CN103961802A - Self-deforming metal marker - Google Patents
Self-deforming metal marker Download PDFInfo
- Publication number
- CN103961802A CN103961802A CN201310606169.7A CN201310606169A CN103961802A CN 103961802 A CN103961802 A CN 103961802A CN 201310606169 A CN201310606169 A CN 201310606169A CN 103961802 A CN103961802 A CN 103961802A
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- CN
- China
- Prior art keywords
- labelling
- diameter
- deformable metal
- transformation temperature
- ball
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
- A61B2090/3908—Soft tissue, e.g. breast tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3966—Radiopaque markers visible in an X-ray image
Abstract
The invention relates to a self-deforming metal marker used for marking an in-vivo marker for radiological examination or treatment. The self-deforming metal marker is made of memory alloy with the transformation temperature of 20 to 37 DEG C. Under the condition of being lower than the transformation temperature, the self-deforming metal marker is of a straight line segment and is 3mm to 100mm in length and 0.1 to 1.6mm in diameter, and the cross section is in a circular or polygonal shape; under the condition of being higher than the transformation temperature, the self-deforming metal marker is turned into a straight-line segment provided with a marking ball with the diameter of 1mm to 5mm and/or one or two folded or spiral ends. The metal marker can be planted into a body position to be marked through a thin puncture needle, and puncture injury caused by puncturing through a thick puncture needle; the metal marker is in a shape with the large marking ball and two folded or spiral curved ends, is easy to develop through X-ray or CT, and is not prone to migration and shifting in vivo, a target can be positioned accurately, and the metal marker is particularly adaptive to placing into a tumor target volume to be applied with radiotherapy.
Description
Technical field
The present invention relates to a kind ofly from deformable metal labelling, this metal marker volume is little, can be less than through diameter the 18G puncture needle of 1.2mm, or the thinner thin puncture needle target that implants is carried out labelling to target.Can local diameter after this metal marker enters in body become large or folding and be convenient to develop under X-ray examination, two bending is simultaneously not easy migration in vivo.
Background technology
Now long-pending large for the body internal labeling object of radiotherapy, the labelling that needs diameter to be greater than 1.5mm just easily develops, but it is that more than 2mm 16G or thicker thick puncture needle just can implant that so large diameter labelling needs diameter, wound is larger, often be merely able to implantation and show shallow position, cannot react actual position and the motion conditions of deep target, and often easily migration of the labelling of implanting.Want first for overcome existing label traumatic large, show not cleer and peaceful limitation that cannot Real time dynamic display target, we have designed a kind of from deformable metal labelling.This metal marker is simple in structure, and volume is little, and being difficult for migration can carry out labelling to target through the meticulous puncture needle target that implants.
Summary of the invention
According to the present invention, provide a kind of body internal labeling substance markers during for radiographic test or treatment when radiotherapy (especially tumor target area labelling) from deformable metal labelling, by 18～37 DEG C of transformation temperatures, preferably 20～35 DEG C, more preferably the memorial alloy of 20-30 DEG C is made, under the condition lower than transformation temperature (for example, lower than 20 DEG C time), it is for length 3mm is to 100mm, preferably 10～40mm, more preferably 20～30mm, more preferably from about 20mm, diameter 1.6～0.1mm, preferably diameter 0.3～0.8mm, more preferably 0.5～0.6mm, more preferably from about the cross section of 0.6mm is circular or polygonal straight line line segment shape, under the condition higher than described transformation temperature, (for example enter in the more than 37 DEG C body of body temperature) to change into and there is diameter 1mm～5mm in the middle of straight line line segment, the labelling ball of for example 1mm～3mm and/or with the shape of one or two rugosity or helical form end.In the time that the cross section of described straight line line segment is polygon, described diameter is this polygonal equivalent diameter.
