CN103961395A - Composition of plant extract and method for regulating and controlling blood sugar by using same - Google Patents
Composition of plant extract and method for regulating and controlling blood sugar by using same Download PDFInfo
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- CN103961395A CN103961395A CN201410215664.XA CN201410215664A CN103961395A CN 103961395 A CN103961395 A CN 103961395A CN 201410215664 A CN201410215664 A CN 201410215664A CN 103961395 A CN103961395 A CN 103961395A
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Abstract
The invention provides a composition of plant extract and a method for regulating and controlling blood sugar by using the same. The composition of a plant extract comprises a glycosidase inhibitor used for blocking digestion and absorption of sugar by organism, and a sodium glucose transporter inhibitor used for inhibiting sodium glucose transporter so as to inhibit the reabsorption of the glucose by kidney. The glycosidase inhibitor comprises L-arabinose, 1-deoxynojirimycin, phaseolin or chlorogenic acid; the sodium glucose transporter inhibitor is extracted from phlorizin; the phlorizin is extracted from lithocarpus polysachyus rehd, branches or leaves of a fruit tree. On the one hand, the composition provided by the invention can be used for blocking excessive absorption of the sugar, on the other hand, the composition can be used for inhibiting the sodium glucose transporter in the kidney to control the reabsorption of the glucose so as to ultimately lower blood sugar and balance the blood glucose level within the scope of health.
Description
Technical field
The present invention relates to medical health field, particularly a kind of composition of plant extracts and the method for regulating and controlling blood sugar thereof.
Background technology
For a long time, particularly nearest decades, due to change and the industrialized retrofit of food product of diet and living habit, people cause the metabolism syndrome including obesity, diabetes, cardiovascular and cerebrovascular disease, cancer to the excessive absorption of sugar (sucrose and starch based polysaccharide); Central nervous system's syndrome chronic diseases including senile dementia, Parkinson's disease is suffered from ratio and is rapidly risen.This class is of all ages, regardless of sex, regardless of region, the quality of life that non-racial, long-term, painful chronic disease not even point society and politics, economic status has had a strong impact on people, brought the financial burden that is difficult to bear to individual, government.Although health care industry is constantly upgraded, medical treatment level improves constantly, the medical insurance of individual, society and government drops into and improves constantly, it is reported Chinese adult's diabetes ratio or from the less than 1% in the 1980's develop into 2013 11.6%, exceeding the U.S. becomes the highest country of glycosuria sickness rate of the world.According to another report, only country of the U.S., in 2,012 one year, treatment diabetes have just spent 2,450 hundred million dollars.On November 13rd, 2013, the previous day of world's diabetes day, global diabetics number will be ascended to heaven to 300,000,000 8 thousand 2 hundred ten thousand from 300,000,000 4 thousand 7 hundred ten thousand of the end of the year 2012, less than within 1 year, just having increased by 3,000 5 million peoples! In recent years, particularly from the end of the eighties in last century, by a large amount of theoretical research of scientific research professional and animal and human clinical trial's the result of multiple countries, multiple mechanisms, the pathogenesis of the people infringement to health and various diseases to excessive sugar in body and the advanced glycosylation end products that produced by their has had more fully to be understood, control body blood glucose value, make it remain on the topmost basic means that has just become to prevent and treat these chronic diseases in normal range.
Effectively control and reduce superelevation blood sugar level, medical brainstrust has been developed various medicines.Wherein have two large classes with the present invention is functionally similar: the absorption of direct control unit body sugar (be mainly from the sucrose of sugar and fruit, vegetable and carry out self-carbon water compound and the starch based polysaccharide of potato class vegetable) be that passing through of working in digestive system suppresses the glycoside hydrolases such as saccharase and alpha-glucosidase and make more than 95% sucrose of the sugar that people obtain from diet structure and starch based polysaccharide can not obtain hydrolysis to be transformed into monosaccharide (glucose and fructose) the class inhibitor that human body can absorb; And passing through of working in kidney suppresses sodium glucose transporter (SGLTs or claim SLC5 family) and glucose in blood can not successfully be absorbed in renal proximal tubules and blood sugar lowering medicine that the class inhibitor of discharging with urine is main flow again.
