CN1039410C - Process for preparing alkylaminoalkyl methylacrylate - Google Patents
Process for preparing alkylaminoalkyl methylacrylate Download PDFInfo
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- CN1039410C CN1039410C CN93111314A CN93111314A CN1039410C CN 1039410 C CN1039410 C CN 1039410C CN 93111314 A CN93111314 A CN 93111314A CN 93111314 A CN93111314 A CN 93111314A CN 1039410 C CN1039410 C CN 1039410C
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- stopper
- reaction
- catalyzer
- zinc
- ester
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Abstract
The present invention relates to a preparation method for methylpropenoic acid alkyl amino alkane ester. Raw materials are prepared by the ester exchange reaction of methyl methacrylate (or methyl acrylate) and alkyl aminoalcohol. Zinc salt catalysts which have the advantages of high activity, no pollution, low cost and simple post-treatment and can be recovered are used and comprises zinc chloride, zinc carbonate and zinc acetate dihydrate. Inhibitors containing nitroxyl radicals are used, and compared with the prior art, the effect of inhibition is improved.
Description
The invention relates to a kind of new manufacture method of the alkylamino ester of methacrylic acid (or vinylformic acid).
Methacrylic acid (or vinylformic acid) alkylamino alkane ester is the important fine chemical product of a class, can be applicable to fields such as polymeric flocculant, sheet processing auxiliary agent, fibre finish, plastic, rubber properties-correcting agent, oil dope, coating and tackiness agent.
People are known, and methacrylic acid (or vinylformic acid) alkylamino alkane ester carries out transesterification reaction by methyl methacrylate (or methyl acrylate) and alkyl amino alcohols and makes.This reacts in the past that the catalyzer of usefulness is the alcoholate (Britl, 174,148) of alkaline-earth metal, and the organic compound of organic compound of titanium (ToKKYoKo ho 79,163,517 for Jpn, KoKai) or tin (JpnkoKai 78,34, and 714; Ger2,725,255) etc.But when utilizing above-mentioned catalyzer, have many shortcomings, for example, the alcoholate of alkaline-earth metal is very sensitive to water, and reactive behavior is subjected to the influence of water bigger, thereby strict to the requirement of moisture in the reaction system, need dewater and react.When making catalyzer with the organic compound of titanium or tin, except that catalyst themselves costs an arm and a leg, prepares the complexity, catalyzer also is difficult to reclaim, and the processing of its spent catalyst is also difficult, easily causes three-waste pollution.
For inhibited reaction raw material or product polymerization, need to add stopper in the reaction process, used stopper is thiodiphenylamine, Resorcinol, phenyl-a-naphthylamine, cupferron etc. usually.But when using above-mentioned stopper, all there is polymerism in various degree.
To the objective of the invention is that a kind of activity is higher, cheap and easy to get, aftertreatment is simple and the catalyzer of recyclable utilization and the significant stopper of polymerization inhibition effect in order providing, to solve the shortcoming of above-mentioned catalyzer and stopper.
The general introduction of invention; The present invention is when carrying out transesterification reaction manufacturing methacrylic acid (or vinylformic acid) alkylamino alkane ester with methyl methacrylate (or methyl acrylate) and alkyl amino alcohols, adopting the salt compounds of zinc is catalyzer, as adopt the salt compounds of metals such as zinc chloride, zinc carbonate, zinc acetate to make catalyzer, the catalytic activity of this catalyzer is subjected to the influence of water less, do not need raw material is dewatered, and it is cheap and easy to get, aftertreatment is simple, reaction finishes the back and catalyzer can be separated with reaction product by filtering, but the catalyzer direct reuse after the separation.
The present invention adopts nitroxyl free radical class stoppers such as piperidinol nitroxyl radical and piperidine NO free radical phosphorous acid ester, and is more remarkable than stopper polymerization inhibition effect in the past.The alkyl amino alcohols of raw material can be represented by the formula:
R
1R
2N(CH
2)
nOH
R in the formula
1For hydrogen atom or carbonatoms are that the alkane of 1-6 exists R
2Be that carbonatoms is the alkyl of 1-6, n is the integer of 2-6.
Describe manufacturing processed of the present invention below in detail.