Above-mentioned higher than under transformation temperature, have rugosity or helical form end from deformable metal labelling can by by length 3mm to 100mm, preferably 10～40mm, more preferably 20～30mm, more preferably from about 20mm, diameter 0.1～1.6mm, preferably diameter 0.3～0.8mm, more preferably 0.5～0.6mm, more preferably from about the cross section of 0.6mm is that circular or polygonal, transformation temperature is that the memorial alloy of 18～37 DEG C is processed into the shape with rugosity or helical form end when higher than transformation temperature, and then when lower than transformation temperature by its stretching preparation.Above-mentioned can be by being that the memorial alloy of 18～37 DEG C is processed into total length 3mm to 100mm by transformation temperature when higher than transformation temperature from deformable metal labelling higher than what there is labelling ball under transformation temperature, preferably 10～40mm, more preferably 20～30mm, more preferably from about 20mm, there is diameter 1mm centre to for example 1mm～3mm of 5mm() labelling ball, the straight line line segment diameter at the two ends of labelling ball is 0.1～1.6mm, preferably diameter is 0.3～0.8mm, more preferably 0.5～0.6mm, the more preferably from about shape of 0.6mm, and then when lower than transformation temperature, it is stretching, and the labelling ball punching press at Jiang Qi center becomes the straight line line segment shape having with the roughly the same diameter of straight line line segment of labelling ball both sides and obtains.Higher than there is can obtaining by the combination of above-mentioned two kinds of methods from deformable metal labelling of rugosity or helical form end and labelling ball under transformation temperature simultaneously.
Preferably, above-mentioned be marked under the condition higher than described transformation temperature, (for example to enter in the more than 37 DEG C body of body temperature) in the middle of changing into from deformable metal there is for example 1mm～3mm of diameter 1mm～5mm(, 3mm～5mm, 3mm, 5mm etc.) labelling ball and with the shape of two rugosities or helical form end, and the diameter of described labelling ball is greater than the diameter of described straight line line segment.Should can be by being that the memorial alloy of 18～37 DEG C is processed into total length 3mm to 100mm by transformation temperature when higher than transformation temperature from deformable metal labelling, preferably 10～40mm, more preferably 20～30mm, more preferably from about 20mm, there is diameter 1mm centre to for example 1mm～3mm of 5mm() labelling ball, the straight line line segment diameter at the two ends of labelling ball is 0.1～1.6mm, preferably diameter is 0.3～0.8mm, more preferably 0.5～0.6mm, more preferably from about 0.6mm and there is one or two rugosity or the shape of helical form end, and then when lower than transformation temperature, it is stretching, and the labelling ball punching press at Jiang Qi center becomes the straight line line segment shape having with the roughly the same diameter of straight line line segment of labelling ball both sides and obtains.Total length described here is rugosity or the helical form end length after stretching.Labelling ball also can be connect, fold, be wound around and be formed by thick deformable metal silk punching press or grinding by thin deformable metal wire bond.Labelling ball can be positioned at the optional position in the middle of straight line line segment, for example, be in 40～60% positions of the total length of straight line line segment, preferably approximately 50% position of straight line line segment total length.
Described memorial alloy is not particularly limited, as long as there is the transformation temperature of 18～37 DEG C, preferably Ultimum Ti, the memory metal support that is for example the production of Beijing Non-Ferrous Metal Research Yixin New Material Co., Ltd is used, nickel, titanium atom 1:1 ratio, covert temperature is the Nitinol wire material of 20 DEG C.
This processing can be preserved together with its puncture needle from deformable metal labelling in the following for example container below 20 DEG C of transformation temperature, while needs, implant target area (for example, in tumor target area) through puncture (medical science interventional method), its temperature of heating that is subject to body temperature in target area exceedes transformation temperature for example more than 20 DEG C time, automatically becomes with rugosity or helical form end or with rugosity or helical form end and with the curvilinear lengths of labelling ball.Therefore middle labelling bulb diameter easily develops more than 1.5mm, and rugosity or helical form end make to be difficult for migration from deformable metal labelling.
The present invention also provides the above-mentioned purposes that is used as body internal labeling thing in the time that deformable metal is marked at radiographic test or treatment.
The invention has the beneficial effects as follows: can linearity deformable metal the labelling thinner diameter of preserving under low temperature state be implanted and need the position of labelling, the penetration damage of having avoided larger puncture needle to cause with thinner puncture needle; Should present in vivo with the two ends rugosity of larger labelling ball or the shape of helical form bending from deformable metal labelling knot, thisly with the two ends rugosity of labelling ball or the shape of helical form bending, deformable metal labelling was both easily developed under X-ray examination or CT, can there is not in vivo again migration displacement, localizing objects exactly.Be particularly suitable for placing in the tumor target area of plan radiotherapy in the treatment.
Brief description of the drawings
Below in conjunction with drawings and Examples, the present invention and main manufacturing process thereof are further illustrated:
Fig. 1 is marked at external straight line line segment shape schematic perspective view during lower than transformation temperature from deformable metal.
Fig. 2 approaches organism temperature in vivo from deformable metal labelling, and during higher than transformation temperature, the labelling ball 3 that at least one diameter is greater than 1mm is contained in part, the shape of two ends rugosity bending 3.
