CN103966899B - A kind of filmogen and compound method and the band film test paper by this filmogen film forming - Google Patents
A kind of filmogen and compound method and the band film test paper by this filmogen film forming Download PDFInfo
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- 238000012360 testing method Methods 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title claims abstract description 9
- 150000001875 compounds Chemical class 0.000 title claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims abstract description 36
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 17
- 239000001856 Ethyl cellulose Substances 0.000 claims abstract description 17
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims abstract description 17
- 108010010803 Gelatin Proteins 0.000 claims abstract description 17
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 17
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 17
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims abstract description 17
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 17
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 17
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 17
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 17
- 229920002301 cellulose acetate Polymers 0.000 claims abstract description 17
- 229920001249 ethyl cellulose Polymers 0.000 claims abstract description 17
- 235000019325 ethyl cellulose Nutrition 0.000 claims abstract description 17
- 229920000159 gelatin Polymers 0.000 claims abstract description 17
- 239000008273 gelatin Substances 0.000 claims abstract description 17
- 235000019322 gelatine Nutrition 0.000 claims abstract description 17
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 17
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 17
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 17
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 17
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 17
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 17
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 17
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229920000609 methyl cellulose Polymers 0.000 claims abstract description 17
- 239000001923 methylcellulose Substances 0.000 claims abstract description 17
- 235000010981 methylcellulose Nutrition 0.000 claims abstract description 17
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims abstract description 17
- 239000004926 polymethyl methacrylate Substances 0.000 claims abstract description 17
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 17
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 17
- 229920002554 vinyl polymer Polymers 0.000 claims abstract description 17
- -1 polyethylene Polymers 0.000 claims abstract description 13
- 239000004698 Polyethylene Substances 0.000 claims abstract description 12
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 12
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 12
- 229920000573 polyethylene Polymers 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000006116 polymerization reaction Methods 0.000 claims description 70
- 239000011347 resin Substances 0.000 claims description 30
- 229920005989 resin Polymers 0.000 claims description 30
- 239000012528 membrane Substances 0.000 claims description 23
- 238000002360 preparation method Methods 0.000 claims description 10
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 230000003068 static effect Effects 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 abstract description 22
- 239000008280 blood Substances 0.000 abstract description 22
- 210000003743 erythrocyte Anatomy 0.000 abstract description 9
- 239000011148 porous material Substances 0.000 abstract description 4
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 16
- 239000008103 glucose Substances 0.000 description 16
- 238000001914 filtration Methods 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
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- Manufacture Of Macromolecular Shaped Articles (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A kind of filmogen, comprises raw material: polyethylene, polyacrylic acid, polyvinyl formal, polymethyl methacrylate, gelatin, PVP, polyvinyl alcohol, methylcellulose, carboxymethyl cellulose, ethyl cellulose, hydroxyethylcellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, cellulose acetate, alkylpolyoxyethylene, ethanol, toluene and acetone; Its compound method is for mix step by step, obtain the filmogen of energy homogeneous film formation, use this filmogen can obtain uniform pore diameter on test paper body, the transparent porous film be evenly distributed, red blood cell in blood, not by fenestra, can carry out accurate interpretation after wiping, shake.
Description
Technical field
The present invention relates to a kind of test paper, specifically, relate to a kind of filmogen and compound method thereof and the band film test paper by this filmogen film forming.
Background technology
Full blood glucose test paper is respectively used to the quick detection of glucose in blood, but when detecting, the red blood cell in blood can be adsorbed on test paper and test paper is taken on a red color, interference sentence read result; People expected that adding a skim on test paper surface intercepted the red blood cell in blood and test paper afterwards, but glucose also can intercept by common film intercepting erythrocytic while, and enzyme reaction can not be carried out, and test paper can not effectively detect;
Researcher expected afterwards, a kind of perforated membrane with certain pore size size can be obtained, the red blood cell in blood is made not enter test paper by film, the Small molecular of glucose is then by this film, the research of existing related fields at present, but be only be applied to medicine field, the application in test paper, the application particularly on full blood glucose test paper rarely has report;
Full blood glucose test paper forms perforated membrane, need to ensure that the pore size control of film is in suitable scope, the enzyme agent of test paper absorption itself is not destroyed when will ensure film forming yet, auxiliary agent and auxiliary material etc., surface after also will ensureing film forming be easy to wiping and not disturbance reponse colour developing, simultaneously, current test paper filmogen is when film forming, the film formed in enzyme agent part is finer and close, the dense film aperture of this part is very little, almost can not through glucose, testing result can be had a strong impact on, how to form a kind of uniform perforated membrane on full blood glucose test paper surface, then the main points that researcher of the present invention considers.
