CN103990187A - Coronary stent with anti-coagulation and vascular endothelial cell adhesion acceleration effects and preparation method thereof - Google Patents
Coronary stent with anti-coagulation and vascular endothelial cell adhesion acceleration effects and preparation method thereof Download PDFInfo
- Publication number
- CN103990187A CN103990187A CN201410252832.2A CN201410252832A CN103990187A CN 103990187 A CN103990187 A CN 103990187A CN 201410252832 A CN201410252832 A CN 201410252832A CN 103990187 A CN103990187 A CN 103990187A
- Authority
- CN
- China
- Prior art keywords
- support
- concentration
- distilled water
- solution
- stent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a coronary stent with anti-coagulation and vascular endothelial cell adhesion acceleration effects and a preparation method thereof. The method comprises the following steps: soaking the stent into a dopamine and lysine solution to bath; soaking in an N-(3-aminopropyl) methylacrylate solution to carry out pre-treatment, and then dissolving the processed stent into a 2-methacryloyloxyethyl phosphorylcholine solution; adding tetramethylethylenediamine, N,N-methylene diacrylamine and ammonium persulfate to the solution to react; soaking into an arginine-glycine-aspartic acid (RGD) peptide solution, adding tetramethylethylenediamine (TEMED) and ammonium persulfate (APS) to react, so as to prepare a coating. Protein adsorption, denaturation of adsorption protein and platelet adhesiveness can be reduced and inhibited by a 2-methacryloyloxyethyl phosphorylcholine (MPC) part contained in the coating of the coronary stent, inflammatory response is inhibited, adhesion to the stent caused by vascular endothelial cells can be accelerated by the contained RGD part, the coronary stent has good biocompatibility, the stent better exists inside a body to play the function, and the coronary stent has good application prospect in the aspect of cardiovascular and cerebrovascular diseases.
Description
Technical field
The invention discloses a kind of coronary stent and preparation method that there is anticoagulation and promote vascular endothelial cell adhesive attraction.
Background technology
Coronary stent self-application since clinical, has developed very soon, and application is more and more, has become the Main Means of myocardial blood transport reconstruction at present.At the Cardiac Catheterization Room of many hospitals, in percutaneous coronary intervention (pci), 80% case is implanted coronary stent.Former because: after (1) implant frame, the image of radiography is very good, acute stage result good; (2) because support can be treated caused by balloon expandable acute or be on the verge of obturation, the safety of interventional therapy is obviously improved; (3) support can reduce restenosis rate, improves patient's long-term prognosis; (4) implant frame easily operates; (5) application of support can reduce the operating time; (6) for complex lesions, balloon expandable result is often undesirable, and implant frame can obtain satisfied result.These are applied widely and give the credit to perfect, the deep understanding to implant frame vascular damaged of support technology and the progress of ancillary drug treatment.
The support using clinically is now metal rack, has some defects, is mainly the in-stent restenosis that thrombosis and neointimal hyperplasia cause.
The interaction that MPC and blood constituent are shown in is little, can reduce degeneration and the PA of protein adsorption, restrain adsorption albumen, and inflammation-inhibiting reaction has good blood and histocompatibility simultaneously, has good blood coagulation resisting function.
RGD part can promote the adhesion of vascular endothelial cell to support, and has good biocompatibility, makes support better be present in its function of performance in body.
Meanwhile, the support that coating is good needed to carry out degerming except thermal source before being applied to actual clinical.At present the normal method using is to use the sterilizing that carries out disinfection of high temperature or disinfectant solution, but these methods are all easy to destroy coating.
Summary of the invention
The object of the invention is to prepare a kind of coronary stent and preparation method that there is anticoagulation and promote vascular endothelial cell adhesive attraction, thereby reduce the existing defect of support using clinically now.
Technical scheme of the present invention is as follows:
The coronary stent that anticoagulation and promotion vascular endothelial cell adhere to is provided with 2-methylacryoyloxyethyl Phosphorylcholine (MPC) gel coat on support.
