CN103987279A - Encapsulation of food ingredients supplements and pharmaceuticals - Google Patents
Encapsulation of food ingredients supplements and pharmaceuticals Download PDFInfo
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- CN103987279A CN103987279A CN201280055000.0A CN201280055000A CN103987279A CN 103987279 A CN103987279 A CN 103987279A CN 201280055000 A CN201280055000 A CN 201280055000A CN 103987279 A CN103987279 A CN 103987279A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
- A23L27/21—Synthetic spices, flavouring agents or condiments containing amino acids
- A23L27/215—Synthetic spices, flavouring agents or condiments containing amino acids heated in the presence of reducing sugars, e.g. Maillard's non-enzymatic browning
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/80—Emulsions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
Abstract
This invention relates to a composition comprising the reaction products of a mixture comprising: (a) an aqueous solution of at least one protein comprising free amino groups selected from the group consisting of casein, soy, whey, gelatine, egg, albumin, proteins from algal, yeast or fungal sources, and hydrolysed versions thereof, and/or at least one lipid comprising free amino groups, including fats, waxes and sterols selected from the group consisting of vegetable oil, fish oil and animal fats and mixtures thereof; and (b) at least one carbohydrate which contains a reducing sugar group, selected from the group consisting of, monosaccharide, disaccharide, trisaccharide, oligosaccharide, maltodextrin, resistant maltodextrins, starch, starch derived materials, glucose syrup, glucose syrup solids and honey; wherein the said at least one protein and/or at least one lipid, are reactive to the said at least one carbohydrate, such that when the mixture is heated for a period to allow sufficient Glycation lo occur without coagulation and dried, the composition is adapted for rehydration and formation of an encapsulant of oxygen sensitive oils and oxygen sensitive oil soluble bioactives.
Description
Quoting of related application
The application requires the priority of the Australian temporary patent application submitted on November 10th, 2011 numbers 2011904676, and its content is incorporated herein by introducing.
Technical field
The present invention relates to oxysensible oil separately or with at food composition, functional food, enriching substance (fill-in, additive, supplements), medicine, medical food, animal feed and dote on seal (parcel) of other bioactive materials combination that poultry used in food.Particularly, the present invention relates to, as the composition of sealing auxiliary agent, together with substituting processing aid, sealing the method for middle use with them.
Background technology
Those that contain oxysensible oil or oxysensible oil-soluble bioactivator are class far reaching food compositions.Belong to the oil with commercialization meaning of this class and other fat-soluble biological active material and normally contain those of cholesterol and polyunsaturated fatty acid.
Due to they sensitiveness to oxidation, these food compositions need to be in shielded form and the form that strengthens their ease for use.These food compositions need to be prepared with following form: the composition that is suitable as bread and cheese, novel foodstuff, functional food and nutritional drugs (nutraceuticals).It is stable storage that the form of described composition need to make them under conventional traffic condition.Conventionally, according to their final use, described composition is processed into stable W/O/W, Water-In-Oil or O/w emulsion, or encapsulates stable powder.
WO 01/74175 discloses micro-parcel of the oxysensible oil that contains the oxygen sensitive material of oil-soluble, and wherein protein reacts with the carbohydrate that contains reduced sugar group.Disclosed method is included in the aqueous mixture of temperature range coctoprotein and carbohydrate, has wherein formed saccharification (Glycation) (also referred to as nonenzymatic glycosylation effect (NEG)) product.Then, thus the oil phase that can reach 50wt% and the water emulsification that contains saccharification product form the oil particles of micropackaging.The emulsion of gained can be as food composition or the micro-oxysensible oil-bound distemper end of sealing of dry formation.
Saccharification product can demonstrate antioxidation activity in the situation that there is polyunsaturated fatty acid.In WO 01/74175, find that maillard reaction product (MRP) that the saccharification by protein and carbohydrate forms provides good sealing for oxysensible oil or oil-soluble composition.Maillard reaction is a kind of form of nonenzymatic browning reaction.It is to be produced by the chemical reaction between amino acid and reduced sugar, conventionally needs heating.Encapsulation agent forms stable and sane film around at oil droplet, and oxidation deterioration is demonstrated to the repellence of remarkable improvement.
The separation of saccharification in the middle of WO 01/74175 is not open.On the contrary, it discloses the formation of saccharification and micro-the sealing in same procedure of oxysensible oil occurs in sequence.Therefore, described whole method must occur in identical production plant, has therefore limited the flexibility of this production routine.
Any discussion that has been included in document in description of the present invention, bill, material, device, goods etc. should not thought that these materials of license any or all of formed the part on prior art basis or be the general knowledge in the field relevant with the present invention existing before the preferential date of every claim of the present patent application as it.
Summary of the invention
Target of the present invention, at least with its preferred form, it is acquisition saccharification composition with stable dry powder composite form under conventional traffic condition, thereby it can move to another position, move to oxygen sensitive oil and other oil dispersible bioactivator separately or in conjunction with homogenization together with substituting processing aid to form stable micro-encapsulated oil particle.
Therefore, of the present invention, aspect first, provide a kind of composition of the product that comprises mixture, this mixture comprises:
(a) aqueous solution of following material: the protein that at least one comprises free amino group (free amine group), the group that described protein selects free casein, soybean, whey, gelatin, egg, albumin, forms from albumen and the hydrolysed form thereof of marine alga, yeast or originated from fungus, and/or at least one lipid that comprises free amino group, it comprises fat, wax and sterol, the group that it selects free vegetable oil, fish oil and animal tallow and composition thereof to form; (b) at least one carbohydrate that contains reduced sugar group, the group that it selects material, glucose syrup, glucose syrup solids and the honey of free monose, disaccharides, trisaccharide, oligosaccharides, maltodextrin, resistant maltodextrin, starch, starch source to form;
Wherein said at least one protein and/or at least one lipid are reactive to described at least one carbohydrate, thereby when described mixture heating a period of time not being solidified to allow abundant saccharification occurs and when dry, the encapsulation agent of the suitable oxysensible oil of described composition and oxysensible oil-soluble bioactivator rehydrated and forming.
Therefore, aspect second of the present invention, provide a kind of composition of the product that comprises at least one additive and mixture, this mixture comprises:
(a) aqueous solution of following material: the protein that at least one comprises free amino group, the group that described protein selects free casein, soybean, whey, gelatin, egg, albumin, forms from albumen and the hydrolysed form thereof of marine alga, yeast or originated from fungus, and/or at least one lipid that comprises free amino group, it comprises fat, wax and sterol, the group that it selects free vegetable oil, fish oil and animal tallow and composition thereof to form; (b) at least one carbohydrate that contains reduced sugar group, the group that it selects material, glucose syrup, glucose syrup solids and the honey of free monose, disaccharides, trisaccharide, oligosaccharides, maltodextrin, resistant maltodextrin, starch, starch source to form; Wherein said at least one protein and/or at least one lipid are reactive to described at least one carbohydrate, thereby do not solidified and when dry to the encapsulation agent of the suitable oxysensible oil of described composition and oxysensible oil-soluble bioactivator rehydrated and forming before or after mixing with at least one additive described mixture heating a period of time to allow abundant saccharification occurs.
