CN103974712A - 治疗阿尔茨海默氏症、亨廷顿氏症、孤独症和其他障碍的方法 - Google Patents

治疗阿尔茨海默氏症、亨廷顿氏症、孤独症和其他障碍的方法 Download PDF

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Publication number
CN103974712A
CN103974712A CN201280027349.3A CN201280027349A CN103974712A CN 103974712 A CN103974712 A CN 103974712A CN 201280027349 A CN201280027349 A CN 201280027349A CN 103974712 A CN103974712 A CN 103974712A
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alkyl
phenyl
alkenyl
optionally substituted
halogen
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J·莫斯卡尔
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NORTHWEST UNIVERSITY
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201280027349.3A 2011-04-27 2012-04-27 治疗阿尔茨海默氏症、亨廷顿氏症、孤独症和其他障碍的方法 Pending CN103974712A (zh)

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CN201711451914.XA CN108283712A (zh) 2011-04-27 2012-04-27 治疗阿尔茨海默氏症、亨廷顿氏症、孤独症和其他障碍的方法

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US201161479593P 2011-04-27 2011-04-27
US61/479,593 2011-04-27
US201161527744P 2011-08-26 2011-08-26
US61/527,744 2011-08-26
PCT/US2012/035547 WO2012149389A2 (en) 2011-04-27 2012-04-27 Methods of treating alzheimer's disease, huntington's disease, autism, or other disorders

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CN201711451914.XA Pending CN108283712A (zh) 2011-04-27 2012-04-27 治疗阿尔茨海默氏症、亨廷顿氏症、孤独症和其他障碍的方法

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US (4) US20140107037A1 (enExample)
EP (2) EP3679931A3 (enExample)
JP (1) JP6035326B2 (enExample)
KR (5) KR20180095096A (enExample)
CN (2) CN103974712A (enExample)
AU (1) AU2012249397B2 (enExample)
BR (1) BR112013027554A2 (enExample)
CA (1) CA2834286A1 (enExample)
EA (2) EA201790653A1 (enExample)
HK (1) HK1258231A1 (enExample)
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Cited By (15)

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US9504670B2 (en) 2013-01-29 2016-11-29 Aptinyx, Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9512133B2 (en) 2008-09-18 2016-12-06 Northwestern University NMDA receptor modulators and uses thereof
US9708335B2 (en) 2013-01-29 2017-07-18 Apytinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9738650B2 (en) 2013-01-29 2017-08-22 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9758525B2 (en) 2013-01-29 2017-09-12 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9828384B2 (en) 2013-01-29 2017-11-28 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9925169B2 (en) 2016-05-19 2018-03-27 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9932347B2 (en) 2016-05-19 2018-04-03 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10150769B2 (en) 2016-08-01 2018-12-11 Aptinyx Inc. Spiro-lactam NMDA modulators and methods of using same
US10918637B2 (en) 2016-08-01 2021-02-16 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10961189B2 (en) 2016-08-01 2021-03-30 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US11028095B2 (en) 2016-08-01 2021-06-08 Aptinyx Inc. Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof
US11299495B2 (en) 2016-08-01 2022-04-12 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US11578072B2 (en) 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

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KR101692275B1 (ko) 2010-02-11 2017-01-04 노오쓰웨스턴 유니버시티 ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도
RU2566821C2 (ru) 2010-02-11 2015-10-27 Нортвестерн Юниверсити Модулятор nmda-рецептора со стабилизированной вторичной структурой и его применение
MX378668B (es) * 2013-10-28 2025-03-10 Naurex Inc Profarmacos y moduladores de receptores nmda, sales y usos de estos.
US20160345855A1 (en) * 2013-12-13 2016-12-01 Northwestern University Methods of treating brain disorders or identifying biomarkers related thereto
CN105327349A (zh) * 2014-06-18 2016-02-17 上海翰森生物医药科技有限公司 Nmda受体拮抗剂的医药用途及其药物组合物
JP6688748B2 (ja) * 2014-06-23 2020-04-28 ノースウェスタン ユニバーシティ 片頭痛の治療または改善方法
EP3362080A1 (en) * 2015-10-16 2018-08-22 Northwestern University Pharmaceutical combination of an atypical antipsychotic and an nmda modulator for the treatment of schizophrenia,bipolar disorder, cognitive impairment and major depressive disorder
KR102415692B1 (ko) 2020-09-01 2022-07-05 건국대학교 글로컬산학협력단 시냅스 불균형 조절에 의한 발달장애 예방, 개선 또는 치료용 조성물