The coronary stent that anticoagulation and promotion vascular endothelial cell adhere to is connected to rgd peptide on the gel coat of support.
The preparation method of coronary stent of the present invention, step is as follows:
1) get ordinary stent and use successively organic solvent, deionized water supersound process; After taking-up, support is dried up by nitrogen current;
2) get dopamine hydrochloride and lysine, the dopamine solution that adds the buffer of pH=6～9 to be configured to, concentration is 1～100mg/mL; By step 1) support after treatment is immersed in above-mentioned solution, is positioned over 1～10h in 20～100 DEG C of water-baths; With distilled water cleaning, take out support and dried up by nitrogen current;
3) prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water, concentration is 10～400mg/mL, support is soaked wherein to fully reaction, take out after completion of the reaction support distilled water and repeatedly rinse, dried up by nitrogen current;
4) in centrifuge tube, dissolve MPC with distilled water and make solution, concentration is 10～400mg/mL; Add concentration to be BIS and the TEMED of 10～400mg/mL, mix, support is put into wherein, adding concentration is 10～400mg/mL initiator A PS; Take out after completion of the reaction support distilled water rinsing;
5) with distilled water preparation RGD solution, concentration is 10～400mg/mL, support is soaked wherein, add concentration to be BIS and the TEMED of 10～400mg/mL to the inside, fully mix, then to add concentration be 10～400mg/mL initiator A PS, take out after completion of the reaction support distilled water rinsing, rack surface is dried up with clean nitrogen, complete coating;
6) adopt 10KGy～80KGy's
60co gamma-rays carries out step 5) support irradiation sterilization.
Described organic solvent is methanol, ethanol, propanol, acetone, ethyl acetate, chloroform, DMF, dimethyl sulfoxide or dichloromethane.
Described initiator is organic peroxide evocating agent, inorganic peroxide initiator, azo-initiator or redox initiator.
Described MPC or RGD concentration are preferably at 100～200mg/mL.
Described
60preferably 30KGy～50KGy of Co gamma-ray irradiation dosage.
Described ordinary stent is stainless steel stent, nick-eltitanium alloy stent, cochrome support, magnesium alloy bracket or platinum alloy support.
The key of this preparation method is the concentration of MPC, RGD, and concentration is too low or too high is all not easy to form gel.When the concentration of MPC, RGD is within the scope of 10～400mg/mL, can form the good gel of homogeneous transparent, elasticity and hardness.Especially better effects if in the scope of 100～200mg/mL.
Concentration as for dopamine solution, APM, BIS, APS, TEMED also can produce certain impact to gel quality affects, and dopamine solution concentration is at 1～100mg/mL, and APM, BIS, APS, TEMED concentration can form gel within the scope of 10～400mg/mL.Especially in dopamine solution concentration at 5～10mg/mL, APM, BIS, APS, TEMED concentration better effects if within the scope of 100～200mg/mL.
The present invention adopts
60the mode of Co gamma-ray irradiation is carried out the operation of degerming depyrogenation.
The invention discloses a kind of coronary stent and preparation method that there is anticoagulation and promote vascular endothelial cell adhesive attraction.Support is immersed in to water-bath in dopamine and lysine solution, then takes out and dry up by nitrogen current.Be immersed in again pretreatment in N-(3-aminopropyl) methacrylate (APM) solution, then with clean nitrogen, rack surface dried up.Then the support of processing is dissolved in 2-methylacryoyloxyethyl Phosphorylcholine (MPC) solution, in solution, add tetramethylethylenediamine (TEMED), N, N-methylene diacrylamine (BIS) and Ammonium persulfate. (APS) reaction; Reaction finishes rear taking-up support, is immersed in rgd peptide solution, adds TEMED and APS to the inside, and reaction prepares coating; Then take out support, after drying up with clean nitrogen, complete coating.The coating of support is the external rgd peptide of 2-methylacryoyloxyethyl Phosphorylcholine.The 2-methylacryoyloxyethyl Phosphorylcholine part containing in the coating of this coronary stent can reduce degeneration and the PA of protein adsorption, restrain adsorption albumen, and inflammation-inhibiting reaction has good blood and histocompatibility simultaneously; The RGD part containing in coating can promote the adhesion of vascular endothelial cell to support, and has good biocompatibility, makes support better be present in its function of performance in body, aspect cardiovascular and cerebrovascular disease, has a good application prospect.
