CN103988836B - A kind of cell storage box - Google Patents
A kind of cell storage box Download PDFInfo
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- CN103988836B CN103988836B CN201410087660.8A CN201410087660A CN103988836B CN 103988836 B CN103988836 B CN 103988836B CN 201410087660 A CN201410087660 A CN 201410087660A CN 103988836 B CN103988836 B CN 103988836B
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- test tube
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- receiving hole
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Abstract
The present invention relates to the device for storing cell.A kind of cell storage box, comprise box, be provided with test tube storage rack and energy storage block in described box, described box comprises end box and upper cover, and box of the described end and upper cover are made by heat-insulating material.The invention provides the cell storage box that a kind of not power consumption can provide required temperature, the cupboard solved by being provided with air-conditioning system carries out preserving the power consumption that transport point exists, the problem of carrying inconvenience to cell.
Description
Technical field
The present invention relates to the device for storing cell, particularly relating to a kind of cell storage box.
Background technology
If freezing rate all can cause cell to lose activity too soon or too slowly when carrying out freezing to cell, when carrying out freezing to most cells, the freezing rate of cell controls lowering the temperature with the speed of 1 DEG C/min usually, but when carrying out freezing to different cells, freezing quick-frozen is also the same not to the utmost.Chinese Patent Application No. be 2011104362120, publication date be July 18 in 2012 day, be called in the patent document of " a kind of multipurpose cell freezing and frozen rear recovery container " and disclose a kind of cell freezing box.
Although cell freezing box can effectively prevent cell from destroying activity in refrigerating process.But need to be stored in after recovery in required temperature environment for different cells and carry out preservation transport, cell freezing box can not meet this demand.Existing way is that the cupboard having an air-conditioning system by design carries out preservations transport to cell, by air-conditioning system, the temperature in cupboard is met the requirements, carries out the existence of storages transport cells by the cupboard with air-conditioning system: power consumption, carry the deficiencies such as inconvenient.
Summary of the invention
The invention provides the cell storage box that a kind of not power consumption can provide required temperature, the cupboard solved by being provided with air-conditioning system carries out preserving the power consumption that transport point exists, the problem of carrying inconvenience to cell.
Above technical problem is solved by following technical proposal: a kind of cell storage box, comprises box, is provided with test tube storage rack and energy storage block in described box, and described box comprises end box and upper cover, and box of the described end and upper cover are made by heat-insulating material.During use, temperature requirement when preserving according to cell, select the energy storage block with this temperature, then cell being left in cell deposits in pipe, cell being deposited pipe is placed in test tube storage rack again, then by upper cover lid on earth box, energy storage block gives off energy and keeps the temperature-resistant cell that makes to be kept at this temperature, adiabatic end box and upper cover can effectively prevent the energy in space, box inside and outside from producing exchange, play the effect extended the time that cell stores at a set temperature, after the fault offset of energy storage block is complete, to energy storage block again accumulation of energy.Such as need to preserve at 0 ° cell, then utilize mixture of ice and water to work as energy storage block.
As preferably, described test tube storage rack is provided with some test tube receiving hole, at least three supporting rods extended in the horizontal direction are provided with in described test tube receiving hole, described supporting rod can be connected to test tube receiving hole by clamp springs horizontal extension, and the bare terminal end of described supporting rod is positioned at the polygonal inside that is projected as summit of bare terminal end along described test tube receiving hole depth direction of described supporting rod along the center of circle being projected as the polygonal circumscribed circle on summit of test tube receiving hole depth direction.During use, test tube is circumferentially clamped by supporting rod and leaves in test tube receiving hole, all can keep to the test tube of different size that sidewall large area is unsettled to be deposited, not only versatility is good but also that test tube temperature everywhere can be made all to change to the temperature of same energy storage block is the same thus keep the activity of cell better.