Aspect the 3rd of the present invention, provide a kind of and be used to form according to the method for the composition of described first aspect, comprise the following steps:
(a) prepare the aqueous mixture of at least one protein that comprises free amino group or lipid and at least one carbohydrate that contains reduced sugar group;
(b) described mixture heating a period of time is not solidified to allow abundant saccharification to occur; With
(c) described aqueous mixture is dry so that the composition of the rehydrated and formation of the encapsulation agent that is suitable for oxysensible oil and oxysensible oil-soluble bioactivator to be provided
According to a forth aspect of the invention, provide a kind of method that is used to form the emulsion of sealing oxysensible oil or oxysensible oil-soluble bioactivator, comprised the following steps:
(a) by according to described first or the composition of second aspect rehydrated in water, described composition contains at least one additive alternatively; With
(b) by described water with the oil phase homogenization that comprises oxysensible oil or oxysensible oil-soluble bioactivator to obtain emulsion.
According to a fifth aspect of the invention, provide a kind of method that is used to form the powder of sealing oxysensible oil or oxysensible oil-soluble bioactivator, comprised the following steps:
(a) by according to described first or the composition of second aspect rehydrated in water, described composition contains at least one additive alternatively; With
(b) by described water with the oil phase homogenization that comprises oxysensible oil or oxysensible oil-soluble bioactivator to obtain emulsion; With
(c) dry described emulsion is to form the powder of sealing.
In a sixth aspect of the present invention, provide according to described first or the application in the encapsulation agent of the oxysensible oil of preparation and oxysensible oil-soluble bioactivator of the composition of second aspect, wherein said encapsulation agent is used in food composition, functional food, additive, medicine, medical food and animal feed.
In causing result of the present invention, the present inventor finds that the saccharification dry powder composite of recovery and spraying are dried front standard saccharification emulsion-based originally quite.The inventor is surprised to find that dry saccharification powder composition can be by rehydrated and retain that it is functional for the first time.
In addition, saccharification dry powder composite can be used in conjunction with other processing aid (as maltodextrin), to form stable micro-packaged products, as the composition using in infant formula product.
The specific embodiment
In whole description, word " comprises " and version " comprises " or " containing " represents to comprise the group of illustrated element, integer or step or element, integer or step by being interpreted as, but does not get rid of the group of any other element, integer or step or element, integer or step.
As used herein, term " is sealed (packing) " and will be interpreted as and comprises term " micro-sealing " and " nanometer is sealed ".
In the preferred embodiment of the present invention, according to described first or the composition of the aqueous mixture of second aspect is dry by spraying, drum drying, freeze drying or film infiltration are dried.Most preferably, described aqueous mixture is dried by spraying.
Another preferred embodiment in, according to described first or second aspect described in composition comprise the carbohydrate of dextrose equivalent (DE) between 10 to 100%.Dextrose equivalent (DE) be the amount of the reduced sugar that exists in sugar product with respect to the measuring of glucose, it is expressed as the percentage based on dry weight.
According to described first or the protein of second aspect and/or lipid-carbohydrate mixture in the amount of nonenzymatic glycosylation effect be the important amount that is enough to provide for the given product shelf phase required antioxidation activity.Can monitor by the variable color degree occurring between the stage of reaction degree of the formed MRP of specified protein/carbohydrate combination.Alternatively, can monitor the amount of unreacted reduced sugar.
Of the present invention preferred embodiment in, according to described first or second aspect, the ratio of protein and carbohydrate depends on the type of used protein and carbohydrate.This ratio of protein and carbohydrate can be 1:10 to 10:1.
Any protein useful in encapsulated oil can be used as protein component of the present invention, as long as it has enough reactive free amino group with the effect of experience nonenzymatic glycosylation.That described protein is preferably solubility and need in the heated perimeter of Maillard reaction, stablize.To in the reaction of described protein and described carbohydrate, also need carefully to guarantee that condition can not cause described protein gel or solidify, because this forms good film when described protein can not and be formed in the rehydrated of O/w emulsion.
In the preferred embodiment of the present invention, according to described first or second aspect described in protein be casein, lactalbumin, whey protein concentrate or soy protein isolate.In multiple application, and larger tolerance to the heat treatment step of formation saccharification during gel and sex change low-cost due to it, therefore most preferred protein is casein.
According to of the present invention first or second aspect preferred embodiment in, at least one lipid that comprises free amino group acid groups can be genetic modification.In another embodiment, at least one lipid can be natural oil.In another embodiment, at least one lipid can be concentrate.
According to described first or the preferred embodiment of the present invention of second aspect in, at least one carbohydrate that contains reduced sugar group is monose, it is selected from glucose or fructose.Another preferred embodiment in, described carbohydrate is disaccharides, it is selected from maltose or lactose.
According to aspect the second, the 4th or the 5th preferred embodiment in, the group that at least one additive selects free surfactant, wetting agent, emulsifying agent, defoamer and dispersant to form.
Preferably, described additive selects the monoglyceride of free dioctyl sodium sulphosuccinate, aliphatic acid and diglyceride, lecithin, modified starch, xanthans, the group that sad and dimethyl silicone polymer forms.
The amount that adds the foam producing while being conducive to mix reconstruction sets compound by remarkable minimizing of surfactant or defoamer is easy to restore and cause the further improvement of non-oxidizability.Be not subject to the constraint of any concrete theory, this may be the formation due to film better in oil hydrosol, or may be when when adding surfactant or defoamer limit foam to form, and reduces relevant with the concentration of dissolved oxygen in water.
According to the described third aspect preferred embodiment in, in step (b), add before at least one additive afterwards and in step (c).According to the described third aspect another preferred embodiment in, in step (c) afterwards by being dry mixed or spraying to add at least one additive with lipid carrier.
According to aspect the described the 4th or the 5th preferred embodiment in, add at least one additive.Preferably, before described composition is rehydrated, at least one additive is dispersed in water.
First, second or the third aspect according to the present invention preferred embodiment in, the protein content in water be by weight 5 to 30%, together with 1 to 60% carbohydrate by weight.
According to first, second or the third aspect, the pH of water can be 4 to 10, preferably 6 to 8.Finally, the pH of water will depend on the isoelectric pH of used protein, and it can affect protein conversely in the solubility of each pH.To depend on the temperature of aqueous mixture heating the period of heating.For sensitive protein, in the lower temperature longer time of heating, can be applicable to.In the preferred embodiment of the present invention, the aqueous mixture of MRP is heated to 60-160 ℃.
Can to form humidity, be not more than 8% dry powder by the dry water that contains MRP of any conventional drying method.Preferably, water spraying is dry to form according to described first or the dry powder composite of second aspect.
According to described fourth aspect preferred embodiment in, described emulsion is stable liquid emulsifier.Another preferred embodiment in, described emulsion be superhigh temperature (UHT) process with aseptic packaging.
To understand aspect of the present invention first and second, in described composition, can comprise the food additives of any multiple approval.These additives comprise casein, lactalbumin, starch, maltodextrin and oligosaccharides.These additives can be with 1-99%w/w, 5-95%w/w preferably, and more preferably the amount of 20-90%w/w comprises.
