CN103964066B - A kind of packing device of lyophilized excipient preparation - Google Patents
A kind of packing device of lyophilized excipient preparation Download PDFInfo
- Publication number
- CN103964066B CN103964066B CN201310045800.0A CN201310045800A CN103964066B CN 103964066 B CN103964066 B CN 103964066B CN 201310045800 A CN201310045800 A CN 201310045800A CN 103964066 B CN103964066 B CN 103964066B
- Authority
- CN
- China
- Prior art keywords
- lyophilized excipient
- excipient preparation
- packing device
- chassis
- separation layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
- B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
Abstract
The present invention relates to a kind of packing device of lyophilized excipient preparation and structure; it is applied to the packaging of lyophilized excipient preparation; especially be to provide it is a kind of there is enough hardness, the lyophilized excipient preparation of sustainable and protection and while meet the good packing device of oxygen barrier damp proof insulation, sealing, and classification of the lyophilized excipient preparation includes being not limited to cosmetics, food, health food and medicine etc..
Description
Technical field
The present invention relates to a kind of packing device of lyophilized excipient preparation and structure, it is applied to the bag of lyophilized excipient preparation
Dress, the classification of the lyophilized excipient preparation includes being not limited to cosmetics, food, health food and medicine etc..
Background technology
Lyophilized excipient preparation is a kind of dosage form prepared using lyophilized figuration technology, by being filled into mould
And the technical process of freeze-drying is molded with.Because such preparation uses freeze drying process, thermally sensitive composition can be protected
It is not destroyed, while another preparation produces a large amount of micropores and duct in itself, allows its disintegration and dissolution velocity quickly, therefore by
To widely using, be applied to the medicines such as oral disnitegration tablet, fast-release tablet, chewable tablets, special cosmetics, food, health food and
In cosmetic field.
The characteristic in a large amount of micropores and duct is produced due to freezing the technical process of excipient preparation, lyophilized excipient preparation is had
There are not high formulation strengths, easy friability and the easily defect such as moisture absorption.Most of medicines, cosmetics, plastics used in food
Packaging can protect the product of easy friability, but sealing difference influence product quality, therefore lyophilized excipient preparation in the market is packed
In there is no using plastic material as inner packing.In order to prevent the processes such as lyophilized excipient preparation and air contact rear oxidation, the moisture absorption
The stability of functional component in preparation is destroyed, the packaged configuration of most of lyophilized excipient preparation is to take double aluminium bags in the market
Dress, the preferably double aluminium packagings of sealing property can make the composition oxygen barrier damp proof insulation in lyophilized excipient preparation, but due to aluminum in itself
Characteristic, it is relatively low that double aluminium pack universal hardness, it is impossible to support and protective effect well are played to the preparation in packaging.
The problem of inventor of the present invention is in order to solve above-mentioned, has made intensive studies and largely puts into practice and test, so that
The present invention is completed, while meeting lyophilized excipient preparation package encapsulation and the requirement greatly of support protectiveness two.
The content of the invention
The purpose of the present invention, is to provide a kind of packing device of lyophilized excipient preparation, is especially to provide a kind of with foot
Enough hardness, the lyophilized excipient preparation of sustainable and protection simultaneously meet the good packing device of oxygen barrier damp proof insulation, sealing simultaneously.
To achieve the above object, packing device of the invention is included with lower component：One chassis, a separation layer and a sealing
Layer.
One chassis, containing single or multiple holders, what each holder contained an opening upwards contains space；
One separation layer, containing one or more holders, its holder shape is consistent with quantity with chassis, and can be complete with chassis
Laminating, what each holder contained opening upwards contains space；
Above-mentioned " multiple " are meant that 2-100, preferably 2-30, most preferably 2-20.
One sealant, can be covered on separation layer and be sealed and do not contacted with chassis, the opening of package isolation layer holder,
And the unsealing edge for being easy to open can be left, and its unsealing edge has no effect on sealing effectiveness.
In the device, chassis material is plastics, polymer resin, plastic cement, metal, lucite or the glass for having certain degree of hardness
Material, plays a supportive role；" certain degree of hardness " refers to hardness number in 2-300N/mm2In the range of, preferably 5-200N/mm2, it is optimal
Select 10-100N/mm2。
Separation layer is one layer of aluminum-plastic composite membrane, including the aluminium foil of different structure, cold stamping shaped solid composite hard sheet and not
Isostructural aluminum-plastic composite membrane etc., coordinates with sealant and plays the effect of oxygen barrier damp proof insulation, form an airtight package environment；
Sealant includes but is not limited to aluminium foil, paper plastic-aluminum, aluminum-plastic composite membrane, heat-sealing aluminium tabletting etc. can be close with separation layer progress
The supplementary material of envelope.