As preferably, inner sleeve is provided with in described test tube receiving hole, described inner sleeve comprises epimere and hypomere, described epimere hangs on described test tube receiving hole rotationally, described hypomere is threadedly connected to described epimere lower end, the chute extended along test tube receiving hole depth direction and the anti-rotation block being inserted in the prevention hypomere rotation in chute is provided with between described hypomere and test tube receiving hole, described hypomere is provided with thimble, and described thimble is positioned at the polygonal inside that is projected as summit of bare terminal end along described test tube receiving hole depth direction of described supporting rod.During use, the bottom that thimble withstands on test tube supports test tube.All can keep to the test tube of differing heights that diapire large area is unsettled to be deposited, not only versatility is good but also test tube temperature everywhere can be made further all consistent with the temperature of energy storage block thus keep the activity of cell better.
As preferably, described thimble upper end is provided with sucker.Can effectively prevent test tube from landing thimble, good connecting effect.
As preferably, the bare terminal end of described supporting rod is provided with rotating fulcrum ball.Can either make test tube with between supporting rod for point cantact, the unsettled area of point cantact then test tube is large, and temperature homogeneity is good; Point cantact can be prevented again and scratch test tube in the process of mobile test tube.
The present invention also comprises vavuum pump, drive the accumulator of vavuum pump, and the first thermo-electric generation sheet charged a battery and the second thermo-electric generation sheet, described upper exterior surface is enclosed with upper cover part shell, the tow sides of upper cover part shell are all provided with reflecting layer, upper cover part shell is with forming upper heat-insulation chamber between upper cover, upper cover part shell is made by Heat Conduction Material, box outer surfac of the described end is enclosed with box portion, end shell, the tow sides of box portion, end shell are all provided with reflecting layer, box portion, end shell is with forming lower heat-insulation chamber between end box, box portion, end shell is made by Heat Conduction Material, upper cover part shell and the sealing of box portion, end shell thermal conductivity are docking together, described upper heat-insulation chamber is communicated with lower heat-insulation chamber, the entrance point of described vavuum pump links together with described lower heat-insulation chamber, the low temperature face of described first thermo-electric generation sheet links together with described energy storage block thermal conductivity, the high temperature face of described first thermo-electric generation sheet links together with box portion shell thermal conductivity of the described end, the high temperature face of described second thermo-electric generation sheet links together with described energy storage block thermal conductivity, the low temperature face of described second thermo-electric generation sheet links together with box portion shell thermal conductivity of the described end.When external temperature is variant with the temperature of energy storage block, utilize temperature contrast generate electricity and vacuumize upper and lower heat-insulation chamber, to improve effect of heat insulation, thus play the effect extending energy storage block service time.Shell surfaces externally and internally is all provided with reflecting layer, can prevents box inside and outside from producing the effect of heat exchange further.
As preferably, described upper lid and bottom box is sealed connected together.Heat-insulation chamber can be made not to be communicated with the space of cassette interior, to reduce the heat transfer effect in space, box inside and outside further, to extend the service time of energy storage block.
As preferably, box of the described end comprises lower cover and tubular epimere, and described upper cover and lower cover shutoff are at the two ends up and down of described epimere, and described energy storage block is contained in described lower cover, the lower end pressure holding of described epimere is on described energy storage block, and described test tube storage rack is shelved on described energy storage block.To the good fixing effect of energy storage block.
As preferably, described energy storage block is provided with flanging, is covered with step under described, and described energy storage block is suspended in described lower cover on described step by described flanging clasp joint.The energy dissipation of energy storage block can be prevented further, play the effect of the service time extending energy storage block.
As preferably, described test tube storage rack is positioned at above described energy storage block, and described test tube storage rack upper surface is provided with mechanical thermometer.The temperature of cell can be known intuitively in energy-conservation mode.
The present invention has following advantage: by depositing energy storage block in the box made by heat-insulating material, cell is stored at a set temperature, energy-conservation, convenient transportation, easy to use, lightweight; Upper cover and base all make of heat-insulating material, can directly catch tactile when energy storage block temperature low when Cord blood (i.e. cell need).
Accompanying drawing explanation
Fig. 1 is the cross-sectional schematic of the embodiment of the present invention one.
Fig. 2 is the cross-sectional schematic of the embodiment of the present invention two.