Summary of the invention
For solving above technical problem, one of the object of the invention is to provide a kind of filmogen that can form even porous film on full blood glucose test paper surface.
Two of the object of the invention is to provide a kind of compound method that can form the filmogen of even porous film.
Three of the object of the invention is the band film test paper providing a kind of filmogen film forming.
Technical scheme is as follows:
(1), one of the object of the invention is achieved in that
A kind of filmogen, its key is to be mixed by the raw material of following mass fraction: polyethylene 0.5 ~ 1.2 part, polyacrylic acid 0.3 ~ 0.8 part, polyvinyl formal 0.15 ~ 0.3 part, polymethyl methacrylate 0.3 ~ 0.7 part, gelatin 0..25 ~ 0.3 part, PVP 0.2 ~ 0.5 part, polyvinyl alcohol 0.2 ~ 0.4 part, methylcellulose 0.1 ~ 0.2 part, carboxymethyl cellulose 0.05 ~ 0.08 part, ethyl cellulose 1.1 ~ 2.5 parts, hydroxyethylcellulose 0.08 ~ 0.1 part, hydroxypropyl methylcellulose 0.3 ~ 0.35 part, hydroxypropyl cellulose 0.01 ~ 0.02 part, cellulose acetate 0.3 ~ 0.5 part, alkylpolyoxyethylene 7 ~ 9 parts, ethanol 45 ~ 52 parts, toluene 55 ~ 70 parts, 18 ~ 25 parts, acetone.
Preferably, the above-mentioned poly degree of polymerization is 2500 ~ 5000, the polyacrylic degree of polymerization is 1800 ~ 2000, the degree of polymerization of polyvinyl formal is 2000 ~ 2500, the degree of polymerization of polymethyl methacrylate is 2000 ~ 2200, the degree of polymerization of gelatin is 6500 ~ 6800, the degree of polymerization of PVP is 3700 ~ 3900, the degree of polymerization of polyvinyl alcohol is 3500 ~ 5000, the degree of polymerization of methylcellulose is 8000 ~ 9500, the degree of polymerization of carboxymethyl cellulose is 7500 ~ 9000, the degree of polymerization of ethyl cellulose is 6800 ~ 7520, the degree of polymerization of hydroxyethylcellulose is 5500 ~ 8000, the degree of polymerization of hydroxypropyl methylcellulose is 5000 ~ 10000, the degree of polymerization of hydroxypropyl cellulose is 10000 ~ 15000, the degree of polymerization of cellulose acetate is 700 ~ 1000.
As further preferred version, a kind of filmogen, its main points are to be mixed by the raw material of following mass fraction: polyethylene 0.8 part, polyacrylic acid 0.45 part, polyvinyl formal 0.22 part, polymethyl methacrylate 0.45 part, 0.28 part, gelatin, PVP 0.44 part, polyvinyl alcohol 0.38 part, methylcellulose 0.17 part, carboxymethyl cellulose 0.06 part, ethyl cellulose 1.8 parts, hydroxyethylcellulose 0.09 part, hydroxypropyl methylcellulose 0.33 part, hydroxypropyl cellulose 0.016 part, cellulose acetate 0.45 part, alkylpolyoxyethylene 8.5 parts, ethanol 50 parts, toluene 65 parts, 22 parts, acetone.
As further preferred version, above-mentioned ethanol is the hydrous ethanol of volume fraction 80% ~ 87%.