The representative of first kind medicine is acarbose (Acarbose); Equations of The Second Kind medicine be represented as Kan Gelie clean (Canagliflozin)
These controls or to fall the hypoglycemic medicine overwhelming majority be synthetic, targeting is strong but target is single, and toxic and side effects is large, only not ideal enough from provable its effect of unrestrained development trend of diabetes.First, these medicines lack effective means because metabolism burden and other side effect are subject to dose limitation to the control of sugar intake; The inhibitor of the glycoside hydrolase using at present is in addition not good to the inhibition of sugar (sucrose).Secondly, being used at present the medicine overwhelming majority of blood sugar lowering is synthetic, and in use, toxic and side effects is obvious, and long-term taking very easily damages patient's the organ such as liver, kidney.Again, because patient's blood glucose is higher, suppress sodium glucose transporter by medicine and make glucose in blood all even do not brought out the new defect such as cancer because draining the too high infection inflammation that causes of sugar through urinary system by resorbent several drugs.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of composition of plant extracts and the method for regulating and controlling blood sugar thereof.For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
A kind of composition of plant extracts, comprising:
Glycosidase inhibitor, for blocking body digesting and assimilating saccharide; And
Sodium glucose transporter inhibitor, for suppressing sodium glucose transporter, to suppress kidney absorbing again glucose.
Further, in described composition of plant extracts, described glycosidase inhibitor is selected from one or more in L-arabinose, 1-DNJ, phaseolin or chlorogenic acid.
Further, in described composition of plant extracts, described sodium glucose transporter inhibitor is from phlorhizin, and described phlorhizin is from Pasania cuspidata, fruit tree branch and leaf or fruit tree root bark.
Further, in described composition of plant extracts, described L-arabinose is from hemicellulose or pectic substance.
Further, in described composition of plant extracts, described hemicellulose is from the plant cell wall of skin of Semen Maydis, corncob cellulose and Radix Betae, root of Fructus Mali pumilae or Pericarpium Mali pumilae.
Further, in described composition of plant extracts, described 1-DNJ is from moraceae plants, Commelianaceae plant or liliaceous plant.
Further, in described composition of plant extracts, described phaseolin is from Semen Phaseoli Vulgaris.
Further, in described composition of plant extracts, described chlorogenic acid is from Flos Lonicerae, the Cortex Eucommiae or green coffee.
A kind of food or health product, the effective ingredient of described food or health product is a kind of composition of plant extracts, described composition of plant extracts comprises:
Glycosidase inhibitor, for blocking body digesting and assimilating saccharide; And
Sodium glucose transporter inhibitor, for suppressing sodium glucose transporter, to suppress kidney absorbing again glucose.
A method for regulating and controlling blood sugar, comprises step: throw in a kind of composition of plant extracts or food or health product containing this composition of plant extracts by digestive tract to human body, described composition of plant extracts comprises:
Glycosidase inhibitor, for blocking body digesting and assimilating saccharide; And
Sodium glucose transporter inhibitor, for suppressing sodium glucose transporter, to suppress kidney absorbing again glucose.
Processing extract such as L-arabinose, 1-DNJ, phaseolin and the chlorogenic acid of the present invention by utilizing natural plants etc. multiple glycosidase inhibitor mutually supplements in digestive system, common glucose and fructose after suppressing the glycoside hydrolases such as saccharase and alpha-glucosidase and blocking sucrose and starch based polysaccharide and be hydrolyzed enters blood circulation, has also just reduced it and has caused various diseases, brings the risk of long-term grievous injury to body.In the excessive absorption of blocking-up sugar, the present invention, by utilizing natural plants as processing extract such as the phlorhizin of the branch and leaf of the fruit tree such as Fructus Mali pumilae and Fructus Pruni pseudocerasi, root bark and Pasania cuspidata suppresses absorption again that sodium glucose transporter controls glucose to reach final reduction blood glucose in kidney, is equilibrated at blood glucose value in healthy horizontal extent.