Fig. 3 is the close-up schematic view at the A place of Fig. 2.
Fig. 4 is the schematic diagram of the test tube storage rack of embodiment three.
Fig. 5 is the close-up schematic view at the B place of Fig. 4.
Fig. 6 is the close-up schematic view at the C place of Fig. 4.
Fig. 7 is inner sleeve and the schematic diagram projected downwards along test tube receiving hole depth direction being connected to its upper-part.
In figure: box 1, end box 11, lower cover 111, first step 1111, second step 1112, epimere 112, first connects tongue 1121, 3rd step 1122, upper cover 12, second connects tongue 121, upper cover part shell 13, upper heat-insulation chamber 14, box portion, end shell 15, lower heat-insulation chamber 16, test tube storage rack 2, test tube receiving hole 21, inner sleeve 22, supporting rod 23, thimble 24, chute 25, anti-rotation block 26, fulcrum ball 27, sucker 28, clamp springs 29, energy storage block 3, flanging 31, vavuum pump 4, check valve 41, accumulator 5, charger 6, the bare terminal end of supporting rod is along the circumscribed circle 7 being projected as the quadrangle on summit of test tube receiving hole depth direction, the bare terminal end of supporting rod is along the quadrangle 8 being projected as summit of test tube receiving hole depth direction, first thermo-electric generation sheet 91, second thermo-electric generation sheet 92.
Embodiment
Below in conjunction with accompanying drawing and embodiment, the present invention is further illustrated.
Embodiment one, see Fig. 1, a kind of cell storage box, comprises box 1, test tube storage rack 2 and energy storage block 3.
Box 1 comprises end box 11 and upper cover 12.End box 11 comprises lower cover 111 and epimere 112.Lower cover 111 is shell-like structure.The sidewall of lower cover 111 is provided with first step 1111 and second step 1112.First step 1111 is positioned at the below of second step 1112.Epimere 112 is the tubular-shaped structures of both ends open.The lower end of epimere 112 is provided with annular first and connects tongue 1121.The upper end of epimere 112 is provided with the 3rd step 1122.First connect tongue 1121 with second step 1112 sidewall between tight fit and being sealed connected together.Upper cover 12 is shell-like structure.Upper cover 12 is provided with annular second and connects tongue 121.Second connect tongue 121 with the 3rd step 1122 sidewall between tight fit and being sealed connected together.Lower cover 111, epimere 112 are made by identical heat-insulating material with upper cover 12 three.
Energy-accumulation material in energy storage block 3 is mixture of ice and water, certainly can select other energy-accumulation material according to temperature needs.Energy storage block 3 is provided with flanging 31.Energy storage block 3 is suspended in lower cover 111 on first step 1111 by flanging 31 clasp joint.The surrounding of energy storage block 3 and bottom surface are with spaced apart between lower cover 111.Lower end (i.e. the lower end of the first connection tongue 1121) pressure holding of epimere 112 is on energy storage block 3.
Test tube storage rack 2 is provided with some test tube receiving hole 21.Test tube storage rack 2 is shelved on energy storage block 3.The upper surface of test tube storage rack 2 is provided with mechanical type thermometer (not drawing in figure).
During use, take off upper cover 12, the test tube depositing cell is placed on correspondingly in the test tube receiving hole 21 in test tube storage rack 2, then covers upper cover 12.Energy storage block 3 discharges or absorbs heat and makes the temperature of box 1 inside remain on respective value and carry out design temperature storage to cell.When energy storage block 3 fault offset complete and cause temperature can not maintain design temperature time, then again give energy storage block makeup energy.As with mixture of ice and water when temperature to be maintained 0 ° of degree left and right by energy storage block, when ice melt completely or freeze over time then need the mixture of ice and water that more renews.
Embodiment two, see Fig. 2, the difference with embodiment one is: also comprise vavuum pump 4, accumulator 5, charger 6, first thermo-electric generation sheet 91 and the second thermo-electric generation sheet 92.