Another preferred embodiment in, according to described first or second aspect described in composition also comprise oxysensible oil and at least one other processing aid, described processing aid is selected from maltodextrin, gelatin, gum arabic, modified starch, water soluble antioxidant, emulsifying agent.
As used herein, term " oxysensible oil " refers to oxysensible and dissolves or be dispersed in oil, fat or the oil-soluble product in oil phase.
In the present invention useful oil or oil-soluble product be in food and medicine, use to by those of oxidation deterioration sensitivity.These oil comprise polyunsaturated long-chain fatty acids; Can derive from one or more omega-fatty acids of marine source, plant origin, alga-derived or originated from fungus.Marine source can select the freely following group forming: crustacean is as krill, mollusk is as oyster, and fish is as tuna, salmon, trout, mackerel, sardine, sardine (pilchards), catfish (herring), redfish, eel, silverfish, catfish (menhaden) and jewfish.Plant origin (genetic modification and non-genetic modification) can select the freely following group forming: linseed, English walnut, sunflower seed, rapeseed oil, safflower oil, soybean, wheat embryo, greens and corn oil.Described one or more omega-fatty acids can be used as fish oil composition and are present in described composition.Fish oil can be sealed, for example, micro-sealing.Fish oil can select the freely following group forming: salmon oil, trout oil, tunny fish oil, mackerel oil, jewfish oil, pilchardine, herring oil and pilchard oil.According to the present invention, can also seal oxysensible fat of dairy product or other fat.This comprises the oil of change, as concentrate.The oil-soluble bioactivator that needs protection not oxidized includes, but is not limited to vitamin A [retinol], vitamin D [calciferol], vitamin E, tocopherol, fertility triol, vitamin K [benzoquinones] and beta carotene [provitamin A].
In the preferred embodiment of the present invention, described oil or oil-soluble product can be genetic modifications.In another embodiment, described oil is natural oil.In another embodiment, described oil or oil-soluble product are concentrate.
The emulsion of preparing according to the of the present invention the 4th and the 5th aspect and powder are suitable as the composition in strengthening infant formula, baby food, Yoghourt, beverage, UHT beverage, pasta product, bread and bakery product, process cheese, medical food, medicine, nutrition thing etc.They also can be used as ice cream, dairy dessert, for the alternative source of oil & fat in milk products, soup stock and filling dairy products.Powder also can be suitable for using in nutritional drugs application.
In an embodiment of the invention, according in the method aspect the described the 3rd, the 4th and the 5th, the water in step (a) is heated at least room temperature (approximately 20 ℃).
According in another embodiment aspect the described the 4th or the 5th, after described composition is rehydrated and added carrier before water and oil phase homogenization.In a preferred embodiment, described carrier is casein, lactalbumin, starch, maltodextrin and/or oligosaccharides.
In an embodiment of the invention, according to the described the 4th or the method for the 5th aspect, dry compositions exists with the amount of 5-95wt%.Described method preferred embodiment in, described dry compositions exists with the amount of 10-80wt%.Another preferred embodiment in, described dry compositions exists with the amount of 10-50%.Another preferred embodiment in, described dry compositions exists with the amount of 40-50%.Preferably, spray-dired composition exists with the amount of 20wt%.Most preferably, spray-dired composition exists with the amount of 50wt%.
To understand aspect the of the present invention the 4th or the 5th, in described composition, can comprise the food additives of any multiple approval.These additives comprise casein, lactalbumin, starch, maltodextrin, water soluble antioxidant and oligosaccharides.These additives can be with 1-99%w/w, 5-95%w/w preferably, and more preferably the amount of 20-90%w/w comprises.
In yet another embodiment of the present invention, according in the method aspect the described the 4th and the 5th, at least one other processing aid is selected from maltodextrin, gelatin, gum arabic, modified starch, water soluble antioxidant, emulsifying agent.
In yet another embodiment of the present invention, according in the method aspect the described the 4th or the 5th, oil phase heap(ed) capacity is 10-80%w/w, preferably 10-70%w/w.In one embodiment, oil phase heap(ed) capacity is 25%w/w.In another embodiment, oil phase heap(ed) capacity is 50%w/w.
In yet another embodiment of the present invention, according to the described the 4th and the homogenization step of the 5th aspect preferably with 350/100 bar, carry out.
In yet another embodiment of the present invention, according to the described the 4th and the 5th aspect, the granular size of disperseing in emulsion is 1 to 10 micron.The granular size of disperseing in emulsion in another embodiment, is 1-5 micron.The granular size of preferably, disperseing in emulsion is less than 1 micron.The granular size of most preferably, disperseing in emulsion is approximately 0.3 micron.
In another embodiment of method disclosed herein, spraying drying steps is used spray dryer to carry out; In whole spray-drying process, the charging that contains 30-42% total dissolved solidss is maintained at least 40 ℃, preferably 60-65 ℃; And entrance and exit air themperature is respectively 180 ℃ and 80 ℃.
Illustrative embodiments
A. the composition that comprises the product of mixture, this mixture comprises:
(a) aqueous solution of following material: the protein that at least one comprises free amino group, the group that described protein selects free casein, soybean, whey, gelatin, egg, albumin, forms from albumen and the hydrolysed form thereof of marine alga, yeast or originated from fungus, and/or at least one lipid that comprises free amino group, it comprises fat, wax and sterol, and it is selected from vegetable oil, fish oil and animal tallow and composition thereof; (b) at least one carbohydrate that contains reduced sugar group, the group that it selects material, glucose syrup, glucose syrup solids and the honey of free monose, disaccharides, trisaccharide, oligosaccharides, maltodextrin, resistant maltodextrin, starch, starch source to form;
Wherein said at least one protein and/or at least one lipid are reactive to described at least one carbohydrate, thereby when described mixture heating a period of time not being solidified to allow abundant saccharification occurs and when dry, the encapsulation agent of the suitable oxysensible oil of described composition and oxysensible oil-soluble bioactivator rehydrated and forming.
B. according to the composition described in illustrative embodiments A, wherein said composition is dry by spraying, drum drying, freeze drying or film infiltration are dried.
C. according to the composition described in illustrative embodiments B, wherein said composition is dried by spraying.
D. according to the composition described in any one in illustrative embodiments A-C, the glucose equivalent of the merging of wherein said at least one carbohydrate (DE) value is 10-100%.
E. according to the composition described in any one in illustrative embodiments A-D, the ratio of wherein said protein and carbohydrate is 1:10 to 10:1.
F. according to the composition described in any one in illustrative embodiments A-E, wherein said at least one protein is casein, whey or soy protein isolate.
G. according to the composition described in any one in illustrative embodiments A-F, wherein said at least one carbohydrate is monose, and described monose is selected from glucose or fructose.
H. according to the composition described in any one in illustrative embodiments A-F, wherein said at least one carbohydrate is disaccharides, and described disaccharides is selected from maltose or lactose.