Detailed description of the invention
By describing technology contents of the present invention, structural feature in detail, being realized object and effect, be explained in detail below in conjunction with embodiment.
The raw material that composition of plant extracts of the present invention adopts all, from the processing extract of natural plants, is considered incompatibility, final products no side effects in addition in the time of formula.Described compositions comprises glycosidase inhibitor, specifically comprises L-arabinose, 1-DNJ, phaseolin and chlorogenic acid.Wherein L-arabinose, from the hemicellulose and the pectic substance that are extracted from the plant cell walls such as skin of Semen Maydis, corncob cellulose, frumentum and Radix Betae, Fructus Mali pumilae; 1-DNJ, from Moraceae, Commelianaceae and liliaceous plant; Phaseolin, from Semen Phaseoli Vulgaris; Chlorogenic acid, from Flos Lonicerae, the Cortex Eucommiae and green coffee.Glycosidase inhibitor can effectively be blocked body digesting and assimilating the saccharide including starch.For completing comprehensive blood sugar lowering effectively to control blood sugar level, composition of plant extracts of the present invention also comprises sodium glucose transporter inhibitor phlorhizin, from natural plants such as Pasania cuspidata, fruit tree branch and leaf or fruit tree root bark, its function is inhibition sodium glucose transporter, it can not be absorbed the glucose in blood at kidney again, and discharges through urinary system.So, the glycosidase inhibitor in described compositions has been blocked the absorption of sugar, is further made sugar level be declined by glucose in sodium glucose transporter inhibitor occlude blood after the resorption of kidney.In addition, in compositions, also include antiinflammatory antiinflammatory effective ingredient, can effectively prevent urinary system infection inflammation and other side effect.
Processing extract such as L-arabinose, 1-DNJ, phaseolin and the chlorogenic acid of the present invention by utilizing natural plants etc. multiple glycosidase inhibitor mutually supplements in digestive system, common glucose and fructose after suppressing the glycoside hydrolases such as saccharase and alpha-glucosidase and blocking sucrose and starch based polysaccharide and be hydrolyzed enters blood circulation, has also just reduced it and has caused various diseases, brings the risk of long-term grievous injury to body.
Described plant extract comprises that Herb to plant or live part make as the processing of the physics such as dry, cutting, pulverizing, the process of preparing Chinese medicine, calcining, fermentation, extraction, extraction, chemistry, biological method through various mode.These plants comprise: can from the hemicellulose of their cell wall and pectic substance, extract the rosaceous plants such as the vegetable such as grass, Radix Betae that comprises Semen Maydis and various frumentums, Fructus Mali pumilae, Fructus Pruni pseudocerasi of L-arabinose; Can extract the section plants such as 1-DNJ Moraceae, Commelianaceae and Bulbus Lilii; Can extract Semen Phaseoli Vulgaris and other plant of phaseolin; Contain Flos Lonicerae, the Cortex Eucommiae and green coffee of chlorogenic acid etc.
In the excessive absorption of blocking-up sugar, the present invention, by utilizing natural plants as processing extract such as the phlorhizin of the branch and leaf of the fruit tree such as Fructus Mali pumilae and Fructus Pruni pseudocerasi, root bark and Pasania cuspidata suppresses absorption again that sodium glucose transporter controls glucose to reach final reduction blood glucose in kidney, is equilibrated at blood glucose value in healthy horizontal extent.
The mode that feeds of formulation product of the present invention comprises: decoction pieces, tablet, capsule, soft capsule, gelinite, powder, granule, disintegrator, tea bag, water preparation and other dosage form.
The first embodiment: a kind of composition of plant extracts, comprising:
L-arabinose, extracts from grass if Semen Maydis and various frumentum, vegetable are if Radix Betae, fruit are as Fructus Mali pumilae and Fructus Pruni pseudocerasi;
1-DNJ, extracts from Morus alba and Herba Commelinae;
Phaseolin, extracts from Semen Phaseoli Vulgaris;
Chlorogenic acid, extracts from Flos Lonicerae and the Cortex Eucommiae;
Sodium glucose transporter inhibitor, extracts from Pericarpium Mali pumilae, Pasania cuspidata.