Upper cover 12 outer surface is enclosed with upper cover part shell 13.The tow sides of upper cover part shell 13 are all provided with reflecting layer.Upper cover part shell 13 is made by Heat Conduction Material.Upper cover part shell 13 is with forming upper heat-insulation chamber 14 between upper cover 12.End box 12 outer surface is enclosed with box portion, end shell 15.The tow sides of box portion, end shell 15 are all provided with reflecting layer.Box portion, end shell 15 is made by Heat Conduction Material.Box portion, end shell 15 is with forming lower heat-insulation chamber 16 between end box 12.When upper cover covers on end box, box portion, end shell 15 and upper cover part shell 13 directly sealing are connected to together and realize thermal conductivity and be connected.Upper heat-insulation chamber 14 is communicated with lower heat-insulation chamber 16.
The entrance point of vavuum pump 4 links together with lower heat-insulation chamber 16.Accumulator 5 is for driving vavuum pump 4.The low temperature face of the first thermo-electric generation sheet 91 links together with energy storage block 3 thermal conductivity.The high temperature face of the first thermo-electric generation sheet 91 links together with box portion, end shell 15 thermal conductivity.The electric output of the first thermo-electric generation sheet 91 is linked together with accumulator 5 by charger 6, namely the first thermo-electric generation sheet 91 is for charging a battery.The high temperature face of the second thermo-electric generation sheet 92 links together with energy storage block 3 thermal conductivity.The low temperature face of the second thermo-electric generation sheet 92 links together with box portion, end shell 15 thermal conductivity.The electric output of the second thermo-electric generation sheet 92 is linked together with accumulator 5 by charger 6, namely the second thermo-electric generation sheet 92 charge a battery.In the present embodiment, upper cover part shell 13 and box portion, end shell 15 are all made from aluminum and form, and reflecting layer is for form in shell surface finish.
See Fig. 3, the entrance point of vavuum pump 4 is also provided with the check valve 41 opened towards vavuum pump.When vavuum pump 4 is stopped, gas can not be back in lower heat-insulation chamber 16 through vavuum pump entrance point.
In use procedure, the reflection side of upper cover part shell 13 and box portion, end shell 15 surfaces externally and internally plays and delays the effect that heat exchange is carried out carrying out in thermal-radiating mode in space, box inside and outside; When temperature (namely storing the temperature required for cell) higher than box 1 inside of the temperature (i.e. environmental temperature) of box 1 outside, then the first thermo-electric generation sheet 91 generates electricity and accumulators 5 charges, and accumulator 5 drives vavuum pump 4 to vacuumize to delay heat exchange to upper heat-insulation chamber 14 and lower heat-insulation chamber 16; Otherwise when temperature lower than box 1 inside of the temperature of box 1 outside, then the second thermo-electric generation sheet 92 generates electricity and accumulators 5 charges, and accumulator 5 drives vavuum pump 4 to vacuumize to delay heat exchange to upper heat-insulation chamber 14 and lower heat-insulation chamber 16.The box 1 inside and outside temperature difference is larger, mean that the energy of energy storage block 3 can be switched to the external world quickly, also namely energy storage block can shorten the holding time of cell, and this technical scheme can compensate the time be shortened, and makes temperature retention time be subject to extraneous interference few.
Embodiment three, the difference with embodiment two is:
See Fig. 4, in test tube receiving hole 21, be provided with inner sleeve 22, supporting rod 23 and thimble 24.
Inner sleeve 22 comprises epimere 221 and hypomere 222.Epimere 221 hangs on test tube receiving hole 21 rotationally.Hypomere 222 is threadedly connected to epimere 221 lower end.The chute 25 extended along test tube receiving hole depth direction and the anti-rotation block 26 being inserted in the prevention hypomere rotation in chute is provided with between hypomere 222 and test tube receiving hole 21.Chute 25 is arranged at the hole wall of test tube receiving hole 21.Anti-rotation block 26 is arranged at hypomere 222.Supporting rod 23 extends in the horizontal direction.Supporting rod 23 is arranged in epimere 221.Clamp springs 29 is provided with between supporting rod 23 and test tube receiving hole 21.Clamp springs 29 is stretched towards epimere 221 inside for making supporting rod 23.Thimble 24 is arranged at the diapire of hypomere 222.Thimble 24 vertically extends.