(2), two of the object of the invention be achieved in that
A compound method for filmogen, its key is to comprise the following steps:
Sp1, preparation the first main resin solution
According to the mass fraction ratio of 0.5 ~ 1.2:0.3 ~ 0.8:0.15 ~ 0.3:0.3 ~ 0.7:0.2 ~ 0.5:55 ~ 70, described polyethylene, polyacrylic acid, polyvinyl formal, polymethyl methacrylate, PVP and toluene are mixed, obtain described first main resin solution;
Sp2, preparation the second main resin solution
Described methylcellulose, carboxymethyl cellulose, ethyl cellulose, hydroxyethylcellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, cellulose acetate, ethanol and the acetone mass fraction ratio according to 0.1 ~ 0.2:0.05 ~ 0.08:1.1 ~ 2.5:0.08 ~ 0.1:0.3 ~ 0.35:0.01 ~ 0.02:0.3 ~ 0.5:45 ~ 52:18 ~ 25 is mixed, obtains described second main resin solution;
Sp3, be mixed with membrane material
Described first main resin solution and the second main resin solution are mixed, described gelatin and polyvinyl alcohol is added successively again in the mass fraction ratio of 0..25 ~ 0.3:0.2 ~ 0.4, mix, static 30min, finally add the alkylpolyoxyethylene of 7 ~ 9 parts of mass fractions, be uniformly mixed, obtain described filmogen.(3), three of the object of the invention be achieved in that
A kind of band film test paper of filmogen film forming, its key is: comprise test paper body, filmogen is had at the outer surface of this test paper body, this filmogen forms perforated membrane, on this perforated membrane, the aperture of micropore is 25 ~ 100nm, the porosity of this perforated membrane is 75% ~ 85%, and the thickness of this perforated membrane is 0.8 ~ 2um.Adopt this design, the red blood cell in blood is not by perforated membrane, and the glucose in blood enters after test paper body and enzyme agent react, and the red blood cell wiping porous film surface can carry out accurate interpretation to result.
Beneficial effect: adopt the present invention to prepare the filmogen obtained, transparent, equally distributed perforated membrane can be obtained on full blood glucose test paper, the uniform pore diameter of perforated membrane, red blood cell in blood is not by fenestra, interpretation can not be disturbed, use the band film full blood glucose test paper that the present invention obtains, blood in test paper surface aggegation, can not can carry out accurate interpretation after wiping, shake.
Accompanying drawing explanation
Fig. 1 is the flow chart of the compound method of a kind of filmogen of the present invention;
Fig. 2 is the structural representation of the band film test paper of a kind of filmogen film forming of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1:
A kind of filmogen I, is mixed by the raw material of following mass fraction: polyethylene 0.5 part, polyacrylic acid 0.3 part, polyvinyl formal 0.15 part, polymethyl methacrylate 0.3 part, gelatin 0..25 part, PVP 0.2 part, polyvinyl alcohol 0.2, methylcellulose 0.2 part, carboxymethyl cellulose 0.08 part, ethyl cellulose 2.5 parts, hydroxyethylcellulose 0.1 part, hydroxypropyl methylcellulose 0.35 part, hydroxypropyl cellulose 0.02 part, cellulose acetate 0.5 part, alkylpolyoxyethylene 9 parts, ethanol 52 parts, toluene 70 parts, 25 parts, acetone;
The described poly degree of polymerization is 2500, the polyacrylic degree of polymerization is 1800, the degree of polymerization of polyvinyl formal is 2000, the degree of polymerization of polymethyl methacrylate is 2000, the degree of polymerization of gelatin is 6500, the degree of polymerization of PVP is 3900, the degree of polymerization of polyvinyl alcohol is 5000, the degree of polymerization of methylcellulose is 9500, the degree of polymerization of carboxymethyl cellulose is 9000, the degree of polymerization of ethyl cellulose is 7520, the degree of polymerization of hydroxyethylcellulose is 8000, the degree of polymerization of hydroxypropyl methylcellulose is 5000, the degree of polymerization of hydroxypropyl cellulose is 10000, the degree of polymerization of cellulose acetate is 700, described ethanol is the hydrous ethanol of volume fraction 80%.
Described filmogen I is prepared by following steps and is obtained:
Sp1, preparation the first main resin solution
Described polyethylene, polyacrylic acid, polyvinyl formal, polymethyl methacrylate, PVP and toluene are mixed by both certainty ratios, obtains described first main resin solution;
Sp2, preparation the second main resin solution
Described methylcellulose, carboxymethyl cellulose, ethyl cellulose, hydroxyethylcellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, cellulose acetate, ethanol and acetone are mixed according to set mass fraction ratio, obtains described second main resin solution;
Sp3, be mixed with membrane material
Described first main resin solution and the second main resin solution are mixed, then adds gelatin and polyvinyl alcohol successively by set mass fraction, mix, static 30min, finally add the alkylpolyoxyethylene of 9 parts of mass fractions, be uniformly mixed, obtain described filmogen I.