Its major function is the object that the absorption again of blocking-up sucrose and the saccharoidal absorption of starch and glucose reaches comprehensive blood sugar lowering.
The second embodiment: a kind of composition of plant extracts, comprising:
L-arabinose, extracts from grass if Semen Maydis and various frumentum, vegetable are if Radix Betae, fruit are as Fructus Mali pumilae and Fructus Pruni pseudocerasi;
1-DNJ, extracts from Morus alba and Herba Commelinae;
Phaseolin, extracts from Semen Phaseoli Vulgaris;
Chlorogenic acid, extracts from Flos Lonicerae and the Cortex Eucommiae.
Its major function is blocking-up sucrose and the saccharoidal absorption of starch.
The 3rd embodiment: a kind of composition of plant extracts, comprising:
L-arabinose, extracts from grass if Semen Maydis and various frumentum, vegetable are if Radix Betae, fruit are as Fructus Mali pumilae and Fructus Pruni pseudocerasi;
Sodium glucose transporter inhibitor, extracts from Pericarpium Mali pumilae, Fructus Mali pumilae tree root and skin, Fructus Pruni pseudocerasi tree root and skin, Pasania cuspidata;
Major function is blocking-up sucrose and the saccharoidal absorption of starch, and in kidney, suppresses absorption again that sodium glucose transporter controls glucose to reach final reduction blood glucose.
The 4th embodiment: a kind of composition of plant extracts, comprising:
L-arabinose, extracts from grass if Semen Maydis and various frumentum, vegetable are if Radix Betae, fruit are as Fructus Mali pumilae and Fructus Pruni pseudocerasi;
1-DNJ, extracts from Morus alba and Herba Commelinae;
Sodium glucose transporter inhibitor, extracts from Pericarpium Mali pumilae, Pasania cuspidata, Coriolous Dersicolor (Fr.) Quel.
Major function is blocking-up sucrose and the saccharoidal absorption of starch, and in kidney, suppresses sodium glucose transporter and control absorbing again of glucose, more effectively controls blood sugar level comprehensively.
Disclose composition of plant extracts described in the respective embodiments described above in the application of preparing aspect food or the health product of regulating and controlling blood sugar at another embodiment of the invention.
The foregoing is only embodiments of the invention; not thereby limit the scope of the claims of the present invention; every equivalent structure or conversion of equivalent flow process that utilizes description of the present invention to do; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (10)
1. a composition of plant extracts, is characterized in that, comprising:
Glycosidase inhibitor, for blocking body digesting and assimilating saccharide; And
Sodium glucose transporter inhibitor, for suppressing sodium glucose transporter, to suppress kidney absorbing again glucose.
2. composition of plant extracts as claimed in claim 1, is characterized in that, described glycosidase inhibitor is selected from one or more in L-arabinose, 1-DNJ, phaseolin or chlorogenic acid.
3. composition of plant extracts as claimed in claim 1 or 2, is characterized in that, described sodium glucose transporter inhibitor is from phlorhizin, and described phlorhizin is from Pasania cuspidata, fruit tree branch and leaf or fruit tree root bark.
4. composition of plant extracts as claimed in claim 1 or 2, is characterized in that, described L-arabinose is from hemicellulose or pectic substance.
5. composition of plant extracts as claimed in claim 4, is characterized in that, described hemicellulose is from the plant cell wall of skin of Semen Maydis, corncob cellulose and Radix Betae, root of Fructus Mali pumilae or Pericarpium Mali pumilae.
6. composition of plant extracts as claimed in claim 1 or 2, is characterized in that, described 1-DNJ is from moraceae plants, Commelianaceae plant or liliaceous plant.
7. composition of plant extracts as claimed in claim 1 or 2, is characterized in that, described phaseolin is from Semen Phaseoli Vulgaris.
8. composition of plant extracts as claimed in claim 1 or 2, is characterized in that, described chlorogenic acid is from Flos Lonicerae, the Cortex Eucommiae or green coffee.
9. food or health product, is characterized in that, described food or health product comprise the composition of plant extracts as described in claim 1 to 8 any one.