I. the composition that comprises the product of at least one additive and mixture, this mixture comprises:
(a) aqueous solution of following material: the protein that at least one comprises free amino group, the group that described protein selects free casein, soybean, whey, gelatin, egg, albumin, forms from albumen and the hydrolysed form thereof of marine alga, yeast or originated from fungus, and/or at least one lipid that comprises free amino group, it comprises fat, wax and sterol, the group that it selects free vegetable oil, fish oil and animal tallow and composition thereof to form; (b) at least one carbohydrate that contains reduced sugar group, the group that it selects material, glucose syrup, glucose syrup solids and the honey of free monose, disaccharides, trisaccharide, oligosaccharides, maltodextrin, resistant maltodextrin, starch, starch source to form; Wherein said at least one protein and/or at least one lipid are reactive to described at least one carbohydrate, thereby do not solidified and when dry to the encapsulation agent of the suitable oxysensible oil of described composition and oxysensible oil-soluble bioactivator rehydrated and forming before or after mixing with at least one additive described mixture heating a period of time to allow abundant saccharification occurs.
J. according to the composition described in illustrative embodiments I, wherein said at least one additive selects the group of free surfactant, wetting agent, emulsifying agent, defoamer and dispersant composition.
K. according to the composition described in illustrative embodiments J, wherein said at least one additive selects the monoglyceride of free dioctyl sodium sulphosuccinate, aliphatic acid and diglyceride, lecithin, modified starch, xanthans, the group that sad and dimethyl silicone polymer forms.
L. be used to form according to the method for the composition described in any one in illustrative embodiments A-K, comprise the following steps:
(a) prepare the aqueous mixture of at least one protein that comprises free amino group or lipid and at least one carbohydrate that contains reduced sugar group;
(b) described mixture heating a period of time is not solidified to allow abundant saccharification to occur; With
(c) described aqueous mixture is dry so that the rehydrated composition with forming of encapsulation agent that is suitable for oxysensible oil and oxysensible oil-soluble bioactivator to be provided
M. according to the method described in illustrative embodiments L, wherein at least one additive adds afterwards and in step (c) before in step (b).
N. according to the method described in illustrative embodiments L, wherein at least one additive is by what use lipid carrier, to be dry mixed or to spray interpolation afterwards in step (c).
O. according to the method described in illustrative embodiments M or N, wherein said at least one additive selects the group of free surfactant, wetting agent, emulsifying agent, defoamer and dispersant composition.
P. according to the method described in illustrative embodiments O, wherein said at least one additive selects the monoglyceride of free dioctyl sodium sulphosuccinate, aliphatic acid and diglyceride, lecithin, modified starch, xanthans, the group that sad and dimethyl silicone polymer forms.
Q. according to the method described in any one in illustrative embodiments L-P, wherein said aqueous mixture is dry by spraying, drum drying, freeze drying or film infiltration are dried.
R. according to the method described in illustrative embodiments Q, wherein said aqueous mixture is dried by spraying.
S. according to the method described in any one in illustrative embodiments L-R, the protein component in wherein said aqueous mixture exists in 1 to 30% scope by weight, and described carbohydrate ingredient exists in 1 to 60% scope.
T. according to the method described in any one in illustrative embodiments L-S, wherein described in step (b), mixture heats in the scope of 60-160 ℃.
U. a method that is used to form the emulsion of sealing oxysensible oil or oxysensible oil-soluble bioactivator, comprises the following steps:
(a) by rehydrated in water according to the composition described in any one in illustrative embodiments A-K, described composition contains at least one additive alternatively; With
(b) by described water with the oil phase homogenization that comprises oxysensible oil or oxysensible oil-soluble bioactivator to obtain emulsion.
V. according to the method described in illustrative embodiments U, wherein said at least one additive was dispersed in described water before described composition is rehydrated.
W. a method that is used to form the powder of sealing oxysensible oil or oxysensible oil-soluble bioactivator, comprises the following steps:
(a) by rehydrated in water according to the composition described in any one in illustrative embodiments A-K, described composition contains at least one additive alternatively; With
(b) by described water with the oil phase homogenization that comprises oxysensible oil or oxysensible oil-soluble bioactivator to obtain emulsion; With
(c) dry described emulsion is to form the powder of sealing.
X. according to the method described in illustrative embodiments W, wherein said at least one additive was dispersed in described water before described composition is rehydrated.
Y. according to the method described in any one in illustrative embodiments T-X, wherein after described composition is rehydrated and before by described water and described oil phase homogenization, add at least one carrier.
Z. according to the method described in illustrative embodiments Y, wherein said carrier selects the group of free casein, lactalbumin, starch, maltodextrin and oligosaccharides composition.
AA. according to the method described in any one in illustrative embodiments U-Z, wherein said at least one additive selects the group of free surfactant, wetting agent, emulsifying agent, defoamer and dispersant composition.
AB. according to the method described in illustrative embodiments AA, wherein said additive selects the monoglyceride of free dioctyl sodium sulphosuccinate, aliphatic acid and diglyceride, lecithin, modified starch, xanthans, the group that sad and dimethyl silicone polymer forms.
AC. according to the method described in illustrative embodiments W or X, wherein said emulsion is dry by spraying, drum drying, freeze drying or film infiltration are dried.
AD. according to the method described in illustrative embodiments AC, wherein said emulsion is dried by spraying.
AE. according to the method described in any one in illustrative embodiments U to AD, wherein said oil phase is selected from oil, fat of dairy product, algae oil, the fungal oil of long-chain polyunsaturated fatty acid, marine source; The oil of plant origin and oil-soluble composition, comprise vitamin A [retinol], vitamin D [calciferol], vitamin E, tocopherol, fertility triol, vitamin K [benzoquinones] and beta carotene [provitamin A].
AF. according to the method described in any one in illustrative embodiments L-T, wherein said composition exists with the amount of 1-99wt%.
AG. according to the method described in any one in illustrative embodiments L-T, wherein said composition exists with the amount of 20-80wt%.
AH. according to the method described in any one in illustrative embodiments U-AE, wherein said oil phase heap(ed) capacity is 10-70%.
AI. according to the method described in any one in illustrative embodiments U-AE, wherein said oil phase heap(ed) capacity is 25-60%.
AJ. according to the method described in any one in illustrative embodiments U-AE, wherein said composition exists in the scope of the 10-80% of dry weight.
AK. according to the method described in any one in illustrative embodiments U-AE, wherein said composition exists in the scope of the 10-50% of dry weight.
AL. according to the method described in any one in illustrative embodiments U-AE, wherein said composition exists in the scope of the 40-50% of dry weight.
AM. according to the method described in any one in illustrative embodiments U-AL, wherein said homogenization step is carried out with 350/100 bar.
AN. according to the method described in any one in illustrative embodiments U-AM, the granular size of disperseing in wherein said emulsion is 1 to 10 micron.
AO. according to the method described in any one in illustrative embodiments U-AM, the granular size of disperseing in wherein said emulsion is 1 to 5 micron.
AP. according to the method described in any one in illustrative embodiments U-AM, the granular size of disperseing in wherein said emulsion is for being less than 1 micron.
AQ. according to the method described in any one in illustrative embodiments U-AM, the granular size of disperseing in wherein said emulsion is approximately 0.3 micron.
