in that: between the electrode on same circle, can not match.
- 5. multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus that can focused electromagnetic as claimed in claim 3, is characterized in that: radio-frequency electrode is the electrode of the coaxial circumferential array of 2 to 5 circle.
- 6. multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus that can focused electromagnetic as claimed in claim 4, is characterized in that: the electrode number in every circle radio-frequency electrode is identical.
- 7. multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus that can focused electromagnetic as claimed in claim 6, is characterized in that: the odd number that the electrode number on every circle electrode is 11-21.
- As described in any one of claim 1-7 can focused electromagnetic multi-electrode bispectrum radio frequency tumour thermal therapeutic apparatus, it is characterized in that: described Double RF source is respectively 100KHz and 13.56MHz.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107320105A (en) * | 2017-07-24 | 2017-11-07 | 北京大学 | The Magnetic resonance imaging and electromagnetic induction and RF therapy system of a kind of combination |
| CN110461262A (en) * | 2017-04-10 | 2019-11-15 | 圣犹达医疗用品心脏病学部门有限公司 | The method of electric perforating system and excitation conduit |
| CN111939479A (en) * | 2020-08-20 | 2020-11-17 | 哈尔滨乔然科技有限公司 | Phased array thermotherapy machine and control method thereof |
| CN114304753A (en) * | 2022-02-24 | 2022-04-12 | 湖北中烟工业有限责任公司 | Multi-polar-point radio frequency heating smoking set |
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| WO2003002199A2 (en) * | 2001-06-26 | 2003-01-09 | Siemens Aktiengesellschaft | Magnetic resonance system and method for operating the same |
| CN102210907A (en) * | 2010-04-06 | 2011-10-12 | Bsd医药公司 | Deep heating hyperthermia using phased arrays and patient positioning |
| CN103200894A (en) * | 2010-09-06 | 2013-07-10 | It`Is基金会 | Electromagnetic field applicator array with integral field sensors for implicit correction of mutual coupling and mismatch |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2003002199A2 (en) * | 2001-06-26 | 2003-01-09 | Siemens Aktiengesellschaft | Magnetic resonance system and method for operating the same |
| CN102210907A (en) * | 2010-04-06 | 2011-10-12 | Bsd医药公司 | Deep heating hyperthermia using phased arrays and patient positioning |
| CN103200894A (en) * | 2010-09-06 | 2013-07-10 | It`Is基金会 | Electromagnetic field applicator array with integral field sensors for implicit correction of mutual coupling and mismatch |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110461262A (en) * | 2017-04-10 | 2019-11-15 | 圣犹达医疗用品心脏病学部门有限公司 | The method of electric perforating system and excitation conduit |
| CN110461262B (en) * | 2017-04-10 | 2023-01-06 | 圣犹达医疗用品心脏病学部门有限公司 | Electroporation system and method of exciting catheter |
| CN107320105A (en) * | 2017-07-24 | 2017-11-07 | 北京大学 | The Magnetic resonance imaging and electromagnetic induction and RF therapy system of a kind of combination |
| CN107320105B (en) * | 2017-07-24 | 2023-11-28 | 北京大学 | Combined nuclear magnetic resonance imaging and electromagnetic induction and radio frequency treatment system |
| CN111939479A (en) * | 2020-08-20 | 2020-11-17 | 哈尔滨乔然科技有限公司 | Phased array thermotherapy machine and control method thereof |
| CN114304753A (en) * | 2022-02-24 | 2022-04-12 | 湖北中烟工业有限责任公司 | Multi-polar-point radio frequency heating smoking set |
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