10. a method for regulating and controlling blood sugar, is characterized in that, comprises step: throw in composition of plant extracts, food or health product as claimed in any one of claims 1-9 wherein by digestive tract to human body.
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| WO2015159195A1 (en) * | 2014-04-13 | 2015-10-22 | Marmar Investment Sp. Z O.O. | Dietary compositions for reducing blood glucose levels and for weight management |
| CN105012393A (en) * | 2015-06-08 | 2015-11-04 | 广西壮族自治区蚕业技术推广总站 | Preparation method for binary sucrase inhibitor |
| CN105055399A (en) * | 2015-08-19 | 2015-11-18 | 西安膳方医药科技有限公司 | Natural product composition for preventing and treating diabetes and application thereof |
| CN105126066A (en) * | 2015-08-24 | 2015-12-09 | 西安膳方医药科技有限公司 | Composition for enhancing diabetes prevention and treatment functions of secoisolariciresinol diglucoside and application of composition |
| CN107114787A (en) * | 2017-05-09 | 2017-09-01 | 宝健（北京）生物技术有限公司 | A kind of composition of prevention heat absorption |
| CN108420065A (en) * | 2018-03-30 | 2018-08-21 | 山东诺贝肽生物科技有限公司 | A kind of antihypelipidemic product rich in bitter gourd polypeptide |
| WO2019201315A1 (en) * | 2018-04-20 | 2019-10-24 | 中国科学院上海药物研究所 | Composition containing phlorizin and 1-deoxynojirimycin and use thereof |
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| WO2022121986A1 (en) * | 2020-12-10 | 2022-06-16 | 湖南翱康生物科技有限公司 | Novel medicament for preventing and treating neurodegenerative diseases |
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| US11071767B2 (en) | 2014-04-13 | 2021-07-27 | Marmar Investment Sp. Z O.O. | Dietary compositions for reducing blood glucose levels and for weight management |
| CN106456692A (en) * | 2014-04-13 | 2017-02-22 | 马尔玛投资有限公司 | Dietary compositions for reducing blood glucose levels and for weight management |
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| CN105012393A (en) * | 2015-06-08 | 2015-11-04 | 广西壮族自治区蚕业技术推广总站 | Preparation method for binary sucrase inhibitor |
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| CN105055399A (en) * | 2015-08-19 | 2015-11-18 | 西安膳方医药科技有限公司 | Natural product composition for preventing and treating diabetes and application thereof |
| CN105126066A (en) * | 2015-08-24 | 2015-12-09 | 西安膳方医药科技有限公司 | Composition for enhancing diabetes prevention and treatment functions of secoisolariciresinol diglucoside and application of composition |
| CN107114787B (en) * | 2017-05-09 | 2020-11-13 | 宝健（北京）生物技术有限公司 | Composition for preventing heat absorption |
| CN107114787A (en) * | 2017-05-09 | 2017-09-01 | 宝健（北京）生物技术有限公司 | A kind of composition of prevention heat absorption |
| CN108420065A (en) * | 2018-03-30 | 2018-08-21 | 山东诺贝肽生物科技有限公司 | A kind of antihypelipidemic product rich in bitter gourd polypeptide |
| WO2019201315A1 (en) * | 2018-04-20 | 2019-10-24 | 中国科学院上海药物研究所 | Composition containing phlorizin and 1-deoxynojirimycin and use thereof |
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| CN115038340A (en) * | 2019-12-16 | 2022-09-09 | 昊福食品私人有限公司 | Preparation, composition or food additive for changing blood sugar reaction, and its preparation method and application |
| CN111592461A (en) * | 2020-04-20 | 2020-08-28 | 广州能靓生物技术有限公司 | Extraction method of chlorogenic acid |
| CN111592461B (en) * | 2020-04-20 | 2021-08-06 | 广州能靓生物技术有限公司 | Composition with blood sugar reducing effect |
| WO2022121986A1 (en) * | 2020-12-10 | 2022-06-16 | 湖南翱康生物科技有限公司 | Novel medicament for preventing and treating neurodegenerative diseases |
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