Fig. 3 shows several modes that form labelling ball under deformable metal is marked at higher than transformation temperature.
In figure: 1, be marked at lower than the straight line line segment under transformation temperature from deformable metal; 2, from the cross section (circle) of deformable metal labelling straight line line segment; 3 is the labelling ball on deformable metal labelling after higher than transformation temperature; 4, after higher than transformation temperature from deformable metal labelling bending two ends; 5, the labelling ball that folding mode forms; 6, the labelling ball that canoe forms.7, the labelling ball that punching press or lapping mode form.
Detailed description of the invention
Illustrate the present invention below in conjunction with accompanying drawing.
As shown in Figure 1, it shows from deformable metal and is marked at external straight line line segment shape schematic perspective view during lower than transformation temperature, it is the memory alloy wire linear cylindrical line segment 1 of diameter 0.6mm, its cross section is circular 2, the 19G that so tiny cylindrical line segment can be 1mm by external diameter or the thinner lancet puncture target target area that implants.
As shown in Figure 2, under the environment higher than deformation temperature, select the satisfactory deformable metal labelling of a deformed diameter ball, one section of memory alloy wire line segment that diameter is 0.6mm of each welding at its two ends, and this line segment is bent to the shape needing, just can form the shape in the time that deformable metal is marked at higher than transformation temperature.
As shown in Figure 3, labelling ball can form by several modes, and 5 represent can form labelling bead by the folding method of deformable metal silk; 6 represent that the method that can be wound around with deformable metal silk forms labelling bead; 7 represent to attenuate with the deformable metal silk two ends punching press of larger diameter, and the method for middle one section of thicker diameter of reservation is made labelling bead.
Application Example
Use nickel, titanium atom 1:1 ratio that Beijing Non-Ferrous Metal Research Yixin New Material Co., Ltd produces, covert temperature is the Nitinol wire material (memorial alloy) of 20 DEG C, under the condition higher than transformation temperature, use above-mentioned nitinol alloy wire materials processing to go out the ball of diameter 3mm, then weld the linearity line segment of the above-mentioned memorial alloy of the diameter 0.6mm that length is about 10mm separately in ball both sides, and the two ends that make line segment are rugosity bending, as shown in Figure 2.And then when lower than transformation temperature, it is stretching, and the labelling ball punching press at Jiang Qi center becomes the straight line line segment shape having with the roughly the same diameter of straight line line segment (i.e. about 0.6mm) of labelling ball both sides.Then sterilization, obtains from deformable metal labelling, preserves in inserting puncture needle under the condition lower than transformation temperature as the linearity line segment of diameter 0.6mm.While carrying out radiotherapy, get involved means by medical science, will send in the tissue of tumor target area through conduit from deformable metal labelling.Show through CT imaging, being marked at from deformable metal the shape presenting in tumor tissues as shown in Figure 2 and (thering is labelling ball of this straight line line segment shape, and two ends are rugosity bending), can develop well, and position is fixed, do not move, thereby can locate well the position of tumor.
Claims (6)
- One kind for radiographic test or when treatment body internal labeling substance markers from deformable metal labelling, by 18～37 DEG C of transformation temperatures, preferably the memorial alloy of 20～35 DEG C is made, under the condition lower than transformation temperature, it is for length 3mm is to 100mm, preferably 10～40mm, more preferably 20～30mm, more preferably from about 20mm, diameter 0.1～1.6mm, preferably 0.3～0.8mm, more preferably 0.5～0.6mm, more preferably from about the cross section of 0.6mm is circular or polygonal straight line line segment shape, change into straight line line segment under the condition higher than described transformation temperature in the middle of, there is the labelling ball of diameter 1mm～5mm and/or the shape with one or two rugosity or helical form end.
- 2. according to claim 1 from deformable metal labelling, wherein, above-mentionedly be marked in the middle of changing under the condition higher than described transformation temperature and there is the labelling ball of diameter 1mm～5mm and the shape with two rugosities or helical form end from deformable metal, and the diameter of described labelling ball is greater than the diameter of described straight line line segment.
- 3. according to claim 1 and 2 from deformable metal labelling, wherein, described memorial alloy is the Ultimum Ti with the transformation temperature of 20～37 DEG C.
- 4. according to claim 1 and 2 from deformable metal labelling, wherein, described memorial alloy is nickel, titanium atom 1:1 ratio, and covert temperature is the Nitinol wire material of 20 DEG C.