Detailed description of the invention
Below by example, the present invention will be further elaborated.
Embodiment mono-:
1. get stainless steel stent and use successively acetone, deionized water supersound process, takes out, and support is dried up by nitrogen current;
2. get dopamine hydrochloride and lysine, the dopamine solution that adds the buffer of pH=6 to be configured to, concentration is 1～5mg/mL.Support is immersed in above-mentioned solution, is positioned over 1h in 20 DEG C of water-baths.After completion of the reaction support is taken out, with distilled water cleaning, be then immersed in soaking and washing in distilled water.Taking out support is dried up by nitrogen current;
3. prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water, concentration is 10mg/mL, and support is soaked wherein to fully reaction, takes out after completion of the reaction support distilled water and repeatedly rinses, and is dried up by nitrogen current;
4. in centrifuge tube, dissolve MPC with distilled water and make solution, concentration is 10mg/mL, adds BIS, TEMED to the inside, and concentration is 10mg/mL, fully mixes, and support is put into wherein, adds APS, and concentration is 10mg/mL.Take out after completion of the reaction support distilled water rinsing, for subsequent use;
5. with distilled water preparation RGD solution, concentration is 10mg/mL, and support is soaked wherein, adds BIS, TEMED to the inside, and concentration is 10mg/mL, fully mixes, and adds APS, and concentration is 10mg/mL.Take out after completion of the reaction support distilled water rinsing, rack surface is dried up with clean nitrogen, complete coating;
6. adopt 10～30KGy's
60co gamma-rays carries out irradiation sterilization.
Embodiment bis-:
1. get magnesium alloy bracket and use successively methanol, deionized water supersound process, takes out, and support is dried up by nitrogen current;
2. get dopamine hydrochloride and lysine, the dopamine solution that adds the buffer of pH=8 to be configured to, concentration is 5～10mg/mL.Support is immersed in above-mentioned solution, is positioned over 6h in 60 DEG C of water-baths.After completion of the reaction support is taken out, with distilled water cleaning, be then immersed in soaking and washing in distilled water.Taking out support is dried up by nitrogen current;
3. prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water, concentration is 150mg/mL, and support is soaked wherein to fully reaction, takes out after completion of the reaction support distilled water and repeatedly rinses, and is dried up by nitrogen current;
4. in centrifuge tube, dissolve MPC with distilled water and make solution, concentration is 150mg/mL, adds BIS, TEMED to the inside, and concentration is 150mg/mL, fully mixes, and support is put into wherein, adds APS, and concentration is 150mg/mL.Take out after completion of the reaction support distilled water rinsing, for subsequent use;
5. with distilled water preparation RGD solution, concentration is 150mg/mL, and support is soaked wherein, adds BIS, TEMED to the inside, and concentration is 150mg/mL, fully mixes, and adds APS, and concentration is 150mg/mL.Take out after completion of the reaction support distilled water rinsing, rack surface is dried up with clean nitrogen, complete coating;
6. adopt 30～50KGy's
60co gamma-rays carries out irradiation sterilization.
