CN103933040A - 一种加强型神经阻滞药物组合物 - Google Patents

一种加强型神经阻滞药物组合物 Download PDF

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Publication number
CN103933040A
CN103933040A CN201410113735.5A CN201410113735A CN103933040A CN 103933040 A CN103933040 A CN 103933040A CN 201410113735 A CN201410113735 A CN 201410113735A CN 103933040 A CN103933040 A CN 103933040A
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pharmaceutical composition
nerve
parts
blocking
nerve block
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王寿世
宋婷婷
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Abstract

本发明涉及一种加强型神经阻滞药物组合物，由以下体积分数的组分组成：0.75%罗哌卡因8份，特耐2份，0.9%生理盐水15份。本发明的优势是：配方中加入非甾体抗炎药（特耐），利用其抗炎作用减少神经水肿，并利用其镇痛作用加强神经阻滞效果。

Description

一种加强型神经阻滞药物组合物
技术领域
本发明涉及医用药物组合物，特别涉及一种加强型神经阻滞药物组合物。
背景技术
在神经干、丛、节的周围注射局麻药，阻滞其冲动传导，使所支配的区域产生麻醉作用，称神经阻滞。神经阻滞只需注射一处，即可获得较大的麻醉区域。但有引起严重并发症的可能，故操作时必须熟悉局部解剖，了解穿刺针所要经过的组织，以及附近的血管、脏器和体腔等。常用神经阻滞有助间、眶下、坐骨、指(趾)神经干阻滞，颈丛、臂神经丛阻滞，以及诊疗用的星状神经节和腰交感神经节阻滞等。
神经阻滞麻醉是临床麻醉尤其是基层医院最常用的麻醉方式，其药物配方大多使用单纯局麻药，如利多卡因，布比卡因，罗哌卡因等，临床使用最广泛的配方是0.75%罗哌卡因10ml，0.9%生理盐水15ml，高浓度局麻药有引起中毒反应风险。
发明内容
针对现有技术中存在的缺陷，本发明的目的在于提供一种加强型神经阻滞药物组合物。
本发明的技术方案如下：
一种加强型神经阻滞药物组合物，由以下体积分数的组分组成：
0.75%罗哌卡因8份，特耐2份，0.9%生理盐水15份。
本发明的优势是：配方中加入非甾体抗炎药（特耐），利用其抗炎作用减少神经水肿，并利用其镇痛作用加强神经阻滞效果。
具体实施方式
实施例1
一种加强型神经阻滞药物组合物，由以下体积分数的组分组成：
0.75%罗哌卡因8ml，特耐2ml，0.9%生理盐水15ml。
实验例
中年男性45岁，体重75kg，既往体健，体格检查：bp139/80mmhg，P70次/分，SPO2100%，R18次/分，各项辅助检查均在正常范围之内。因左尺桡骨骨折，拟在臂丛神经阻滞麻醉下行左尺桡骨骨折切开复位内固定术。采用本发明实施例1制备的药物，行左臂丛神经阻滞，麻醉阻滞效果优，可以满足手术要求。
单纯使用罗哌卡因进行神经阻滞的病人术后肢体疼痛可以持续至术后7-10天，而加用特耐阻滞的病人术后肢体疼痛可以减少至3-5天。
生产厂家及批号：
罗哌卡因辰欣药业股份有限公司批号130224633，
特耐辉瑞制药有限公司批号A27TH。

Claims (1)

1.一种加强型神经阻滞药物组合物，其特征在于由以下体积分数的组分组成：
0.75%罗哌卡因8份，特耐2份，0.9%生理盐水15份。
CN201410113735.5A 2014-03-25 2014-03-25 一种加强型神经阻滞药物组合物 Pending CN103933040A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410113735.5A CN103933040A (zh) 2014-03-25 2014-03-25 一种加强型神经阻滞药物组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410113735.5A CN103933040A (zh) 2014-03-25 2014-03-25 一种加强型神经阻滞药物组合物

Publications (1)

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CN103933040A true CN103933040A (zh) 2014-07-23

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CN201410113735.5A Pending CN103933040A (zh) 2014-03-25 2014-03-25 一种加强型神经阻滞药物组合物

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CN (1) CN103933040A (zh)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103142458A (zh) * 2013-01-22 2013-06-12 莱普德制药有限公司 无成瘾性镇痛缓释递药系统的组方与制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103142458A (zh) * 2013-01-22 2013-06-12 莱普德制药有限公司 无成瘾性镇痛缓释递药系统的组方与制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘付丽等: "帕瑞昔布联合腹腔内罗哌卡因用于腹腔镜胆囊切除术后镇痛", 《肝胆胰外科杂志》 *
陈丽萍: "帕瑞昔布钠复合罗哌卡因用于硬膜外镇痛的临床护理", 《中国医药指南》 *

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Application publication date: 20140723