Manufacture method of the present invention is under the situation of heated and stirred, methacrylic methyl esters (or methyl acrylate), alkyl amino alcohols and catalyzer, stopper etc. is mixed react.After reaction finishes,, then filtrate is carried out underpressure distillation, thereby make the alkylamino alkane ester of purpose product methacrylic acid (or vinylformic acid) by filtering with the catalyst recovery utilization.
For example, be that raw material reacts when making dimethylaminoethyl methacrylate with methyl methacrylate and dimethylaminoethanol, can be represented by the formula than reaction:
Usually, the usage quantity of alkyl amino alcohols is 1 mole, and the usage quantity of corresponding methyl methacrylate (or methyl acrylate) is the 1.2-10 mole.
The usage quantity of this catalyzer is the 0.5-15% of methyl methacrylate (or methyl acrylate) and alkyl amino alcohols gross weight.Transesterification reaction can be carried out under normal pressure, also can under reduced pressure carry out, and reaction pressure is 0.013MPa-0.1MPa, answers temperature in pressure is determined scope, decides according to the boiling point of reaction system, generally in 5.0-150 ℃ of scope.
In order to obtain the purpose product of high receipts degree, by-product carbinol must be removed from system, specific practice is to carry out with reaction, the azeotrope of methyl alcohol and methacrylic methyl esters (or methyl acrylate) is steamed, thereby it is complete that reaction is carried out.Used reflux ratio is usually 1: 1-10: between 1.
Reaction times is generally 3-8 hour by the decision of factors such as proportioning raw materials, pressure, temperature and catalyzer add-on.In the reaction process, in order to prevent polymerization, usually add stopper, used stopper can be Resorcinol, hydroquinone monomethyl ether, thiodiphenylamine, phenyl-a-naphthylamine, phenyl-a-naphthylamine and piperidine NO free radical phosphorous acid ester and piperidinol nitroxyl radical class stopper, preferably use nitroxyl free radical class stopper, the add-on of stopper is the 0.01-5% of reaction solution gross weight.
Reaction is at first filtered after finishing, and catalyst separating is reclaimed, and the methyl methacrylate (or methyl acrylate) that filtrate is under reduced pressure reacted in the future distills from reaction solution and removes then.Redistillation promptly gets the alkylamino alkane ester of purpose product methacrylic acid (or vinylformic acid).
The effect of invention:
With the product dimethylaminoethyl methacrylate that the present invention obtains, product purity 99.3%, in the dimethylaminoethanol that adds, yield is 92%, and does not pollute.
Catalyzer of the present invention can reclaim use repeatedly repeatedly, for example reclaims 5 times and still can reach following effect.
Table 1
| The reuse number of times | ??1 | ??2 | ??3 | ??4 | ??5 |
| Yield (%) | 92.8 | ?91.6 | ?92.3 | ?92.0 | ?92.1 |
| Purity (%) | 99.4 | ?99.6 | ?99.4 | ?98.9 | ?99.2 |
Under catalyzer and the also identical situation of processing condition, operation steps, change the kind of stopper, investigate down with the polymerization inhibition effect of stopper.The results are shown in table 2.
Table 2
| The stopper title | Superpolymer growing amount (g) |
| Resorcinol | ????9.1 |
| Phenyl-a-naphthylamine | ????13.1 |
| The hydroquinone monomethyl ether | ????7.1 |
| Cupferron | ????13.1 |
| Thiodiphenylamine | ????6.6 |
| Piperidinol nitroxyl radical (the present invention) | ????4.1 |
| Piperidine NO free radical phosphorous acid ester (the present invention) | ????3.7 |
The superpolymer growing amount that stopper of the present invention is described is little, and polymerization inhibition effect is good.
Compare with catalyzer in the past, to have specific activity higher suitable with prior art for used catalyzer in the method for the present invention, but cheap and easy to get, aftertreatment simple, three-waste free pollution and the characteristics that can recycle.Compare with stopper in the past, used stopper has the amount of polymers that is generated in significant polymerization inhibition effect, the reaction and significantly reduces in the inventive method.
Embodiment 1
In the glass flask that agitator, thermometer and separation column are housed, add dimethylaminoethanol 35.6g, methyl methacrylate 80g, catalyzer zinc chloride 2.5g, piperidinol nitroxyl radical stopper 0.2g, heating while stirring under the normal pressure, the fractionator overhead temperature maintenance is about 652, and reflux ratio is 6.Carry out with reaction, the azeotrope of distillation for removing methanol-methyl methacrylate reacts after 6 hours and finishes.With reacting liquid filtering, filtrate is distilled under 20mmHg pressure and is removed unreacted methyl methacrylate, distills to obtain the amino own ester 5.78g of product dimethylaminoethyl acrylate methyl base then under 5mmHg pressure.Use acetic acid and zinc carbonate respectively.