Embodiment tri-:
1. get platinum alloy support and use successively propanol, deionized water supersound process, takes out, and support is dried up by nitrogen current;
2. get dopamine hydrochloride and lysine, the dopamine solution that adds the buffer of pH=9 to be configured to, concentration is 90～100mg/mL.Support is immersed in above-mentioned solution, is positioned over 10h in 100 DEG C of water-baths.After completion of the reaction support is taken out, with distilled water cleaning, be then immersed in soaking and washing in distilled water.Taking out support is dried up by nitrogen current;
3. prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water, concentration is 400mg/mL, and support is soaked wherein to fully reaction, takes out after completion of the reaction support distilled water and repeatedly rinses, and is dried up by nitrogen current;
4. in centrifuge tube, dissolve MPC with distilled water and make solution, concentration is 400mg/mL, adds BIS, TEMED to the inside, and concentration is 400mg/mL, fully mixes, and support is put into wherein, adds APS, and concentration is 400mg/mL.Take out after completion of the reaction support distilled water rinsing, for subsequent use;
5. with distilled water preparation RGD solution, concentration is 400mg/mL, and support is soaked wherein, adds BIS, TEMED to the inside, and concentration is 400mg/mL, fully mixes, and adds APS, and concentration is 400mg/mL.Take out after completion of the reaction support distilled water rinsing, rack surface is dried up with clean nitrogen, complete coating;
6. adopt 50～80KGy's
60co gamma-rays carries out irradiation sterilization.
Embodiment tetra-:
1. get nick-eltitanium alloy stent and use successively chloroform, deionized water supersound process, takes out, and support is dried up by nitrogen current;
2. get dopamine hydrochloride and lysine, the dopamine solution that adds the buffer of pH=9 to be configured to, concentration is 10～20mg/mL.Support is immersed in above-mentioned solution, is positioned over 10h in 100 DEG C of water-baths.After completion of the reaction support is taken out, with distilled water cleaning, be then immersed in soaking and washing in distilled water.Taking out support is dried up by nitrogen current;
3. prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water, concentration is 200mg/mL, and support is soaked wherein to fully reaction, takes out after completion of the reaction support distilled water and repeatedly rinses, and is dried up by nitrogen current;
4. in centrifuge tube, dissolve MPC with distilled water and make solution, concentration is 300mg/mL, adds BIS, TEMED to the inside, and concentration is 200mg/mL, fully mixes, and support is put into wherein, adds APS, and concentration is 200mg/mL.Take out after completion of the reaction support distilled water rinsing, for subsequent use;
5. with distilled water preparation RGD solution, concentration is 200mg/mL, and support is soaked wherein, adds BIS, TEMED to the inside, and concentration is 300mg/mL, fully mixes, and adds APS, and concentration is 200mg/mL.Take out after completion of the reaction support distilled water rinsing, rack surface is dried up with clean nitrogen, complete coating;
6. adopt 30～50KGy's
60co gamma-rays carries out irradiation sterilization.
Embodiment five:
1. get cochrome support and use successively ethanol, deionized water supersound process, takes out, and support is dried up by nitrogen current;
2. get dopamine hydrochloride and lysine, the dopamine solution that adds the buffer of pH=7 to be configured to, concentration is 10～20mg/mL.Support is immersed in above-mentioned solution, is positioned over 5h in 70 DEG C of water-baths.After completion of the reaction support is taken out, with distilled water cleaning, be then immersed in soaking and washing in distilled water.Taking out support is dried up by nitrogen current;
3. prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water, concentration is 150mg/mL, and support is soaked wherein to fully reaction, takes out after completion of the reaction support distilled water and repeatedly rinses, and is dried up by nitrogen current;
4. in centrifuge tube, dissolve MPC with distilled water and make solution, concentration is 150mg/mL, adds BIS, TEMED to the inside, and concentration is 300mg/mL, fully mixes, and support is put into wherein, adds APS, and concentration is 300mg/mL.Take out after completion of the reaction support distilled water rinsing, for subsequent use;
5. with distilled water preparation RGD solution, concentration is 150mg/mL, and support is soaked wherein, adds BIS, TEMED to the inside, and concentration is 300mg/mL, fully mixes, and adds APS, and concentration is 300mg/mL.Take out after completion of the reaction support distilled water rinsing, rack surface is dried up with clean nitrogen, complete coating;
6. adopt 10～30KGy's
60co gamma-rays carries out irradiation sterilization.