In the structure, each holder of chassis and separation layer have a level or spherical bottom wall, one from the bottom wall edge to
The perisporium of upper extension, and one by the perisporium the outside horizontal-extending roof of apical margin, the bottom wall and perisporium define appearance jointly
Space is filled, and sealant is to be covered on separation layer holder and edge and the pressing of separation layer roof.
For ease of opening sealant, the roof at least side of each holder carries unlatching side or stingy hand that unsealing is pressed,
Sealant can be opened upwards from this unlatching side or stingy hand.
During packaging, each holder contains the lyophilized excipient preparation of an once used amount respectively, the purposes of its lyophilized excipient preparation
Including and be not limited to food, health food, cosmetics and medicine, user when in use, opens sealant and can be taken off lyophilized tax
Type preparation is used.
Figure of description explanation
Fig. 1-1~Fig. 1-7 is that embodiment 1 is illustrated.Fig. 1-1 is the front plan view of embodiment 1；Fig. 1-2 be embodiment 1 just
Face upward view；Fig. 1-3 is the packaging unfolding mode front plan view of embodiment 1；Fig. 1-4 is that embodiment 1 is opened after sealant
Front plan view；Fig. 1-5 is the sectional drawing of embodiment 1；Fig. 1-6 is the packaging unfolding mode sectional drawing of embodiment 1；Fig. 1-7 is
The packaging hierarchicabstract decomposition figure of embodiment 1.
Fig. 2-1~2-4 is that embodiment 2 is illustrated.Fig. 2-1 illustrates for the sealant form of embodiment 2；Fig. 2-2 is embodiment 2
Separation layer form diagram；Fig. 2-3 illustrates for the chassis form of embodiment 2；Fig. 2-4 is the packaging hierarchicabstract decomposition figure of embodiment 2.
Fig. 3-2~3-2 is that embodiment 3 is illustrated.Fig. 3-1 is the sectional drawing of embodiment 3；Fig. 3-2 divides for the packaging of embodiment 3
Layer exploded view.
Embodiment
For the present invention foregoing and technology contents, feature, in following examples and detailed description, can be in clearly
It is existing.
Embodiment 1
The chassis 4 is the hard disk body being made into integration by plastic cement, plastics, metal, lucite or glass material, and is had
Multiple holders 43.What is be brought into close contact with chassis 4 is separation layer 3, and the separation layer 3 is one layer be made up of aluminum-plastic composite membrane, aluminium foil
Film soft or with certain degree of hardness, and stamp out the separation layer holder 32 being brought into close contact with chassis holder 43, and reserve easily
The attacker 5 of sealant is opened in user.The lyophilized excipient preparation 2 for the amount of being intended for single use is packaged in separation layer holder 32, for
User is intended for single use.Sealant 1 is that aluminium foil, paper plastic-aluminum, aluminum-plastic composite membrane etc. can carry out sealed supplementary material with separation layer,
And the semi-transparent secant 31 for being easy to tear is cut out in sealing.
During production, lyophilized excipient preparation 2 is contained in separation layer holder 32, and sealant 1 is covered in separation layer and is held
On seat, pressing machine is recycled to be sealed sealant with separation layer holder edge.Chassis is to fit in advance with separation layer
Cement, or separation layer is fitted what is cemented with chassis again after sealant carries out pressing sealing with separation layer.It is above-mentioned during installing
Process always changes automatic production using automated machine.
In use, opening sealant 1 at stingy hand 5, the lyophilized excipient preparation 2 that single dose is used after monolithic is taken off.
Embodiment 2
The chassis 4 is the hard disk body being made of plastics, with multiple holders 43, the connection edge 42 of each holder and
Pull folding line 41.
What is be brought into close contact with chassis 4 is separation layer 3, the separation layer 3 be one layer be made up of aluminum-plastic composite membrane, aluminium foil it is soft or
Film with certain degree of hardness, and the separation layer holder 32 that punching press is brought into close contact for chassis holder 43.The jelly for the amount of being intended for single use
Dry excipient preparation 2 is packaged in separation layer holder 32, so that user is intended for single use.Sealant 1 is aluminium foil, paper plastic-aluminum, plastic-aluminum
Composite membrane etc. can carry out sealed supplementary material with separation layer, and the semi-transparent secant 31 for being easy to tear is cut out in sealing.
During production, with embodiment 1 similarly, lyophilized excipient preparation 2 is contained in separation layer holder 32 and by sealant 1
Sealed with separation layer holder edge.During installing, said process always changes automatic production using automated machine.
In use, along folding line 41 is pulled the semi-transparent of edge 42, the semi-transparent secant 11 of sealant and separation layer will be connected simultaneously
Secant 31 is fractureed, and holder is used separately, while opening sealant 1 from unencapsulated reserved angular zone 12, takes out lyophilized excipient
Preparation 2 can be used.