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Cited By (36)

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US9802946B2 (en) 2008-09-18 2017-10-31 Northwestern University NMDA receptor modulators and uses thereof
US9512133B2 (en) 2008-09-18 2016-12-06 Northwestern University NMDA receptor modulators and uses thereof
US10906913B2 (en) 2008-09-18 2021-02-02 Northwestern University NMDA receptor modulators and uses thereof
US9828384B2 (en) 2013-01-29 2017-11-28 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US12167998B2 (en) 2013-01-29 2024-12-17 Tenacia Biotechnology (Hong Kong) Co., Limited Spiro-lactam NMDA receptor modulators and uses thereof
US9738650B2 (en) 2013-01-29 2017-08-22 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9758525B2 (en) 2013-01-29 2017-09-12 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9579304B2 (en) 2013-01-29 2017-02-28 Aptinyx, Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10441572B2 (en) 2013-01-29 2019-10-15 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9504670B2 (en) 2013-01-29 2016-11-29 Aptinyx, Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9708335B2 (en) 2013-01-29 2017-07-18 Apytinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10052308B2 (en) 2013-01-29 2018-08-21 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US11077094B2 (en) 2013-01-29 2021-08-03 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9512134B2 (en) 2013-01-29 2016-12-06 Aptinyx, Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10441571B2 (en) 2013-01-29 2019-10-15 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10253032B2 (en) 2013-01-29 2019-04-09 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10273239B2 (en) 2013-01-29 2019-04-30 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10316041B2 (en) 2013-01-29 2019-06-11 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9925169B2 (en) 2016-05-19 2018-03-27 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10196401B2 (en) 2016-05-19 2019-02-05 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10195179B2 (en) 2016-05-19 2019-02-05 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US9932347B2 (en) 2016-05-19 2018-04-03 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US11376250B2 (en) 2016-08-01 2022-07-05 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US11512051B2 (en) 2016-08-01 2022-11-29 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10150769B2 (en) 2016-08-01 2018-12-11 Aptinyx Inc. Spiro-lactam NMDA modulators and methods of using same
US11299495B2 (en) 2016-08-01 2022-04-12 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US11370790B2 (en) 2016-08-01 2022-06-28 Aptinyx Inc. Spiro-lactam NMDA modulators and methods of using same
US10961189B2 (en) 2016-08-01 2021-03-30 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US11427585B2 (en) 2016-08-01 2022-08-30 Aptinyx Inc. Spiro-lactam NMDA modulators and methods of using same
US11028095B2 (en) 2016-08-01 2021-06-08 Aptinyx Inc. Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof
US11530223B2 (en) 2016-08-01 2022-12-20 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US10918637B2 (en) 2016-08-01 2021-02-16 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US12157736B2 (en) 2016-08-01 2024-12-03 Tenacia Biotechnology (Hong Kong) Co., Limited Spiro-lactam NMDA modulators and methods of using same
US12084444B2 (en) 2016-08-01 2024-09-10 Tenacia Biotechnology (Hong Kong) Co., Limited Spiro-lactam NMDA modulators and methods of using same
US11578072B2 (en) 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

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BR112013027554A2 (pt) 2016-09-06
AU2012249397A1 (en) 2013-11-07
KR20190037359A (ko) 2019-04-05
HK1258231A1 (zh) 2019-11-08
JP2014520072A (ja) 2014-08-21
JP6035326B2 (ja) 2016-11-30
WO2012149389A3 (en) 2014-05-08
SG10202010665YA (en) 2020-11-27
EP3679931A2 (en) 2020-07-15
CA2834286A1 (en) 2012-11-01
KR20140043078A (ko) 2014-04-08
EP2701721A2 (en) 2014-03-05
EP2701721A4 (en) 2015-12-16
KR20180095096A (ko) 2018-08-24
CN108283712A (zh) 2018-07-17
US20170049845A1 (en) 2017-02-23
MX2013012526A (es) 2014-04-16
EA029999B1 (ru) 2018-06-29
EP3679931A3 (en) 2020-10-14
SG194230A1 (en) 2013-12-30
KR20200043534A (ko) 2020-04-27
AU2012249397B2 (en) 2017-03-30
EA201391581A1 (ru) 2014-05-30
US20210169964A1 (en) 2021-06-10
MX357761B (es) 2018-07-23
WO2012149389A2 (en) 2012-11-01
US20140107037A1 (en) 2014-04-17
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US20190209642A1 (en) 2019-07-11
EA201790653A1 (ru) 2017-07-31

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