Embodiment six:
1. get stainless steel alloy support and use successively dichloromethane, deionized water supersound process, takes out, and support is dried up by nitrogen current;
2. get dopamine hydrochloride and lysine, the dopamine solution that adds the buffer of pH=9 to be configured to, concentration is 1～10mg/mL.Support is immersed in above-mentioned solution, is positioned over 5h in 20 DEG C of water-baths.After completion of the reaction support is taken out, with distilled water cleaning, be then immersed in soaking and washing in distilled water.Taking out support is dried up by nitrogen current;
3. prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water, concentration is 150mg/mL, and support is soaked wherein to fully reaction, takes out after completion of the reaction support distilled water and repeatedly rinses, and is dried up by nitrogen current;
4. in centrifuge tube, dissolve MPC with distilled water and make solution, concentration is 150mg/mL, adds BIS, TEMED to the inside, and concentration is 300mg/mL, fully mixes, and support is put into wherein, adds APS, and concentration is 300mg/mL.Take out after completion of the reaction support distilled water rinsing, for subsequent use;
5. with distilled water preparation RGD solution, concentration is 150mg/mL, and support is soaked wherein, adds BIS, TEMED to the inside, and concentration is 300mg/mL, fully mixes, and adds APS, and concentration is 300mg/mL.Take out after completion of the reaction support distilled water rinsing, rack surface is dried up with clean nitrogen, complete coating;
6. adopt 30～50KGy's
60co gamma-rays carries out irradiation sterilization.
Embodiment seven:
1. get cochrome support and use successively ethyl acetate, deionized water supersound process, takes out, and support is dried up by nitrogen current;
2. get dopamine hydrochloride and lysine, the dopamine solution that adds the buffer of pH=6 to be configured to, concentration is 10～100mg/mL.Support is immersed in above-mentioned solution, is positioned over 3h in 50 DEG C of water-baths.After completion of the reaction support is taken out, with distilled water cleaning, be then immersed in soaking and washing in distilled water.Taking out support is dried up by nitrogen current;
3. prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water, concentration is 150mg/mL, and support is soaked wherein to fully reaction, takes out after completion of the reaction support distilled water and repeatedly rinses, and is dried up by nitrogen current;
4. in centrifuge tube, dissolve MPC with distilled water and make solution, concentration is 300mg/mL, adds BIS, TEMED to the inside, and concentration is 300mg/mL, fully mixes, and support is put into wherein, adds APS, and concentration is 300mg/mL.Take out after completion of the reaction support distilled water rinsing, for subsequent use;
5. with distilled water preparation RGD solution, concentration is 300mg/mL, and support is soaked wherein, adds BIS, TEMED to the inside, and concentration is 300mg/mL, fully mixes, and adds APS, and concentration is 300mg/mL.Take out after completion of the reaction support distilled water rinsing, rack surface is dried up with clean nitrogen, complete coating;
6. adopt 50～80KGy's
60co gamma-rays carries out irradiation sterilization.
Claims (8)
1. a coronary stent for anticoagulation and promotion vascular endothelial cell adhesive attraction, is characterized in that being provided with MPC gel coat on support.
2. support as claimed in claim 2, is characterized in that being connected to rgd peptide on described support gel coat.