AR. the application in the encapsulation agent of the oxysensible oil of preparation and oxysensible oil-soluble bioactivator according to the composition described in any one in illustrative embodiments A-K, wherein said encapsulation agent comprises formula food and animal feed for food, food composition, functional food, additive, medicine, medical food, baby food.
Implement mode of the present invention
In order to understand better essence of the present invention, now some embodiment will be described as follows:
Spray-dired composition-the general procedure of saccharification product
Protein is dispersed in water at 50-60 ℃, and makes its aquation at least 30 minutes in water-bath.Then, add carbohydrate and pH is adjusted to required pH.Then, be cooled to before 50 ℃, protein-carbohydrate mixture is being heated to 30-90 minute at 90-100 ℃.Then, use the Production Minor pilot scale spray dryer with rotary atomizer that saccharification mixture is dried.Before atomization, charging is heated to 60 ℃, entrance and exit air themperature is respectively 180 ℃ and 80 ℃.
a: contrast
Step 1: the aqueous solution of saccharification product:
1. add water; Be heated to 55 ℃
2. add casein sodium, be heated to 60-65 ℃
3. aquation is 30 minutes
4. add a glucose monohydrate and maltodextrin and stir 10 minutes
5. with sodium hydroxide solution (6obaume), pH is adjusted to pH7-7.5
6. by being distilled at 100 ℃, mixture within 50 minutes, carries out saccharification
The emulsion that saccharification product is final:
7. weigh saccharification solution and be heated to 60-65 ℃
8. add the sodium ascorbate in the water that is dissolved in reservation
9. add deep fat phase (60-70 ℃), high shear mixing 5 minutes
10. use the two-stage homogenizer (two stage homogeniser-1pass) of 1 passage with 350/100 bar homogenate
11. with 180 ℃ of inlet temperatures: 80 ℃ of sprayings of outlet temperature dry (production minor-rotary atomizer) (by 39% feeding-in solid body to drier)
12. collect and packing under controlled atmospheric packing (MAP).
b: saccharification product drying, recovery and dry
Step 1: the aqueous solution of saccharification product:
| Component | Wt(kg) |
| Casein sodium | 6.82 |
| One glucose monohydrate | 6.81 |
| Maltodextrin | 6.84 |
| The initial water using | 42.28 |
| PH regulates water | 0.87 |
| Total water | 63.62 |
1. add water; Be heated to 55 ℃
2. add casein sodium, be heated to 60-65 ℃
3. aquation is 30 minutes
4. add a glucose monohydrate and maltodextrin and stir 10 minutes
5. with sodium hydroxide solution (6obaume), pH is adjusted to pH7-7.5
6. at 100 ℃, distill and within 50 minutes, carry out saccharification
7. be kept for step 2 and 3
Step 2: for spray-dired saccharification product water solution (dry premixed powder)
1. weigh the initial saccharification aqueous solution and be heated to 60-65 ℃
2. sodium ascorbate is joined in the water of reservation, make its dissolving and join in unitary fluid.
3. with 180 ℃ of inlet temperatures: 80 ℃ of outlet temperatures spraying dry (production minor-rotary atomizer) (by the feeding-in solid body of 30-32% (w/w) to drier)
4. collect and pack dry saccharification product powder
Step 3: for the final spray-dired saccharification pre-mixed formulation of emulsion (recovery)
| Component | Wt(kg) |
| Dry saccharification product | 5.33 |
| Water | 16.16 |
| Oil phase | 5.00 |
| Final solution | 26.49 |
1. weigh dry saccharification product
2. add water rehydrated at 60-60 ℃
3. add deep fat phase (60-70 ℃), high shear mixing 5 minutes
4. use the two-stage homogenizer (two stage homogeniser-1pass) of 1 passage with 350/100 bar homogenate
5. with 180 ℃ of inlet temperatures: 80 ℃ of outlet temperatures spraying dry (production minor-rotary atomizer) (by the feeding-in solid body of 39%w/w to drier)
6. collect and pack under MAP
According to producing following test products for the operation sequence of micro-encapsulation process below.
Micro-sealing-general procedure
Heat water between 40 to 65 ℃, will be dried saccharification product and disperse and stir and make its aquation in water-bath gently.If need, add at this moment glucose syrup solids, emulsifying agent and/or glucose.Add sodium ascorbate solution, add subsequently oil phase, use Silverson high-shear mixer mixed at high speed 5 minutes, thereby be enough to form thick emulsion.Then, use Rannie pilot scale high pressure homogenizer with the pressure of 350/100 bar by the reactant mixture homogenate of gained.
The emulsion of gained is directly used in application subsequently, or its superhigh temperature (UHT) is processed and aseptic packaging, or use with the pilot scale Production Minor spray dryer of rotary atomizer and sprayed and be dried.In whole spray-drying process, the charging that contains 39% total dissolved solidss is remained on to 65 ℃, and entrance and exit air themperature is respectively 180 ℃ and 80 ℃.
The character of spray-dired serosity combination
A. saccharification product contrast (having loaded the powder-Separation-free of 48% oil)
B. the saccharification product (having loaded the powder of 48% oil) restoring
Table 1 contrast (A) saccharification product contrast powder and (B) saccharification are restored and the comparative result of dry powder:
| Test | A | B |
| Peroxide value (milliequivalent 02/kg fat) | 0.9 | 1.0 |
| P-anisidine value | 6.0 | 8.0 |
| Acid number (mg KOH/g fat) | 0.4 | 0.4 |
| Total fat (%) | 48.4 | 48.2 |
| Vitamin C (mg/g) | 43.0 | 36.0 |
| Bulk density (g/ml) | 0.41 | 0.43 |
| Surface is fat (%) freely | 0.30 | 0.30 |
| Average powder size (μ m) | 48.0 | 47.0 |
| Average emulsion particle size (μ m) | 0.37 | 0.43 |
| Burnt grain | - | - |
| Humidity (%) | 1.40 | 1.20 |
Use the bulk density (100taps) of the method for explanation in AS2300.4.3 (1994)
Briefly, table 1 shows that recovery and spray-dired saccharification sample are equivalent to control sample.Sensory results is suitable with non-oxidizability result.Raw material have been carried out to " equivalence " shelf life of further 24 months, compared oxidation results and sensory results,, after sealing program, between the saccharification outturn sample that use is restored and saccharification product control sample, do not demonstrated recognizable difference.
In accompanying drawing 1-7, shown the result that shelf life is evaluated.
Sensory results:
Scale: ocean and rancid smell and local flavor (15=does not detect 0=and detects)
Oeverall quality (it is unacceptable that 15=can accept 0=)
Oxidation results:
The special allusion quotation of GOED (GOED voluntary monograph)
TOTOX maximum 26 (result of calculating, (2 * PV)+AV)
Anisidine value maximum 20; AOCS official method Cd 18-19
The maximum 5meq/kg of peroxide value; AOCS official method Cd 8-53
The maximum 3mg KOH/g of acid number; AOCS official method Cd 3d-93
Fig. 1 has shown that saccharification contrast powder restores the sensory results of powder in 24 months equivalent storage process with respect to saccharification.At 40 ℃, keep being similar to for 24 weeks the real-time storage of 24 months.