See Fig. 5, the bare terminal end of supporting rod 23 is provided with rotating fulcrum ball 27.One end that when bare terminal end of supporting rod refers to use, supporting rod contacts with test tube.
See Fig. 6, thimble 24 upper end is provided with sucker 28.
See Fig. 7, supporting rod 23 has four.The bare terminal end of supporting rod 23 is positioned at the inside of bare terminal end along the quadrangle 8 being projected as summit of test tube receiving hole depth direction of supporting rod along the center of circle of the circumscribed circle 7 being projected as the quadrangle on summit of test tube receiving hole depth direction.Thimble 24 is positioned at the inside of bare terminal end along the quadrangle 8 being projected as summit of test tube receiving hole depth direction of supporting rod.The bare terminal end of supporting rod is square along the quadrangle 8 being projected as summit of test tube receiving hole depth direction.
See Fig. 4 to Fig. 7, be: go to rotate epimere 221 according to the height being stored test tube and make hypomere 222 rise to the height of thimble 24 to required position the diapire of test tube is shelved on to adsorb on thimble 24 and by sucker 28 to prevent landing to the method that test tube is fixed.Three supporting rods 23 are clamped in the sidewall of test tube under the effect of clamp springs 29 with test tube contact by fulcrum ball 27.
Embodiment four, the difference with embodiment three is that supporting rod only has three.The bare terminal end of supporting rod is positioned at the leg-of-mutton inside that is projected as summit of bare terminal end along test tube receiving hole depth direction of supporting rod along the center of circle of the circumscribed circle at the projection place of test tube receiving hole depth direction.Thimble is positioned at the leg-of-mutton inside that is projected as summit of bare terminal end along test tube receiving hole depth direction of supporting rod.The bare terminal end of supporting rod is equilateral triangle along the triangle being projected as summit of test tube receiving hole depth direction.
Claims (8)
1. a cell storage box, it is characterized in that, comprise box, vavuum pump, drive the accumulator of vavuum pump, and the first thermo-electric generation sheet charged a battery and the second thermo-electric generation sheet, test tube storage rack and energy storage block is provided with in described box, described box comprises end box and upper cover, box of the described end is made by identical heat-insulating material with upper cover, described test tube storage rack is provided with some test tube receiving hole, at least three supporting rods extended in the horizontal direction are provided with in described test tube receiving hole, described supporting rod can be connected to test tube receiving hole by clamp springs horizontal extension, the bare terminal end of described supporting rod is positioned at the polygonal inside that is projected as summit of bare terminal end along described test tube receiving hole depth direction of described supporting rod along the center of circle being projected as the polygonal circumscribed circle on summit of test tube receiving hole depth direction, described upper exterior surface is enclosed with upper cover part shell, the tow sides of upper cover part shell are all provided with reflecting layer, upper cover part shell is with forming upper heat-insulation chamber between upper cover, upper cover part shell is made by Heat Conduction Material, box outer surfac of the described end is enclosed with box portion, end shell, the tow sides of box portion, end shell are all provided with reflecting layer, box portion, end shell is with forming lower heat-insulation chamber between end box, box portion, end shell is made by Heat Conduction Material, upper cover part shell and the sealing of box portion, end shell thermal conductivity are docking together, described upper heat-insulation chamber is communicated with lower heat-insulation chamber, the entrance point of described vavuum pump links together with described lower heat-insulation chamber, the low temperature face of described first thermo-electric generation sheet links together with described energy storage block thermal conductivity, the high temperature face of described first thermo-electric generation sheet links together with box portion shell thermal conductivity of the described end, the high temperature face of described second thermo-electric generation sheet links together with described energy storage block thermal conductivity, the low temperature face of described second thermo-electric generation sheet links together with box portion shell thermal conductivity of the described end.