3. the preparation method of the coronary stent of claim 1 or 2, is characterized in that it being that step is as follows:
1) get ordinary stent and use successively organic solvent, deionized water supersound process; After taking-up, support is dried up by nitrogen current;
2) get dopamine hydrochloride and lysine, the dopamine solution that adds the buffer of pH=6～9 to be configured to, concentration is 1～100mg/mL; By step 1) support after treatment is immersed in above-mentioned solution, is positioned over 1～10h in 20～100 DEG C of water-baths; With distilled water cleaning, take out support and dried up by nitrogen current;
3) prepare N-(3-aminopropyl) methacrylate (APM) solution with distilled water, concentration is 10～400mg/mL, support is soaked wherein to fully reaction, take out after completion of the reaction support distilled water and repeatedly rinse, dried up by nitrogen current;
4) in centrifuge tube, dissolve MPC with distilled water and make solution, concentration is 10～400mg/mL; Add concentration to be BIS and the TEMED of 10～400mg/mL, mix, support is put into wherein, adding concentration is 10～400mg/mL initiator A PS; Take out after completion of the reaction support distilled water rinsing;
5) with distilled water preparation RGD solution, concentration is 10～400mg/mL, support is soaked wherein, add concentration to be BIS and the TEMED of 10～400mg/mL to the inside, fully mix, then to add concentration be 10～400mg/mLAPS, take out after completion of the reaction support distilled water rinsing, rack surface is dried up with clean nitrogen, complete coating;
6) adopt 10KGy～80KGy's
60co gamma-rays carries out step 5) support irradiation sterilization.
4. method as claimed in claim 3, is characterized in that described organic solvent is methanol, ethanol, propanol, acetone, ethyl acetate, chloroform, DMF, dimethyl sulfoxide or dichloromethane.
5. method as claimed in claim 3, is characterized in that described initiator is organic peroxide evocating agent, inorganic peroxide initiator, azo-initiator or redox initiator.
6. method as claimed in claim 3, is characterized in that described MPC or RGD concentration are at 100～200mg/mL.
7. method as claimed in claim 3, described in it is characterized in that
60co gamma-ray irradiation dosage is 30KGy～50KGy.
8. method as claimed in claim 3, is characterized in that described ordinary stent is stainless steel stent, nick-eltitanium alloy stent, cochrome support, magnesium alloy bracket or platinum alloy support.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410252832.2A CN103990187A (en) | 2014-06-09 | 2014-06-09 | Coronary stent with anti-coagulation and vascular endothelial cell adhesion acceleration effects and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410252832.2A CN103990187A (en) | 2014-06-09 | 2014-06-09 | Coronary stent with anti-coagulation and vascular endothelial cell adhesion acceleration effects and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103990187A true CN103990187A (en) | 2014-08-20 |
Family
ID=51304681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410252832.2A Pending CN103990187A (en) | 2014-06-09 | 2014-06-09 | Coronary stent with anti-coagulation and vascular endothelial cell adhesion acceleration effects and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103990187A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308507A (en) * | 2017-07-06 | 2017-11-03 | 苏州医甸园医疗科技发展有限公司 | A kind of intravascular stent based on sea-mussel mucin coating and preparation method thereof |
| CN111298202A (en) * | 2020-03-04 | 2020-06-19 | 四川大学 | Long-acting anticoagulant antibacterial coating for extracorporeal membrane oxygenation device (ECMO) and preparation method thereof |
| CN112316218A (en) * | 2020-10-26 | 2021-02-05 | 西北大学 | Zwitterionic polymer and heparin composite coating, preparation method and application thereof |
| CN114904060A (en) * | 2022-05-30 | 2022-08-16 | 浙江大学 | Medical catheter containing anti-adhesion layer and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090324672A1 (en) * | 2008-06-30 | 2009-12-31 | Florencia Lim | Poly(Ester-Amide) And Poly(Amide) Coatings For Implantable Medical Devices For Controlled Release Of A Protein Or Peptide And A Hydrophobic Drug |
| CN102091355A (en) * | 2011-01-11 | 2011-06-15 | 南京大学 | Compound coating coronary medicament eluting stent and preparation method thereof |