Fig. 2 has shown that saccharification contrast powder restores the TOTOX value of powder in 24 months equivalent storage process with respect to saccharification.At 40 ℃, keep being similar to for 24 weeks the real-time storage of 24 months.
Fig. 3 has shown that saccharification contrast powder restores the anisidine value of powder in 24 months equivalent storage process with respect to saccharification.At 40 ℃, keep being similar to for 24 weeks the real-time storage of 24 months.
Fig. 4 has shown that saccharification contrast powder restores the peroxide value of powder in 24 months equivalent storage process with respect to saccharification.At 40 ℃, keep being similar to for 24 weeks the real-time storage of 24 months.
Fig. 5 has shown that saccharification contrast powder restores the acid number of powder in 24 months equivalent storage process with respect to saccharification.At 40 ℃, keep being similar to for 24 weeks the real-time storage of 24 months.
Fig. 6 has shown that saccharification contrast powder restores ω-3 and the DHA content of powder in 24 months equivalent storage process with respect to saccharification.At 40 ℃, keep being similar to for 24 weeks the real-time storage of 24 months.
Fig. 7 has shown that saccharification contrast powder restores the total fat (%) of powder in 24 months equivalent storage process with respect to saccharification.At 40 ℃, keep being similar to for 24 weeks the real-time storage of 24 months.
stability test
For A-saccharification product contrast, prepare and evaluated some versions (the saccharification product that B-restores, V4, V6, V8, V9).In following table 2, shown that test changes the details of preparation.The target of this research is to evaluate the stability of prototype powder and performance and they in the minimizing gradually (table 2) that adds and do not add the absolute ratio of use in the intended application of surfactant and dry saccharification powder and swelling agent.
Table 2 test changes preparation
Micro-sealing-for the preparation of the general procedure of V4, V6, V8, V9
Heat water to 55 ℃, if now need to add maltodextrin, then add sodium ascorbate solution.Oil phase (is added as required,
90-35) be heated to 60-70 ℃, and join water under constant agitation in to form thick emulsion.Then, use Rannie pilot scale high pressure homogenizer with the pressure of 350/100 bar by the reactant mixture homogenate of gained.Then, use pilot scale NIRO FSD two-stage spray dryer that emulsion spraying is dry.In whole spray-drying process, the charging that contains 39% total dissolved solidss is remained on to 65 ℃, and entrance and exit air themperature is respectively 180 ℃ and 80 ℃.Collect gained powder, and in the lower packing of 100% food stage nitrogen (residual oxygen <3%).
Test procedure
Use test procedure as shown in table 3 to evaluate version and contrast.Particularly:
By oxidation stability-" ML-Oxipres " of monitors oil induction period in heterogeneous product
Raw material and intended application are exposed to high temperature-" accelerating shelf life determines " in damp-prrof packing under adjusting atmosphere
Table 3: oxidation stability test matrix
ML-Oxipres
For the oil oxidation stability in the heterogeneous product of monitoring by induction period, evaluated version in table 2.Use ML Oxipres (Mikrolab Aarhus A/S Denmark) to analyze oil.By the sample weighing that contains minimum 4g fat (oil) in reactor pressure vessel and be placed in MLOxipres pressure vessel and sealing.To the restriction initial pressure that is filled with oxygen to 5 bar (70psi) in container.Container is placed on to preheating and remains on the isothermal block (thermostat block) of 70 ℃.Record pressure variation and on figure, draw curve.By being calculated as induction period from recording the pressure of measuring at the cross section point of contact of the first and second parts of the curve that pressure changes, start the time after fast reducing.
The test of acceleration shelf life
To under vacuum, be packaged into powder micropackaging in 100g paillon foil pouch (5 layers of laminate) and at artificial atmospher's lower seal of standard food level 100% nitrogen.
Pouch is stored to 24 weeks-18 ℃ (contrasts) and 40 ℃.
Within 24 months, accelerate the research of shelf life simulating storage
At 40 ℃, preserve within 1 week, to be similar under 1 environment (20-25 ℃) condition and store 1 month
At baseline (0), the interval sampling of 6,12,18 and 24 weeks.
Acceleration shelf life test procedure in application
Add 1 section of infant formula of test prototype
The K type blade that use is arranged on the kitchen mixer of middling speed is mixed in basic substance micro-powder of sealing to realize required activity
Sample is packaged under vacuum in 100g paillon foil pouch (5 layers of laminate) and at artificial atmospher's lower seal of standard food level 100% nitrogen.
By pouch in-18 ℃ (contrasts) and 40 ℃ of storage test time periods
Within 24 weeks, accelerate the research of shelf life simulating storage
Within 24 months, accelerate the research of shelf life simulating storage
Basic shelf life (table 4 and table 5) is determined in the combination of stability in use and sensorial data.
Table 4: stability test
| For micro-test parameter of sealing | Method of testing |
| Determining with quantitative of aliphatic acid | AOCS?Ce?1B-89 |
| Total fat | AS2300.1.3 |
| Acid number | AOCS?Ca?5a-40 |
| Free fatty | AOCS?Cd?3d-63 |
| Peroxide value | AOCS?Cd?8-53c |
| Anisidine value | AOCS?Cd?18-90c |
Table 5: sensory testing
| For micro-test parameter * sealing | Method of testing |
| Rancid smell | Do not exist/can detect |
| Fresh ocean smell | Do not exist/can detect |
| Putrefactive odor | Do not exist/can detect |
| Fresh marine flavor | Do not exist/can detect |
| Oeverall quality | Can accept/unacceptable |
Result:
Prototype comparison
In table 6, describe the comparison of the Main physical chemical property of test version in detail.For humidity and bulk density, all changes form all meets object prototype spectrum.Except preparation only comprises the test version of 10% dry saccharification powder (V8), all test versions are all lower than for the specified maximum (table 6) of surperficial free-fat.Surperficial free-fat indifference between sample A and sample B, this show seal the dry recovery of premix and spraying dry in encapsulation efficiency be without prejudice.Enjoyably, with with identical premix concentration, refill maltodextrin DE10 and compare, use refilling of maltodextrin DE30 to cause that product surface free-fat is lower to be reduced to 10% of butt weight by the percentage of dry saccharification powder in capsule wall and to cause product to have poor micro-effect of sealing, its free surface-fat higher (7.5%).
Table 6: physicochemical properties
ML?Oxipres：
Fig. 8 has shown the induction period of test powder under 70 ℃ and 5 bar pressures.For induction period (IP), two kinds of test versions have surpassed object prototype spectrum.That is to say, IP at 70 ℃ over 60 hours; Test version B (the saccharification product of recovery) and V4 (Fig. 8).Test version V4 has recorded than the IP of A (restoring saccharification product) large 13%, because these two kinds of versions have essentially identical formula, only difference is in assay format 4, to have added 0.5% emulsifying agent, and the reason therefore improving by the definite oxidation stability of IP it be unclear that.Yet possible is to add emulsifying agent may cause larger encapsulation efficiency in oil phase; Although the physical chemistry result (table 6) of these test versions, surperficial free-fat is not supported this hypothesis particularly.Remaining test version (version 6,8 and 9) demonstrates substantially suitable oxidation stability, as measured by induction period, is wherein only recorded to small difference (Fig. 8).