Embodiment 3
The chassis 4 is circular, square or irregular shape the bottle being made up of plastics, lucite or glass, with list
Individual chassis holder 43, separation layer holder 32 is brought into close contact with chassis holder 43, and the separation layer 3 is soft or with certain hard by one layer
Aluminum-plastic composite membrane, aluminum foil material or the plastics of degree are stamped to form.
During production, sealant 1 for heat-sealing aluminium tabletting, be embedded in screw socket top cover 7, by lyophilized excipient preparation 2, contain in every
After in absciss layer holder 32, top cover 7 is screwed, sealed using bottle capper.During installing, said process is using automation machine
Tool consistentization is produced automatically.
In use, outwarding winding top cover 7, sealant 1 is opened, lyophilized excipient preparation 2 is taken out and can be used.
As shown in the above description, packaging structure of the present invention can dispense in design the lyophilized excipient preparation of single dose in every
In absciss layer holder 32, fitted seal layer 1 strengthens sealing and product supportive is strengthened on chassis 4, can make the lyophilized of once used amount
Excipient preparation health, safety, and be effectively protected, open sealant 1 and can be used, application method is simple, so of the invention
There is preferable safe ready.
The packaging structure of the present invention is not limited to form cited in embodiment, and embodiment is only the preferable reality of the present invention
Apply example, it is impossible to which protection domain is limited with this.All simple or equivalent changes with described in scope of the presently claimed invention
Change and modify, come under protection scope of the present invention.
Claims (10)
1. a kind of packing device of lyophilized excipient preparation, it is characterised in that including with lower component：
One chassis, with one or more holders, each holder contains space with an opening upwards；And
One separation layer, with the shape one or more holders consistent with chassis with quantity, and fits completely with chassis, Mei Gerong
What seat tool had opening upwards contains space；And
One sealant, can be covered on separation layer and be sealed and do not contacted with chassis, the opening of package isolation layer holder；
The chassis material is plastics, polymer resin, plastic cement, metal or the glass material for having certain degree of hardness, the hardness number on chassis
In 2-300N/mm2In the range of.
2. a kind of packing device of lyophilized excipient preparation as claimed in claim 1, it is characterised in that contain and be in holder
Lyophilized excipient preparation.
3. a kind of packing device of lyophilized excipient preparation as claimed in claim 1, it is characterised in that separation layer is one layer of plastic-aluminum
Composite membrane, the aluminum-plastic composite membrane is selected from the aluminium foil or cold stamping shaped solid composite hard sheet of different structure.
4. a kind of packing device of lyophilized excipient preparation as claimed in claim 1, it is characterised in that sealant is selected from aluminium
Paper tinsel, paper plastic-aluminum, aluminum-plastic composite membrane or heat-sealing aluminium tabletting can carry out sealed supplementary material with separation layer.
5. a kind of packing device of lyophilized excipient preparation as claimed in claim 1, it is characterised in that chassis and separation layer it is every
One holder have a level or spherical bottom wall, a perisporium upwardly extended from the bottom wall edge, and one by the perisporium apical margin
Outside horizontal-extending roof, the bottom wall and perisporium define and contain space jointly, and sealant is to be covered in separation layer holder
Upper and its edge is pressed with separation layer roof.
6. a kind of packing device of lyophilized excipient preparation as claimed in claim 1, it is characterised in that sealant, which leaves, to be easy to out
The unsealing edge opened, and the unsealing edge has no effect on sealing effectiveness.
7. a kind of packing device of lyophilized excipient preparation as claimed in claim 1, it is characterised in that the roof of each holder is set
There are unlatching side or leave stingy hand that side is pressed with unsealing, can open sealant upwards from this unlatching side or stingy hand and use.
8. a kind of packing device of lyophilized excipient preparation as claimed in claim 2, it is characterised in that the use of lyophilized excipient preparation
Way includes and is not limited to edible cosmetic product and medicine.
9. a kind of packing device of lyophilized excipient preparation as claimed in claim 1, it is characterised in that the chassis material is to have
Machine glass.