- 5. according to claim 2 from deformable metal labelling, wherein, described labelling ball is by the welding of thin memory alloy metal wire, folding, winding or thick deformable metal silk punching press or grind and form.
- According in claim 1-5 any one be marked at radiographic test or when treatment purposes as body internal labeling thing from deformable metal.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310606169.7A CN103961802A (en) | 2013-01-28 | 2013-11-25 | Self-deforming metal marker |
| PCT/CN2013/090074 WO2014114154A1 (en) | 2013-01-28 | 2013-12-20 | Self-deformation metal marker |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310048429 | 2013-01-28 | ||
| CN201310048429.3 | 2013-01-28 | ||
| CN201310606169.7A CN103961802A (en) | 2013-01-28 | 2013-11-25 | Self-deforming metal marker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103961802A true CN103961802A (en) | 2014-08-06 |
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ID=51226902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310606169.7A Pending CN103961802A (en) | 2013-01-28 | 2013-11-25 | Self-deforming metal marker |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN103961802A (en) |
| WO (1) | WO2014114154A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840256A (en) * | 2015-04-30 | 2015-08-19 | 刘弘毅 | Medical marking device for positioning |
| CN105078575A (en) * | 2015-04-30 | 2015-11-25 | 马家骏 | Medical marker device for positioning |
| CN105251126A (en) * | 2015-11-17 | 2016-01-20 | 中国人民解放军第二军医大学 | Tracking marker for stereotactic radiation therapy (SRT) |
| CN106794049A (en) * | 2014-10-08 | 2017-05-31 | Devicor医疗产业收购公司 | Biopsy marker |
| CN110448360A (en) * | 2019-08-19 | 2019-11-15 | 中国石油大学(北京) | A kind of multifunctional heart interval tubulose sting device and preparation method thereof and application |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108969900A (en) * | 2017-12-19 | 2018-12-11 | 袁光金 | Extracranial tumors accurate radiotherapy puts position device |
Citations (3)
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| US6220248B1 (en) * | 1998-10-21 | 2001-04-24 | Ethicon Endo-Surgery, Inc. | Method for implanting a biopsy marker |
| US6766186B1 (en) * | 1999-06-16 | 2004-07-20 | C. R. Bard, Inc. | Post biospy tissue marker and method of use |
| CN101524292A (en) * | 2008-03-03 | 2009-09-09 | 伊西康内外科公司 | Intraluminal tissue markers |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202537630U (en) * | 2012-04-09 | 2012-11-21 | 陕西福泰医疗科技有限公司 | Nickel-titanium memory alloy vertebral expansion support |
-
2013
- 2013-11-25 CN CN201310606169.7A patent/CN103961802A/en active Pending
- 2013-12-20 WO PCT/CN2013/090074 patent/WO2014114154A1/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6220248B1 (en) * | 1998-10-21 | 2001-04-24 | Ethicon Endo-Surgery, Inc. | Method for implanting a biopsy marker |
| US6766186B1 (en) * | 1999-06-16 | 2004-07-20 | C. R. Bard, Inc. | Post biospy tissue marker and method of use |
| CN101524292A (en) * | 2008-03-03 | 2009-09-09 | 伊西康内外科公司 | Intraluminal tissue markers |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106794049A (en) * | 2014-10-08 | 2017-05-31 | Devicor医疗产业收购公司 | Biopsy marker |
| US10492884B2 (en) | 2014-10-08 | 2019-12-03 | Devicor Medical Products, Inc. | Biopsy marker |
| US11123151B2 (en) | 2014-10-08 | 2021-09-21 | Devicor Medical Products, Inc. | Biopsy marker |
| CN104840256A (en) * | 2015-04-30 | 2015-08-19 | 刘弘毅 | Medical marking device for positioning |
| CN105078575A (en) * | 2015-04-30 | 2015-11-25 | 马家骏 | Medical marker device for positioning |
| CN104840256B (en) * | 2015-04-30 | 2017-05-17 | 常州朗合医疗器械有限公司 | Medical marking device for positioning |
| CN105251126A (en) * | 2015-11-17 | 2016-01-20 | 中国人民解放军第二军医大学 | Tracking marker for stereotactic radiation therapy (SRT) |
| CN110448360A (en) * | 2019-08-19 | 2019-11-15 | 中国石油大学(北京) | A kind of multifunctional heart interval tubulose sting device and preparation method thereof and application |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014114154A1 (en) | 2014-07-31 |
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| PB01 | Publication | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20140806 |