| CN102274553A (en) * | 2011-05-16 | 2011-12-14 | 天津大学 | Coronary artery bracket with anticoagulant action and preparation method thereof |
-
2014
- 2014-06-09 CN CN201410252832.2A patent/CN103990187A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090324672A1 (en) * | 2008-06-30 | 2009-12-31 | Florencia Lim | Poly(Ester-Amide) And Poly(Amide) Coatings For Implantable Medical Devices For Controlled Release Of A Protein Or Peptide And A Hydrophobic Drug |
| CN102091355A (en) * | 2011-01-11 | 2011-06-15 | 南京大学 | Compound coating coronary medicament eluting stent and preparation method thereof |
| CN102274553A (en) * | 2011-05-16 | 2011-12-14 | 天津大学 | Coronary artery bracket with anticoagulant action and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 朱爱萍 等: "血管内支架的研究进展", 《生物医学工程学杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308507A (en) * | 2017-07-06 | 2017-11-03 | 苏州医甸园医疗科技发展有限公司 | A kind of intravascular stent based on sea-mussel mucin coating and preparation method thereof |
| CN111298202A (en) * | 2020-03-04 | 2020-06-19 | 四川大学 | Long-acting anticoagulant antibacterial coating for extracorporeal membrane oxygenation device (ECMO) and preparation method thereof |
| CN112316218A (en) * | 2020-10-26 | 2021-02-05 | 西北大学 | Zwitterionic polymer and heparin composite coating, preparation method and application thereof |
| CN114904060A (en) * | 2022-05-30 | 2022-08-16 | 浙江大学 | Medical catheter containing anti-adhesion layer and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103990187A (en) | Coronary stent with anti-coagulation and vascular endothelial cell adhesion acceleration effects and preparation method thereof | |
| CN101549170B (en) | Human body absorbable blood vessel support and its manufacturing method | |
| CN104857570B (en) | A kind of degradable zinc-containing alloy support and preparation method thereof | |
| CN106102785A (en) | Implantable medical device | |
| CN103691007B (en) | Manufacturing method of temperature-sensitive hydrogel compound coating intravascular stent | |
| CN104888282B (en) | A kind of degradable zinc-base micropore carried stent and preparation method thereof | |
| KR101786020B1 (en) | Stent for inhibiting restenosis by femtosecond laser processing and stimulating re-endothelialization and preparation method thereof | |
| Lamichhane et al. | Dextran sulfate as a drug delivery platform for drug‐coated balloons: Preparation, characterization, in vitro drug elution, and smooth muscle cell response | |
| BRPI1012815A2 (en) | electronic beam sterilization of medical devices comprising bioactive coating | |
| WO2010081393A1 (en) | Medicament eluting apparatus with micro-hole structure capable of storing and releasing multiple medicines and preparation method | |
| CN105457105A (en) | Novel developable magnesium alloy intravascular stent | |
| CN104984412A (en) | Preparation method for paclitaxel coating on surface of drug balloon | |
| WO2013044605A1 (en) | Interventional medical device and manufacturing method thereof | |
| CN201572353U (en) | Human body absorbable intravascular stent | |
| Tran et al. | Multifunctional surfaces through synergistic effects of heparin and nitric oxide release for a highly efficient treatment of blood-contacting devices | |
| CN102008758A (en) | Degradable bile duct support and preparation method thereof | |
| US9968717B2 (en) | Scaffold with drug coating for treating restenosis and preparation method thereof | |
| CN102274553A (en) | Coronary artery bracket with anticoagulant action and preparation method thereof | |
| CN103830777A (en) | REDV modification novel biodegradable coronary artery coating support | |
| KR20120103249A (en) | Stent for selectively capturing epc and process for producing the same | |
| CN100413540C (en) | Gene carrying rack and its producing method and use | |
| CN101209360A (en) | Method for preparing biological bracket | |
| CN101491468B (en) | Preparation method of gene coatings of medical device | |
| CN203861634U (en) | REDV modified novel biodegradable coronary eluting stent | |
| Haase et al. | Development and characterization of an ex vivo arterial long-term proliferation model for restenosis research |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| AD01 | Patent right deemed abandoned |
Effective date of abandoning: 20161130 |
|
| C20 | Patent right or utility model deemed to be abandoned or is abandoned |