10. a kind of packing device of lyophilized excipient preparation as claimed in claim 8, it is characterised in that the lyophilized excipient system
The purposes of agent includes health food.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310045800.0A CN103964066B (en) | 2013-02-06 | 2013-02-06 | A kind of packing device of lyophilized excipient preparation |
| PCT/CN2014/071776 WO2014121733A1 (en) | 2013-02-06 | 2014-01-29 | Packaging device for lyophilized excipient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310045800.0A CN103964066B (en) | 2013-02-06 | 2013-02-06 | A kind of packing device of lyophilized excipient preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103964066A CN103964066A (en) | 2014-08-06 |
| CN103964066B true CN103964066B (en) | 2017-09-19 |
Family
ID=51234162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310045800.0A Active CN103964066B (en) | 2013-02-06 | 2013-02-06 | A kind of packing device of lyophilized excipient preparation |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN103964066B (en) |
| WO (1) | WO2014121733A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105883218A (en) * | 2014-10-29 | 2016-08-24 | 李和伟 | Solid-liquid separation prepared-immediate-used packing device and preparation method thereof |
| CN106115075B (en) * | 2016-07-04 | 2018-05-22 | 万华普曼生物工程有限公司 | A kind of Test paper class bubble-cap type packaging structure |
| CN110913829A (en) | 2017-07-12 | 2020-03-24 | 荷兰联合利华有限公司 | Freeze-dried active compositions and systems using same |
| US11730685B2 (en) | 2017-07-12 | 2023-08-22 | Conopco, Inc. | Skin composition booster oil |
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| CN1089829A (en) * | 1992-12-01 | 1994-07-27 | R·P·谢勒有限公司 | Be used to be manufactured on the improved method of the lyophilization medicament in the protruding blister pack of multilamellar |
| US5775505A (en) * | 1996-02-27 | 1998-07-07 | Vasquez; William M. | Blister card package |
| JP2006213369A (en) * | 2005-02-04 | 2006-08-17 | Azegami Seal Insatsu:Kk | Easy-to-open package body and its manufacturing method |
| CN101287593A (en) * | 2005-10-12 | 2008-10-15 | 艾尔坎技术及管理有限公司 | Cold-workable laminate for blister bottom parts |
| WO2009061933A1 (en) * | 2007-11-06 | 2009-05-14 | Monosol, Llc | Water-soluble containers within a secondary blister package |
| CN202201319U (en) * | 2010-11-02 | 2012-04-25 | 浙江金石包装有限公司 | Modified bubble cap package |
| GB2486100A (en) * | 2007-10-12 | 2012-06-06 | Protomed Ltd | Discrete sealed medication vessels held within blister pack |
| CN203199405U (en) * | 2013-02-06 | 2013-09-18 | 李和伟 | Packaging device of lyophilized excipients |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2322055A1 (en) * | 1973-05-02 | 1975-01-30 | Bosch Gmbh Robert | CHILD RESISTANT TABLET PACK |
| US5325968A (en) * | 1993-07-14 | 1994-07-05 | Mcneil-Ppc, Inc. | Package for holding tablets |
| US7226628B2 (en) * | 2003-01-31 | 2007-06-05 | Cai Edward Z | Combined coffee package and dispenser |
| DE102005035705A1 (en) * | 2005-07-27 | 2007-02-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | pharmaceutical blister |
| CN102462665B (en) * | 2010-11-18 | 2016-12-07 | 董玲 | The preparation method of lyophilized excipient |
-
2013
- 2013-02-06 CN CN201310045800.0A patent/CN103964066B/en active Active
-
2014
- 2014-01-29 WO PCT/CN2014/071776 patent/WO2014121733A1/en active Application Filing
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089829A (en) * | 1992-12-01 | 1994-07-27 | R·P·谢勒有限公司 | Be used to be manufactured on the improved method of the lyophilization medicament in the protruding blister pack of multilamellar |
| US5775505A (en) * | 1996-02-27 | 1998-07-07 | Vasquez; William M. | Blister card package |
| JP2006213369A (en) * | 2005-02-04 | 2006-08-17 | Azegami Seal Insatsu:Kk | Easy-to-open package body and its manufacturing method |
| CN101287593A (en) * | 2005-10-12 | 2008-10-15 | 艾尔坎技术及管理有限公司 | Cold-workable laminate for blister bottom parts |
| GB2486100A (en) * | 2007-10-12 | 2012-06-06 | Protomed Ltd | Discrete sealed medication vessels held within blister pack |
| WO2009061933A1 (en) * | 2007-11-06 | 2009-05-14 | Monosol, Llc | Water-soluble containers within a secondary blister package |
| CN202201319U (en) * | 2010-11-02 | 2012-04-25 | 浙江金石包装有限公司 | Modified bubble cap package |
| CN203199405U (en) * | 2013-02-06 | 2013-09-18 | 李和伟 | Packaging device of lyophilized excipients |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103964066A (en) | 2014-08-06 |
| WO2014121733A1 (en) | 2014-08-14 |
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Addressee: Li Hewei Document name: Notification of Passing Examination on Formalities |
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| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Li Hewei Document name: Notification of Publication of the Application for Invention |
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| TR01 | Transfer of patent right |
Effective date of registration: 20190711 Address after: 213125 No. 70 Qingyang Road, Xuejiazhen, Xinbei District, Changzhou City, Jiangsu Province Patentee after: Changzhou Weibo Haitai Biotechnology Co. Ltd. Address before: 101312 No. 6 Anqing Street, Area B, Shunyi Airport Industrial Zone, Beijing Patentee before: Li Hewei |
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| TR01 | Transfer of patent right |