Result is summed up
In Fig. 9-16, shown the result from stability test.
Fig. 9 has shown the total fat (%) in test powder while exposing 24 weeks under accelerating temperature conditions.
Figure 10 has shown the concentration (mg/g) of the active material in test powder while exposing 24 weeks under accelerating temperature conditions.
Figure 11 has shown percentage and the acid number of the free fatty in test powder while exposing 24 weeks under accelerating temperature conditions.
Figure 12 has shown primary oxidation (peroxide value (PV)) and the secondary oxidative (P-anisidine (PAV)) of test powder while exposing 24 weeks under accelerating temperature conditions.
Figure 13 has shown the overall aesthetic quality who tests raw material A, B and V4 while exposing 24 weeks under accelerating temperature conditions
Figure 14 has shown the overall aesthetic quality who tests raw material V6, V8 and V9 while exposing 24 weeks under accelerating temperature conditions
Figure 15 has shown the overall aesthetic quality who tests raw material A, B and V4 while exposing 24 weeks in adding infant formula application to and under acceleration temperature conditions.
Figure 16 has shown the overall aesthetic quality who tests raw material V6, V8 and V9 while exposing 24 weeks in adding infant formula application to and under acceleration temperature conditions.
By dry and follow-up rehydrated good membranes formation and the anti-oxidant removing possibility that saccharification product does not damage described saccharification product of further processing of spraying.In addition, further processing can not reduce the ability that it forms stable spray-dired O/w emulsion.As additive, add emulsifying agent that better oxidation stability can be provided, as proved induction period by longer.The percentage of dry saccharification powder in capsule wall is reduced to 22% of butt weight causes described powder to have sense organ acceptability and the oxidation stability substantially suitable with contrasting powder.Yet, the percentage of dry saccharification powder in capsule wall being reduced to 10% of butt weight and can causing powder to there is the surperficial free-fat of unacceptable height, this shows that the threshold value reducing is 10% (table 6) of butt weight in preparation.Accelerate shelf stable and show that all test powder keep oxidation-stabilized (Fig. 9-12) within the testing period of 24 weeks.In addition, all test powder keep sense organ can accept (Figure 13-14) the accelerated test of 24 weeks in the phase.In addition, think that test version is applicable to target infant formula application (Figure 15-16).
It will be appreciated by those skilled in the art that in the situation that not deviating from broadly described scope of the present invention, as shown in the specific embodiment, can make multiple change and/or variation to the present invention.Therefore,, from all aspects, think that present embodiment is illustrative and not restrictive.
Claims (44)
1. a composition that comprises the product of following mixture, comprises:
(a) aqueous solution of following material: at least one protein that comprises free amino group, the group that described protein selects free casein, soybean, whey, gelatin, egg, albumin, forms from albumen and the hydrolysed form thereof of marine alga, yeast or originated from fungus, and/or at least one lipid that comprises free amino group, comprise fat, wax and sterol, the group that it selects free vegetable oil, fish oil and animal tallow and composition thereof to form; (b) at least one carbohydrate that comprises reduced sugar group, the group that described carbohydrate selects free monose, disaccharides, trisaccharide, oligosaccharides, maltodextrin, resistant maltodextrin, starch, derivative material, glucose syrup, glucose syrup solids and the honey of starch to form;
Wherein, described at least one protein and/or at least one lipid are reactive to described at least one carbohydrate, make when described mixture heating a period of time not being solidified to allow abundant saccharification occurs and when dry, described composition is suitable for encapsulation agent rehydrated of oxysensible oil and oxysensible oil-soluble bioactivator and forms.
2. composition according to claim 1, wherein, described composition is dry by spraying, drum drying, freeze drying or film infiltration are dried.
3. composition according to claim 2, wherein, described composition is dried by spraying.
4. according to the composition described in any one in claims 1 to 3, wherein, described at least one carbohydrate has glucose equivalent (DE) value of the merging of 10-100%.
5. according to the composition described in any one in claim 1 to 4, wherein, the ratio of protein and carbohydrate is 1:10 to 10:1.
6. according to the composition described in any one in claim 1 to 5, wherein, described at least one protein is casein, whey or soy protein isolate.
7. according to the composition described in any one in claim 1 to 6, wherein, described at least one carbohydrate is the monose that is selected from glucose or fructose.
8. according to the composition described in any one in claim 1 to 6, wherein, described at least one carbohydrate is the disaccharides that is selected from maltose or lactose.
9. a composition that comprises the product of at least one additive and following mixture, comprises:
(a) aqueous solution of following material: at least one protein that comprises free amino group, the group that described protein selects free casein, soybean, whey, gelatin, egg, albumin, forms from albumen and the hydrolysed form thereof of marine alga, yeast or originated from fungus, and/or at least one lipid that comprises free amino group, comprise fat, wax and sterol, the group that it selects free vegetable oil, fish oil and animal tallow and composition thereof to form; (b) at least one carbohydrate that comprises reduced sugar group, the group that described carbohydrate selects free monose, disaccharides, trisaccharide, oligosaccharides, maltodextrin, resistant maltodextrin, starch, derivative material, glucose syrup, glucose syrup solids and the honey of starch to form; Wherein, described at least one protein and/or at least one lipid are reactive to described at least one carbohydrate, make when before or after mixing with at least one additive, described mixture heating a period of time not being solidified to allow abundant saccharification occurs and when dry, described composition is suitable for encapsulation agent rehydrated of oxysensible oil and oxysensible oil-soluble bioactivator and forms.
10. composition according to claim 9, wherein, the group that described at least one additive selects free surfactant, wetting agent, emulsifying agent, defoamer and dispersant to form.
11. compositions according to claim 10, wherein, described at least one additive selects the monoglyceride of free dioctyl sodium sulphosuccinate, aliphatic acid and diglyceride, lecithin, modified starch, xanthans, the group that sad and dimethyl silicone polymer forms.
12. 1 kinds are used to form according to the method for the composition described in any one in claim 1 to 11, comprise the following steps:
(a) aqueous mixture of at least one protein that preparation comprises free amino group or lipid and at least one carbohydrate that comprises reduced sugar group;
(b) described mixture heating a period of time is not solidified to allow abundant saccharification to occur; And
(c) described aqueous mixture is dried to provide the composition of the rehydrated and formation of the encapsulation agent that is suitable for oxysensible oil and oxysensible oil-soluble bioactivator.
13. methods according to claim 12, wherein, at least one additive adds afterwards and in step (c) before in step (b).
14. methods according to claim 12, wherein, at least one additive is afterwards by using being dry mixed or spraying and adding of lipid carrier in step (c).
15. according to the method described in claim 13 or 14, wherein, and the group that described at least one additive selects free surfactant, wetting agent, emulsifying agent, defoamer and dispersant to form.
16. methods according to claim 15, wherein, described at least one additive selects the monoglyceride of free dioctyl sodium sulphosuccinate, aliphatic acid and diglyceride, lecithin, modified starch, xanthans, the group that sad and dimethyl silicone polymer forms.