Embodiment 2-3
Equipment therefor is with embodiment 1, and operation steps is also identical, only changes catalyst type and uses zinc acetate and zinc carbonate respectively, obtains the purpose product.
Claims (2)
1. the manufacture method of the amino alkane ester of methacrylic acid or acrylic acid alkyl, be in the presence of zinc salt catalyzer and stopper, to carry out transesterification reaction with methyl methacrylate or methyl acrylate and alkyl amino alcohols to form, it is characterized in that: adopt nitroxyl free radical class material to make stopper, its add-on is 0.01%～5% (wt) of reaction-ure mixture; Reaction finishes the back by filtering reaction product and catalyst separating, and the catalyzer after the separation is recyclable multiplexing.
2. method according to claim 1 is characterized in that described stopper is piperidinol nitroxyl radical or piperidines ammonia oxyradical phosphorous acid ester.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111314A CN1039410C (en) | 1993-06-18 | 1993-06-18 | Process for preparing alkylaminoalkyl methylacrylate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111314A CN1039410C (en) | 1993-06-18 | 1993-06-18 | Process for preparing alkylaminoalkyl methylacrylate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1096510A CN1096510A (en) | 1994-12-21 |
| CN1039410C true CN1039410C (en) | 1998-08-05 |
Family
ID=4989111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93111314A Expired - Lifetime CN1039410C (en) | 1993-06-18 | 1993-06-18 | Process for preparing alkylaminoalkyl methylacrylate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1039410C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102372644A (en) * | 2010-08-23 | 2012-03-14 | 歙县元一科技有限公司 | Production process of dimethylaminoethyl methacrylate |
| ES2640447T3 (en) * | 2010-09-23 | 2017-11-03 | Basf Se | Process for the production of esters of (meth) acrylic acid of N, N-substituted amino alcohols |
| JP6809043B2 (en) * | 2015-09-03 | 2021-01-06 | 東亞合成株式会社 | Method for producing monofunctional (meth) acrylate |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3642877A (en) * | 1968-12-27 | 1972-02-15 | Du Pont | Process for the preparation of dimethylaminoethyl methacrylate |
| US3872161A (en) * | 1972-03-06 | 1975-03-18 | Nippon Catalytic Chem Ind | Process for the manufacture of alkylaminoalkyl acrylates |
| US4059617A (en) * | 1976-04-29 | 1977-11-22 | American Cyanamid Company | Synthesis of dimethylaminoethyl methylmethacrylate |
-
1993
- 1993-06-18 CN CN93111314A patent/CN1039410C/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3642877A (en) * | 1968-12-27 | 1972-02-15 | Du Pont | Process for the preparation of dimethylaminoethyl methacrylate |
| US3872161A (en) * | 1972-03-06 | 1975-03-18 | Nippon Catalytic Chem Ind | Process for the manufacture of alkylaminoalkyl acrylates |
| US4059617A (en) * | 1976-04-29 | 1977-11-22 | American Cyanamid Company | Synthesis of dimethylaminoethyl methylmethacrylate |
Non-Patent Citations (1)
| Title |
|---|
| 精细化学品辞典 1989.6.1 (日)精细化学品辞典编辑委员会编；禹茂章等译校 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1096510A (en) | 1994-12-21 |
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Owner name: CHINA PETROCHEMICAL CORPORATION Free format text: FORMER OWNER: SINOPEC QILU PETRO-CHEMICAL CORP.; INST. OF QILU PETRO-CHEMICAL INDUSTRY CO. Effective date: 20071228 |
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Effective date of registration: 20071228 Address after: Linzi Zibo District, Shandong province Sinopec Qilu Branch of science and technology Patentee after: China Petrochemical Group Corp. Address before: Zibo City, Shandong Province, 124 mailbox Zip code: 255436 Patentee before: Qilu Petrochemical Company of China Petrochemical Corp. Patentee before: Qilu Petrochemical Company Research Institute |
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Expiration termination date: 20130618 Granted publication date: 19980805 |