Embodiment 2:
A kind of filmogen II, is mixed by the raw material of following mass fraction: polyethylene 1.2 parts, polyacrylic acid 0.8 part, polyvinyl formal 0.3 part, polymethyl methacrylate 0.7 part, 0.3 part, gelatin, PVP 0.5 part, polyvinyl alcohol 0.4 part, methylcellulose 0.1 part, carboxymethyl cellulose 0.05 part, ethyl cellulose 1.1 parts, hydroxyethylcellulose 0.08 part, hydroxypropyl methylcellulose 0.3 part, hydroxypropyl cellulose 0.01 part, cellulose acetate 0.3 part, alkylpolyoxyethylene 7 parts, ethanol 45 parts, toluene 55 parts, 18 parts, acetone;
The described poly degree of polymerization is 5000, the polyacrylic degree of polymerization is 2000, the degree of polymerization of polyvinyl formal is 2500, the degree of polymerization of polymethyl methacrylate is 2200, the degree of polymerization of gelatin is 6800, the degree of polymerization of PVP is 3700, the degree of polymerization of polyvinyl alcohol is 3500, the degree of polymerization of methylcellulose is 8000, the degree of polymerization of carboxymethyl cellulose is 7500, the degree of polymerization of ethyl cellulose is 6800, the degree of polymerization of hydroxyethylcellulose is 5500, the degree of polymerization of hydroxypropyl methylcellulose is 10000, the degree of polymerization of hydroxypropyl cellulose is 15000, the degree of polymerization of cellulose acetate is 1000, described ethanol is the hydrous ethanol of volume fraction 87%.
Described filmogen II is prepared by following steps and is obtained:
Sp1, preparation the first main resin solution
Described polyethylene, polyacrylic acid, polyvinyl formal, polymethyl methacrylate, PVP and toluene are mixed by both certainty ratios, obtains described first main resin solution;
Sp2, preparation the second main resin solution
Described methylcellulose, carboxymethyl cellulose, ethyl cellulose, hydroxyethylcellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, cellulose acetate, ethanol and acetone are mixed according to set mass fraction ratio, obtains described second main resin solution;
Sp3, be mixed with membrane material
Described first main resin solution and the second main resin solution are mixed, then adds gelatin and polyvinyl alcohol successively by set mass fraction, mix, static 30min, finally add the alkylpolyoxyethylene of 7 parts of mass fractions, be uniformly mixed, obtain described filmogen II.
Embodiment 3:
A kind of filmogen III, mixed by the raw material of following mass fraction: polyethylene 0.8 part, polyacrylic acid 0.45 part, polyvinyl formal 0.22 part, polymethyl methacrylate 0.45 part, 0.28 part, gelatin, PVP 0.44 part, polyvinyl alcohol 0.38 part, methylcellulose 0.17 part, carboxymethyl cellulose 0.06 part, ethyl cellulose 1.8 parts, hydroxyethylcellulose 0.09 part, hydroxypropyl methylcellulose 0.33 part, hydroxypropyl cellulose 0.016 part, cellulose acetate 0.45 part, alkylpolyoxyethylene 8.5 parts, ethanol 50 parts, toluene 65 parts, 22 parts, acetone,
The described poly degree of polymerization is 2800, the polyacrylic degree of polymerization is 1900, the degree of polymerization of polyvinyl formal is 2300, the degree of polymerization of polymethyl methacrylate is 2150, the degree of polymerization of gelatin is 6680, the degree of polymerization of PVP is 3800, the degree of polymerization of polyvinyl alcohol is 4700, the degree of polymerization of methylcellulose is 8700, the degree of polymerization of carboxymethyl cellulose is 8000, the degree of polymerization of ethyl cellulose is 7300, the degree of polymerization of hydroxyethylcellulose is 5500 ~ 8000, the degree of polymerization of hydroxypropyl methylcellulose is 5000 ~ 10000, the degree of polymerization of hydroxypropyl cellulose is 10000 ~ 15000, the degree of polymerization of cellulose acetate is 700 ~ 1000, described ethanol is the hydrous ethanol of volume fraction 87%.