2. a kind of cell storage box according to claim 1, it is characterized in that, inner sleeve is provided with in described test tube receiving hole, described inner sleeve comprises epimere and hypomere, described epimere hangs on described test tube receiving hole rotationally, described hypomere is threadedly connected to described epimere lower end, the chute extended along test tube receiving hole depth direction and the anti-rotation block being inserted in the prevention hypomere rotation in chute is provided with between described hypomere and test tube receiving hole, described hypomere is provided with thimble, described thimble is positioned at the polygonal inside that is projected as summit of bare terminal end along described test tube receiving hole depth direction of described supporting rod.
3. a kind of cell storage box according to claim 2, is characterized in that, described thimble upper end is provided with sucker.
4. a kind of cell storage box according to claim 1 or 2 or 3, is characterized in that, the bare terminal end of described supporting rod is provided with rotating fulcrum ball.
5. a kind of cell storage box according to claim 1 or 2 or 3, is characterized in that, described upper lid and bottom box is sealed connected together.
6. a kind of cell storage box according to claim 1 or 2 or 3, it is characterized in that, box of the described end comprises lower cover and tubular epimere, described upper cover and lower cover shutoff are at the two ends up and down of described epimere, described energy storage block is contained in described lower cover, the lower end pressure holding of described epimere is on described energy storage block, and described test tube storage rack is shelved on described energy storage block.
7. a kind of cell storage box according to claim 6, it is characterized in that, described energy storage block is provided with flanging, is covered with step under described, and described energy storage block is suspended in described lower cover on described step by described flanging clasp joint.
8. a kind of cell storage box according to claim 1 or 2 or 3, is characterized in that, described test tube storage rack is positioned at above described energy storage block, and described test tube storage rack upper surface is provided with mechanical thermometer.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410087660.8A CN103988836B (en) | 2014-03-12 | 2014-03-12 | A kind of cell storage box |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410087660.8A CN103988836B (en) | 2014-03-12 | 2014-03-12 | A kind of cell storage box |
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| CN103988836A CN103988836A (en) | 2014-08-20 |
| CN103988836B true CN103988836B (en) | 2015-12-30 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107318827B (en) * | 2017-07-03 | 2020-12-01 | 上海理工大学 | Medical speed-regulating and cooling device with communication function |
| CN111907888B (en) * | 2020-08-27 | 2021-11-05 | 赵彬 | Cell activation kit for medical cosmetology and use method thereof |
| CN114703137A (en) * | 2021-12-31 | 2022-07-05 | 浙江金时代生物技术有限公司 | Method for differentiating umbilical cord mesenchymal stem cells into neural stem cells by utilizing cryopreserved umbilical cord mesenchymal stem cells |
| CN115843786B (en) * | 2023-03-01 | 2023-07-14 | 基点生物科技(成都)有限公司 | Low-temperature storage device for biological samples |
| CN116806808B (en) * | 2023-03-17 | 2024-02-13 | 淮安市第二人民医院 | CAR-T cell cryopreservation box and cryopreservation method |
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| CN203618630U (en) * | 2013-09-30 | 2014-06-04 | 杭州柏恒科技有限公司 | Cell freezing vessel |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2010098971A (en) * | 2008-10-22 | 2010-05-06 | Miyazaki Prefecture | Container and method for preserving reproductive cell |
| CN203913153U (en) * | 2014-03-12 | 2014-11-05 | 杭州科默斯科技有限公司 | Cell storage container |
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| US20050208649A1 (en) * | 2002-04-30 | 2005-09-22 | Oliver Ringleb | Container for transporting biological material |
| CN202315975U (en) * | 2011-11-25 | 2012-07-11 | 成都康华生物制品有限公司 | Test tube stand box with refrigeration function |
| CN202464446U (en) * | 2012-03-07 | 2012-10-03 | 上海安集协康生物技术有限公司 | Thermal box for cold-chain transportation in pharmaceutical field |
| CN103704199A (en) * | 2013-09-30 | 2014-04-09 | 杭州柏恒科技有限公司 | Cell freezing box |
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