17. according to claim 12 to the method described in any one in 16, and wherein, described aqueous mixture is dry by spraying, drum drying, freeze drying or film infiltration are dried.
18. methods according to claim 17, wherein, described aqueous mixture is dried by spraying.
19. according to claim 12 to the method described in any one in 18, and wherein, the protein component in described aqueous mixture exists with 1 to 30% scope by weight, and described carbohydrate ingredient exists with 1 to 60% scope.
20. according to claim 12 to the method described in any one in 19, and wherein, the described mixture in step (b) heats in the scope of 60-160 ℃.
21. 1 kinds of methods that are used to form the emulsion of sealing oxysensible oil or oxysensible oil-soluble bioactivator, comprise the following steps:
(a) by rehydrated in water according to the composition described in any one in claim 1 to 11, described composition comprises at least one additive alternatively; With
(b) by described water with the oil phase homogenization that comprises oxysensible oil or oxysensible oil-soluble bioactivator to obtain emulsion.
22. methods according to claim 21 wherein, were dispersed in described at least one additive in described water before described composition is rehydrated.
23. 1 kinds of methods that are used to form the powder of sealing oxysensible oil or oxysensible oil-soluble bioactivator, comprise the following steps:
(a) by rehydrated in water according to the composition described in any one in claim 1 to 11, described composition comprises at least one additive alternatively; With
(b) by described water with the oil phase homogenization that comprises oxysensible oil or oxysensible oil-soluble bioactivator to obtain emulsion; And
(c) described emulsion is dried to the powder of sealing to form.
24. methods according to claim 23, wherein, before described composition is rehydrated, are dispersed in described at least one additive in described water.
25. according to the method described in any one in claim 21 to 24, wherein, after described composition is rehydrated and before by described water and described oil phase homogenization, adds at least one carrier.
26. methods according to claim 25, wherein, the group that described carrier selects free casein, lactalbumin, starch, maltodextrin and oligosaccharides to form.
27. according to the method described in any one in claim 21 to 26, wherein, and the group that described at least one additive selects free surfactant, wetting agent, emulsifying agent, defoamer and dispersant to form.
28. methods according to claim 27, wherein, described additive selects the monoglyceride of free dioctyl sodium sulphosuccinate, aliphatic acid and diglyceride, lecithin, modified starch, xanthans, the group that sad and dimethyl silicone polymer forms.
29. according to the method described in claim 23 or 24, and wherein, described emulsion is dry by spraying, drum drying, freeze drying or film infiltration are dried.
30. methods according to claim 29, wherein, described emulsion is dried by spraying.
31. according to the method described in any one in claim 21 to 30, and wherein, described oil phase is selected from oil, fat of dairy product, algae oil, the fungal oil of long-chain polyunsaturated fatty acid, marine source; The oil of plant derivation and oil-soluble composition, comprise vitamin A [retinol], vitamin D [calciferol], vitamin E, tocopherol, fertility triol, vitamin K [benzoquinones] and beta carotene [provitamin A].
32. according to claim 12 to the method described in any one in 20, and wherein, described composition exists with the amount of 1-99wt%.
33. according to claim 12 to the method described in any one in 20, and wherein, described composition exists with the amount of 20-80wt%.
34. according to the method described in any one in claim 21 to 31, and wherein, described oil phase heap(ed) capacity is 10-70%.
35. according to the method described in any one in claim 21 to 31, and wherein, described oil phase heap(ed) capacity is 25-60%.
36. according to the method described in any one in claim 21 to 31, and wherein, described composition exists in the scope with dry weight 10-80%.
37. according to the method described in any one in claim 21 to 31, and wherein, described composition exists in the scope with dry weight 10-50%.
38. according to the method described in any one in claim 21 to 31, and wherein, described composition exists in the scope with dry weight 40-50%.
39. according to the method described in any one in claim 21 to 38, and wherein, described homogenization step is carried out with 350/100 bar.
40. according to the method described in any one in claim 21 to 39, and wherein, the granular size of disperseing in described emulsion is 1 to 10 micron.
41. according to the method described in any one in claim 21 to 39, and wherein, the granular size of disperseing in described emulsion is 1 to 5 micron.
42. according to the method described in any one in claim 21 to 39, and wherein, the granular size of disperseing in described emulsion is for being less than 1 micron.
43. according to the method described in any one in claim 21 to 39, and wherein, the granular size of disperseing in described emulsion is approximately 0.3 micron.
44. application in the encapsulation agent of the oxysensible oil of preparation and oxysensible oil-soluble bioactivator according to the composition described in any one in claim 1-11, wherein, described encapsulation agent is for food, food composition, functional food, enriching substance, medicine, medical food, the baby food that comprises formula food and animal feed.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2011904676A AU2011904676A0 (en) | 2011-11-10 | Encapsulation of Food Ingredients Supplements and Pharmaceuticals | |
| AU2011904676 | 2011-11-10 | ||
| PCT/AU2012/001393 WO2013067603A1 (en) | 2011-11-10 | 2012-11-12 | Encapsulation of food ingredients supplements and pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103987279A true CN103987279A (en) | 2014-08-13 |
Family
ID=48288388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280055000.0A Pending CN103987279A (en) | 2011-11-10 | 2012-11-12 | Encapsulation of food ingredients supplements and pharmaceuticals |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN103987279A (en) |
| AU (1) | AU2012280935A1 (en) |
| WO (1) | WO2013067603A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112638167A (en) * | 2018-09-04 | 2021-04-09 | 罗盖特公司 | Stable compositions comprising edible oils and their use in food products |
| CN113331418A (en) * | 2021-06-07 | 2021-09-03 | 江苏海王健康生物科技有限公司 | Nutrient supplement for enhancing immune function and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2015036043A1 (en) | 2013-09-13 | 2015-03-19 | N.V. Nutricia | Improved process for preparing infant formula using a rotary atomizer |
| WO2015036046A1 (en) * | 2013-09-13 | 2015-03-19 | N.V. Nutricia | Improved process for preparing infant formula using a static mixer |
| CN103932183A (en) * | 2014-04-09 | 2014-07-23 | 吉林大学 | Forest frog oil polypeptide microencapsulation and preparation method thereof |
| ES2500891B1 (en) * | 2014-06-24 | 2015-06-01 | Alfredo GARRIGOSA MENDOZA | Manufacturing procedure of a basic nutritional compound for preparing food and nutritional compound obtained |
| US20210093578A1 (en) * | 2017-04-27 | 2021-04-01 | Clover Corporation Limited | Encapsulated nutritional and pharmaceutical compositions |
| WO2021195534A1 (en) | 2020-03-26 | 2021-09-30 | Cargill, Incorporated | Microprocessing for preparing modified protein |
| WO2023076425A1 (en) * | 2021-10-26 | 2023-05-04 | Ecs Brands, Ltd. | Albumin protein for use as an emulsifier and drug carrier |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2013067603A1 (en) | 2013-05-16 |
| AU2012280935A1 (en) | 2013-05-30 |
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Application publication date: 20140813 |