Described filmogen III is prepared by following steps and is obtained:
Sp1, preparation the first main resin solution
Described polyethylene, polyacrylic acid, polyvinyl formal, polymethyl methacrylate, PVP and toluene are mixed by both certainty ratios, obtains described first main resin solution;
Sp2, preparation the second main resin solution
Described methylcellulose, carboxymethyl cellulose, ethyl cellulose, hydroxyethylcellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, cellulose acetate, ethanol and acetone are mixed according to set mass fraction ratio, obtains described second main resin solution;
Sp3, be mixed with membrane material
Described first main resin solution and the second main resin solution are mixed, then adds gelatin and polyvinyl alcohol successively by set mass fraction, mix, static 30min, finally add the alkylpolyoxyethylene of 8.5 parts of mass fractions, be uniformly mixed, obtain described filmogen III.
Embodiment 4:
A kind of band film test paper of filmogen film forming, its key is: comprise test paper body 1, filmogen is had at the outer surface of this test paper body 1, this filmogen forms perforated membrane 2, on this perforated membrane 2, the aperture of micropore is 25 ~ 100nm, the porosity of this perforated membrane 2 is 75% ~ 85%, and the thickness of this perforated membrane 2 is 0.8 ~ 2um.
Below in conjunction with test example, the invention will be further described.
The filmogen using the embodiment of the present invention 1 to provide to embodiment 3 is the surperficial masking of fast grade filter paper of 80 ~ 120um in aperture, film-forming method is dry for first flooding again, obtain respectively being with film filter paper I, band film filter paper II and band film filter paper III, re-use band film filter paper I, band film filter paper II, band film filter paper III and fast grade filter paper filtering whole blood respectively, measure before filtering and use band film filter paper I, band film filter paper II, after band film filter paper III and fast grade filter paper filter respectively, red blood cell in blood, leucocyte, blood platelet, the content of hemoglobin and glucose, measurement result is as shown in table 1, observe the surface state of band film filter paper I after filtering, band film filter paper II, band film filter paper III and fast grade filter paper.
Composition measurement before and after table 1, Whole Blood Filtration
As can be seen from Table 1, can intercept red blood cell, leucocyte, blood platelet and the hemoglobin in whole blood completely with film filter paper I, band film filter paper II and band film filter paper III, glucose then can free in and out on band film filter paper I, band film filter paper II and band film filter paper III.Observe and find, after having filtered, fast grade filter paper takes on a red color, and does not fade after shake; After filtration completes, the surface of band film filter paper I, band film filter paper II and band film filter paper III is distributed with red drop, and all there is Bai Xin inside, after shake, and the equal landing of surperficial red drop.
Use band film filter paper I, band film filter paper II and be with film filter paper III to obtain respectively the band film test paper I, band film test paper II and the band film test paper III that detect for full blood glucose, re-use band film test paper I, band film test paper II and band film test paper III and carry out full blood glucose detection, testing result shows, develop the color clear, obvious, can accurate interpretation be carried out.
Finally it should be noted that; foregoing description is only the preferred embodiment of invention; those of ordinary skill in the art is under enlightenment of the present invention; under the prerequisite without prejudice to present inventive concept and claim; can make like multiple types and representing, such conversion all falls within protection scope of the present invention.
Claims (4)
1. a filmogen, it is characterized in that being mixed by the raw material of following mass fraction: polyethylene 0.5 ~ 1.2 part, polyacrylic acid 0.3 ~ 0.8 part, polyvinyl formal 0.15 ~ 0.3 part, polymethyl methacrylate 0.3 ~ 0.7 part, 0.25 ~ 0.3 part, gelatin, PVP 0.2 ~ 0.5 part, polyvinyl alcohol 0.2 ~ 0.4 part, methylcellulose 0.1 ~ 0.2 part, carboxymethyl cellulose 0.05 ~ 0.08 part, ethyl cellulose 1.1 ~ 2.5 parts, hydroxyethylcellulose 0.08 ~ 0.1 part, hydroxypropyl methylcellulose 0.3 ~ 0.35 part, hydroxypropyl cellulose 0.01 ~ 0.02 part, cellulose acetate 0.3 ~ 0.5 part, alkylpolyoxyethylene 7 ~ 9 parts, ethanol 45 ~ 52 parts, toluene 55 ~ 70 parts, 18 ~ 25 parts, acetone,
The described poly degree of polymerization is 2500 ~ 5000, the polyacrylic degree of polymerization is 1800 ~ 2000, the degree of polymerization of polyvinyl formal is 2000 ~ 2500, the degree of polymerization of polymethyl methacrylate is 2000 ~ 2200, the degree of polymerization of gelatin is 6500 ~ 6800, the degree of polymerization of PVP is 3700 ~ 3900, the degree of polymerization of polyvinyl alcohol is 3500 ~ 5000, the degree of polymerization of methylcellulose is 8000 ~ 9500, the degree of polymerization of carboxymethyl cellulose is 7500 ~ 9000, the degree of polymerization of ethyl cellulose is 6800 ~ 7520, the degree of polymerization of hydroxyethylcellulose is 5500 ~ 8000, the degree of polymerization of hydroxypropyl methylcellulose is 5000 ~ 10000, the degree of polymerization of hydroxypropyl cellulose is 10000 ~ 15000, the degree of polymerization of cellulose acetate is 700 ~ 1000.
2. a kind of filmogen according to claim 1, is characterized in that: described ethanol is the hydrous ethanol of volume fraction 80% ~ 87%.
3. a compound method for filmogen according to claim 1, is characterized in that comprising the following steps:
Sp1, preparation the first main resin solution
According to the mass fraction of 0.5 ~ 1.2:0.3 ~ 0.8:0.15 ~ 0.3:0.3 ~ 0.7:0.2 ~ 0.5:55 ~ 70, described polyethylene, polyacrylic acid, polyvinyl formal, polymethyl methacrylate, PVP and toluene are mixed, obtain described first main resin solution;
Sp2, preparation the second main resin solution
Described methylcellulose, carboxymethyl cellulose, ethyl cellulose, hydroxyethylcellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, cellulose acetate, ethanol and the acetone mass fraction according to 0.1 ~ 0.2:0.05 ~ 0.08:1.1 ~ 2.5:0.08 ~ 0.1:0.3 ~ 0.35:0.01 ~ 0.02:0.3 ~ 0.5:45 ~ 52:18 ~ 25 is mixed, obtains described second main resin solution;
Sp3, be mixed with membrane material
Described first main resin solution and the second main resin solution are mixed, described gelatin and polyvinyl alcohol is added successively again by the mass fraction of 0.25 ~ 0.3:0.2 ~ 0.4, mix, static 30min, finally add the alkylpolyoxyethylene of 7 ~ 9 parts of mass fractions, be uniformly mixed, obtain described filmogen.
4. the band film test paper by filmogen film forming according to claim 1, it is characterized in that: comprise test paper body (1), filmogen is had at the outer surface of this test paper body (1), this filmogen forms perforated membrane (2), the aperture of the upper micropore of this perforated membrane (2) is 25 ~ 100nm, the porosity of this perforated membrane (2) is 75% ~ 85%, and the thickness of this perforated membrane (2) is 0.8 ~ 2um.
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| CN201410192794.6A CN103966899B (en) | 2014-05-07 | 2014-05-07 | A kind of filmogen and compound method and the band film test paper by this filmogen film forming |
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| TW201544128A (en) * | 2014-05-30 | 2015-12-01 | Cloudtain Internat Biotech Co Ltd | Film-forming composition and kit containing the same |
| CN113954488B (en) * | 2021-11-18 | 2023-04-25 | 康美包（苏州）有限公司 | Packaging material and preparation method thereof, paper tube and packaging container |
| CN115850766B (en) * | 2022-11-15 | 2023-11-07 | 电子科技大学长三角研究院(湖州) | Preparation method and application of gradient polar gel |
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|---|---|---|---|---|
| AU722471B2 (en) * | 1995-10-17 | 2000-08-03 | Lifescan, Inc. | Blood glucose strip having reduced sensitivity to hematocrit |
| CN1771264A (en) * | 2002-09-17 | 2006-05-10 | 科瓦伦特合伙责任有限公司 | Nanofilm compositions with polymeric components |
| CN101384425A (en) * | 2006-02-20 | 2009-03-11 | 大赛璐化学工业株式会社 | Porous film and multilayer assembly using the same |
| JP6304819B2 (en) * | 2012-06-14 | 2018-04-04 | テルモ株式会社 | Inspection test paper |
| CN102901814B (en) * | 2012-07-12 | 2014-11-26 | 浙江大学 | Atrazine molecular imprinting colloidal gold test strip and application |
-
2014
- 2014-05-07 CN CN201410192794.6A patent/CN103966899B/en not_active Expired - Fee Related
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